Field deployable crispr-cas diagnostics and methods of use thereof

ABSTRACT

Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of U.S. Provisional Application Nos. 62/975,743 filed Feb. 12, 2020, 62/993,494 filed Mar. 23, 2020, 63/018,487 filed Apr. 30, 2020, 63/019,406 filed May 3, 2020, 63/032,470 filed May 29, 2020, 63/044,218 filed Jun. 25, 2020, 63/051,248 filed Jul. 13, 2020, and 63/075,684 filed Sep. 8, 2020. The entire contents of the above-identified applications are hereby fully incorporated herein by reference.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH

This invention was made with government support under grant nos. HL141201 and MH110049 awarded by National Institutes of Health. The government has certain rights in the invention.

REFERENCE TO AN ELECTRONIC SEQUENCE LISTING

The contents of the electronic sequence listing (“BROD-5090WP_ST25.txt”; Size is 13,564,627 bytes and it was created on Feb. 10, 2021) is herein incorporated by reference in its entirety.

TECHNICAL FIELD

The subject matter disclosed herein is generally directed to rapid single-reaction coronavirus diagnostics including the use of CRISPR effector systems and thermostable CRISPR Cas proteins.

BACKGROUND

Nucleic acids are a universal signature of biological information. The ability to rapidly detect nucleic acids with high sensitivity and single-base specificity on a portable platform has the potential to revolutionize diagnosis and monitoring for many diseases, provide valuable epidemiological information, and serve as a generalizable scientific tool. Although many methods have been developed for detecting nucleic acids (Du et al., 2017; Green et al., 2014; Kumar et al., 2014; Pardee et al., 2014; Pardee et al., 2016; Urdea et al., 2006), they inevitably suffer from trade-offs among sensitivity, specificity, simplicity, and speed.

Sensitive and rapid detection of nucleic acids is important for clinical diagnostics and biotechnological applications. Particularly when responding to outbreaks, such as the novel coronavirus, which has been referred to as 2019-nCoV and SARS-CoV-2, which causes COVID 2019, time is of the essence. Sabeti, Early Detection Is Key to Combating the Spread of Coronavirus, Time (Feb. 6, 2020). The 2019-nCoV has killed hundreds in a 2-month time span, and response to the escalating outbreak, particularly where there are indications that both symptomatic and asymptomatic patients with 2019-nCov may transmit the disease. Wang, et al., A precision medicine approach to managing Wuhan Coronavirus pneumonia, Prec. Clin. Med, doi:10.1093/pcmedi/pbaa002. Current coronavirus testing kits sent to states and other countries do not work properly, according to the U.S. Centers for Disease Control and Prevention. Grady, “Coronavirus Test Kits Sent to States, 30 Countries Are Flawed, C.D.C. Says,” New York Times, Feb. 12, 2020. Moreover the test being used provides results in four hours from initial sample processing to results. cdc.gov/media/releases/2020/p0206-coronavirus-diagnostic-test-kits. Highly accurate test results at better processing speds, particularly that are field-depoloyable would aid in addressing the outbreak. Currently, the novel coronavirus SARS-CoV-2 has resulted in an international public health emergency, spreading to over 180 countries and infecting more than 300,000 individuals. Testing for the presence of the virus is of utmost importance to both reduce the basic reproductive rate of the virus (R0) and inform best clinical practices for affected patients. However, understanding the full extent of the virus outbreak has remained challenging due to bottlenecks in the diagnosis of infection.

Previously, Applicants developed a platform for nucleic acid detection using CRISPR enzymes called SHERLOCK (Specific High Sensitivity Enzymatic Reporter unLOCKing)(Gootenberg, 2018; Gootenberg, 2017), which combines pre-amplification with the RNA-guided RNase CRISPR-Cas13 (Abudayyeh, 2016; East-Seletsky, 2016; Shmakov, 2015; Smargon, 201; Shmakov, 2017) and DNase CRISPR-Cas12 (Zetsche, 2015 599; Chen, 2018) for sensing of nucleic acids via fluorescence or portable lateral flow.

SUMMARY

In certain example embodiments, a single reaction composition for detecting the presence of a target polynucleotide in a sample is provided, comprising: an extraction-free polynucleotide isolation solution; one or more thermostable Cas proteins possessing collateral activity; at least one guide polynucleotide comprising a sequence capable of binding a target polynucleotide and designed to form a complex with the one or more Cas proteins; isothermal amplification reagents; and a detection construct comprising a polynucleotide component, wherein the Cas protein exhibits collateral nuclease activity and cleaves the polynucleotide component of the detection construct once activated by the target sequence.

The compositions may further comprise amplification reagents for amplification of the coronavirus target sequence. In an aspect the amplification reagents are LAMP reagents. In an aspect, the isothermal amplification reagents comprise optimized LAMP primers and amplification reagents. In an aspect, the optimized LAMP primers are selected from SEQ ID NOs. 1-40,499, and 61,983-61,988. In certain embodiments, the guide polynucleotide is selected from SEQ ID NOs: 40,500-61,643 and SEQ ID NO: 61,989. In an aspect, the guide polynucleotides are optimized guide polynucleotides.

In certain embodiments, the guide polynucleotide comprises a spacer specific for the N gene or S gene of SARS-CoV-2. The compositions may further comprise one or more additives to increase reaction specificity or kinetics, and/or polynucleotide binding beads.

In certain example embodiments, compositions for detecting the presence of a target polynucleotide in a sample, comprising isothermal amplification reagents for amplifying the target polynucleotide, and an extraction-free solution for isolating polynucleotides from a cell or virus particle. The isothermal amplification reagents may comprise LAMP reagents comprising F3, B3, FIP, BIP, Loop Forward and Loop Reverse primers. In an aspect, the LAMP reagents may further comprise oligonucleotide strand displacement (OSD) probes.

In certain example embodiments, a system for the detection of coronavirus is provided. A system for detecting the presence of a coronavirus in a sample, comprising: a Cas protein; at least one guide polynucleotides comprising a guide sequence capable of binding a coronoavirus target sequence and designed to form a complex with the Cas protein; and a detection construct comprising a polynucleotide component, wherein the Cas protein exhibits collateral RNase activity and cleaves the polynucleotide component of the detection construct once activate by the target sequence. In embodiments, the coronavirus is SARS-CoV-2. In an aspect, the at least one guide polynucleotide is a highly active guide polynucleotide. The guide polynucleotide of the system can, an embodiment, bind to a coronavirus sequence encoding a polypeptide that is immunostimulatory to a host immune system, and/or binds to at least one target sequence that is a unique coronavirus genomic sequence.

The systems and methods may utilize one or more Cas proteins. In embodiments, the Cas proteins are a Type V or Type VI Cas protein, and may be Cas 12 proteins, Cas13 proteins, or a combination thereof. In an aspect, the one or more Cas proteins comprise a thermostable protein. In example embodiment the Cas protein is a Cas13, which may be a thermostable Cas13 or Leptotrichia wadei Cas13. In an aspect, the one or more Cas proteins comprise a Cas12, which may be a thermostable Cas12b, for example Alicyclobacilluys acidiphilus Cas12b or Brevibacillus sp. SYSU G02855 (Br) Cas12b. In an aspect, the guide polynucleotide comprises a guide derived from Alicyclobacillus acidoterrestris. In an aspect, the Alicyclobacillus acidoterrestris sequence selected from Aac guide types 1 to 5 (SEQ ID NOs: 62006 to 62010). In an embodiment, the Cas12b protein is Brevibacillus sp. SYSU G02855 and the guide sequence comprises crRNA design 1 to 3 (SEQ ID NO:62003-62005).

The systems may further comprise amplification reagents for amplification of the coronavirus target sequence. In an aspect the amplification reagents are LAMP reagents.

Methods for detecting a target nucleic acid in a sample are also provided, comprising distributing a sample or set of samples into individual discrete volumes, each individual discrete volume comprising a composition as disclosed herein, incubating the sample or set of samples at conditions sufficient to allow lysis of a cell or virus via reagents of the extraction-free polynucleotide isolation solution; amplifying the target polynucleotides using isothermal amplification, wherein isolation of target polynucleotides between the incubating and amplifying steps is not required; an detecting amplified target polynucleotides by binding of the CRISPR-Cas complex to the target polynucleotides, wherein binding of the target polynucleotides activates cleavage of the detection construct thereby generating a detectable signal.

A lateral flow device comprising a substrate comprising a first end and a second end, are also provided, the first end comprising a sample loading portion, a first region comprising a detectable ligand, two or more systems of the claims provided herein, and one or more first capture regions, each comprising a first binding agent; the substrate comprising two or more second capture regions between the first region of the first end and the second end, each second capture region comprising a different binding agent. In an aspect, the first end comprises two detection constructs, wherein each of the two detection constructs comprises an RNA or DNA oligonucleotide, comprising a first molecule on a first end and a second molecule on a second end. In an aspect, the first end comprises three detection constructs, wherein each of the three detection constructs comprises an RNA or DNA oligonucleotide, comprising a first molecule on a first end and a second molecule on a second end. The lateral flow device may comprise a polynucleotide encoding a Cas13 and/or Cas12 and the one or more guide RNAs are provided as a multiplexing polynucleotide, the multiplexing polynucleotide configured to comprise two or more guide sequences.

Methods for detecting a target nucleic acid in a sample are also provided, comprising contacting a sample with the first end of the lateral flow device comprising the sample loading portion, wherein the sample flows from the sample loading portion of the substrate towards the first and second capture regions and generates a detectable signal. Methods may utilize a lateral flow device capable of detecting two different target nucleic acid sequences. In an aspect, the target nucleic acid sequences are absent from the sample, a detectable signal is generated at each capture region, the detectable signal appears at the first and second capture regions. The lateral flow device can be designed such that when the target nucleic acid sequences are absent from the sample, a detectable signal is generated at each capture region, and wherein when the sample contains one or more target nucleic acid sequences, a detectable signal is absent at the capture region for the corresponding target nucleic acid sequence.

Methods for detection may also comprise detecting coronavirus in a sample by contacting the sample with the systems disclosed herein. The step of contacting the sample with the system can comprise amplifying the one or more target sequences in the sample and incubating the sample under conditions sufficient to allow binding of the guide polynucleotides to one or more target molecules; activating the Cas protein via binding of the guide polynucleotides to one or more target sequencess, wherein activating the Cas protein results in modification of the detection construct such that a detectable signal is generated.

The step of contacting the sample with the system can further comprise incubating the sample at about 55° C. to about 65° C., about 59° C. to 61° C. or about 60° C. for 50 to 70 minutes and detecting the presence of a positive signal. The steps of extracting, amplifying incubating, activating and detecting are all performed in the same individual discrete volume.

Methods of detection can further comprise the step of treating the sample with a DNA extraction solution prior to contacting the sample with the systems disclosed herein.

In an aspect, the DNA extraction solution is mixed with a sample at a concetration of about 1:2 to 2:1 sample:extraction solution. In an aspect, the method may further comprise incubating the sample and the DNA extraction solution, which may be performed at a temperature of about 20° C. to 60° C. for about 60 minutes, or 95° C. for about 5 to 10 minutes. Extraction may also comprise the addition of beads capable of concentrating targets of interest of the sample, in an aspect, the beads are magnetic.

A cartridge for detection assays in accordance with methods disclosed herein is provided comprising a sample receiver, at least a first, second, and third ampoule, and at least a first and second chamber, and a lateral flow strip, wherein the first ampoule is communicatively coupled to the first chamber comprising a heat source, the first chamber is communicatively coupled to the second ampoule, the second ampoule communicatively coupled to the second chamber, the third ampoule communicatively coupled to the lateral flow strip.

A cartridge can be provided comprising at least a first and second ampoule, a lysis chamber, an amplification chamber and a sample receiving chamber, the first ampoule fluidically connected to the sample receiving chamber, the sample receiving chamber further connected to the lysis chamber, the lysis chamber connected via a metering channel to the second ampoule and the amplification chamber. In certain embodiments, the first ampoule comprises an extraction-free polynucleotide isolation solution and the second ampoule comprise isothermal amplification reagents amplifying a target polynucleotide or isothermal amplification reagents and a CRISPR-Cas collateral detection system for amplifying and detecting a target polynucleotide. In an aspect, wherein the extraction-fee polynucleotide isolation solution and/or the lysis well comprises polynucleotide binding bead.

The cartridge may be configured to fit in a system comprising a heating means, an optic means, a means for releasing reagents on the cartridge, and a means for readout of assay result. The cartridge can comprise a first ampoule that comprises lysis buffer, and/or the second ampoule that comprises a CRISPR system, the CRISPR-Cas system comprising one or more Cas proteins and at least one guide polynucleotide.

The cartridge may further comprise amplification reagents. The amplification reagents comprise LAMP F3, B3, FIP, BIP, Loop Forward and Loop Reverse primers.

The cartridge can comprise a CRISPR system that includes a guide RNA designed to bind to a target nucleic acid that are diagnostic for a disease state. The disease state can be an infection, which may be caused by a microbe, the microbe selected from a virus, bacterium, a fungus, a protozoa, or a parasite. The guide RNA may be specific for a microbe that is viral, bacterial, or fungal.

The cartridge can further comprise a detection construct comprising a polynucleotide component, which may be fluorescent. In an aspect, the cartridge comprises a CRISPR system that is lyophilized. In an aspect, the Cas protein of the CRISPR system is a Type V or Type VI Cas protein. In an aspect, the Cas protein is a Cas12 or Cas13 protein. The cartridge cancomprise a thermostable protein, for example, the thermostable Cas protein is Alicyclobacillus acidiphilus Cas12b (Aap). In an aspect, the guide comprises a sequence derived from Alicyclobacillus acidoterrestris (Aac). The cartridge can comprise a lysis buffer that comprises a DNA extraction buffer.

A device designed to receive the one or more cartridges as disclosed herein is provided, which may further comprise a one or more motors connected to a plunger for rupturing of the first and second ampoule of the cartridge and configured within the device to align with the first and second ampule of the inserted cartridge, a heating element configured to align with the amplification chamber of the inserted cartridge, an optical detector configured to align with the amplification chamber of the inserted cartridge, and a display. The device may comprise a graphical user interface for programming the device and/or readout of the results of the assay. A system comprising a docking station and two or more devices as disclosed herein is provided, wherein the docking station is configured to receive the two or more devices.

A system designed to receive the detection cartridge as disclosed herein is provided, the system designed to receive the cartridge and conduct an assay comprising isothermal amplification of nucleic acids and detection of target nucleic acids on the cartridge. In embodiments, the system can comprise one or more heating means for extraction, amplification and/or detection, a means for releasing reagents for extraction, amplification, and/or detection, a means for mixing reagents for extraction, amplification, and/or detection, and/or a means for reading the results of the assay. In an aspect, the means of reading the results of the assay is an optic means. The system can further comprise a user interface for programming the device and/or readout of the results of the assay.

These and other aspects, objects, features, and advantages of the example embodiments will become apparent to those having ordinary skill in the art upon consideration of the following detailed description of illustrated example embodiments.

BRIEF DESCRIPTION OF THE DRAWINGS

An understanding of the features and advantages of the present invention will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the invention may be utilized, and the accompanying drawings of which:

FIG. 1 —includes lateral flow assay detection for three n2019-CoV targets, left, middle and right groups. Testing for each target shown with decreasing concentrations from left to right, with far right at 0 concentration S protein (left), middle, synthetic S (synthego) and right (Orflab).

FIG. 2A-2B— (A) Detection of synthetic COVID-19 sequences using a two-step SHERLOCK reaction (25 min RPA), in accordance with certain example embodiments. (B) Detection of synthetic COVID-19 sequence using a two-step example embodiment reaction (25 min RPA followed by 30 min Cas13 reaction) with lateral flow strip readout, in accordance with certain example embodiments.

FIG. 3A-3B.— (A) Quick Extract at a final concentration of 5% did not negatively affect the RT-qPCR reaction. (B) RNA samples prepared using Quick Extract according to exemplary embodiment supported similarly sensitive detection of coronavirus as QIAmp Viral RNA Miniprep.

FIG. 4 —Schematic for developing a one pot RT-LAMP Cas12b SHERLOCK reaction, in accordance with certain example embodiments.

FIG. 5 —provides results obtained for assessing limit of detection by lateral flow assay at 60° C. for 60 minutes, in accordance with certain example embodiments. The limit of detection was 100 molecules per reaction.

FIG. 6 — Graph shows quantification of lateral flow assay from FIG. 5 . The bar graph represents quantification of top band intensity/bottom band intensity.

FIG. 7 — Shows that certain example embodiments can reliably perform at 2× the limit of detection.

FIG. 8 — Graph showing that certain example embodiments can reliably perform at 2× the limit of detection. The graph represents quantification of top band intensity/bottom band intensity of lateral flow assays from FIG. 7 .

FIG. 9 — Shows that certain example embodiments of the assay have no cross-reactivity with SARS-CoV or MERS-CoV.

FIG. 10 — Shows that a 50 minute incubation is sufficient to reach reaction saturation at 2× limit of detection, in accordance with certain example embodiments.

FIG. 11 — Shows that an example embodiment is robust across a 10° C. window.

FIG. 12 — Shows that an example embodiment can be master mixed and freeze-thawed for six freeze-thaw cycles or more.

FIG. 13 — Shows positive detection of COVID in 12 patients, in accordance with certain example embodiments.

FIG. 14 — The certain example embodiments of the assay can be run for less than $40 using conventional heating devices such as a sous vide heater

FIG. 15 — Shows results obtained using an example embodiment of the assay on 9 different patients using a nasopharyngeal swab sample. The results were compared to qPCR tests.

FIG. 16 — A schematic of an example embodiment of the diagnostic assay.

FIG. 17 — Shows the different additives that may be used to optimize assay sensitivities and/or kinetics, in accordance with certain example embodiments.

FIG. 18 — Shows that a limit of detection of 100 molecules per reaction is reached with certain example embodiments.

FIG. 19 — Shows a comparison of positive tests to results obtained from qRT-PCR assays.

FIG. 20 — Illustrates a low cost assay setup using a sous vide cooker, in accordance with certain example embodiments.

FIG. 21 — Shows a point-of-care device that is compatible with certain example embodiments.

FIG. 22 — Demonstrates that LAMP primers, in accordance with certain example embodiments, are active at lower temperatures.

FIG. 23 — Demonstrates an example embodiment combining Alicyclobacillus acidoterrestris Cas12b (AacCas12b) with LAMP at 55° C. enables one-pot COVID-19 detection. Input comprised RNA genome of COVID-19 broken into 5 kb fragments.

FIG. 24 — Demonstrates an example embodiment using multiple primer-sets and guide combinations targeting different COVID-19 genes. 200 aM detection limit was achieve by 150 minutes. Input comprised RNA genome of COVID-19 broken into 5 kb fragments.

FIG. 25A-25F— Development of a point-of-care (POC) example embodiment using RT-LAMP and thermophilic AapCas12b. (25A) Comparison of the example POC embodiment N gene LAMP primer set to two established LAMP primer sets measured by real-time fluorescence at varying levels of SARS-CoV-2 standard genomes. (25B) Temperature comparison of AapCas12b collateral activity activated by RT-LAMP amplified inputs, including 20 fM SARS-CoV-2 standards and NTC controls. (25C) AapCas12b collateral activity when incubated with AapCas12b or AacCas12b crRNAs and RT-LAMP amplified 20 fM SARS-CoV-2 standards or NTC. (25D) AapCas12b collateral activity measured using different guides for RT-LAMP amplified 20 fM SARS-CoV-2 standards or NTC. (25E) Example POC embodiment (One-pot Cas12b and RT-LAMP) results when using AapCas12b or AacCas12b and varying amounts of SARS-CoV-2 inputs or NTC. (25F) Example POC embodiment real-time fluorescence performance measured with glycine or taurine additives at 2 fM SARS-CoV-2 input or NTC.

FIG. 26A-26D— provides performance metrics of an example embodiment on lateral flow strips. (26A) Effect of reaction temperature on example POC embodiment lateral flow detection for 200 SARS-CoV-2 copies per reaction and NTC. (26B) Effect of reaction incubation time on exemplary embodiment lateral flow detection for 100 SARS-CoV-2 copies per reaction and NTC. (26C) Effect of master mix freeze-thaw cycles on example POC embodiment lateral flow detection for 200 SARS-CoV-2 copies per reaction and NTC. (26D) Measurement of cross-reactivity for COVID-19 example POC embodiment lateral flow test for SARS and MERS N genes compared to NTC. All inputs were at 1,000 copies per reaction.

FIG. 27 —provides COVID-19 detection results for patient samples tested in FIG. 19 according to an exemplary POC embodiment. The results yield a sensitivity of 97% and specificity of 100%.

FIG. 28A-28B— COVID-19 example POC embodiment detection with SARS-CoV-2 positive patient nasopharyngeal swabs. (28A) COVID-19 detection of 12 different SARS-CoV-2 positive patient nasopharyngeal swabs with three replicates for each sample according to example POC embodiment. Prior to the exemplary embodiment assay, nasopharyngeal swabs were lysed using QE for 5 minutes at 22° C. Listed below are Ct values determined by RT-PCR using the CDC N1 and N2 assays. (28B) Example POC embodiment COVID-19 detection of 12 different SARS-CoV-2 positive patient nasopharyngeal swabs with three replicates for each sample. Prior to conducting assay according to example POC embodiment, nasopharyngeal swabs were lysed using QE for 5 minutes at 60° C. Listed below are Ct values determined by RT-PCR using the CDC N1 and N2 assays.

FIG. 29 —Comparison of different lysis temperatures for SARS-CoV-2 positive patient nasopharyngeal swab extraction as measured by Ct values from RT-PCR using the CDC N1 and N2 assays. For patients 9 and 10, due to the low volume of samples provided, samples tested with 22° C. and 60° C. lysis conditions were diluted 1:2 prior to example POC embodiment assay and RT-qPCR.

FIG. 30A-30B—shows the top view (30A) and side view (30B) of an exemplary cartridge (10) according to the invention.

FIG. 31A-31C—device according to an exemplary embodiment. (31A) provides an exemplary front loading device, upper left shows a friction hinged door with magnetic latch to prevent unwanted objects and dirt from entering the cartridge slot, upper right, device showing use of LED lights to display operating states, positive and negative results; lower image depicts rear of device with USB-C port located in a recess; (31B) shows three views of a quad-dock for a front loading device, showing USB port located at the back of each cavity; (31C) shows stacking docs for 8 devices, on the left, a side profile, center front view, and rights, low profile feet on the botto of the dock.

FIG. 32 —shows alternate front-loading device with screen, left with front hinge open; right, with front hinge closed with alternate screen and simple user interface with running, positive, negative results r other display information

FIG. 33 —depicts front loading internal details, tope view (left) shows geared otor, optics and USB-C port; profile view (right) shows cartridge detection sensor, cam wheel, main PCBA, heater and plunger.

FIG. 34A-34C— depicts exemplary embodiments of the device. (34A) shows top loading device detains, friction hinged lid with magnetic latch to access cartridge slot (upper left), USB-C port in recess on the bottom of each device (lower left), front view of a top loading details (right) shows status display LED strip; (34B) top loading device quad-dock, USB port located in each cavity (left), quad dock with four top loading devices in closed lid orientation (upper right), quad dock with four top loading devices with one device in open lid orientation (lower right); (34C) top loading device octo-dock, rear view showing single rear power inlet (upper left), All 8 devices in octo-dock in open orientation (upper right), USB-C port located in each device cavity (lower left), and status display LED strip on octo dock with 8 devices in closed orientation (lower right).

FIG. 35A-35B—Expanded patient cohort testing from an example embodiment showing results of patient nasopharyngeal swab samples (35A) with calculated predictive values, sensitivity and specificity (35B)

FIG. 36 —Concentration with magnetic beads according to an example embodiment. Upper panel shows old workflow, lower panel with homebrew beads

FIG. 37A-37C—Simplifying bead purification for POC application shows no mixing is required after addition of Master Mix according to certain exemplary embodiments Free Beads (37A), beads on magnet (Elution only)(37B), beads on magnet (binding and elution)(37C).

FIG. 38A-38B—Simplifying Bead purification for POC application shows removing the wash step requires significant reduction in salt concentration in the reaction buffer. (38A) NaCl beads; (38B) KCl beads.

FIG. 39 — An example workflow demonstrating increased sensitivity while minimizing complexity.

FIG. 40 — Shows data from an example embodiment demonstrating limit of detection (LOD) of 100 genomes per reaction from saliva or nasopharyngeal swabs

FIG. 41 — Shows results of 12 replicates (right) using sous-vide waterbath (left) for reaction conducted according to certain example embodiments.

FIG. 42A-42B— Shows data from an example embodiment demonstrating an ability to achieve 97% sensitivity and 100% specificity on patient nasopharyngeal swab samples

FIG. 43 — Shows CRISPR detection may improve upon LAMP by increased specificity.

FIG. 44 — Provides data showing an ability to detect target in 20 to 30 minutes in accordance with certain example embodiments.

FIG. 45 — Shows secondary structure of guide of Alicyclobacillus acidoterrestris (Aac) that is used with Alicyclobacillus acidiphilus (Aap) Cas12b in exemplary CRISPR Systems.

FIG. 46 —shows BrCas12b is active with mature crRNA and described tracrRNA 1-3, detailed herein and in accordance with certain example embodiments.

FIG. 47 —shows BrCas12b works well in the 60-70° C. temperature range in accordance with certain example embodiments.

FIG. 48 —shows BrCas12b is more stable than AapCas12b at 60° C. when used in accordance with certain example embodiments.

FIG. 49 —shows BrCas12b can achieve rapid detection is less than 20 minutes down to 200 aM for multiple LAMP primer sets in accordance with certain example embodiments.

FIG. 50 —shows WCV329 reporter choice with BrCas12b.

FIG. 51 —shows exemplary use of oligonucleotide strand displacement (OSD) probe and LAMP amplification at 21 minutes, with varied copies per reaction

FIG. 52 —shows optimization of OSD probe concentration for COVID detection with LAMP reagents in accordance with certain example embodiments.

FIG. 53A-53C—workflow and performance evaluation in accordance with certain example embodiments. A nasopharyngeal (NP) or anterior nasal swab is dipped in 400 extraction buffer containing lysis buffer and magnetic beads. After 10 mins at room temperature, the sample is placed on a magnet and extraction buffer is aspirated. 50 μL of an exemplary embodiments reaction is added to the beads, and the sample is heated to 60° C. For lateral flow readout, after 80 mins, detection strips are dipped into the reaction. For fluorescence readout, after 45 mins, the reaction can be interpreted using a fluorescence reader. (53B) Results for assay conducted in accordance with certain example embodiment of 202 SARS-CoV-2 positive manufactured patient NP swab samples detected by fluorescence readout. A swab with 50 μL of viral transport medium was dipped into the extraction buffer. Ct values were determined using standard RT-qPCR workflows. Red dashed line indicates threshold for classifying samples. Endpoint fluorescence at 45 mins are shown. (53C) Same as (53B), for 200 SARS-CoV-2 negative manufactured patient NP swab samples. Samples are sorted by endpoint fluorescence.

FIG. 54A-54E—provides exemplary sample extraction using DNA QuickExtract and top LAMP primer sets targeting SARS-CoV-2. (54A) Effects of different lysis buffers on RT-qPCR. Different amounts of SARS-CoV-2 genomic standards were spiked into lysis buffers and used as input for the CDC N1 RT-qPCR assay. (54B) Comparison of lysis buffers for extracting lentiviral RNA measured by RT-qPCR targeting the RFP RNA. (54C) Comparison of lysis buffers to the standard QIAmp Viral RNA Miniprep extraction on SARS-CoV-2 RNA positive patient nasopharyngeal (NP) swab viral transport media (VTM). The 0.1% SDS condition did not produce any detectable Ct values. ND, not detected. (54D) Schematic of reverse transcription followed by Loop-mediated Isothermal Amplification (RT-LAMP) and CRISPR-mediated detection. Viral RNA is reverse transcribed and amplified using RT-LAMP. Cas12b detection of the LAMP product triggers collateral cleavage of a reporter to produce signal for detection. (54E) Comparison of LAMP primer sets targeting different regions of the SARS-CoV-2 genome to two established LAMP primer sets measured by real-time fluorescence across a range of concentrations of SARS-CoV-2 RNA amplicons at 65° C. NTC, no template control.

FIG. 55A-55E—Optimization of Aap sgRNAs targeting SARS-CoV-2 LAMP amplicons for one-pot reactions. (55A) Temperature dependence of AapCas12b collateral activity when incubated with RT-LAMP amplified SARS-CoV-2 genomic standards. Collateral activity was measured as end point fluorescence after incubation. (55B) Comparison of AapCas12b collateral activity with either a previously published AmCas12b sgRNA scaffold or an AacCas12b-based scaffold when incubated with RT-LAMP amplified SARS-CoV-2 genomic standards. (55C) Comparison of 3′ end of Aap and Aac Cas12b sgRNA scaffolds. Color indicates base-pairing probability determined by RNAfold. (55D) Collateral activity of AapCas12b using different guides (Table 16) when incubated with RT-LAMP amplified SARS-CoV-2 genomic standards or no template control, NTC. Assay was performed at 60° C. and collateral activity was measured by fluorescence after 5 and 15 mins. (55E) Comparison of the best Cas12b sgRNA targeting each of the 4 top LAMP sets at different Magnesium concentrations in the reaction. Different amounts of SARS-CoV-2 genomic standards spiked into NP swab were used as input. NTC, no template control.

FIG. 56A-56B—Optimization of exemplary embodiment with additive reagents. (56A) Titration of Glycine and Taurine additive concentrations for effects on performance of detection according to a certain exemplary embodiment assay of varying amounts of SARS-CoV-2 genomic standards spiked into NP swab. (56B) Comparison of fluorescence signal generated by LAMP alone (left), LAMP in an exemplary embodiment (middle), and AapCas12b in exemplary embodiment (right) for varying amounts of SARS-CoV-2 genomic standards. LAMP signal was measured using SYTO9 nucleic acid stain and AapCas12b signal was measured using collateral cleavage of a HEX reporter. NTC, no template control.

FIG. 57A-57B—Performance of exemplary embodiment with lateral flow readout. (57A) Determination of the sensitivity for exemplary embodiment with lateral flow readout at 60 minutes using three replicates per condition. Different amounts of SARS-CoV-2 genomic standards spiked into saliva (top) or nasopharyngeal (NP) swab (middle) were lysed by adding an equal volume of DNA QuickExtract and heating for 5 mins at 95° C. At 200 genome copies per reaction in NP swab, the example embodiment yielded positive results for all 30 replicates (bottom). (57B) Quantitation of the band intensity ratio (top band/bottom band) for the NP swab sensitivity (left) and reproducibility (right) from 56A panel. ***, P<0.001. Red dashed line indicates threshold for classification.

FIG. 58 —Multiplexing internal control LAMP primer sets in an exemplary embodiment. Comparison of LAMP primer sets targeting ACTB and GAPDH genes to control for sample extraction and isothermal amplification on different amounts of SARS-CoV-2 genomic standards spiked into saliva or water control. Control primer sets were mixed with an exemplary embodiment LAMP primer set targeting the N gene at 50% or 20% of the total primer concentration. LAMP signal was detected using the SYTO9 nucleic acid stain and Cas12b signal was detected via collateral cleavage of a HEX reporter probe. Values indicate time to reach the half maximum fluorescence for each reaction.

FIG. 59A-59H— Performance of exemplary multiplexed embodiment fluorescence readout. LAMP primer sets targeting ACTB or the SARS-CoV-2 gene N were pooled at 20% and 80% of the total primer concentration respectively. LAMP signal was detected using the SYTO9 nucleic acid stain and Cas12b signal was detected via collateral cleavage of a HEX reporter probe. Endpoint normalized fluorescence signal was determined at 28 mins for LAMP and at 45 mins for Cas12b. (59A) Determination of the sensitivity for exemplary multiplexed embodiment with fluorescence readout using three replicates per condition. Different amounts of SARS-CoV-2 genomic standards spiked into nasopharyngeal (NP) swab was used for input. Values represent endpoint normalized fluorescence. (59B) Same as (59A) with values indicating time to reach the half maximum fluorescence. (59C) Determination of sensitivity for exemplary multiplexed embodiment using SARS-CoV-2 genomic standards spiked into saliva as input. Values represent endpoint fluorescence signals. (59D) Same as (59C) with values indicating time to reach the half maximum fluorescence. (59E) Reliability assessment of exemplary multiplexed embodiment using 30 replicates at 300 copies and 200 copies of SARS-CoV-2 genomic standards spiked into NP swab. (59F) Same as (59E) with values indicating time to reach the half maximum fluorescence. (59G) Effect of reaction temperature on exemplary multiplexed embodiment detection for 300 SARS-CoV-2 copies spiked into NP swab per reaction. Data represents three replicates per condition. (59H) Same as (59G) with values indicating time to reach the half maximum fluorescence.

FIG. 60A-60D—Evaluation of exemplary embodiment on SARS-CoV-2 patient nasopharyngeal swab samples. (60A) Quantification of the band intensity ratios of lateral flow results from panel (FIG. 35A). Red dashed line indicates threshold for classification. (60B) Table summarizing the example embodiment results on patient NP swab samples tested at Broad Institute. Results according to the example embodiment were considered positive if 2 out of 3 replicates were positive. (60C) Table summarizing example embodiment results on patient NP swab samples tested at the University of Washington Virology lab. (60D) Determination of the limit of detection using 5-fold serial dilutions of SARS-CoV-2 positive patient NP swab samples. Ct values represent the average of ORF lab and E gene assays from the Cobas 6800 RT-qPCR assay.

FIG. 61A-61D—Lysis temperature optimization and Ct distribution of SARS-CoV-2 patient nasopharyngeal swab samples according to certain exemplary embodiments. (61A) Results for 21 unique SARS-CoV-2 positive and 10 negative patient nasopharyngeal (NP) swab samples in triplicate detected by exemplary embodiment lateral flow readout. Prior to conducting exemplary embodiment, NP swab viral transport media (VTM) was lysed by adding an equal volume of DNA QuickExtract and heating for 10 mins at 60° C. (61B) Same as (61A) lysed for 10 mins at 22° C. (61C), Comparison of Ct values for the same set of samples lysed at 95° C., 60° C. and 22° C. from panels (61A) and (61B) and FIG. 35A. For patients 9 and 10, due to the low volume of samples available, samples lysed at 60° C. and 22° C. were diluted 1:2 prior to evaluation according to example embodiment and RT-qPCR. (61D) Scatterplot of 2,105 SARS-CoV-2 positive patient Ct values from the University of Washington Virology lab. Patient NP swab samples were tested using the cobas SARS-CoV-2 assay. The averages of ORF lab and E-gene Ct values are shown. For samples with undetected ORF lab or E-gene results, only the Ct value of the detected assay is shown.

FIG. 62A-62E—Optimization of an example embodiment by concentration sample input using magnetic bead concentration. (62A) Comparison of laboratory-developed and commercial (Beckman SPRIselect) magnetic bead formulations for sample concentration prior to conducting an example embodiment assay. Samples were eluted in water, an exemplary embodiment mastermix (MM), or exemplary embodiment mastermix retaining the magnetic beads. Values represent endpoint fluorescence signal at 45 mins. (62B) Determination of the sensitivity for purification with and without beads using fluorescence readout. Different amounts of SARS-CoV-2 genomic standards spiked into 200 μL of DNA QuickExtract with 1.25 μg of human RNA were used as the starting sample for both methods. (62C) Titration of different magnetic bead buffer components in exemplary embodiment reactions using 1,000 SARS-CoV-2 genomic standards spiked into 200 μL of DNA QuickExtract with 1.25 μg of human RNA. Fluorescence traces represent data from two biological replicates. (62D) Comparison of magnetic beads with either 1M NaCl (top) or KCl (bottom) in the buffer for sample concentration without ethanol wash prior to example embodiment assay. Exemplary embodiment reactions contained varying concentrations of KCl. Different amounts of SARS-CoV-2 genomic standards spiked into 200 μL of DNA QuickExtract with 1.25 μg of human RNA were used as the starting sample. (62E) Comparison of different lysis approaches according to an exemplary embodiment: buffer, amount of buffer, and temperature, either as a separate step or combined with magnetic bead binding. Mock SARS-CoV-2 virus (SARS-CoV-2 RNA targets in a noninfectious viral coat) were used to assess lysis efficacy. NTC, no template control. ND, not detected.

FIG. 63A-63E—Optimization of exemplary embodiment and limit of detection assessment. (63A) Titration of AapCas12b and sgRNA concentrations for effects on performance of exemplary embodiment. 500 copies of SARS-CoV-2 genomic standards were directly added to exemplary embodiment reactions without magnetic bead concentration. Two biological replicates were used for 500 copies and for 62 biological replicates were used for NTC (no template control) to evaluate sensitivity and specificity. Values represent endpoint fluorescence at 45 mins. (63B) Confirmation that lowering the AapCas12b and sgRNA concentrations to 31.3 nM does not affect the sensitivity of the exemplary embodiment. Different amounts of mock SARS-CoV-2 virus (SARS-CoV-2 RNA targets in a noninfectious viral coat) were added to extraction buffer containing lysis buffer and magnetic beads. Three biological replicates were used for 100, 250, or 500 copies and 87 biological replicates were used for 0 copies to evaluate sensitivity and specificity. Values represent endpoint fluorescence at 45 mins. (63C) Comparison of the limit of detection (LOD) for the standard CDC workflow (top) to an exemplary embodiment (middle and bottom). SARS-CoV-2 virus-like particles (SARS-CoV-2 RNA targets in a noninfectious viral coat) and 1.25 μg of human RNA were added to VTM or extraction buffer containing lysis buffer and magnetic beads. Exemplary embodiment fluorescence readout (middle) was evaluated using time for the fluorescence signal to reach the classification threshold (Example 10 Methods). Exemplary embodiment lateral flow readout (bottom) was quantified and interpreted using a mobile phone application with the red dashed line indicating the threshold for classification. ND, not detected. (63D), Dilution series using two SARS-CoV-2 RNA positive patient nasopharyngeal (NP) swab viral transport medium (VTM) to estimate sensitivity of the exemplary embodiment. A swab was used to transfer 50 μL of the sample into the extraction buffer. Ct values represent projected values for each 5-fold dilution in VTM. NTC, no template control. (63E) Estimation of sensitivity of exemplary embodiment by averaging the highest Ct values that were positive in all 3 replicates for each patient.

FIG. 64A-64E—Performance evaluation of exemplary embodiment using SARS-CoV-2 patient samples. (64A) exemplary embodiment results for 202 SARS-CoV-2 positive patient nasopharyngeal (NP) swab viral transport medium (VTM) samples detected by fluorescence readout. A swab with 50 μL of the sample was dipped into the extraction buffer. Ct values were determined using standard RT-qPCR workflows. Time to reach the fluorescence threshold in an example embodiment for 188 positive samples is shown. (64B-64C) exemplary embodiment results for SARS-CoV-2 negative patient anterior nasal (AN) swabs. Dry AN swabs with mock SARS-CoV-2 virus were dipped in extraction buffer. Data represents endpoint fluorescence (64B) or time to fluorescence threshold (64C). (64D-64E) exemplary embodiment results for 5 SARS-CoV-2 positive patient dry AN swabs. Data represents endpoint fluorescence (64D) or time to fluorescence threshold (64E). Ct values represent respective NP swab RT-qPCR results.

FIG. 65A-65B— Exemplary mobile phone application and equipment required for an example embodiment. (65A) Wireframe of mobile phone application for interpreting an exemplary embodiment lateral flow readout. Application starts with an exemplary embodiment workflow followed by camera capture of a lateral flow strip image and result interpretation. (65B) Equipment and consumables needed for running exemplary methods of detection according to an example embodiment.

The figures herein are for illustrative purposes only and are not necessarily drawn to scale.

DETAILED DESCRIPTION OF THE EXAMPLE EMBODIMENTS General Definitions

Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure pertains. Definitions of common terms and techniques in molecular biology may be found in Molecular Cloning: A Laboratory Manual, 2^(nd) edition (1989) (Sambrook, Fritsch, and Maniatis); Molecular Cloning: A Laboratory Manual, 4^(th) edition (2012) (Green and Sambrook); Current Protocols in Molecular Biology (1987) (F. M. Ausubel et al. eds.); the series Methods in Enzymology (Academic Press, Inc.): PCR 2: A Practical Approach (1995) (M. J. MacPherson, B. D. Hames, and G. R. Taylor eds.): Antibodies, A Laboratory Manual (1988) (Harlow and Lane, eds.): Antibodies A Laboraotry Manual, 2nd edition 2013 (E. A. Greenfield ed.); Animal Cell Culture (1987) (R. I. Freshney, ed.); Benjamin Lewin, Genes IX, published by Jones and Bartlet, 2008 (ISBN 0763752223); Kendrew et al. (eds.), The Encyclopedia of Molecular Biology, published by Blackwell Science Ltd., 1994 (ISBN 0632021829); Robert A. Meyers (ed.), Molecular Biology and Biotechnology: a Comprehensive Desk Reference, published by VCH Publishers, Inc., 1995 (ISBN 9780471185710); Singleton et al., Dictionary of Microbiology and Molecular Biology 2nd ed., J. Wiley & Sons (New York, N.Y. 1994), March, Advanced Organic Chemistry Reactions, Mechanisms and Structure 4th ed., John Wiley & Sons (New York, N.Y. 1992); and Marten H. Hofker and Jan van Deursen, Transgenic Mouse Methods and Protocols, 2nd edition (2011).

As used herein, the singular forms “a”, “an”, and “the” include both singular and plural referents unless the context clearly dictates otherwise.

The term “optional” or “optionally” means that the subsequent described event, circumstance or substituent may or may not occur, and that the description includes instances where the event or circumstance occurs and instances where it does not.

The recitation of numerical ranges by endpoints includes all numbers and fractions subsumed within the respective ranges, as well as the recited endpoints.

The terms “about” or “approximately” as used herein when referring to a measurable value such as a parameter, an amount, a temporal duration, and the like, are meant to encompass variations of and from the specified value, such as variations of +/−10% or less, +/−5% or less, +/−1% or less, and +/−0.1% or less of and from the specified value, insofar such variations are appropriate to perform in the disclosed invention. It is to be understood that the value to which the modifier “about” or “approximately” refers is itself also specifically, and preferably, disclosed.

As used herein, a “biological sample” may contain whole cells and/or live cells and/or cell debris. The biological sample may contain (or be derived from) a “bodily fluid”. The present invention encompasses embodiments wherein the bodily fluid is selected from amniotic fluid, aqueous humour, vitreous humour, bile, blood serum, breast milk, cerebrospinal fluid, cerumen (earwax), chyle, chyme, endolymph, perilymph, exudates, feces, female ejaculate, gastric acid, gastric juice, lymph, mucus (including nasal drainage and phlegm), pericardial fluid, peritoneal fluid, pleural fluid, pus, rheum, saliva, sebum (skin oil), semen, sputum, synovial fluid, sweat, tears, urine, vaginal secretion, vomit and mixtures of one or more thereof. Biological samples include cell cultures, bodily fluids, cell cultures from bodily fluids. Bodily fluids may be obtained from a mammal organism, for example by puncture, or other collecting or sampling procedures.

The terms “subject,” “individual,” and “patient” are used interchangeably herein to refer to a vertebrate, preferably a mammal, more preferably a human. Mammals include, but are not limited to, murines, simians, humans, farm animals, sport animals, and pets. Tissues, cells and their progeny of a biological entity obtained in vivo or cultured in vitro are also encompassed.

Various embodiments are described hereinafter. It should be noted that the specific embodiments are not intended as an exhaustive description or as a limitation to the broader aspects discussed herein. One aspect described in conjunction with a particular embodiment is not necessarily limited to that embodiment and can be practiced with any other embodiment(s). Reference throughout this specification to “one embodiment”, “an embodiment,” “an example embodiment,” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Thus, appearances of the phrases “in one embodiment,” “in an embodiment,” or “an example embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment, but may. Furthermore, the particular features, structures or characteristics may be combined in any suitable manner, as would be apparent to a person skilled in the art from this disclosure, in one or more embodiments. Furthermore, while some embodiments described herein include some but not other features included in other embodiments, combinations of features of different embodiments are meant to be within the scope of the invention. For example, in the appended claims, any of the claimed embodiments can be used in any combination.

Reference is made to U.S. patent application Ser. No. 16/894,678 entitled Novel Type V CRISPR-Cas Systems and Use Thereof filed Jun. 5, 2020, Ser. No. 16/894,670 entitled CRISPR Effector System Based Coronavirus Diagnostics filed Jun. 5, 2020, and Ser. No. 16/894,664 entitled Rapid Diagnostics filed Jun. 5, 2020, each of which is incorporated by reference in their entirety.

All publications, published patent documents, and patent applications cited herein are hereby incorporated by reference to the same extent as though each individual publication, published patent document, or patent application was specifically and individually indicated as being incorporated by reference.

OVERVIEW

Embodiments herein are directed to systems and methods of detecting the presence of a target nucleic acid in a sample. In certain example embodiments, the systems and methods provide for single reaction (one-pot) detection of target nucleic acids. In certain example embodiments, extraction, amplification, and detection may take place under a single set of reaction buffer and reagent conditions. In certain example embodiments, detection is achieved using isothermal amplification (e.g. LAMP) only. In other example embodiments, detection of nucleic acids can utilize Cas proteins to provide improved reaction sensitivity and/or specificity. In one embodiment, isothermal amplification may be utilized with a thermostable CRISPR-Cas protein, with the combination of thermostable protein and isothermal amplification utilized to further improve reaction conditions and times for detection and diagnostics. Advantageous quick extraction approaches for the extraction of nucleic acids from a sample are also provided. Design of reaction conditions and reagents are provided for the identification of primers and reaction conditions, including concentration and content of reagents and additives, that enhance the detection systems and methods disclosed herein. Advantageously, the systems and methods can be provided in lateral flow or self-contained cartridge devices for rapid, point-of-care diagnostics. In certain embodiments, the detection assay can be provided on a cartridge or chip. A device system can be configured to receive the cartridge and conduct an assay.

In certain example embodiments, the Cas protein may be a Type V CRISPR-Cas, a Type VI CRISPR-Cas, or combination thereof. In certain example embodiments, the Type V or Type VI Cas protein is a thermostable case protein with a nuclease activity above at least 50° C. In certain example embodiments, the Cas protein is a Cas12b protein. In certain other example embodiments, the Cas12b is Alicyclobacillus acidiphilus (AapCas12b). In certain other example embodiments, the Cas12b protein is Brevibacillus sp. SYSU G02855 (BrCas12b). In certain example embodiments, the Cas protein, may be paired with the novel guide designs disclosed herein.

Systems and method disclosed herein include approaches to detection isothermal amplification for detection of target nucleic acids. In certain example embodiments, isothermal amplification approach is loop-mediated isothermal amplification (LAMP). Design of optimal systems, including primers, reagents and additives to be used with isothermal amplification approaches are also provided. Optionally, CRISPR-Cas systems as disclosed herein can be used with isothermal amplification approaches, including LAMP, that can enhance sensitivity and/or specificity.

Methods of designing optimal reaction conditions are also provided. In an aspect, methods can comprise identifying the type of amplification reaction and designing optimal primers in accordance with the methods disclosed herein. Methods may also comprise identifying optimum CRISPR-Cas systems, including identification of the Cas protein for the reactions conditions. For example, the Cas protein may be identified based on its thermostability, cutting preferences, or other desired charateristics. Preferred guide molecules may similarly be identified. Once one or more primers and/or guides are identified, salt concentrations and other additives can be titrated and selected for further investigation. Additional reaction conditions, additives and reagents can be identified to optimize the use of one-pot methodology, lyophilization of reagents, and use in the devices disclosed herein. In certain example embodiments, preferred optimized additives include taurine, glycine or magnesium.

In certain example embodiments, the system comprises a Type VI CRISPR-Cas system, one or more guide polynucleotides comprising a guide sequence capable of binding a target sequence and designed to form a complex with the Type VI Cas protein, and a detection construct comprising a polynucleotide component. The Type VI Cas proteins of the present systems and methods exhibits collateral RNase activity, cleaving the polynucleotide component of the detection construct once activated by the target sequence, which can generate a detectable signal.

Embodiments disclosed herein provide systems utilized in multiplex lateral flow devices and methods of use. In certain preferred embodiments, the guides utilized are designed to be highly active guide molecules, allowing for rapid and highly sensitive detection of coronavirus. In certain example embodiments, the systems can utilize general capture of antibody that was not bound by intact reporter RNAs as described in Gootenberg, et al., Science 360, 439-444 (2018). In other embodiments, the presently disclosed system can be designed for detecting two or more targets. When utilized with a lateral flow approach, two or more separate detection lines consisting of deposited materials that capture detection construct and a molecule specific to the deposited material, allows visualization of detectable signal (e.g. gain or loss) at detection lines due to collateral activity and cleavage of corresponding reporter oligonucleotide. Utilizing guide design that allows for design of highly active guide RNAs for use with the specific Cas protein of the systems for target sequences, for example, coronavirus is also provided. In certain embodiments, the time from processing of a sample in the current methods and using the presently claimed systems, from receipt of sample to detectable signal is less than 120 minutes, 110 minutes, 100 minutes, 90 minutes, 75 minutes, 60 minutes, 45 minutes, or 30 minutes.

Single Lysis Reaction Compositions

In certain aspects, embodiments disclosed herein are directed to compositions and kits that consolidate extraction-free lysis and amplification of target nucleic acids into a single reaction volume. In certain example embodiments, the extraction-free lysis reagents, e.g., extraction-free solution for isolating polynucleotides, can be used to extract nucleic acids from cells and/or viral particles. In contrast to existing protocols, the extraction-free lysis solution does not require isolation of the nucleic acid prior to further amplification. The extractaction-free lysis reagents may be mixed with amplification reagents such as standard RT-PCR amplification reactions. An example extraction-free lysis solution is described in Example 3.

In an embodiment, the extraction-free polynucleotide isolation solution, is referred to alternately as an extraction-free lysis reagent herein. In one embodiment, the extraction-free polynucleotide isolation solution is used for isolation of DNA or RNA without a separate extraction step. In an aspect, the polynucleotide isolation solution is a DNA extraction solution that is utilized for the extraction of RNA from a cell or virus particle.

In one embodiment, the extraction-free polynucleotide isolation solution is Quick Extract™ DNA Extraction Solution (QE09050), Lucigen, or QuickExtract Plant DNA Extraction Solution, Lucigen. In an embodiment, the solution allows for isolation of polynucleotides without the requirement of further extraction prior to further processing. In an aspect, the sample is diluted 2:1, 1:1 or 1:2 sample:DNA extraction solution. Advantageously, use of the QuickExtract DNA Extraction solution can be utilized for extraction of RNA. In one embodiment, the QuickExtract DNA Extraction solution can be utilized for extraction of viral RNA. In one embodiment, the QuickExtract DNA Extraction solution can be utilized for extraction-free isolation of SARS-CoV-2 with the compositions, systems and methods detailed herein in a one-pot solution.

In one embodiment, the extraction-free polynucleotide isolation solution is Plant Quick Extract solution. In one embodiment, the Plant Quick Extract solution is used with polynucleotide isolation beads. In an aspect the beads used are madnetic beads. In an embodiment, the polynucleotide islation solution, a KCl buffer and magnetic beads are utilized to allow a system that can be performed as a one pot method. In an aspect, the method using polynucleotide isolation solution, beads, and KCl buffer solution can be performed without washing steps or an extraction step.

In one example embodiments, the extraction-free lysis solution is combined with amplification reagents into a single volume. In an aspect, the amplification reagents are isothermal amplification reagents. In one embodiment, the isothermal amplification reagents are LAMP isothermal amplification reagents. The LAMP isothermal amplification reagents may include primers for the target nucleic acids discussed in further detail below. In an embodiment, the LAMP amplification reagents include primer sets selected from SEQ ID Nos: 1-40499.

TABLE 1A Index of Lamp Primers and Sequence Identifiers FIP BIP F3 F2 F1c B1c B2 B3 LF LB SEQ SEQ SEQ SEQ SEQ SEQ SEQ SEQ SEQ SEQ Gene Ref Ref. No. ID NO ID NO ID NO. ID NO. ID NO. ID NO. ID NO. ID NO. ID NO. ID NO. NC_038524 0 1 4377 8753 13129 17505 21881 26257 30633 37886 NC_038524 1 2 4378 8754 13130 17506 21882 26258 30634 35009 NC_038524 2 3 4379 8755 13131 17507 21883 26259 30635 35010 37887 NC_038524 3 4 4380 8756 13132 17508 21884 26260 30636 35011 NC_038524 4 5 4381 8757 13133 17509 21885 26261 30637 35012 37888 NC_038524 5 6 4382 8758 13134 17510 21886 26262 30638 35013 37889 NC_038524 6 7 4383 8759 13135 17511 21887 26263 30639 37890 NC_038524 7 8 4384 8760 13136 17512 21888 26264 30640 35014 37891 NC_038524 8 9 4385 8761 13137 17513 21889 26265 30641 35015 NC_038524 9 10 4386 8762 13138 17514 21890 26266 30642 35016 NC_038524 10 11 4387 8763 13139 17515 21891 26267 30643 37892 NC_038524 11 12 4388 8764 13140 17516 21892 26268 30644 35017 37893 NC_038524 12 13 4389 8765 13141 17517 21893 26269 30645 37894 NC_038524 13 14 4390 8766 13142 17518 21894 26270 30646 37895 NC_028125 14 15 4391 8767 13143 17519 21895 26271 30647 35018 NC_028125 15 16 4392 8768 13144 17520 21896 26272 30648 37896 NC_028125 16 17 4393 8769 13145 17521 21897 26273 30649 35019 37897 NC_028125 17 18 4394 8770 13146 17522 21898 26274 30650 37898 NC_028125 18 19 4395 8771 13147 17523 21899 26275 30651 35020 NC_028125 19 20 4396 8772 13148 17524 21900 26276 30652 35021 NC_028125 20 21 4397 8773 13149 17525 21901 26277 30653 35022 37899 NC_028125 21 22 4398 8774 13150 17526 21902 26278 30654 37900 NC_028125 22 23 4399 8775 13151 17527 21903 26279 30655 37901 NC_028125 23 24 4400 8776 13152 17528 21904 26280 30656 35023 37902 NC_028125 24 25 4401 8777 13153 17529 21905 26281 30657 37903 NC_028125 25 26 4402 8778 13154 17530 21906 26282 30658 35024 NC_028125 26 27 4403 8779 13155 17531 21907 26283 30659 37904 NC_028125 27 28 4404 8780 13156 17532 21908 26284 30660 37905 NC_030791 28 29 4405 8781 13157 17533 21909 26285 30661 37906 NC_030791 29 30 4406 8782 13158 17534 21910 26286 30662 35025 37907 NC_030791 30 31 4407 8783 13159 17535 21911 26287 30663 35026 NC_030791 31 32 4408 8784 13160 17536 21912 26288 30664 35027 37908 NC_030791 32 33 4409 8785 13161 17537 21913 26289 30665 35028 37909 NC_030791 33 34 4410 8786 13162 17538 21914 26290 30666 35029 37910 NC_030791 34 35 4411 8787 13163 17539 21915 26291 30667 35030 NC_030791 35 36 4412 8788 13164 17540 21916 26292 30668 35031 NC_030791 36 37 4413 8789 13165 17541 21917 26293 30669 35032 NC_030791 37 38 4414 8790 13166 17542 21918 26294 30670 37911 NC_030791 38 39 4415 8791 13167 17543 21919 26295 30671 35033 37912 NC_030791 39 40 4416 8792 13168 17544 21920 26296 30672 37913 NC_030791 40 41 4417 8793 13169 17545 21921 26297 30673 35034 37914 NC_030791 41 42 4418 8794 13170 17546 21922 26298 30674 35035 NC_030791 42 43 4419 8795 13171 17547 21923 26299 30675 37915 NC_030791 43 44 4420 8796 13172 17548 21924 26300 30676 37916 NC_030791 44 45 4421 8797 13173 17549 21925 26301 30677 35036 NC_030791 45 46 4422 8798 13174 17550 21926 26302 30678 35037 37917 NC_030791 46 47 4423 8799 13175 17551 21927 26303 30679 37918 NC_030791 47 48 4424 8800 13176 17552 21928 26304 30680 37919 NC_030791 48 49 4425 8801 13177 17553 21929 26305 30681 37920 NC_030791 49 50 4426 8802 13178 17554 21930 26306 30682 35038 37921 NC_030791 50 51 4427 8803 13179 17555 21931 26307 30683 37922 NC_030791 51 52 4428 8804 13180 17556 21932 26308 30684 37923 NC_030791 52 53 4429 8805 13181 17557 21933 26309 30685 35039 37924 NC_030791 53 54 4430 8806 13182 17558 21934 26310 30686 35040 NC_006312 54 55 4431 8807 13183 17559 21935 26311 30687 37925 NC_006312 55 56 4432 8808 13184 17560 21936 26312 30688 37926 NC_002204 56 57 4433 8809 13185 17561 21937 26313 30689 35041 NC_002204 57 58 4434 8810 13186 17562 21938 26314 30690 37927 NC_002204 58 59 4435 8811 13187 17563 21939 26315 30691 37928 NC_002204 59 60 4436 8812 13188 17564 21940 26316 30692 35042 NC_002204 60 61 4437 8813 13189 17565 21941 26317 30693 37929 NC_002204 61 62 4438 8814 13190 17566 21942 26318 30694 35043 37930 NC_007374 62 63 4439 8815 13191 17567 21943 26319 30695 35044 NC_007374 63 64 4440 8816 13192 17568 21944 26320 30696 35045 NC_007374 64 65 4441 8817 13193 17569 21945 26321 30697 35046 NC_007374 65 66 4442 8818 13194 17570 21946 26322 30698 35047 37931 NC_007374 66 67 4443 8819 13195 17571 21947 26323 30699 37932 NC_001803 67 68 4444 8820 13196 17572 21948 26324 30700 35048 NC_001803 68 69 4445 8821 13197 17573 21949 26325 30701 37933 NC_001803 69 70 4446 8822 13198 17574 21950 26326 30702 35049 NC_001803 70 71 4447 8823 13199 17575 21951 26327 30703 35050 NC_001803 71 72 4448 8824 13200 17576 21952 26328 30704 35051 37934 NC_001803 72 73 4449 8825 13201 17577 21953 26329 30705 37935 NC_001803 73 74 4450 8826 13202 17578 21954 26330 30706 37936 NC_001803 74 75 4451 8827 13203 17579 21955 26331 30707 35052 NC_001803 75 76 4452 8828 13204 17580 21956 26332 30708 35053 NC_001803 76 77 4453 8829 13205 17581 21957 26333 30709 35054 NC_001803 77 78 4454 8830 13206 17582 21958 26334 30710 35055 NC_001803 78 79 4455 8831 13207 17583 21959 26335 30711 37937 NC_001803 79 80 4456 8832 13208 17584 21960 26336 30712 37938 NC_001803 80 81 4457 8833 13209 17585 21961 26337 30713 35056 NC_001803 81 82 4458 8834 13210 17586 21962 26338 30714 35057 NC_001803 82 83 4459 8835 13211 17587 21963 26339 30715 35058 NC_001803 83 84 4460 8836 13212 17588 21964 26340 30716 37939 NC_001803 84 85 4461 8837 13213 17589 21965 26341 30717 37940 NC_001803 85 86 4462 8838 13214 17590 21966 26342 30718 35059 NC_001803 86 87 4463 8839 13215 17591 21967 26343 30719 37941 NC_038882 87 88 4464 8840 13216 17592 21968 26344 30720 35060 37942 NC_038882 88 89 4465 8841 13217 17593 21969 26345 30721 35061 37943 NC_038882 89 90 4466 8842 13218 17594 21970 26346 30722 35062 37944 NC_038882 90 91 4467 8843 13219 17595 21971 26347 30723 35063 NC_038882 91 92 4468 8844 13220 17596 21972 26348 30724 35064 NC_038882 92 93 4469 8845 13221 17597 21973 26349 30725 37945 NC_038882 93 94 4470 8846 13222 17598 21974 26350 30726 35065 37946 NC_038882 94 95 4471 8847 13223 17599 21975 26351 30727 35066 37947 NC_038882 95 96 4472 8848 13224 17600 21976 26352 30728 37948 NC_038882 96 97 4473 8849 13225 17601 21977 26353 30729 37949 NC_038882 97 98 4474 8850 13226 17602 21978 26354 30730 35067 NC_038882 98 99 4475 8851 13227 17603 21979 26355 30731 35068 37950 NC_038882 99 100 4476 8852 13228 17604 21980 26356 30732 37951 NC_038882 100 101 4477 8853 13229 17605 21981 26357 30733 35069 NC_038882 101 102 4478 8854 13230 17606 21982 26358 30734 37952 NC_038882 102 103 4479 8855 13231 17607 21983 26359 30735 35070 NC_038882 103 104 4480 8856 13232 17608 21984 26360 30736 37953 NC_038882 104 105 4481 8857 13233 17609 21985 26361 30737 35071 37954 NC_038882 105 106 4482 8858 13234 17610 21986 26362 30738 37955 NC_038882 106 107 4483 8859 13235 17611 21987 26363 30739 35072 37956 NC_038882 107 108 4484 8860 13236 17612 21988 26364 30740 37957 NC_038882 108 109 4485 8861 13237 17613 21989 26365 30741 35073 37958 NC_038882 109 110 4486 8862 13238 17614 21990 26366 30742 37959 NC_038882 110 111 4487 8863 13239 17615 21991 26367 30743 37960 NC_038882 111 112 4488 8864 13240 17616 21992 26368 30744 37961 NC_038882 112 113 4489 8865 13241 17617 21993 26369 30745 37962 NC_038882 113 114 4490 8866 13242 17618 21994 26370 30746 35074 NC_038882 114 115 4491 8867 13243 17619 21995 26371 30747 35075 37963 NC_038882 115 116 4492 8868 13244 17620 21996 26372 30748 37964 NC_007359 116 117 4493 8869 13245 17621 21997 26373 30749 35076 NC_007359 117 118 4494 8870 13246 17622 21998 26374 30750 35077 NC_007359 118 119 4495 8871 13247 17623 21999 26375 30751 35078 37965 NC_007359 119 120 4496 8872 13248 17624 22000 26376 30752 35079 NC_007359 120 121 4497 8873 13249 17625 22001 26377 30753 35080 NC_007359 121 122 4498 8874 13250 17626 22002 26378 30754 35081 37966 NC_007380 122 123 4499 8875 13251 17627 22003 26379 30755 35082 NC_007380 123 124 4500 8876 13252 17628 22004 26380 30756 37967 NC_001676 124 125 4501 8877 13253 17629 22005 26381 30757 35083 NC_001676 125 126 4502 8878 13254 17630 22006 26382 30758 37968 NC_001676 126 127 4503 8879 13255 17631 22007 26383 30759 35084 NC_001676 127 128 4504 8880 13256 17632 22008 26384 30760 35085 37969 NC_001676 128 129 4505 8881 13257 17633 22009 26385 30761 37970 NC_001676 129 130 4506 8882 13258 17634 22010 26386 30762 35086 NC_001676 130 131 4507 8883 13259 17635 22011 26387 30763 35087 37971 NC_001676 131 132 4508 8884 13260 17636 22012 26388 30764 37972 NC_001676 132 133 4509 8885 13261 17637 22013 26389 30765 37973 NC_001676 133 134 4510 8886 13262 17638 22014 26390 30766 35088 NC_001676 134 135 4511 8887 13263 17639 22015 26391 30767 37974 NC_001676 135 136 4512 8888 13264 17640 22016 26392 30768 37975 NC_001676 136 137 4513 8889 13265 17641 22017 26393 30769 37976 NC_001436 137 138 4514 8890 13266 17642 22018 26394 30770 35089 37977 NC_001436 138 139 4515 8891 13267 17643 22019 26395 30771 35090 NC_001436 139 140 4516 8892 13268 17644 22020 26396 30772 35091 37978 NC_001436 140 141 4517 8893 13269 17645 22021 26397 30773 37979 NC_001436 141 142 4518 8894 13270 17646 22022 26398 30774 37980 NC_001436 142 143 4519 8895 13271 17647 22023 26399 30775 37981 NC_001436 143 144 4520 8896 13272 17648 22024 26400 30776 35092 37982 NC_001436 144 145 4521 8897 13273 17649 22025 26401 30777 35093 37983 NC_001436 145 146 4522 8898 13274 17650 22026 26402 30778 37984 NC_001436 146 147 4523 8899 13275 17651 22027 26403 30779 35094 NC_001436 147 148 4524 8900 13276 17652 22028 26404 30780 35095 NC_001436 148 149 4525 8901 13277 17653 22029 26405 30781 35096 37985 NC_001436 149 150 4526 8902 13278 17654 22030 26406 30782 37986 NC_001436 150 151 4527 8903 13279 17655 22031 26407 30783 35097 37987 NC_001436 151 152 4528 8904 13280 17656 22032 26408 30784 37988 NC_001436 152 153 4529 8905 13281 17657 22033 26409 30785 35098 NC_001436 153 154 4530 8906 13282 17658 22034 26410 30786 37989 NC_001436 154 155 4531 8907 13283 17659 22035 26411 30787 37990 NC_001436 155 156 4532 8908 13284 17660 22036 26412 30788 37991 NC_001436 156 157 4533 8909 13285 17661 22037 26413 30789 35099 NC_001436 157 158 4534 8910 13286 17662 22038 26414 30790 35100 NC_001436 158 159 4535 8911 13287 17663 22039 26415 30791 35101 37992 NC_001436 159 160 4536 8912 13288 17664 22040 26416 30792 35102 NC_001436 160 161 4537 8913 13289 17665 22041 26417 30793 35103 NC_007378 161 162 4538 8914 13290 17666 22042 26418 30794 35104 37993 NC_007378 162 163 4539 8915 13291 17667 22043 26419 30795 35105 NC_007378 163 164 4540 8916 13292 17668 22044 26420 30796 37994 NC_007378 164 165 4541 8917 13293 17669 22045 26421 30797 37995 NC_007378 165 166 4542 8918 13294 17670 22046 26422 30798 35106 37996 NC_007378 166 167 4543 8919 13295 17671 22047 26423 30799 35107 NC_007378 167 168 4544 8920 13296 17672 22048 26424 30800 35108 NC_007378 168 169 4545 8921 13297 17673 22049 26425 30801 35109 37997 NC_007378 169 170 4546 8922 13298 17674 22050 26426 30802 37998 NC_002020 170 171 4547 8923 13299 17675 22051 26427 30803 35110 NC_002020 171 172 4548 8924 13300 17676 22052 26428 30804 35111 NC_026435 172 173 4549 8925 13301 17677 22053 26429 30805 35112 37999 NC_026435 173 174 4550 8926 13302 17678 22054 26430 30806 38000 NC_026435 174 175 4551 8927 13303 17679 22055 26431 30807 35113 38001 NC_026435 175 176 4552 8928 13304 17680 22056 26432 30808 35114 NC_026435 176 177 4553 8929 13305 17681 22057 26433 30809 35115 NC_026435 177 178 4554 8930 13306 17682 22058 26434 30810 38002 NC_026435 178 179 4555 8931 13307 17683 22059 26435 30811 35116 NC_006273 179 180 4556 8932 13308 17684 22060 26436 30812 35117 NC_006273 180 181 4557 8933 13309 17685 22061 26437 30813 35118 38003 NC_006273 181 182 4558 8934 13310 17686 22062 26438 30814 38004 NC_006273 182 183 4559 8935 13311 17687 22063 26439 30815 35119 NC_006273 183 184 4560 8936 13312 17688 22064 26440 30816 38005 NC_006273 184 185 4561 8937 13313 17689 22065 26441 30817 35120 NC_006273 185 186 4562 8938 13314 17690 22066 26442 30818 35121 NC_006273 186 187 4563 8939 13315 17691 22067 26443 30819 38006 NC_006273 187 188 4564 8940 13316 17692 22068 26444 30820 35122 NC_006273 188 189 4565 8941 13317 17693 22069 26445 30821 35123 38007 NC_006273 189 190 4566 8942 13318 17694 22070 26446 30822 35124 NC_006273 190 191 4567 8943 13319 17695 22071 26447 30823 35125 38008 NC_006273 191 192 4568 8944 13320 17696 22072 26448 30824 38009 NC_006273 192 193 4569 8945 13321 17697 22073 26449 30825 35126 NC_006273 193 194 4570 8946 13322 17698 22074 26450 30826 35127 38010 NC_006273 194 195 4571 8947 13323 17699 22075 26451 30827 38011 NC_006273 195 196 4572 8948 13324 17700 22076 26452 30828 38012 NC_006273 196 197 4573 8949 13325 17701 22077 26453 30829 35128 NC_006273 197 198 4574 8950 13326 17702 22078 26454 30830 38013 NC_006273 198 199 4575 8951 13327 17703 22079 26455 30831 35129 38014 NC_006273 199 200 4576 8952 13328 17704 22080 26456 30832 38015 NC_006273 200 201 4577 8953 13329 17705 22081 26457 30833 35130 38016 NC_006273 201 202 4578 8954 13330 17706 22082 26458 30834 35131 NC_006273 202 203 4579 8955 13331 17707 22083 26459 30835 38017 NC_006273 203 204 4580 8956 13332 17708 22084 26460 30836 35132 38018 NC_006273 204 205 4581 8957 13333 17709 22085 26461 30837 35133 38019 NC_006273 205 206 4582 8958 13334 17710 22086 26462 30838 35134 NC_006273 206 207 4583 8959 13335 17711 22087 26463 30839 35135 NC_006273 207 208 4584 8960 13336 17712 22088 26464 30840 35136 38020 NC_006273 208 209 4585 8961 13337 17713 22089 26465 30841 35137 38021 NC_006273 209 210 4586 8962 13338 17714 22090 26466 30842 38022 NC_006273 210 211 4587 8963 13339 17715 22091 26467 30843 38023 NC_006273 211 212 4588 8964 13340 17716 22092 26468 30844 38024 NC_006273 212 213 4589 8965 13341 17717 22093 26469 30845 38025 NC_006273 213 214 4590 8966 13342 17718 22094 26470 30846 35138 NC_006273 214 215 4591 8967 13343 17719 22095 26471 30847 35139 38026 NC_006273 215 216 4592 8968 13344 17720 22096 26472 30848 35140 NC_006273 216 217 4593 8969 13345 17721 22097 26473 30849 35141 38027 NC_006273 217 218 4594 8970 13346 17722 22098 26474 30850 35142 38028 NC_006273 218 219 4595 8971 13347 17723 22099 26475 30851 35143 38029 NC_006273 219 220 4596 8972 13348 17724 22100 26476 30852 35144 38030 NC_006273 220 221 4597 8973 13349 17725 22101 26477 30853 38031 NC_006273 221 222 4598 8974 13350 17726 22102 26478 30854 35145 38032 NC_006273 222 223 4599 8975 13351 17727 22103 26479 30855 35146 38033 NC_006273 223 224 4600 8976 13352 17728 22104 26480 30856 35147 38034 NC_006273 224 225 4601 8977 13353 17729 22105 26481 30857 35148 38035 NC_006273 225 226 4602 8978 13354 17730 22106 26482 30858 35149 38036 NC_006273 226 227 4603 8979 13355 17731 22107 26483 30859 35150 38037 NC_006273 227 228 4604 8980 13356 17732 22108 26484 30860 35151 NC_006273 228 229 4605 8981 13357 17733 22109 26485 30861 35152 38038 NC_006273 229 230 4606 8982 13358 17734 22110 26486 30862 35153 38039 NC_006273 230 231 4607 8983 13359 17735 22111 26487 30863 35154 38040 NC_006273 231 232 4608 8984 13360 17736 22112 26488 30864 38041 NC_006273 232 233 4609 8985 13361 17737 22113 26489 30865 35155 38042 NC_006273 233 234 4610 8986 13362 17738 22114 26490 30866 38043 NC_006273 234 235 4611 8987 13363 17739 22115 26491 30867 38044 NC_006273 235 236 4612 8988 13364 17740 22116 26492 30868 35156 38045 NC_006273 236 237 4613 8989 13365 17741 22117 26493 30869 35157 NC_006273 237 238 4614 8990 13366 17742 22118 26494 30870 35158 NC_006273 238 239 4615 8991 13367 17743 22119 26495 30871 35159 38046 NC_006273 239 240 4616 8992 13368 17744 22120 26496 30872 35160 38047 NC_006273 240 241 4617 8993 13369 17745 22121 26497 30873 35161 NC_006273 241 242 4618 8994 13370 17746 22122 26498 30874 35162 38048 NC_006273 242 243 4619 8995 13371 17747 22123 26499 30875 35163 NC_006273 243 244 4620 8996 13372 17748 22124 26500 30876 35164 NC_006273 244 245 4621 8997 13373 17749 22125 26501 30877 38049 NC_006273 245 246 4622 8998 13374 17750 22126 26502 30878 35165 NC_006273 246 247 4623 8999 13375 17751 22127 26503 30879 38050 NC_006273 247 248 4624 9000 13376 17752 22128 26504 30880 35166 NC_006273 248 249 4625 9001 13377 17753 22129 26505 30881 38051 NC_006273 249 250 4626 9002 13378 17754 22130 26506 30882 35167 38052 NC_006273 250 251 4627 9003 13379 17755 22131 26507 30883 35168 NC_006273 251 252 4628 9004 13380 17756 22132 26508 30884 38053 NC_006273 252 253 4629 9005 13381 17757 22133 26509 30885 35169 38054 NC_006273 253 254 4630 9006 13382 17758 22134 26510 30886 38055 NC_006273 254 255 4631 9007 13383 17759 22135 26511 30887 38056 NC_006273 255 256 4632 9008 13384 17760 22136 26512 30888 35170 NC_006273 256 257 4633 9009 13385 17761 22137 26513 30889 35171 NC_006273 257 258 4634 9010 13386 17762 22138 26514 30890 35172 NC_006273 258 259 4635 9011 13387 17763 22139 26515 30891 35173 38057 NC_006273 259 260 4636 9012 13388 17764 22140 26516 30892 35174 38058 NC_006273 260 261 4637 9013 13389 17765 22141 26517 30893 35175 NC_006273 261 262 4638 9014 13390 17766 22142 26518 30894 35176 NC_006273 262 263 4639 9015 13391 17767 22143 26519 30895 35177 38059 NC_006273 263 264 4640 9016 13392 17768 22144 26520 30896 38060 NC_006273 264 265 4641 9017 13393 17769 22145 26521 30897 35178 38061 NC_006273 265 266 4642 9018 13394 17770 22146 26522 30898 35179 38062 NC_006273 266 267 4643 9019 13395 17771 22147 26523 30899 35180 38063 NC_006273 267 268 4644 9020 13396 17772 22148 26524 30900 38064 NC_006273 268 269 4645 9021 13397 17773 22149 26525 30901 38065 NC_006273 269 270 4646 9022 13398 17774 22150 26526 30902 35181 NC_006273 270 271 4647 9023 13399 17775 22151 26527 30903 35182 38066 NC_006273 271 272 4648 9024 13400 17776 22152 26528 30904 35183 38067 NC_006273 272 273 4649 9025 13401 17777 22153 26529 30905 35184 38068 NC_006273 273 274 4650 9026 13402 17778 22154 26530 30906 35185 38069 NC_006273 274 275 4651 9027 13403 17779 22155 26531 30907 35186 NC_006273 275 276 4652 9028 13404 17780 22156 26532 30908 35187 38070 NC_006273 276 277 4653 9029 13405 17781 22157 26533 30909 38071 NC_006273 277 278 4654 9030 13406 17782 22158 26534 30910 35188 NC_006273 278 279 4655 9031 13407 17783 22159 26535 30911 35189 38072 NC_006273 279 280 4656 9032 13408 17784 22160 26536 30912 35190 38073 NC_006273 280 281 4657 9033 13409 17785 22161 26537 30913 35191 38074 NC_006273 281 282 4658 9034 13410 17786 22162 26538 30914 35192 38075 NC_006273 282 283 4659 9035 13411 17787 22163 26539 30915 35193 38076 NC_006273 283 284 4660 9036 13412 17788 22164 26540 30916 35194 38077 NC_006273 284 285 4661 9037 13413 17789 22165 26541 30917 35195 NC_006273 285 286 4662 9038 13414 17790 22166 26542 30918 35196 38078 NC_006273 286 287 4663 9039 13415 17791 22167 26543 30919 35197 NC_006273 287 288 4664 9040 13416 17792 22168 26544 30920 35198 38079 NC_006273 288 289 4665 9041 13417 17793 22169 26545 30921 35199 38080 NC_006273 289 290 4666 9042 13418 17794 22170 26546 30922 38081 NC_006273 290 291 4667 9043 13419 17795 22171 26547 30923 38082 NC_006273 291 292 4668 9044 13420 17796 22172 26548 30924 35200 38083 NC_006273 292 293 4669 9045 13421 17797 22173 26549 30925 35201 38084 NC_006273 293 294 4670 9046 13422 17798 22174 26550 30926 38085 NC_006273 294 295 4671 9047 13423 17799 22175 26551 30927 35202 38086 NC_006273 295 296 4672 9048 13424 17800 22176 26552 30928 35203 NC_006273 296 297 4673 9049 13425 17801 22177 26553 30929 38087 NC_006273 297 298 4674 9050 13426 17802 22178 26554 30930 35204 NC_006273 298 299 4675 9051 13427 17803 22179 26555 30931 35205 NC_006273 299 300 4676 9052 13428 17804 22180 26556 30932 38088 NC_006273 300 301 4677 9053 13429 17805 22181 26557 30933 35206 38089 NC_006273 301 302 4678 9054 13430 17806 22182 26558 30934 35207 NC_006273 302 303 4679 9055 13431 17807 22183 26559 30935 35208 38090 NC_006273 303 304 4680 9056 13432 17808 22184 26560 30936 35209 38091 NC_006273 304 305 4681 9057 13433 17809 22185 26561 30937 35210 38092 NC_006273 305 306 4682 9058 13434 17810 22186 26562 30938 35211 38093 NC_006273 306 307 4683 9059 13435 17811 22187 26563 30939 35212 NC_006273 307 308 4684 9060 13436 17812 22188 26564 30940 38094 NC_006273 308 309 4685 9061 13437 17813 22189 26565 30941 35213 NC_006273 309 310 4686 9062 13438 17814 22190 26566 30942 35214 NC_006273 310 311 4687 9063 13439 17815 22191 26567 30943 38095 NC_006273 311 312 4688 9064 13440 17816 22192 26568 30944 35215 38096 NC_006273 312 313 4689 9065 13441 17817 22193 26569 30945 35216 38097 NC_006273 313 314 4690 9066 13442 17818 22194 26570 30946 35217 NC_006273 314 315 4691 9067 13443 17819 22195 26571 30947 35218 NC_006273 315 316 4692 9068 13444 17820 22196 26572 30948 35219 38098 NC_006273 316 317 4693 9069 13445 17821 22197 26573 30949 35220 NC_006273 317 318 4694 9070 13446 17822 22198 26574 30950 38099 NC_006273 318 319 4695 9071 13447 17823 22199 26575 30951 35221 NC_006273 319 320 4696 9072 13448 17824 22200 26576 30952 35222 NC_006273 320 321 4697 9073 13449 17825 22201 26577 30953 35223 NC_006273 321 322 4698 9074 13450 17826 22202 26578 30954 35224 38100 NC_006273 322 323 4699 9075 13451 17827 22203 26579 30955 35225 38101 NC_006273 323 324 4700 9076 13452 17828 22204 26580 30956 35226 NC_006273 324 325 4701 9077 13453 17829 22205 26581 30957 35227 38102 NC_006273 325 326 4702 9078 13454 17830 22206 26582 30958 35228 NC_006273 326 327 4703 9079 13455 17831 22207 26583 30959 35229 38103 NC_006273 327 328 4704 9080 13456 17832 22208 26584 30960 38104 NC_006273 328 329 4705 9081 13457 17833 22209 26585 30961 35230 NC_006273 329 330 4706 9082 13458 17834 22210 26586 30962 35231 38105 NC_006273 330 331 4707 9083 13459 17835 22211 26587 30963 38106 NC_006273 331 332 4708 9084 13460 17836 22212 26588 30964 38107 NC_006273 332 333 4709 9085 13461 17837 22213 26589 30965 38108 NC_006273 333 334 4710 9086 13462 17838 22214 26590 30966 35232 NC_006273 334 335 4711 9087 13463 17839 22215 26591 30967 35233 38109 NC_006273 335 336 4712 9088 13464 17840 22216 26592 30968 35234 38110 NC_006273 336 337 4713 9089 13465 17841 22217 26593 30969 35235 38111 NC_006273 337 338 4714 9090 13466 17842 22218 26594 30970 35236 NC_006273 338 339 4715 9091 13467 17843 22219 26595 30971 35237 NC_006273 339 340 4716 9092 13468 17844 22220 26596 30972 35238 38112 NC_006273 340 341 4717 9093 13469 17845 22221 26597 30973 35239 38113 NC_006273 341 342 4718 9094 13470 17846 22222 26598 30974 35240 38114 NC_006273 342 343 4719 9095 13471 17847 22223 26599 30975 35241 38115 NC_006273 343 344 4720 9096 13472 17848 22224 26600 30976 35242 38116 NC_006273 344 345 4721 9097 13473 17849 22225 26601 30977 35243 38117 NC_006273 345 346 4722 9098 13474 17850 22226 26602 30978 35244 38118 NC_006273 346 347 4723 9099 13475 17851 22227 26603 30979 35245 38119 NC_006273 347 348 4724 9100 13476 17852 22228 26604 30980 35246 38120 NC_006273 348 349 4725 9101 13477 17853 22229 26605 30981 35247 NC_006273 349 350 4726 9102 13478 17854 22230 26606 30982 38121 NC_006273 350 351 4727 9103 13479 17855 22231 26607 30983 35248 NC_006273 351 352 4728 9104 13480 17856 22232 26608 30984 38122 NC_006273 352 353 4729 9105 13481 17857 22233 26609 30985 38123 NC_006273 353 354 4730 9106 13482 17858 22234 26610 30986 35249 38124 NC_006273 354 355 4731 9107 13483 17859 22235 26611 30987 38125 NC_006273 355 356 4732 9108 13484 17860 22236 26612 30988 38126 NC_004912 356 357 4733 9109 13485 17861 22237 26613 30989 35250 NC_004912 357 358 4734 9110 13486 17862 22238 26614 30990 35251 38127 NC_004912 358 359 4735 9111 13487 17863 22239 26615 30991 35252 NC_004912 359 360 4736 9112 13488 17864 22240 26616 30992 35253 NC_004912 360 361 4737 9113 13489 17865 22241 26617 30993 38128 NC_004912 361 362 4738 9114 13490 17866 22242 26618 30994 38129 NC_004912 362 363 4739 9115 13491 17867 22243 26619 30995 38130 NC_026426 363 364 4740 9116 13492 17868 22244 26620 30996 38131 NC_026426 364 365 4741 9117 13493 17869 22245 26621 30997 38132 NC_026426 365 366 4742 9118 13494 17870 22246 26622 30998 38133 NC_026426 366 367 4743 9119 13495 17871 22247 26623 30999 35254 NC_001460 367 368 4744 9120 13496 17872 22248 26624 31000 38134 NC_001460 368 369 4745 9121 13497 17873 22249 26625 31001 35255 NC_001460 369 370 4746 9122 13498 17874 22250 26626 31002 38135 NC_001460 370 371 4747 9123 13499 17875 22251 26627 31003 35256 38136 NC_001460 371 372 4748 9124 13500 17876 22252 26628 31004 35257 NC_001460 372 373 4749 9125 13501 17877 22253 26629 31005 35258 NC_001460 373 374 4750 9126 13502 17878 22254 26630 31006 35259 NC_001460 374 375 4751 9127 13503 17879 22255 26631 31007 38137 NC_001460 375 376 4752 9128 13504 17880 22256 26632 31008 38138 NC_001460 376 377 4753 9129 13505 17881 22257 26633 31009 35260 NC_001460 377 378 4754 9130 13506 17882 22258 26634 31010 35261 38139 NC_001460 378 379 4755 9131 13507 17883 22259 26635 31011 38140 NC_001460 379 380 4756 9132 13508 17884 22260 26636 31012 35262 NC_001460 380 381 4757 9133 13509 17885 22261 26637 31013 38141 NC_001460 381 382 4758 9134 13510 17886 22262 26638 31014 35263 NC_001460 382 383 4759 9135 13511 17887 22263 26639 31015 35264 38142 NC_001460 383 384 4760 9136 13512 17888 22264 26640 31016 38143 NC_001460 384 385 4761 9137 13513 17889 22265 26641 31017 35265 38144 NC_001460 385 386 4762 9138 13514 17890 22266 26642 31018 38145 NC_001460 386 387 4763 9139 13515 17891 22267 26643 31019 35266 38146 NC_001460 387 388 4764 9140 13516 17892 22268 26644 31020 38147 NC_001460 388 389 4765 9141 13517 17893 22269 26645 31021 35267 NC_001460 389 390 4766 9142 13518 17894 22270 26646 31022 38148 NC_001460 390 391 4767 9143 13519 17895 22271 26647 31023 35268 38149 NC_001460 391 392 4768 9144 13520 17896 22272 26648 31024 35269 38150 NC_001460 392 393 4769 9145 13521 17897 22273 26649 31025 35270 NC_001460 393 394 4770 9146 13522 17898 22274 26650 31026 35271 NC_001460 394 395 4771 9147 13523 17899 22275 26651 31027 38151 NC_001460 395 396 4772 9148 13524 17900 22276 26652 31028 35272 38152 NC_001460 396 397 4773 9149 13525 17901 22277 26653 31029 38153 NC_001460 397 398 4774 9150 13526 17902 22278 26654 31030 35273 38154 NC_001460 398 399 4775 9151 13527 17903 22279 26655 31031 35274 38155 NC_001460 399 400 4776 9152 13528 17904 22280 26656 31032 38156 NC_001460 400 401 4777 9153 13529 17905 22281 26657 31033 38157 NC_001460 401 402 4778 9154 13530 17906 22282 26658 31034 35275 NC_001460 402 403 4779 9155 13531 17907 22283 26659 31035 35276 NC_001460 403 404 4780 9156 13532 17908 22284 26660 31036 35277 38158 NC_001460 404 405 4781 9157 13533 17909 22285 26661 31037 35278 NC_001460 405 406 4782 9158 13534 17910 22286 26662 31038 35279 NC_001460 406 407 4783 9159 13535 17911 22287 26663 31039 35280 38159 NC_001460 407 408 4784 9160 13536 17912 22288 26664 31040 38160 NC_001460 408 409 4785 9161 13537 17913 22289 26665 31041 35281 38161 NC_001460 409 410 4786 9162 13538 17914 22290 26666 31042 38162 NC_001460 410 411 4787 9163 13539 17915 22291 26667 31043 35282 38163 NC_001460 411 412 4788 9164 13540 17916 22292 26668 31044 35283 38164 NC_001460 412 413 4789 9165 13541 17917 22293 26669 31045 35284 38165 NC_001460 413 414 4790 9166 13542 17918 22294 26670 31046 38166 NC_001460 414 415 4791 9167 13543 17919 22295 26671 31047 38167 NC_001460 415 416 4792 9168 13544 17920 22296 26672 31048 35285 NC_001460 416 417 4793 9169 13545 17921 22297 26673 31049 38168 NC_001460 417 418 4794 9170 13546 17922 22298 26674 31050 35286 NC_001460 418 419 4795 9171 13547 17923 22299 26675 31051 35287 NC_001460 419 420 4796 9172 13548 17924 22300 26676 31052 38169 NC_001460 420 421 4797 9173 13549 17925 22301 26677 31053 38170 NC_001460 421 422 4798 9174 13550 17926 22302 26678 31054 38171 NC_001460 422 423 4799 9175 13551 17927 22303 26679 31055 35288 NC_001460 423 424 4800 9176 13552 17928 22304 26680 31056 35289 NC_001460 424 425 4801 9177 13553 17929 22305 26681 31057 35290 38172 NC_001460 425 426 4802 9178 13554 17930 22306 26682 31058 35291 NC_001460 426 427 4803 9179 13555 17931 22307 26683 31059 35292 38173 NC_001460 427 428 4804 9180 13556 17932 22308 26684 31060 35293 38174 NC_001460 428 429 4805 9181 13557 17933 22309 26685 31061 35294 NC_001460 429 430 4806 9182 13558 17934 22310 26686 31062 35295 38175 NC_001460 430 431 4807 9183 13559 17935 22311 26687 31063 35296 NC_001460 431 432 4808 9184 13560 17936 22312 26688 31064 35297 38176 NC_001460 432 433 4809 9185 13561 17937 22313 26689 31065 35298 38177 NC_001460 433 434 4810 9186 13562 17938 22314 26690 31066 38178 NC_001460 434 435 4811 9187 13563 17939 22315 26691 31067 35299 NC_001460 435 436 4812 9188 13564 17940 22316 26692 31068 38179 NC_001460 436 437 4813 9189 13565 17941 22317 26693 31069 35300 NC_001460 437 438 4814 9190 13566 17942 22318 26694 31070 38180 NC_001460 438 439 4815 9191 13567 17943 22319 26695 31071 38181 NC_001460 439 440 4816 9192 13568 17944 22320 26696 31072 38182 NC_001460 440 441 4817 9193 13569 17945 22321 26697 31073 35301 NC_001460 441 442 4818 9194 13570 17946 22322 26698 31074 38183 NC_001460 442 443 4819 9195 13571 17947 22323 26699 31075 35302 38184 NC_001460 443 444 4820 9196 13572 17948 22324 26700 31076 38185 NC_001460 444 445 4821 9197 13573 17949 22325 26701 31077 38186 NC_001460 445 446 4822 9198 13574 17950 22326 26702 31078 38187 NC_001460 446 447 4823 9199 13575 17951 22327 26703 31079 35303 NC_001460 447 448 4824 9200 13576 17952 22328 26704 31080 35304 NC_001460 448 449 4825 9201 13577 17953 22329 26705 31081 35305 NC_001460 449 450 4826 9202 13578 17954 22330 26706 31082 35306 NC_001460 450 451 4827 9203 13579 17955 22331 26707 31083 35307 NC_001460 451 452 4828 9204 13580 17956 22332 26708 31084 38188 NC_001460 452 453 4829 9205 13581 17957 22333 26709 31085 38189 NC_001460 453 454 4830 9206 13582 17958 22334 26710 31086 35308 NC_001460 454 455 4831 9207 13583 17959 22335 26711 31087 35309 NC_001460 455 456 4832 9208 13584 17960 22336 26712 31088 38190 NC_001460 456 457 4833 9209 13585 17961 22337 26713 31089 35310 NC_038878 457 458 4834 9210 13586 17962 22338 26714 31090 35311 NC_038878 458 459 4835 9211 13587 17963 22339 26715 31091 35312 NC_038878 459 460 4836 9212 13588 17964 22340 26716 31092 35313 NC_038878 460 461 4837 9213 13589 17965 22341 26717 31093 38191 NC_038878 461 462 4838 9214 13590 17966 22342 26718 31094 35314 38192 NC_038878 462 463 4839 9215 13591 17967 22343 26719 31095 35315 NC_038878 463 464 4840 9216 13592 17968 22344 26720 31096 35316 NC_038878 464 465 4841 9217 13593 17969 22345 26721 31097 35317 NC_038878 465 466 4842 9218 13594 17970 22346 26722 31098 38193 NC_038878 466 467 4843 9219 13595 17971 22347 26723 31099 35318 NC_038878 467 468 4844 9220 13596 17972 22348 26724 31100 35319 NC_038878 468 469 4845 9221 13597 17973 22349 26725 31101 35320 NC_038878 469 470 4846 9222 13598 17974 22350 26726 31102 35321 NC_038878 470 471 4847 9223 13599 17975 22351 26727 31103 38194 NC_038878 471 472 4848 9224 13600 17976 22352 26728 31104 35322 NC_001457 472 473 4849 9225 13601 17977 22353 26729 31105 38195 NC_001457 473 474 4850 9226 13602 17978 22354 26730 31106 35323 38196 NC_001457 474 475 4851 9227 13603 17979 22355 26731 31107 35324 NC_001457 475 476 4852 9228 13604 17980 22356 26732 31108 35325 NC_001457 476 477 4853 9229 13605 17981 22357 26733 31109 35326 NC_001457 477 478 4854 9230 13606 17982 22358 26734 31110 35327 NC_001457 478 479 4855 9231 13607 17983 22359 26735 31111 38197 NC_001457 479 480 4856 9232 13608 17984 22360 26736 31112 35328 NC_001457 480 481 4857 9233 13609 17985 22361 26737 31113 38198 NC_001457 481 482 4858 9234 13610 17986 22362 26738 31114 38199 NC_001457 482 483 4859 9235 13611 17987 22363 26739 31115 35329 NC_001457 483 484 4860 9236 13612 17988 22364 26740 31116 35330 38200 NC_001457 484 485 4861 9237 13613 17989 22365 26741 31117 35331 38201 NC_001457 485 486 4862 9238 13614 17990 22366 26742 31118 35332 NC_001457 486 487 4863 9239 13615 17991 22367 26743 31119 38202 NC_001457 487 488 4864 9240 13616 17992 22368 26744 31120 38203 NC_001457 488 489 4865 9241 13617 17993 22369 26745 31121 38204 NC_001457 489 490 4866 9242 13618 17994 22370 26746 31122 38205 NC_001716 490 491 4867 9243 13619 17995 22371 26747 31123 35333 38206 NC_001716 491 492 4868 9244 13620 17996 22372 26748 31124 35334 NC_001716 492 493 4869 9245 13621 17997 22373 26749 31125 38207 NC_001716 493 494 4870 9246 13622 17998 22374 26750 31126 35335 38208 NC_006308 494 495 4871 9247 13623 17999 22375 26751 31127 35336 NC_006308 495 496 4872 9248 13624 18000 22376 26752 31128 35337 NC_006308 496 497 4873 9249 13625 18001 22377 26753 31129 35338 NC_006308 497 498 4874 9250 13626 18002 22378 26754 31130 35339 NC_006308 498 499 4875 9251 13627 18003 22379 26755 31131 35340 38209 NC_001355 499 500 4876 9252 13628 18004 22380 26756 31132 35341 NC_001355 500 501 4877 9253 13629 18005 22381 26757 31133 38210 NC_001355 501 502 4878 9254 13630 18006 22382 26758 31134 38211 NC_001355 502 503 4879 9255 13631 18007 22383 26759 31135 35342 38212 NC_001355 503 504 4880 9256 13632 18008 22384 26760 31136 38213 NC_001355 504 505 4881 9257 13633 18009 22385 26761 31137 35343 NC_001355 505 506 4882 9258 13634 18010 22386 26762 31138 35344 NC_001355 506 507 4883 9259 13635 18011 22387 26763 31139 38214 NC_001355 507 508 4884 9260 13636 18012 22388 26764 31140 35345 NC_001355 508 509 4885 9261 13637 18013 22389 26765 31141 38215 NC_001355 509 510 4886 9262 13638 18014 22390 26766 31142 35346 NC_001355 510 511 4887 9263 13639 18015 22391 26767 31143 35347 NC_001355 511 512 4888 9264 13640 18016 22392 26768 31144 35348 38216 NC_001355 512 513 4889 9265 13641 18017 22393 26769 31145 35349 NC_001355 513 514 4890 9266 13642 18018 22394 26770 31146 35350 NC_001355 514 515 4891 9267 13643 18019 22395 26771 31147 35351 NC_001355 515 516 4892 9268 13644 18020 22396 26772 31148 35352 NC_001355 516 517 4893 9269 13645 18021 22397 26773 31149 35353 NC_009825 517 518 4894 9270 13646 18022 22398 26774 31150 38217 NC_009825 518 519 4895 9271 13647 18023 22399 26775 31151 35354 38218 NC_009825 519 520 4896 9272 13648 18024 22400 26776 31152 38219 NC_009825 520 521 4897 9273 13649 18025 22401 26777 31153 35355 38220 NC_009825 521 522 4898 9274 13650 18026 22402 26778 31154 38221 NC_009825 522 523 4899 9275 13651 18027 22403 26779 31155 35356 38222 NC_009825 523 524 4900 9276 13652 18028 22404 26780 31156 38223 NC_009825 524 525 4901 9277 13653 18029 22405 26781 31157 35357 NC_009825 525 526 4902 9278 13654 18030 22406 26782 31158 35358 38224 NC_009825 526 527 4903 9279 13655 18031 22407 26783 31159 35359 NC_009825 527 528 4904 9280 13656 18032 22408 26784 31160 35360 38225 NC_009825 528 529 4905 9281 13657 18033 22409 26785 31161 38226 NC_009825 529 530 4906 9282 13658 18034 22410 26786 31162 35361 38227 NC_009825 530 531 4907 9283 13659 18035 22411 26787 31163 38228 NC_009825 531 532 4908 9284 13660 18036 22412 26788 31164 35362 NC_009825 532 533 4909 9285 13661 18037 22413 26789 31165 38229 NC_009825 533 534 4910 9286 13662 18038 22414 26790 31166 35363 38230 NC_009825 534 535 4911 9287 13663 18039 22415 26791 31167 35364 38231 NC_009825 535 536 4912 9288 13664 18040 22416 26792 31168 38232 NC_009825 536 537 4913 9289 13665 18041 22417 26793 31169 35365 NC_009825 537 538 4914 9290 13666 18042 22418 26794 31170 38233 NC_009825 538 539 4915 9291 13667 18043 22419 26795 31171 35366 NC_009825 539 540 4916 9292 13668 18044 22420 26796 31172 35367 NC_009825 540 541 4917 9293 13669 18045 22421 26797 31173 35368 NC_009825 541 542 4918 9294 13670 18046 22422 26798 31174 35369 NC_009825 542 543 4919 9295 13671 18047 22423 26799 31175 38234 NC_009825 543 544 4920 9296 13672 18048 22424 26800 31176 35370 38235 NC_009825 544 545 4921 9297 13673 18049 22425 26801 31177 38236 NC_009825 545 546 4922 9298 13674 18050 22426 26802 31178 38237 NC_001490 546 547 4923 9299 13675 18051 22427 26803 31179 35371 NC_001490 547 548 4924 9300 13676 18052 22428 26804 31180 38238 NC_001490 548 549 4925 9301 13677 18053 22429 26805 31181 35372 NC_001490 549 550 4926 9302 13678 18054 22430 26806 31182 35373 NC_001490 550 551 4927 9303 13679 18055 22431 26807 31183 35374 NC_001490 551 552 4928 9304 13680 18056 22432 26808 31184 38239 NC_001490 552 553 4929 9305 13681 18057 22433 26809 31185 35375 NC_001490 553 554 4930 9306 13682 18058 22434 26810 31186 35376 NC_001490 554 555 4931 9307 13683 18059 22435 26811 31187 35377 NC_001490 555 556 4932 9308 13684 18060 22436 26812 31188 35378 38240 NC_001490 556 557 4933 9309 13685 18061 22437 26813 31189 35379 38241 NC_001490 557 558 4934 9310 13686 18062 22438 26814 31190 35380 NC_001490 558 559 4935 9311 13687 18063 22439 26815 31191 38242 NC_001490 559 560 4936 9312 13688 18064 22440 26816 31192 35381 NC_001490 560 561 4937 9313 13689 18065 22441 26817 31193 35382 38243 NC_001490 561 562 4938 9314 13690 18066 22442 26818 31194 35383 NC_001490 562 563 4939 9315 13691 18067 22443 26819 31195 38244 NC_026817 563 564 4940 9316 13692 18068 22444 26820 31196 38245 NC_026817 564 565 4941 9317 13693 18069 22445 26821 31197 35384 38246 NC_026817 565 566 4942 9318 13694 18070 22446 26822 31198 38247 NC_026817 566 567 4943 9319 13695 18071 22447 26823 31199 35385 NC_026817 567 568 4944 9320 13696 18072 22448 26824 31200 35386 38248 NC_017996 568 569 4945 9321 13697 18073 22449 26825 31201 38249 NC_017996 569 570 4946 9322 13698 18074 22450 26826 31202 38250 NC_017996 570 571 4947 9323 13699 18075 22451 26827 31203 38251 NC_017996 571 572 4948 9324 13700 18076 22452 26828 31204 35387 NC_017996 572 573 4949 9325 13701 18077 22453 26829 31205 38252 NC_017996 573 574 4950 9326 13702 18078 22454 26830 31206 35388 NC_017996 574 575 4951 9327 13703 18079 22455 26831 31207 35389 NC_017996 575 576 4952 9328 13704 18080 22456 26832 31208 35390 NC_017996 576 577 4953 9329 13705 18081 22457 26833 31209 38253 NC_017996 577 578 4954 9330 13706 18082 22458 26834 31210 38254 NC_017996 578 579 4955 9331 13707 18083 22459 26835 31211 38255 NC_017996 579 580 4956 9332 13708 18084 22460 26836 31212 35391 NC_017996 580 581 4957 9333 13709 18085 22461 26837 31213 35392 NC_017996 581 582 4958 9334 13710 18086 22462 26838 31214 38256 NC_017996 582 583 4959 9335 13711 18087 22463 26839 31215 35393 NC_017996 583 584 4960 9336 13712 18088 22464 26840 31216 35394 NC_001434 584 585 4961 9337 13713 18089 22465 26841 31217 35395 38257 NC_001434 585 586 4962 9338 13714 18090 22466 26842 31218 35396 NC_001434 586 587 4963 9339 13715 18091 22467 26843 31219 35397 38258 NC_001434 587 588 4964 9340 13716 18092 22468 26844 31220 35398 38259 NC_001434 588 589 4965 9341 13717 18093 22469 26845 31221 38260 NC_001434 589 590 4966 9342 13718 18094 22470 26846 31222 35399 NC_001434 590 591 4967 9343 13719 18095 22471 26847 31223 38261 NC_001434 591 592 4968 9344 13720 18096 22472 26848 31224 38262 NC_001434 592 593 4969 9345 13721 18097 22473 26849 31225 35400 38263 NC_001434 593 594 4970 9346 13722 18098 22474 26850 31226 35401 38264 NC_001434 594 595 4971 9347 13723 18099 22475 26851 31227 38265 NC_001434 595 596 4972 9348 13724 18100 22476 26852 31228 35402 38266 NC_001434 596 597 4973 9349 13725 18101 22477 26853 31229 35403 NC_001434 597 598 4974 9350 13726 18102 22478 26854 31230 35404 38267 NC_001434 598 599 4975 9351 13727 18103 22479 26855 31231 35405 NC_001434 599 600 4976 9352 13728 18104 22480 26856 31232 38268 NC_001434 600 601 4977 9353 13729 18105 22481 26857 31233 38269 NC_001434 601 602 4978 9354 13730 18106 22482 26858 31234 35406 38270 NC_001434 602 603 4979 9355 13731 18107 22483 26859 31235 35407 NC_001434 603 604 4980 9356 13732 18108 22484 26860 31236 35408 38271 NC_001348 604 605 4981 9357 13733 18109 22485 26861 31237 35409 NC_001348 605 606 4982 9358 13734 18110 22486 26862 31238 38272 NC_001348 606 607 4983 9359 13735 18111 22487 26863 31239 38273 NC_001348 607 608 4984 9360 13736 18112 22488 26864 31240 38274 NC_001348 608 609 4985 9361 13737 18113 22489 26865 31241 35410 NC_001348 609 610 4986 9362 13738 18114 22490 26866 31242 38275 NC_001348 610 611 4987 9363 13739 18115 22491 26867 31243 38276 NC_001348 611 612 4988 9364 13740 18116 22492 26868 31244 38277 NC_001348 612 613 4989 9365 13741 18117 22493 26869 31245 35411 NC_001348 613 614 4990 9366 13742 18118 22494 26870 31246 35412 NC_001348 614 615 4991 9367 13743 18119 22495 26871 31247 35413 NC_001348 615 616 4992 9368 13744 18120 22496 26872 31248 35414 NC_001348 616 617 4993 9369 13745 18121 22497 26873 31249 35415 38278 NC_001348 617 618 4994 9370 13746 18122 22498 26874 31250 35416 NC_001348 618 619 4995 9371 13747 18123 22499 26875 31251 38279 NC_001348 619 620 4996 9372 13748 18124 22500 26876 31252 35417 38280 NC_001802 620 621 4997 9373 13749 18125 22501 26877 31253 35418 NC_001802 621 622 4998 9374 13750 18126 22502 26878 31254 38281 NC_001802 622 623 4999 9375 13751 18127 22503 26879 31255 35419 NC_001802 623 624 5000 9376 13752 18128 22504 26880 31256 38282 NC_001802 624 625 5001 9377 13753 18129 22505 26881 31257 35420 NC_001802 625 626 5002 9378 13754 18130 22506 26882 31258 35421 NC_001802 626 627 5003 9379 13755 18131 22507 26883 31259 38283 NC_001802 627 628 5004 9380 13756 18132 22508 26884 31260 35422 NC_001802 628 629 5005 9381 13757 18133 22509 26885 31261 35423 NC_001802 629 630 5006 9382 13758 18134 22510 26886 31262 35424 NC_001802 630 631 5007 9383 13759 18135 22511 26887 31263 35425 38284 NC_001802 631 632 5008 9384 13760 18136 22512 26888 31264 35426 38285 NC_001802 632 633 5009 9385 13761 18137 22513 26889 31265 38286 NC_001802 633 634 5010 9386 13762 18138 22514 26890 31266 35427 NC_001802 634 635 5011 9387 13763 18139 22515 26891 31267 38287 NC_001802 635 636 5012 9388 13764 18140 22516 26892 31268 38288 NC_001802 636 637 5013 9389 13765 18141 22517 26893 31269 38289 NC_001802 637 638 5014 9390 13766 18142 22518 26894 31270 35428 NC_001798 638 639 5015 9391 13767 18143 22519 26895 31271 35429 NC_001798 639 640 5016 9392 13768 18144 22520 26896 31272 35430 NC_001798 640 641 5017 9393 13769 18145 22521 26897 31273 35431 NC_001798 641 642 5018 9394 13770 18146 22522 26898 31274 35432 NC_001798 642 643 5019 9395 13771 18147 22523 26899 31275 35433 38290 NC_001798 643 644 5020 9396 13772 18148 22524 26900 31276 38291 NC_001798 644 645 5021 9397 13773 18149 22525 26901 31277 38292 NC_001798 645 646 5022 9398 13774 18150 22526 26902 31278 35434 38293 NC_001798 646 647 5023 9399 13775 18151 22527 26903 31279 35435 38294 NC_001798 647 648 5024 9400 13776 18152 22528 26904 31280 38295 NC_001798 648 649 5025 9401 13777 18153 22529 26905 31281 35436 38296 NC_001798 649 650 5026 9402 13778 18154 22530 26906 31282 35437 38297 NC_001798 650 651 5027 9403 13779 18155 22531 26907 31283 35438 NC_001798 651 652 5028 9404 13780 18156 22532 26908 31284 38298 NC_001798 652 653 5029 9405 13781 18157 22533 26909 31285 35439 38299 NC_001798 653 654 5030 9406 13782 18158 22534 26910 31286 38300 NC_001798 654 655 5031 9407 13783 18159 22535 26911 31287 38301 NC_001798 655 656 5032 9408 13784 18160 22536 26912 31288 35440 38302 NC_001798 656 657 5033 9409 13785 18161 22537 26913 31289 35441 38303 NC_001798 657 658 5034 9410 13786 18162 22538 26914 31290 35442 38304 NC_001798 658 659 5035 9411 13787 18163 22539 26915 31291 38305 NC_001798 659 660 5036 9412 13788 18164 22540 26916 31292 38306 NC_001798 660 661 5037 9413 13789 18165 22541 26917 31293 35443 38307 NC_001798 661 662 5038 9414 13790 18166 22542 26918 31294 35444 38308 NC_001798 662 663 5039 9415 13791 18167 22543 26919 31295 38309 NC_001798 663 664 5040 9416 13792 18168 22544 26920 31296 38310 NC_001798 664 665 5041 9417 13793 18169 22545 26921 31297 35445 NC_001798 665 666 5042 9418 13794 18170 22546 26922 31298 38311 NC_001798 666 667 5043 9419 13795 18171 22547 26923 31299 38312 NC_001798 667 668 5044 9420 13796 18172 22548 26924 31300 35446 NC_001798 668 669 5045 9421 13797 18173 22549 26925 31301 35447 NC_001798 669 670 5046 9422 13798 18174 22550 26926 31302 35448 38313 NC_001798 670 671 5047 9423 13799 18175 22551 26927 31303 38314 NC_001798 671 672 5048 9424 13800 18176 22552 26928 31304 38315 NC_001798 672 673 5049 9425 13801 18177 22553 26929 31305 38316 NC_001798 673 674 5050 9426 13802 18178 22554 26930 31306 35449 NC_001798 674 675 5051 9427 13803 18179 22555 26931 31307 35450 NC_001798 675 676 5052 9428 13804 18180 22556 26932 31308 38317 NC_001798 676 677 5053 9429 13805 18181 22557 26933 31309 35451 38318 NC_001798 677 678 5054 9430 13806 18182 22558 26934 31310 38319 NC_001798 678 679 5055 9431 13807 18183 22559 26935 31311 35452 38320 NC_001798 679 680 5056 9432 13808 18184 22560 26936 31312 35453 38321 NC_001798 680 681 5057 9433 13809 18185 22561 26937 31313 35454 NC_001798 681 682 5058 9434 13810 18186 22562 26938 31314 35455 38322 NC_001798 682 683 5059 9435 13811 18187 22563 26939 31315 35456 NC_001798 683 684 5060 9436 13812 18188 22564 26940 31316 35457 NC_001798 684 685 5061 9437 13813 18189 22565 26941 31317 38323 NC_001798 685 686 5062 9438 13814 18190 22566 26942 31318 35458 38324 NC_001798 686 687 5063 9439 13815 18191 22567 26943 31319 35459 38325 NC_001798 687 688 5064 9440 13816 18192 22568 26944 31320 38326 NC_001798 688 689 5065 9441 13817 18193 22569 26945 31321 35460 38327 NC_001798 689 690 5066 9442 13818 18194 22570 26946 31322 35461 NC_001798 690 691 5067 9443 13819 18195 22571 26947 31323 35462 38328 NC_001798 691 692 5068 9444 13820 18196 22572 26948 31324 38329 NC_001798 692 693 5069 9445 13821 18197 22573 26949 31325 35463 38330 NC_001798 693 694 5070 9446 13822 18198 22574 26950 31326 35464 38331 NC_001798 694 695 5071 9447 13823 18199 22575 26951 31327 35465 38332 NC_001798 695 696 5072 9448 13824 18200 22576 26952 31328 35466 38333 NC_001798 696 697 5073 9449 13825 18201 22577 26953 31329 35467 38334 NC_001798 697 698 5074 9450 13826 18202 22578 26954 31330 38335 NC_001798 698 699 5075 9451 13827 18203 22579 26955 31331 35468 38336 NC_001798 699 700 5076 9452 13828 18204 22580 26956 31332 35469 NC_001798 700 701 5077 9453 13829 18205 22581 26957 31333 35470 NC_001798 701 702 5078 9454 13830 18206 22582 26958 31334 38337 NC_001354 702 703 5079 9455 13831 18207 22583 26959 31335 38338 NC_001354 703 704 5080 9456 13832 18208 22584 26960 31336 35471 NC_001354 704 705 5081 9457 13833 18209 22585 26961 31337 38339 NC_001354 705 706 5082 9458 13834 18210 22586 26962 31338 35472 NC_001354 706 707 5083 9459 13835 18211 22587 26963 31339 35473 38340 NC_001354 707 708 5084 9460 13836 18212 22588 26964 31340 38341 NC_001354 708 709 5085 9461 13837 18213 22589 26965 31341 38342 NC_001354 709 710 5086 9462 13838 18214 22590 26966 31342 35474 NC_001354 710 711 5087 9463 13839 18215 22591 26967 31343 38343 NC_001354 711 712 5088 9464 13840 18216 22592 26968 31344 35475 38344 NC_001354 712 713 5089 9465 13841 18217 22593 26969 31345 35476 38345 NC_001354 713 714 5090 9466 13842 18218 22594 26970 31346 38346 NC_001354 714 715 5091 9467 13843 18219 22595 26971 31347 35477 NC_001354 715 716 5092 9468 13844 18220 22596 26972 31348 35478 NC_001354 716 717 5093 9469 13845 18221 22597 26973 31349 35479 NC_001354 717 718 5094 9470 13846 18222 22598 26974 31350 35480 38347 NC_001354 718 719 5095 9471 13847 18223 22599 26975 31351 38348 NC_001354 719 720 5096 9472 13848 18224 22600 26976 31352 35481 NC_001354 720 721 5097 9473 13849 18225 22601 26977 31353 35482 NC_001354 721 722 5098 9474 13850 18226 22602 26978 31354 38349 NC_022892 722 723 5099 9475 13851 18227 22603 26979 31355 38350 NC_022892 723 724 5100 9476 13852 18228 22604 26980 31356 35483 NC_022892 724 725 5101 9477 13853 18229 22605 26981 31357 35484 NC_022892 725 726 5102 9478 13854 18230 22606 26982 31358 38351 NC_022892 726 727 5103 9479 13855 18231 22607 26983 31359 38352 NC_022892 727 728 5104 9480 13856 18232 22608 26984 31360 35485 NC_022892 728 729 5105 9481 13857 18233 22609 26985 31361 35486 NC_022892 729 730 5106 9482 13858 18234 22610 26986 31362 38353 NC_039086 730 731 5107 9483 13859 18235 22611 26987 31363 38354 NC_039086 731 732 5108 9484 13860 18236 22612 26988 31364 35487 NC_039086 732 733 5109 9485 13861 18237 22613 26989 31365 38355 NC_039086 733 734 5110 9486 13862 18238 22614 26990 31366 38356 NC_039086 734 735 5111 9487 13863 18239 22615 26991 31367 38357 NC_039086 735 736 5112 9488 13864 18240 22616 26992 31368 38358 NC_039086 736 737 5113 9489 13865 18241 22617 26993 31369 38359 NC_039086 737 738 5114 9490 13866 18242 22618 26994 31370 35488 NC_039086 738 739 5115 9491 13867 18243 22619 26995 31371 35489 NC_039086 739 740 5116 9492 13868 18244 22620 26996 31372 35490 NC_039086 740 741 5117 9493 13869 18245 22621 26997 31373 35491 NC_039086 741 742 5118 9494 13870 18246 22622 26998 31374 35492 38360 NC_039086 742 743 5119 9495 13871 18247 22623 26999 31375 35493 38361 NC_039086 743 744 5120 9496 13872 18248 22624 27000 31376 38362 NC_039086 744 745 5121 9497 13873 18249 22625 27001 31377 35494 NC_039086 745 746 5122 9498 13874 18250 22626 27002 31378 35495 NC_039086 746 747 5123 9499 13875 18251 22627 27003 31379 38363 NC_039086 747 748 5124 9500 13876 18252 22628 27004 31380 38364 NC_039086 748 749 5125 9501 13877 18253 22629 27005 31381 38365 NC_006307 749 750 5126 9502 13878 18254 22630 27006 31382 35496 NC_006307 750 751 5127 9503 13879 18255 22631 27007 31383 35497 NC_006307 751 752 5128 9504 13880 18256 22632 27008 31384 35498 NC_006307 752 753 5129 9505 13881 18257 22633 27009 31385 38366 NC_010329 753 754 5130 9506 13882 18258 22634 27010 31386 35499 NC_010329 754 755 5131 9507 13883 18259 22635 27011 31387 38367 NC_010329 755 756 5132 9508 13884 18260 22636 27012 31388 35500 NC_010329 756 757 5133 9509 13885 18261 22637 27013 31389 35501 NC_010329 757 758 5134 9510 13886 18262 22638 27014 31390 35502 NC_010329 758 759 5135 9511 13887 18263 22639 27015 31391 38368 NC_010329 759 760 5136 9512 13888 18264 22640 27016 31392 35503 38369 NC_010329 760 761 5137 9513 13889 18265 22641 27017 31393 35504 NC_010329 761 762 5138 9514 13890 18266 22642 27018 31394 35505 NC_010329 762 763 5139 9515 13891 18267 22643 27019 31395 35506 NC_010329 763 764 5140 9516 13892 18268 22644 27020 31396 35507 NC_010329 764 765 5141 9517 13893 18269 22645 27021 31397 35508 NC_010329 765 766 5142 9518 13894 18270 22646 27022 31398 35509 NC_010329 766 767 5143 9519 13895 18271 22647 27023 31399 38370 NC_010329 767 768 5144 9520 13896 18272 22648 27024 31400 35510 NC_010329 768 769 5145 9521 13897 18273 22649 27025 31401 35511 NC_022095 769 770 5146 9522 13898 18274 22650 27026 31402 35512 NC_022095 770 771 5147 9523 13899 18275 22651 27027 31403 35513 NC_022095 771 772 5148 9524 13900 18276 22652 27028 31404 35514 NC_022095 772 773 5149 9525 13901 18277 22653 27029 31405 35515 NC_022095 773 774 5150 9526 13902 18278 22654 27030 31406 38371 NC_022095 774 775 5151 9527 13903 18279 22655 27031 31407 35516 38372 NC_022095 775 776 5152 9528 13904 18280 22656 27032 31408 35517 NC_022095 776 777 5153 9529 13905 18281 22657 27033 31409 35518 NC_022095 777 778 5154 9530 13906 18282 22658 27034 31410 35519 NC_022095 778 779 5155 9531 13907 18283 22659 27035 31411 38373 NC_022095 779 780 5156 9532 13908 18284 22660 27036 31412 38374 NC_006306 780 781 5157 9533 13909 18285 22661 27037 31413 35520 NC_006306 781 782 5158 9534 13910 18286 22662 27038 31414 38375 NC_006306 782 783 5159 9535 13911 18287 22663 27039 31415 35521 NC_038312 783 784 5160 9536 13912 18288 22664 27040 31416 35522 NC_038312 784 785 5161 9537 13913 18289 22665 27041 31417 38376 NC_038312 785 786 5162 9538 13914 18290 22666 27042 31418 35523 NC_038312 786 787 5163 9539 13915 18291 22667 27043 31419 35524 NC_038312 787 788 5164 9540 13916 18292 22668 27044 31420 38377 NC_038312 788 789 5165 9541 13917 18293 22669 27045 31421 35525 NC_038312 789 790 5166 9542 13918 18294 22670 27046 31422 35526 NC_038312 790 791 5167 9543 13919 18295 22671 27047 31423 35527 NC_038312 791 792 5168 9544 13920 18296 22672 27048 31424 35528 NC_038312 792 793 5169 9545 13921 18297 22673 27049 31425 38378 NC_038312 793 794 5170 9546 13922 18298 22674 27050 31426 35529 38379 NC_038312 794 795 5171 9547 13923 18299 22675 27051 31427 35530 NC_038312 795 796 5172 9548 13924 18300 22676 27052 31428 35531 NC_038312 796 797 5173 9549 13925 18301 22677 27053 31429 35532 NC_038312 797 798 5174 9550 13926 18302 22678 27054 31430 38380 NC_038312 798 799 5175 9551 13927 18303 22679 27055 31431 38381 NC_038312 799 800 5176 9552 13928 18304 22680 27056 31432 38382 NC_038312 800 801 5177 9553 13929 18305 22681 27057 31433 38383 NC_002022 801 802 5178 9554 13930 18306 22682 27058 31434 35533 NC_002022 802 803 5179 9555 13931 18307 22683 27059 31435 38384 NC_002022 803 804 5180 9556 13932 18308 22684 27060 31436 35534 38385 NC_002022 804 805 5181 9557 13933 18309 22685 27061 31437 35535 NC_002022 805 806 5182 9558 13934 18310 22686 27062 31438 38386 NC_026422 806 807 5183 9559 13935 18311 22687 27063 31439 35536 NC_026422 807 808 5184 9560 13936 18312 22688 27064 31440 38387 NC_026422 808 809 5185 9561 13937 18313 22689 27065 31441 35537 38388 NC_026422 809 810 5186 9562 13938 18314 22690 27066 31442 35538 NC_026422 810 811 5187 9563 13939 18315 22691 27067 31443 38389 NC_026422 811 812 5188 9564 13940 18316 22692 27068 31444 35539 NC_026422 812 813 5189 9565 13941 18317 22693 27069 31445 35540 NC_026422 813 814 5190 9566 13942 18318 22694 27070 31446 35541 NC_013035 814 815 5191 9567 13943 18319 22695 27071 31447 35542 NC_013035 815 816 5192 9568 13944 18320 22696 27072 31448 38390 NC_013035 816 817 5193 9569 13945 18321 22697 27073 31449 38391 NC_013035 817 818 5194 9570 13946 18322 22698 27074 31450 35543 38392 NC_013035 818 819 5195 9571 13947 18323 22699 27075 31451 35544 NC_013035 819 820 5196 9572 13948 18324 22700 27076 31452 38393 NC_013035 820 821 5197 9573 13949 18325 22701 27077 31453 35545 NC_013035 821 822 5198 9574 13950 18326 22702 27078 31454 38394 NC_013035 822 823 5199 9575 13951 18327 22703 27079 31455 35546 NC_013035 823 824 5200 9576 13952 18328 22704 27080 31456 35547 NC_009827 824 825 5201 9577 13953 18329 22705 27081 31457 35548 38395 NC_009827 825 826 5202 9578 13954 18330 22706 27082 31458 35549 38396 NC_009827 826 827 5203 9579 13955 18331 22707 27083 31459 38397 NC_009827 827 828 5204 9580 13956 18332 22708 27084 31460 38398 NC_009827 828 829 5205 9581 13957 18333 22709 27085 31461 35550 38399 NC_009827 829 830 5206 9582 13958 18334 22710 27086 31462 38400 NC_009827 830 831 5207 9583 13959 18335 22711 27087 31463 35551 NC_009827 831 832 5208 9584 13960 18336 22712 27088 31464 35552 38401 NC_009827 832 833 5209 9585 13961 18337 22713 27089 31465 38402 NC_009827 833 834 5210 9586 13962 18338 22714 27090 31466 35553 NC_009827 834 835 5211 9587 13963 18339 22715 27091 31467 35554 38403 NC_009827 835 836 5212 9588 13964 18340 22716 27092 31468 35555 38404 NC_009827 836 837 5213 9589 13965 18341 22717 27093 31469 38405 NC_009827 837 838 5214 9590 13966 18342 22718 27094 31470 35556 NC_009827 838 839 5215 9591 13967 18343 22719 27095 31471 35557 NC_009827 839 840 5216 9592 13968 18344 22720 27096 31472 38406 NC_009827 840 841 5217 9593 13969 18345 22721 27097 31473 38407 NC_009827 841 842 5218 9594 13970 18346 22722 27098 31474 38408 NC_009827 842 843 5219 9595 13971 18347 22723 27099 31475 35558 38409 NC_009827 843 844 5220 9596 13972 18348 22724 27100 31476 35559 38410 NC_009827 844 845 5221 9597 13973 18349 22725 27101 31477 38411 NC_009827 845 846 5222 9598 13974 18350 22726 27102 31478 35560 NC_009827 846 847 5223 9599 13975 18351 22727 27103 31479 35561 NC_009827 847 848 5224 9600 13976 18352 22728 27104 31480 35562 NC_009827 848 849 5225 9601 13977 18353 22729 27105 31481 35563 NC_009827 849 850 5226 9602 13978 18354 22730 27106 31482 38412 NC_006311 850 851 5227 9603 13979 18355 22731 27107 31483 35564 NC_006311 851 852 5228 9604 13980 18356 22732 27108 31484 35565 NC_006311 852 853 5229 9605 13981 18357 22733 27109 31485 35566 NC_006311 853 854 5230 9606 13982 18358 22734 27110 31486 38413 NC_006311 854 855 5231 9607 13983 18359 22735 27111 31487 38414 NC_006311 855 856 5232 9608 13984 18360 22736 27112 31488 35567 NC_027528 856 857 5233 9609 13985 18361 22737 27113 31489 38415 NC_027528 857 858 5234 9610 13986 18362 22738 27114 31490 38416 NC_027528 858 859 5235 9611 13987 18363 22739 27115 31491 38417 NC_027528 859 860 5236 9612 13988 18364 22740 27116 31492 38418 NC_027528 860 861 5237 9613 13989 18365 22741 27117 31493 35568 NC_027528 861 862 5238 9614 13990 18366 22742 27118 31494 35569 NC_027528 862 863 5239 9615 13991 18367 22743 27119 31495 35570 NC_027528 863 864 5240 9616 13992 18368 22744 27120 31496 35571 NC_027528 864 865 5241 9617 13993 18369 22745 27121 31497 38419 NC_027528 865 866 5242 9618 13994 18370 22746 27122 31498 35572 38420 NC_027528 866 867 5243 9619 13995 18371 22747 27123 31499 35573 NC_027528 867 868 5244 9620 13996 18372 22748 27124 31500 35574 NC_027528 868 869 5245 9621 13997 18373 22749 27125 31501 38421 NC_027528 869 870 5246 9622 13998 18374 22750 27126 31502 38422 NC_027528 870 871 5247 9623 13999 18375 22751 27127 31503 35575 NC_007367 871 872 5248 9624 14000 18376 22752 27128 31504 35576 38423 NC_007367 872 873 5249 9625 14001 18377 22753 27129 31505 35577 NC_001526 873 874 5250 9626 14002 18378 22754 27130 31506 35578 NC_001526 874 875 5251 9627 14003 18379 22755 27131 31507 38424 NC_001526 875 876 5252 9628 14004 18380 22756 27132 31508 35579 NC_001526 876 877 5253 9629 14005 18381 22757 27133 31509 35580 NC_001526 877 878 5254 9630 14006 18382 22758 27134 31510 38425 NC_001526 878 879 5255 9631 14007 18383 22759 27135 31511 35581 NC_001526 879 880 5256 9632 14008 18384 22760 27136 31512 38426 NC_001526 880 881 5257 9633 14009 18385 22761 27137 31513 35582 NC_001526 881 882 5258 9634 14010 18386 22762 27138 31514 35583 38427 NC_001526 882 883 5259 9635 14011 18387 22763 27139 31515 38428 NC_001526 883 884 5260 9636 14012 18388 22764 27140 31516 38429 NC_001526 884 885 5261 9637 14013 18389 22765 27141 31517 38430 NC_001526 885 886 5262 9638 14014 18390 22766 27142 31518 38431 NC_001526 886 887 5263 9639 14015 18391 22767 27143 31519 35584 38432 NC_026424 887 888 5264 9640 14016 18392 22768 27144 31520 35585 38433 NC_026424 888 889 5265 9641 14017 18393 22769 27145 31521 35586 NC_026424 889 890 5266 9642 14018 18394 22770 27146 31522 38434 NC_026424 890 891 5267 9643 14019 18395 22771 27147 31523 35587 NC_026424 891 892 5268 9644 14020 18396 22772 27148 31524 38435 NC_026424 892 893 5269 9645 14021 18397 22773 27149 31525 38436 NC_026423 893 894 5270 9646 14022 18398 22774 27150 31526 35588 NC_026423 894 895 5271 9647 14023 18399 22775 27151 31527 35589 NC_026423 895 896 5272 9648 14024 18400 22776 27152 31528 35590 NC_026423 896 897 5273 9649 14025 18401 22777 27153 31529 38437 NC_026423 897 898 5274 9650 14026 18402 22778 27154 31530 35591 NC_026423 898 899 5275 9651 14027 18403 22779 27155 31531 35592 NC_001458 899 900 5276 9652 14028 18404 22780 27156 31532 35593 NC_001458 900 901 5277 9653 14029 18405 22781 27157 31533 35594 NC_001458 901 902 5278 9654 14030 18406 22782 27158 31534 35595 38438 NC_001458 902 903 5279 9655 14031 18407 22783 27159 31535 35596 38439 NC_001458 903 904 5280 9656 14032 18408 22784 27160 31536 35597 NC_001458 904 905 5281 9657 14033 18409 22785 27161 31537 35598 NC_001458 905 906 5282 9658 14034 18410 22786 27162 31538 38440 NC_001458 906 907 5283 9659 14035 18411 22787 27163 31539 35599 NC_001458 907 908 5284 9660 14036 18412 22788 27164 31540 38441 NC_001458 908 909 5285 9661 14037 18413 22789 27165 31541 35600 NC_001458 909 910 5286 9662 14038 18414 22790 27166 31542 35601 NC_001458 910 911 5287 9663 14039 18415 22791 27167 31543 38442 NC_001458 911 912 5288 9664 14040 18416 22792 27168 31544 38443 NC_001458 912 913 5289 9665 14041 18417 22793 27169 31545 38444 NC_001458 913 914 5290 9666 14042 18418 22794 27170 31546 35602 NC_001458 914 915 5291 9667 14043 18419 22795 27171 31547 35603 NC_001458 915 916 5292 9668 14044 18420 22796 27172 31548 38445 NC_001458 916 917 5293 9669 14045 18421 22797 27173 31549 35604 38446 NC_026436 917 918 5294 9670 14046 18422 22798 27174 31550 38447 NC_026436 918 919 5295 9671 14047 18423 22799 27175 31551 38448 NC_026436 919 920 5296 9672 14048 18424 22800 27176 31552 35605 NC_026436 920 921 5297 9673 14049 18425 22801 27177 31553 38449 NC_002018 921 922 5298 9674 14050 18426 22802 27178 31554 35606 38450 NC_002018 922 923 5299 9675 14051 18427 22803 27179 31555 35607 NC_002018 923 924 5300 9676 14052 18428 22804 27180 31556 38451 NC_002018 924 925 5301 9677 14053 18429 22805 27181 31557 35608 NC_007358 925 926 5302 9678 14054 18430 22806 27182 31558 38452 NC_007358 926 927 5303 9679 14055 18431 22807 27183 31559 35609 NC_007358 927 928 5304 9680 14056 18432 22808 27184 31560 38453 NC_007358 928 929 5305 9681 14057 18433 22809 27185 31561 35610 NC_007358 929 930 5306 9682 14058 18434 22810 27186 31562 35611 38454 NC_001357 930 931 5307 9683 14059 18435 22811 27187 31563 38455 NC_001357 931 932 5308 9684 14060 18436 22812 27188 31564 38456 NC_001357 932 933 5309 9685 14061 18437 22813 27189 31565 38457 NC_001357 933 934 5310 9686 14062 18438 22814 27190 31566 35612 38458 NC_001357 934 935 5311 9687 14063 18439 22815 27191 31567 38459 NC_001357 935 936 5312 9688 14064 18440 22816 27192 31568 35613 38460 NC_001357 936 937 5313 9689 14065 18441 22817 27193 31569 35614 NC_001357 937 938 5314 9690 14066 18442 22818 27194 31570 35615 NC_001357 938 939 5315 9691 14067 18443 22819 27195 31571 38461 NC_001357 939 940 5316 9692 14068 18444 22820 27196 31572 35616 NC_001357 940 941 5317 9693 14069 18445 22821 27197 31573 35617 NC_001357 941 942 5318 9694 14070 18446 22822 27198 31574 35618 NC_001357 942 943 5319 9695 14071 18447 22823 27199 31575 35619 NC_001357 943 944 5320 9696 14072 18448 22824 27200 31576 38462 NC_001357 944 945 5321 9697 14073 18449 22825 27201 31577 35620 NC_001357 945 946 5322 9698 14074 18450 22826 27202 31578 35621 NC_001357 946 947 5323 9699 14075 18451 22827 27203 31579 35622 NC_002021 947 948 5324 9700 14076 18452 22828 27204 31580 38463 NC_002021 948 949 5325 9701 14077 18453 22829 27205 31581 38464 NC_002021 949 950 5326 9702 14078 18454 22830 27206 31582 35623 NC_002021 950 951 5327 9703 14079 18455 22831 27207 31583 38465 NC_002021 951 952 5328 9704 14080 18456 22832 27208 31584 35624 NC_002021 952 953 5329 9705 14081 18457 22833 27209 31585 35625 38466 NC_001837 953 954 5330 9706 14082 18458 22834 27210 31586 35626 38467 NC_001837 954 955 5331 9707 14083 18459 22835 27211 31587 35627 NC_001837 955 956 5332 9708 14084 18460 22836 27212 31588 35628 38468 NC_001837 956 957 5333 9709 14085 18461 22837 27213 31589 38469 NC_001837 957 958 5334 9710 14086 18462 22838 27214 31590 35629 38470 NC_001837 958 959 5335 9711 14087 18463 22839 27215 31591 35630 NC_001837 959 960 5336 9712 14088 18464 22840 27216 31592 35631 38471 NC_001837 960 961 5337 9713 14089 18465 22841 27217 31593 35632 38472 NC_001837 961 962 5338 9714 14090 18466 22842 27218 31594 35633 38473 NC_001837 962 963 5339 9715 14091 18467 22843 27219 31595 38474 NC_001837 963 964 5340 9716 14092 18468 22844 27220 31596 38475 NC_001837 964 965 5341 9717 14093 18469 22845 27221 31597 35634 38476 NC_001837 965 966 5342 9718 14094 18470 22846 27222 31598 35635 NC_001837 966 967 5343 9719 14095 18471 22847 27223 31599 38477 NC_001837 967 968 5344 9720 14096 18472 22848 27224 31600 35636 38478 NC_001837 968 969 5345 9721 14097 18473 22849 27225 31601 35637 38479 NC_001837 969 970 5346 9722 14098 18474 22850 27226 31602 35638 38480 NC_001837 970 971 5347 9723 14099 18475 22851 27227 31603 38481 NC_001837 971 972 5348 9724 14100 18476 22852 27228 31604 38482 NC_001837 972 973 5349 9725 14101 18477 22853 27229 31605 38483 NC_001837 973 974 5350 9726 14102 18478 22854 27230 31606 38484 NC_001837 974 975 5351 9727 14103 18479 22855 27231 31607 35639 38485 NC_001837 975 976 5352 9728 14104 18480 22856 27232 31608 35640 NC_001837 976 977 5353 9729 14105 18481 22857 27233 31609 35641 38486 NC_001837 977 978 5354 9730 14106 18482 22858 27234 31610 38487 NC_001837 978 979 5355 9731 14107 18483 22859 27235 31611 35642 38488 NC_001837 979 980 5356 9732 14108 18484 22860 27236 31612 35643 NC_001531 980 981 5357 9733 14109 18485 22861 27237 31613 35644 NC_001531 981 982 5358 9734 14110 18486 22862 27238 31614 35645 NC_001531 982 983 5359 9735 14111 18487 22863 27239 31615 38489 NC_001531 983 984 5360 9736 14112 18488 22864 27240 31616 35646 NC_001531 984 985 5361 9737 14113 18489 22865 27241 31617 38490 NC_001531 985 986 5362 9738 14114 18490 22866 27242 31618 35647 38491 NC_001531 986 987 5363 9739 14115 18491 22867 27243 31619 35648 NC_001531 987 988 5364 9740 14116 18492 22868 27244 31620 38492 NC_001531 988 989 5365 9741 14117 18493 22869 27245 31621 35649 38493 NC_001531 989 990 5366 9742 14118 18494 22870 27246 31622 35650 38494 NC_001531 990 991 5367 9743 14119 18495 22871 27247 31623 38495 NC_001531 991 992 5368 9744 14120 18496 22872 27248 31624 35651 NC_001531 992 993 5369 9745 14121 18497 22873 27249 31625 38496 NC_001531 993 994 5370 9746 14122 18498 22874 27250 31626 38497 NC_001531 994 995 5371 9747 14123 18499 22875 27251 31627 38498 NC_001531 995 996 5372 9748 14124 18500 22876 27252 31628 38499 NC_001531 996 997 5373 9749 14125 18501 22877 27253 31629 35652 NC_001531 997 998 5374 9750 14126 18502 22878 27254 31630 35653 NC_004909 998 999 5375 9751 14127 18503 22879 27255 31631 35654 NC_004909 999 1000 5376 9752 14128 18504 22880 27256 31632 35655 38500 NC_004909 1000 1001 5377 9753 14129 18505 22881 27257 31633 35656 38501 NC_004909 1001 1002 5378 9754 14130 18506 22882 27258 31634 35657 NC_004909 1002 1003 5379 9755 14131 18507 22883 27259 31635 38502 NC_002208 1003 1004 5380 9756 14132 18508 22884 27260 31636 38503 NC_002208 1004 1005 5381 9757 14133 18509 22885 27261 31637 35658 NC_002208 1005 1006 5382 9758 14134 18510 22886 27262 31638 35659 NC_038523 1006 1007 5383 9759 14135 18511 22887 27263 31639 35660 NC_038523 1007 1008 5384 9760 14136 18512 22888 27264 31640 38504 NC_038523 1008 1009 5385 9761 14137 18513 22889 27265 31641 35661 NC_038523 1009 1010 5386 9762 14138 18514 22890 27266 31642 35662 NC_038523 1010 1011 5387 9763 14139 18515 22891 27267 31643 35663 38505 NC_038523 1011 1012 5388 9764 14140 18516 22892 27268 31644 35664 NC_038523 1012 1013 5389 9765 14141 18517 22893 27269 31645 38506 NC_038523 1013 1014 5390 9766 14142 18518 22894 27270 31646 35665 NC_038523 1014 1015 5391 9767 14143 18519 22895 27271 31647 38507 NC_038523 1015 1016 5392 9768 14144 18520 22896 27272 31648 35666 NC_038523 1016 1017 5393 9769 14145 18521 22897 27273 31649 38508 NC_038523 1017 1018 5394 9770 14146 18522 22898 27274 31650 35667 NC_038523 1018 1019 5395 9771 14147 18523 22899 27275 31651 38509 NC_038523 1019 1020 5396 9772 14148 18524 22900 27276 31652 35668 NC_038523 1020 1021 5397 9773 14149 18525 22901 27277 31653 35669 NC_038523 1021 1022 5398 9774 14150 18526 22902 27278 31654 35670 NC_007372 1022 1023 5399 9775 14151 18527 22903 27279 31655 35671 38510 NC_007372 1023 1024 5400 9776 14152 18528 22904 27280 31656 38511 NC_007372 1024 1025 5401 9777 14153 18529 22905 27281 31657 35672 NC_007372 1025 1026 5402 9778 14154 18530 22906 27282 31658 35673 NC_007372 1026 1027 5403 9779 14155 18531 22907 27283 31659 35674 NC_007372 1027 1028 5404 9780 14156 18532 22908 27284 31660 38512 NC_007372 1028 1029 5405 9781 14157 18533 22909 27285 31661 35675 NC_007372 1029 1030 5406 9782 14158 18534 22910 27286 31662 35676 NC_007372 1030 1031 5407 9783 14159 18535 22911 27287 31663 38513 NC_001691 1031 1032 5408 9784 14160 18536 22912 27288 31664 38514 NC_001691 1032 1033 5409 9785 14161 18537 22913 27289 31665 35677 38515 NC_001691 1033 1034 5410 9786 14162 18538 22914 27290 31666 35678 NC_001691 1034 1035 5411 9787 14163 18539 22915 27291 31667 35679 NC_001691 1035 1036 5412 9788 14164 18540 22916 27292 31668 35680 NC_001691 1036 1037 5413 9789 14165 18541 22917 27293 31669 38516 NC_001691 1037 1038 5414 9790 14166 18542 22918 27294 31670 35681 NC_001691 1038 1039 5415 9791 14167 18543 22919 27295 31671 35682 NC_001691 1039 1040 5416 9792 14168 18544 22920 27296 31672 38517 NC_001691 1040 1041 5417 9793 14169 18545 22921 27297 31673 35683 NC_001691 1041 1042 5418 9794 14170 18546 22922 27298 31674 38518 NC_001691 1042 1043 5419 9795 14171 18547 22923 27299 31675 35684 NC_012485 1043 1044 5420 9796 14172 18548 22924 27300 31676 38519 NC_012485 1044 1045 5421 9797 14173 18549 22925 27301 31677 35685 NC_012485 1045 1046 5422 9798 14174 18550 22926 27302 31678 35686 38520 NC_012485 1046 1047 5423 9799 14175 18551 22927 27303 31679 35687 NC_012485 1047 1048 5424 9800 14176 18552 22928 27304 31680 38521 NC_012485 1048 1049 5425 9801 14177 18553 22929 27305 31681 35688 NC_012485 1049 1050 5426 9802 14178 18554 22930 27306 31682 38522 NC_012485 1050 1051 5427 9803 14179 18555 22931 27307 31683 38523 NC_012485 1051 1052 5428 9804 14180 18556 22932 27308 31684 35689 38524 NC_012485 1052 1053 5429 9805 14181 18557 22933 27309 31685 35690 NC_012485 1053 1054 5430 9806 14182 18558 22934 27310 31686 35691 NC_014185 1054 1055 5431 9807 14183 18559 22935 27311 31687 35692 NC_014185 1055 1056 5432 9808 14184 18560 22936 27312 31688 35693 NC_014185 1056 1057 5433 9809 14185 18561 22937 27313 31689 35694 NC_014185 1057 1058 5434 9810 14186 18562 22938 27314 31690 35695 NC_014185 1058 1059 5435 9811 14187 18563 22939 27315 31691 35696 NC_014185 1059 1060 5436 9812 14188 18564 22940 27316 31692 35697 NC_014185 1060 1061 5437 9813 14189 18565 22941 27317 31693 35698 NC_014185 1061 1062 5438 9814 14190 18566 22942 27318 31694 38525 NC_014185 1062 1063 5439 9815 14191 18567 22943 27319 31695 35699 NC_014185 1063 1064 5440 9816 14192 18568 22944 27320 31696 38526 NC_014185 1064 1065 5441 9817 14193 18569 22945 27321 31697 35700 NC_014185 1065 1066 5442 9818 14194 18570 22946 27322 31698 38527 NC_014185 1066 1067 5443 9819 14195 18571 22947 27323 31699 35701 NC_014185 1067 1068 5444 9820 14196 18572 22948 27324 31700 38528 NC_014185 1068 1069 5445 9821 14197 18573 22949 27325 31701 38529 NC_014185 1069 1070 5446 9822 14198 18574 22950 27326 31702 35702 NC_001806 1070 1071 5447 9823 14199 18575 22951 27327 31703 35703 38530 NC_001806 1071 1072 5448 9824 14200 18576 22952 27328 31704 38531 NC_001806 1072 1073 5449 9825 14201 18577 22953 27329 31705 35704 38532 NC_001806 1073 1074 5450 9826 14202 18578 22954 27330 31706 35705 38533 NC_001806 1074 1075 5451 9827 14203 18579 22955 27331 31707 35706 NC_001806 1075 1076 5452 9828 14204 18580 22956 27332 31708 35707 NC_001806 1076 1077 5453 9829 14205 18581 22957 27333 31709 35708 38534 NC_001806 1077 1078 5454 9830 14206 18582 22958 27334 31710 35709 NC_001806 1078 1079 5455 9831 14207 18583 22959 27335 31711 35710 38535 NC_001806 1079 1080 5456 9832 14208 18584 22960 27336 31712 38536 NC_001806 1080 1081 5457 9833 14209 18585 22961 27337 31713 35711 NC_001806 1081 1082 5458 9834 14210 18586 22962 27338 31714 35712 38537 NC_001806 1082 1083 5459 9835 14211 18587 22963 27339 31715 35713 38538 NC_001806 1083 1084 5460 9836 14212 18588 22964 27340 31716 35714 NC_001806 1084 1085 5461 9837 14213 18589 22965 27341 31717 35715 38539 NC_001806 1085 1086 5462 9838 14214 18590 22966 27342 31718 38540 NC_001806 1086 1087 5463 9839 14215 18591 22967 27343 31719 38541 NC_001806 1087 1088 5464 9840 14216 18592 22968 27344 31720 35716 38542 NC_001806 1088 1089 5465 9841 14217 18593 22969 27345 31721 35717 NC_001806 1089 1090 5466 9842 14218 18594 22970 27346 31722 38543 NC_001806 1090 1091 5467 9843 14219 18595 22971 27347 31723 35718 38544 NC_001806 1091 1092 5468 9844 14220 18596 22972 27348 31724 35719 NC_001806 1092 1093 5469 9845 14221 18597 22973 27349 31725 38545 NC_001806 1093 1094 5470 9846 14222 18598 22974 27350 31726 35720 NC_001806 1094 1095 5471 9847 14223 18599 22975 27351 31727 35721 NC_001806 1095 1096 5472 9848 14224 18600 22976 27352 31728 35722 38546 NC_001806 1096 1097 5473 9849 14225 18601 22977 27353 31729 38547 NC_001806 1097 1098 5474 9850 14226 18602 22978 27354 31730 35723 38548 NC_001806 1098 1099 5475 9851 14227 18603 22979 27355 31731 35724 38549 NC_001806 1099 1100 5476 9852 14228 18604 22980 27356 31732 38550 NC_001806 1100 1101 5477 9853 14229 18605 22981 27357 31733 35725 38551 NC_001806 1101 1102 5478 9854 14230 18606 22982 27358 31734 35726 NC_001806 1102 1103 5479 9855 14231 18607 22983 27359 31735 38552 NC_001806 1103 1104 5480 9856 14232 18608 22984 27360 31736 35727 38553 NC_001806 1104 1105 5481 9857 14233 18609 22985 27361 31737 38554 NC_001806 1105 1106 5482 9858 14234 18610 22986 27362 31738 35728 NC_001806 1106 1107 5483 9859 14235 18611 22987 27363 31739 35729 NC_001806 1107 1108 5484 9860 14236 18612 22988 27364 31740 35730 NC_001806 1108 1109 5485 9861 14237 18613 22989 27365 31741 35731 38555 NC_001806 1109 1110 5486 9862 14238 18614 22990 27366 31742 35732 NC_001806 1110 1111 5487 9863 14239 18615 22991 27367 31743 35733 NC_001806 1111 1112 5488 9864 14240 18616 22992 27368 31744 35734 38556 NC_001806 1112 1113 5489 9865 14241 18617 22993 27369 31745 35735 38557 NC_001806 1113 1114 5490 9866 14242 18618 22994 27370 31746 35736 NC_001806 1114 1115 5491 9867 14243 18619 22995 27371 31747 38558 NC_001806 1115 1116 5492 9868 14244 18620 22996 27372 31748 38559 NC_001806 1116 1117 5493 9869 14245 18621 22997 27373 31749 35737 NC_001806 1117 1118 5494 9870 14246 18622 22998 27374 31750 35738 38560 NC_001806 1118 1119 5495 9871 14247 18623 22999 27375 31751 35739 38561 NC_001806 1119 1120 5496 9872 14248 18624 23000 27376 31752 35740 NC_001806 1120 1121 5497 9873 14249 18625 23001 27377 31753 35741 NC_001806 1121 1122 5498 9874 14250 18626 23002 27378 31754 35742 NC_001806 1122 1123 5499 9875 14251 18627 23003 27379 31755 35743 NC_001806 1123 1124 5500 9876 14252 18628 23004 27380 31756 35744 38562 NC_001806 1124 1125 5501 9877 14253 18629 23005 27381 31757 38563 NC_001806 1125 1126 5502 9878 14254 18630 23006 27382 31758 38564 NC_001806 1126 1127 5503 9879 14255 18631 23007 27383 31759 35745 NC_001806 1127 1128 5504 9880 14256 18632 23008 27384 31760 35746 38565 NC_001806 1128 1129 5505 9881 14257 18633 23009 27385 31761 38566 NC_001806 1129 1130 5506 9882 14258 18634 23010 27386 31762 35747 NC_001806 1130 1131 5507 9883 14259 18635 23011 27387 31763 35748 NC_001806 1131 1132 5508 9884 14260 18636 23012 27388 31764 35749 NC_001806 1132 1133 5509 9885 14261 18637 23013 27389 31765 35750 NC_001806 1133 1134 5510 9886 14262 18638 23014 27390 31766 35751 38567 NC_001806 1134 1135 5511 9887 14263 18639 23015 27391 31767 35752 NC_001806 1135 1136 5512 9888 14264 18640 23016 27392 31768 35753 NC_001806 1136 1137 5513 9889 14265 18641 23017 27393 31769 35754 NC_001806 1137 1138 5514 9890 14266 18642 23018 27394 31770 35755 38568 NC_001806 1138 1139 5515 9891 14267 18643 23019 27395 31771 38569 NC_001806 1139 1140 5516 9892 14268 18644 23020 27396 31772 35756 NC_001806 1140 1141 5517 9893 14269 18645 23021 27397 31773 35757 NC_001806 1141 1142 5518 9894 14270 18646 23022 27398 31774 35758 NC_001806 1142 1143 5519 9895 14271 18647 23023 27399 31775 35759 38570 NC_001806 1143 1144 5520 9896 14272 18648 23024 27400 31776 38571 NC_001806 1144 1145 5521 9897 14273 18649 23025 27401 31777 35760 38572 NC_001806 1145 1146 5522 9898 14274 18650 23026 27402 31778 35761 NC_001806 1146 1147 5523 9899 14275 18651 23027 27403 31779 35762 NC_001806 1147 1148 5524 9900 14276 18652 23028 27404 31780 38573 NC_001806 1148 1149 5525 9901 14277 18653 23029 27405 31781 38574 NC_001806 1149 1150 5526 9902 14278 18654 23030 27406 31782 35763 NC_001806 1150 1151 5527 9903 14279 18655 23031 27407 31783 38575 NC_001806 1151 1152 5528 9904 14280 18656 23032 27408 31784 35764 38576 NC_001806 1152 1153 5529 9905 14281 18657 23033 27409 31785 35765 38577 NC_001806 1153 1154 5530 9906 14282 18658 23034 27410 31786 35766 38578 NC_001806 1154 1155 5531 9907 14283 18659 23035 27411 31787 35767 38579 NC_001806 1155 1156 5532 9908 14284 18660 23036 27412 31788 35768 38580 NC_001806 1156 1157 5533 9909 14285 18661 23037 27413 31789 35769 38581 NC_001806 1157 1158 5534 9910 14286 18662 23038 27414 31790 35770 NC_001806 1158 1159 5535 9911 14287 18663 23039 27415 31791 35771 38582 NC_001806 1159 1160 5536 9912 14288 18664 23040 27416 31792 38583 NC_001806 1160 1161 5537 9913 14289 18665 23041 27417 31793 38584 NC_001806 1161 1162 5538 9914 14290 18666 23042 27418 31794 38585 NC_001806 1162 1163 5539 9915 14291 18667 23043 27419 31795 38586 NC_001806 1163 1164 5540 9916 14292 18668 23044 27420 31796 38587 NC_001806 1164 1165 5541 9917 14293 18669 23045 27421 31797 35772 38588 NC_001806 1165 1166 5542 9918 14294 18670 23046 27422 31798 35773 38589 NC_001806 1166 1167 5543 9919 14295 18671 23047 27423 31799 35774 NC_001806 1167 1168 5544 9920 14296 18672 23048 27424 31800 35775 NC_001806 1168 1169 5545 9921 14297 18673 23049 27425 31801 38590 NC_001806 1169 1170 5546 9922 14298 18674 23050 27426 31802 35776 38591 NC_001806 1170 1171 5547 9923 14299 18675 23051 27427 31803 35777 38592 NC_001806 1171 1172 5548 9924 14300 18676 23052 27428 31804 38593 NC_001806 1172 1173 5549 9925 14301 18677 23053 27429 31805 35778 38594 NC_001806 1173 1174 5550 9926 14302 18678 23054 27430 31806 38595 NC_001806 1174 1175 5551 9927 14303 18679 23055 27431 31807 35779 38596 NC_001806 1175 1176 5552 9928 14304 18680 23056 27432 31808 35780 38597 NC_001806 1176 1177 5553 9929 14305 18681 23057 27433 31809 35781 38598 NC_001806 1177 1178 5554 9930 14306 18682 23058 27434 31810 35782 NC_001806 1178 1179 5555 9931 14307 18683 23059 27435 31811 35783 38599 NC_007361 1179 1180 5556 9932 14308 18684 23060 27436 31812 38600 NC_007361 1180 1181 5557 9933 14309 18685 23061 27437 31813 38601 NC_007361 1181 1182 5558 9934 14310 18686 23062 27438 31814 35784 38602 NC_007361 1182 1183 5559 9935 14311 18687 23063 27439 31815 38603 NC_003977 1183 1184 5560 9936 14312 18688 23064 27440 31816 35785 38604 NC_003977 1184 1185 5561 9937 14313 18689 23065 27441 31817 35786 NC_003977 1185 1186 5562 9938 14314 18690 23066 27442 31818 35787 NC_003977 1186 1187 5563 9939 14315 18691 23067 27443 31819 35788 38605 NC_003977 1187 1188 5564 9940 14316 18692 23068 27444 31820 38606 NC_007373 1188 1189 5565 9941 14317 18693 23069 27445 31821 38607 NC_007373 1189 1190 5566 9942 14318 18694 23070 27446 31822 35789 NC_007373 1190 1191 5567 9943 14319 18695 23071 27447 31823 38608 NC_007373 1191 1192 5568 9944 14320 18696 23072 27448 31824 35790 NC_007373 1192 1193 5569 9945 14321 18697 23073 27449 31825 35791 NC_007373 1193 1194 5570 9946 14322 18698 23074 27450 31826 35792 38609 NC_007373 1194 1195 5571 9947 14323 18699 23075 27451 31827 35793 38610 NC_007373 1195 1196 5572 9948 14324 18700 23076 27452 31828 35794 NC_023891 1196 1197 5573 9949 14325 18701 23077 27453 31829 38611 NC_023891 1197 1198 5574 9950 14326 18702 23078 27454 31830 38612 NC_023891 1198 1199 5575 9951 14327 18703 23079 27455 31831 35795 NC_023891 1199 1200 5576 9952 14328 18704 23080 27456 31832 35796 38613 NC_023891 1200 1201 5577 9953 14329 18705 23081 27457 31833 35797 NC_023891 1201 1202 5578 9954 14330 18706 23082 27458 31834 38614 NC_023891 1202 1203 5579 9955 14331 18707 23083 27459 31835 35798 NC_023891 1203 1204 5580 9956 14332 18708 23084 27460 31836 38615 NC_023891 1204 1205 5581 9957 14333 18709 23085 27461 31837 35799 NC_023891 1205 1206 5582 9958 14334 18710 23086 27462 31838 35800 NC_023891 1206 1207 5583 9959 14335 18711 23087 27463 31839 38616 NC_023891 1207 1208 5584 9960 14336 18712 23088 27464 31840 35801 NC_023891 1208 1209 5585 9961 14337 18713 23089 27465 31841 35802 NC_023891 1209 1210 5586 9962 14338 18714 23090 27466 31842 38617 NC_023891 1210 1211 5587 9963 14339 18715 23091 27467 31843 35803 NC_023891 1211 1212 5588 9964 14340 18716 23092 27468 31844 38618 NC_023891 1212 1213 5589 9965 14341 18717 23093 27469 31845 35804 NC_001690 1213 1214 5590 9966 14342 18718 23094 27470 31846 38619 NC_001690 1214 1215 5591 9967 14343 18719 23095 27471 31847 35805 NC_001690 1215 1216 5592 9968 14344 18720 23096 27472 31848 35806 NC_001690 1216 1217 5593 9969 14345 18721 23097 27473 31849 38620 NC_001690 1217 1218 5594 9970 14346 18722 23098 27474 31850 35807 NC_001690 1218 1219 5595 9971 14347 18723 23099 27475 31851 38621 NC_001690 1219 1220 5596 9972 14348 18724 23100 27476 31852 38622 NC_001690 1220 1221 5597 9973 14349 18725 23101 27477 31853 35808 NC_001690 1221 1222 5598 9974 14350 18726 23102 27478 31854 38623 NC_001722 1222 1223 5599 9975 14351 18727 23103 27479 31855 38624 NC_001722 1223 1224 5600 9976 14352 18728 23104 27480 31856 35809 38625 NC_001722 1224 1225 5601 9977 14353 18729 23105 27481 31857 38626 NC_001722 1225 1226 5602 9978 14354 18730 23106 27482 31858 35810 NC_001722 1226 1227 5603 9979 14355 18731 23107 27483 31859 38627 NC_001722 1227 1228 5604 9980 14356 18732 23108 27484 31860 38628 NC_001722 1228 1229 5605 9981 14357 18733 23109 27485 31861 35811 38629 NC_001722 1229 1230 5606 9982 14358 18734 23110 27486 31862 35812 NC_001722 1230 1231 5607 9983 14359 18735 23111 27487 31863 35813 38630 NC_001722 1231 1232 5608 9984 14360 18736 23112 27488 31864 35814 NC_001722 1232 1233 5609 9985 14361 18737 23113 27489 31865 35815 NC_001722 1233 1234 5610 9986 14362 18738 23114 27490 31866 35816 NC_001722 1234 1235 5611 9987 14363 18739 23115 27491 31867 35817 NC_001722 1235 1236 5612 9988 14364 18740 23116 27492 31868 35818 NC_001722 1236 1237 5613 9989 14365 18741 23117 27493 31869 35819 38631 NC_001722 1237 1238 5614 9990 14366 18742 23118 27494 31870 35820 NC_001722 1238 1239 5615 9991 14367 18743 23119 27495 31871 38632 NC_001722 1239 1240 5616 9992 14368 18744 23120 27496 31872 35821 38633 NC_001722 1240 1241 5617 9993 14369 18745 23121 27497 31873 35822 NC_001722 1241 1242 5618 9994 14370 18746 23122 27498 31874 35823 38634 NC_001722 1242 1243 5619 9995 14371 18747 23123 27499 31875 38635 NC_001722 1243 1244 5620 9996 14372 18748 23124 27500 31876 38636 NC_001722 1244 1245 5621 9997 14373 18749 23125 27501 31877 35824 38637 NC_001722 1245 1246 5622 9998 14374 18750 23126 27502 31878 38638 NC_001722 1246 1247 5623 9999 14375 18751 23127 27503 31879 35825 38639 NC_001722 1247 1248 5624 10000 14376 18752 23128 27504 31880 35826 NC_001722 1248 1249 5625 10001 14377 18753 23129 27505 31881 38640 NC_001722 1249 1250 5626 10002 14378 18754 23130 27506 31882 38641 NC_002207 1250 1251 5627 10003 14379 18755 23131 27507 31883 38642 NC_002207 1251 1252 5628 10004 14380 18756 23132 27508 31884 35827 NC_002207 1252 1253 5629 10005 14381 18757 23133 27509 31885 35828 NC_002207 1253 1254 5630 10006 14382 18758 23134 27510 31886 35829 38643 NC_002207 1254 1255 5631 10007 14383 18759 23135 27511 31887 35830 38644 NC_002207 1255 1256 5632 10008 14384 18760 23136 27512 31888 35831 NC_002207 1256 1257 5633 10009 14385 18761 23137 27513 31889 35832 NC_007363 1257 1258 5634 10010 14386 18762 23138 27514 31890 35833 NC_007363 1258 1259 5635 10011 14387 18763 23139 27515 31891 38645 NC_007363 1259 1260 5636 10012 14388 18764 23140 27516 31892 35834 NC_038522 1260 1261 5637 10013 14389 18765 23141 27517 31893 35835 NC_038522 1261 1262 5638 10014 14390 18766 23142 27518 31894 35836 NC_038522 1262 1263 5639 10015 14391 18767 23143 27519 31895 38646 NC_038522 1263 1264 5640 10016 14392 18768 23144 27520 31896 35837 NC_038522 1264 1265 5641 10017 14393 18769 23145 27521 31897 35838 NC_038522 1265 1266 5642 10018 14394 18770 23146 27522 31898 35839 NC_038522 1266 1267 5643 10019 14395 18771 23147 27523 31899 35840 NC_038522 1267 1268 5644 10020 14396 18772 23148 27524 31900 38647 NC_038522 1268 1269 5645 10021 14397 18773 23149 27525 31901 38648 NC_038522 1269 1270 5646 10022 14398 18774 23150 27526 31902 38649 NC_038522 1270 1271 5647 10023 14399 18775 23151 27527 31903 35841 NC_038522 1271 1272 5648 10024 14400 18776 23152 27528 31904 38650 NC_038522 1272 1273 5649 10025 14401 18777 23153 27529 31905 38651 NC_038522 1273 1274 5650 10026 14402 18778 23154 27530 31906 35842 NC_038522 1274 1275 5651 10027 14403 18779 23155 27531 31907 35843 NC_021483 1275 1276 5652 10028 14404 18780 23156 27532 31908 35844 NC_021483 1276 1277 5653 10029 14405 18781 23157 27533 31909 35845 NC_021483 1277 1278 5654 10030 14406 18782 23158 27534 31910 35846 NC_021483 1278 1279 5655 10031 14407 18783 23159 27535 31911 35847 NC_021483 1279 1280 5656 10032 14408 18784 23160 27536 31912 35848 NC_021483 1280 1281 5657 10033 14409 18785 23161 27537 31913 35849 NC_021483 1281 1282 5658 10034 14410 18786 23162 27538 31914 35850 NC_021483 1282 1283 5659 10035 14411 18787 23163 27539 31915 35851 38652 NC_021483 1283 1284 5660 10036 14412 18788 23164 27540 31916 35852 38653 NC_021483 1284 1285 5661 10037 14413 18789 23165 27541 31917 35853 NC_021483 1285 1286 5662 10038 14414 18790 23166 27542 31918 38654 NC_021483 1286 1287 5663 10039 14415 18791 23167 27543 31919 35854 38655 NC_021483 1287 1288 5664 10040 14416 18792 23168 27544 31920 35855 NC_021483 1288 1289 5665 10041 14417 18793 23169 27545 31921 38656 NC_004910 1289 1290 5666 10042 14418 18794 23170 27546 31922 35856 NC_004910 1290 1291 5667 10043 14419 18795 23171 27547 31923 35857 NC_004910 1291 1292 5668 10044 14420 18796 23172 27548 31924 35858 NC_004910 1292 1293 5669 10045 14421 18797 23173 27549 31925 38657 NC_004910 1293 1294 5670 10046 14422 18798 23174 27550 31926 35859 38658 NC_004910 1294 1295 5671 10047 14423 18799 23175 27551 31927 38659 NC_004910 1295 1296 5672 10048 14424 18800 23176 27552 31928 35860 NC_004910 1296 1297 5673 10049 14425 18801 23177 27553 31929 38660 NC_004910 1297 1298 5674 10050 14426 18802 23178 27554 31930 35861 38661 NC_026425 1298 1299 5675 10051 14427 18803 23179 27555 31931 35862 NC_026425 1299 1300 5676 10052 14428 18804 23180 27556 31932 38662 NC_026425 1300 1301 5677 10053 14429 18805 23181 27557 31933 35863 NC_026425 1301 1302 5678 10054 14430 18806 23182 27558 31934 35864 NC_026425 1302 1303 5679 10055 14431 18807 23183 27559 31935 35865 38663 NC_026425 1303 1304 5680 10056 14432 18808 23184 27560 31936 38664 NC_001586 1304 1305 5681 10057 14433 18809 23185 27561 31937 38665 NC_001586 1305 1306 5682 10058 14434 18810 23186 27562 31938 35866 NC_001586 1306 1307 5683 10059 14435 18811 23187 27563 31939 35867 38666 NC_001586 1307 1308 5684 10060 14436 18812 23188 27564 31940 38667 NC_001586 1308 1309 5685 10061 14437 18813 23189 27565 31941 35868 NC_001586 1309 1310 5686 10062 14438 18814 23190 27566 31942 38668 NC_001586 1310 1311 5687 10063 14439 18815 23191 27567 31943 38669 NC_001586 1311 1312 5688 10064 14440 18816 23192 27568 31944 35869 NC_001586 1312 1313 5689 10065 14441 18817 23193 27569 31945 35870 38670 NC_001586 1313 1314 5690 10066 14442 18818 23194 27570 31946 38671 NC_001586 1314 1315 5691 10067 14443 18819 23195 27571 31947 35871 NC_001586 1315 1316 5692 10068 14444 18820 23196 27572 31948 38672 NC_001586 1316 1317 5693 10069 14445 18821 23197 27573 31949 38673 NC_001586 1317 1318 5694 10070 14446 18822 23198 27574 31950 38674 NC_001586 1318 1319 5695 10071 14447 18823 23199 27575 31951 35872 NC_001586 1319 1320 5696 10072 14448 18824 23200 27576 31952 38675 NC_001586 1320 1321 5697 10073 14449 18825 23201 27577 31953 38676 NC_017994 1321 1322 5698 10074 14450 18826 23202 27578 31954 35873 NC_017994 1322 1323 5699 10075 14451 18827 23203 27579 31955 35874 NC_017994 1323 1324 5700 10076 14452 18828 23204 27580 31956 35875 NC_017994 1324 1325 5701 10077 14453 18829 23205 27581 31957 35876 38677 NC_017994 1325 1326 5702 10078 14454 18830 23206 27582 31958 35877 38678 NC_017994 1326 1327 5703 10079 14455 18831 23207 27583 31959 38679 NC_017994 1327 1328 5704 10080 14456 18832 23208 27584 31960 35878 NC_017994 1328 1329 5705 10081 14457 18833 23209 27585 31961 38680 NC_017994 1329 1330 5706 10082 14458 18834 23210 27586 31962 35879 NC_017994 1330 1331 5707 10083 14459 18835 23211 27587 31963 38681 NC_017994 1331 1332 5708 10084 14460 18836 23212 27588 31964 38682 NC_004907 1332 1333 5709 10085 14461 18837 23213 27589 31965 38683 NC_004907 1333 1334 5710 10086 14462 18838 23214 27590 31966 35880 38684 NC_001796 1334 1335 5711 10087 14463 18839 23215 27591 31967 35881 NC_001796 1335 1336 5712 10088 14464 18840 23216 27592 31968 35882 NC_001796 1336 1337 5713 10089 14465 18841 23217 27593 31969 35883 38685 NC_001796 1337 1338 5714 10090 14466 18842 23218 27594 31970 35884 NC_001796 1338 1339 5715 10091 14467 18843 23219 27595 31971 35885 NC_001796 1339 1340 5716 10092 14468 18844 23220 27596 31972 35886 NC_001796 1340 1341 5717 10093 14469 18845 23221 27597 31973 35887 NC_001796 1341 1342 5718 10094 14470 18846 23222 27598 31974 38686 NC_001796 1342 1343 5719 10095 14471 18847 23223 27599 31975 38687 NC_001796 1343 1344 5720 10096 14472 18848 23224 27600 31976 35888 NC_001796 1344 1345 5721 10097 14473 18849 23225 27601 31977 35889 NC_001796 1345 1346 5722 10098 14474 18850 23226 27602 31978 38688 NC_001796 1346 1347 5723 10099 14475 18851 23227 27603 31979 35890 NC_001796 1347 1348 5724 10100 14476 18852 23228 27604 31980 38689 NC_001796 1348 1349 5725 10101 14477 18853 23229 27605 31981 38690 NC_001796 1349 1350 5726 10102 14478 18854 23230 27606 31982 35891 38691 NC_001796 1350 1351 5727 10103 14479 18855 23231 27607 31983 38692 NC_001796 1351 1352 5728 10104 14480 18856 23232 27608 31984 35892 NC_001796 1352 1353 5729 10105 14481 18857 23233 27609 31985 35893 NC_001796 1353 1354 5730 10106 14482 18858 23234 27610 31986 38693 NC_001796 1354 1355 5731 10107 14483 18859 23235 27611 31987 35894 NC_001796 1355 1356 5732 10108 14484 18860 23236 27612 31988 35895 NC_002645 1356 1357 5733 10109 14485 18861 23237 27613 31989 35896 38694 NC_002645 1357 1358 5734 10110 14486 18862 23238 27614 31990 38695 NC_002645 1358 1359 5735 10111 14487 18863 23239 27615 31991 35897 NC_002645 1359 1360 5736 10112 14488 18864 23240 27616 31992 35898 NC_002645 1360 1361 5737 10113 14489 18865 23241 27617 31993 38696 NC_002645 1361 1362 5738 10114 14490 18866 23242 27618 31994 35899 NC_002645 1362 1363 5739 10115 14491 18867 23243 27619 31995 35900 NC_002645 1363 1364 5740 10116 14492 18868 23244 27620 31996 35901 38697 NC_002645 1364 1365 5741 10117 14493 18869 23245 27621 31997 35902 NC_002645 1365 1366 5742 10118 14494 18870 23246 27622 31998 38698 NC_002645 1366 1367 5743 10119 14495 18871 23247 27623 31999 35903 NC_002645 1367 1368 5744 10120 14496 18872 23248 27624 32000 38699 NC_002645 1368 1369 5745 10121 14497 18873 23249 27625 32001 35904 NC_002645 1369 1370 5746 10122 14498 18874 23250 27626 32002 35905 NC_002645 1370 1371 5747 10123 14499 18875 23251 27627 32003 38700 NC_002645 1371 1372 5748 10124 14500 18876 23252 27628 32004 35906 NC_002645 1372 1373 5749 10125 14501 18877 23253 27629 32005 35907 NC_002645 1373 1374 5750 10126 14502 18878 23254 27630 32006 35908 38701 NC_002645 1374 1375 5751 10127 14503 18879 23255 27631 32007 35909 NC_002645 1375 1376 5752 10128 14504 18880 23256 27632 32008 35910 NC_002645 1376 1377 5753 10129 14505 18881 23257 27633 32009 35911 NC_002645 1377 1378 5754 10130 14506 18882 23258 27634 32010 35912 NC_002645 1378 1379 5755 10131 14507 18883 23259 27635 32011 35913 NC_002645 1379 1380 5756 10132 14508 18884 23260 27636 32012 35914 NC_002645 1380 1381 5757 10133 14509 18885 23261 27637 32013 35915 38702 NC_002645 1381 1382 5758 10134 14510 18886 23262 27638 32014 38703 NC_002645 1382 1383 5759 10135 14511 18887 23263 27639 32015 35916 38704 NC_002645 1383 1384 5760 10136 14512 18888 23264 27640 32016 38705 NC_002645 1384 1385 5761 10137 14513 18889 23265 27641 32017 38706 NC_002645 1385 1386 5762 10138 14514 18890 23266 27642 32018 35917 NC_002645 1386 1387 5763 10139 14515 18891 23267 27643 32019 35918 NC_002645 1387 1388 5764 10140 14516 18892 23268 27644 32020 35919 NC_002645 1388 1389 5765 10141 14517 18893 23269 27645 32021 38707 NC_002645 1389 1390 5766 10142 14518 18894 23270 27646 32022 35920 NC_002645 1390 1391 5767 10143 14519 18895 23271 27647 32023 35921 NC_002645 1391 1392 5768 10144 14520 18896 23272 27648 32024 35922 NC_002645 1392 1393 5769 10145 14521 18897 23273 27649 32025 35923 NC_002645 1393 1394 5770 10146 14522 18898 23274 27650 32026 35924 NC_002645 1394 1395 5771 10147 14523 18899 23275 27651 32027 35925 NC_002645 1395 1396 5772 10148 14524 18900 23276 27652 32028 35926 NC_002645 1396 1397 5773 10149 14525 18901 23277 27653 32029 35927 NC_002645 1397 1398 5774 10150 14526 18902 23278 27654 32030 35928 NC_002645 1398 1399 5775 10151 14527 18903 23279 27655 32031 35929 NC_002645 1399 1400 5776 10152 14528 18904 23280 27656 32032 35930 NC_002645 1400 1401 5777 10153 14529 18905 23281 27657 32033 38708 NC_002645 1401 1402 5778 10154 14530 18906 23282 27658 32034 35931 NC_002645 1402 1403 5779 10155 14531 18907 23283 27659 32035 35932 NC_002645 1403 1404 5780 10156 14532 18908 23284 27660 32036 38709 NC_002645 1404 1405 5781 10157 14533 18909 23285 27661 32037 35933 NC_002645 1405 1406 5782 10158 14534 18910 23286 27662 32038 35934 NC_002645 1406 1407 5783 10159 14535 18911 23287 27663 32039 35935 NC_002645 1407 1408 5784 10160 14536 18912 23288 27664 32040 35936 NC_002645 1408 1409 5785 10161 14537 18913 23289 27665 32041 35937 NC_002645 1409 1410 5786 10162 14538 18914 23290 27666 32042 35938 NC_002645 1410 1411 5787 10163 14539 18915 23291 27667 32043 35939 NC_002645 1411 1412 5788 10164 14540 18916 23292 27668 32044 35940 38710 NC_002645 1412 1413 5789 10165 14541 18917 23293 27669 32045 38711 NC_002645 1413 1414 5790 10166 14542 18918 23294 27670 32046 35941 NC_002645 1414 1415 5791 10167 14543 18919 23295 27671 32047 35942 NC_002645 1415 1416 5792 10168 14544 18920 23296 27672 32048 38712 NC_002645 1416 1417 5793 10169 14545 18921 23297 27673 32049 35943 NC_002645 1417 1418 5794 10170 14546 18922 23298 27674 32050 35944 NC_002645 1418 1419 5795 10171 14547 18923 23299 27675 32051 38713 NC_002645 1419 1420 5796 10172 14548 18924 23300 27676 32052 38714 NC_002645 1420 1421 5797 10173 14549 18925 23301 27677 32053 35945 NC_002645 1421 1422 5798 10174 14550 18926 23302 27678 32054 38715 NC_002645 1422 1423 5799 10175 14551 18927 23303 27679 32055 35946 38716 NC_002645 1423 1424 5800 10176 14552 18928 23304 27680 32056 35947 NC_002645 1424 1425 5801 10177 14553 18929 23305 27681 32057 38717 NC_002645 1425 1426 5802 10178 14554 18930 23306 27682 32058 35948 38718 NC_002645 1426 1427 5803 10179 14555 18931 23307 27683 32059 35949 NC_002645 1427 1428 5804 10180 14556 18932 23308 27684 32060 38719 NC_002645 1428 1429 5805 10181 14557 18933 23309 27685 32061 35950 38720 NC_002645 1429 1430 5806 10182 14558 18934 23310 27686 32062 38721 NC_002645 1430 1431 5807 10183 14559 18935 23311 27687 32063 35951 NC_002645 1431 1432 5808 10184 14560 18936 23312 27688 32064 38722 NC_002645 1432 1433 5809 10185 14561 18937 23313 27689 32065 38723 NC_002645 1433 1434 5810 10186 14562 18938 23314 27690 32066 35952 NC_002645 1434 1435 5811 10187 14563 18939 23315 27691 32067 35953 38724 NC_002645 1435 1436 5812 10188 14564 18940 23316 27692 32068 38725 NC_002645 1436 1437 5813 10189 14565 18941 23317 27693 32069 35954 NC_012213 1437 1438 5814 10190 14566 18942 23318 27694 32070 38726 NC_012213 1438 1439 5815 10191 14567 18943 23319 27695 32071 38727 NC_012213 1439 1440 5816 10192 14568 18944 23320 27696 32072 38728 NC_012213 1440 1441 5817 10193 14569 18945 23321 27697 32073 38729 NC_012213 1441 1442 5818 10194 14570 18946 23322 27698 32074 35955 NC_012213 1442 1443 5819 10195 14571 18947 23323 27699 32075 38730 NC_012213 1443 1444 5820 10196 14572 18948 23324 27700 32076 38731 NC_012213 1444 1445 5821 10197 14573 18949 23325 27701 32077 35956 38732 NC_012213 1445 1446 5822 10198 14574 18950 23326 27702 32078 35957 NC_012213 1446 1447 5823 10199 14575 18951 23327 27703 32079 38733 NC_012213 1447 1448 5824 10200 14576 18952 23328 27704 32080 35958 NC_012213 1448 1449 5825 10201 14577 18953 23329 27705 32081 38734 NC_012213 1449 1450 5826 10202 14578 18954 23330 27706 32082 35959 NC_012213 1450 1451 5827 10203 14579 18955 23331 27707 32083 38735 NC_012213 1451 1452 5828 10204 14580 18956 23332 27708 32084 35960 NC_012213 1452 1453 5829 10205 14581 18957 23333 27709 32085 38736 NC_007605 1453 1454 5830 10206 14582 18958 23334 27710 32086 35961 38737 NC_007605 1454 1455 5831 10207 14583 18959 23335 27711 32087 35962 NC_007605 1455 1456 5832 10208 14584 18960 23336 27712 32088 35963 NC_007605 1456 1457 5833 10209 14585 18961 23337 27713 32089 38738 NC_007605 1457 1458 5834 10210 14586 18962 23338 27714 32090 35964 NC_007605 1458 1459 5835 10211 14587 18963 23339 27715 32091 35965 NC_007605 1459 1460 5836 10212 14588 18964 23340 27716 32092 35966 NC_007605 1460 1461 5837 10213 14589 18965 23341 27717 32093 35967 NC_007605 1461 1462 5838 10214 14590 18966 23342 27718 32094 35968 NC_007605 1462 1463 5839 10215 14591 18967 23343 27719 32095 35969 NC_007605 1463 1464 5840 10216 14592 18968 23344 27720 32096 38739 NC_007605 1464 1465 5841 10217 14593 18969 23345 27721 32097 35970 38740 NC_007605 1465 1466 5842 10218 14594 18970 23346 27722 32098 35971 NC_007605 1466 1467 5843 10219 14595 18971 23347 27723 32099 35972 38741 NC_007605 1467 1468 5844 10220 14596 18972 23348 27724 32100 38742 NC_007605 1468 1469 5845 10221 14597 18973 23349 27725 32101 38743 NC_007605 1469 1470 5846 10222 14598 18974 23350 27726 32102 38744 NC_007605 1470 1471 5847 10223 14599 18975 23351 27727 32103 38745 NC_007605 1471 1472 5848 10224 14600 18976 23352 27728 32104 35973 38746 NC_007605 1472 1473 5849 10225 14601 18977 23353 27729 32105 38747 NC_007605 1473 1474 5850 10226 14602 18978 23354 27730 32106 35974 NC_007605 1474 1475 5851 10227 14603 18979 23355 27731 32107 35975 NC_007605 1475 1476 5852 10228 14604 18980 23356 27732 32108 35976 38748 NC_007605 1476 1477 5853 10229 14605 18981 23357 27733 32109 35977 38749 NC_007605 1477 1478 5854 10230 14606 18982 23358 27734 32110 38750 NC_007605 1478 1479 5855 10231 14607 18983 23359 27735 32111 35978 38751 NC_007605 1479 1480 5856 10232 14608 18984 23360 27736 32112 35979 38752 NC_007605 1480 1481 5857 10233 14609 18985 23361 27737 32113 35980 38753 NC_007605 1481 1482 5858 10234 14610 18986 23362 27738 32114 35981 38754 NC_007605 1482 1483 5859 10235 14611 18987 23363 27739 32115 35982 NC_007605 1483 1484 5860 10236 14612 18988 23364 27740 32116 35983 38755 NC_007605 1484 1485 5861 10237 14613 18989 23365 27741 32117 35984 38756 NC_007605 1485 1486 5862 10238 14614 18990 23366 27742 32118 35985 NC_007605 1486 1487 5863 10239 14615 18991 23367 27743 32119 35986 NC_007605 1487 1488 5864 10240 14616 18992 23368 27744 32120 38757 NC_007605 1488 1489 5865 10241 14617 18993 23369 27745 32121 38758 NC_007605 1489 1490 5866 10242 14618 18994 23370 27746 32122 35987 38759 NC_007605 1490 1491 5867 10243 14619 18995 23371 27747 32123 35988 NC_007605 1491 1492 5868 10244 14620 18996 23372 27748 32124 38760 NC_007605 1492 1493 5869 10245 14621 18997 23373 27749 32125 38761 NC_007605 1493 1494 5870 10246 14622 18998 23374 27750 32126 35989 NC_007605 1494 1495 5871 10247 14623 18999 23375 27751 32127 38762 NC_007605 1495 1496 5872 10248 14624 19000 23376 27752 32128 35990 NC_007605 1496 1497 5873 10249 14625 19001 23377 27753 32129 35991 38763 NC_007605 1497 1498 5874 10250 14626 19002 23378 27754 32130 38764 NC_007605 1498 1499 5875 10251 14627 19003 23379 27755 32131 38765 NC_007605 1499 1500 5876 10252 14628 19004 23380 27756 32132 38766 NC_007605 1500 1501 5877 10253 14629 19005 23381 27757 32133 35992 NC_007605 1501 1502 5878 10254 14630 19006 23382 27758 32134 35993 NC_007605 1502 1503 5879 10255 14631 19007 23383 27759 32135 38767 NC_007605 1503 1504 5880 10256 14632 19008 23384 27760 32136 35994 NC_007605 1504 1505 5881 10257 14633 19009 23385 27761 32137 35995 NC_007605 1505 1506 5882 10258 14634 19010 23386 27762 32138 35996 38768 NC_007605 1506 1507 5883 10259 14635 19011 23387 27763 32139 35997 38769 NC_007605 1507 1508 5884 10260 14636 19012 23388 27764 32140 35998 38770 NC_007605 1508 1509 5885 10261 14637 19013 23389 27765 32141 35999 38771 NC_007605 1509 1510 5886 10262 14638 19014 23390 27766 32142 38772 NC_007605 1510 1511 5887 10263 14639 19015 23391 27767 32143 36000 NC_007605 1511 1512 5888 10264 14640 19016 23392 27768 32144 36001 38773 NC_007605 1512 1513 5889 10265 14641 19017 23393 27769 32145 36002 NC_007605 1513 1514 5890 10266 14642 19018 23394 27770 32146 36003 38774 NC_007605 1514 1515 5891 10267 14643 19019 23395 27771 32147 36004 NC_007605 1515 1516 5892 10268 14644 19020 23396 27772 32148 38775 NC_007605 1516 1517 5893 10269 14645 19021 23397 27773 32149 36005 38776 NC_007605 1517 1518 5894 10270 14646 19022 23398 27774 32150 36006 NC_007605 1518 1519 5895 10271 14647 19023 23399 27775 32151 38777 NC_007605 1519 1520 5896 10272 14648 19024 23400 27776 32152 36007 38778 NC_007605 1520 1521 5897 10273 14649 19025 23401 27777 32153 36008 38779 NC_007605 1521 1522 5898 10274 14650 19026 23402 27778 32154 38780 NC_007605 1522 1523 5899 10275 14651 19027 23403 27779 32155 36009 38781 NC_007605 1523 1524 5900 10276 14652 19028 23404 27780 32156 36010 38782 NC_007605 1524 1525 5901 10277 14653 19029 23405 27781 32157 36011 38783 NC_007605 1525 1526 5902 10278 14654 19030 23406 27782 32158 38784 NC_007605 1526 1527 5903 10279 14655 19031 23407 27783 32159 36012 38785 NC_007605 1527 1528 5904 10280 14656 19032 23408 27784 32160 36013 NC_007605 1528 1529 5905 10281 14657 19033 23409 27785 32161 38786 NC_007605 1529 1530 5906 10282 14658 19034 23410 27786 32162 38787 NC_007605 1530 1531 5907 10283 14659 19035 23411 27787 32163 38788 NC_007605 1531 1532 5908 10284 14660 19036 23412 27788 32164 38789 NC_007605 1532 1533 5909 10285 14661 19037 23413 27789 32165 36014 38790 NC_007605 1533 1534 5910 10286 14662 19038 23414 27790 32166 38791 NC_007605 1534 1535 5911 10287 14663 19039 23415 27791 32167 38792 NC_007605 1535 1536 5912 10288 14664 19040 23416 27792 32168 38793 NC_007605 1536 1537 5913 10289 14665 19041 23417 27793 32169 36015 NC_007605 1537 1538 5914 10290 14666 19042 23418 27794 32170 36016 38794 NC_007605 1538 1539 5915 10291 14667 19043 23419 27795 32171 36017 38795 NC_007605 1539 1540 5916 10292 14668 19044 23420 27796 32172 38796 NC_007605 1540 1541 5917 10293 14669 19045 23421 27797 32173 38797 NC_007605 1541 1542 5918 10294 14670 19046 23422 27798 32174 36018 NC_007605 1542 1543 5919 10295 14671 19047 23423 27799 32175 38798 NC_007605 1543 1544 5920 10296 14672 19048 23424 27800 32176 36019 38799 NC_033781 1544 1545 5921 10297 14673 19049 23425 27801 32177 38800 NC_033781 1545 1546 5922 10298 14674 19050 23426 27802 32178 38801 NC_033781 1546 1547 5923 10299 14675 19051 23427 27803 32179 36020 NC_033781 1547 1548 5924 10300 14676 19052 23428 27804 32180 36021 NC_033781 1548 1549 5925 10301 14677 19053 23429 27805 32181 38802 NC_033781 1549 1550 5926 10302 14678 19054 23430 27806 32182 38803 NC_033781 1550 1551 5927 10303 14679 19055 23431 27807 32183 36022 NC_033781 1551 1552 5928 10304 14680 19056 23432 27808 32184 38804 NC_033781 1552 1553 5929 10305 14681 19057 23433 27809 32185 36023 NC_033781 1553 1554 5930 10306 14682 19058 23434 27810 32186 36024 NC_033781 1554 1555 5931 10307 14683 19059 23435 27811 32187 36025 NC_033781 1555 1556 5932 10308 14684 19060 23436 27812 32188 38805 NC_002017 1556 1557 5933 10309 14685 19061 23437 27813 32189 38806 NC_002017 1557 1558 5934 10310 14686 19062 23438 27814 32190 36026 NC_002017 1558 1559 5935 10311 14687 19063 23439 27815 32191 36027 NC_002017 1559 1560 5936 10312 14688 19064 23440 27816 32192 38807 NC_002017 1560 1561 5937 10313 14689 19065 23441 27817 32193 36028 NC_002017 1561 1562 5938 10314 14690 19066 23442 27818 32194 36029 38808 NC_001596 1562 1563 5939 10315 14691 19067 23443 27819 32195 36030 NC_001596 1563 1564 5940 10316 14692 19068 23444 27820 32196 38809 NC_001596 1564 1565 5941 10317 14693 19069 23445 27821 32197 36031 NC_001596 1565 1566 5942 10318 14694 19070 23446 27822 32198 36032 NC_001596 1566 1567 5943 10319 14695 19071 23447 27823 32199 38810 NC_001596 1567 1568 5944 10320 14696 19072 23448 27824 32200 36033 NC_001596 1568 1569 5945 10321 14697 19073 23449 27825 32201 36034 NC_001596 1569 1570 5946 10322 14698 19074 23450 27826 32202 38811 NC_001596 1570 1571 5947 10323 14699 19075 23451 27827 32203 38812 NC_001596 1571 1572 5948 10324 14700 19076 23452 27828 32204 38813 NC_001596 1572 1573 5949 10325 14701 19077 23453 27829 32205 36035 NC_001596 1573 1574 5950 10326 14702 19078 23454 27830 32206 38814 NC_001596 1574 1575 5951 10327 14703 19079 23455 27831 32207 36036 NC_001596 1575 1576 5952 10328 14704 19080 23456 27832 32208 36037 NC_001596 1576 1577 5953 10329 14705 19081 23457 27833 32209 36038 NC_001596 1577 1578 5954 10330 14706 19082 23458 27834 32210 36039 38815 NC_001596 1578 1579 5955 10331 14707 19083 23459 27835 32211 36040 38816 NC_001596 1579 1580 5956 10332 14708 19084 23460 27836 32212 36041 NC_001596 1580 1581 5957 10333 14709 19085 23461 27837 32213 36042 NC_001596 1581 1582 5958 10334 14710 19086 23462 27838 32214 36043 NC_001596 1582 1583 5959 10335 14711 19087 23463 27839 32215 36044 NC_000117 1583 1584 5960 10336 14712 19088 23464 27840 32216 38817 NC_000117 1584 1585 5961 10337 14713 19089 23465 27841 32217 36045 NC_000117 1585 1586 5962 10338 14714 19090 23466 27842 32218 38818 NC_000117 1586 1587 5963 10339 14715 19091 23467 27843 32219 36046 NC_000117 1587 1588 5964 10340 14716 19092 23468 27844 32220 38819 NC_000117 1588 1589 5965 10341 14717 19093 23469 27845 32221 36047 NC_000117 1589 1590 5966 10342 14718 19094 23470 27846 32222 36048 NC_000117 1590 1591 5967 10343 14719 19095 23471 27847 32223 36049 NC_000117 1591 1592 5968 10344 14720 19096 23472 27848 32224 36050 NC_000117 1592 1593 5969 10345 14721 19097 23473 27849 32225 38820 NC_000117 1593 1594 5970 10346 14722 19098 23474 27850 32226 36051 NC_000117 1594 1595 5971 10347 14723 19099 23475 27851 32227 36052 38821 NC_000117 1595 1596 5972 10348 14724 19100 23476 27852 32228 36053 NC_000117 1596 1597 5973 10349 14725 19101 23477 27853 32229 36054 NC_000117 1597 1598 5974 10350 14726 19102 23478 27854 32230 36055 NC_000117 1598 1599 5975 10351 14727 19103 23479 27855 32231 38822 NC_000117 1599 1600 5976 10352 14728 19104 23480 27856 32232 38823 NC_000117 1600 1601 5977 10353 14729 19105 23481 27857 32233 38824 NC_000117 1601 1602 5978 10354 14730 19106 23482 27858 32234 36056 NC_000117 1602 1603 5979 10355 14731 19107 23483 27859 32235 36057 NC_000117 1603 1604 5980 10356 14732 19108 23484 27860 32236 36058 NC_000117 1604 1605 5981 10357 14733 19109 23485 27861 32237 38825 NC_000117 1605 1606 5982 10358 14734 19110 23486 27862 32238 36059 NC_000117 1606 1607 5983 10359 14735 19111 23487 27863 32239 38826 NC_000117 1607 1608 5984 10360 14736 19112 23488 27864 32240 38827 NC_000117 1608 1609 5985 10361 14737 19113 23489 27865 32241 36060 NC_000117 1609 1610 5986 10362 14738 19114 23490 27866 32242 36061 NC_000117 1610 1611 5987 10363 14739 19115 23491 27867 32243 38828 NC_000117 1611 1612 5988 10364 14740 19116 23492 27868 32244 36062 NC_000117 1612 1613 5989 10365 14741 19117 23493 27869 32245 38829 NC_000117 1613 1614 5990 10366 14742 19118 23494 27870 32246 38830 NC_000117 1614 1615 5991 10367 14743 19119 23495 27871 32247 36063 NC_000117 1615 1616 5992 10368 14744 19120 23496 27872 32248 38831 NC_000117 1616 1617 5993 10369 14745 19121 23497 27873 32249 38832 NC_000117 1617 1618 5994 10370 14746 19122 23498 27874 32250 36064 NC_000117 1618 1619 5995 10371 14747 19123 23499 27875 32251 38833 NC_000117 1619 1620 5996 10372 14748 19124 23500 27876 32252 36065 NC_000117 1620 1621 5997 10373 14749 19125 23501 27877 32253 36066 NC_000117 1621 1622 5998 10374 14750 19126 23502 27878 32254 36067 NC_000117 1622 1623 5999 10375 14751 19127 23503 27879 32255 36068 NC_000117 1623 1624 6000 10376 14752 19128 23504 27880 32256 36069 NC_000117 1624 1625 6001 10377 14753 19129 23505 27881 32257 36070 NC_000117 1625 1626 6002 10378 14754 19130 23506 27882 32258 36071 NC_000117 1626 1627 6003 10379 14755 19131 23507 27883 32259 38834 NC_000117 1627 1628 6004 10380 14756 19132 23508 27884 32260 36072 NC_000117 1628 1629 6005 10381 14757 19133 23509 27885 32261 38835 NC_000117 1629 1630 6006 10382 14758 19134 23510 27886 32262 36073 NC_000117 1630 1631 6007 10383 14759 19135 23511 27887 32263 38836 NC_000117 1631 1632 6008 10384 14760 19136 23512 27888 32264 38837 NC_000117 1632 1633 6009 10385 14761 19137 23513 27889 32265 36074 NC_000117 1633 1634 6010 10386 14762 19138 23514 27890 32266 38838 NC_000117 1634 1635 6011 10387 14763 19139 23515 27891 32267 38839 NC_000117 1635 1636 6012 10388 14764 19140 23516 27892 32268 38840 NC_000117 1636 1637 6013 10389 14765 19141 23517 27893 32269 36075 NC_000117 1637 1638 6014 10390 14766 19142 23518 27894 32270 36076 NC_000117 1638 1639 6015 10391 14767 19143 23519 27895 32271 38841 NC_000117 1639 1640 6016 10392 14768 19144 23520 27896 32272 36077 38842 NC_000117 1640 1641 6017 10393 14769 19145 23521 27897 32273 36078 38843 NC_000117 1641 1642 6018 10394 14770 19146 23522 27898 32274 36079 NC_000117 1642 1643 6019 10395 14771 19147 23523 27899 32275 36080 NC_000117 1643 1644 6020 10396 14772 19148 23524 27900 32276 38844 NC_000117 1644 1645 6021 10397 14773 19149 23525 27901 32277 38845 NC_000117 1645 1646 6022 10398 14774 19150 23526 27902 32278 38846 NC_000117 1646 1647 6023 10399 14775 19151 23527 27903 32279 36081 NC_000117 1647 1648 6024 10400 14776 19152 23528 27904 32280 38847 NC_000117 1648 1649 6025 10401 14777 19153 23529 27905 32281 36082 NC_000117 1649 1650 6026 10402 14778 19154 23530 27906 32282 38848 NC_000117 1650 1651 6027 10403 14779 19155 23531 27907 32283 38849 NC_000117 1651 1652 6028 10404 14780 19156 23532 27908 32284 36083 NC_000117 1652 1653 6029 10405 14781 19157 23533 27909 32285 36084 NC_000117 1653 1654 6030 10406 14782 19158 23534 27910 32286 38850 NC_000117 1654 1655 6031 10407 14783 19159 23535 27911 32287 36085 NC_000117 1655 1656 6032 10408 14784 19160 23536 27912 32288 38851 NC_000117 1656 1657 6033 10409 14785 19161 23537 27913 32289 38852 NC_000117 1657 1658 6034 10410 14786 19162 23538 27914 32290 36086 NC_000117 1658 1659 6035 10411 14787 19163 23539 27915 32291 36087 NC_000117 1659 1660 6036 10412 14788 19164 23540 27916 32292 36088 NC_000117 1660 1661 6037 10413 14789 19165 23541 27917 32293 38853 NC_000117 1661 1662 6038 10414 14790 19166 23542 27918 32294 38854 NC_000117 1662 1663 6039 10415 14791 19167 23543 27919 32295 36089 NC_000117 1663 1664 6040 10416 14792 19168 23544 27920 32296 38855 NC_000117 1664 1665 6041 10417 14793 19169 23545 27921 32297 36090 NC_000117 1665 1666 6042 10418 14794 19170 23546 27922 32298 36091 NC_000117 1666 1667 6043 10419 14795 19171 23547 27923 32299 38856 NC_000117 1667 1668 6044 10420 14796 19172 23548 27924 32300 36092 NC_000117 1668 1669 6045 10421 14797 19173 23549 27925 32301 38857 NC_000117 1669 1670 6046 10422 14798 19174 23550 27926 32302 36093 NC_000117 1670 1671 6047 10423 14799 19175 23551 27927 32303 36094 NC_000117 1671 1672 6048 10424 14800 19176 23552 27928 32304 36095 NC_000117 1672 1673 6049 10425 14801 19177 23553 27929 32305 36096 NC_000117 1673 1674 6050 10426 14802 19178 23554 27930 32306 38858 NC_000117 1674 1675 6051 10427 14803 19179 23555 27931 32307 38859 NC_000117 1675 1676 6052 10428 14804 19180 23556 27932 32308 38860 NC_000117 1676 1677 6053 10429 14805 19181 23557 27933 32309 38861 NC_000117 1677 1678 6054 10430 14806 19182 23558 27934 32310 36097 NC_000117 1678 1679 6055 10431 14807 19183 23559 27935 32311 36098 NC_000117 1679 1680 6056 10432 14808 19184 23560 27936 32312 38862 NC_000117 1680 1681 6057 10433 14809 19185 23561 27937 32313 36099 NC_000117 1681 1682 6058 10434 14810 19186 23562 27938 32314 36100 NC_000117 1682 1683 6059 10435 14811 19187 23563 27939 32315 38863 NC_000117 1683 1684 6060 10436 14812 19188 23564 27940 32316 38864 NC_000117 1684 1685 6061 10437 14813 19189 23565 27941 32317 38865 NC_000117 1685 1686 6062 10438 14814 19190 23566 27942 32318 36101 NC_000117 1686 1687 6063 10439 14815 19191 23567 27943 32319 36102 NC_000117 1687 1688 6064 10440 14816 19192 23568 27944 32320 36103 NC_000117 1688 1689 6065 10441 14817 19193 23569 27945 32321 36104 NC_000117 1689 1690 6066 10442 14818 19194 23570 27946 32322 36105 NC_000117 1690 1691 6067 10443 14819 19195 23571 27947 32323 36106 NC_000117 1691 1692 6068 10444 14820 19196 23572 27948 32324 36107 NC_000117 1692 1693 6069 10445 14821 19197 23573 27949 32325 38866 NC_000117 1693 1694 6070 10446 14822 19198 23574 27950 32326 36108 NC_000117 1694 1695 6071 10447 14823 19199 23575 27951 32327 36109 NC_000117 1695 1696 6072 10448 14824 19200 23576 27952 32328 38867 NC_000117 1696 1697 6073 10449 14825 19201 23577 27953 32329 36110 NC_000117 1697 1698 6074 10450 14826 19202 23578 27954 32330 36111 NC_000117 1698 1699 6075 10451 14827 19203 23579 27955 32331 36112 NC_000117 1699 1700 6076 10452 14828 19204 23580 27956 32332 36113 38868 NC_000117 1700 1701 6077 10453 14829 19205 23581 27957 32333 38869 NC_000117 1701 1702 6078 10454 14830 19206 23582 27958 32334 36114 NC_000117 1702 1703 6079 10455 14831 19207 23583 27959 32335 36115 NC_000117 1703 1704 6080 10456 14832 19208 23584 27960 32336 36116 NC_000117 1704 1705 6081 10457 14833 19209 23585 27961 32337 36117 NC_000117 1705 1706 6082 10458 14834 19210 23586 27962 32338 38870 NC_000117 1706 1707 6083 10459 14835 19211 23587 27963 32339 38871 NC_000117 1707 1708 6084 10460 14836 19212 23588 27964 32340 38872 NC_000117 1708 1709 6085 10461 14837 19213 23589 27965 32341 36118 NC_000117 1709 1710 6086 10462 14838 19214 23590 27966 32342 38873 NC_000117 1710 1711 6087 10463 14839 19215 23591 27967 32343 38874 NC_000117 1711 1712 6088 10464 14840 19216 23592 27968 32344 38875 NC_000117 1712 1713 6089 10465 14841 19217 23593 27969 32345 38876 NC_000117 1713 1714 6090 10466 14842 19218 23594 27970 32346 36119 NC_000117 1714 1715 6091 10467 14843 19219 23595 27971 32347 38877 NC_000117 1715 1716 6092 10468 14844 19220 23596 27972 32348 38878 NC_000117 1716 1717 6093 10469 14845 19221 23597 27973 32349 38879 NC_000117 1717 1718 6094 10470 14846 19222 23598 27974 32350 36120 NC_000117 1718 1719 6095 10471 14847 19223 23599 27975 32351 38880 NC_000117 1719 1720 6096 10472 14848 19224 23600 27976 32352 36121 NC_000117 1720 1721 6097 10473 14849 19225 23601 27977 32353 36122 NC_000117 1721 1722 6098 10474 14850 19226 23602 27978 32354 36123 NC_000117 1722 1723 6099 10475 14851 19227 23603 27979 32355 38881 NC_000117 1723 1724 6100 10476 14852 19228 23604 27980 32356 36124 NC_000117 1724 1725 6101 10477 14853 19229 23605 27981 32357 36125 NC_000117 1725 1726 6102 10478 14854 19230 23606 27982 32358 38882 NC_000117 1726 1727 6103 10479 14855 19231 23607 27983 32359 36126 NC_000117 1727 1728 6104 10480 14856 19232 23608 27984 32360 36127 NC_000117 1728 1729 6105 10481 14857 19233 23609 27985 32361 36128 NC_000117 1729 1730 6106 10482 14858 19234 23610 27986 32362 38883 NC_000117 1730 1731 6107 10483 14859 19235 23611 27987 32363 38884 NC_000117 1731 1732 6108 10484 14860 19236 23612 27988 32364 36129 NC_000117 1732 1733 6109 10485 14861 19237 23613 27989 32365 38885 NC_000117 1733 1734 6110 10486 14862 19238 23614 27990 32366 38886 NC_000117 1734 1735 6111 10487 14863 19239 23615 27991 32367 38887 NC_000117 1735 1736 6112 10488 14864 19240 23616 27992 32368 36130 NC_000117 1736 1737 6113 10489 14865 19241 23617 27993 32369 36131 NC_000117 1737 1738 6114 10490 14866 19242 23618 27994 32370 36132 NC_000117 1738 1739 6115 10491 14867 19243 23619 27995 32371 38888 NC_000117 1739 1740 6116 10492 14868 19244 23620 27996 32372 36133 NC_000117 1740 1741 6117 10493 14869 19245 23621 27997 32373 38889 NC_000117 1741 1742 6118 10494 14870 19246 23622 27998 32374 38890 NC_000117 1742 1743 6119 10495 14871 19247 23623 27999 32375 38891 NC_000117 1743 1744 6120 10496 14872 19248 23624 28000 32376 38892 NC_000117 1744 1745 6121 10497 14873 19249 23625 28001 32377 36134 NC_000117 1745 1746 6122 10498 14874 19250 23626 28002 32378 36135 NC_000117 1746 1747 6123 10499 14875 19251 23627 28003 32379 38893 NC_000117 1747 1748 6124 10500 14876 19252 23628 28004 32380 38894 NC_000117 1748 1749 6125 10501 14877 19253 23629 28005 32381 38895 NC_000117 1749 1750 6126 10502 14878 19254 23630 28006 32382 38896 NC_000117 1750 1751 6127 10503 14879 19255 23631 28007 32383 36136 NC_000117 1751 1752 6128 10504 14880 19256 23632 28008 32384 38897 NC_000117 1752 1753 6129 10505 14881 19257 23633 28009 32385 38898 NC_000117 1753 1754 6130 10506 14882 19258 23634 28010 32386 36137 NC_007381 1754 1755 6131 10507 14883 19259 23635 28011 32387 36138 NC_007381 1755 1756 6132 10508 14884 19260 23636 28012 32388 36139 38899 NC_007381 1756 1757 6133 10509 14885 19261 23637 28013 32389 36140 NC_007381 1757 1758 6134 10510 14886 19262 23638 28014 32390 38900 NC_026434 1758 1759 6135 10511 14887 19263 23639 28015 32391 38901 NC_026434 1759 1760 6136 10512 14888 19264 23640 28016 32392 36141 NC_026434 1760 1761 6137 10513 14889 19265 23641 28017 32393 36142 NC_026434 1761 1762 6138 10514 14890 19266 23642 28018 32394 36143 NC_007377 1762 1763 6139 10515 14891 19267 23643 28019 32395 38902 NC_006310 1763 1764 6140 10516 14892 19268 23644 28020 32396 38903 NC_006310 1764 1765 6141 10517 14893 19269 23645 28021 32397 36144 NC_006310 1765 1766 6142 10518 14894 19270 23646 28022 32398 36145 NC_006310 1766 1767 6143 10519 14895 19271 23647 28023 32399 38904 NC_006310 1767 1768 6144 10520 14896 19272 23648 28024 32400 38905 NC_006310 1768 1769 6145 10521 14897 19273 23649 28025 32401 36146 NC_006310 1769 1770 6146 10522 14898 19274 23650 28026 32402 36147 NC_006310 1770 1771 6147 10523 14899 19275 23651 28027 32403 38906 NC_026431 1771 1772 6148 10524 14900 19276 23652 28028 32404 38907 NC_026431 1772 1773 6149 10525 14901 19277 23653 28029 32405 36148 NC_004500 1773 1774 6150 10526 14902 19278 23654 28030 32406 36149 NC_004500 1774 1775 6151 10527 14903 19279 23655 28031 32407 38908 NC_004500 1775 1776 6152 10528 14904 19280 23656 28032 32408 36150 NC_004500 1776 1777 6153 10529 14905 19281 23657 28033 32409 38909 NC_004500 1777 1778 6154 10530 14906 19282 23658 28034 32410 36151 NC_004500 1778 1779 6155 10531 14907 19283 23659 28035 32411 36152 NC_004500 1779 1780 6156 10532 14908 19284 23660 28036 32412 38910 NC_004500 1780 1781 6157 10533 14909 19285 23661 28037 32413 38911 NC_004500 1781 1782 6158 10534 14910 19286 23662 28038 32414 36153 NC_004500 1782 1783 6159 10535 14911 19287 23663 28039 32415 36154 NC_004500 1783 1784 6160 10536 14912 19288 23664 28040 32416 36155 NC_004500 1784 1785 6161 10537 14913 19289 23665 28041 32417 36156 NC_004500 1785 1786 6162 10538 14914 19290 23666 28042 32418 38912 NC_004500 1786 1787 6163 10539 14915 19291 23667 28043 32419 36157 NC_004500 1787 1788 6164 10540 14916 19292 23668 28044 32420 36158 38913 NC_004500 1788 1789 6165 10541 14917 19293 23669 28045 32421 38914 NC_004500 1789 1790 6166 10542 14918 19294 23670 28046 32422 36159 NC_006213 1790 1791 6167 10543 14919 19295 23671 28047 32423 38915 NC_006213 1791 1792 6168 10544 14920 19296 23672 28048 32424 38916 NC_006213 1792 1793 6169 10545 14921 19297 23673 28049 32425 36160 NC_006213 1793 1794 6170 10546 14922 19298 23674 28050 32426 36161 NC_006213 1794 1795 6171 10547 14923 19299 23675 28051 32427 38917 NC_006213 1795 1796 6172 10548 14924 19300 23676 28052 32428 36162 38918 NC_006213 1796 1797 6173 10549 14925 19301 23677 28053 32429 36163 NC_006213 1797 1798 6174 10550 14926 19302 23678 28054 32430 38919 NC_006213 1798 1799 6175 10551 14927 19303 23679 28055 32431 38920 NC_006213 1799 1800 6176 10552 14928 19304 23680 28056 32432 38921 NC_006213 1800 1801 6177 10553 14929 19305 23681 28057 32433 38922 NC_006213 1801 1802 6178 10554 14930 19306 23682 28058 32434 36164 NC_006213 1802 1803 6179 10555 14931 19307 23683 28059 32435 36165 38923 NC_006213 1803 1804 6180 10556 14932 19308 23684 28060 32436 38924 NC_006213 1804 1805 6181 10557 14933 19309 23685 28061 32437 36166 NC_006213 1805 1806 6182 10558 14934 19310 23686 28062 32438 36167 NC_006213 1806 1807 6183 10559 14935 19311 23687 28063 32439 38925 NC_006213 1807 1808 6184 10560 14936 19312 23688 28064 32440 36168 NC_006213 1808 1809 6185 10561 14937 19313 23689 28065 32441 36169 NC_006213 1809 1810 6186 10562 14938 19314 23690 28066 32442 36170 NC_006213 1810 1811 6187 10563 14939 19315 23691 28067 32443 38926 NC_006213 1811 1812 6188 10564 14940 19316 23692 28068 32444 36171 NC_006213 1812 1813 6189 10565 14941 19317 23693 28069 32445 36172 NC_006213 1813 1814 6190 10566 14942 19318 23694 28070 32446 36173 NC_006213 1814 1815 6191 10567 14943 19319 23695 28071 32447 36174 NC_006213 1815 1816 6192 10568 14944 19320 23696 28072 32448 38927 NC_006213 1816 1817 6193 10569 14945 19321 23697 28073 32449 36175 NC_006213 1817 1818 6194 10570 14946 19322 23698 28074 32450 38928 NC_006213 1818 1819 6195 10571 14947 19323 23699 28075 32451 38929 NC_006213 1819 1820 6196 10572 14948 19324 23700 28076 32452 36176 38930 NC_006213 1820 1821 6197 10573 14949 19325 23701 28077 32453 36177 NC_006213 1821 1822 6198 10574 14950 19326 23702 28078 32454 36178 NC_006213 1822 1823 6199 10575 14951 19327 23703 28079 32455 36179 NC_006213 1823 1824 6200 10576 14952 19328 23704 28080 32456 36180 NC_006213 1824 1825 6201 10577 14953 19329 23705 28081 32457 36181 38931 NC_006213 1825 1826 6202 10578 14954 19330 23706 28082 32458 36182 NC_006213 1826 1827 6203 10579 14955 19331 23707 28083 32459 36183 NC_006213 1827 1828 6204 10580 14956 19332 23708 28084 32460 36184 NC_006213 1828 1829 6205 10581 14957 19333 23709 28085 32461 36185 NC_006213 1829 1830 6206 10582 14958 19334 23710 28086 32462 38932 NC_006213 1830 1831 6207 10583 14959 19335 23711 28087 32463 38933 NC_006213 1831 1832 6208 10584 14960 19336 23712 28088 32464 38934 NC_006213 1832 1833 6209 10585 14961 19337 23713 28089 32465 36186 NC_006213 1833 1834 6210 10586 14962 19338 23714 28090 32466 36187 NC_006213 1834 1835 6211 10587 14963 19339 23715 28091 32467 36188 NC_006213 1835 1836 6212 10588 14964 19340 23716 28092 32468 36189 NC_006213 1836 1837 6213 10589 14965 19341 23717 28093 32469 38935 NC_006213 1837 1838 6214 10590 14966 19342 23718 28094 32470 36190 38936 NC_006213 1838 1839 6215 10591 14967 19343 23719 28095 32471 36191 NC_006213 1839 1840 6216 10592 14968 19344 23720 28096 32472 38937 NC_006213 1840 1841 6217 10593 14969 19345 23721 28097 32473 36192 38938 NC_006213 1841 1842 6218 10594 14970 19346 23722 28098 32474 36193 38939 NC_006213 1842 1843 6219 10595 14971 19347 23723 28099 32475 36194 NC_006213 1843 1844 6220 10596 14972 19348 23724 28100 32476 38940 NC_006213 1844 1845 6221 10597 14973 19349 23725 28101 32477 36195 NC_006213 1845 1846 6222 10598 14974 19350 23726 28102 32478 38941 NC_006213 1846 1847 6223 10599 14975 19351 23727 28103 32479 38942 NC_006213 1847 1848 6224 10600 14976 19352 23728 28104 32480 36196 NC_006213 1848 1849 6225 10601 14977 19353 23729 28105 32481 38943 NC_006213 1849 1850 6226 10602 14978 19354 23730 28106 32482 38944 NC_006213 1850 1851 6227 10603 14979 19355 23731 28107 32483 38945 NC_006213 1851 1852 6228 10604 14980 19356 23732 28108 32484 36197 NC_006213 1852 1853 6229 10605 14981 19357 23733 28109 32485 38946 NC_006213 1853 1854 6230 10606 14982 19358 23734 28110 32486 38947 NC_006213 1854 1855 6231 10607 14983 19359 23735 28111 32487 36198 NC_006213 1855 1856 6232 10608 14984 19360 23736 28112 32488 36199 NC_006213 1856 1857 6233 10609 14985 19361 23737 28113 32489 38948 NC_006213 1857 1858 6234 10610 14986 19362 23738 28114 32490 36200 NC_006213 1858 1859 6235 10611 14987 19363 23739 28115 32491 36201 NC_006213 1859 1860 6236 10612 14988 19364 23740 28116 32492 36202 NC_006213 1860 1861 6237 10613 14989 19365 23741 28117 32493 38949 NC_006213 1861 1862 6238 10614 14990 19366 23742 28118 32494 36203 38950 NC_006213 1862 1863 6239 10615 14991 19367 23743 28119 32495 36204 38951 NC_006213 1863 1864 6240 10616 14992 19368 23744 28120 32496 38952 NC_006213 1864 1865 6241 10617 14993 19369 23745 28121 32497 36205 NC_006213 1865 1866 6242 10618 14994 19370 23746 28122 32498 36206 NC_006213 1866 1867 6243 10619 14995 19371 23747 28123 32499 38953 NC_007370 1867 1868 6244 10620 14996 19372 23748 28124 32500 38954 NC_007370 1868 1869 6245 10621 14997 19373 23749 28125 32501 36207 NC_004906 1869 1870 6246 10622 14998 19374 23750 28126 32502 38955 NC_004906 1870 1871 6247 10623 14999 19375 23751 28127 32503 38956 NC_004906 1871 1872 6248 10624 15000 19376 23752 28128 32504 36208 NC_009824 1872 1873 6249 10625 15001 19377 23753 28129 32505 36209 38957 NC_009824 1873 1874 6250 10626 15002 19378 23754 28130 32506 36210 NC_009824 1874 1875 6251 10627 15003 19379 23755 28131 32507 38958 NC_009824 1875 1876 6252 10628 15004 19380 23756 28132 32508 36211 NC_009824 1876 1877 6253 10629 15005 19381 23757 28133 32509 38959 NC_009824 1877 1878 6254 10630 15006 19382 23758 28134 32510 36212 38960 NC_009824 1878 1879 6255 10631 15007 19383 23759 28135 32511 38961 NC_009824 1879 1880 6256 10632 15008 19384 23760 28136 32512 36213 NC_009824 1880 1881 6257 10633 15009 19385 23761 28137 32513 38962 NC_009824 1881 1882 6258 10634 15010 19386 23762 28138 32514 36214 38963 NC_009824 1882 1883 6259 10635 15011 19387 23763 28139 32515 38964 NC_009824 1883 1884 6260 10636 15012 19388 23764 28140 32516 36215 38965 NC_009824 1884 1885 6261 10637 15013 19389 23765 28141 32517 36216 NC_009824 1885 1886 6262 10638 15014 19390 23766 28142 32518 36217 NC_009824 1886 1887 6263 10639 15015 19391 23767 28143 32519 38966 NC_009824 1887 1888 6264 10640 15016 19392 23768 28144 32520 36218 NC_009824 1888 1889 6265 10641 15017 19393 23769 28145 32521 36219 38967 NC_009824 1889 1890 6266 10642 15018 19394 23770 28146 32522 36220 38968 NC_009824 1890 1891 6267 10643 15019 19395 23771 28147 32523 38969 NC_009824 1891 1892 6268 10644 15020 19396 23772 28148 32524 36221 38970 NC_009824 1892 1893 6269 10645 15021 19397 23773 28149 32525 36222 NC_009824 1893 1894 6270 10646 15022 19398 23774 28150 32526 36223 NC_009824 1894 1895 6271 10647 15023 19399 23775 28151 32527 36224 NC_009824 1895 1896 6272 10648 15024 19400 23776 28152 32528 38971 NC_009824 1896 1897 6273 10649 15025 19401 23777 28153 32529 38972 NC_009824 1897 1898 6274 10650 15026 19402 23778 28154 32530 36225 38973 NC_002023 1898 1899 6275 10651 15027 19403 23779 28155 32531 38974 NC_002023 1899 1900 6276 10652 15028 19404 23780 28156 32532 36226 NC_002023 1900 1901 6277 10653 15029 19405 23781 28157 32533 36227 NC_002023 1901 1902 6278 10654 15030 19406 23782 28158 32534 36228 38975 NC_002023 1902 1903 6279 10655 15031 19407 23783 28159 32535 36229 38976 NC_002023 1903 1904 6280 10656 15032 19408 23784 28160 32536 36230 NC_002023 1904 1905 6281 10657 15033 19409 23785 28161 32537 36231 38977 NC_002023 1905 1906 6282 10658 15034 19410 23786 28162 32538 38978 NC_002023 1906 1907 6283 10659 15035 19411 23787 28163 32539 36232 NC_004102 1907 1908 6284 10660 15036 19412 23788 28164 32540 36233 NC_004102 1908 1909 6285 10661 15037 19413 23789 28165 32541 36234 NC_004102 1909 1910 6286 10662 15038 19414 23790 28166 32542 36235 38979 NC_004102 1910 1911 6287 10663 15039 19415 23791 28167 32543 36236 NC_004102 1911 1912 6288 10664 15040 19416 23792 28168 32544 38980 NC_004102 1912 1913 6289 10665 15041 19417 23793 28169 32545 36237 NC_004102 1913 1914 6290 10666 15042 19418 23794 28170 32546 36238 38981 NC_004102 1914 1915 6291 10667 15043 19419 23795 28171 32547 36239 38982 NC_004102 1915 1916 6292 10668 15044 19420 23796 28172 32548 38983 NC_004102 1916 1917 6293 10669 15045 19421 23797 28173 32549 38984 NC_004102 1917 1918 6294 10670 15046 19422 23798 28174 32550 38985 NC_004102 1918 1919 6295 10671 15047 19423 23799 28175 32551 36240 NC_004102 1919 1920 6296 10672 15048 19424 23800 28176 32552 36241 NC_004102 1920 1921 6297 10673 15049 19425 23801 28177 32553 36242 38986 NC_004102 1921 1922 6298 10674 15050 19426 23802 28178 32554 36243 38987 NC_004102 1922 1923 6299 10675 15051 19427 23803 28179 32555 38988 NC_004102 1923 1924 6300 10676 15052 19428 23804 28180 32556 38989 NC_004102 1924 1925 6301 10677 15053 19429 23805 28181 32557 36244 NC_004102 1925 1926 6302 10678 15054 19430 23806 28182 32558 36245 38990 NC_004102 1926 1927 6303 10679 15055 19431 23807 28183 32559 36246 38991 NC_004102 1927 1928 6304 10680 15056 19432 23808 28184 32560 36247 38992 NC_004102 1928 1929 6305 10681 15057 19433 23809 28185 32561 36248 NC_004102 1929 1930 6306 10682 15058 19434 23810 28186 32562 36249 NC_004102 1930 1931 6307 10683 15059 19435 23811 28187 32563 36250 NC_001576 1931 1932 6308 10684 15060 19436 23812 28188 32564 38993 NC_001576 1932 1933 6309 10685 15061 19437 23813 28189 32565 38994 NC_001576 1933 1934 6310 10686 15062 19438 23814 28190 32566 38995 NC_001576 1934 1935 6311 10687 15063 19439 23815 28191 32567 38996 NC_001576 1935 1936 6312 10688 15064 19440 23816 28192 32568 38997 NC_001576 1936 1937 6313 10689 15065 19441 23817 28193 32569 36251 NC_001576 1937 1938 6314 10690 15066 19442 23818 28194 32570 38998 NC_001576 1938 1939 6315 10691 15067 19443 23819 28195 32571 38999 NC_001576 1939 1940 6316 10692 15068 19444 23820 28196 32572 36252 39000 NC_001576 1940 1941 6317 10693 15069 19445 23821 28197 32573 36253 NC_001576 1941 1942 6318 10694 15070 19446 23822 28198 32574 36254 NC_001576 1942 1943 6319 10695 15071 19447 23823 28199 32575 39001 NC_001576 1943 1944 6320 10696 15072 19448 23824 28200 32576 36255 NC_001576 1944 1945 6321 10697 15073 19449 23825 28201 32577 39002 NC_001576 1945 1946 6322 10698 15074 19450 23826 28202 32578 36256 NC_001576 1946 1947 6323 10699 15075 19451 23827 28203 32579 39003 NC_001576 1947 1948 6324 10700 15076 19452 23828 28204 32580 39004 NC_038914 1948 1949 6325 10701 15077 19453 23829 28205 32581 36257 NC_038914 1949 1950 6326 10702 15078 19454 23830 28206 32582 39005 NC_038914 1950 1951 6327 10703 15079 19455 23831 28207 32583 36258 NC_038914 1951 1952 6328 10704 15080 19456 23832 28208 32584 36259 39006 NC_038914 1952 1953 6329 10705 15081 19457 23833 28209 32585 36260 NC_038914 1953 1954 6330 10706 15082 19458 23834 28210 32586 36261 NC_038914 1954 1955 6331 10707 15083 19459 23835 28211 32587 36262 NC_038914 1955 1956 6332 10708 15084 19460 23836 28212 32588 36263 NC_038914 1956 1957 6333 10709 15085 19461 23837 28213 32589 39007 NC_038914 1957 1958 6334 10710 15086 19462 23838 28214 32590 36264 NC_038914 1958 1959 6335 10711 15087 19463 23839 28215 32591 36265 NC_038914 1959 1960 6336 10712 15088 19464 23840 28216 32592 36266 NC_038914 1960 1961 6337 10713 15089 19465 23841 28217 32593 36267 NC_038914 1961 1962 6338 10714 15090 19466 23842 28218 32594 39008 NC_002205 1962 1963 6339 10715 15091 19467 23843 28219 32595 36268 NC_002205 1963 1964 6340 10716 15092 19468 23844 28220 32596 36269 39009 NC_002205 1964 1965 6341 10717 15093 19469 23845 28221 32597 39010 NC_002205 1965 1966 6342 10718 15094 19470 23846 28222 32598 39011 NC_002205 1966 1967 6343 10719 15095 19471 23847 28223 32599 36270 NC_002205 1967 1968 6344 10720 15096 19472 23848 28224 32600 36271 NC_002205 1968 1969 6345 10721 15097 19473 23849 28225 32601 39012 NC_002205 1969 1970 6346 10722 15098 19474 23850 28226 32602 36272 NC_002205 1970 1971 6347 10723 15099 19475 23851 28227 32603 36273 NC_006577 1971 1972 6348 10724 15100 19476 23852 28228 32604 39013 NC_006577 1972 1973 6349 10725 15101 19477 23853 28229 32605 36274 NC_006577 1973 1974 6350 10726 15102 19478 23854 28230 32606 39014 NC_006577 1974 1975 6351 10727 15103 19479 23855 28231 32607 39015 NC_006577 1975 1976 6352 10728 15104 19480 23856 28232 32608 39016 NC_006577 1976 1977 6353 10729 15105 19481 23857 28233 32609 39017 NC_006577 1977 1978 6354 10730 15106 19482 23858 28234 32610 39018 NC_006577 1978 1979 6355 10731 15107 19483 23859 28235 32611 39019 NC_006577 1979 1980 6356 10732 15108 19484 23860 28236 32612 39020 NC_006577 1980 1981 6357 10733 15109 19485 23861 28237 32613 39021 NC_006577 1981 1982 6358 10734 15110 19486 23862 28238 32614 36275 NC_006577 1982 1983 6359 10735 15111 19487 23863 28239 32615 36276 NC_006577 1983 1984 6360 10736 15112 19488 23864 28240 32616 39022 NC_006577 1984 1985 6361 10737 15113 19489 23865 28241 32617 36277 NC_006577 1985 1986 6362 10738 15114 19490 23866 28242 32618 39023 NC_006577 1986 1987 6363 10739 15115 19491 23867 28243 32619 36278 39024 NC_006577 1987 1988 6364 10740 15116 19492 23868 28244 32620 36279 39025 NC_006577 1988 1989 6365 10741 15117 19493 23869 28245 32621 39026 NC_006577 1989 1990 6366 10742 15118 19494 23870 28246 32622 39027 NC_006577 1990 1991 6367 10743 15119 19495 23871 28247 32623 36280 NC_006577 1991 1992 6368 10744 15120 19496 23872 28248 32624 36281 NC_006577 1992 1993 6369 10745 15121 19497 23873 28249 32625 39028 NC_006577 1993 1994 6370 10746 15122 19498 23874 28250 32626 39029 NC_006577 1994 1995 6371 10747 15123 19499 23875 28251 32627 36282 39030 NC_006577 1995 1996 6372 10748 15124 19500 23876 28252 32628 36283 NC_006577 1996 1997 6373 10749 15125 19501 23877 28253 32629 36284 NC_006577 1997 1998 6374 10750 15126 19502 23878 28254 32630 39031 NC_006577 1998 1999 6375 10751 15127 19503 23879 28255 32631 39032 NC_006577 1999 2000 6376 10752 15128 19504 23880 28256 32632 39033 NC_006577 2000 2001 6377 10753 15129 19505 23881 28257 32633 36285 NC_006577 2001 2002 6378 10754 15130 19506 23882 28258 32634 36286 NC_006577 2002 2003 6379 10755 15131 19507 23883 28259 32635 36287 NC_006577 2003 2004 6380 10756 15132 19508 23884 28260 32636 36288 NC_006577 2004 2005 6381 10757 15133 19509 23885 28261 32637 36289 NC_006577 2005 2006 6382 10758 15134 19510 23886 28262 32638 36290 NC_007371 2006 2007 6383 10759 15135 19511 23887 28263 32639 36291 NC_007371 2007 2008 6384 10760 15136 19512 23888 28264 32640 39034 NC_007371 2008 2009 6385 10761 15137 19513 23889 28265 32641 39035 NC_007371 2009 2010 6386 10762 15138 19514 23890 28266 32642 36292 NC_007371 2010 2011 6387 10763 15139 19515 23891 28267 32643 36293 39036 NC_007371 2011 2012 6388 10764 15140 19516 23892 28268 32644 36294 NC_007371 2012 2013 6389 10765 15141 19517 23893 28269 32645 36295 NC_004905 2013 2014 6390 10766 15142 19518 23894 28270 32646 36296 39037 NC_004905 2014 2015 6391 10767 15143 19519 23895 28271 32647 36297 NC_004905 2015 2016 6392 10768 15144 19520 23896 28272 32648 39038 NC_004905 2016 2017 6393 10769 15145 19521 23897 28273 32649 36298 NC_014955 2017 2018 6394 10770 15146 19522 23898 28274 32650 39039 NC_014955 2018 2019 6395 10771 15147 19523 23899 28275 32651 36299 39040 NC_014955 2019 2020 6396 10772 15148 19524 23900 28276 32652 36300 NC_014955 2020 2021 6397 10773 15149 19525 23901 28277 32653 39041 NC_014955 2021 2022 6398 10774 15150 19526 23902 28278 32654 39042 NC_014955 2022 2023 6399 10775 15151 19527 23903 28279 32655 39043 NC_014955 2023 2024 6400 10776 15152 19528 23904 28280 32656 36301 NC_014955 2024 2025 6401 10777 15153 19529 23905 28281 32657 39044 NC_014955 2025 2026 6402 10778 15154 19530 23906 28282 32658 36302 39045 NC_014955 2026 2027 6403 10779 15155 19531 23907 28283 32659 39046 NC_014955 2027 2028 6404 10780 15156 19532 23908 28284 32660 39047 NC_014955 2028 2029 6405 10781 15157 19533 23909 28285 32661 36303 39048 NC_014955 2029 2030 6406 10782 15158 19534 23910 28286 32662 39049 NC_026437 2030 2031 6407 10783 15159 19535 23911 28287 32663 36304 NC_026437 2031 2032 6408 10784 15160 19536 23912 28288 32664 36305 NC_026437 2032 2033 6409 10785 15161 19537 23913 28289 32665 39050 NC_026437 2033 2034 6410 10786 15162 19538 23914 28290 32666 36306 39051 NC_026437 2034 2035 6411 10787 15163 19539 23915 28291 32667 39052 NC_026437 2035 2036 6412 10788 15164 19540 23916 28292 32668 39053 NC_026437 2036 2037 6413 10789 15165 19541 23917 28293 32669 36307 39054 NC_007364 2037 2038 6414 10790 15166 19542 23918 28294 32670 39055 NC_007364 2038 2039 6415 10791 15167 19543 23919 28295 32671 39056 NC_007364 2039 2040 6416 10792 15168 19544 23920 28296 32672 36308 39057 NC_004911 2040 2041 6417 10793 15169 19545 23921 28297 32673 39058 NC_004911 2041 2042 6418 10794 15170 19546 23922 28298 32674 36309 NC_004911 2042 2043 6419 10795 15171 19547 23923 28299 32675 36310 NC_004911 2043 2044 6420 10796 15172 19548 23924 28300 32676 36311 NC_004911 2044 2045 6421 10797 15173 19549 23925 28301 32677 36312 39059 NC_034616 2045 2046 6422 10798 15174 19550 23926 28302 32678 39060 NC_034616 2046 2047 6423 10799 15175 19551 23927 28303 32679 36313 NC_034616 2047 2048 6424 10800 15176 19552 23928 28304 32680 39061 NC_034616 2048 2049 6425 10801 15177 19553 23929 28305 32681 39062 NC_034616 2049 2050 6426 10802 15178 19554 23930 28306 32682 39063 NC_034616 2050 2051 6427 10803 15179 19555 23931 28307 32683 36314 NC_034616 2051 2052 6428 10804 15180 19556 23932 28308 32684 39064 NC_034616 2052 2053 6429 10805 15181 19557 23933 28309 32685 36315 NC_034616 2053 2054 6430 10806 15182 19558 23934 28310 32686 36316 39065 NC_034616 2054 2055 6431 10807 15183 19559 23935 28311 32687 36317 NC_034616 2055 2056 6432 10808 15184 19560 23936 28312 32688 39066 NC_034616 2056 2057 6433 10809 15185 19561 23937 28313 32689 39067 NC_034616 2057 2058 6434 10810 15186 19562 23938 28314 32690 39068 NC_026429 2058 2059 6435 10811 15187 19563 23939 28315 32691 39069 NC_026429 2059 2060 6436 10812 15188 19564 23940 28316 32692 36318 NC_026429 2060 2061 6437 10813 15189 19565 23941 28317 32693 36319 NC_026429 2061 2062 6438 10814 15190 19566 23942 28318 32694 36320 NC_026438 2062 2063 6439 10815 15191 19567 23943 28319 32695 36321 39070 NC_026438 2063 2064 6440 10816 15192 19568 23944 28320 32696 36322 NC_026438 2064 2065 6441 10817 15193 19569 23945 28321 32697 39071 NC_026438 2065 2066 6442 10818 15194 19570 23946 28322 32698 39072 NC_026438 2066 2067 6443 10819 15195 19571 23947 28323 32699 36323 39073 NC_026438 2067 2068 6444 10820 15196 19572 23948 28324 32700 36324 39074 NC_026438 2068 2069 6445 10821 15197 19573 23949 28325 32701 36325 39075 NC_026438 2069 2070 6446 10822 15198 19574 23950 28326 32702 36326 NC_026946 2070 2071 6447 10823 15199 19575 23951 28327 32703 36327 NC_026946 2071 2072 6448 10824 15200 19576 23952 28328 32704 36328 NC_026946 2072 2073 6449 10825 15201 19577 23953 28329 32705 36329 NC_026946 2073 2074 6450 10826 15202 19578 23954 28330 32706 36330 39076 NC_026946 2074 2075 6451 10827 15203 19579 23955 28331 32707 36331 NC_026946 2075 2076 6452 10828 15204 19580 23956 28332 32708 36332 NC_026946 2076 2077 6453 10829 15205 19581 23957 28333 32709 36333 NC_026946 2077 2078 6454 10830 15206 19582 23958 28334 32710 36334 NC_026946 2078 2079 6455 10831 15207 19583 23959 28335 32711 36335 NC_026946 2079 2080 6456 10832 15208 19584 23960 28336 32712 36336 NC_026946 2080 2081 6457 10833 15209 19585 23961 28337 32713 39077 NC_008188 2081 2082 6458 10834 15210 19586 23962 28338 32714 36337 39078 NC_008188 2082 2083 6459 10835 15211 19587 23963 28339 32715 36338 NC_008188 2083 2084 6460 10836 15212 19588 23964 28340 32716 36339 NC_008188 2084 2085 6461 10837 15213 19589 23965 28341 32717 36340 NC_008188 2085 2086 6462 10838 15214 19590 23966 28342 32718 36341 39079 NC_008188 2086 2087 6463 10839 15215 19591 23967 28343 32719 36342 NC_008188 2087 2088 6464 10840 15216 19592 23968 28344 32720 39080 NC_008188 2088 2089 6465 10841 15217 19593 23969 28345 32721 36343 39081 NC_008188 2089 2090 6466 10842 15218 19594 23970 28346 32722 36344 NC_008188 2090 2091 6467 10843 15219 19595 23971 28347 32723 39082 NC_008188 2091 2092 6468 10844 15220 19596 23972 28348 32724 36345 NC_008188 2092 2093 6469 10845 15221 19597 23973 28349 32725 39083 NC_008188 2093 2094 6470 10846 15222 19598 23974 28350 32726 39084 NC_008188 2094 2095 6471 10847 15223 19599 23975 28351 32727 39085 NC_008188 2095 2096 6472 10848 15224 19600 23976 28352 32728 36346 39086 NC_001693 2096 2097 6473 10849 15225 19601 23977 28353 32729 36347 NC_001693 2097 2098 6474 10850 15226 19602 23978 28354 32730 36348 NC_001693 2098 2099 6475 10851 15227 19603 23979 28355 32731 36349 NC_001693 2099 2100 6476 10852 15228 19604 23980 28356 32732 36350 NC_001693 2100 2101 6477 10853 15229 19605 23981 28357 32733 39087 NC_001693 2101 2102 6478 10854 15230 19606 23982 28358 32734 39088 NC_001693 2102 2103 6479 10855 15231 19607 23983 28359 32735 36351 NC_001693 2103 2104 6480 10856 15232 19608 23984 28360 32736 39089 NC_001693 2104 2105 6481 10857 15233 19609 23985 28361 32737 36352 39090 NC_001693 2105 2106 6482 10858 15234 19610 23986 28362 32738 39091 NC_001693 2106 2107 6483 10859 15235 19611 23987 28363 32739 39092 NC_001693 2107 2108 6484 10860 15236 19612 23988 28364 32740 36353 NC_001693 2108 2109 6485 10861 15237 19613 23989 28365 32741 39093 NC_001693 2109 2110 6486 10862 15238 19614 23990 28366 32742 36354 39094 NC_009334 2110 2111 6487 10863 15239 19615 23991 28367 32743 39095 NC_009334 2111 2112 6488 10864 15240 19616 23992 28368 32744 36355 NC_009334 2112 2113 6489 10865 15241 19617 23993 28369 32745 36356 NC_009334 2113 2114 6490 10866 15242 19618 23994 28370 32746 36357 NC_009334 2114 2115 6491 10867 15243 19619 23995 28371 32747 36358 NC_009334 2115 2116 6492 10868 15244 19620 23996 28372 32748 39096 NC_009334 2116 2117 6493 10869 15245 19621 23997 28373 32749 39097 NC_009334 2117 2118 6494 10870 15246 19622 23998 28374 32750 39098 NC_009334 2118 2119 6495 10871 15247 19623 23999 28375 32751 36359 39099 NC_009334 2119 2120 6496 10872 15248 19624 24000 28376 32752 36360 39100 NC_009334 2120 2121 6497 10873 15249 19625 24001 28377 32753 36361 39101 NC_009334 2121 2122 6498 10874 15250 19626 24002 28378 32754 36362 39102 NC_009334 2122 2123 6499 10875 15251 19627 24003 28379 32755 39103 NC_009334 2123 2124 6500 10876 15252 19628 24004 28380 32756 36363 NC_009334 2124 2125 6501 10877 15253 19629 24005 28381 32757 39104 NC_009334 2125 2126 6502 10878 15254 19630 24006 28382 32758 36364 NC_009334 2126 2127 6503 10879 15255 19631 24007 28383 32759 36365 39105 NC_009334 2127 2128 6504 10880 15256 19632 24008 28384 32760 36366 NC_009334 2128 2129 6505 10881 15257 19633 24009 28385 32761 36367 39106 NC_009334 2129 2130 6506 10882 15258 19634 24010 28386 32762 36368 NC_009334 2130 2131 6507 10883 15259 19635 24011 28387 32763 36369 NC_009334 2131 2132 6508 10884 15260 19636 24012 28388 32764 39107 NC_009334 2132 2133 6509 10885 15261 19637 24013 28389 32765 39108 NC_009334 2133 2134 6510 10886 15262 19638 24014 28390 32766 39109 NC_009334 2134 2135 6511 10887 15263 19639 24015 28391 32767 36370 NC_009334 2135 2136 6512 10888 15264 19640 24016 28392 32768 36371 39110 NC_009334 2136 2137 6513 10889 15265 19641 24017 28393 32769 36372 NC_009334 2137 2138 6514 10890 15266 19642 24018 28394 32770 36373 NC_009334 2138 2139 6515 10891 15267 19643 24019 28395 32771 36374 NC_009334 2139 2140 6516 10892 15268 19644 24020 28396 32772 36375 NC_009334 2140 2141 6517 10893 15269 19645 24021 28397 32773 39111 NC_009334 2141 2142 6518 10894 15270 19646 24022 28398 32774 39112 NC_009334 2142 2143 6519 10895 15271 19647 24023 28399 32775 36376 NC_009334 2143 2144 6520 10896 15272 19648 24024 28400 32776 36377 NC_009334 2144 2145 6521 10897 15273 19649 24025 28401 32777 36378 39113 NC_009334 2145 2146 6522 10898 15274 19650 24026 28402 32778 36379 39114 NC_009334 2146 2147 6523 10899 15275 19651 24027 28403 32779 36380 39115 NC_009334 2147 2148 6524 10900 15276 19652 24028 28404 32780 36381 NC_009334 2148 2149 6525 10901 15277 19653 24029 28405 32781 36382 39116 NC_009334 2149 2150 6526 10902 15278 19654 24030 28406 32782 39117 NC_009334 2150 2151 6527 10903 15279 19655 24031 28407 32783 36383 39118 NC_009334 2151 2152 6528 10904 15280 19656 24032 28408 32784 39119 NC_009334 2152 2153 6529 10905 15281 19657 24033 28409 32785 39120 NC_009334 2153 2154 6530 10906 15282 19658 24034 28410 32786 36384 39121 NC_009334 2154 2155 6531 10907 15283 19659 24035 28411 32787 39122 NC_009334 2155 2156 6532 10908 15284 19660 24036 28412 32788 39123 NC_009334 2156 2157 6533 10909 15285 19661 24037 28413 32789 36385 NC_009334 2157 2158 6534 10910 15286 19662 24038 28414 32790 36386 39124 NC_009334 2158 2159 6535 10911 15287 19663 24039 28415 32791 36387 39125 NC_009334 2159 2160 6536 10912 15288 19664 24040 28416 32792 36388 39126 NC_009334 2160 2161 6537 10913 15289 19665 24041 28417 32793 36389 39127 NC_009334 2161 2162 6538 10914 15290 19666 24042 28418 32794 36390 NC_009334 2162 2163 6539 10915 15291 19667 24043 28419 32795 36391 39128 NC_009334 2163 2164 6540 10916 15292 19668 24044 28420 32796 39129 NC_009334 2164 2165 6541 10917 15293 19669 24045 28421 32797 36392 39130 NC_009334 2165 2166 6542 10918 15294 19670 24046 28422 32798 39131 NC_009334 2166 2167 6543 10919 15295 19671 24047 28423 32799 36393 NC_009334 2167 2168 6544 10920 15296 19672 24048 28424 32800 36394 NC_009334 2168 2169 6545 10921 15297 19673 24049 28425 32801 36395 NC_009334 2169 2170 6546 10922 15298 19674 24050 28426 32802 36396 39132 NC_009334 2170 2171 6547 10923 15299 19675 24051 28427 32803 36397 39133 NC_009334 2171 2172 6548 10924 15300 19676 24052 28428 32804 39134 NC_009334 2172 2173 6549 10925 15301 19677 24053 28429 32805 36398 NC_009334 2173 2174 6550 10926 15302 19678 24054 28430 32806 36399 NC_009334 2174 2175 6551 10927 15303 19679 24055 28431 32807 36400 39135 NC_009334 2175 2176 6552 10928 15304 19680 24056 28432 32808 36401 39136 NC_009334 2176 2177 6553 10929 15305 19681 24057 28433 32809 39137 NC_009334 2177 2178 6554 10930 15306 19682 24058 28434 32810 36402 NC_009334 2178 2179 6555 10931 15307 19683 24059 28435 32811 36403 39138 NC_009334 2179 2180 6556 10932 15308 19684 24060 28436 32812 36404 NC_009334 2180 2181 6557 10933 15309 19685 24061 28437 32813 36405 NC_009334 2181 2182 6558 10934 15310 19686 24062 28438 32814 36406 39139 NC_009334 2182 2183 6559 10935 15311 19687 24063 28439 32815 36407 39140 NC_009334 2183 2184 6560 10936 15312 19688 24064 28440 32816 39141 NC_009334 2184 2185 6561 10937 15313 19689 24065 28441 32817 36408 39142 NC_009334 2185 2186 6562 10938 15314 19690 24066 28442 32818 36409 39143 NC_009334 2186 2187 6563 10939 15315 19691 24067 28443 32819 36410 39144 NC_009334 2187 2188 6564 10940 15316 19692 24068 28444 32820 36411 NC_009334 2188 2189 6565 10941 15317 19693 24069 28445 32821 36412 NC_009334 2189 2190 6566 10942 15318 19694 24070 28446 32822 39145 NC_009334 2190 2191 6567 10943 15319 19695 24071 28447 32823 36413 NC_009334 2191 2192 6568 10944 15320 19696 24072 28448 32824 39146 NC_039089 2192 2193 6569 10945 15321 19697 24073 28449 32825 36414 NC_039089 2193 2194 6570 10946 15322 19698 24074 28450 32826 39147 NC_039089 2194 2195 6571 10947 15323 19699 24075 28451 32827 39148 NC_039089 2195 2196 6572 10948 15324 19700 24076 28452 32828 36415 NC_039089 2196 2197 6573 10949 15325 19701 24077 28453 32829 36416 NC_039089 2197 2198 6574 10950 15326 19702 24078 28454 32830 39149 NC_039089 2198 2199 6575 10951 15327 19703 24079 28455 32831 39150 NC_039089 2199 2200 6576 10952 15328 19704 24080 28456 32832 36417 NC_039089 2200 2201 6577 10953 15329 19705 24081 28457 32833 39151 NC_039089 2201 2202 6578 10954 15330 19706 24082 28458 32834 36418 NC_039089 2202 2203 6579 10955 15331 19707 24083 28459 32835 36419 NC_039089 2203 2204 6580 10956 15332 19708 24084 28460 32836 36420 39152 NC_039089 2204 2205 6581 10957 15333 19709 24085 28461 32837 39153 NC_039089 2205 2206 6582 10958 15334 19710 24086 28462 32838 36421 NC_039089 2206 2207 6583 10959 15335 19711 24087 28463 32839 39154 NC_039089 2207 2208 6584 10960 15336 19712 24088 28464 32840 36422 NC_039089 2208 2209 6585 10961 15337 19713 24089 28465 32841 39155 NC_039089 2209 2210 6586 10962 15338 19714 24090 28466 32842 36423 NC_039089 2210 2211 6587 10963 15339 19715 24091 28467 32843 39156 NC_012486 2211 2212 6588 10964 15340 19716 24092 28468 32844 39157 NC_012486 2212 2213 6589 10965 15341 19717 24093 28469 32845 39158 NC_012486 2213 2214 6590 10966 15342 19718 24094 28470 32846 36424 NC_012486 2214 2215 6591 10967 15343 19719 24095 28471 32847 39159 NC_012486 2215 2216 6592 10968 15344 19720 24096 28472 32848 36425 NC_012486 2216 2217 6593 10969 15345 19721 24097 28473 32849 36426 NC_012486 2217 2218 6594 10970 15346 19722 24098 28474 32850 36427 NC_012486 2218 2219 6595 10971 15347 19723 24099 28475 32851 36428 NC_012486 2219 2220 6596 10972 15348 19724 24100 28476 32852 39160 NC_012486 2220 2221 6597 10973 15349 19725 24101 28477 32853 36429 NC_012486 2221 2222 6598 10974 15350 19726 24102 28478 32854 39161 NC_012486 2222 2223 6599 10975 15351 19727 24103 28479 32855 36430 NC_012486 2223 2224 6600 10976 15352 19728 24104 28480 32856 36431 NC_004104 2224 2225 6601 10977 15353 19729 24105 28481 32857 39162 NC_004104 2225 2226 6602 10978 15354 19730 24106 28482 32858 36432 39163 NC_004104 2226 2227 6603 10979 15355 19731 24107 28483 32859 39164 NC_004104 2227 2228 6604 10980 15356 19732 24108 28484 32860 36433 39165 NC_004104 2228 2229 6605 10981 15357 19733 24109 28485 32861 39166 NC_004104 2229 2230 6606 10982 15358 19734 24110 28486 32862 36434 NC_004104 2230 2231 6607 10983 15359 19735 24111 28487 32863 36435 39167 NC_004104 2231 2232 6608 10984 15360 19736 24112 28488 32864 39168 NC_004104 2232 2233 6609 10985 15361 19737 24113 28489 32865 39169 NC_004104 2233 2234 6610 10986 15362 19738 24114 28490 32866 39170 NC_004104 2234 2235 6611 10987 15363 19739 24115 28491 32867 36436 39171 NC_004104 2235 2236 6612 10988 15364 19740 24116 28492 32868 39172 NC_004104 2236 2237 6613 10989 15365 19741 24117 28493 32869 39173 NC_004104 2237 2238 6614 10990 15366 19742 24118 28494 32870 36437 NC_004104 2238 2239 6615 10991 15367 19743 24119 28495 32871 39174 NC_004104 2239 2240 6616 10992 15368 19744 24120 28496 32872 36438 39175 NC_004104 2240 2241 6617 10993 15369 19745 24121 28497 32873 36439 NC_004104 2241 2242 6618 10994 15370 19746 24122 28498 32874 36440 NC_004104 2242 2243 6619 10995 15371 19747 24123 28499 32875 36441 39176 NC_004104 2243 2244 6620 10996 15372 19748 24124 28500 32876 36442 39177 NC_004104 2244 2245 6621 10997 15373 19749 24125 28501 32877 39178 NC_004104 2245 2246 6622 10998 15374 19750 24126 28502 32878 36443 NC_004104 2246 2247 6623 10999 15375 19751 24127 28503 32879 36444 39179 NC_009823 2247 2248 6624 11000 15376 19752 24128 28504 32880 39180 NC_009823 2248 2249 6625 11001 15377 19753 24129 28505 32881 36445 NC_009823 2249 2250 6626 11002 15378 19754 24130 28506 32882 39181 NC_009823 2250 2251 6627 11003 15379 19755 24131 28507 32883 36446 NC_009823 2251 2252 6628 11004 15380 19756 24132 28508 32884 36447 39182 NC_009823 2252 2253 6629 11005 15381 19757 24133 28509 32885 36448 NC_009823 2253 2254 6630 11006 15382 19758 24134 28510 32886 36449 39183 NC_009823 2254 2255 6631 11007 15383 19759 24135 28511 32887 39184 NC_009823 2255 2256 6632 11008 15384 19760 24136 28512 32888 39185 NC_009823 2256 2257 6633 11009 15385 19761 24137 28513 32889 39186 NC_009823 2257 2258 6634 11010 15386 19762 24138 28514 32890 39187 NC_009823 2258 2259 6635 11011 15387 19763 24139 28515 32891 39188 NC_009823 2259 2260 6636 11012 15388 19764 24140 28516 32892 39189 NC_009823 2260 2261 6637 11013 15389 19765 24141 28517 32893 36450 NC_009823 2261 2262 6638 11014 15390 19766 24142 28518 32894 36451 NC_009823 2262 2263 6639 11015 15391 19767 24143 28519 32895 39190 NC_009823 2263 2264 6640 11016 15392 19768 24144 28520 32896 36452 NC_009823 2264 2265 6641 11017 15393 19769 24145 28521 32897 36453 NC_009823 2265 2266 6642 11018 15394 19770 24146 28522 32898 36454 39191 NC_009823 2266 2267 6643 11019 15395 19771 24147 28523 32899 36455 39192 NC_009823 2267 2268 6644 11020 15396 19772 24148 28524 32900 39193 NC_009823 2268 2269 6645 11021 15397 19773 24149 28525 32901 39194 NC_009823 2269 2270 6646 11022 15398 19774 24150 28526 32902 36456 NC_009823 2270 2271 6647 11023 15399 19775 24151 28527 32903 39195 NC_009823 2271 2272 6648 11024 15400 19776 24152 28528 32904 36457 NC_009823 2272 2273 6649 11025 15401 19777 24153 28529 32905 39196 NC_009823 2273 2274 6650 11026 15402 19778 24154 28530 32906 36458 NC_009823 2274 2275 6651 11027 15403 19779 24155 28531 32907 36459 NZ_LT591897 2275 2276 6652 11028 15404 19780 24156 28532 32908 39197 NZ_LT591897 2276 2277 6653 11029 15405 19781 24157 28533 32909 36460 39198 NZ_LT591897 2277 2278 6654 11030 15406 19782 24158 28534 32910 39199 NZ_LT591897 2278 2279 6655 11031 15407 19783 24159 28535 32911 39200 NZ_LT591897 2279 2280 6656 11032 15408 19784 24160 28536 32912 36461 39201 NZ_LT591897 2280 2281 6657 11033 15409 19785 24161 28537 32913 39202 NZ_LT591897 2281 2282 6658 11034 15410 19786 24162 28538 32914 36462 39203 NZ_LT591897 2282 2283 6659 11035 15411 19787 24163 28539 32915 39204 NZ_LT591897 2283 2284 6660 11036 15412 19788 24164 28540 32916 36463 NZ_LT591897 2284 2285 6661 11037 15413 19789 24165 28541 32917 36464 NZ_LT591897 2285 2286 6662 11038 15414 19790 24166 28542 32918 36465 39205 NZ_LT591897 2286 2287 6663 11039 15415 19791 24167 28543 32919 36466 39206 NZ_LT591897 2287 2288 6664 11040 15416 19792 24168 28544 32920 36467 39207 NZ_LT591897 2288 2289 6665 11041 15417 19793 24169 28545 32921 36468 NZ_LT591897 2289 2290 6666 11042 15418 19794 24170 28546 32922 39208 NZ_LT591897 2290 2291 6667 11043 15419 19795 24171 28547 32923 39209 NZ_LT591897 2291 2292 6668 11044 15420 19796 24172 28548 32924 36469 39210 NZ_LT591897 2292 2293 6669 11045 15421 19797 24173 28549 32925 36470 39211 NZ_LT591897 2293 2294 6670 11046 15422 19798 24174 28550 32926 36471 39212 NZ_LT591897 2294 2295 6671 11047 15423 19799 24175 28551 32927 39213 NZ_LT591897 2295 2296 6672 11048 15424 19800 24176 28552 32928 36472 39214 NZ_LT591897 2296 2297 6673 11049 15425 19801 24177 28553 32929 39215 NZ_LT591897 2297 2298 6674 11050 15426 19802 24178 28554 32930 36473 NZ_LT591897 2298 2299 6675 11051 15427 19803 24179 28555 32931 39216 NZ_LT591897 2299 2300 6676 11052 15428 19804 24180 28556 32932 36474 39217 NZ_LT591897 2300 2301 6677 11053 15429 19805 24181 28557 32933 36475 NZ_LT591897 2301 2302 6678 11054 15430 19806 24182 28558 32934 36476 NZ_LT591897 2302 2303 6679 11055 15431 19807 24183 28559 32935 36477 NZ_LT591897 2303 2304 6680 11056 15432 19808 24184 28560 32936 36478 NZ_LT591897 2304 2305 6681 11057 15433 19809 24185 28561 32937 36479 39218 NZ_LT591897 2305 2306 6682 11058 15434 19810 24186 28562 32938 39219 NZ_LT591897 2306 2307 6683 11059 15435 19811 24187 28563 32939 36480 NZ_LT591897 2307 2308 6684 11060 15436 19812 24188 28564 32940 36481 39220 NZ_LT591897 2308 2309 6685 11061 15437 19813 24189 28565 32941 36482 NZ_LT591897 2309 2310 6686 11062 15438 19814 24190 28566 32942 36483 39221 NZ_LT591897 2310 2311 6687 11063 15439 19815 24191 28567 32943 36484 39222 NZ_LT591897 2311 2312 6688 11064 15440 19816 24192 28568 32944 36485 NZ_LT591897 2312 2313 6689 11065 15441 19817 24193 28569 32945 36486 NZ_LT591897 2313 2314 6690 11066 15442 19818 24194 28570 32946 36487 39223 NZ_LT591897 2314 2315 6691 11067 15443 19819 24195 28571 32947 36488 39224 NZ_LT591897 2315 2316 6692 11068 15444 19820 24196 28572 32948 39225 NZ_LT591897 2316 2317 6693 11069 15445 19821 24197 28573 32949 36489 39226 NZ_LT591897 2317 2318 6694 11070 15446 19822 24198 28574 32950 39227 NZ_LT591897 2318 2319 6695 11071 15447 19823 24199 28575 32951 36490 39228 NZ_LT591897 2319 2320 6696 11072 15448 19824 24200 28576 32952 39229 NZ_LT591897 2320 2321 6697 11073 15449 19825 24201 28577 32953 36491 39230 NZ_LT591897 2321 2322 6698 11074 15450 19826 24202 28578 32954 36492 NZ_LT591897 2322 2323 6699 11075 15451 19827 24203 28579 32955 39231 NZ_LT591897 2323 2324 6700 11076 15452 19828 24204 28580 32956 39232 NZ_LT591897 2324 2325 6701 11077 15453 19829 24205 28581 32957 36493 39233 NZ_LT591897 2325 2326 6702 11078 15454 19830 24206 28582 32958 36494 NZ_LT591897 2326 2327 6703 11079 15455 19831 24207 28583 32959 36495 NZ_LT591897 2327 2328 6704 11080 15456 19832 24208 28584 32960 36496 NZ_LT591897 2328 2329 6705 11081 15457 19833 24209 28585 32961 36497 39234 NZ_LT591897 2329 2330 6706 11082 15458 19834 24210 28586 32962 36498 39235 NZ_LT591897 2330 2331 6707 11083 15459 19835 24211 28587 32963 36499 39236 NZ_LT591897 2331 2332 6708 11084 15460 19836 24212 28588 32964 36500 NZ_LT591897 2332 2333 6709 11085 15461 19837 24213 28589 32965 39237 NZ_LT591897 2333 2334 6710 11086 15462 19838 24214 28590 32966 36501 39238 NZ_LT591897 2334 2335 6711 11087 15463 19839 24215 28591 32967 39239 NZ_LT591897 2335 2336 6712 11088 15464 19840 24216 28592 32968 36502 39240 NZ_LT591897 2336 2337 6713 11089 15465 19841 24217 28593 32969 36503 39241 NZ_LT591897 2337 2338 6714 11090 15466 19842 24218 28594 32970 39242 NZ_LT591897 2338 2339 6715 11091 15467 19843 24219 28595 32971 36504 39243 NZ_LT591897 2339 2340 6716 11092 15468 19844 24220 28596 32972 36505 39244 NZ_LT591897 2340 2341 6717 11093 15469 19845 24221 28597 32973 36506 39245 NZ_LT591897 2341 2342 6718 11094 15470 19846 24222 28598 32974 36507 39246 NZ_LT591897 2342 2343 6719 11095 15471 19847 24223 28599 32975 36508 39247 NZ_LT591897 2343 2344 6720 11096 15472 19848 24224 28600 32976 36509 39248 NZ_LT591897 2344 2345 6721 11097 15473 19849 24225 28601 32977 36510 NZ_LT591897 2345 2346 6722 11098 15474 19850 24226 28602 32978 36511 39249 NZ_LT591897 2346 2347 6723 11099 15475 19851 24227 28603 32979 36512 39250 NZ_LT591897 2347 2348 6724 11100 15476 19852 24228 28604 32980 36513 39251 NZ_LT591897 2348 2349 6725 11101 15477 19853 24229 28605 32981 36514 39252 NZ_LT591897 2349 2350 6726 11102 15478 19854 24230 28606 32982 36515 NZ_LT591897 2350 2351 6727 11103 15479 19855 24231 28607 32983 36516 39253 NZ_LT591897 2351 2352 6728 11104 15480 19856 24232 28608 32984 36517 39254 NZ_LT591897 2352 2353 6729 11105 15481 19857 24233 28609 32985 39255 NZ_LT591897 2353 2354 6730 11106 15482 19858 24234 28610 32986 39256 NZ_LT591897 2354 2355 6731 11107 15483 19859 24235 28611 32987 36518 NZ_LT591897 2355 2356 6732 11108 15484 19860 24236 28612 32988 36519 39257 NZ_LT591897 2356 2357 6733 11109 15485 19861 24237 28613 32989 36520 NZ_LT591897 2357 2358 6734 11110 15486 19862 24238 28614 32990 39258 NZ_LT591897 2358 2359 6735 11111 15487 19863 24239 28615 32991 36521 NZ_LT591897 2359 2360 6736 11112 15488 19864 24240 28616 32992 36522 NZ_LT591897 2360 2361 6737 11113 15489 19865 24241 28617 32993 36523 39259 NZ_LT591897 2361 2362 6738 11114 15490 19866 24242 28618 32994 36524 39260 NZ_LT591897 2362 2363 6739 11115 15491 19867 24243 28619 32995 36525 NZ_LT591897 2363 2364 6740 11116 15492 19868 24244 28620 32996 36526 NZ_LT591897 2364 2365 6741 11117 15493 19869 24245 28621 32997 39261 NZ_LT591897 2365 2366 6742 11118 15494 19870 24246 28622 32998 36527 NZ_LT591897 2366 2367 6743 11119 15495 19871 24247 28623 32999 36528 39262 NZ_LT591897 2367 2368 6744 11120 15496 19872 24248 28624 33000 36529 NZ_LT591897 2368 2369 6745 11121 15497 19873 24249 28625 33001 36530 NZ_LT591897 2369 2370 6746 11122 15498 19874 24250 28626 33002 36531 39263 NZ_LT591897 2370 2371 6747 11123 15499 19875 24251 28627 33003 36532 NZ_LT591897 2371 2372 6748 11124 15500 19876 24252 28628 33004 39264 NZ_LT591897 2372 2373 6749 11125 15501 19877 24253 28629 33005 36533 39265 NZ_LT591897 2373 2374 6750 11126 15502 19878 24254 28630 33006 36534 NZ_LT591897 2374 2375 6751 11127 15503 19879 24255 28631 33007 36535 39266 NZ_LT591897 2375 2376 6752 11128 15504 19880 24256 28632 33008 36536 39267 NZ_LT591897 2376 2377 6753 11129 15505 19881 24257 28633 33009 36537 39268 NZ_LT591897 2377 2378 6754 11130 15506 19882 24258 28634 33010 36538 NZ_LT591897 2378 2379 6755 11131 15507 19883 24259 28635 33011 39269 NZ_LT591897 2379 2380 6756 11132 15508 19884 24260 28636 33012 39270 NZ_LT591897 2380 2381 6757 11133 15509 19885 24261 28637 33013 36539 39271 NZ_LT591897 2381 2382 6758 11134 15510 19886 24262 28638 33014 36540 NZ_LT591897 2382 2383 6759 11135 15511 19887 24263 28639 33015 36541 39272 NZ_LT591897 2383 2384 6760 11136 15512 19888 24264 28640 33016 36542 39273 NZ_LT591897 2384 2385 6761 11137 15513 19889 24265 28641 33017 36543 NZ_LT591897 2385 2386 6762 11138 15514 19890 24266 28642 33018 36544 NZ_LT591897 2386 2387 6763 11139 15515 19891 24267 28643 33019 36545 39274 NZ_LT591897 2387 2388 6764 11140 15516 19892 24268 28644 33020 36546 NZ_LT591897 2388 2389 6765 11141 15517 19893 24269 28645 33021 36547 39275 NZ_LT591897 2389 2390 6766 11142 15518 19894 24270 28646 33022 36548 NZ_LT591897 2390 2391 6767 11143 15519 19895 24271 28647 33023 36549 NZ_LT591897 2391 2392 6768 11144 15520 19896 24272 28648 33024 36550 39276 NZ_LT591897 2392 2393 6769 11145 15521 19897 24273 28649 33025 39277 NZ_LT591897 2393 2394 6770 11146 15522 19898 24274 28650 33026 39278 NZ_LT591897 2394 2395 6771 11147 15523 19899 24275 28651 33027 36551 39279 NZ_LT591897 2395 2396 6772 11148 15524 19900 24276 28652 33028 39280 NZ_LT591897 2396 2397 6773 11149 15525 19901 24277 28653 33029 36552 NZ_LT591897 2397 2398 6774 11150 15526 19902 24278 28654 33030 36553 NZ_LT591897 2398 2399 6775 11151 15527 19903 24279 28655 33031 36554 NZ_LT591897 2399 2400 6776 11152 15528 19904 24280 28656 33032 36555 NZ_LT591897 2400 2401 6777 11153 15529 19905 24281 28657 33033 39281 NZ_LT591897 2401 2402 6778 11154 15530 19906 24282 28658 33034 36556 NZ_LT591897 2402 2403 6779 11155 15531 19907 24283 28659 33035 36557 NZ_LT591897 2403 2404 6780 11156 15532 19908 24284 28660 33036 36558 NZ_LT591897 2404 2405 6781 11157 15533 19909 24285 28661 33037 39282 NZ_LT591897 2405 2406 6782 11158 15534 19910 24286 28662 33038 36559 NZ_LT591897 2406 2407 6783 11159 15535 19911 24287 28663 33039 36560 39283 NZ_LT591897 2407 2408 6784 11160 15536 19912 24288 28664 33040 39284 NZ_LT591897 2408 2409 6785 11161 15537 19913 24289 28665 33041 36561 NZ_LT591897 2409 2410 6786 11162 15538 19914 24290 28666 33042 39285 NZ_LT591897 2410 2411 6787 11163 15539 19915 24291 28667 33043 36562 39286 NZ_LT591897 2411 2412 6788 11164 15540 19916 24292 28668 33044 36563 NZ_LT591897 2412 2413 6789 11165 15541 19917 24293 28669 33045 36564 39287 NZ_LT591897 2413 2414 6790 11166 15542 19918 24294 28670 33046 39288 NZ_LT591897 2414 2415 6791 11167 15543 19919 24295 28671 33047 39289 NZ_LT591897 2415 2416 6792 11168 15544 19920 24296 28672 33048 39290 NZ_LT591897 2416 2417 6793 11169 15545 19921 24297 28673 33049 36565 NZ_LT591897 2417 2418 6794 11170 15546 19922 24298 28674 33050 36566 NZ_LT591897 2418 2419 6795 11171 15547 19923 24299 28675 33051 36567 39291 NZ_LT591897 2419 2420 6796 11172 15548 19924 24300 28676 33052 36568 39292 NZ_LT591897 2420 2421 6797 11173 15549 19925 24301 28677 33053 36569 NZ_LT591897 2421 2422 6798 11174 15550 19926 24302 28678 33054 36570 39293 NZ_LT591897 2422 2423 6799 11175 15551 19927 24303 28679 33055 36571 39294 NZ_LT591897 2423 2424 6800 11176 15552 19928 24304 28680 33056 36572 39295 NZ_LT591897 2424 2425 6801 11177 15553 19929 24305 28681 33057 36573 NZ_LT591897 2425 2426 6802 11178 15554 19930 24306 28682 33058 36574 39296 NZ_LT591897 2426 2427 6803 11179 15555 19931 24307 28683 33059 36575 NZ_LT591897 2427 2428 6804 11180 15556 19932 24308 28684 33060 36576 NZ_LT591897 2428 2429 6805 11181 15557 19933 24309 28685 33061 36577 NZ_LT591897 2429 2430 6806 11182 15558 19934 24310 28686 33062 36578 39297 NZ_LT591897 2430 2431 6807 11183 15559 19935 24311 28687 33063 36579 NZ_LT591897 2431 2432 6808 11184 15560 19936 24312 28688 33064 36580 39298 NZ_LT591897 2432 2433 6809 11185 15561 19937 24313 28689 33065 36581 39299 NZ_LT591897 2433 2434 6810 11186 15562 19938 24314 28690 33066 39300 NZ_LT591897 2434 2435 6811 11187 15563 19939 24315 28691 33067 36582 39301 NZ_LT591897 2435 2436 6812 11188 15564 19940 24316 28692 33068 39302 NZ_LT591897 2436 2437 6813 11189 15565 19941 24317 28693 33069 36583 NZ_LT591897 2437 2438 6814 11190 15566 19942 24318 28694 33070 36584 39303 NZ_LT591897 2438 2439 6815 11191 15567 19943 24319 28695 33071 36585 NZ_LT591897 2439 2440 6816 11192 15568 19944 24320 28696 33072 36586 NZ_LT591897 2440 2441 6817 11193 15569 19945 24321 28697 33073 36587 NZ_LT591897 2441 2442 6818 11194 15570 19946 24322 28698 33074 36588 NZ_LT591897 2442 2443 6819 11195 15571 19947 24323 28699 33075 36589 NZ_LT591897 2443 2444 6820 11196 15572 19948 24324 28700 33076 36590 NZ_LT591897 2444 2445 6821 11197 15573 19949 24325 28701 33077 36591 NZ_LT591897 2445 2446 6822 11198 15574 19950 24326 28702 33078 36592 39304 NZ_LT591897 2446 2447 6823 11199 15575 19951 24327 28703 33079 39305 NZ_LT591897 2447 2448 6824 11200 15576 19952 24328 28704 33080 36593 NZ_LT591897 2448 2449 6825 11201 15577 19953 24329 28705 33081 39306 NZ_LT591897 2449 2450 6826 11202 15578 19954 24330 28706 33082 36594 39307 NZ_LT591897 2450 2451 6827 11203 15579 19955 24331 28707 33083 36595 39308 NZ_LT591897 2451 2452 6828 11204 15580 19956 24332 28708 33084 39309 NZ_LT591897 2452 2453 6829 11205 15581 19957 24333 28709 33085 36596 39310 NZ_LT591897 2453 2454 6830 11206 15582 19958 24334 28710 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2789 7165 11541 15917 20293 24669 29045 33421 39545 NZ_LT591897 2789 2790 7166 11542 15918 20294 24670 29046 33422 39546 NZ_LT591897 2790 2791 7167 11543 15919 20295 24671 29047 33423 36838 39547 NZ_LT591897 2791 2792 7168 11544 15920 20296 24672 29048 33424 36839 39548 NZ_LT591897 2792 2793 7169 11545 15921 20297 24673 29049 33425 36840 NZ_LT591897 2793 2794 7170 11546 15922 20298 24674 29050 33426 39549 NZ_LT591897 2794 2795 7171 11547 15923 20299 24675 29051 33427 36841 39550 NZ_LT591897 2795 2796 7172 11548 15924 20300 24676 29052 33428 36842 NZ_LT591897 2796 2797 7173 11549 15925 20301 24677 29053 33429 36843 NZ_LT591897 2797 2798 7174 11550 15926 20302 24678 29054 33430 36844 NZ_LT591897 2798 2799 7175 11551 15927 20303 24679 29055 33431 39551 NZ_LT591897 2799 2800 7176 11552 15928 20304 24680 29056 33432 36845 39552 NZ_LT591897 2800 2801 7177 11553 15929 20305 24681 29057 33433 36846 NZ_LT591897 2801 2802 7178 11554 15930 20306 24682 29058 33434 39553 NZ_LT591897 2802 2803 7179 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11583 15959 20335 24711 29087 33463 39577 NZ_LT591897 2831 2832 7208 11584 15960 20336 24712 29088 33464 39578 NZ_LT591897 2832 2833 7209 11585 15961 20337 24713 29089 33465 39579 NZ_LT591897 2833 2834 7210 11586 15962 20338 24714 29090 33466 36862 39580 NZ_LT591897 2834 2835 7211 11587 15963 20339 24715 29091 33467 36863 NZ_LT591897 2835 2836 7212 11588 15964 20340 24716 29092 33468 36864 39581 NZ_LT591897 2836 2837 7213 11589 15965 20341 24717 29093 33469 36865 39582 NZ_LT591897 2837 2838 7214 11590 15966 20342 24718 29094 33470 36866 NZ_LT591897 2838 2839 7215 11591 15967 20343 24719 29095 33471 39583 NZ_LT591897 2839 2840 7216 11592 15968 20344 24720 29096 33472 36867 NZ_LT591897 2840 2841 7217 11593 15969 20345 24721 29097 33473 36868 39584 NZ_LT591897 2841 2842 7218 11594 15970 20346 24722 29098 33474 39585 NZ_LT591897 2842 2843 7219 11595 15971 20347 24723 29099 33475 36869 NZ_LT591897 2843 2844 7220 11596 15972 20348 24724 29100 33476 36870 39586 NZ_LT591897 2844 2845 7221 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2859 7235 11611 15987 20363 24739 29115 33491 36882 39597 NZ_LT591897 2859 2860 7236 11612 15988 20364 24740 29116 33492 36883 39598 NZ_LT591897 2860 2861 7237 11613 15989 20365 24741 29117 33493 39599 NZ_LT591897 2861 2862 7238 11614 15990 20366 24742 29118 33494 36884 39600 NZ_LT591897 2862 2863 7239 11615 15991 20367 24743 29119 33495 36885 39601 NZ_LT591897 2863 2864 7240 11616 15992 20368 24744 29120 33496 36886 39602 NZ_LT591897 2864 2865 7241 11617 15993 20369 24745 29121 33497 39603 NZ_LT591897 2865 2866 7242 11618 15994 20370 24746 29122 33498 36887 NZ_LT591897 2866 2867 7243 11619 15995 20371 24747 29123 33499 36888 NZ_LT591897 2867 2868 7244 11620 15996 20372 24748 29124 33500 36889 39604 NZ_LT591897 2868 2869 7245 11621 15997 20373 24749 29125 33501 36890 NZ_LT591897 2869 2870 7246 11622 15998 20374 24750 29126 33502 36891 39605 NZ_LT591897 2870 2871 7247 11623 15999 20375 24751 29127 33503 39606 NZ_LT591897 2871 2872 7248 11624 16000 20376 24752 29128 33504 36892 NZ_LT591897 2872 2873 7249 11625 16001 20377 24753 29129 33505 36893 39607 NZ_LT591897 2873 2874 7250 11626 16002 20378 24754 29130 33506 36894 NZ_LT591897 2874 2875 7251 11627 16003 20379 24755 29131 33507 36895 39608 NZ_LT591897 2875 2876 7252 11628 16004 20380 24756 29132 33508 36896 NZ_LT591897 2876 2877 7253 11629 16005 20381 24757 29133 33509 36897 NZ_LT591897 2877 2878 7254 11630 16006 20382 24758 29134 33510 36898 NZ_LT591897 2878 2879 7255 11631 16007 20383 24759 29135 33511 36899 NZ_LT591897 2879 2880 7256 11632 16008 20384 24760 29136 33512 36900 39609 NZ_LT591897 2880 2881 7257 11633 16009 20385 24761 29137 33513 36901 39610 NZ_LT591897 2881 2882 7258 11634 16010 20386 24762 29138 33514 36902 NZ_LT591897 2882 2883 7259 11635 16011 20387 24763 29139 33515 36903 39611 NZ_LT591897 2883 2884 7260 11636 16012 20388 24764 29140 33516 36904 39612 NZ_LT591897 2884 2885 7261 11637 16013 20389 24765 29141 33517 36905 39613 NZ_LT591897 2885 2886 7262 11638 16014 20390 24766 29142 33518 36906 NZ_LT591897 2886 2887 7263 11639 16015 20391 24767 29143 33519 36907 39614 NZ_LT591897 2887 2888 7264 11640 16016 20392 24768 29144 33520 39615 NZ_LT591897 2888 2889 7265 11641 16017 20393 24769 29145 33521 39616 NZ_LT591897 2889 2890 7266 11642 16018 20394 24770 29146 33522 36908 39617 NZ_LT591897 2890 2891 7267 11643 16019 20395 24771 29147 33523 39618 NZ_LT591897 2891 2892 7268 11644 16020 20396 24772 29148 33524 39619 NZ_LT591897 2892 2893 7269 11645 16021 20397 24773 29149 33525 39620 NZ_LT591897 2893 2894 7270 11646 16022 20398 24774 29150 33526 39621 NZ_LT591897 2894 2895 7271 11647 16023 20399 24775 29151 33527 36909 NZ_LT591897 2895 2896 7272 11648 16024 20400 24776 29152 33528 36910 NZ_LT591897 2896 2897 7273 11649 16025 20401 24777 29153 33529 36911 39622 NZ_LT591897 2897 2898 7274 11650 16026 20402 24778 29154 33530 36912 39623 NZ_LT591897 2898 2899 7275 11651 16027 20403 24779 29155 33531 36913 39624 NZ_LT591897 2899 2900 7276 11652 16028 20404 24780 29156 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24794 29170 33546 36924 39636 NZ_LT591897 2914 2915 7291 11667 16043 20419 24795 29171 33547 36925 NZ_LT591897 2915 2916 7292 11668 16044 20420 24796 29172 33548 36926 39637 NZ_LT591897 2916 2917 7293 11669 16045 20421 24797 29173 33549 36927 NZ_LT591897 2917 2918 7294 11670 16046 20422 24798 29174 33550 36928 39638 NZ_LT591897 2918 2919 7295 11671 16047 20423 24799 29175 33551 39639 NZ_LT591897 2919 2920 7296 11672 16048 20424 24800 29176 33552 39640 NZ_LT591897 2920 2921 7297 11673 16049 20425 24801 29177 33553 36929 NZ_LT591897 2921 2922 7298 11674 16050 20426 24802 29178 33554 36930 NZ_LT591897 2922 2923 7299 11675 16051 20427 24803 29179 33555 39641 NZ_LT591897 2923 2924 7300 11676 16052 20428 24804 29180 33556 36931 NZ_LT591897 2924 2925 7301 11677 16053 20429 24805 29181 33557 36932 NZ_LT591897 2925 2926 7302 11678 16054 20430 24806 29182 33558 36933 NZ_LT591897 2926 2927 7303 11679 16055 20431 24807 29183 33559 36934 NZ_LT591897 2927 2928 7304 11680 16056 20432 24808 29184 33560 36935 39642 NZ_LT591897 2928 2929 7305 11681 16057 20433 24809 29185 33561 36936 NZ_LT591897 2929 2930 7306 11682 16058 20434 24810 29186 33562 39643 NZ_LT591897 2930 2931 7307 11683 16059 20435 24811 29187 33563 36937 NZ_LT591897 2931 2932 7308 11684 16060 20436 24812 29188 33564 39644 NZ_LT591897 2932 2933 7309 11685 16061 20437 24813 29189 33565 36938 NZ_LT591897 2933 2934 7310 11686 16062 20438 24814 29190 33566 39645 NZ_LT591897 2934 2935 7311 11687 16063 20439 24815 29191 33567 36939 39646 NZ_LT591897 2935 2936 7312 11688 16064 20440 24816 29192 33568 36940 39647 NZ_LT591897 2936 2937 7313 11689 16065 20441 24817 29193 33569 36941 NZ_LT591897 2937 2938 7314 11690 16066 20442 24818 29194 33570 36942 39648 NZ_LT591897 2938 2939 7315 11691 16067 20443 24819 29195 33571 36943 39649 NZ_LT591897 2939 2940 7316 11692 16068 20444 24820 29196 33572 36944 39650 NZ_LT591897 2940 2941 7317 11693 16069 20445 24821 29197 33573 36945 39651 NZ_LT591897 2941 2942 7318 11694 16070 20446 24822 29198 33574 36946 39652 NZ_LT591897 2942 2943 7319 11695 16071 20447 24823 29199 33575 36947 39653 NZ_LT591897 2943 2944 7320 11696 16072 20448 24824 29200 33576 36948 39654 NZ_LT591897 2944 2945 7321 11697 16073 20449 24825 29201 33577 36949 39655 NZ_LT591897 2945 2946 7322 11698 16074 20450 24826 29202 33578 39656 NZ_LT591897 2946 2947 7323 11699 16075 20451 24827 29203 33579 36950 NZ_LT591897 2947 2948 7324 11700 16076 20452 24828 29204 33580 39657 NZ_LT591897 2948 2949 7325 11701 16077 20453 24829 29205 33581 36951 NZ_LT591897 2949 2950 7326 11702 16078 20454 24830 29206 33582 39658 NZ_LT591897 2950 2951 7327 11703 16079 20455 24831 29207 33583 36952 39659 NZ_LT591897 2951 2952 7328 11704 16080 20456 24832 29208 33584 36953 39660 NZ_LT591897 2952 2953 7329 11705 16081 20457 24833 29209 33585 36954 NZ_LT591897 2953 2954 7330 11706 16082 20458 24834 29210 33586 36955 39661 NZ_LT591897 2954 2955 7331 11707 16083 20459 24835 29211 33587 36956 39662 NZ_LT591897 2955 2956 7332 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29267 33643 39703 NZ_LT591897 3011 3012 7388 11764 16140 20516 24892 29268 33644 37000 NZ_LT591897 3012 3013 7389 11765 16141 20517 24893 29269 33645 37001 NZ_LT591897 3013 3014 7390 11766 16142 20518 24894 29270 33646 39704 NZ_LT591897 3014 3015 7391 11767 16143 20519 24895 29271 33647 39705 NZ_LT591897 3015 3016 7392 11768 16144 20520 24896 29272 33648 39706 NZ_LT591897 3016 3017 7393 11769 16145 20521 24897 29273 33649 37002 NZ_LT591897 3017 3018 7394 11770 16146 20522 24898 29274 33650 37003 NZ_LT591897 3018 3019 7395 11771 16147 20523 24899 29275 33651 37004 39707 NZ_LT591897 3019 3020 7396 11772 16148 20524 24900 29276 33652 39708 NZ_LT591897 3020 3021 7397 11773 16149 20525 24901 29277 33653 37005 NZ_LT591897 3021 3022 7398 11774 16150 20526 24902 29278 33654 37006 NZ_LT591897 3022 3023 7399 11775 16151 20527 24903 29279 33655 37007 NZ_LT591897 3023 3024 7400 11776 16152 20528 24904 29280 33656 37008 39709 NZ_LT591897 3024 3025 7401 11777 16153 20529 24905 29281 33657 37009 39710 NZ_LT591897 3025 3026 7402 11778 16154 20530 24906 29282 33658 37010 39711 NZ_LT591897 3026 3027 7403 11779 16155 20531 24907 29283 33659 37011 39712 NZ_LT591897 3027 3028 7404 11780 16156 20532 24908 29284 33660 37012 NZ_LT591897 3028 3029 7405 11781 16157 20533 24909 29285 33661 39713 NZ_LT591897 3029 3030 7406 11782 16158 20534 24910 29286 33662 37013 39714 NZ_LT591897 3030 3031 7407 11783 16159 20535 24911 29287 33663 39715 NZ_LT591897 3031 3032 7408 11784 16160 20536 24912 29288 33664 39716 NZ_LT591897 3032 3033 7409 11785 16161 20537 24913 29289 33665 37014 39717 NZ_LT591897 3033 3034 7410 11786 16162 20538 24914 29290 33666 39718 NZ_LT591897 3034 3035 7411 11787 16163 20539 24915 29291 33667 37015 NZ_LT591897 3035 3036 7412 11788 16164 20540 24916 29292 33668 37016 39719 NZ_LT591897 3036 3037 7413 11789 16165 20541 24917 29293 33669 37017 39720 NZ_LT591897 3037 3038 7414 11790 16166 20542 24918 29294 33670 37018 39721 NZ_LT591897 3038 3039 7415 11791 16167 20543 24919 29295 33671 37019 39722 NZ_LT591897 3039 3040 7416 11792 16168 20544 24920 29296 33672 37020 NZ_LT591897 3040 3041 7417 11793 16169 20545 24921 29297 33673 37021 NZ_LT591897 3041 3042 7418 11794 16170 20546 24922 29298 33674 37022 39723 NZ_LT591897 3042 3043 7419 11795 16171 20547 24923 29299 33675 37023 39724 NZ_LT591897 3043 3044 7420 11796 16172 20548 24924 29300 33676 39725 NZ_LT591897 3044 3045 7421 11797 16173 20549 24925 29301 33677 37024 NZ_LT591897 3045 3046 7422 11798 16174 20550 24926 29302 33678 37025 NZ_LT591897 3046 3047 7423 11799 16175 20551 24927 29303 33679 37026 39726 NZ_LT591897 3047 3048 7424 11800 16176 20552 24928 29304 33680 39727 NZ_LT591897 3048 3049 7425 11801 16177 20553 24929 29305 33681 37027 NZ_LT591897 3049 3050 7426 11802 16178 20554 24930 29306 33682 39728 NZ_LT591897 3050 3051 7427 11803 16179 20555 24931 29307 33683 37028 NZ_LT591897 3051 3052 7428 11804 16180 20556 24932 29308 33684 37029 39729 NZ_LT591897 3052 3053 7429 11805 16181 20557 24933 29309 33685 39730 NZ_LT591897 3053 3054 7430 11806 16182 20558 24934 29310 33686 39731 NZ_LT591897 3054 3055 7431 11807 16183 20559 24935 29311 33687 37030 NZ_LT591897 3055 3056 7432 11808 16184 20560 24936 29312 33688 37031 NZ_LT591897 3056 3057 7433 11809 16185 20561 24937 29313 33689 37032 39732 NZ_LT591897 3057 3058 7434 11810 16186 20562 24938 29314 33690 39733 NZ_LT591897 3058 3059 7435 11811 16187 20563 24939 29315 33691 37033 NZ_LT591897 3059 3060 7436 11812 16188 20564 24940 29316 33692 39734 NZ_LT591897 3060 3061 7437 11813 16189 20565 24941 29317 33693 37034 NZ_LT591897 3061 3062 7438 11814 16190 20566 24942 29318 33694 37035 39735 NZ_LT591897 3062 3063 7439 11815 16191 20567 24943 29319 33695 37036 39736 NZ_LT591897 3063 3064 7440 11816 16192 20568 24944 29320 33696 37037 NZ_LT591897 3064 3065 7441 11817 16193 20569 24945 29321 33697 37038 NZ_LT591897 3065 3066 7442 11818 16194 20570 24946 29322 33698 37039 39737 NZ_LT591897 3066 3067 7443 11819 16195 20571 24947 29323 33699 37040 39738 NZ_LT591897 3067 3068 7444 11820 16196 20572 24948 29324 33700 37041 NZ_LT591897 3068 3069 7445 11821 16197 20573 24949 29325 33701 37042 39739 NZ_LT591897 3069 3070 7446 11822 16198 20574 24950 29326 33702 37043 39740 NZ_LT591897 3070 3071 7447 11823 16199 20575 24951 29327 33703 37044 NZ_LT591897 3071 3072 7448 11824 16200 20576 24952 29328 33704 37045 39741 NZ_LT591897 3072 3073 7449 11825 16201 20577 24953 29329 33705 37046 39742 NZ_LT591897 3073 3074 7450 11826 16202 20578 24954 29330 33706 37047 39743 NZ_LT591897 3074 3075 7451 11827 16203 20579 24955 29331 33707 37048 39744 NZ_LT591897 3075 3076 7452 11828 16204 20580 24956 29332 33708 37049 NZ_LT591897 3076 3077 7453 11829 16205 20581 24957 29333 33709 39745 NZ_LT591897 3077 3078 7454 11830 16206 20582 24958 29334 33710 37050 NZ_LT591897 3078 3079 7455 11831 16207 20583 24959 29335 33711 37051 NZ_LT591897 3079 3080 7456 11832 16208 20584 24960 29336 33712 37052 39746 NZ_LT591897 3080 3081 7457 11833 16209 20585 24961 29337 33713 39747 NZ_LT591897 3081 3082 7458 11834 16210 20586 24962 29338 33714 39748 NZ_LT591897 3082 3083 7459 11835 16211 20587 24963 29339 33715 37053 39749 NZ_LT591897 3083 3084 7460 11836 16212 20588 24964 29340 33716 39750 NZ_LT591897 3084 3085 7461 11837 16213 20589 24965 29341 33717 37054 NZ_LT591897 3085 3086 7462 11838 16214 20590 24966 29342 33718 37055 NZ_LT591897 3086 3087 7463 11839 16215 20591 24967 29343 33719 37056 39751 NZ_LT591897 3087 3088 7464 11840 16216 20592 24968 29344 33720 39752 NZ_LT591897 3088 3089 7465 11841 16217 20593 24969 29345 33721 39753 NZ_LT591897 3089 3090 7466 11842 16218 20594 24970 29346 33722 39754 NZ_LT591897 3090 3091 7467 11843 16219 20595 24971 29347 33723 37057 39755 NZ_LT591897 3091 3092 7468 11844 16220 20596 24972 29348 33724 37058 39756 NZ_LT591897 3092 3093 7469 11845 16221 20597 24973 29349 33725 39757 NZ_LT591897 3093 3094 7470 11846 16222 20598 24974 29350 33726 37059 NZ_LT591897 3094 3095 7471 11847 16223 20599 24975 29351 33727 37060 39758 NZ_LT591897 3095 3096 7472 11848 16224 20600 24976 29352 33728 39759 NZ_LT591897 3096 3097 7473 11849 16225 20601 24977 29353 33729 37061 39760 NZ_LT591897 3097 3098 7474 11850 16226 20602 24978 29354 33730 37062 39761 NZ_LT591897 3098 3099 7475 11851 16227 20603 24979 29355 33731 37063 39762 NZ_LT591897 3099 3100 7476 11852 16228 20604 24980 29356 33732 37064 NZ_LT591897 3100 3101 7477 11853 16229 20605 24981 29357 33733 37065 39763 NZ_LT591897 3101 3102 7478 11854 16230 20606 24982 29358 33734 37066 39764 NZ_LT591897 3102 3103 7479 11855 16231 20607 24983 29359 33735 37067 NZ_LT591897 3103 3104 7480 11856 16232 20608 24984 29360 33736 39765 NZ_LT591897 3104 3105 7481 11857 16233 20609 24985 29361 33737 37068 39766 NZ_LT591897 3105 3106 7482 11858 16234 20610 24986 29362 33738 39767 NZ_LT591897 3106 3107 7483 11859 16235 20611 24987 29363 33739 39768 NZ_LT591897 3107 3108 7484 11860 16236 20612 24988 29364 33740 39769 NZ_LT591897 3108 3109 7485 11861 16237 20613 24989 29365 33741 37069 NZ_LT591897 3109 3110 7486 11862 16238 20614 24990 29366 33742 37070 NZ_LT591897 3110 3111 7487 11863 16239 20615 24991 29367 33743 39770 NZ_LT591897 3111 3112 7488 11864 16240 20616 24992 29368 33744 37071 NZ_LT591897 3112 3113 7489 11865 16241 20617 24993 29369 33745 39771 NZ_LT591897 3113 3114 7490 11866 16242 20618 24994 29370 33746 37072 39772 NZ_LT591897 3114 3115 7491 11867 16243 20619 24995 29371 33747 37073 NZ_LT591897 3115 3116 7492 11868 16244 20620 24996 29372 33748 39773 NZ_LT591897 3116 3117 7493 11869 16245 20621 24997 29373 33749 37074 NZ_LT591897 3117 3118 7494 11870 16246 20622 24998 29374 33750 37075 39774 NZ_LT591897 3118 3119 7495 11871 16247 20623 24999 29375 33751 37076 NZ_LT591897 3119 3120 7496 11872 16248 20624 25000 29376 33752 37077 NZ_LT591897 3120 3121 7497 11873 16249 20625 25001 29377 33753 37078 NZ_LT591897 3121 3122 7498 11874 16250 20626 25002 29378 33754 39775 NZ_LT591897 3122 3123 7499 11875 16251 20627 25003 29379 33755 37079 39776 NZ_LT591897 3123 3124 7500 11876 16252 20628 25004 29380 33756 37080 39777 NZ_LT591897 3124 3125 7501 11877 16253 20629 25005 29381 33757 39778 NZ_LT591897 3125 3126 7502 11878 16254 20630 25006 29382 33758 39779 NZ_LT591897 3126 3127 7503 11879 16255 20631 25007 29383 33759 37081 39780 NZ_LT591897 3127 3128 7504 11880 16256 20632 25008 29384 33760 37082 NZ_LT591897 3128 3129 7505 11881 16257 20633 25009 29385 33761 37083 NZ_LT591897 3129 3130 7506 11882 16258 20634 25010 29386 33762 37084 39781 NZ_LT591897 3130 3131 7507 11883 16259 20635 25011 29387 33763 39782 NZ_LT591897 3131 3132 7508 11884 16260 20636 25012 29388 33764 37085 39783 NZ_LT591897 3132 3133 7509 11885 16261 20637 25013 29389 33765 37086 NZ_LT591897 3133 3134 7510 11886 16262 20638 25014 29390 33766 39784 NZ_LT591897 3134 3135 7511 11887 16263 20639 25015 29391 33767 37087 39785 NZ_LT591897 3135 3136 7512 11888 16264 20640 25016 29392 33768 37088 39786 NZ_LT591897 3136 3137 7513 11889 16265 20641 25017 29393 33769 37089 39787 NZ_LT591897 3137 3138 7514 11890 16266 20642 25018 29394 33770 37090 39788 NZ_LT591897 3138 3139 7515 11891 16267 20643 25019 29395 33771 37091 39789 NZ_LT591897 3139 3140 7516 11892 16268 20644 25020 29396 33772 37092 NZ_LT591897 3140 3141 7517 11893 16269 20645 25021 29397 33773 37093 NZ_LT591897 3141 3142 7518 11894 16270 20646 25022 29398 33774 37094 39790 NZ_LT591897 3142 3143 7519 11895 16271 20647 25023 29399 33775 37095 NZ_LT591897 3143 3144 7520 11896 16272 20648 25024 29400 33776 37096 NZ_LT591897 3144 3145 7521 11897 16273 20649 25025 29401 33777 37097 NZ_LT591897 3145 3146 7522 11898 16274 20650 25026 29402 33778 37098 39791 NZ_LT591897 3146 3147 7523 11899 16275 20651 25027 29403 33779 37099 39792 NZ_LT591897 3147 3148 7524 11900 16276 20652 25028 29404 33780 39793 NZ_LT591897 3148 3149 7525 11901 16277 20653 25029 29405 33781 37100 NZ_LT591897 3149 3150 7526 11902 16278 20654 25030 29406 33782 39794 NZ_LT591897 3150 3151 7527 11903 16279 20655 25031 29407 33783 37101 NZ_LT591897 3151 3152 7528 11904 16280 20656 25032 29408 33784 39795 NZ_LT591897 3152 3153 7529 11905 16281 20657 25033 29409 33785 37102 39796 NZ_LT591897 3153 3154 7530 11906 16282 20658 25034 29410 33786 37103 39797 NZ_LT591897 3154 3155 7531 11907 16283 20659 25035 29411 33787 39798 NZ_LT591897 3155 3156 7532 11908 16284 20660 25036 29412 33788 39799 NZ_LT591897 3156 3157 7533 11909 16285 20661 25037 29413 33789 37104 NZ_LT591897 3157 3158 7534 11910 16286 20662 25038 29414 33790 39800 NZ_LT591897 3158 3159 7535 11911 16287 20663 25039 29415 33791 39801 NZ_LT591897 3159 3160 7536 11912 16288 20664 25040 29416 33792 37105 39802 NZ_LT591897 3160 3161 7537 11913 16289 20665 25041 29417 33793 37106 39803 NZ_LT591897 3161 3162 7538 11914 16290 20666 25042 29418 33794 37107 NZ_LT591897 3162 3163 7539 11915 16291 20667 25043 29419 33795 39804 NZ_LT591897 3163 3164 7540 11916 16292 20668 25044 29420 33796 39805 NZ_LT591897 3164 3165 7541 11917 16293 20669 25045 29421 33797 37108 39806 NZ_LT591897 3165 3166 7542 11918 16294 20670 25046 29422 33798 37109 39807 NZ_LT591897 3166 3167 7543 11919 16295 20671 25047 29423 33799 39808 NZ_LT591897 3167 3168 7544 11920 16296 20672 25048 29424 33800 37110 NZ_LT591897 3168 3169 7545 11921 16297 20673 25049 29425 33801 37111 39809 NZ_LT591897 3169 3170 7546 11922 16298 20674 25050 29426 33802 39810 NZ_LT591897 3170 3171 7547 11923 16299 20675 25051 29427 33803 37112 NZ_LT591897 3171 3172 7548 11924 16300 20676 25052 29428 33804 37113 39811 NZ_LT591897 3172 3173 7549 11925 16301 20677 25053 29429 33805 37114 39812 NZ_LT591897 3173 3174 7550 11926 16302 20678 25054 29430 33806 37115 39813 NZ_LT591897 3174 3175 7551 11927 16303 20679 25055 29431 33807 39814 NZ_LT591897 3175 3176 7552 11928 16304 20680 25056 29432 33808 37116 39815 NZ_LT591897 3176 3177 7553 11929 16305 20681 25057 29433 33809 37117 39816 NZ_LT591897 3177 3178 7554 11930 16306 20682 25058 29434 33810 37118 NZ_LT591897 3178 3179 7555 11931 16307 20683 25059 29435 33811 37119 39817 NZ_LT591897 3179 3180 7556 11932 16308 20684 25060 29436 33812 37120 39818 NZ_LT591897 3180 3181 7557 11933 16309 20685 25061 29437 33813 37121 39819 NZ_LT591897 3181 3182 7558 11934 16310 20686 25062 29438 33814 39820 NZ_LT591897 3182 3183 7559 11935 16311 20687 25063 29439 33815 37122 39821 NZ_LT591897 3183 3184 7560 11936 16312 20688 25064 29440 33816 37123 39822 NZ_LT591897 3184 3185 7561 11937 16313 20689 25065 29441 33817 39823 NZ_LT591897 3185 3186 7562 11938 16314 20690 25066 29442 33818 37124 39824 NZ_LT591897 3186 3187 7563 11939 16315 20691 25067 29443 33819 37125 39825 NZ_LT591897 3187 3188 7564 11940 16316 20692 25068 29444 33820 39826 NZ_LT591897 3188 3189 7565 11941 16317 20693 25069 29445 33821 37126 NZ_LT591897 3189 3190 7566 11942 16318 20694 25070 29446 33822 39827 NZ_LT591897 3190 3191 7567 11943 16319 20695 25071 29447 33823 37127 39828 NZ_LT591897 3191 3192 7568 11944 16320 20696 25072 29448 33824 37128 39829 NZ_LT591897 3192 3193 7569 11945 16321 20697 25073 29449 33825 39830 NZ_LT591897 3193 3194 7570 11946 16322 20698 25074 29450 33826 37129 NZ_LT591897 3194 3195 7571 11947 16323 20699 25075 29451 33827 37130 NZ_LT591897 3195 3196 7572 11948 16324 20700 25076 29452 33828 39831 NZ_LT591897 3196 3197 7573 11949 16325 20701 25077 29453 33829 37131 39832 NZ_LT591897 3197 3198 7574 11950 16326 20702 25078 29454 33830 39833 NZ_LT591897 3198 3199 7575 11951 16327 20703 25079 29455 33831 37132 NZ_LT591897 3199 3200 7576 11952 16328 20704 25080 29456 33832 37133 NZ_LT591897 3200 3201 7577 11953 16329 20705 25081 29457 33833 37134 NZ_LT591897 3201 3202 7578 11954 16330 20706 25082 29458 33834 39834 NZ_LT591897 3202 3203 7579 11955 16331 20707 25083 29459 33835 37135 NZ_LT591897 3203 3204 7580 11956 16332 20708 25084 29460 33836 39835 NZ_LT591897 3204 3205 7581 11957 16333 20709 25085 29461 33837 37136 39836 NZ_LT591897 3205 3206 7582 11958 16334 20710 25086 29462 33838 39837 NZ_LT591897 3206 3207 7583 11959 16335 20711 25087 29463 33839 37137 NZ_LT591897 3207 3208 7584 11960 16336 20712 25088 29464 33840 37138 39838 NZ_LT591897 3208 3209 7585 11961 16337 20713 25089 29465 33841 39839 NZ_LT591897 3209 3210 7586 11962 16338 20714 25090 29466 33842 37139 NZ_LT591897 3210 3211 7587 11963 16339 20715 25091 29467 33843 39840 NZ_LT591897 3211 3212 7588 11964 16340 20716 25092 29468 33844 37140 NZ_LT591897 3212 3213 7589 11965 16341 20717 25093 29469 33845 37141 NZ_LT591897 3213 3214 7590 11966 16342 20718 25094 29470 33846 39841 NZ_LT591897 3214 3215 7591 11967 16343 20719 25095 29471 33847 39842 NZ_LT591897 3215 3216 7592 11968 16344 20720 25096 29472 33848 37142 39843 NZ_LT591897 3216 3217 7593 11969 16345 20721 25097 29473 33849 37143 NZ_LT591897 3217 3218 7594 11970 16346 20722 25098 29474 33850 37144 NZ_LT591897 3218 3219 7595 11971 16347 20723 25099 29475 33851 39844 NZ_LT591897 3219 3220 7596 11972 16348 20724 25100 29476 33852 37145 NZ_LT591897 3220 3221 7597 11973 16349 20725 25101 29477 33853 37146 39845 NZ_LT591897 3221 3222 7598 11974 16350 20726 25102 29478 33854 37147 39846 NZ_LT591897 3222 3223 7599 11975 16351 20727 25103 29479 33855 37148 39847 NZ_LT591897 3223 3224 7600 11976 16352 20728 25104 29480 33856 39848 NZ_LT591897 3224 3225 7601 11977 16353 20729 25105 29481 33857 37149 NZ_LT591897 3225 3226 7602 11978 16354 20730 25106 29482 33858 37150 NZ_LT591897 3226 3227 7603 11979 16355 20731 25107 29483 33859 37151 39849 NZ_LT591897 3227 3228 7604 11980 16356 20732 25108 29484 33860 37152 39850 NZ_LT591897 3228 3229 7605 11981 16357 20733 25109 29485 33861 37153 39851 NZ_LT591897 3229 3230 7606 11982 16358 20734 25110 29486 33862 37154 NZ_LT591897 3230 3231 7607 11983 16359 20735 25111 29487 33863 37155 39852 NZ_LT591897 3231 3232 7608 11984 16360 20736 25112 29488 33864 39853 NZ_LT591897 3232 3233 7609 11985 16361 20737 25113 29489 33865 37156 39854 NZ_LT591897 3233 3234 7610 11986 16362 20738 25114 29490 33866 39855 NZ_LT591897 3234 3235 7611 11987 16363 20739 25115 29491 33867 37157 39856 NZ_LT591897 3235 3236 7612 11988 16364 20740 25116 29492 33868 37158 NZ_LT591897 3236 3237 7613 11989 16365 20741 25117 29493 33869 37159 39857 NZ_LT591897 3237 3238 7614 11990 16366 20742 25118 29494 33870 37160 NZ_LT591897 3238 3239 7615 11991 16367 20743 25119 29495 33871 37161 NZ_LT591897 3239 3240 7616 11992 16368 20744 25120 29496 33872 37162 NZ_LT591897 3240 3241 7617 11993 16369 20745 25121 29497 33873 39858 NZ_LT591897 3241 3242 7618 11994 16370 20746 25122 29498 33874 39859 NZ_LT591897 3242 3243 7619 11995 16371 20747 25123 29499 33875 37163 39860 NZ_LT591897 3243 3244 7620 11996 16372 20748 25124 29500 33876 37164 NZ_LT591897 3244 3245 7621 11997 16373 20749 25125 29501 33877 37165 39861 NZ_LT591897 3245 3246 7622 11998 16374 20750 25126 29502 33878 37166 NZ_LT591897 3246 3247 7623 11999 16375 20751 25127 29503 33879 37167 NZ_LT591897 3247 3248 7624 12000 16376 20752 25128 29504 33880 39862 NZ_LT591897 3248 3249 7625 12001 16377 20753 25129 29505 33881 39863 NZ_LT591897 3249 3250 7626 12002 16378 20754 25130 29506 33882 37168 39864 NZ_LT591897 3250 3251 7627 12003 16379 20755 25131 29507 33883 37169 NZ_LT591897 3251 3252 7628 12004 16380 20756 25132 29508 33884 37170 39865 NZ_LT591897 3252 3253 7629 12005 16381 20757 25133 29509 33885 37171 NZ_LT591897 3253 3254 7630 12006 16382 20758 25134 29510 33886 37172 39866 NZ_LT591897 3254 3255 7631 12007 16383 20759 25135 29511 33887 37173 NZ_LT591897 3255 3256 7632 12008 16384 20760 25136 29512 33888 39867 NZ_LT591897 3256 3257 7633 12009 16385 20761 25137 29513 33889 37174 39868 NZ_LT591897 3257 3258 7634 12010 16386 20762 25138 29514 33890 39869 NZ_LT591897 3258 3259 7635 12011 16387 20763 25139 29515 33891 39870 NZ_LT591897 3259 3260 7636 12012 16388 20764 25140 29516 33892 39871 NZ_LT591897 3260 3261 7637 12013 16389 20765 25141 29517 33893 37175 39872 NZ_LT591897 3261 3262 7638 12014 16390 20766 25142 29518 33894 37176 NZ_LT591897 3262 3263 7639 12015 16391 20767 25143 29519 33895 39873 NZ_LT591897 3263 3264 7640 12016 16392 20768 25144 29520 33896 37177 39874 NZ_LT591897 3264 3265 7641 12017 16393 20769 25145 29521 33897 39875 NZ_LT591897 3265 3266 7642 12018 16394 20770 25146 29522 33898 37178 39876 NZ_LT591897 3266 3267 7643 12019 16395 20771 25147 29523 33899 39877 NZ_LT591897 3267 3268 7644 12020 16396 20772 25148 29524 33900 39878 NZ_LT591897 3268 3269 7645 12021 16397 20773 25149 29525 33901 39879 NC_014953 3269 3270 7646 12022 16398 20774 25150 29526 33902 39880 NC_014953 3270 3271 7647 12023 16399 20775 25151 29527 33903 37179 NC_014953 3271 3272 7648 12024 16400 20776 25152 29528 33904 37180 NC_014953 3272 3273 7649 12025 16401 20777 25153 29529 33905 37181 39881 NC_014953 3273 3274 7650 12026 16402 20778 25154 29530 33906 39882 NC_014953 3274 3275 7651 12027 16403 20779 25155 29531 33907 37182 NC_014953 3275 3276 7652 12028 16404 20780 25156 29532 33908 37183 NC_014953 3276 3277 7653 12029 16405 20781 25157 29533 33909 39883 NC_014953 3277 3278 7654 12030 16406 20782 25158 29534 33910 37184 39884 NC_014953 3278 3279 7655 12031 16407 20783 25159 29535 33911 37185 NC_014953 3279 3280 7656 12032 16408 20784 25160 29536 33912 39885 NC_014953 3280 3281 7657 12033 16409 20785 25161 29537 33913 37186 NC_014953 3281 3282 7658 12034 16410 20786 25162 29538 33914 37187 NC_014953 3282 3283 7659 12035 16411 20787 25163 29539 33915 37188 NC_007376 3283 3284 7660 12036 16412 20788 25164 29540 33916 37189 NC_007376 3284 3285 7661 12037 16413 20789 25165 29541 33917 37190 NC_007376 3285 3286 7662 12038 16414 20790 25166 29542 33918 39886 NC_007376 3286 3287 7663 12039 16415 20791 25167 29543 33919 37191 NC_007376 3287 3288 7664 12040 16416 20792 25168 29544 33920 37192 NC_007376 3288 3289 7665 12041 16417 20793 25169 29545 33921 39887 NC_007376 3289 3290 7666 12042 16418 20794 25170 29546 33922 39888 NC_001653 3290 3291 7667 12043 16419 20795 25171 29547 33923 39889 NC_001653 3291 3292 7668 12044 16420 20796 25172 29548 33924 37193 39890 NC_001653 3292 3293 7669 12045 16421 20797 25173 29549 33925 39891 NC_001653 3293 3294 7670 12046 16422 20798 25174 29550 33926 37194 NC_001653 3294 3295 7671 12047 16423 20799 25175 29551 33927 37195 39892 NC_001583 3295 3296 7672 12048 16424 20800 25176 29552 33928 39893 NC_001583 3296 3297 7673 12049 16425 20801 25177 29553 33929 39894 NC_001583 3297 3298 7674 12050 16426 20802 25178 29554 33930 39895 NC_001583 3298 3299 7675 12051 16427 20803 25179 29555 33931 37196 39896 NC_001583 3299 3300 7676 12052 16428 20804 25180 29556 33932 37197 39897 NC_001583 3300 3301 7677 12053 16429 20805 25181 29557 33933 39898 NC_001583 3301 3302 7678 12054 16430 20806 25182 29558 33934 37198 NC_001583 3302 3303 7679 12055 16431 20807 25183 29559 33935 39899 NC_001583 3303 3304 7680 12056 16432 20808 25184 29560 33936 37199 39900 NC_001583 3304 3305 7681 12057 16433 20809 25185 29561 33937 39901 NC_001583 3305 3306 7682 12058 16434 20810 25186 29562 33938 37200 39902 NC_001583 3306 3307 7683 12059 16435 20811 25187 29563 33939 37201 NC_001583 3307 3308 7684 12060 16436 20812 25188 29564 33940 39903 NC_001583 3308 3309 7685 12061 16437 20813 25189 29565 33941 39904 NC_001583 3309 3310 7686 12062 16438 20814 25190 29566 33942 37202 NC_001583 3310 3311 7687 12063 16439 20815 25191 29567 33943 39905 NC_001583 3311 3312 7688 12064 16440 20816 25192 29568 33944 37203 NC_001655 3312 3313 7689 12065 16441 20817 25193 29569 33945 37204 39906 NC_001655 3313 3314 7690 12066 16442 20818 25194 29570 33946 37205 39907 NC_001655 3314 3315 7691 12067 16443 20819 25195 29571 33947 39908 NC_001655 3315 3316 7692 12068 16444 20820 25196 29572 33948 37206 39909 NC_001655 3316 3317 7693 12069 16445 20821 25197 29573 33949 37207 39910 NC_001655 3317 3318 7694 12070 16446 20822 25198 29574 33950 39911 NC_001655 3318 3319 7695 12071 16447 20823 25199 29575 33951 37208 NC_001655 3319 3320 7696 12072 16448 20824 25200 29576 33952 37209 39912 NC_001655 3320 3321 7697 12073 16449 20825 25201 29577 33953 37210 39913 NC_001655 3321 3322 7698 12074 16450 20826 25202 29578 33954 39914 NC_001655 3322 3323 7699 12075 16451 20827 25203 29579 33955 39915 NC_001655 3323 3324 7700 12076 16452 20828 25204 29580 33956 37211 39916 NC_001655 3324 3325 7701 12077 16453 20829 25205 29581 33957 39917 NC_001655 3325 3326 7702 12078 16454 20830 25206 29582 33958 37212 NC_001655 3326 3327 7703 12079 16455 20831 25207 29583 33959 37213 39918 NC_001655 3327 3328 7704 12080 16456 20832 25208 29584 33960 37214 NC_001655 3328 3329 7705 12081 16457 20833 25209 29585 33961 39919 NC_001655 3329 3330 7706 12082 16458 20834 25210 29586 33962 37215 39920 NC_001655 3330 3331 7707 12083 16459 20835 25211 29587 33963 37216 NC_001655 3331 3332 7708 12084 16460 20836 25212 29588 33964 37217 NC_001655 3332 3333 7709 12085 16461 20837 25213 29589 33965 37218 NC_001655 3333 3334 7710 12086 16462 20838 25214 29590 33966 39921 NC_001655 3334 3335 7711 12087 16463 20839 25215 29591 33967 37219 NC_001655 3335 3336 7712 12088 16464 20840 25216 29592 33968 37220 NC_007368 3336 3337 7713 12089 16465 20841 25217 29593 33969 39922 NC_007368 3337 3338 7714 12090 16466 20842 25218 29594 33970 37221 39923 NC_007368 3338 3339 7715 12091 16467 20843 25219 29595 33971 37222 NC_007368 3339 3340 7716 12092 16468 20844 25220 29596 33972 37223 39924 NC_007368 3340 3341 7717 12093 16469 20845 25221 29597 33973 37224 39925 NC_027779 3341 3342 7718 12094 16470 20846 25222 29598 33974 39926 NC_027779 3342 3343 7719 12095 16471 20847 25223 29599 33975 37225 39927 NC_027779 3343 3344 7720 12096 16472 20848 25224 29600 33976 39928 NC_027779 3344 3345 7721 12097 16473 20849 25225 29601 33977 39929 NC_027779 3345 3346 7722 12098 16474 20850 25226 29602 33978 37226 NC_027779 3346 3347 7723 12099 16475 20851 25227 29603 33979 37227 NC_027779 3347 3348 7724 12100 16476 20852 25228 29604 33980 37228 NC_027779 3348 3349 7725 12101 16477 20853 25229 29605 33981 37229 NC_027779 3349 3350 7726 12102 16478 20854 25230 29606 33982 37230 NC_027779 3350 3351 7727 12103 16479 20855 25231 29607 33983 39930 NC_027779 3351 3352 7728 12104 16480 20856 25232 29608 33984 37231 NC_027779 3352 3353 7729 12105 16481 20857 25233 29609 33985 37232 NC_004908 3353 3354 7730 12106 16482 20858 25234 29610 33986 37233 NC_004908 3354 3355 7731 12107 16483 20859 25235 29611 33987 37234 NC_004908 3355 3356 7732 12108 16484 20860 25236 29612 33988 37235 NC_004908 3356 3357 7733 12109 16485 20861 25237 29613 33989 37236 NC_004908 3357 3358 7734 12110 16486 20862 25238 29614 33990 39931 NC_009826 3358 3359 7735 12111 16487 20863 25239 29615 33991 39932 NC_009826 3359 3360 7736 12112 16488 20864 25240 29616 33992 37237 39933 NC_009826 3360 3361 7737 12113 16489 20865 25241 29617 33993 39934 NC_009826 3361 3362 7738 12114 16490 20866 25242 29618 33994 39935 NC_009826 3362 3363 7739 12115 16491 20867 25243 29619 33995 39936 NC_009826 3363 3364 7740 12116 16492 20868 25244 29620 33996 37238 39937 NC_009826 3364 3365 7741 12117 16493 20869 25245 29621 33997 37239 NC_009826 3365 3366 7742 12118 16494 20870 25246 29622 33998 37240 39938 NC_009826 3366 3367 7743 12119 16495 20871 25247 29623 33999 37241 39939 NC_009826 3367 3368 7744 12120 16496 20872 25248 29624 34000 37242 NC_009826 3368 3369 7745 12121 16497 20873 25249 29625 34001 39940 NC_009826 3369 3370 7746 12122 16498 20874 25250 29626 34002 37243 39941 NC_009826 3370 3371 7747 12123 16499 20875 25251 29627 34003 37244 NC_009826 3371 3372 7748 12124 16500 20876 25252 29628 34004 39942 NC_009826 3372 3373 7749 12125 16501 20877 25253 29629 34005 37245 39943 NC_009826 3373 3374 7750 12126 16502 20878 25254 29630 34006 39944 NC_009826 3374 3375 7751 12127 16503 20879 25255 29631 34007 37246 39945 NC_009826 3375 3376 7752 12128 16504 20880 25256 29632 34008 37247 NC_009826 3376 3377 7753 12129 16505 20881 25257 29633 34009 37248 39946 NC_009826 3377 3378 7754 12130 16506 20882 25258 29634 34010 39947 NC_009826 3378 3379 7755 12131 16507 20883 25259 29635 34011 37249 NC_009826 3379 3380 7756 12132 16508 20884 25260 29636 34012 37250 NC_009826 3380 3381 7757 12133 16509 20885 25261 29637 34013 37251 NC_009826 3381 3382 7758 12134 16510 20886 25262 29638 34014 39948 NC_009826 3382 3383 7759 12135 16511 20887 25263 29639 34015 37252 39949 NC_009826 3383 3384 7760 12136 16512 20888 25264 29640 34016 37253 NC_009826 3384 3385 7761 12137 16513 20889 25265 29641 34017 37254 NC_004718 3385 3386 7762 12138 16514 20890 25266 29642 34018 39950 NC_004718 3386 3387 7763 12139 16515 20891 25267 29643 34019 37255 NC_004718 3387 3388 7764 12140 16516 20892 25268 29644 34020 37256 NC_004718 3388 3389 7765 12141 16517 20893 25269 29645 34021 37257 39951 NC_004718 3389 3390 7766 12142 16518 20894 25270 29646 34022 39952 NC_004718 3390 3391 7767 12143 16519 20895 25271 29647 34023 37258 NC_004718 3391 3392 7768 12144 16520 20896 25272 29648 34024 37259 39953 NC_004718 3392 3393 7769 12145 16521 20897 25273 29649 34025 39954 NC_004718 3393 3394 7770 12146 16522 20898 25274 29650 34026 39955 NC_004718 3394 3395 7771 12147 16523 20899 25275 29651 34027 37260 39956 NC_004718 3395 3396 7772 12148 16524 20900 25276 29652 34028 37261 39957 NC_004718 3396 3397 7773 12149 16525 20901 25277 29653 34029 39958 NC_004718 3397 3398 7774 12150 16526 20902 25278 29654 34030 37262 NC_004718 3398 3399 7775 12151 16527 20903 25279 29655 34031 39959 NC_004718 3399 3400 7776 12152 16528 20904 25280 29656 34032 39960 NC_004718 3400 3401 7777 12153 16529 20905 25281 29657 34033 37263 NC_004718 3401 3402 7778 12154 16530 20906 25282 29658 34034 37264 39961 NC_004718 3402 3403 7779 12155 16531 20907 25283 29659 34035 37265 NC_004718 3403 3404 7780 12156 16532 20908 25284 29660 34036 37266 NC_004718 3404 3405 7781 12157 16533 20909 25285 29661 34037 39962 NC_004718 3405 3406 7782 12158 16534 20910 25286 29662 34038 39963 NC_004718 3406 3407 7783 12159 16535 20911 25287 29663 34039 39964 NC_004718 3407 3408 7784 12160 16536 20912 25288 29664 34040 37267 NC_004718 3408 3409 7785 12161 16537 20913 25289 29665 34041 37268 NC_004718 3409 3410 7786 12162 16538 20914 25290 29666 34042 37269 NC_004718 3410 3411 7787 12163 16539 20915 25291 29667 34043 37270 NC_004718 3411 3412 7788 12164 16540 20916 25292 29668 34044 37271 NC_004718 3412 3413 7789 12165 16541 20917 25293 29669 34045 37272 NC_004718 3413 3414 7790 12166 16542 20918 25294 29670 34046 39965 NC_004718 3414 3415 7791 12167 16543 20919 25295 29671 34047 39966 NC_004718 3415 3416 7792 12168 16544 20920 25296 29672 34048 37273 39967 NC_004718 3416 3417 7793 12169 16545 20921 25297 29673 34049 39968 NC_004718 3417 3418 7794 12170 16546 20922 25298 29674 34050 37274 NC_004718 3418 3419 7795 12171 16547 20923 25299 29675 34051 37275 NC_004718 3419 3420 7796 12172 16548 20924 25300 29676 34052 39969 NC_004718 3420 3421 7797 12173 16549 20925 25301 29677 34053 37276 NC_004718 3421 3422 7798 12174 16550 20926 25302 29678 34054 37277 NC_004718 3422 3423 7799 12175 16551 20927 25303 29679 34055 37278 NC_004718 3423 3424 7800 12176 16552 20928 25304 29680 34056 39970 NC_004718 3424 3425 7801 12177 16553 20929 25305 29681 34057 37279 NC_004718 3425 3426 7802 12178 16554 20930 25306 29682 34058 39971 NC_004718 3426 3427 7803 12179 16555 20931 25307 29683 34059 37280 NC_004718 3427 3428 7804 12180 16556 20932 25308 29684 34060 37281 NC_004718 3428 3429 7805 12181 16557 20933 25309 29685 34061 37282 NC_004718 3429 3430 7806 12182 16558 20934 25310 29686 34062 39972 NC_004718 3430 3431 7807 12183 16559 20935 25311 29687 34063 37283 NC_004718 3431 3432 7808 12184 16560 20936 25312 29688 34064 37284 NC_004718 3432 3433 7809 12185 16561 20937 25313 29689 34065 37285 NC_004718 3433 3434 7810 12186 16562 20938 25314 29690 34066 37286 NC_004718 3434 3435 7811 12187 16563 20939 25315 29691 34067 39973 NC_004718 3435 3436 7812 12188 16564 20940 25316 29692 34068 37287 39974 NC_004718 3436 3437 7813 12189 16565 20941 25317 29693 34069 37288 39975 NC_004718 3437 3438 7814 12190 16566 20942 25318 29694 34070 39976 NC_004718 3438 3439 7815 12191 16567 20943 25319 29695 34071 37289 39977 NC_004718 3439 3440 7816 12192 16568 20944 25320 29696 34072 37290 39978 NC_004718 3440 3441 7817 12193 16569 20945 25321 29697 34073 39979 NC_004718 3441 3442 7818 12194 16570 20946 25322 29698 34074 39980 NC_004718 3442 3443 7819 12195 16571 20947 25323 29699 34075 39981 NC_004718 3443 3444 7820 12196 16572 20948 25324 29700 34076 37291 NC_004718 3444 3445 7821 12197 16573 20949 25325 29701 34077 37292 NC_004718 3445 3446 7822 12198 16574 20950 25326 29702 34078 37293 39982 NC_004718 3446 3447 7823 12199 16575 20951 25327 29703 34079 37294 NC_004718 3447 3448 7824 12200 16576 20952 25328 29704 34080 37295 NC_004718 3448 3449 7825 12201 16577 20953 25329 29705 34081 39983 NC_004718 3449 3450 7826 12202 16578 20954 25330 29706 34082 37296 NC_004718 3450 3451 7827 12203 16579 20955 25331 29707 34083 39984 NC_004718 3451 3452 7828 12204 16580 20956 25332 29708 34084 37297 39985 NC_004718 3452 3453 7829 12205 16581 20957 25333 29709 34085 37298 39986 NC_004718 3453 3454 7830 12206 16582 20958 25334 29710 34086 37299 NC_004718 3454 3455 7831 12207 16583 20959 25335 29711 34087 37300 39987 NC_004718 3455 3456 7832 12208 16584 20960 25336 29712 34088 37301 NC_004718 3456 3457 7833 12209 16585 20961 25337 29713 34089 39988 NC_004718 3457 3458 7834 12210 16586 20962 25338 29714 34090 37302 NC_004718 3458 3459 7835 12211 16587 20963 25339 29715 34091 37303 NC_004718 3459 3460 7836 12212 16588 20964 25340 29716 34092 37304 39989 NC_004718 3460 3461 7837 12213 16589 20965 25341 29717 34093 37305 NC_004718 3461 3462 7838 12214 16590 20966 25342 29718 34094 39990 NC_004718 3462 3463 7839 12215 16591 20967 25343 29719 34095 37306 39991 NC_004718 3463 3464 7840 12216 16592 20968 25344 29720 34096 37307 39992 NC_004718 3464 3465 7841 12217 16593 20969 25345 29721 34097 39993 NC_004718 3465 3466 7842 12218 16594 20970 25346 29722 34098 39994 NC_004718 3466 3467 7843 12219 16595 20971 25347 29723 34099 39995 NC_004718 3467 3468 7844 12220 16596 20972 25348 29724 34100 37308 NC_004718 3468 3469 7845 12221 16597 20973 25349 29725 34101 39996 NC_004718 3469 3470 7846 12222 16598 20974 25350 29726 34102 39997 NC_004718 3470 3471 7847 12223 16599 20975 25351 29727 34103 39998 NC_001617 3471 3472 7848 12224 16600 20976 25352 29728 34104 39999 NC_001617 3472 3473 7849 12225 16601 20977 25353 29729 34105 37309 40000 NC_001617 3473 3474 7850 12226 16602 20978 25354 29730 34106 40001 NC_001617 3474 3475 7851 12227 16603 20979 25355 29731 34107 40002 NC_001617 3475 3476 7852 12228 16604 20980 25356 29732 34108 37310 NC_001617 3476 3477 7853 12229 16605 20981 25357 29733 34109 37311 NC_001617 3477 3478 7854 12230 16606 20982 25358 29734 34110 40003 NC_001617 3478 3479 7855 12231 16607 20983 25359 29735 34111 40004 NC_001617 3479 3480 7856 12232 16608 20984 25360 29736 34112 37312 NC_001617 3480 3481 7857 12233 16609 20985 25361 29737 34113 40005 NC_001617 3481 3482 7858 12234 16610 20986 25362 29738 34114 40006 NC_001617 3482 3483 7859 12235 16611 20987 25363 29739 34115 37313 NC_001617 3483 3484 7860 12236 16612 20988 25364 29740 34116 40007 NC_001617 3484 3485 7861 12237 16613 20989 25365 29741 34117 37314 NC_001617 3485 3486 7862 12238 16614 20990 25366 29742 34118 37315 NC_001617 3486 3487 7863 12239 16615 20991 25367 29743 34119 37316 NC_001617 3487 3488 7864 12240 16616 20992 25368 29744 34120 37317 NC_001617 3488 3489 7865 12241 16617 20993 25369 29745 34121 40008 NC_001617 3489 3490 7866 12242 16618 20994 25370 29746 34122 37318 NC_001617 3490 3491 7867 12243 16619 20995 25371 29747 34123 37319 NC_001617 3491 3492 7868 12244 16620 20996 25372 29748 34124 40009 NC_001617 3492 3493 7869 12245 16621 20997 25373 29749 34125 40010 NC_014954 3493 3494 7870 12246 16622 20998 25374 29750 34126 40011 NC_014954 3494 3495 7871 12247 16623 20999 25375 29751 34127 37320 NC_014954 3495 3496 7872 12248 16624 21000 25376 29752 34128 37321 NC_014954 3496 3497 7873 12249 16625 21001 25377 29753 34129 37322 NC_014954 3497 3498 7874 12250 16626 21002 25378 29754 34130 37323 40012 NC_014954 3498 3499 7875 12251 16627 21003 25379 29755 34131 37324 NC_014954 3499 3500 7876 12252 16628 21004 25380 29756 34132 37325 NC_014954 3500 3501 7877 12253 16629 21005 25381 29757 34133 37326 40013 NC_014954 3501 3502 7878 12254 16630 21006 25382 29758 34134 40014 NC_014954 3502 3503 7879 12255 16631 21007 25383 29759 34135 40015 NC_014954 3503 3504 7880 12256 16632 21008 25384 29760 34136 40016 NC_014954 3504 3505 7881 12257 16633 21009 25385 29761 34137 40017 NC_014954 3505 3506 7882 12258 16634 21010 25386 29762 34138 40018 NC_017993 3506 3507 7883 12259 16635 21011 25387 29763 34139 40019 NC_017993 3507 3508 7884 12260 16636 21012 25388 29764 34140 37327 NC_017993 3508 3509 7885 12261 16637 21013 25389 29765 34141 37328 NC_017993 3509 3510 7886 12262 16638 21014 25390 29766 34142 37329 NC_017993 3510 3511 7887 12263 16639 21015 25391 29767 34143 40020 NC_017993 3511 3512 7888 12264 16640 21016 25392 29768 34144 37330 NC_017993 3512 3513 7889 12265 16641 21017 25393 29769 34145 37331 NC_017993 3513 3514 7890 12266 16642 21018 25394 29770 34146 40021 NC_017993 3514 3515 7891 12267 16643 21019 25395 29771 34147 37332 NC_002210 3515 3516 7892 12268 16644 21020 25396 29772 34148 37333 NC_002210 3516 3517 7893 12269 16645 21021 25397 29773 34149 37334 NC_002210 3517 3518 7894 12270 16646 21022 25398 29774 34150 37335 NC_007360 3518 3519 7895 12271 16647 21023 25399 29775 34151 40022 NC_007360 3519 3520 7896 12272 16648 21024 25400 29776 34152 37336 40023 NC_007360 3520 3521 7897 12273 16649 21025 25401 29777 34153 40024 NC_007360 3521 3522 7898 12274 16650 21026 25402 29778 34154 37337 NZ_LN831034 3522 3523 7899 12275 16651 21027 25403 29779 34155 37338 NZ_LN831034 3523 3524 7900 12276 16652 21028 25404 29780 34156 37339 NZ_LN831034 3524 3525 7901 12277 16653 21029 25405 29781 34157 40025 NZ_LN831034 3525 3526 7902 12278 16654 21030 25406 29782 34158 37340 NZ_LN831034 3526 3527 7903 12279 16655 21031 25407 29783 34159 40026 NZ_LN831034 3527 3528 7904 12280 16656 21032 25408 29784 34160 40027 NZ_LN831034 3528 3529 7905 12281 16657 21033 25409 29785 34161 37341 NZ_LN831034 3529 3530 7906 12282 16658 21034 25410 29786 34162 37342 NZ_LN831034 3530 3531 7907 12283 16659 21035 25411 29787 34163 37343 NZ_LN831034 3531 3532 7908 12284 16660 21036 25412 29788 34164 37344 NZ_LN831034 3532 3533 7909 12285 16661 21037 25413 29789 34165 40028 NZ_LN831034 3533 3534 7910 12286 16662 21038 25414 29790 34166 37345 NZ_LN831034 3534 3535 7911 12287 16663 21039 25415 29791 34167 40029 NZ_LN831034 3535 3536 7912 12288 16664 21040 25416 29792 34168 40030 NZ_LN831034 3536 3537 7913 12289 16665 21041 25417 29793 34169 40031 NZ_LN831034 3537 3538 7914 12290 16666 21042 25418 29794 34170 37346 NZ_LN831034 3538 3539 7915 12291 16667 21043 25419 29795 34171 37347 NZ_LN831034 3539 3540 7916 12292 16668 21044 25420 29796 34172 40032 NZ_LN831034 3540 3541 7917 12293 16669 21045 25421 29797 34173 37348 NZ_LN831034 3541 3542 7918 12294 16670 21046 25422 29798 34174 40033 NZ_LN831034 3542 3543 7919 12295 16671 21047 25423 29799 34175 40034 NZ_LN831034 3543 3544 7920 12296 16672 21048 25424 29800 34176 37349 NZ_LN831034 3544 3545 7921 12297 16673 21049 25425 29801 34177 40035 NZ_LN831034 3545 3546 7922 12298 16674 21050 25426 29802 34178 40036 NZ_LN831034 3546 3547 7923 12299 16675 21051 25427 29803 34179 37350 40037 NZ_LN831034 3547 3548 7924 12300 16676 21052 25428 29804 34180 37351 NZ_LN831034 3548 3549 7925 12301 16677 21053 25429 29805 34181 37352 NZ_LN831034 3549 3550 7926 12302 16678 21054 25430 29806 34182 37353 NZ_LN831034 3550 3551 7927 12303 16679 21055 25431 29807 34183 37354 40038 NZ_LN831034 3551 3552 7928 12304 16680 21056 25432 29808 34184 40039 NZ_LN831034 3552 3553 7929 12305 16681 21057 25433 29809 34185 40040 NZ_LN831034 3553 3554 7930 12306 16682 21058 25434 29810 34186 37355 NZ_LN831034 3554 3555 7931 12307 16683 21059 25435 29811 34187 40041 NZ_LN831034 3555 3556 7932 12308 16684 21060 25436 29812 34188 37356 40042 NZ_LN831034 3556 3557 7933 12309 16685 21061 25437 29813 34189 37357 NZ_LN831034 3557 3558 7934 12310 16686 21062 25438 29814 34190 40043 NZ_LN831034 3558 3559 7935 12311 16687 21063 25439 29815 34191 40044 NZ_LN831034 3559 3560 7936 12312 16688 21064 25440 29816 34192 37358 NZ_LN831034 3560 3561 7937 12313 16689 21065 25441 29817 34193 37359 40045 NZ_LN831034 3561 3562 7938 12314 16690 21066 25442 29818 34194 40046 NZ_LN831034 3562 3563 7939 12315 16691 21067 25443 29819 34195 37360 40047 NZ_LN831034 3563 3564 7940 12316 16692 21068 25444 29820 34196 37361 NZ_LN831034 3564 3565 7941 12317 16693 21069 25445 29821 34197 37362 NZ_LN831034 3565 3566 7942 12318 16694 21070 25446 29822 34198 40048 NZ_LN831034 3566 3567 7943 12319 16695 21071 25447 29823 34199 40049 NZ_LN831034 3567 3568 7944 12320 16696 21072 25448 29824 34200 37363 NZ_LN831034 3568 3569 7945 12321 16697 21073 25449 29825 34201 37364 NZ_LN831034 3569 3570 7946 12322 16698 21074 25450 29826 34202 37365 NZ_LN831034 3570 3571 7947 12323 16699 21075 25451 29827 34203 37366 NZ_LN831034 3571 3572 7948 12324 16700 21076 25452 29828 34204 37367 NZ_LN831034 3572 3573 7949 12325 16701 21077 25453 29829 34205 40050 NZ_LN831034 3573 3574 7950 12326 16702 21078 25454 29830 34206 37368 40051 NZ_LN831034 3574 3575 7951 12327 16703 21079 25455 29831 34207 37369 NZ_LN831034 3575 3576 7952 12328 16704 21080 25456 29832 34208 37370 NZ_LN831034 3576 3577 7953 12329 16705 21081 25457 29833 34209 40052 NZ_LN831034 3577 3578 7954 12330 16706 21082 25458 29834 34210 40053 NZ_LN831034 3578 3579 7955 12331 16707 21083 25459 29835 34211 37371 40054 NZ_LN831034 3579 3580 7956 12332 16708 21084 25460 29836 34212 37372 NZ_LN831034 3580 3581 7957 12333 16709 21085 25461 29837 34213 37373 NZ_LN831034 3581 3582 7958 12334 16710 21086 25462 29838 34214 37374 NZ_LN831034 3582 3583 7959 12335 16711 21087 25463 29839 34215 37375 NZ_LN831034 3583 3584 7960 12336 16712 21088 25464 29840 34216 37376 40055 NZ_LN831034 3584 3585 7961 12337 16713 21089 25465 29841 34217 37377 40056 NZ_LN831034 3585 3586 7962 12338 16714 21090 25466 29842 34218 37378 NZ_LN831034 3586 3587 7963 12339 16715 21091 25467 29843 34219 37379 NZ_LN831034 3587 3588 7964 12340 16716 21092 25468 29844 34220 37380 NZ_LN831034 3588 3589 7965 12341 16717 21093 25469 29845 34221 37381 40057 NZ_LN831034 3589 3590 7966 12342 16718 21094 25470 29846 34222 40058 NZ_LN831034 3590 3591 7967 12343 16719 21095 25471 29847 34223 37382 40059 NZ_LN831034 3591 3592 7968 12344 16720 21096 25472 29848 34224 40060 NZ_LN831034 3592 3593 7969 12345 16721 21097 25473 29849 34225 40061 NZ_LN831034 3593 3594 7970 12346 16722 21098 25474 29850 34226 40062 NZ_LN831034 3594 3595 7971 12347 16723 21099 25475 29851 34227 37383 40063 NZ_LN831034 3595 3596 7972 12348 16724 21100 25476 29852 34228 37384 NZ_LN831034 3596 3597 7973 12349 16725 21101 25477 29853 34229 37385 40064 NZ_LN831034 3597 3598 7974 12350 16726 21102 25478 29854 34230 40065 NZ_LN831034 3598 3599 7975 12351 16727 21103 25479 29855 34231 37386 NZ_LN831034 3599 3600 7976 12352 16728 21104 25480 29856 34232 40066 NZ_LN831034 3600 3601 7977 12353 16729 21105 25481 29857 34233 37387 NZ_LN831034 3601 3602 7978 12354 16730 21106 25482 29858 34234 37388 NZ_LN831034 3602 3603 7979 12355 16731 21107 25483 29859 34235 40067 NZ_LN831034 3603 3604 7980 12356 16732 21108 25484 29860 34236 40068 NZ_LN831034 3604 3605 7981 12357 16733 21109 25485 29861 34237 37389 NZ_LN831034 3605 3606 7982 12358 16734 21110 25486 29862 34238 37390 40069 NZ_LN831034 3606 3607 7983 12359 16735 21111 25487 29863 34239 37391 NZ_LN831034 3607 3608 7984 12360 16736 21112 25488 29864 34240 40070 NZ_LN831034 3608 3609 7985 12361 16737 21113 25489 29865 34241 40071 NZ_LN831034 3609 3610 7986 12362 16738 21114 25490 29866 34242 37392 NZ_LN831034 3610 3611 7987 12363 16739 21115 25491 29867 34243 37393 NZ_LN831034 3611 3612 7988 12364 16740 21116 25492 29868 34244 37394 40072 NZ_LN831034 3612 3613 7989 12365 16741 21117 25493 29869 34245 40073 NZ_LN831034 3613 3614 7990 12366 16742 21118 25494 29870 34246 37395 NZ_LN831034 3614 3615 7991 12367 16743 21119 25495 29871 34247 40074 NZ_LN831034 3615 3616 7992 12368 16744 21120 25496 29872 34248 37396 40075 NZ_LN831034 3616 3617 7993 12369 16745 21121 25497 29873 34249 37397 NZ_LN831034 3617 3618 7994 12370 16746 21122 25498 29874 34250 40076 NZ_LN831034 3618 3619 7995 12371 16747 21123 25499 29875 34251 40077 NZ_LN831034 3619 3620 7996 12372 16748 21124 25500 29876 34252 37398 NZ_LN831034 3620 3621 7997 12373 16749 21125 25501 29877 34253 37399 NZ_LN831034 3621 3622 7998 12374 16750 21126 25502 29878 34254 37400 NZ_LN831034 3622 3623 7999 12375 16751 21127 25503 29879 34255 37401 NZ_LN831034 3623 3624 8000 12376 16752 21128 25504 29880 34256 37402 40078 NZ_LN831034 3624 3625 8001 12377 16753 21129 25505 29881 34257 40079 NZ_LN831034 3625 3626 8002 12378 16754 21130 25506 29882 34258 40080 NZ_LN831034 3626 3627 8003 12379 16755 21131 25507 29883 34259 40081 NZ_LN831034 3627 3628 8004 12380 16756 21132 25508 29884 34260 37403 NZ_LN831034 3628 3629 8005 12381 16757 21133 25509 29885 34261 40082 NZ_LN831034 3629 3630 8006 12382 16758 21134 25510 29886 34262 40083 NZ_LN831034 3630 3631 8007 12383 16759 21135 25511 29887 34263 37404 40084 NZ_LN831034 3631 3632 8008 12384 16760 21136 25512 29888 34264 40085 NZ_LN831034 3632 3633 8009 12385 16761 21137 25513 29889 34265 37405 NZ_LN831034 3633 3634 8010 12386 16762 21138 25514 29890 34266 40086 NZ_LN831034 3634 3635 8011 12387 16763 21139 25515 29891 34267 37406 40087 NZ_LN831034 3635 3636 8012 12388 16764 21140 25516 29892 34268 37407 40088 NZ_LN831034 3636 3637 8013 12389 16765 21141 25517 29893 34269 37408 NZ_LN831034 3637 3638 8014 12390 16766 21142 25518 29894 34270 40089 NZ_LN831034 3638 3639 8015 12391 16767 21143 25519 29895 34271 40090 NZ_LN831034 3639 3640 8016 12392 16768 21144 25520 29896 34272 37409 NZ_LN831034 3640 3641 8017 12393 16769 21145 25521 29897 34273 37410 NZ_LN831034 3641 3642 8018 12394 16770 21146 25522 29898 34274 37411 NZ_LN831034 3642 3643 8019 12395 16771 21147 25523 29899 34275 40091 NZ_LN831034 3643 3644 8020 12396 16772 21148 25524 29900 34276 37412 NZ_LN831034 3644 3645 8021 12397 16773 21149 25525 29901 34277 40092 NZ_LN831034 3645 3646 8022 12398 16774 21150 25526 29902 34278 37413 NZ_LN831034 3646 3647 8023 12399 16775 21151 25527 29903 34279 37414 NZ_LN831034 3647 3648 8024 12400 16776 21152 25528 29904 34280 37415 40093 NZ_LN831034 3648 3649 8025 12401 16777 21153 25529 29905 34281 37416 40094 NZ_LN831034 3649 3650 8026 12402 16778 21154 25530 29906 34282 40095 NZ_LN831034 3650 3651 8027 12403 16779 21155 25531 29907 34283 37417 NZ_LN831034 3651 3652 8028 12404 16780 21156 25532 29908 34284 37418 NZ_LN831034 3652 3653 8029 12405 16781 21157 25533 29909 34285 37419 NZ_LN831034 3653 3654 8030 12406 16782 21158 25534 29910 34286 40096 NZ_LN831034 3654 3655 8031 12407 16783 21159 25535 29911 34287 37420 NZ_LN831034 3655 3656 8032 12408 16784 21160 25536 29912 34288 40097 NZ_LN831034 3656 3657 8033 12409 16785 21161 25537 29913 34289 37421 NZ_LN831034 3657 3658 8034 12410 16786 21162 25538 29914 34290 37422 NZ_LN831034 3658 3659 8035 12411 16787 21163 25539 29915 34291 37423 NZ_LN831034 3659 3660 8036 12412 16788 21164 25540 29916 34292 37424 NZ_LN831034 3660 3661 8037 12413 16789 21165 25541 29917 34293 40098 NZ_LN831034 3661 3662 8038 12414 16790 21166 25542 29918 34294 40099 NZ_LN831034 3662 3663 8039 12415 16791 21167 25543 29919 34295 37425 NZ_LN831034 3663 3664 8040 12416 16792 21168 25544 29920 34296 40100 NZ_LN831034 3664 3665 8041 12417 16793 21169 25545 29921 34297 37426 40101 NZ_LN831034 3665 3666 8042 12418 16794 21170 25546 29922 34298 37427 NZ_LN831034 3666 3667 8043 12419 16795 21171 25547 29923 34299 37428 NZ_LN831034 3667 3668 8044 12420 16796 21172 25548 29924 34300 37429 40102 NZ_LN831034 3668 3669 8045 12421 16797 21173 25549 29925 34301 37430 NZ_LN831034 3669 3670 8046 12422 16798 21174 25550 29926 34302 40103 NZ_LN831034 3670 3671 8047 12423 16799 21175 25551 29927 34303 37431 NZ_LN831034 3671 3672 8048 12424 16800 21176 25552 29928 34304 37432 40104 NC_038504 3672 3673 8049 12425 16801 21177 25553 29929 34305 37433 NC_038504 3673 3674 8050 12426 16802 21178 25554 29930 34306 40105 NC_038504 3674 3675 8051 12427 16803 21179 25555 29931 34307 37434 NC_038504 3675 3676 8052 12428 16804 21180 25556 29932 34308 37435 NC_038504 3676 3677 8053 12429 16805 21181 25557 29933 34309 37436 NC_038504 3677 3678 8054 12430 16806 21182 25558 29934 34310 40106 NC_038504 3678 3679 8055 12431 16807 21183 25559 29935 34311 37437 NC_038504 3679 3680 8056 12432 16808 21184 25560 29936 34312 37438 40107 NC_038504 3680 3681 8057 12433 16809 21185 25561 29937 34313 40108 NC_038504 3681 3682 8058 12434 16810 21186 25562 29938 34314 37439 NC_038504 3682 3683 8059 12435 16811 21187 25563 29939 34315 37440 40109 NC_038504 3683 3684 8060 12436 16812 21188 25564 29940 34316 40110 NC_038504 3684 3685 8061 12437 16813 21189 25565 29941 34317 40111 NC_038504 3685 3686 8062 12438 16814 21190 25566 29942 34318 37441 NC_038504 3686 3687 8063 12439 16815 21191 25567 29943 34319 37442 40112 NC_038504 3687 3688 8064 12440 16816 21192 25568 29944 34320 40113 NC_038504 3688 3689 8065 12441 16817 21193 25569 29945 34321 37443 40114 NC_038504 3689 3690 8066 12442 16818 21194 25570 29946 34322 37444 NC_038504 3690 3691 8067 12443 16819 21195 25571 29947 34323 37445 NC_038504 3691 3692 8068 12444 16820 21196 25572 29948 34324 40115 NC_038504 3692 3693 8069 12445 16821 21197 25573 29949 34325 37446 40116 NC_038504 3693 3694 8070 12446 16822 21198 25574 29950 34326 37447 NC_005831 3694 3695 8071 12447 16823 21199 25575 29951 34327 37448 NC_005831 3695 3696 8072 12448 16824 21200 25576 29952 34328 37449 NC_005831 3696 3697 8073 12449 16825 21201 25577 29953 34329 40117 NC_005831 3697 3698 8074 12450 16826 21202 25578 29954 34330 40118 NC_005831 3698 3699 8075 12451 16827 21203 25579 29955 34331 37450 40119 NC_005831 3699 3700 8076 12452 16828 21204 25580 29956 34332 37451 NC_005831 3700 3701 8077 12453 16829 21205 25581 29957 34333 40120 NC_005831 3701 3702 8078 12454 16830 21206 25582 29958 34334 37452 NC_005831 3702 3703 8079 12455 16831 21207 25583 29959 34335 37453 NC_005831 3703 3704 8080 12456 16832 21208 25584 29960 34336 40121 NC_005831 3704 3705 8081 12457 16833 21209 25585 29961 34337 37454 NC_005831 3705 3706 8082 12458 16834 21210 25586 29962 34338 37455 40122 NC_005831 3706 3707 8083 12459 16835 21211 25587 29963 34339 40123 NC_005831 3707 3708 8084 12460 16836 21212 25588 29964 34340 40124 NC_005831 3708 3709 8085 12461 16837 21213 25589 29965 34341 37456 NC_005831 3709 3710 8086 12462 16838 21214 25590 29966 34342 37457 NC_005831 3710 3711 8087 12463 16839 21215 25591 29967 34343 40125 NC_005831 3711 3712 8088 12464 16840 21216 25592 29968 34344 37458 NC_005831 3712 3713 8089 12465 16841 21217 25593 29969 34345 37459 NC_005831 3713 3714 8090 12466 16842 21218 25594 29970 34346 37460 NC_005831 3714 3715 8091 12467 16843 21219 25595 29971 34347 40126 NC_005831 3715 3716 8092 12468 16844 21220 25596 29972 34348 37461 NC_005831 3716 3717 8093 12469 16845 21221 25597 29973 34349 37462 NC_005831 3717 3718 8094 12470 16846 21222 25598 29974 34350 37463 NC_005831 3718 3719 8095 12471 16847 21223 25599 29975 34351 37464 NC_005831 3719 3720 8096 12472 16848 21224 25600 29976 34352 40127 NC_005831 3720 3721 8097 12473 16849 21225 25601 29977 34353 37465 NC_005831 3721 3722 8098 12474 16850 21226 25602 29978 34354 37466 NC_005831 3722 3723 8099 12475 16851 21227 25603 29979 34355 37467 40128 NC_005831 3723 3724 8100 12476 16852 21228 25604 29980 34356 40129 NC_005831 3724 3725 8101 12477 16853 21229 25605 29981 34357 37468 NC_005831 3725 3726 8102 12478 16854 21230 25606 29982 34358 37469 NC_005831 3726 3727 8103 12479 16855 21231 25607 29983 34359 40130 NC_005831 3727 3728 8104 12480 16856 21232 25608 29984 34360 37470 NC_005831 3728 3729 8105 12481 16857 21233 25609 29985 34361 37471 NC_005831 3729 3730 8106 12482 16858 21234 25610 29986 34362 40131 NC_005831 3730 3731 8107 12483 16859 21235 25611 29987 34363 40132 NC_005831 3731 3732 8108 12484 16860 21236 25612 29988 34364 40133 NC_005831 3732 3733 8109 12485 16861 21237 25613 29989 34365 40134 NC_005831 3733 3734 8110 12486 16862 21238 25614 29990 34366 40135 NC_005831 3734 3735 8111 12487 16863 21239 25615 29991 34367 37472 40136 NC_005831 3735 3736 8112 12488 16864 21240 25616 29992 34368 37473 NC_005831 3736 3737 8113 12489 16865 21241 25617 29993 34369 40137 NC_005831 3737 3738 8114 12490 16866 21242 25618 29994 34370 37474 NC_005831 3738 3739 8115 12491 16867 21243 25619 29995 34371 40138 NC_005831 3739 3740 8116 12492 16868 21244 25620 29996 34372 40139 NC_005831 3740 3741 8117 12493 16869 21245 25621 29997 34373 37475 NC_005831 3741 3742 8118 12494 16870 21246 25622 29998 34374 37476 NC_005831 3742 3743 8119 12495 16871 21247 25623 29999 34375 37477 NC_005831 3743 3744 8120 12496 16872 21248 25624 30000 34376 40140 NC_005831 3744 3745 8121 12497 16873 21249 25625 30001 34377 37478 NC_005831 3745 3746 8122 12498 16874 21250 25626 30002 34378 37479 NC_005831 3746 3747 8123 12499 16875 21251 25627 30003 34379 37480 NC_001356 3747 3748 8124 12500 16876 21252 25628 30004 34380 40141 NC_001356 3748 3749 8125 12501 16877 21253 25629 30005 34381 37481 NC_001356 3749 3750 8126 12502 16878 21254 25630 30006 34382 37482 40142 NC_001356 3750 3751 8127 12503 16879 21255 25631 30007 34383 37483 NC_001356 3751 3752 8128 12504 16880 21256 25632 30008 34384 40143 NC_001356 3752 3753 8129 12505 16881 21257 25633 30009 34385 37484 NC_001356 3753 3754 8130 12506 16882 21258 25634 30010 34386 37485 NC_001356 3754 3755 8131 12507 16883 21259 25635 30011 34387 40144 NC_001356 3755 3756 8132 12508 16884 21260 25636 30012 34388 37486 40145 NC_001356 3756 3757 8133 12509 16885 21261 25637 30013 34389 37487 40146 NC_001356 3757 3758 8134 12510 16886 21262 25638 30014 34390 37488 40147 NC_001356 3758 3759 8135 12511 16887 21263 25639 30015 34391 40148 NC_001356 3759 3760 8136 12512 16888 21264 25640 30016 34392 40149 NC_001356 3760 3761 8137 12513 16889 21265 25641 30017 34393 40150 NC_001356 3761 3762 8138 12514 16890 21266 25642 30018 34394 40151 NC_001356 3762 3763 8139 12515 16891 21267 25643 30019 34395 37489 NC_001356 3763 3764 8140 12516 16892 21268 25644 30020 34396 37490 NC_001356 3764 3765 8141 12517 16893 21269 25645 30021 34397 40152 NC_001356 3765 3766 8142 12518 16894 21270 25646 30022 34398 40153 NC_038525 3766 3767 8143 12519 16895 21271 25647 30023 34399 37491 NC_038525 3767 3768 8144 12520 16896 21272 25648 30024 34400 40154 NC_038525 3768 3769 8145 12521 16897 21273 25649 30025 34401 40155 NC_038525 3769 3770 8146 12522 16898 21274 25650 30026 34402 40156 NC_038525 3770 3771 8147 12523 16899 21275 25651 30027 34403 37492 NC_038525 3771 3772 8148 12524 16900 21276 25652 30028 34404 40157 NC_038525 3772 3773 8149 12525 16901 21277 25653 30029 34405 40158 NC_038525 3773 3774 8150 12526 16902 21278 25654 30030 34406 40159 NC_038525 3774 3775 8151 12527 16903 21279 25655 30031 34407 37493 40160 NC_038525 3775 3776 8152 12528 16904 21280 25656 30032 34408 37494 NC_038525 3776 3777 8153 12529 16905 21281 25657 30033 34409 37495 NC_038525 3777 3778 8154 12530 16906 21282 25658 30034 34410 40161 NC_038525 3778 3779 8155 12531 16907 21283 25659 30035 34411 40162 NC_002211 3779 3780 8156 12532 16908 21284 25660 30036 34412 40163 NC_002211 3780 3781 8157 12533 16909 21285 25661 30037 34413 40164 NC_002211 3781 3782 8158 12534 16910 21286 25662 30038 34414 37496 NC_002211 3782 3783 8159 12535 16911 21287 25663 30039 34415 37497 40165 NC_001489 3783 3784 8160 12536 16912 21288 25664 30040 34416 37498 NC_001489 3784 3785 8161 12537 16913 21289 25665 30041 34417 40166 NC_001489 3785 3786 8162 12538 16914 21290 25666 30042 34418 37499 NC_001489 3786 3787 8163 12539 16915 21291 25667 30043 34419 37500 40167 NC_001489 3787 3788 8164 12540 16916 21292 25668 30044 34420 37501 NC_001489 3788 3789 8165 12541 16917 21293 25669 30045 34421 37502 NC_001489 3789 3790 8166 12542 16918 21294 25670 30046 34422 37503 NC_001489 3790 3791 8167 12543 16919 21295 25671 30047 34423 37504 NC_001489 3791 3792 8168 12544 16920 21296 25672 30048 34424 40168 NC_001489 3792 3793 8169 12545 16921 21297 25673 30049 34425 40169 NC_001489 3793 3794 8170 12546 16922 21298 25674 30050 34426 37505 NC_001489 3794 3795 8171 12547 16923 21299 25675 30051 34427 40170 NC_001489 3795 3796 8172 12548 16924 21300 25676 30052 34428 40171 NC_001489 3796 3797 8173 12549 16925 21301 25677 30053 34429 37506 40172 NC_001489 3797 3798 8174 12550 16926 21302 25678 30054 34430 40173 NC_001489 3798 3799 8175 12551 16927 21303 25679 30055 34431 37507 NC_001489 3799 3800 8176 12552 16928 21304 25680 30056 34432 37508 NC_001489 3800 3801 8177 12553 16929 21305 25681 30057 34433 37509 NC_001489 3801 3802 8178 12554 16930 21306 25682 30058 34434 37510 NC_007366 3802 3803 8179 12555 16931 21307 25683 30059 34435 37511 NC_007366 3803 3804 8180 12556 16932 21308 25684 30060 34436 40174 NC_007366 3804 3805 8181 12557 16933 21309 25685 30061 34437 37512 NC_007366 3805 3806 8182 12558 16934 21310 25686 30062 34438 40175 NC_007366 3806 3807 8183 12559 16935 21311 25687 30063 34439 37513 40176 NC_007366 3807 3808 8184 12560 16936 21312 25688 30064 34440 37514 NC_007366 3808 3809 8185 12561 16937 21313 25689 30065 34441 37515 40177 NC_005134 3809 3810 8186 12562 16938 21314 25690 30066 34442 37516 NC_005134 3810 3811 8187 12563 16939 21315 25691 30067 34443 40178 NC_005134 3811 3812 8188 12564 16940 21316 25692 30068 34444 40179 NC_005134 3812 3813 8189 12565 16941 21317 25693 30069 34445 37517 NC_005134 3813 3814 8190 12566 16942 21318 25694 30070 34446 40180 NC_005134 3814 3815 8191 12567 16943 21319 25695 30071 34447 37518 NC_005134 3815 3816 8192 12568 16944 21320 25696 30072 34448 40181 NC_005134 3816 3817 8193 12569 16945 21321 25697 30073 34449 40182 NC_005134 3817 3818 8194 12570 16946 21322 25698 30074 34450 40183 NC_005134 3818 3819 8195 12571 16947 21323 25699 30075 34451 37519 40184 NC_005134 3819 3820 8196 12572 16948 21324 25700 30076 34452 40185 NC_005134 3820 3821 8197 12573 16949 21325 25701 30077 34453 40186 NC_005134 3821 3822 8198 12574 16950 21326 25702 30078 34454 40187 NC_005134 3822 3823 8199 12575 16951 21327 25703 30079 34455 37520 NC_007382 3823 3824 8200 12576 16952 21328 25704 30080 34456 37521 NC_007382 3824 3825 8201 12577 16953 21329 25705 30081 34457 40188 NC_007382 3825 3826 8202 12578 16954 21330 25706 30082 34458 37522 NC_007382 3826 3827 8203 12579 16955 21331 25707 30083 34459 37523 NC_007382 3827 3828 8204 12580 16956 21332 25708 30084 34460 40189 NC_001664 3828 3829 8205 12581 16957 21333 25709 30085 34461 37524 40190 NC_001664 3829 3830 8206 12582 16958 21334 25710 30086 34462 37525 40191 NC_001664 3830 3831 8207 12583 16959 21335 25711 30087 34463 37526 40192 NC_001664 3831 3832 8208 12584 16960 21336 25712 30088 34464 37527 40193 NC_001664 3832 3833 8209 12585 16961 21337 25713 30089 34465 37528 40194 NC_001664 3833 3834 8210 12586 16962 21338 25714 30090 34466 37529 NC_001664 3834 3835 8211 12587 16963 21339 25715 30091 34467 37530 NC_001664 3835 3836 8212 12588 16964 21340 25716 30092 34468 37531 NC_001664 3836 3837 8213 12589 16965 21341 25717 30093 34469 37532 NC_001664 3837 3838 8214 12590 16966 21342 25718 30094 34470 37533 NC_001664 3838 3839 8215 12591 16967 21343 25719 30095 34471 40195 NC_001664 3839 3840 8216 12592 16968 21344 25720 30096 34472 40196 NC_001664 3840 3841 8217 12593 16969 21345 25721 30097 34473 37534 40197 NC_001664 3841 3842 8218 12594 16970 21346 25722 30098 34474 37535 40198 NC_001664 3842 3843 8219 12595 16971 21347 25723 30099 34475 37536 NC_001664 3843 3844 8220 12596 16972 21348 25724 30100 34476 40199 NC_001664 3844 3845 8221 12597 16973 21349 25725 30101 34477 40200 NC_001664 3845 3846 8222 12598 16974 21350 25726 30102 34478 40201 NC_001664 3846 3847 8223 12599 16975 21351 25727 30103 34479 37537 40202 NC_001664 3847 3848 8224 12600 16976 21352 25728 30104 34480 40203 NC_001664 3848 3849 8225 12601 16977 21353 25729 30105 34481 37538 40204 NC_001664 3849 3850 8226 12602 16978 21354 25730 30106 34482 37539 NC_001664 3850 3851 8227 12603 16979 21355 25731 30107 34483 40205 NC_001664 3851 3852 8228 12604 16980 21356 25732 30108 34484 40206 NC_001664 3852 3853 8229 12605 16981 21357 25733 30109 34485 40207 NC_001664 3853 3854 8230 12606 16982 21358 25734 30110 34486 37540 40208 NC_001664 3854 3855 8231 12607 16983 21359 25735 30111 34487 37541 NC_001664 3855 3856 8232 12608 16984 21360 25736 30112 34488 37542 NC_001664 3856 3857 8233 12609 16985 21361 25737 30113 34489 37543 NC_001664 3857 3858 8234 12610 16986 21362 25738 30114 34490 37544 40209 NC_001664 3858 3859 8235 12611 16987 21363 25739 30115 34491 37545 40210 NC_001664 3859 3860 8236 12612 16988 21364 25740 30116 34492 37546 NC_002206 3860 3861 8237 12613 16989 21365 25741 30117 34493 37547 NC_002206 3861 3862 8238 12614 16990 21366 25742 30118 34494 37548 NC_002206 3862 3863 8239 12615 16991 21367 25743 30119 34495 37549 NC_002206 3863 3864 8240 12616 16992 21368 25744 30120 34496 37550 NC_002206 3864 3865 8241 12617 16993 21369 25745 30121 34497 37551 NC_002206 3865 3866 8242 12618 16994 21370 25746 30122 34498 37552 NC_026433 3866 3867 8243 12619 16995 21371 25747 30123 34499 40211 NC_026433 3867 3868 8244 12620 16996 21372 25748 30124 34500 40212 NC_026433 3868 3869 8245 12621 16997 21373 25749 30125 34501 37553 40213 NC_026433 3869 3870 8246 12622 16998 21374 25750 30126 34502 37554 NC_026433 3870 3871 8247 12623 16999 21375 25751 30127 34503 37555 40214 NC_000898 3871 3872 8248 12624 17000 21376 25752 30128 34504 40215 NC_000898 3872 3873 8249 12625 17001 21377 25753 30129 34505 37556 40216 NC_000898 3873 3874 8250 12626 17002 21378 25754 30130 34506 37557 40217 NC_000898 3874 3875 8251 12627 17003 21379 25755 30131 34507 37558 40218 NC_000898 3875 3876 8252 12628 17004 21380 25756 30132 34508 40219 NC_000898 3876 3877 8253 12629 17005 21381 25757 30133 34509 37559 NC_000898 3877 3878 8254 12630 17006 21382 25758 30134 34510 37560 NC_000898 3878 3879 8255 12631 17007 21383 25759 30135 34511 40220 NC_000898 3879 3880 8256 12632 17008 21384 25760 30136 34512 40221 NC_000898 3880 3881 8257 12633 17009 21385 25761 30137 34513 37561 40222 NC_000898 3881 3882 8258 12634 17010 21386 25762 30138 34514 40223 NC_000898 3882 3883 8259 12635 17011 21387 25763 30139 34515 37562 NC_000898 3883 3884 8260 12636 17012 21388 25764 30140 34516 40224 NC_000898 3884 3885 8261 12637 17013 21389 25765 30141 34517 40225 NC_000898 3885 3886 8262 12638 17014 21390 25766 30142 34518 40226 NC_000898 3886 3887 8263 12639 17015 21391 25767 30143 34519 37563 NC_000898 3887 3888 8264 12640 17016 21392 25768 30144 34520 40227 NC_000898 3888 3889 8265 12641 17017 21393 25769 30145 34521 37564 NC_000898 3889 3890 8266 12642 17018 21394 25770 30146 34522 37565 NC_000898 3890 3891 8267 12643 17019 21395 25771 30147 34523 37566 40228 NC_000898 3891 3892 8268 12644 17020 21396 25772 30148 34524 37567 NC_000898 3892 3893 8269 12645 17021 21397 25773 30149 34525 40229 NC_000898 3893 3894 8270 12646 17022 21398 25774 30150 34526 37568 NC_000898 3894 3895 8271 12647 17023 21399 25775 30151 34527 40230 NC_000898 3895 3896 8272 12648 17024 21400 25776 30152 34528 37569 NC_000898 3896 3897 8273 12649 17025 21401 25777 30153 34529 37570 NC_000898 3897 3898 8274 12650 17026 21402 25778 30154 34530 37571 NC_000898 3898 3899 8275 12651 17027 21403 25779 30155 34531 37572 NC_000898 3899 3900 8276 12652 17028 21404 25780 30156 34532 40231 NC_000898 3900 3901 8277 12653 17029 21405 25781 30157 34533 40232 NC_000898 3901 3902 8278 12654 17030 21406 25782 30158 34534 37573 40233 NC_000898 3902 3903 8279 12655 17031 21407 25783 30159 34535 37574 NC_000898 3903 3904 8280 12656 17032 21408 25784 30160 34536 37575 40234 NC_000898 3904 3905 8281 12657 17033 21409 25785 30161 34537 40235 NC_000898 3905 3906 8282 12658 17034 21410 25786 30162 34538 37576 40236 NC_002016 3906 3907 8283 12659 17035 21411 25787 30163 34539 37577 40237 NC_002016 3907 3908 8284 12660 17036 21412 25788 30164 34540 37578 NC_026432 3908 3909 8285 12661 17037 21413 25789 30165 34541 40238 NC_026432 3909 3910 8286 12662 17038 21414 25790 30166 34542 37579 40239 NC_026432 3910 3911 8287 12663 17039 21415 25791 30167 34543 37580 NC_001595 3911 3912 8288 12664 17040 21416 25792 30168 34544 40240 NC_001595 3912 3913 8289 12665 17041 21417 25793 30169 34545 40241 NC_001595 3913 3914 8290 12666 17042 21418 25794 30170 34546 37581 NC_001595 3914 3915 8291 12667 17043 21419 25795 30171 34547 37582 40242 NC_001595 3915 3916 8292 12668 17044 21420 25796 30172 34548 37583 40243 NC_001595 3916 3917 8293 12669 17045 21421 25797 30173 34549 37584 NC_001595 3917 3918 8294 12670 17046 21422 25798 30174 34550 37585 40244 NC_001595 3918 3919 8295 12671 17047 21423 25799 30175 34551 37586 NC_001595 3919 3920 8296 12672 17048 21424 25800 30176 34552 40245 NC_001595 3920 3921 8297 12673 17049 21425 25801 30177 34553 37587 40246 NC_001595 3921 3922 8298 12674 17050 21426 25802 30178 34554 40247 NC_001595 3922 3923 8299 12675 17051 21427 25803 30179 34555 37588 NC_001595 3923 3924 8300 12676 17052 21428 25804 30180 34556 37589 NC_001595 3924 3925 8301 12677 17053 21429 25805 30181 34557 37590 NC_001595 3925 3926 8302 12678 17054 21430 25806 30182 34558 37591 NC_001595 3926 3927 8303 12679 17055 21431 25807 30183 34559 37592 NC_001593 3927 3928 8304 12680 17056 21432 25808 30184 34560 37593 40248 NC_001593 3928 3929 8305 12681 17057 21433 25809 30185 34561 40249 NC_001593 3929 3930 8306 12682 17058 21434 25810 30186 34562 37594 40250 NC_001593 3930 3931 8307 12683 17059 21435 25811 30187 34563 37595 40251 NC_001593 3931 3932 8308 12684 17060 21436 25812 30188 34564 37596 NC_001593 3932 3933 8309 12685 17061 21437 25813 30189 34565 37597 NC_001593 3933 3934 8310 12686 17062 21438 25814 30190 34566 37598 NC_001593 3934 3935 8311 12687 17063 21439 25815 30191 34567 40252 NC_001593 3935 3936 8312 12688 17064 21440 25816 30192 34568 37599 40253 NC_001593 3936 3937 8313 12689 17065 21441 25817 30193 34569 40254 NC_001593 3937 3938 8314 12690 17066 21442 25818 30194 34570 37600 NC_001593 3938 3939 8315 12691 17067 21443 25819 30195 34571 37601 40255 NC_001593 3939 3940 8316 12692 17068 21444 25820 30196 34572 40256 NC_001593 3940 3941 8317 12693 17069 21445 25821 30197 34573 37602 40257 NC_001593 3941 3942 8318 12694 17070 21446 25822 30198 34574 40258 NC_001593 3942 3943 8319 12695 17071 21447 25823 30199 34575 37603 40259 NC_001593 3943 3944 8320 12696 17072 21448 25824 30200 34576 40260 NC_038311 3944 3945 8321 12697 17073 21449 25825 30201 34577 40261 NC_038311 3945 3946 8322 12698 17074 21450 25826 30202 34578 37604 40262 NC_038311 3946 3947 8323 12699 17075 21451 25827 30203 34579 40263 NC_038311 3947 3948 8324 12700 17076 21452 25828 30204 34580 40264 NC_038311 3948 3949 8325 12701 17077 21453 25829 30205 34581 37605 NC_038311 3949 3950 8326 12702 17078 21454 25830 30206 34582 37606 NC_038311 3950 3951 8327 12703 17079 21455 25831 30207 34583 37607 NC_038311 3951 3952 8328 12704 17080 21456 25832 30208 34584 40265 NC_038311 3952 3953 8329 12705 17081 21457 25833 30209 34585 37608 40266 NC_038311 3953 3954 8330 12706 17082 21458 25834 30210 34586 37609 NC_038311 3954 3955 8331 12707 17083 21459 25835 30211 34587 40267 NC_019023 3955 3956 8332 12708 17084 21460 25836 30212 34588 40268 NC_019023 3956 3957 8333 12709 17085 21461 25837 30213 34589 37610 NC_019023 3957 3958 8334 12710 17086 21462 25838 30214 34590 37611 NC_019023 3958 3959 8335 12711 17087 21463 25839 30215 34591 37612 NC_019023 3959 3960 8336 12712 17088 21464 25840 30216 34592 37613 NC_019023 3960 3961 8337 12713 17089 21465 25841 30217 34593 37614 NC_019023 3961 3962 8338 12714 17090 21466 25842 30218 34594 37615 NC_019023 3962 3963 8339 12715 17091 21467 25843 30219 34595 37616 NC_019023 3963 3964 8340 12716 17092 21468 25844 30220 34596 40269 NC_019023 3964 3965 8341 12717 17093 21469 25845 30221 34597 37617 40270 NC_019023 3965 3966 8342 12718 17094 21470 25846 30222 34598 40271 NC_019023 3966 3967 8343 12719 17095 21471 25847 30223 34599 40272 NC_019023 3967 3968 8344 12720 17096 21472 25848 30224 34600 37618 NC_019023 3968 3969 8345 12721 17097 21473 25849 30225 34601 37619 40273 NC_019023 3969 3970 8346 12722 17098 21474 25850 30226 34602 37620 NC_009996 3970 3971 8347 12723 17099 21475 25851 30227 34603 37621 NC_009996 3971 3972 8348 12724 17100 21476 25852 30228 34604 37622 40274 NC_009996 3972 3973 8349 12725 17101 21477 25853 30229 34605 37623 NC_009996 3973 3974 8350 12726 17102 21478 25854 30230 34606 37624 NC_009996 3974 3975 8351 12727 17103 21479 25855 30231 34607 40275 NC_009996 3975 3976 8352 12728 17104 21480 25856 30232 34608 37625 NC_009996 3976 3977 8353 12729 17105 21481 25857 30233 34609 37626 NC_009996 3977 3978 8354 12730 17106 21482 25858 30234 34610 40276 NC_009996 3978 3979 8355 12731 17107 21483 25859 30235 34611 37627 40277 NC_009996 3979 3980 8356 12732 17108 21484 25860 30236 34612 37628 NC_009996 3980 3981 8357 12733 17109 21485 25861 30237 34613 37629 40278 NC_009996 3981 3982 8358 12734 17110 21486 25862 30238 34614 40279 NC_009996 3982 3983 8359 12735 17111 21487 25863 30239 34615 40280 NC_009996 3983 3984 8360 12736 17112 21488 25864 30240 34616 40281 NC_009996 3984 3985 8361 12737 17113 21489 25865 30241 34617 37630 NC_009996 3985 3986 8362 12738 17114 21490 25866 30242 34618 37631 40282 NC_009996 3986 3987 8363 12739 17115 21491 25867 30243 34619 40283 NC_009996 3987 3988 8364 12740 17116 21492 25868 30244 34620 37632 NC_009996 3988 3989 8365 12741 17117 21493 25869 30245 34621 37633 NC_009996 3989 3990 8366 12742 17118 21494 25870 30246 34622 37634 NC_009996 3990 3991 8367 12743 17119 21495 25871 30247 34623 40284 NC_009996 3991 3992 8368 12744 17120 21496 25872 30248 34624 37635 40285 NC_009996 3992 3993 8369 12745 17121 21497 25873 30249 34625 40286 NC_007357 3993 3994 8370 12746 17122 21498 25874 30250 34626 37636 NC_007357 3994 3995 8371 12747 17123 21499 25875 30251 34627 37637 NC_007357 3995 3996 8372 12748 17124 21500 25876 30252 34628 37638 NC_007357 3996 3997 8373 12749 17125 21501 25877 30253 34629 37639 NC_007357 3997 3998 8374 12750 17126 21502 25878 30254 34630 37640 40287 NC_007357 3998 3999 8375 12751 17127 21503 25879 30255 34631 37641 NC_012959 3999 4000 8376 12752 17128 21504 25880 30256 34632 40288 NC_012959 4000 4001 8377 12753 17129 21505 25881 30257 34633 37642 40289 NC_012959 4001 4002 8378 12754 17130 21506 25882 30258 34634 40290 NC_012959 4002 4003 8379 12755 17131 21507 25883 30259 34635 37643 NC_012959 4003 4004 8380 12756 17132 21508 25884 30260 34636 37644 NC_012959 4004 4005 8381 12757 17133 21509 25885 30261 34637 37645 NC_012959 4005 4006 8382 12758 17134 21510 25886 30262 34638 37646 NC_012959 4006 4007 8383 12759 17135 21511 25887 30263 34639 40291 NC_012959 4007 4008 8384 12760 17136 21512 25888 30264 34640 40292 NC_012959 4008 4009 8385 12761 17137 21513 25889 30265 34641 37647 NC_012959 4009 4010 8386 12762 17138 21514 25890 30266 34642 37648 40293 NC_012959 4010 4011 8387 12763 17139 21515 25891 30267 34643 40294 NC_012959 4011 4012 8388 12764 17140 21516 25892 30268 34644 37649 40295 NC_012959 4012 4013 8389 12765 17141 21517 25893 30269 34645 40296 NC_012959 4013 4014 8390 12766 17142 21518 25894 30270 34646 37650 NC_012959 4014 4015 8391 12767 17143 21519 25895 30271 34647 40297 NC_012959 4015 4016 8392 12768 17144 21520 25896 30272 34648 40298 NC_012959 4016 4017 8393 12769 17145 21521 25897 30273 34649 37651 NC_012959 4017 4018 8394 12770 17146 21522 25898 30274 34650 37652 40299 NC_012959 4018 4019 8395 12771 17147 21523 25899 30275 34651 37653 40300 NC_012959 4019 4020 8396 12772 17148 21524 25900 30276 34652 37654 NC_012959 4020 4021 8397 12773 17149 21525 25901 30277 34653 37655 NC_012959 4021 4022 8398 12774 17150 21526 25902 30278 34654 37656 40301 NC_012959 4022 4023 8399 12775 17151 21527 25903 30279 34655 37657 40302 NC_012959 4023 4024 8400 12776 17152 21528 25904 30280 34656 37658 NC_012959 4024 4025 8401 12777 17153 21529 25905 30281 34657 37659 40303 NC_012959 4025 4026 8402 12778 17154 21530 25906 30282 34658 40304 NC_012959 4026 4027 8403 12779 17155 21531 25907 30283 34659 37660 NC_012959 4027 4028 8404 12780 17156 21532 25908 30284 34660 37661 40305 NC_012959 4028 4029 8405 12781 17157 21533 25909 30285 34661 40306 NC_012959 4029 4030 8406 12782 17158 21534 25910 30286 34662 37662 40307 NC_012959 4030 4031 8407 12783 17159 21535 25911 30287 34663 37663 NC_012959 4031 4032 8408 12784 17160 21536 25912 30288 34664 40308 NC_012959 4032 4033 8409 12785 17161 21537 25913 30289 34665 37664 40309 NC_012959 4033 4034 8410 12786 17162 21538 25914 30290 34666 37665 40310 NC_012959 4034 4035 8411 12787 17163 21539 25915 30291 34667 37666 NC_012959 4035 4036 8412 12788 17164 21540 25916 30292 34668 37667 40311 NC_012959 4036 4037 8413 12789 17165 21541 25917 30293 34669 37668 40312 NC_012959 4037 4038 8414 12790 17166 21542 25918 30294 34670 40313 NC_012959 4038 4039 8415 12791 17167 21543 25919 30295 34671 40314 NC_012959 4039 4040 8416 12792 17168 21544 25920 30296 34672 37669 NC_012959 4040 4041 8417 12793 17169 21545 25921 30297 34673 37670 NC_012959 4041 4042 8418 12794 17170 21546 25922 30298 34674 37671 NC_012959 4042 4043 8419 12795 17171 21547 25923 30299 34675 37672 40315 NC_012959 4043 4044 8420 12796 17172 21548 25924 30300 34676 37673 NC_012959 4044 4045 8421 12797 17173 21549 25925 30301 34677 40316 NC_012959 4045 4046 8422 12798 17174 21550 25926 30302 34678 37674 NC_012959 4046 4047 8423 12799 17175 21551 25927 30303 34679 37675 NC_012959 4047 4048 8424 12800 17176 21552 25928 30304 34680 40317 NC_012959 4048 4049 8425 12801 17177 21553 25929 30305 34681 37676 40318 NC_012959 4049 4050 8426 12802 17178 21554 25930 30306 34682 37677 NC_012959 4050 4051 8427 12803 17179 21555 25931 30307 34683 40319 NC_012959 4051 4052 8428 12804 17180 21556 25932 30308 34684 37678 40320 NC_012959 4052 4053 8429 12805 17181 21557 25933 30309 34685 40321 NC_012959 4053 4054 8430 12806 17182 21558 25934 30310 34686 37679 NC_012959 4054 4055 8431 12807 17183 21559 25935 30311 34687 37680 NC_012959 4055 4056 8432 12808 17184 21560 25936 30312 34688 37681 NC_012959 4056 4057 8433 12809 17185 21561 25937 30313 34689 37682 NC_012959 4057 4058 8434 12810 17186 21562 25938 30314 34690 40322 NC_012959 4058 4059 8435 12811 17187 21563 25939 30315 34691 37683 NC_012959 4059 4060 8436 12812 17188 21564 25940 30316 34692 37684 40323 NC_012959 4060 4061 8437 12813 17189 21565 25941 30317 34693 40324 NC_012959 4061 4062 8438 12814 17190 21566 25942 30318 34694 40325 NC_012959 4062 4063 8439 12815 17191 21567 25943 30319 34695 40326 NC_012959 4063 4064 8440 12816 17192 21568 25944 30320 34696 40327 NC_012959 4064 4065 8441 12817 17193 21569 25945 30321 34697 37685 NC_012959 4065 4066 8442 12818 17194 21570 25946 30322 34698 37686 40328 NC_012959 4066 4067 8443 12819 17195 21571 25947 30323 34699 37687 NC_012959 4067 4068 8444 12820 17196 21572 25948 30324 34700 40329 NC_012959 4068 4069 8445 12821 17197 21573 25949 30325 34701 40330 NC_012959 4069 4070 8446 12822 17198 21574 25950 30326 34702 40331 NC_012959 4070 4071 8447 12823 17199 21575 25951 30327 34703 37688 40332 NC_012959 4071 4072 8448 12824 17200 21576 25952 30328 34704 40333 NC_012959 4072 4073 8449 12825 17201 21577 25953 30329 34705 37689 NC_012959 4073 4074 8450 12826 17202 21578 25954 30330 34706 37690 NC_012959 4074 4075 8451 12827 17203 21579 25955 30331 34707 40334 NC_012959 4075 4076 8452 12828 17204 21580 25956 30332 34708 40335 NC_012959 4076 4077 8453 12829 17205 21581 25957 30333 34709 37691 NC_012959 4077 4078 8454 12830 17206 21582 25958 30334 34710 40336 NC_012959 4078 4079 8455 12831 17207 21583 25959 30335 34711 37692 NC_012959 4079 4080 8456 12832 17208 21584 25960 30336 34712 40337 NC_012959 4080 4081 8457 12833 17209 21585 25961 30337 34713 40338 NC_012959 4081 4082 8458 12834 17210 21586 25962 30338 34714 37693 NC_012959 4082 4083 8459 12835 17211 21587 25963 30339 34715 37694 NC_012959 4083 4084 8460 12836 17212 21588 25964 30340 34716 40339 NC_012959 4084 4085 8461 12837 17213 21589 25965 30341 34717 40340 NC_012959 4085 4086 8462 12838 17214 21590 25966 30342 34718 37695 NC_012959 4086 4087 8463 12839 17215 21591 25967 30343 34719 37696 40341 NC_012959 4087 4088 8464 12840 17216 21592 25968 30344 34720 37697 NC_012959 4088 4089 8465 12841 17217 21593 25969 30345 34721 37698 40342 NC_012959 4089 4090 8466 12842 17218 21594 25970 30346 34722 37699 NC_012959 4090 4091 8467 12843 17219 21595 25971 30347 34723 37700 NC_012959 4091 4092 8468 12844 17220 21596 25972 30348 34724 40343 NC_012959 4092 4093 8469 12845 17221 21597 25973 30349 34725 37701 40344 NC_012959 4093 4094 8470 12846 17222 21598 25974 30350 34726 40345 NC_012959 4094 4095 8471 12847 17223 21599 25975 30351 34727 37702 40346 NC_012959 4095 4096 8472 12848 17224 21600 25976 30352 34728 37703 40347 NC_012959 4096 4097 8473 12849 17225 21601 25977 30353 34729 37704 40348 NC_012959 4097 4098 8474 12850 17226 21602 25978 30354 34730 37705 NC_012959 4098 4099 8475 12851 17227 21603 25979 30355 34731 37706 40349 NC_003461 4099 4100 8476 12852 17228 21604 25980 30356 34732 40350 NC_003461 4100 4101 8477 12853 17229 21605 25981 30357 34733 37707 40351 NC_003461 4101 4102 8478 12854 17230 21606 25982 30358 34734 37708 NC_003461 4102 4103 8479 12855 17231 21607 25983 30359 34735 40352 NC_003461 4103 4104 8480 12856 17232 21608 25984 30360 34736 37709 NC_003461 4104 4105 8481 12857 17233 21609 25985 30361 34737 40353 NC_003461 4105 4106 8482 12858 17234 21610 25986 30362 34738 40354 NC_003461 4106 4107 8483 12859 17235 21611 25987 30363 34739 37710 40355 NC_003461 4107 4108 8484 12860 17236 21612 25988 30364 34740 37711 40356 NC_003461 4108 4109 8485 12861 17237 21613 25989 30365 34741 40357 NC_003461 4109 4110 8486 12862 17238 21614 25990 30366 34742 37712 NC_003461 4110 4111 8487 12863 17239 21615 25991 30367 34743 37713 NC_003461 4111 4112 8488 12864 17240 21616 25992 30368 34744 37714 40358 NC_003461 4112 4113 8489 12865 17241 21617 25993 30369 34745 37715 NC_003461 4113 4114 8490 12866 17242 21618 25994 30370 34746 37716 NC_003461 4114 4115 8491 12867 17243 21619 25995 30371 34747 40359 NC_003461 4115 4116 8492 12868 17244 21620 25996 30372 34748 40360 NC_003461 4116 4117 8493 12869 17245 21621 25997 30373 34749 37717 NC_003461 4117 4118 8494 12870 17246 21622 25998 30374 34750 37718 NC_003461 4118 4119 8495 12871 17247 21623 25999 30375 34751 40361 NC_003461 4119 4120 8496 12872 17248 21624 26000 30376 34752 40362 NC_003461 4120 4121 8497 12873 17249 21625 26001 30377 34753 37719 NC_003461 4121 4122 8498 12874 17250 21626 26002 30378 34754 40363 NC_003461 4122 4123 8499 12875 17251 21627 26003 30379 34755 37720 NC_003461 4123 4124 8500 12876 17252 21628 26004 30380 34756 37721 NC_003461 4124 4125 8501 12877 17253 21629 26005 30381 34757 40364 NC_003461 4125 4126 8502 12878 17254 21630 26006 30382 34758 37722 NC_003461 4126 4127 8503 12879 17255 21631 26007 30383 34759 37723 NC_003461 4127 4128 8504 12880 17256 21632 26008 30384 34760 40365 NC_003461 4128 4129 8505 12881 17257 21633 26009 30385 34761 37724 NC_003461 4129 4130 8506 12882 17258 21634 26010 30386 34762 37725 NC_003461 4130 4131 8507 12883 17259 21635 26011 30387 34763 40366 NC_003461 4131 4132 8508 12884 17260 21636 26012 30388 34764 37726 NC_003461 4132 4133 8509 12885 17261 21637 26013 30389 34765 40367 NC_007375 4133 4134 8510 12886 17262 21638 26014 30390 34766 37727 NC_007375 4134 4135 8511 12887 17263 21639 26015 30391 34767 37728 40368 NC_007375 4135 4136 8512 12888 17264 21640 26016 30392 34768 37729 NC_007375 4136 4137 8513 12889 17265 21641 26017 30393 34769 37730 NC_007375 4137 4138 8514 12890 17266 21642 26018 30394 34770 40369 NC_007375 4138 4139 8515 12891 17267 21643 26019 30395 34771 37731 NC_007375 4139 4140 8516 12892 17268 21644 26020 30396 34772 40370 NC_007375 4140 4141 8517 12893 17269 21645 26021 30397 34773 37732 NC_007375 4141 4142 8518 12894 17270 21646 26022 30398 34774 40371 NC_001694 4142 4143 8519 12895 17271 21647 26023 30399 34775 37733 40372 NC_001694 4143 4144 8520 12896 17272 21648 26024 30400 34776 37734 NC_001694 4144 4145 8521 12897 17273 21649 26025 30401 34777 40373 NC_001694 4145 4146 8522 12898 17274 21650 26026 30402 34778 40374 NC_001694 4146 4147 8523 12899 17275 21651 26027 30403 34779 37735 40375 NC_001694 4147 4148 8524 12900 17276 21652 26028 30404 34780 37736 NC_001694 4148 4149 8525 12901 17277 21653 26029 30405 34781 37737 NC_001694 4149 4150 8526 12902 17278 21654 26030 30406 34782 37738 NC_001694 4150 4151 8527 12903 17279 21655 26031 30407 34783 37739 NC_001694 4151 4152 8528 12904 17280 21656 26032 30408 34784 37740 NC_001694 4152 4153 8529 12905 17281 21657 26033 30409 34785 37741 NC_001694 4153 4154 8530 12906 17282 21658 26034 30410 34786 40376 NC_001694 4154 4155 8531 12907 17283 21659 26035 30411 34787 37742 NC_001694 4155 4156 8532 12908 17284 21660 26036 30412 34788 37743 40377 NC_001694 4156 4157 8533 12909 17285 21661 26037 30413 34789 37744 NC_001694 4157 4158 8534 12910 17286 21662 26038 30414 34790 40378 NC_001694 4158 4159 8535 12911 17287 21663 26039 30415 34791 40379 NC_001694 4159 4160 8536 12912 17288 21664 26040 30416 34792 37745 NC_001694 4160 4161 8537 12913 17289 21665 26041 30417 34793 40380 NC_001694 4161 4162 8538 12914 17290 21666 26042 30418 34794 40381 NC_001694 4162 4163 8539 12915 17291 21667 26043 30419 34795 37746 40382 NC_009333 4163 4164 8540 12916 17292 21668 26044 30420 34796 40383 NC_009333 4164 4165 8541 12917 17293 21669 26045 30421 34797 40384 NC_009333 4165 4166 8542 12918 17294 21670 26046 30422 34798 40385 NC_009333 4166 4167 8543 12919 17295 21671 26047 30423 34799 37747 40386 NC_009333 4167 4168 8544 12920 17296 21672 26048 30424 34800 37748 40387 NC_009333 4168 4169 8545 12921 17297 21673 26049 30425 34801 40388 NC_009333 4169 4170 8546 12922 17298 21674 26050 30426 34802 37749 40389 NC_009333 4170 4171 8547 12923 17299 21675 26051 30427 34803 37750 40390 NC_009333 4171 4172 8548 12924 17300 21676 26052 30428 34804 37751 40391 NC_009333 4172 4173 8549 12925 17301 21677 26053 30429 34805 40392 NC_009333 4173 4174 8550 12926 17302 21678 26054 30430 34806 40393 NC_009333 4174 4175 8551 12927 17303 21679 26055 30431 34807 40394 NC_009333 4175 4176 8552 12928 17304 21680 26056 30432 34808 37752 NC_009333 4176 4177 8553 12929 17305 21681 26057 30433 34809 40395 NC_009333 4177 4178 8554 12930 17306 21682 26058 30434 34810 40396 NC_009333 4178 4179 8555 12931 17307 21683 26059 30435 34811 37753 NC_009333 4179 4180 8556 12932 17308 21684 26060 30436 34812 37754 NC_009333 4180 4181 8557 12933 17309 21685 26061 30437 34813 37755 40397 NC_009333 4181 4182 8558 12934 17310 21686 26062 30438 34814 37756 40398 NC_009333 4182 4183 8559 12935 17311 21687 26063 30439 34815 37757 40399 NC_009333 4183 4184 8560 12936 17312 21688 26064 30440 34816 40400 NC_009333 4184 4185 8561 12937 17313 21689 26065 30441 34817 37758 NC_009333 4185 4186 8562 12938 17314 21690 26066 30442 34818 40401 NC_009333 4186 4187 8563 12939 17315 21691 26067 30443 34819 37759 NC_009333 4187 4188 8564 12940 17316 21692 26068 30444 34820 37760 NC_009333 4188 4189 8565 12941 17317 21693 26069 30445 34821 37761 NC_009333 4189 4190 8566 12942 17318 21694 26070 30446 34822 37762 40402 NC_009333 4190 4191 8567 12943 17319 21695 26071 30447 34823 37763 40403 NC_009333 4191 4192 8568 12944 17320 21696 26072 30448 34824 37764 NC_009333 4192 4193 8569 12945 17321 21697 26073 30449 34825 37765 NC_009333 4193 4194 8570 12946 17322 21698 26074 30450 34826 37766 NC_009333 4194 4195 8571 12947 17323 21699 26075 30451 34827 37767 40404 NC_009333 4195 4196 8572 12948 17324 21700 26076 30452 34828 37768 NC_009333 4196 4197 8573 12949 17325 21701 26077 30453 34829 37769 40405 NC_009333 4197 4198 8574 12950 17326 21702 26078 30454 34830 37770 NC_009333 4198 4199 8575 12951 17327 21703 26079 30455 34831 37771 40406 NC_009333 4199 4200 8576 12952 17328 21704 26080 30456 34832 37772 40407 NC_009333 4200 4201 8577 12953 17329 21705 26081 30457 34833 37773 40408 NC_009333 4201 4202 8578 12954 17330 21706 26082 30458 34834 37774 40409 NC_009333 4202 4203 8579 12955 17331 21707 26083 30459 34835 37775 40410 NC_009333 4203 4204 8580 12956 17332 21708 26084 30460 34836 37776 40411 NC_001352 4204 4205 8581 12957 17333 21709 26085 30461 34837 37777 40412 NC_001352 4205 4206 8582 12958 17334 21710 26086 30462 34838 40413 NC_001352 4206 4207 8583 12959 17335 21711 26087 30463 34839 40414 NC_001352 4207 4208 8584 12960 17336 21712 26088 30464 34840 40415 NC_001352 4208 4209 8585 12961 17337 21713 26089 30465 34841 37778 NC_001352 4209 4210 8586 12962 17338 21714 26090 30466 34842 40416 NC_001352 4210 4211 8587 12963 17339 21715 26091 30467 34843 37779 NC_001352 4211 4212 8588 12964 17340 21716 26092 30468 34844 37780 40417 NC_001352 4212 4213 8589 12965 17341 21717 26093 30469 34845 37781 NC_001352 4213 4214 8590 12966 17342 21718 26094 30470 34846 37782 NC_001352 4214 4215 8591 12967 17343 21719 26095 30471 34847 37783 40418 NC_001352 4215 4216 8592 12968 17344 21720 26096 30472 34848 40419 NC_001352 4216 4217 8593 12969 17345 21721 26097 30473 34849 40420 NC_001352 4217 4218 8594 12970 17346 21722 26098 30474 34850 37784 40421 NC_001352 4218 4219 8595 12971 17347 21723 26099 30475 34851 40422 NC_001352 4219 4220 8596 12972 17348 21724 26100 30476 34852 40423 NC_014956 4220 4221 8597 12973 17349 21725 26101 30477 34853 37785 NC_014956 4221 4222 8598 12974 17350 21726 26102 30478 34854 37786 40424 NC_014956 4222 4223 8599 12975 17351 21727 26103 30479 34855 37787 NC_014956 4223 4224 8600 12976 17352 21728 26104 30480 34856 37788 NC_014956 4224 4225 8601 12977 17353 21729 26105 30481 34857 37789 40425 NC_014956 4225 4226 8602 12978 17354 21730 26106 30482 34858 40426 NC_014956 4226 4227 8603 12979 17355 21731 26107 30483 34859 37790 NC_014956 4227 4228 8604 12980 17356 21732 26108 30484 34860 37791 NC_014956 4228 4229 8605 12981 17357 21733 26109 30485 34861 40427 NC_014956 4229 4230 8606 12982 17358 21734 26110 30486 34862 37792 NC_014956 4230 4231 8607 12983 17359 21735 26111 30487 34863 37793 NC_014956 4231 4232 8608 12984 17360 21736 26112 30488 34864 40428 NC_014956 4232 4233 8609 12985 17361 21737 26113 30489 34865 37794 NC_014956 4233 4234 8610 12986 17362 21738 26114 30490 34866 37795 NC_014956 4234 4235 8611 12987 17363 21739 26115 30491 34867 40429 NC_017995 4235 4236 8612 12988 17364 21740 26116 30492 34868 37796 NC_017995 4236 4237 8613 12989 17365 21741 26117 30493 34869 40430 NC_017995 4237 4238 8614 12990 17366 21742 26118 30494 34870 37797 40431 NC_017995 4238 4239 8615 12991 17367 21743 26119 30495 34871 37798 NC_017995 4239 4240 8616 12992 17368 21744 26120 30496 34872 37799 NC_017995 4240 4241 8617 12993 17369 21745 26121 30497 34873 37800 NC_017995 4241 4242 8618 12994 17370 21746 26122 30498 34874 40432 NC_017995 4242 4243 8619 12995 17371 21747 26123 30499 34875 37801 NC_017995 4243 4244 8620 12996 17372 21748 26124 30500 34876 37802 NC_017995 4244 4245 8621 12997 17373 21749 26125 30501 34877 40433 NC_017995 4245 4246 8622 12998 17374 21750 26126 30502 34878 37803 NC_017995 4246 4247 8623 12999 17375 21751 26127 30503 34879 37804 NC_017995 4247 4248 8624 13000 17376 21752 26128 30504 34880 37805 NC_017995 4248 4249 8625 13001 17377 21753 26129 30505 34881 37806 NC_017995 4249 4250 8626 13002 17378 21754 26130 30506 34882 37807 NC_002209 4250 4251 8627 13003 17379 21755 26131 30507 34883 37808 NC_002209 4251 4252 8628 13004 17380 21756 26132 30508 34884 37809 40434 NC_002209 4252 4253 8629 13005 17381 21757 26133 30509 34885 37810 NC_002209 4253 4254 8630 13006 17382 21758 26134 30510 34886 40435 NC_002209 4254 4255 8631 13007 17383 21759 26135 30511 34887 37811 40436 NC_002209 4255 4256 8632 13008 17384 21760 26136 30512 34888 40437 NC_001591 4256 4257 8633 13009 17385 21761 26137 30513 34889 37812 NC_001591 4257 4258 8634 13010 17386 21762 26138 30514 34890 40438 NC_001591 4258 4259 8635 13011 17387 21763 26139 30515 34891 40439 NC_001591 4259 4260 8636 13012 17388 21764 26140 30516 34892 37813 NC_001591 4260 4261 8637 13013 17389 21765 26141 30517 34893 40440 NC_001591 4261 4262 8638 13014 17390 21766 26142 30518 34894 40441 NC_001591 4262 4263 8639 13015 17391 21767 26143 30519 34895 40442 NC_001591 4263 4264 8640 13016 17392 21768 26144 30520 34896 37814 NC_001591 4264 4265 8641 13017 17393 21769 26145 30521 34897 37815 40443 NC_001591 4265 4266 8642 13018 17394 21770 26146 30522 34898 37816 NC_001591 4266 4267 8643 13019 17395 21771 26147 30523 34899 37817 NC_001591 4267 4268 8644 13020 17396 21772 26148 30524 34900 40444 NC_001591 4268 4269 8645 13021 17397 21773 26149 30525 34901 37818 NC_001591 4269 4270 8646 13022 17398 21774 26150 30526 34902 37819 NC_001591 4270 4271 8647 13023 17399 21775 26151 30527 34903 37820 NC_001591 4271 4272 8648 13024 17400 21776 26152 30528 34904 37821 NC_001591 4272 4273 8649 13025 17401 21777 26153 30529 34905 37822 NC_001591 4273 4274 8650 13026 17402 21778 26154 30530 34906 40445 NC_001591 4274 4275 8651 13027 17403 21779 26155 30531 34907 37823 NC_026428 4275 4276 8652 13028 17404 21780 26156 30532 34908 37824 NC_006309 4276 4277 8653 13029 17405 21781 26157 30533 34909 37825 NC_006309 4277 4278 8654 13030 17406 21782 26158 30534 34910 37826 NC_016157 4278 4279 8655 13031 17407 21783 26159 30535 34911 37827 NC_016157 4279 4280 8656 13032 17408 21784 26160 30536 34912 37828 NC_016157 4280 4281 8657 13033 17409 21785 26161 30537 34913 40446 NC_016157 4281 4282 8658 13034 17410 21786 26162 30538 34914 40447 NC_016157 4282 4283 8659 13035 17411 21787 26163 30539 34915 40448 NC_016157 4283 4284 8660 13036 17412 21788 26164 30540 34916 37829 NC_016157 4284 4285 8661 13037 17413 21789 26165 30541 34917 37830 NC_016157 4285 4286 8662 13038 17414 21790 26166 30542 34918 37831 NC_016157 4286 4287 8663 13039 17415 21791 26167 30543 34919 40449 NC_016157 4287 4288 8664 13040 17416 21792 26168 30544 34920 37832 NC_014952 4288 4289 8665 13041 17417 21793 26169 30545 34921 40450 NC_014952 4289 4290 8666 13042 17418 21794 26170 30546 34922 37833 NC_014952 4290 4291 8667 13043 17419 21795 26171 30547 34923 37834 40451 NC_014952 4291 4292 8668 13044 17420 21796 26172 30548 34924 40452 NC_014952 4292 4293 8669 13045 17421 21797 26173 30549 34925 40453 NC_014952 4293 4294 8670 13046 17422 21798 26174 30550 34926 37835 NC_014952 4294 4295 8671 13047 17423 21799 26175 30551 34927 40454 NC_014952 4295 4296 8672 13048 17424 21800 26176 30552 34928 37836 40455 NC_014952 4296 4297 8673 13049 17425 21801 26177 30553 34929 37837 NC_014952 4297 4298 8674 13050 17426 21802 26178 30554 34930 37838 NC_014952 4298 4299 8675 13051 17427 21803 26179 30555 34931 37839 NC_014952 4299 4300 8676 13052 17428 21804 26180 30556 34932 37840 NC_014952 4300 4301 8677 13053 17429 21805 26181 30557 34933 37841 NC_017997 4301 4302 8678 13054 17430 21806 26182 30558 34934 40456 NC_017997 4302 4303 8679 13055 17431 21807 26183 30559 34935 37842 40457 NC_017997 4303 4304 8680 13056 17432 21808 26184 30560 34936 37843 NC_017997 4304 4305 8681 13057 17433 21809 26185 30561 34937 40458 NC_017997 4305 4306 8682 13058 17434 21810 26186 30562 34938 37844 40459 NC_017997 4306 4307 8683 13059 17435 21811 26187 30563 34939 37845 NC_017997 4307 4308 8684 13060 17436 21812 26188 30564 34940 37846 NC_017997 4308 4309 8685 13061 17437 21813 26189 30565 34941 40460 NC_017997 4309 4310 8686 13062 17438 21814 26190 30566 34942 40461 NC_017997 4310 4311 8687 13063 17439 21815 26191 30567 34943 40462 NC_017997 4311 4312 8688 13064 17440 21816 26192 30568 34944 37847 NC_017997 4312 4313 8689 13065 17441 21817 26193 30569 34945 37848 40463 NC_017997 4313 4314 8690 13066 17442 21818 26194 30570 34946 40464 NC_017997 4314 4315 8691 13067 17443 21819 26195 30571 34947 37849 40465 NC_007369 4315 4316 8692 13068 17444 21820 26196 30572 34948 40466 NC_007369 4316 4317 8693 13069 17445 21821 26197 30573 34949 37850 40467 NC_007369 4317 4318 8694 13070 17446 21822 26198 30574 34950 37851 NC_007369 4318 4319 8695 13071 17447 21823 26199 30575 34951 40468 NC_038889 4319 4320 8696 13072 17448 21824 26200 30576 34952 40469 NC_038889 4320 4321 8697 13073 17449 21825 26201 30577 34953 40470 NC_038889 4321 4322 8698 13074 17450 21826 26202 30578 34954 40471 NC_038889 4322 4323 8699 13075 17451 21827 26203 30579 34955 37852 NC_038889 4323 4324 8700 13076 17452 21828 26204 30580 34956 37853 NC_038889 4324 4325 8701 13077 17453 21829 26205 30581 34957 37854 NC_038889 4325 4326 8702 13078 17454 21830 26206 30582 34958 40472 NC_038889 4326 4327 8703 13079 17455 21831 26207 30583 34959 40473 NC_038889 4327 4328 8704 13080 17456 21832 26208 30584 34960 40474 NC_038889 4328 4329 8705 13081 17457 21833 26209 30585 34961 37855 40475 NC_038889 4329 4330 8706 13082 17458 21834 26210 30586 34962 37856 40476 NC_038889 4330 4331 8707 13083 17459 21835 26211 30587 34963 40477 NC_038889 4331 4332 8708 13084 17460 21836 26212 30588 34964 40478 NC_038889 4332 4333 8709 13085 17461 21837 26213 30589 34965 37857 NC_038889 4333 4334 8710 13086 17462 21838 26214 30590 34966 37858 NC_038889 4334 4335 8711 13087 17463 21839 26215 30591 34967 37859 NC_038889 4335 4336 8712 13088 17464 21840 26216 30592 34968 37860 NC_038889 4336 4337 8713 13089 17465 21841 26217 30593 34969 37861 NC_001587 4337 4338 8714 13090 17466 21842 26218 30594 34970 37862 40479 NC_001587 4338 4339 8715 13091 17467 21843 26219 30595 34971 37863 NC_001587 4339 4340 8716 13092 17468 21844 26220 30596 34972 37864 NC_001587 4340 4341 8717 13093 17469 21845 26221 30597 34973 37865 NC_001587 4341 4342 8718 13094 17470 21846 26222 30598 34974 37866 NC_001587 4342 4343 8719 13095 17471 21847 26223 30599 34975 40480 NC_001587 4343 4344 8720 13096 17472 21848 26224 30600 34976 37867 NC_001587 4344 4345 8721 13097 17473 21849 26225 30601 34977 40481 NC_001587 4345 4346 8722 13098 17474 21850 26226 30602 34978 37868 NC_001587 4346 4347 8723 13099 17475 21851 26227 30603 34979 37869 NC_001587 4347 4348 8724 13100 17476 21852 26228 30604 34980 37870 NC_001587 4348 4349 8725 13101 17477 21853 26229 30605 34981 40482 NC_001587 4349 4350 8726 13102 17478 21854 26230 30606 34982 37871 40483 NC_001587 4350 4351 8727 13103 17479 21855 26231 30607 34983 40484 NC_007362 4351 4352 8728 13104 17480 21856 26232 30608 34984 37872 NC_007362 4352 4353 8729 13105 17481 21857 26233 30609 34985 37873 NC_007362 4353 4354 8730 13106 17482 21858 26234 30610 34986 40485 NC_007362 4354 4355 8731 13107 17483 21859 26235 30611 34987 40486 NC_007362 4355 4356 8732 13108 17484 21860 26236 30612 34988 40487 NC_007362 4356 4357 8733 13109 17485 21861 26237 30613 34989 37874 NC_007362 4357 4358 8734 13110 17486 21862 26238 30614 34990 37875 40488 NC_002019 4358 4359 8735 13111 17487 21863 26239 30615 34991 40489 NC_002019 4359 4360 8736 13112 17488 21864 26240 30616 34992 37876 NC_002019 4360 4361 8737 13113 17489 21865 26241 30617 34993 40490 NC_002019 4361 4362 8738 13114 17490 21866 26242 30618 34994 37877 NC_008189 4362 4363 8739 13115 17491 21867 26243 30619 34995 37878 NC_008189 4363 4364 8740 13116 17492 21868 26244 30620 34996 40491 NC_008189 4364 4365 8741 13117 17493 21869 26245 30621 34997 37879 NC_008189 4365 4366 8742 13118 17494 21870 26246 30622 34998 37880 NC_008189 4366 4367 8743 13119 17495 21871 26247 30623 34999 40492 NC_008189 4367 4368 8744 13120 17496 21872 26248 30624 35000 40493 NC_008189 4368 4369 8745 13121 17497 21873 26249 30625 35001 37881 40494 NC_008189 4369 4370 8746 13122 17498 21874 26250 30626 35002 37882 40495 NC_008189 4370 4371 8747 13123 17499 21875 26251 30627 35003 37883 NC_008189 4371 4372 8748 13124 17500 21876 26252 30628 35004 37884 NC_008189 4372 4373 8749 13125 17501 21877 26253 30629 35005 40496 NC_008189 4373 4374 8750 13126 17502 21878 26254 30630 35006 40497 NC_008189 4374 4375 8751 13127 17503 21879 26255 30631 35007 40498 NC_008189 4375 4376 8752 13128 17504 21880 26256 30632 35008 37885 40499

TABLE IB Index to LAMP Primer Descriptions Common Name % GC Accession Name Description NC_000117 41.30% NC_000117.1 Chlamydia trachomatis D/UW-3/CX chromosome, complete genome NC_001489 37.90% NC_001489.1 Hepatitis A virus, complete genome NC_003977 48.50% NC_003977.2 Hepatitis B virus (strain ayw) genome NC_038882 58.40% NC_038882.1 isolate H77 Hepatitis C virus (isolate H77) genotype 1, complete cds NC_004102 58.20% NC_004102.1 Hepatitis C virus genotype 1, complete genome NC_009823 56.90% NC_009823.1 Hepatitis C virus genotype 2, complete genome NC_009824 55.60% NC_009824.1 Hepatitis C virus genotype 3, genome NC_009825 56.20% NC_009825.1 Hepatitis C virus genotype 4, genome NC_009826 57.10% NC_009826.1 Hepatitis C virus genotype 5, genome NC_009827 55.40% NC_009827.1 Hepatitis C virus genotype 6, complete genome NC_030791 56.80% NC_030791.1 Hepatitis C virus genotype 7, complete genome NC_001653 58.80% NC_001653.2 Hepatitis delta virus, complete genome NC_001434 57.90% NC_001434.1 Hepatitis E virus, complete genome NC_038504 57.60% NC_038504.1 Hepatitis E virus rat/R63/DEU/2009, complete genome NC_001837 57.90% NC_001837.1 Hepatitis GB virus A, complete genome NC_001655 50.60% NC_001655.1 Hepatitis GB virus B, complete genome NC_012959 54.90% NC_012959.1 Human adenovirus 54, complete genome NC_001460 46.50% NC_001460.1 Human adenovirus A, complete genome NC_001664 42.40% NC_001664.4 Human betaherpesvirus 6A, variant A DNA, complete virion genome, isolate U1102 NC_002645 38.30% NC_002645.1 Human coronavirus 229E, complete genome NC_006577 32.10% NC_006577.2 HCoV-HKU1 Human coronavirus HKU1, complete genome NC_005831 34.50% NC_005831.2 HCoV-NL63 Human Coronavirus NL63, complete genome NC_006213 36.80% NC_006213.1 HCoV-OC43 Human coronavirus OC43 strain ATCC VR-759, complete genome NC_007605 59.50% NC_007605.1 Epstein-Barr Human gammaherpesvirus 4, complete genome virus NC_026817 54.90% NC_026817.1 Human genital-associated circular DNA virus-1 isolate 349, complete genome NC_001806 68.30% NC_001806.2 Herpes Human herpesvirus 1 strain 17, complete genome simplex virus 1 NC_001798 70.40% NC_001798.2 Herpes Human herpesvirus 2 strain HG52, complete simplex virus genome 2 NC_001348 46.00% NC_001348.1 HHV-3 Human herpesvirus 3, complete genome NC_009334 59.50% NC_009334.1 Epstein-Barr Human herpesvirus 4, complete genome virus type 2 NC_006273 57.50% NC_006273.2 HHV-5; HCMV Human herpesvirus 5 strain Merlin, complete genome NC_000898 42.80% NC_000898.1 HHV-6B Human herpesvirus 6B, complete genome NC_001716 36.20% NC_001716.2 HHV-7 Human herpesvirus 7, complete genome NC_009333 53.80% NC_009333.1 Kaposi's Human herpesvirus 8 strain GK18, complete sarcoma- genome associated herpesvirus NC_001802 42.10% NC_001802.1 HIV-1 Human immunodeficiency virus 1, complete genome NC_001722 45.70% NC_001722.1 HIV-2 Human immunodeficiency virus 2, complete genome NC_001676 41.90% NC_001676.1 Human papillomavirus 54, complete genome NC_013035 38.50% NC_013035.1 Human papillomavirus 116, complete genome NC_001356 40.30% NC_001356.1 Human papillomavirus-1, complete genome NC_001352 48.40% NC_001352.1 Human papillomavirus-2, complete genome NC_001357 40.40% NC_001357.1 Human papillomavirus-18, complete genome NC_001694 46.30% NC_001694.1 Human papillomavirus-61, complete genome NC_027779 37.50% NC_027779.1 Human papillomavirus isolate SE379, complete genome NC_026946 36.80% NC_026946.1 Human papillomavirus KC5, complete genome NC_001457 38.50% NC_001457.1 Human papillomavirus type 4, complete genome NC_001355 40.90% NC_001355.1 Human papillomavirus type 6b, complete genome NC_001595 39.50% NC_001595.1 Human papillomavirus type 7 genomic DNA NC_001596 41.00% NC_001596.1 Human papillomavirus type 9, complete genome NC_001576 45.90% NC_001576.1 Human papillomavirus type 10 genomic DNA NC_001526 36.50% NC_001526.4 Human papillomavirus type 16, complete genome NC_001583 38.60% NC_001583.1 Human papillomavirus type 26, complete genome NC_038889 40.40% NC_038889.1 Human papillomavirus type 30 genomic DNA NC_001586 41.00% NC_001586.1 Human papillomavirus type 32, complete genome NC_001587 38.20% NC_001587.1 Human papillomavirus type 34, complete genome NC_001354 46.90% NC_001354.1 Human papillomavirus type 41, complete genome NC_001690 36.80% NC_001690.1 Human papillomavirus type 48, complete genome NC_001591 41.10% NC_001591.1 Human papillomavirus type 49, complete genome NC_001691 36.80% NC_001691.1 Human papillomavirus type 50, complete genome NC_001593 40.10% NC_001593.1 Human papillomavirus type 53, complete genome NC_001693 37.00% NC_001693.1 Human papillomavirus type 60, complete genome NC_001458 40.40% NC_001458.1 Human papillomavirus type 63, complete genome NC_039089 44.40% NC_039089.1 Human papillomavirus type 71 DNA, complete genome NC_034616 37.70% NC_034616.1 Human papillomavirus type 85 isolate 114B, complete genome NC_010329 40.10% NC_010329.1 Human papillomavirus type 88, complete genome NC_004104 46.70% NC_004104.1 candHPV90 Human papillomavirus type 90, complete genome NC_004500 40.00% NC_004500.1 Human papillomavirus type 92, complete genome NC_005134 40.30% NC_005134.2 Human papillomavirus type 96, complete genome NC_008189 43.10% NC_008189.1 HPV101 Human papillomavirus type 101, complete genome NC_008188 41.60% NC_008188.1 HPV103 Human papillomavirus type 103, complete genome NC_012213 42.60% NC_012213.1 Human papillomavirus type 108, complete genome NC_012485 38.30% NC_012485.1 Human papillomavirus type 109, complete genome NC_012486 37.50% NC_012486.1 Human papillomavirus type 112, complete genome NC_014185 37.70% NC_014185.1 Human papillomavirus type 121, complete genome NC_016157 38.00% NC_016157.1 Human papillomavirus type 126, complete genome NC_014952 36.00% NC_014952.1 Human papillomavirus type 128, complete genome NC_014953 37.30% NC_014953.1 Human papillomavirus type 129, complete genome NC_014954 37.00% NC_014954.1 Human papillomavirus type 131, complete genome NC_014955 37.90% NC_014955.1 Human papillomavirus type 132, complete genome NC_014956 38.10% NC_014956.1 Human papillomavirus type 134, complete genome NC_017993 36.80% NC_017993.1 Human papillomavirus type 135, complete genome NC_017994 38.50% NC_017994.1 Human papillomavirus type 136, complete genome NC_017995 37.60% NC_017995.1 Human papillomavirus type 137, complete genome NC_017996 39.70% NC_017996.1 Human papillomavirus type 140, complete genome NC_017997 38.20% NC_017997.1 Human papillomavirus type 144, complete genome NC_021483 37.90% NC_021483.1 HPV154 Human papillomavirus type 154 isolate PV77, complete genome NC_033781 36.20% NC_033781.1 Human papillomavirus type 156 isolate GC01, complete genome NC_038522 37.70% NC_038522.1 Human papillomavirus type 161 isolate KC1, complete genome NC_028125 37.70% NC_028125.1 Human papillomavirus type 163 isolate KC3, complete genome NC_019023 38.30% NC_019023.1 Human papillomavirus type 166 isolate KC9, complete genome NC_022892 35.80% NC_022892.1 Human papillomavirus type 167 isolate KC10, complete genome NC_038523 37.80% NC_038523.1 HPV 172 Human papillomavirus type 172, complete genome NC_038524 38.90% NC_038524.1 Human papillomavirus type 175 isolate SE87, complete genome NC_023891 38.20% NC_023891.1 Human papillomavirus type 178, complete genome NC_022095 36.80% NC_022095.1 Human papillomavirus type 179 complete genome, isolate SIBX16 NC_038914 36.90% NC_038914.1 Human papillomavirus type 184 complete genome, isolate SIBX17 NC_039086 38.90% NC_039086.1 Human papillomavirus type 187 isolate ACS447, complete genome NC_027528 37.70% NC_027528.1 Human papillomavirus type 201 isolate HPV201, complete genome NC_038525 37.80% NC_038525.1 Human papillomavirus type 204 isolate A342, complete genome NC_001531 42.40% NC_001531.1 Human papillomoavirustype 5, complete genome NC_003461 37.20% NC_003461.1 Human parainfluenza virus 1, complete genome NC_001796 34.50% NC_001796.2 Human parainfluenza virus 3, complete genome NC_038311 37.40% NC_038311.1 HRV-Al Human rhinovirus 1 strain ATCC VR-1559, complete genome NC_038312 39.90% NC_038312.1 Human rhinovirus 3, complete genome NC_001490 40.60% NC_001490.1 Human rhinovirus 14, complete genome NC_001617 39.00% NC_001617.1 Human rhinovirus 89, complete genome NC_009996 42.80% NC_009996.1 Human rhinovirus C, complete genome NC_038878 43.40% NC_038878.1 Human rhinovirus NAT001 polyprotein gene, complete cds NC_001436 53.50% NC_001436.1 Human T-lymphotropic virus 1, complete genome NC_026438 44.80% NC_026438.1 A/California/ Influenza A virus (A/California/07/2009(H1N1)) 07/2009(H1N1 segment 1 polymerase PB2 (PB2) gene, complete cds NC_026435 42.00% NC_026435.1 A/California/ Influenza A virus (A/California/07/2009(H1N1)) 07/2009(H1N1 segment 2 polymerase PB1 (PB1) gene, complete cds; and nonfunctional PB1-F2 protein (PB1-F2) gene, complete sequence NC_026437 44.20% NC_026437.1 A/California/ Influenza A virus (A/California/07/2009(H1N1)) 07/2009(H1N1 segment 3 polymerase PA (PA) gene, complete cds NC_026433 40.80% NC_026433.1 A/California/ Influenza A virus (A/California/07/2009(H1N1)) 07/2009(H1N1 segment 4 hemagglutinin (HA) gene, complete cds NC_026436 46.30% NC_026436.1 A/California/ Influenza A virus (A/California/07/2009(H1N1)) 07/2009(H1N1 segment 5 nucleocapsid protein (NP) gene, complete cds NC_026434 42.10% NC_026434.1 A/California/ Influenza A virus (A/California/07/2009(H1N1)) 07/2009(H1N1 segment 6 neuraminidase (NA) gene, complete cds NC_026431 47.10% NC_026431.1 A/California/ Influenza A virus (A/California/07/2009(H1N1)) 07/2009(H1N1 segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes, complete cds NC_026432 43.60% NC_026432.1 A/California/ Influenza A virus (A/California/07/2009(H1N1)) 07/2009(H1N1 segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes, complete cds NC_007361 43.40% NC_007361.1 A/goose/ Influenza Avirus Guangdong/1/19 (A/Goose/Guangdong/1/96(H5N1)) 96(H5N1 neuraminidase (NA) gene, complete cds NC_007360 46.80% NC_007360.1 A/goose/ Influenza Avirus Guangdong/1/19 (A/Goose/Guangdong/1/96(H5N1)) nucleocapsid 96(H5N1 protein (NP) gene, complete cds NC_007357 44.30% NC_007357.1 A/goose/ Influenza Avirus Guangdong/1/19 (A/Goose/Guangdong/1/96(H5N1)) polymerase 96(H5N1 (PB2) gene, complete cds NC_007362 41.70% NC_007362.1 A/goose/ Influenza Avirus Guangdong/1/19 (A/goose/Guangdong/1/1996(H5N1)) 96(H5N1 hemagglutinin (HA) gene, complete cds NC_007359 43.80% NC_007359.1 A/goose/ Influenza Avirus Guangdong/1/19 (A/goose/Guangdong/1/1996(H5N1)) polymerase 96(H5N1 (PA) and PA-X protein (PA-X) genes, complete cds NC_007358 44.10% NC_007358.1 A/goose/ Influenza Avirus Guangdong/1/19 (A/goose/Guangdong/1/1996(H5N1)) polymerase 96(H5N1 (PB1) and PB1-F2 protein (PB1-F2) genes, complete cds NC_007363 47.90% NC_007363.1 A/goose/ Influenza Avirus Guangdong/1/19 (A/goose/Guangdong/1/1996(H5N1)) segment 7, 96(H5N1 complete sequence NC_007364 41.40% NC_007364.1 A/goose/ Influenza Avirus Guangdong/1/19 (A/goose/Guangdong/1/1996(H5N1)) segment 8, 96(H5N1 complete sequence NC_004905 47.30% NC_004905.2 A/Hong Influenza Avirus (A/Hong Kong/1073/99(H9N2)) Kong/1073/ segment 5, complete sequence 99(H9N2 NC_004907 47.80% NC_004907.1 A/Hong Influenza Avirus (A/Hong Kong/1073/99(H9N2)) Kong/1073/ segment 7, complete sequence 99(H9N2 NC_004906 43.30% NC_004906.1 A/Hong Influenza Avirus (A/Hong Kong/1073/99(H9N2)) Kong/1073/ segment 8, complete sequence 99(H9N2 NC_007378 42.50% NC_007378.1 A/Korea/426/ Influenza Avirus (A/Korea/426/1968(H2N2)) 1968(H2N2 segment 1, complete sequence NC_007375 42.70% NC_007375.1 A/Korea/426/ Influenza Avirus (A/Korea/426/1968(H2N2)) 1968(H2N2 segment 2, complete sequence NC_007376 42.40% NC_007376.1 A/Korea/426/ Influenza Avirus (A/Korea/426/1968(H2N2)) 1968(H2N2 segment 3, complete sequence NC_007374 41.60% NC_007374.1 A/Korea/426/ Influenza Avirus (A/Korea/426/1968(H2N2)) 1968(H2N2 segment 4, complete sequence NC_007381 46.40% NC_007381.1 A/Korea/426/ Influenza Avirus (A/Korea/426/1968(H2N2)) 1968(H2N2 segment 5, complete sequence NC_007382 43.40% NC_007382.1 A/Korea/426/ Influenza Avirus (A/Korea/426/1968(H2N2)) 1968(H2N2 segment 6, complete sequence NC_007377 47.50% NC_007377.1 A/Korea/426/ Influenza Avirus (A/Korea/426/1968(H2N2)) 1968(H2N2 segment 7, complete sequence NC_007380 43.40% NC_007380.1 A/Korea/426/ Influenza Avirus (A/Korea/426/1968(H2N2)) 1968(H2N2 segment 8, complete sequence NC_007373 42.50% NC_007373.1 A/New Influenza A virus (A/New York/392/2004(H3N2)) York/392/ segment 1, complete sequence 2004(H3N2 NC_007372 42.20% NC_007372.1 A/New Influenza A virus (A/New York/392/2004(H3N2)) York/392/ segment 2, complete sequence 2004(H3N2 NC_007371 41.70% NC_007371.1 A/New Influenza A virus (A/New York/392/2004(H3N2)) York/392/ segment 3, complete sequence 2004(H3N2 NC_007366 42.00% NC_007366.1 A/New Influenza A virus (A/New York/392/2004(H3N2)) York/392/ segment 4, complete sequence 2004(H3N2 NC_007369 45.80% NC_007369.1 A/New Influenza A virus (A/New York/392/2004(H3N2)) York/392/ segment 5, complete sequence 2004(H3N2 NC_007368 42.70% NC_007368.1 A/New Influenza A virus (A/New York/392/2004(H3N2)) York/392/ segment 6, complete sequence 2004(H3N2 NC_007367 46.70% NC_007367.1 A/New Influenza A virus (A/New York/392/2004(H3N2)) York/392/ segment 7, complete sequence 2004(H3N2 NC_007370 41.70% NC_007370.1 A/New Influenza A virus (A/New York/392/2004(H3N2)) York/392/ segment 8, complete sequence 2004(H3N2 NC_002023 43.70% NC_002023.1 A/Puerto Influenza Avirus (A/Puerto Rico/8/1934(H1N1)) Rico/8/1934 segment 1, complete sequence (H1N1 NC_002021 42.10% NC_002021.1 A/Puerto Influenza Avirus (A/Puerto Rico/8/1934(H1N1)) Rico/8/1934 segment 2, complete sequence (H1N1 NC_002022 42.00% NC_002022.1 A/Puerto Influenza Avirus (A/Puerto Rico/8/1934(H1N1)) Rico/8/1934 segment 3, complete sequence (H1N1 NC_002017 41.60% NC_002017.1 A/Puerto Influenza Avirus (A/Puerto Rico/8/1934(H1N1)) Rico/8/1934 segment 4, complete sequence (H1N1 NC_002019 46.40% NC_002019.1 A/Puerto Influenza Avirus (A/Puerto Rico/8/1934(H1N1)) Rico/8/1934 segment 5, complete sequence (H1N1 NC_002018 42.70% NC_002018.1 A/Puerto Influenza Avirus (A/Puerto Rico/8/1934(H1N1)) Rico/8/1934 segment 6, complete sequence (H1N1 NC_002016 47.20% NC_002016.1 A/Puerto Influenza Avirus (A/Puerto Rico/8/1934(H1N1)) Rico/8/1934 segment 7, complete sequence (H1N1 NC_002020 44.30% NC_002020.1 A/Puerto Influenza Avirus (A/Puerto Rico/8/1934(H1N1)) Rico/8/1934 segment 8, complete sequence (H1N1 NC_026422 44.90% NC_026422.1 A/Shanghai/ Influenza Avirus (A/Shanghai/02/2013(H7N9)) 02/2013(H7N9 segment 1 polymerase PB2 (PB2) gene, complete cds NC_026423 44.20% NC_026423.1 A/Shanghai/ Influenza Avirus (A/Shanghai/02/2013(H7N9)) 02/2013(H7N9 segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes, complete cds NC_026424 44.30% NC_026424.1 A/Shanghai/ Influenza Avirus (A/Shanghai/02/2013(H7N9)) 02/2013(H7N9 segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes, complete cds NC_026425 41.80% NC_026425.1 A/Shanghai/ Influenza Avirus (A/Shanghai/02/2013(H7N9)) 02/2013(H7N9 segment 4 hemagglutinin (HA) gene, complete cds NC_026426 46.60% NC_026426.1 A/Shanghai/ Influenza Avirus (A/Shanghai/02/2013(H7N9)) 02/2013(H7N9 segment 5 nucleocapsid protein (NP) gene, complete cds NC_026429 43.60% NC_026429.1 A/Shanghai/ Influenza Avirus (A/Shanghai/02/2013(H7N9)) 02/2013(H7N9 segment 6 neuraminidase (NA) gene, complete cds NC_026427 47.50% NC_026427.1 A/Shanghai/ Influenza Avirus (A/Shanghai/02/2013(H7N9)) 02/2013(H7N9 segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes, complete cds NC_026428 41.90% NC_026428.1 A/Shanghai/ Influenza Avirus (A/Shanghai/02/2013(H7N9)) 02/2013(H7N9 segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes, complete cds NC_004908 42.50% NC_004908.1 A/Hong Influenza Avirus ha gene for Hemagglutinin, Kong/1073/ genomic RNA, strain A/Hong 99(H9N2 Kong/1073/99(H9N2) NC_004909 42.60% NC_004909.1 A/Hong Influenza Avirus na gene for neuraminidase, Kong/1073/ genomic RNA, strain A/Hong 99(H9N2 Kong/1073/99(H9N2) NC_004912 44.00% NC_004912.1 A/Hong Influenza A virus pa gene for polymerase PA, Kong/1073/ genomic RNA, strain A/Hong 99(H9N2 Kong/1073/99(H9N2) NC_004911 43.50% NC_004911.1 A/Hong Influenza A virus pb1 gene for polymerase Pb1, Kong/1073/ genomic RNA, strain A/Hong 99(H9N2 Kong/1073/99(H9N2) NC_004910 43.20% NC_004910.1 A/Hong Influenza A virus pb2 gene for polymerase Pb2, Kong/1073/ genomic RNA, strain A/Hong 99(H9N2 Kong/1073/99(H9N2) NC_002205 38.50% NC_002205.1 B/Lee/1940 Influenza B virus (B/Lee/1940) segment 2, complete sequence NC_002206 39.20% NC_002206.1 B/Lee/1940 Influenza B virus (B/Lee/1940) segment 3, complete sequence NC_002207 41.80% NC_002207.1 B/Lee/1940 Influenza B virus (B/Lee/1940) segment 4, complete sequence NC_002208 42.00% NC_002208.1 B/Lee/1940 Influenza B virus (B/Lee/1940) segment 5, complete sequence NC_002209 41.60% NC_002209.1 B/Lee/1940 Influenza B virus (B/Lee/1940) segment 6, complete sequence NC_002210 38.80% NC_002210.1 B/Lee/1940 Influenza B virus (B/Lee/1940) segment 7, complete sequence NC_002211 41.30% NC_002211.1 B/Lee/1940 Influenza B virus (B/Lee/1940) segment 8, complete sequence NC_002204 39.10% NC_002204.1 B/Lee/1940 Influenza B virus RNA 1, complete sequence NC_006310 39.80% NC_006310.2 C/Ann Influenza C virus (C/Ann Arbor/1/50) HEF gene for Arbor/1/50 hemagglutinin-esterase-fusion, complete cds NC_006312 38.60% NC_006312.2 C/Ann Influenza C virus (C/Ann Arbor/1/50) M1, CM2 Arbor/1/50 genes for matrix protein, CM2 protein, complete cds NC_006309 35.60% NC_006309.2 C/Ann Influenza C virus (C/Ann Arbor/1/50) P3 gene for Arbor/1/50 polymerase 3, complete cds NC_006308 35.60% NC_006308.2 C/Ann Influenza C virus (C/Ann Arbor/1/50) PB1 gene for Arbor/1/50 polymerase 1, complete cds NC_006307 36.80% NC_006307.2 C/Ann Influenza C virus (C/Ann Arbor/1/50) PB2 gene for Arbor/1/50 polymerase 2, complete cds NC_006311 38.40% NC_006311.1 C/Ann Influenza C virus (C/Ann Arbor/1/50) segment 5, Arbor/1/50 complete sequence NC_006306 37.50% NC_006306.2 C/Ann Influenza C virus (C/Ann Arbor/1/50) segment 7, Arbor/1/50 complete sequence NZ_LT591897 52.10% NZ_LT591897.1 Neisseria gonorrhoeae strain WHO F chromosome 1 NC_001803 33.20% NC_001803.1 Respiratory syncytial virus, complete genome NC_004718 40.80% NC_004718.3 SARS coronavirus, complete genome NZ_LN831034 38.50% NZ_LN831034.1 Streptococcus pyogenes strain NCTC8198 chromosome 1

In certain example embodiments, the LAMP amplification reagents may include primers to SARS-COV2. In certain example embodiments, the primers are selected from SEQ ID NOS: 1-40,499 from Table 5, Table 10, Table 15. LAMP reagents may further comprise colorimetric and/or fluorescent detection reagents, such as hydroxy napthol blue (see, e.g. Goto, M., et al., Colorimetric detection of loop-mediated isothermal amplification reaction by using hydroxy naphthol blue. Biotechniques, 2009. 46 (3): p. 167-72.) leuco triphenylmethane dyes (see, e.g. Miyamoto, S., et al., Method for colorimetric detection of double-stranded nucleic acid using leuco triphenylmethane dyes. Anal Biochem, 2015. 473: p. 28-33) and pH-sensitive dyes (see, e.g. Tanner, N. A., Y. Zhang, and T. C. Evans, Jr., Visual detection of isothermal nucleic acid amplification using pH-sensitive dyes. Biotechniques, 2015. 58 (2): p. 59-68); as well as fluorescent detection (see, e.g. Yu et al., Clinical Chemistry, hvaa102, doi:10.1093/clinchem/hvaa102 12 May 2020), including use of quenching probes (see, e.g. Shirato et al., J Virol Methods. 2018 August; 258:41-48. doi: 10.1016/j.jviromet.2018.05.006). An overview of LAMP methods, including OSD-LAMP, for sequence-specific detection is described in Becherer et al., Anal. Methods, 2020, 12, 717-746, doi: 10.1039/C9AY02246E, incorporated herein by reference.

In embodiments, the LAMP amplification reagents can comprise oligonucleotide strand displacement (OSD) probes. As used herein, oligonucleotide strand displacement probes are also referred to herein as oligonucleotide strand exchange probes or one-step strand displacement probes. The general concept of the use of OSD exchange is depicted in FIG. 1 of Bhadra et al., High-surety isothermal amplification and detection of SARS-CoV-2, including with crude enzymes, doi:10.1101/2020.04.13.039941. OSD probes rely on the binding enthalpy between the target-binding probe and amplicon of the LAMP reaction yielding a strand exchange reaction, leading to an easily read change in fluorescent signal. As a result, the results of a LAMP reaction can be visually or optically read fluorogenic OSD probes.

In an aspect, the OSD probes comprise a sequence specific for a target molecule. The OSD probes may comprise a pre-hybridized nucleic acid sequence, strand wherein the target sequence is 5, 6, 7, 8, 9, 10, 11, 12 or 13 nucleotides longer than the strand to which it is hybridized, allowing for sequence-specific interaction with a complementary target, with the OSD undergoing strand exchange and yielding a change in fluorescent signal. In a certain aspect, the OSD probes are designed specific for one or more of the LAMP primer sets disclosed herein, for example SEQ ID NOs. 1-40499, 61,983-61,988, Table 5, Table 10, Table 15. In an aspect the OSD probes are specific for LAMP primer N set 6. The OSD probes may be selected from Table 11. In an aspect, the OSD probes are provided at a concentration of about 50 nM to 200 nM, about 75 nM to 150 nM, less than or equal to 200 nM, 190 nM, 180 nM, 170 nM, 160 nM, 150 nM, 140 nM, 130 nM, 120 nM, 110 nM, 100 nM, 90 nM, 80 nM, 75 nM, 65 nM, or 50 nM. Probes can be designed to be complementary to the loop region between the F1c and F2 primer binding sites for the LAMP primers, this can be reffed to as the long toehold region. The complementary portion can be between about 9 and 14 nucleotides long, more preferably 11-12 nucleotides long. In an aspect, the longer strand of the OSD is labeled with a fluorescent molecule at the 5′ or 3′ end of the strand. In an aspect, the label is provided on the end opposite the designed complementary target region (long toehold region). The short strand is prepared with a quencher on one end of the probe, and can be designed to comprise a region complementary to a portion of the long strand. The OSD probes can be provided as part of LAMP reagents as described herein, which may comprise their use on any of the devices, cartridges or in any of the compositions as provided herein, including being provided as a lyophilized reagent in some instances.

In certain embodiments, extraction-free lysis solution and isothermal amplification reagents may be lyophilized in a single reaction volume, to be reconstituted by addition of a sample to be assayed. In certain other embodiments, the extraction-free lysis solution and and isothermal amplification reagents may be lyophilized and stored on a cartridge or lateral flow strip, as discussed in further detail below.

In certain example embodiments, the single lysis reaction compositions and kits may further comprise one or more Cas proteins possessing collateral activity and a detection construct. Pairing with one or more Cas proteins may increase sensitivity or specificity of the assay. In certain example embodiments, the one or more Cas proteins may be thermostable Cas proteins. Example Cas proteins are disclosed in further detail below.

In certain example embodiments, the single lysis amplification reaction compositions and kits may comprise optimized primers and/or one or more additives. In an aspect, the design optimizes the primers used in the amplification, In particular aspects, the isothermal amplification is used alone. In another aspect, the isothermal amplification is used with CRISPR-Cas systems comprising one or more Cas proteins and one or more guide molecules. In either approach, design considerations can follow a rational design for optimization of the reactions. Optimization of the methods as disclosed herein can include first screening primers to identify one or more sets of primers that work well for a particular target, Cas protein and/or reaction. Once the primers have been screened, titration of magnesium concentration can be performed to identify an optimal magnesium concentration for higher signal to noise readout. Once an optimum magnesium concentration is identified, additional additives are screened at around 20-25% of the reaction, and once additives are identified, these additives, such as those additives identified in FIG. 17 , can be evaluated and varied in concentration to identify optimal reaction kinetics for specific reaction parameters. In an example, varying additives with specific primers, target, Cas protein (when CRISPR system is used), temperature, and other additive concentrations within the reaction can be identified. Optimization can be made with the goal of reducing the number of steps and buffer exchanges that have to occur in the reaction, simplifying the reaction and reducing the risks of contamination at transfer steps. In an aspect, addition of inhibitors, such as proteinase K can be considered so that buffer exchanges can be reduced. Similarly, optimizing the salt levels as well as the type of salt utilized can further facilitate and optimize the one-pot detections disclosed herein. In an aspect, potassium chloride can be utilized rather than sodium choloride when such amplification approaches are used with bead concentration in a lysis step.

In certain embodiments, the compositions and kits may further comprise nucleic acid binding bead. The bead may be used to capture, concentrate or otherwise enrich for particular material. The bead may be magnetic, and may be provided to capture nucleic acid material. In another aspect, the bead is a silica bead. Beads may be utilized in an extraction step of the methods disclosed herein. Beads can be optionally used with the methods described herein, including with the one-pot methods that allow for concentration of viral nucleic acids from large volume samples, such as saliva or swab samples to allow for a single one-pot reaction method. Concentration of desired target molecules can be increased by about 10-fold, 50-fold, 100-fold, 200-fold, 500-fold, 800-fold, 1000-fold, 1500-fold, 2000-fold, 2500-fold, 3000-fold, or more.

Magnetic beads in a PEG and salt solution are preferred in an aspect, and in embodiments bind to viral RNA and/or DNA which allows for concentration and lysis concurrently. Silica beads can be used in another aspect. Capture moieties such as oligonucleotide functionalized beads are envisioned for use. The beads may be using with the extraction reagents, allowed to incubate with a sample and the lysis/extraction buffer, thereby concrrating target molecules on the beads. When used with a cartridge device detailed elsewhere herein, a magnet can be activated and the beads collected, with optional flushing of the extraction buffer and one or more washes performed. Advantageously, the beads can be used in the one-pot methods and systems without additional washings of the beads, allowing for a more efficient process without increased risks of contamination in multi-step processes. Beads can be utilized with the isothermal amplifications detailed herein, and the beads can flow into an amplification chamber of the cartridge or be maintained in the pot for the amplification step. Upon heating, nucleic acid can be released off the beads.

EXAMPLE CRISPR-CAS SYSTEMS

CRISPR Cas for use in the embodiments disclosed herein may comprise a Type V Cas protein, a Type VI Cas protein, or a combination thereof and one or more guide molecules. In certain embodiments, the Cas proteins are thermostable Cas proteins. Example thermostable Cas proteins can be selected from Table 2A or Table 2B, comprising Cas12 thermostable Cas proteins; other representative Cas12 and Cas13 proteins can be identified from Cas systems isolated from organisms that inhabit similar microenviroments. In certain example embodiments, the Cas is AapCas12b. In other example embodiments, the Cas is BrCas12b. In an aspect, two or more CRISPR effector systems are provided which may be RNA-targeting effector proteins, DNA-targeting effector proteins, or a combination thereof. The RNA-targeting effector proteins may be a Type VI Cas protein, such as Cas13 protein, including Cas13b, Cas13c, or Cas13d. The DNA-targeting effector protein may be a Type V Cas protein, such as Cas12a (Cpf1), Cas12b (C2c2), or Cas12c (C2c3). In certain example embodiments, the guide molecules of the CRISPR System can comprise one or more guide molecules of Table 1C.

TABLE 1C Index to Guide Molecules Target SEQ ID 0_Human_papillomavirus_type_175_isolate_SE87_g_1 40500 0_Human_papillomavirus_type_175_isolate_SE87_g_2 40501 0_Human_papillomavirus_type_175_isolate_SE87_g_3 40502 0_Human_papiliomavirus_type_175_isolate_SE87_g_4 40503 0_Human_papiliomavirus_type_175_isolate_SE87_g_5 40504 1_Human_papillomavirus_type_175_isolate_SE87_g_1 40505 1_Human_papillomavirus_type_175_isolate_SE87_g_2 40506 1_Human_papillomavirus_type_175_isolate_SE87_g_3 40507 1_Human_papillomavirus_type_175_isolate_SE87_g_4 40508 1_Human_papillomavirus_type_175_isolate_SE87_g_5 40509 2_Human_papillomavirus_type_175_isolate_SE87_g_1 40510 2_Human_papillomavirus_type_175_isolate_SE87_g_2 40511 2_Human_papillomavirus_type_175_isolate_SE87_g_3 40512 2_Human_papillomavirus_type_175_isolate_SE87_g_4 40513 2_Human_papillomavirus_type_175_isolate_SE87_g_5 40514 3_Human_papillomavirus_type_175_isolate_SE87_g_1 40515 3_Human_papillomavirus_type_175_isolate_SE87_g_2 40516 3_Human_papillomavirus_type_175_isolate_SE87_g_3 40517 3_Human_papillomavirus_type_175_isolate_SE87_g_4 40518 3_Human_papillomavirus_type_175_isolate_SE87_g_5 40519 4_Human_papillomavirus_type_175_isolate_SE87_g_1 40520 4_Human_papillomavirus_type_175_isolate_SE87_g_2 40521 4_Human_papillomavirus_type_175_isolate_SE87_g_3 40522 4_Human_papillomavirus_type_175_isolate_SE87_g_4 40523 4_Human_papillomavirus_type_175_isolate_SE87_g_5 40524 5_Human_papillomavirus_type_175_isolate_SE87_g_1 40525 5_Human_papillomavirus_type_175_isolate_SE87_g_2 40526 5_Human_papillomavirus_type_175_isolate_SE87_g_3 40527 5_Human_papillomavirus_type_175_isolate_SE87_g_4 40528 5_Human_papillomavirus_type_175_isolate_SE87_g_5 40529 6_Human_papillomavirus_type_175_isolate_SE87_g_1 40530 6_Human_papillomavirus_type_175_isolate_SE87_g_2 40531 6_Human_papillomavirus_type_175_isolate_SE87_g_3 40532 6_Human_papillomavirus_type_175_isolate_SE87_g_4 40533 6_Human_papillomavirus_type_175_isolate_SE87_g_5 40534 7_Human_papillomavirus_type_175_isolate_SE87_g_1 40535 7_Human_papillomavirus_type_175_isolate_SE87_g_2 40536 7_Human_papillomavirus_type_175_isolate_SE87_g_3 40537 7_Human_papillomavirus_type_175_isolate_SE87_g_4 40538 7_Human_papillomavirus_type_175_isolate_SE87_g_5 40539 8_Human_papillomavirus_type_175_isolate_SE87_g_1 40540 8_Human_papillomavirus_type_175_isolate_SE87_g_2 40541 8_Human_papillomavirus_type_175_isolate_SE87_g_3 40542 8_Human_papillomavirus_type_175_isolate_SE87_g_4 40543 8_Human_papillomavirus_type_175_isolate_SE87_g_5 40544 9_Human_papillomavirus_type_175_isolate_SE87_g_1 40545 9_Human_papillomavirus_type_175_isolate_SE87_g_2 40546 9_Human_papillomavirus_type_175_isolate_SE87_g_3 40547 9_Human_papillomavirus_type_175_isolate_SE87_g_4 40548 9_Human_papillomavirus_type_175_isolate_SE87_g_5 40549 10_Human_papillomavirus_type_175_isolate_SE87_g_1 40550 10_Human_papillomavirus_type_175_isolate_SE87_g_2 40551 10_Human_papillomavirus_type_175_isolate_SE87_g_3 40552 10_Human_papillomavirus_type_175_isolate_SE87_g_4 40553 10_Human_papillomavirus_type_175_isolate_SE87_g_5 40554 11_Human_papillomavirus_type_175_isolate_SE87_g_1 40555 11_Human_papillomavirus_type_175_isolate_SE87_g_2 40556 11_Human_papillomavirus_type_175_isolate_SE87_g_3 40557 11_Human_papillomavirus_type_175_isolate_SE87_g_4 40558 11_Human_papillomavirus_type_175_isolate_SE87_g_5 40559 12_Human_papillomavirus_type_175_isolate_SE87_g_1 40560 12_Human_papillomavirus_type_175_isolate_SE87_g_2 40561 12_Human_papillomavirus_type_175_isolate_SE87_g_3 40562 12_Human_papillomavirus_type_175_isolate_SE87_g_4 40563 12_Human_papillomavirus_type_175_isolate_SE87_g_5 40564 13_Human_papillomavirus_type_175_isolate_SE87_g_1 40565 13_Human_papillomavirus_type_175_isolate_SE87_g_2 40566 13_Human_papillomavirus_type_175_isolate_SE87_g_3 40567 13_Human_papillomavirus_type_175_isolate_SE87_g_4 40568 13_Human_papillomavirus_type_175_isolate_SE87_g_5 40569 14_Human_papillomavirus_type_163_isolate_KC3_g_1 40570 14_Human_papillomavirus_type_163_isolate_KC3_g_2 40571 14_Human_papillomavirus_type_163_isolate_KC3_g_3 40572 14_Human_papillomavirus_type_163_isolate_KC3_g_4 40573 14_Human_papillomavirus_type_163_isolate_KC3_g_5 40574 15_Human_papillomavirus_type_163_isolate_KC3_g_1 40575 15_Human_papillomavirus_type_163_isolate_KC3_g_2 40576 15_Human_papillomavirus_type_163_isolate_KC3_g_3 40577 15_Human_papillomavirus_type_163_isolate_KC3_g_4 40578 15_Human_papillomavirus_type_163_isolate_KC3_g_5 40579 16_Human_papillomavirus_type_163_isolate_KC3_g_1 40580 16_Human_papillomavirus_type_163_isolate_KC3_g_2 40581 16_Human_papillomavirus_type_163_isolate_KC3_g_3 40582 16_Human_papillomavirus_type_163_isolate_KC3_g_4 40583 16_Human_papillomavirus_type_163_isolate_KC3_g_5 40584 17_Human_papillomavirus_type_163_isolate_KC3_g_1 40585 17_Human_papillomavirus_type_163_isolate_KC3_g_2 40586 17_Human_papillomavirus_type_163_isolate_KC3_g_3 40587 17_Human_papillomavirus_type_163_isolate_KC3_g_4 40588 17_Human_papillomavirus_type_163_isolate_KC3_g_5 40589 18_Human_papillomavirus_type_163_isolate_KC3_g_1 40590 18_Human_papillomavirus_type_163_isolate_KC3_g_2 40591 18_Human_papillomavirus_type_163_isolate_KC3_g_3 40592 18_Human_papillomavirus_type_163_isolate_KC3_g_4 40593 18_Human_papillomavirus_type_163_isolate_KC3_g_5 40594 19_Human_papillomavirus_type_163_isolate_KC3_g_1 40595 19_Human_papillomavirus_type_163_isolate_KC3_g_2 40596 19_Human_papillomavirus_type_163_isolate_KC3_g_3 40597 19_Human_papillomavirus_type_163_isolate_KC3_g_4 40598 19_Human_papillomavirus_type_163_isolate_KC3_g_5 40599 20_Human_papillomavirus_type_163_isolate_KC3_g_1 40600 20_Human_papillomavirus_type_163_isolate_KC3_g_2 40601 20_Human_papillomavirus_type_163_isolate_KC3_g_3 40602 20_Human_papillomavirus_type_163_isolate_KC3_g_4 40603 20_Human_papillomavirus_type_163_isolate_KC3_g_5 40604 21_Human_papillomavirus_type_163_isolate_KC3_g_1 40605 21_Human_papillomavirus_type_163_isolate_KC3_g_2 40606 21_Human_papillomavirus_type_163_isolate_KC3_g_3 40607 21_Human_papillomavirus_type_163_isolate_KC3_g_4 40608 21_Human_papillomavirus_type_163_isolate_KC3_g_5 40609 22_Human_papillomavirus_type_163_isolate_KC3_g_1 40610 22_Human_papillomavirus_type_163_isolate_KC3_g_2 40611 22_Human_papillomavirus_type_163_isolate_KC3_g_3 40612 22_Human_papillomavirus_type_163_isolate_KC3_g_4 40613 22_Human_papillomavirus_type_163_isolate_KC3_g_5 40614 23_Human_papillomavirus_type_163_isolate_KC3_g_1 40615 23_Human_papillomavirus_type_163_isolate_KC3_g_2 40616 23_Human_papillomavirus_type_163_isolate_KC3_g_3 40617 23_Human_papillomavirus_type_163_isolate_KC3_g_4 40618 23_Human_papillomavirus_type_163_isolate_KC3_g_5 40619 24_Human_papillomavirus_type_163_isolate_KC3_g_1 40620 24_Human_papillomavirus_type_163_isolate_KC3_g_2 40621 24_Human_papillomavirus_type_163_isolate_KC3_g_3 40622 24_Human_papillomavirus_type_163_isolate_KC3_g_4 40623 24_Human_papillomavirus_type_163_isolate_KC3_g_5 40624 25_Human_papillomavirus_type_163_isolate_KC3_g_1 40625 25_Human_papillomavirus_type_163_isolate_KC3_g_2 40626 25_Human_papillomavirus_type_163_isolate_KC3_g_3 40627 25_Human_papillomavirus_type_163_isolate_KC3_g_4 40628 25_Human_papillomavirus_type_163_isolate_KC3_g_5 40629 26_Human_papillomavirus_type_163_isolate_KC3_g_1 40630 26_Human_papillomavirus_type_163_isolate_KC3_g_2 40631 26_Human_papillomavirus_type_163_isolate_KC3_g_3 40632 26_Human_papillomavirus_type_163_isolate_KC3_g_4 40633 26_Human_papillomavirus_type_163_isolate_KC3_g_5 40634 27_Human_papillomavirus_type_163_isolate_KC3_g_1 40635 27_Human_papillomavirus_type_163_isolate_KC3_g_2 40636 27_Human_papillomavirus_type_163_isolate_KC3_g_3 40637 27_Human_papillomavirus_type_163_isolate_KC3_g_4 40638 27_Human_papillomavirus_type_163_isolate_KC3_g_5 40639 28_Hepatitis_C_virus_genotype_7_g_1 40640 28_Hepatitis_C_virus_genotype_7_g_2 40641 28_Hepatitis_C_virus_genotype_7_g_3 40642 28_Hepatitis_C_virus_genotype_7_g_4 40643 28_Hepatitis_C_virus_genotype_7_g_5 40644 29_Hepatitis_C_virus_genotype_7_g_1 40645 29_Hepatitis_C_virus_genotype_7_g_2 40646 29_Hepatitis_C_virus_genotype_7_g_3 40647 29_Hepatitis_C_virus_genotype_7_g_4 40648 29_Hepatitis_C_virus_genotype_7_g_5 40649 30_Hepatitis_C_virus_genotype_7_g_1 40650 30_Hepatitis_C_virus_genotype_7_g_2 40651 30_Hepatitis_C_virus_genotype_7_g_3 40652 30_Hepatitis_C_virus_genotype_7_g_4 40653 31_Hepatitis_C_virus_genotype_7_g_1 40654 31_Hepatitis_C_virus_genotype_7_g_2 40655 31_Hepatitis_C_virus_genotype_7_g_3 40656 31_Hepatitis_C_virus_genotype_7_g_4 40657 31_Hepatitis_C_virus_genotype_7_g_5 40658 32_Hepatitis_C_virus_genotype_7_g_1 40659 32_Hepatitis_C_virus_genotype_7_g_2 40660 32_Hepatitis_C_virus_genotype_7_g_3 40661 32_Hepatitis_C_virus_genotype_7_g_4 40662 32_Hepatitis_C_virus_genotype_7_g_5 40663 33_Hepatitis_C_virus_genotype_7_g_1 40664 33_Hepatitis_C_virus_genotype_7_g_2 40665 33_Hepatitis_C_virus_genotype_7_g_3 40666 33_Hepatitis_C_virus_genotype_7_g_4 40667 33_Hepatitis_C_virus_genotype_7_g_5 40668 34_Hepatitis_C_virus_genotype_7_g_1 40669 34_Hepatitis_C_virus_genotype_7_g_2 40670 34_Hepatitis_C_virus_genotype_7_g_3 40671 35_Hepatitis_C_virus_genotype_7_g_1 40672 35_Hepatitis_C_virus_genotype_7_g_2 40673 36_Hepatitis_C_virus_genotype_7_g_1 40674 36_Hepatitis_C_virus_genotype_7_g_2 40675 36_Hepatitis_C_virus_genotype_7_g_3 40676 36_Hepatitis_C_virus_genotype_7_g_4 40677 36_Hepatitis_C_virus_genotype_7_g_5 40678 37_Hepatitis_C_virus_genotype_7_g_1 40679 37_Hepatitis_C_virus_genotype_7_g_2 40680 37_Hepatitis_C_virus_genotype_7_g_3 40681 37_Hepatitis_C_virus_genotype_7_g_4 40682 37_Hepatitis_C_virus_genotype_7_g_5 40683 38_Hepatitis_C_virus_genotype_7_g_1 40684 38_Hepatitis_C_virus_genotype_7_g_2 40685 38_Hepatitis_C_virus_genotype_7_g_3 40686 38_Hepatitis_C_virus_genotype_7_g_4 40687 38_Hepatitis_C_virus_genotype_7_g_5 40688 39_Hepatitis_C_virus_genotype_7_g_1 40689 39_Hepatitis_C_virus_genotype_7_g_2 40690 39_Hepatitis_C_virus_genotype_7_g_3 40691 39_Hepatitis_C_virus_genotype_7_g_4 40692 40_Hepatitis_C_virus_genotype_7_g_1 40693 40_Hepatitis_C_virus_genotype_7_g_2 40694 40_Hepatitis_C_virus_genotype_7_g_3 40695 40_Hepatitis_C_virus_genotype_7_g_4 40696 40_Hepatitis_C_virus_genotype_7_g_5 40697 41_Hepatitis_C_virus_genotype_7_g_1 40698 41_Hepatitis_C_virus_genotype_7_g_2 40699 41_Hepatitis_C_virus_genotype_7_g_3 40700 41_Hepatitis_C_virus_genotype_7_g_4 40701 41_Hepatitis_C_virus_genotype_7_g_5 40702 42_Hepatitis_C_virus_genotype_7_g_1 40703 42_Hepatitis_C_virus_genotype_7_g_2 40704 42_Hepatitis_C_virus_genotype_7_g_3 40705 42_Hepatitis_C_virus_genotype_7_g_4 40706 42_Hepatitis_C_virus_genotype_7_g_5 40707 43_Hepatitis_C_virus_genotype_7_g_1 40708 43_Hepatitis_C_virus_genotype_7_g_2 40709 43_Hepatitis_C_virus_genotype_7_g_3 40710 43_Hepatitis_C_virus_genotype_7_g_4 40711 44_Hepatitis_C_virus_genotype_7_g_1 40712 44_Hepatitis_C_virus_genotype_7_g_2 40713 44_Hepatitis_C_virus_genotype_7_g_3 40714 44_Hepatitis_C_virus_genotype_7_g_4 40715 44_Hepatitis_C_virus_genotype_7_g_5 40716 45_Hepatitis_C_virus_genotype_7_g_1 40717 45_Hepatitis_C_virus_genotype_7_g_2 40718 45_Hepatitis_C_virus_genotype_7_g_3 40719 45_Hepatitis_C_virus_genotype_7_g_4 40720 45_Hepatitis_C_virus_genotype_7_g_5 40721 46_Hepatitis_C_virus_genotype_7_g_1 40722 46_Hepatitis_C_virus_genotype_7_g_2 40723 46_Hepatitis_C_virus_genotype_7_g_3 40724 46_Hepatitis_C_virus_genotype_7_g_4 40725 46_Hepatitis_C_virus_genotype_7_g_5 40726 47_Hepatitis_C_virus_genotype_7_g_1 40727 47_Hepatitis_C_virus_genotype_7_g_2 40728 47_Hepatitis_C_virus_genotype_7_g_3 40729 47_Hepatitis_C_virus_genotype_7_g_4 40730 47_Hepatitis_C_virus_genotype_7_g_5 40731 48_Hepatitis_C_virus_genotype_7_g_1 40732 48_Hepatitis_C_virus_genotype_7_g_2 40733 48_Hepatitis_C_virus_genotype_7_g_3 40734 48_Hepatitis_C_virus_genotype_7_g_4 40735 48_Hepatitis_C_virus_genotype_7_g_5 40736 49_Hepatitis_C_virus_genotype_7_g_1 40737 49_Hepatitis_C_virus_genotype_7_g_2 40738 49_Hepatitis_C_virus_genotype_7_g_3 40739 49_Hepatitis_C_virus_genotype_7_g_4 40740 50_Hepatitis_C_virus_genotype_7_g_1 40741 50_Hepatitis_C_virus_genotype_7_g_2 40742 50_Hepatitis_C_virus_genotype_7_g_3 40743 50_Hepatitis_C_virus_genotype_7_g_4 40744 50_Hepatitis_C_virus_genotype_7_g_5 40745 51_Hepatitis_C_virus_genotype_7_g_1 40746 51_Hepatitis_C_virus_genotype_7_g_2 40747 51_Hepatitis_C_virus_genotype_7_g_3 40748 51_Hepatitis_C_virus_genotype_7_g_4 40749 51_Hepatitis_C_virus_genotype_7_g_5 40750 52_Hepatitis_C_virus_genotype_7_g_1 40751 52_Hepatitis_C_virus_genotype_7_g_2 40752 52_Hepatitis_C_virus_genotype_7_g_3 40753 52_Hepatitis_C_virus_genotype_7_g_4 40754 52_Hepatitis_C_virus_genotype_7_g_5 40755 53_Hepatitis_C_virus_genotype_7_g_1 40756 53_Hepatitis_C_virus_genotype_7_g_2 40757 53_Hepatitis_C_virus_genotype_7_g_3 40758 53_Hepatitis_C_virus_genotype_7_g_4 40759 53_Hepatitis_C_virus_genotype_7_g_5 40760 54_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_1 40761 54_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_2 40762 54_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_3 40763 54_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_4 40764 54_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_5 40765 55_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_1 40766 55_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_2 40767 55_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_3 40768 55_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_4 40769 55_Influenza_C_virus_(C/Ann_Arbor/1/50)_M1_g_5 40770 56_Influenza_B_virus_RNA_1_g_1 40771 56_Influenza_B_virus_RNA_1_g_2 40772 56_Influenza_B_virus_RNA_1_g_3 40773 56_Influenza_B_virus_RNA_1_g_4 40774 56_Influenza_B_virus_RNA_1_g_5 40775 57_Influenza_B_virus_RNA_1_g_1 40776 57_Influenza_B_virus_RNA_1_g_2 40777 57_Influenza_B_virus_RNA_1_g_3 40778 57_Influenza_B_virus_RNA_1_g_4 40779 57_Influenza_B_virus_RNA_1_g_5 40780 58_Influenza_B_virus_RNA_1_g_1 40781 58_Influenza_B_virus_RNA_1_g_2 40782 58_Influenza_B_virus_RNA_1_g_3 40783 58_Influenza_B_virus_RNA_1_g_4 40784 58_Influenza_B_virus_RNA_1_g_5 40785 59_Influenza_B_virus_RNA_1_g_1 40786 59_Influenza_B_virus_RNA_1_g_2 40787 59_Influenza_B_virus_RNA_1_g_3 40788 59_Influenza_B_virus_RNA_1_g_4 40789 59_Influenza_B_virus_RNA_1_g_5 40790 60_Influenza_B_virus_RNA_1_g_1 40791 60_Influenza_B_virus_RNA_1_g_2 40792 60_Influenza_B_virus_RNA_1_g_3 40793 60_Influenza_B_virus_RNA_1_g_4 40794 60_Influenza_B_virus_RNA_1_g_5 40795 61_Influenza_B_virus_RNA_1_g_1 40796 61_Influenza_B_virus_RNA_1_g_2 40797 61_Influenza_B_virus_RNA_1_g_3 40798 61_Influenza_B_virus_RNA_1_g_4 40799 61_Influenza_B_virus_RNA_1_g_5 40800 62_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_1 40801 62_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_2 40802 62_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_3 40803 62_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_4 40804 62_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_5 40805 63_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_1 40806 63_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_2 40807 63_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_3 40808 63_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_4 40809 63_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_5 40810 64_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_1 40811 64_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_2 40812 64_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_3 40813 64_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_4 40814 64_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_5 40815 65_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_1 40816 65_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_2 40817 65_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_3 40818 65_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_4 40819 65_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_5 40820 66_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_1 40821 66_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_2 40822 66_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_3 40823 66_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_4 40824 66_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_4_g_5 40825 67_Respiratory_syncytial_virus_g_1 40826 67_Respiratory_syncytial_virus_g_2 40827 67_Respiratory_syncytial_virus_g_3 40828 67_Respiratory_syncytial_virus_g_4 40829 67_Respiratory_syncytial_virus_g_5 40830 68_Respiratory_syncytial_virus_g_1 40831 68_Respiratory_syncytial_virus_g_2 40832 68_Respiratory_syncytial_virus_g_3 40833 68_Respiratory_syncytial_virus_g_4 40834 68_Respiratory_syncytial_virus_g_5 40835 69_Respiratory_syncytial_virus_g_1 40836 69_Respiratory_syncytial_virus_g_2 40837 69_Respiratory_syncytial_virus_g_3 40838 69_Respiratory_syncytial_virus_g_4 40839 69_Respiratory_syncytial_virus_g_5 40840 70_Respiratory_syncytial_virus_g_1 40841 70_Respiratory_syncytial_virus_g_2 40842 70_Respiratory_syncytial_virus_g_3 40843 70_Respiratory_syncytial_virus_g_4 40844 70_Respiratory_syncytial_virus_g_5 40845 71_Respiratory_syncytial_virus_g_1 40846 71_Respiratory_syncytial_virus_g_2 40847 71_Respiratory_syncytial_virus_g_3 40848 71_Respiratory_syncytial_virus_g_4 40849 71_Respiratory_syncytial_virus_g_5 40850 72_Respiratory_syncytial_virus_g_1 40851 72_Respiratory_syncytial_virus_g_2 40852 72_Respiratory_syncytial_virus_g_3 40853 72_Respiratory_syncytial_virus_g_4 40854 72_Respiratory_syncytial_virus_g_5 40855 73_Respiratory_syncytial_virus_g_1 40856 73_Respiratory_syncytial_virus_g_2 40857 73_Respiratory_syncytial_virus_g_3 40858 73_Respiratory_syncytial_virus_g_4 40859 73_Respiratory_syncytial_virus_g_5 40860 74_Respiratory_syncytial_virus_g_1 40861 74_Respiratory_syncytial_virus_g_2 40862 74_Respiratory_syncytial_virus_g_3 40863 74_Respiratory_syncytial_virus_g_4 40864 74_Respiratory_syncytial_virus_g_5 40865 75_Respiratory_syncytial_virus_g_1 40866 75_Respiratory_syncytial_virus_g_2 40867 75_Respiratory_syncytial_virus_g_3 40868 75_Respiratory_syncytial_virus_g_4 40869 75_Respiratory_syncytial_virus_g_5 40870 76_Respiratory_syncytial_virus_g_1 40871 76_Respiratory_syncytial_virus_g_2 40872 76_Respiratory_syncytial_virus_g_3 40873 76_Respiratory_syncytial_virus_g_4 40874 76_Respiratory_syncytial_virus_g_5 40875 77_Respiratory_syncytial_virus_g_1 40876 77_Respiratory_syncytial_virus_g_2 40877 77_Respiratory_syncytial_virus_g_3 40878 77_Respiratory_syncytial_virus_g_4 40879 77_Respiratory_syncytial_virus_g_5 40880 78_Respiratory_syncytial_virus_g_1 40881 78_Respiratory_syncytial_virus_g_2 40882 78_Respiratory_syncytial_virus_g_3 40883 78_Respiratory_syncytial_virus_g_4 40884 78_Respiratory_syncytial_virus_g_5 40885 79_Respiratory_syncytial_virus_g_1 40886 79_Respiratory_syncytial_virus_g_2 40887 79_Respiratory_syncytial_virus_g_3 40888 79_Respiratory_syncytial_virus_g_4 40889 79_Respiratory_syncytial_virus_g_5 40890 80_Respiratory_syncytial_virus_g_1 40891 80_Respiratory_syncytial_virus_g_2 40892 80_Respiratory_syncytial_virus_g_3 40893 80_Respiratory_syncytial_virus_g_4 40894 80_Respiratory_syncytial_virus_g_5 40895 81_Respiratory_syncytial_virus_g_1 40896 81_Respiratory_syncytial_virus_g_2 40897 81_Respiratory_syncytial_virus_g_3 40898 81_Respiratory_syncytial_virus_g_4 40899 81_Respiratory_syncytial_virus_g_5 40900 82_Respiratory_syncytial_virus_g_1 40901 82_Respiratory_syncytial_virus_g_2 40902 82_Respiratory_syncytial_virus_g_3 40903 82_Respiratory_syncytial_virus_g_4 40904 82_Respiratory_syncytial_virus_g_5 40905 83_Respiratory_syncytial_virus_g_1 40906 83_Respiratory_syncytial_virus_g_2 40907 83_Respiratory_syncytial_virus_g_3 40908 83_Respiratory_syncytial_virus_g_4 40909 83_Respiratory_syncytial_virus_g_5 40910 84_Respiratory_syncytial_virus_g_1 40911 84_Respiratory_syncytial_virus_g_2 40912 84_Respiratory_syncytial_virus_g_3 40913 84_Respiratory_syncytial_virus_g_4 40914 84_Respiratory_syncytial_virus_g_5 40915 85_Respiratory_syncytial_virus_g_1 40916 85_Respiratory_syncytial_virus_g_2 40917 85_Respiratory_syncytial_virus_g_3 40918 85_Respiratory_syncytial_virus_g_4 40919 85_Respiratory_syncytial_virus_g_5 40920 86_Respiratory_syncytial_virus_g_1 40921 86_Respiratory_syncytial_virus_g_2 40922 86_Respiratory_syncytial_virus_g_3 40923 86_Respiratory_syncytial_virus_g_4 40924 86_Respiratory_syncytial_virus_g_5 40925 87_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40926 87_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40927 87_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40928 87_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40929 88_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40930 88_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40931 88_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40932 88_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40933 88_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40934 89_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40935 89_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40936 89_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40937 89_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40938 89_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40939 90_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40940 90_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40941 90_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40942 90_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40943 90_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40944 91_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40945 91_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40946 92_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40947 92_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40948 92_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40949 92_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40950 92_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40951 93_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40952 93_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40953 93_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40954 93_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40955 93_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40956 94_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40957 94_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40958 94_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40959 95_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40960 95_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40961 95_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40962 95_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40963 95_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40964 96_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40965 96_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40966 96_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40967 96_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40968 96_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40969 97_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40970 97_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40971 97_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40972 97_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40973 98_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40974 98_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40975 98_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40976 98_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40977 99_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40978 99_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40979 99_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40980 99_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40981 99_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40982 100_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40983 100_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40984 100_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40985 100_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40986 100_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40987 101_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40988 101_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40989 101_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40990 101_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40991 101_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 40992 102_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40993 102_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40994 102_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40995 103_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 40996 103_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 40997 103_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 40998 103_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 40999 103_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41000 104_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41001 104_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41002 104_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41003 104_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41004 104_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41005 105_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41006 105_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41007 106_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41008 106_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41009 106_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41010 107_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41011 107_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41012 107_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41013 107_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41014 107_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41015 108_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41016 108_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41017 108_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41018 108_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41019 108_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41020 109_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41021 109_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41022 109_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41023 109_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41024 109_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41025 110_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41026 110_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41027 110_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41028 110_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41029 110_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41030 111_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41031 111_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41032 111_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41033 111_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41034 111_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41035 112_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41036 112_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41037 112_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41038 112_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41039 112_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41040 113_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41041 113_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41042 113_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41043 113_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41044 113_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41045 114_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41046 114_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41047 114_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41048 114_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41049 114_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41050 115_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_1 41051 115_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_2 41052 115_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_3 41053 115_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_4 41054 115_Hepatitis_C_virus_(isolate_H77)_genotype_1_g_5 41055 116_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41056 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 116_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41057 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 116_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41058 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 116_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41059 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 116_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41060 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 117_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41061 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 117_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41062 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 117_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41063 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 117_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41064 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 117_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41065 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 118_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41066 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 118_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41067 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 118_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41068 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 118_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41069 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 118_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41070 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 119_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41071 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 119_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41072 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 119_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41073 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 119_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41074 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 119_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41075 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 120_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41076 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 120_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41077 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 120_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41078 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 120_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41079 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 120_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41080 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 121_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41081 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 121_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41082 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 121_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41083 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 121_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41084 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 121_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 41085 polymerase_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 122_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_1 41086 122_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_2 41087 122_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_3 41088 122_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_4 41089 122_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_5 41090 123_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_1 41091 123_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_2 41092 123_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_3 41093 123_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_4 41094 123_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_8_g_5 41095 124_Human_papillomavirus_54_g_1 41096 124_Human_papillomavirus_54_g_2 41097 124_Human_papillomavirus_54_g_3 41098 124_Human_papillomavirus_54_g_4 41099 124_Human_papillomavirus_54_g_5 41100 125_Human_papillomavirus_54_g_1 41101 125_Human_papillomavirus_54_g_2 41102 125_Human_papillomavirus_54_g_3 41103 125_Human_papillomavirus_54_g_4 41104 125_Human_papillomavirus_54_g_5 41105 126_Human_papillomavirus_54_g_1 41106 126_Human_papillomavirus_54_g_2 41107 126_Human_papillomavirus_54_g_3 41108 126_Human_papillomavirus_54_g_4 41109 126_Human_papillomavirus_54_g_5 41110 127_Human_papillomavirus_54_g_1 41111 127_Human_papillomavirus_54_g_2 41112 127_Human_papillomavirus_54_g_3 41113 127_Human_papillomavirus_54_g_4 41114 127_Human_papillomavirus_54_g_5 41115 128_Human_papillomavirus_54_g_1 41116 128_Human_papillomavirus_54_g_2 41117 128_Human_papillomavirus_54_g_3 41118 128_Human_papillomavirus_54_g_4 41119 128_Human_papillomavirus_54_g_5 41120 129_Human_papillomavirus_54_g_1 41121 129_Human_papillomavirus_54_g_2 41122 129_Human_papillomavirus_54_g_3 41123 129_Human_papillomavirus_54_g_4 41124 129_Human_papillomavirus_54_g_5 41125 130_Human_papillomavirus_54_g_1 41126 130_Human_papillomavirus_54_g_2 41127 130_Human_papillomavirus_54_g_3 41128 130_Human_papillomavirus_54_g_4 41129 130_Human_papillomavirus_54_g_5 41130 131_Human_papillomavirus_54_g_1 41131 131_Human_papillomavirus_54_g_2 41132 131_Human_papillomavirus_54_g_3 41133 131_Human_papillomavirus_54_g_4 41134 131_Human_papillomavirus_54_g_5 41135 132_Human_papillomavirus_54_g_1 41136 132_Human_papillomavirus_54_g_2 41137 132_Human_papillomavirus_54_g_3 41138 132_Human_papillomavirus_54_g_4 41139 132_Human_papillomavirus_54_g_5 41140 133_Human_papillomavirus_54_g_1 41141 133_Human_papillomavirus_54_g_2 41142 133_Human_papillomavirus_54_g_3 41143 133_Human_papillomavirus_54_g_4 41144 133_Human_papillomavirus_54_g_5 41145 134_Human_papillomavirus_54_g_1 41146 134_Human_papillomavirus_54_g_2 41147 134_Human_papillomavirus_54_g_3 41148 134_Human_papillomavirus_54_g_4 41149 134_Human_papillomavirus_54_g_5 41150 135_Human_papillomavirus_54_g_1 41151 135_Human_papillomavirus_54_g_2 41152 135_Human_papillomavirus_54_g_3 41153 135_Human_papillomavirus_54_g_4 41154 135_Human_papillomavirus_54_g_5 41155 136_Human_papillomavirus_54_g_1 41156 136_Human_papillomavirus_54_g_2 41157 136_Human_papillomavirus_54_g_3 41158 136_Human_papillomavirus_54_g_4 41159 136_Human_papillomavirus_54_g_5 41160 137_Human_T-lymphotropic_virus_1_g_1 41161 137_Human_T-lymphotropic_virus_1_g_2 41162 137_Human_T-lymphotropic_virus_1_g_3 41163 137_Human_T-lymphotropic_virus_1_g_4 41164 137_Human_T-lymphotropic_virus_1_g_5 41165 138_Human_T-lymphotropic_virus_1_g_1 41166 138_Human_T-lymphotropic_virus_1_g_2 41167 138_Human_T-lymphotropic_virus_1_g_3 41168 138_Human_T-lymphotropic_virus_1_g_4 41169 138_Human_T-lymphotropic_virus_1_g_5 41170 139_Human_T-lymphotropic_virus_1_g_1 41171 139_Human_T-lymphotropic_virus_1_g_2 41172 139_Human_T-lymphotropic_virus_1_g_3 41173 139_Human_T-lymphotropic_virus_1_g_4 41174 139_Human_T-lymphotropic_virus_1_g_5 41175 140_Human_T-lymphotropic_virus_1_g_1 41176 140_Human_T-lymphotropic_virus_1_g_2 41177 140_Human_T-lymphotropic_virus_1_g_3 41178 140_Human_T-lymphotropic_virus_1_g_4 41179 140_Human_T-lymphotropic_virus_1_g_5 41180 141_Human_T-lymphotropic_virus_1_g_1 41181 141_Human_T-lymphotropic_virus_1_g_2 41182 141_Human_T-lymphotropic_virus_1_g_3 41183 141_Human_T-lymphotropic_virus_1_g_4 41184 141_Human_T-lymphotropic_virus_1_g_5 41185 142_Human_T-lymphotropic_virus_1_g_1 41186 142_Human_T-lymphotropic_virus_1_g_2 41187 142_Human_T-lymphotropic_virus_1_g_3 41188 142_Human_T-lymphotropic_virus_1_g_4 41189 142_Human_T-lymphotropic_virus_1_g_5 41190 143_Human_T-lymphotropic_virus_1_g_1 41191 143_Human_T-lymphotropic_virus_1_g_2 41192 143_Human_T-lymphotropic_virus_1_g_3 41193 143_Human_T-lymphotropic_virus_1_g_4 41194 143_Human_T-lymphotropic_virus_1_g_5 41195 144_Human_T-lymphotropic_virus_1_g_1 41196 144_Human_T-lymphotropic_virus_1_g_2 41197 144_Human_T-lymphotropic_virus_1_g_3 41198 144_Human_T-lymphotropic_virus_1_g_4 41199 144_Human_T-lymphotropic_virus_1_g_5 41200 145_Human_T-lymphotropic_virus_1_g_1 41201 145_Human_T-lymphotropic_virus_1_g_2 41202 145_Human_T-lymphotropic_virus_1_g_3 41203 145_Human_T-lymphotropic_virus_1_g_4 41204 145_Human_T-lymphotropic_virus_1_g_5 41205 146_Human_T-lymphotropic_virus_1_g_1 41206 146_Human_T-lymphotropic_virus_1_g_2 41207 146_Human_T-lymphotropic_virus_1_g_3 41208 146_Human_T-lymphotropic_virus_1_g_4 41209 146_Human_T-lymphotropic_virus_1_g_5 41210 147_Human_T-lymphotropic_virus_1_g_1 41211 147_Human_T-lymphotropic_virus_1_g_2 41212 147_Human_T-lymphotropic_virus_1_g_3 41213 147_Human_T-lymphotropic_virus_1_g_4 41214 147_Human_T-lymphotropic_virus_1_g_5 41215 148_Human_T-lymphotropic_virus_1_g_1 41216 148_Human_T-lymphotropic_virus_1_g_2 41217 148_Human_T-lymphotropic_virus_1_g_3 41218 148_Human_T-lymphotropic_virus_1_g_4 41219 148_Human_T-lymphotropic_virus_1_g_5 41220 149_Human_T-lymphotropic_virus_1_g_1 41221 149_Human_T-lymphotropic_virus_1_g_2 41222 149_Human_T-lymphotropic_virus_1_g_3 41223 149_Human_T-lymphotropic_virus_1_g_4 41224 149_Human_T-lymphotropic_virus_1_g_5 41225 150_Human_T-lymphotropic_virus_1_g_1 41226 150_Human_T-lymphotropic_virus_1_g_2 41227 150_Human_T-lymphotropic_virus_1_g_3 41228 150_Human_T-lymphotropic_virus_1_g_4 41229 151_Human_T-lymphotropic_virus_1_g_1 41230 151_Human_T-lymphotropic_virus_1_g_2 41231 151_Human_T-lymphotropic_virus_1_g_3 41232 151_Human_T-lymphotropic_virus_1_g_4 41233 151_Human_T-lymphotropic_virus_1_g_5 41234 152_Human_T-lymphotropic_virus_1_g_1 41235 152_Human_T-lymphotropic_virus_1_g_2 41236 152_Human_T-lymphotropic_virus_1_g_3 41237 152_Human_T-lymphotropic_virus_1_g_4 41238 152_Human_T-lymphotropic_virus_1_g_5 41239 153_Human_T-lymphotropic_virus_1_g_1 41240 153_Human_T-lymphotropic_virus_1_g_2 41241 153_Human_T-lymphotropic_virus_1_g_3 41242 153_Human_T-lymphotropic_virus_1_g_4 41243 153_Human_T-lymphotropic_virus_1_g_5 41244 154_Human_T-lymphotropic_virus_1_g_1 41245 154_Human_T-lymphotropic_virus_1_g_2 41246 154_Human_T-lymphotropic_virus_1_g_3 41247 154_Human_T-lymphotropic_virus_1_g_4 41248 154_Human_T-lymphotropic_virus_1_g_5 41249 155_Human_T-lymphotropic_virus_1_g_1 41250 155_Human_T-lymphotropic_virus_1_g_2 41251 155_Human_T-lymphotropic_virus_1_g_3 41252 155_Human_T-lymphotropic_virus_1_g_4 41253 155_Human_T-lymphotropic_virus_1_g_5 41254 156_Human_T-lymphotropic_virus_1_g_1 41255 156_Human_T-lymphotropic_virus_1_g_2 41256 156_Human_T-lymphotropic_virus_1_g_3 41257 156_Human_T-lymphotropic_virus_1_g_4 41258 156_Human_T-lymphotropic_virus_1_g_5 41259 157_Human_T-lymphotropic_virus_1_g_1 41260 157_Human_T-lymphotropic_virus_1_g_2 41261 157_Human_T-lymphotropic_virus_1_g_3 41262 157_Human_T-lymphotropic_virus_1_g_4 41263 157_Human_T-lymphotropic_virus_1_g_5 41264 158_Human_T-lymphotropic_virus_1_g_1 41265 158_Human_T-lymphotropic_virus_1_g_2 41266 158_Human_T-lymphotropic_virus_1_g_3 41267 158_Human_T-lymphotropic_virus_1_g_4 41268 158_Human_T-lymphotropic_virus_1_g_5 41269 159_Human_T-lymphotropic_virus_1_g_1 41270 159_Human_T-lymphotropic_virus_1_g_2 41271 159_Human_T-lymphotropic_virus_1_g_3 41272 159_Human_T-lymphotropic_virus_1_g_4 41273 159_Human_T-lymphotropic_virus_1_g_5 41274 160_Human_T-lymphotropic_virus_1_g_1 41275 160_Human_T-lymphotropic_virus_1_g_2 41276 160_Human_T-lymphotropic_virus_1_g_3 41277 160_Human_T-lymphotropic_virus_1_g_4 41278 160_Human_T-lymphotropic_virus_1_g_5 41279 161_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_1 41280 161_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_2 41281 161_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_3 41282 161_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_4 41283 161_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_5 41284 162_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_1 41285 162_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_2 41286 162_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_3 41287 162_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_4 41288 162_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_5 41289 163_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_1 41290 163_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_2 41291 163_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_3 41292 163_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_4 41293 163_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_5 41294 164_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_1 41295 164_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_2 41296 164_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_3 41297 164_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_4 41298 165_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_1 41299 165_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_2 41300 165_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_3 41301 165_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_4 41302 165_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_5 41303 166_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_1 41304 166_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_2 41305 166_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_3 41306 166_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_4 41307 166_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_5 41308 167_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_1 41309 167_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_2 41310 167_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_3 41311 167_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_4 41312 167_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_5 41313 168_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_1 41314 168_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_2 41315 168_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_3 41316 168_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_4 41317 168_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_5 41318 169_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_1 41319 169_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_2 41320 169_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_3 41321 169_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_4 41322 169_Influenza_A_virus_(A/Korea/426/1968(H2N2))_segment_1_g_5 41323 170_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_1 41324 170_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_2 41325 170_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_3 41326 170_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_4 41327 170_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_5 41328 171_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_1 41329 171_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_2 41330 171_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_3 41331 171_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_4 41332 171_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_8_g_5 41333 172_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41334 segment_2_polymerase_PB1_(PB1)_gene_g_1 172_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41335 segment_2_polymerase_PB1_(PB1)_gene_g_2 172_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41336 segment_2_polymerase_PB1_(PB1)_gene_g_3 172_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41337 segment_2_polymerase_PB1_(PB1)_gene_g_4 172_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41338 segment_2_polymerase_PB1_(PB1)_gene_g_5 173_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41339 segment_2_polymerase_PB1_(PB1)_gene_g_1 173_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41340 segment_2_polymerase_PB1_(PB1)_gene_g_2 173_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41341 segment_2_polymerase_PB1_(PB1)_gene_g_3 173_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41342 segment_2_polymerase_PB1_(PB1)_gene_g_4 173_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41343 segment_2_polymerase_PB1_(PB1)_gene_g_5 174_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41344 segment_2_polymerase_PB1_(PB1)_gene_g_1 174_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41345 segment_2_polymerase_PB1_(PB1)_gene_g_2 174_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41346 segment_2_polymerase_PB1_(PB1)_gene_g_3 174_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41347 segment_2_polymerase_PB1_(PB1)_gene_g_4 174_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41348 segment_2_polymerase_PB1_(PB1)_gene_g_5 175_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41349 segment_2_polymerase_PB1_(PB1)_gene_g_1 175_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41350 segment_2_polymerase_PB1_(PB1)_gene_g_2 175_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41351 segment_2_polymerase_PB1_(PB1)_gene_g_3 175_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41352 segment_2_polymerase_PB1_(PB1)_gene_g_4 175_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41353 segment_2_polymerase_PB1_(PB1)_gene_g_5 176_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41354 segment_2_polymerase_PB1_(PB1)_gene_g_1 176_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41355 segment_2_polymerase_PB1_(PB1)_gene_g_2 176_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41356 segment_2_polymerase_PB1_(PB1)_gene_g_3 176_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41357 segment_2_polymerase_PB1_(PB1)_gene_g_4 176_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41358 segment_2_polymerase_PB1_(PB1)_gene_g_5 177_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41359 segment_2_polymerase_PB1_(PB1)_gene_g_1 177_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41360 segment_2_polymerase_PB1_(PB1)_gene_g_2 177_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41361 segment_2_polymerase_PB1_(PB1)_gene_g_3 177_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41362 segment_2_polymerase_PB1_(PB1)_gene_g_4 177_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41363 segment_2_polymerase_PB1_(PB1)_gene_g_5 178_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41364 segment_2_polymerase_PB1_(PB1)_gene_g_1 178_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41365 segment_2_polymerase_PB1_(PB1)_gene_g_2 178_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41366 segment_2_polymerase_PB1_(PB1)_gene_g_3 178_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41367 segment_2_polymerase_PB1_(PB1)_gene_g_4 178_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 41368 segment_2_polymerase_PB1_(PB1)_gene_g_5 179_Human_herpesvirus_5_strain_Merlin_g_1 41369 179_Human_herpesvirus_5_strain_Merlin_g_2 41370 179_Human_herpesvirus_5_strain_Merlin_g_3 41371 179_Human_herpesvirus_5_strain_Merlin_g_4 41372 179_Human_herpesvirus_5_strain_Merlin_g_5 41373 180_Human_herpesvirus_5_strain_Merlin_g_1 41374 180_Human_herpesvirus_5_strain_Merlin_g_2 41375 180_Human_herpesvirus_5_strain_Merlin_g_3 41376 180_Human_herpesvirus_5_strain_Merlin_g_4 41377 180_Human_herpesvirus_5_strain_Merlin_g_5 41378 181_Human_herpesvirus_5_strain_Merlin_g_1 41379 181_Human_herpesvirus_5_strain_Merlin_g_2 41380 181_Human_herpesvirus_5_strain_Merlin_g_3 41381 181_Human_herpesvirus_5_strain_Merlin_g_4 41382 181_Human_herpesvirus_5_strain_Merlin_g_5 41383 182_Human_herpesvirus_5_strain_Merlin_g_1 41384 182_Human_herpesvirus_5_strain_Merlin_g_2 41385 182_Human_herpesvirus_5_strain_Merlin_g_3 41386 182_Human_herpesvirus_5_strain_Merlin_g_4 41387 182_Human_herpesvirus_5_strain_Merlin_g_5 41388 184_Human_herpesvirus_5_strain_Merlin_g_1 41389 184_Human_herpesvirus_5_strain_Merlin_g_2 41390 184_Human_herpesvirus_5_strain_Merlin_g_3 41391 184_Human_herpesvirus_5_strain_Merlin_g_4 41392 184_Human_herpesvirus_5_strain_Merlin_g_5 41393 185_Human_herpesvirus_5_strain_Merlin_g_1 41394 185_Human_herpesvirus_5_strain_Merlin_g_2 41395 185_Human_herpesvirus_5_strain_Merlin_g_3 41396 186_Human_herpesvirus_5_strain_Merlin_g_1 41397 186_Human_herpesvirus_5_strain_Merlin_g_2 41398 186_Human_herpesvirus_5_strain_Merlin_g_3 41399 186_Human_herpesvirus_5_strain_Merlin_g_4 41400 186_Human_herpesvirus_5_strain_Merlin_g_5 41401 187_Human_herpesvirus_5_strain_Merlin_g_1 41402 187_Human_herpesvirus_5_strain_Merlin_g_2 41403 187_Human_herpesvirus_5_strain_Merlin_g_3 41404 187_Human_herpesvirus_5_strain_Merlin_g_4 41405 187_Human_herpesvirus_5_strain_Merlin_g_5 41406 188_Human_herpesvirus_5_strain_Merlin_g_1 41407 188_Human_herpesvirus_5_strain_Merlin_g_2 41408 188_Human_herpesvirus_5_strain_Merlin_g_3 41409 188_Human_herpesvirus_5_strain_Merlin_g_4 41410 188_Human_herpesvirus_5_strain_Merlin_g_5 41411 189_Human_herpesvirus_5_strain_Merlin_g_1 41412 189_Human_herpesvirus_5_strain_Merlin_g_2 41413 189_Human_herpesvirus_5_strain_Merlin_g_3 41414 189_Human_herpesvirus_5_strain_Merlin_g_4 41415 189_Human_herpesvirus_5_strain_Merlin_g_5 41416 190_Human_herpesvirus_5_strain_Merlin_g_1 41417 190_Human_herpesvirus_5_strain_Merlin_g_2 41418 190_Human_herpesvirus_5_strain_Merlin_g_3 41419 191_Human_herpesvirus_5_strain_Merlin_g_1 41420 191_Human_herpesvirus_5_strain_Merlin_g_2 41421 191_Human_herpesvirus_5_strain_Merlin_g_3 41422 191_Human_herpesvirus_5_strain_Merlin_g_4 41423 191_Human_herpesvirus_5_strain_Merlin_g_5 41424 192_Human_herpesvirus_5_strain_Merlin_g_1 41425 192_Human_herpesvirus_5_strain_Merlin_g_2 41426 192_Human_herpesvirus_5_strain_Merlin_g_3 41427 193_Human_herpesvirus_5_strain_Merlin_g_1 41428 193_Human_herpesvirus_5_strain_Merlin_g_2 41429 193_Human_herpesvirus_5_strain_Merlin_g_3 41430 193_Human_herpesvirus_5_strain_Merlin_g_4 41431 193_Human_herpesvirus_5_strain_Merlin_g_5 41432 194_Human_herpesvirus_5_strain_Merlin_g_1 41433 194_Human_herpesvirus_5_strain_Merlin_g_2 41434 194_Human_herpesvirus_5_strain_Merlin_g_3 41435 194_Human_herpesvirus_5_strain_Merlin_g_4 41436 194_Human_herpesvirus_5_strain_Merlin_g_5 41437 195_Human_herpesvirus_5_strain_Merlin_g_1 41438 195_Human_herpesvirus_5_strain_Merlin_g_2 41439 195_Human_herpesvirus_5_strain_Merlin_g_3 41440 195_Human_herpesvirus_5_strain_Merlin_g_4 41441 195_Human_herpesvirus_5_strain_Merlin_g_5 41442 196_Human_herpesvirus_5_strain_Merlin_g_1 41443 196_Human_herpesvirus_5_strain_Merlin_g_2 41444 196_Human_herpesvirus_5_strain_Merlin_g_3 41445 196_Human_herpesvirus_5_strain_Merlin_g_4 41446 196_Human_herpesvirus_5_strain_Merlin_g_5 41447 197_Human_herpesvirus_5_strain_Merlin_g_1 41448 197_Human_herpesvirus_5_strain_Merlin_g_2 41449 197_Human_herpesvirus_5_strain_Merlin_g_3 41450 197_Human_herpesvirus_5_strain_Merlin_g_4 41451 197_Human_herpesvirus_5_strain_Merlin_g_5 41452 198_Human_herpesvirus_5_strain_Merlin_g_1 41453 198_Human_herpesvirus_5_strain_Merlin_g_2 41454 198_Human_herpesvirus_5_strain_Merlin_g_3 41455 198_Human_herpesvirus_5_strain_Merlin_g_4 41456 198_Human_herpesvirus_5_strain_Merlin_g_5 41457 199_Human_herpesvirus_5_strain_Merlin_g_1 41458 199_Human_herpesvirus_5_strain_Merlin_g_2 41459 199_Human_herpesvirus_5_strain_Merlin_g_3 41460 200_Human_herpesvirus_5_strain_Merlin_g_1 41461 200_Human_herpesvirus_5_strain_Merlin_g_2 41462 200_Human_herpesvirus_5_strain_Merlin_g_3 41463 200_Human_herpesvirus_5_strain_Merlin_g_4 41464 200_Human_herpesvirus_5_strain_Merlin_g_5 41465 201_Human_herpesvirus_5_strain_Merlin_g_1 41466 201_Human_herpesvirus_5_strain_Merlin_g_2 41467 201_Human_herpesvirus_5_strain_Merlin_g_3 41468 201_Human_herpesvirus_5_strain_Merlin_g_4 41469 201_Human_herpesvirus_5_strain_Merlin_g_5 41470 202_Human_herpesvirus_5_strain_Merlin_g_1 41471 202_Human_herpesvirus_5_strain_Merlin_g_2 41472 202_Human_herpesvirus_5_strain_Merlin_g_3 41473 202_Human_herpesvirus_5_strain_Merlin_g_4 41474 202_Human_herpesvirus_5_strain_Merlin_g_5 41475 203_Human_herpesvirus_5_strain_Merlin_g_1 41476 203_Human_herpesvirus_5_strain_Merlin_g_2 41477 203_Human_herpesvirus_5_strain_Merlin_g_3 41478 203_Human_herpesvirus_5_strain_Merlin_g_4 41479 204_Human_herpesvirus_5_strain_Merlin_g_1 41480 204_Human_herpesvirus_5_strain_Merlin_g_2 41481 204_Human_herpesvirus_5_strain_Merlin_g_3 41482 204_Human_herpesvirus_5_strain_Merlin_g_4 41483 204_Human_herpesvirus_5_strain_Merlin_g_5 41484 205_Human_herpesvirus_5_strain_Merlin_g_1 41485 205_Human_herpesvirus_5_strain_Merlin_g_2 41486 205_Human_herpesvirus_5_strain_Merlin_g_3 41487 205_Human_herpesvirus_5_strain_Merlin_g_4 41488 205_Human_herpesvirus_5_strain_Merlin_g_5 41489 206_Human_herpesvirus_5_strain_Merlin_g_1 41490 206_Human_herpesvirus_5_strain_Merlin_g_2 41491 206_Human_herpesvirus_5_strain_Merlin_g_3 41492 206_Human_herpesvirus_5_strain_Merlin_g_4 41493 206_Human_herpesvirus_5_strain_Merlin_g_5 41494 207_Human_herpesvirus_5_strain_Merlin_g_1 41495 208_Human_herpesvirus_5_strain_Merlin_g_1 41496 208_Human_herpesvirus_5_strain_Merlin_g_2 41497 208_Human_herpesvirus_5_strain_Merlin_g_3 41498 208_Human_herpesvirus_5_strain_Merlin_g_4 41499 208_Human_herpesvirus_5_strain_Merlin_g_5 41500 209_Human_herpesvirus_5_strain_Merlin_g_1 41501 209_Human_herpesvirus_5_strain_Merlin_g_2 41502 209_Human_herpesvirus_5_strain_Merlin_g_3 41503 209_Human_herpesvirus_5_strain_Merlin_g_4 41504 209_Human_herpesvirus_5_strain_Merlin_g_5 41505 210_Human_herpesvirus_5_strain_Merlin_g_1 41506 210_Human_herpesvirus_5_strain_Merlin_g_2 41507 210_Human_herpesvirus_5_strain_Merlin_g_3 41508 210_Human_herpesvirus_5_strain_Merlin_g_4 41509 210_Human_herpesvirus_5_strain_Merlin_g_5 41510 211_Human_herpesvirus_5_strain_Merlin_g_1 41511 211_Human_herpesvirus_5_strain_Merlin_g_2 41512 211_Human_herpesvirus_5_strain_Merlin_g_3 41513 211_Human_herpesvirus_5_strain_Merlin_g_4 41514 211_Human_herpesvirus_5_strain_Merlin_g_5 41515 212_Human_herpesvirus_5_strain_Merlin_g_1 41516 213_Human_herpesvirus_5_strain_Merlin_g_1 41517 213_Human_herpesvirus_5_strain_Merlin_g_2 41518 214_Human_herpesvirus_5_strain_Merlin_g_1 41519 214_Human_herpesvirus_5_strain_Merlin_g_2 41520 214_Human_herpesvirus_5_strain_Merlin_g_3 41521 214_Human_herpesvirus_5_strain_Merlin_g_4 41522 214_Human_herpesvirus_5_strain_Merlin_g_5 41523 215_Human_herpesvirus_5_strain_Merlin_g_1 41524 215_Human_herpesvirus_5_strain_Merlin_g_2 41525 215_Human_herpesvirus_5_strain_Merlin_g_3 41526 215_Human_herpesvirus_5_strain_Merlin_g_4 41527 216_Human_herpesvirus_5_strain_Merlin_g_1 41528 216_Human_herpesvirus_5_strain_Merlin_g_2 41529 216_Human_herpesvirus_5_strain_Merlin_g_3 41530 216_Human_herpesvirus_5_strain_Merlin_g_4 41531 216_Human_herpesvirus_5_strain_Merlin_g_5 41532 217_Human_herpesvirus_5_strain_Merlin_g_1 41533 217_Human_herpesvirus_5_strain_Merlin_g_2 41534 217_Human_herpesvirus_5_strain_Merlin_g_3 41535 217_Human_herpesvirus_5_strain_Merlin_g_4 41536 217_Human_herpesvirus_5_strain_Merlin_g_5 41537 218_Human_herpesvirus_5_strain_Merlin_g_1 41538 218_Human_herpesvirus_5_strain_Merlin_g_2 41539 218_Human_herpesvirus_5_strain_Merlin_g_3 41540 218_Human_herpesvirus_5_strain_Merlin_g_4 41541 218_Human_herpesvirus_5_strain_Merlin_g_5 41542 219_Human_herpesvirus_5_strain_Merlin_g_1 41543 219_Human_herpesvirus_5_strain_Merlin_g_2 41544 219_Human_herpesvirus_5_strain_Merlin_g_3 41545 219_Human_herpesvirus_5_strain_Merlin_g_4 41546 219_Human_herpesvirus_5_strain_Merlin_g_5 41547 220_Human_herpesvirus_5_strain_Merlin_g_1 41548 220_Human_herpesvirus_5_strain_Merlin_g_2 41549 220_Human_herpesvirus_5_strain_Merlin_g_3 41550 220_Human_herpesvirus_5_strain_Merlin_g_4 41551 220_Human_herpesvirus_5_strain_Merlin_g_5 41552 221_Human_herpesvirus_5_strain_Merlin_g_1 41553 221_Human_herpesvirus_5_strain_Merlin_g_2 41554 221_Human_herpesvirus_5_strain_Merlin_g_3 41555 221_Human_herpesvirus_5_strain_Merlin_g_4 41556 221_Human_herpesvirus_5_strain_Merlin_g_5 41557 222_Human_herpesvirus_5_strain_Merlin_g_1 41558 222_Human_herpesvirus_5_strain_Merlin_g_2 41559 222_Human_herpesvirus_5_strain_Merlin_g_3 41560 223_Human_herpesvirus_5_strain_Merlin_g_1 41561 223_Human_herpesvirus_5_strain_Merlin_g_2 41562 223_Human_herpesvirus_5_strain_Merlin_g_3 41563 223_Human_herpesvirus_5_strain_Merlin_g_4 41564 223_Human_herpesvirus_5_strain_Merlin_g_5 41565 224_Human_herpesvirus_5_strain_Merlin_g_1 41566 224_Human_herpesvirus_5_strain_Merlin_g_2 41567 224_Human_herpesvirus_5_strain_Merlin_g_3 41568 225_Human_herpesvirus_5_strain_Merlin_g_1 41569 225_Human_herpesvirus_5_strain_Merlin_g_2 41570 225_Human_herpesvirus_5_strain_Merlin_g_3 41571 225_Human_herpesvirus_5_strain_Merlin_g_4 41572 225_Human_herpesvirus_5_strain_Merlin_g_5 41573 226_Human_herpesvirus_5_strain_Merlin_g_1 41574 226_Human_herpesvirus_5_strain_Merlin_g_2 41575 226_Human_herpesvirus_5_strain_Merlin_g_3 41576 226_Human_herpesvirus_5_strain_Merlin_g_4 41577 226_Human_herpesvirus_5_strain_Merlin_g_5 41578 227_Human_herpesvirus_5_strain_Merlin_g_1 41579 227_Human_herpesvirus_5_strain_Merlin_g_2 41580 227_Human_herpesvirus_5_strain_Merlin_g_3 41581 227_Human_herpesvirus_5_strain_Merlin_g_4 41582 227_Human_herpesvirus_5_strain_Merlin_g_5 41583 228_Human_herpesvirus_5_strain_Merlin_g_1 41584 228_Human_herpesvirus_5_strain_Merlin_g_2 41585 228_Human_herpesvirus_5_strain_Merlin_g_3 41586 228_Human_herpesvirus_5_strain_Merlin_g_4 41587 228_Human_herpesvirus_5_strain_Merlin_g_5 41588 229_Human_herpesvirus_5_strain_Merlin_g_1 41589 229_Human_herpesvirus_5_strain_Merlin_g_2 41590 229_Human_herpesvirus_5_strain_Merlin_g_3 41591 229_Human_herpesvirus_5_strain_Merlin_g_4 41592 229_Human_herpesvirus_5_strain_Merlin_g_5 41593 230_Human_herpesvirus_5_strain_Merlin_g_1 41594 230_Human_herpesvirus_5_strain_Merlin_g_2 41595 230_Human_herpesvirus_5_strain_Merlin_g_3 41596 230_Human_herpesvirus_5_strain_Merlin_g_4 41597 230_Human_herpesvirus_5_strain_Merlin_g_5 41598 231_Human_herpesvirus_5_strain_Merlin_g_1 41599 231_Human_herpesvirus_5_strain_Merlin_g_2 41600 232_Human_herpesvirus_5_strain_Merlin_g_1 41601 232_Human_herpesvirus_5_strain_Merlin_g_2 41602 232_Human_herpesvirus_5_strain_Merlin_g_3 41603 232_Human_herpesvirus_5_strain_Merlin_g_4 41604 232_Human_herpesvirus_5_strain_Merlin_g_5 41605 233_Human_herpesvirus_5_strain_Merlin_g_1 41606 233_Human_herpesvirus_5_strain_Merlin_g_2 41607 233_Human_herpesvirus_5_strain_Merlin_g_3 41608 233_Human_herpesvirus_5_strain_Merlin_g_4 41609 233_Human_herpesvirus_5_strain_Merlin_g_5 41610 235_Human_herpesvirus_5_strain_Merlin_g_1 41611 235_Human_herpesvirus_5_strain_Merlin_g_2 41612 235_Human_herpesvirus_5_strain_Merlin_g_3 41613 235_Human_herpesvirus_5_strain_Merlin_g_4 41614 235_Human_herpesvirus_5_strain_Merlin_g_5 41615 236_Human_herpesvirus_5_strain_Merlin_g_1 41616 236_Human_herpesvirus_5_strain_Merlin_g_2 41617 236_Human_herpesvirus_5_strain_Merlin_g_3 41618 236_Human_herpesvirus_5_strain_Merlin_g_4 41619 236_Human_herpesvirus_5_strain_Merlin_g_5 41620 237_Human_herpesvirus_5_strain_Merlin_g_1 41621 237_Human_herpesvirus_5_strain_Merlin_g_2 41622 237_Human_herpesvirus_5_strain_Merlin_g_3 41623 238_Human_herpesvirus_5_strain_Merlin_g_1 41624 238_Human_herpesvirus_5_strain_Merlin_g_2 41625 238_Human_herpesvirus_5_strain_Merlin_g_3 41626 238_Human_herpesvirus_5_strain_Merlin_g_4 41627 238_Human_herpesvirus_5_strain_Merlin_g_5 41628 239_Human_herpesvirus_5_strain_Merlin_g_1 41629 239_Human_herpesvirus_5_strain_Merlin_g_2 41630 239_Human_herpesvirus_5_strain_Merlin_g_3 41631 239_Human_herpesvirus_5_strain_Merlin_g_4 41632 239_Human_herpesvirus_5_strain_Merlin_g_5 41633 240_Human_herpesvirus_5_strain_Merlin_g_1 41634 240_Human_herpesvirus_5_strain_Merlin_g_2 41635 240_Human_herpesvirus_5_strain_Merlin_g_3 41636 240_Human_herpesvirus_5_strain_Merlin_g_4 41637 240_Human_herpesvirus_5_strain_Merlin_g_5 41638 241_Human_herpesvirus_5_strain_Merlin_g_1 41639 241_Human_herpesvirus_5_strain_Merlin_g_2 41640 241_Human_herpesvirus_5_strain_Merlin_g_3 41641 241_Human_herpesvirus_5_strain_Merlin_g_4 41642 241_Human_herpesvirus_5_strain_Merlin_g_5 41643 242_Human_herpesvirus_5_strain_Merlin_g_1 41644 242_Human_herpesvirus_5_strain_Merlin_g_2 41645 242_Human_herpesvirus_5_strain_Merlin_g_3 41646 242_Human_herpesvirus_5_strain_Merlin_g_4 41647 242_Human_herpesvirus_5_strain_Merlin_g_5 41648 243_Human_herpesvirus_5_strain_Merlin_g_1 41649 243_Human_herpesvirus_5_strain_Merlin_g_2 41650 243_Human_herpesvirus_5_strain_Merlin_g_3 41651 243_Human_herpesvirus_5_strain_Merlin_g_4 41652 244_Human_herpesvirus_5_strain_Merlin_g_1 41653 244_Human_herpesvirus_5_strain_Merlin_g_2 41654 244_Human_herpesvirus_5_strain_Merlin_g_3 41655 244_Human_herpesvirus_5_strain_Merlin_g_4 41656 244_Human_herpesvirus_5_strain_Merlin_g_5 41657 245_Human_herpesvirus_5_strain_Merlin_g_1 41658 245_Human_herpesvirus_5_strain_Merlin_g_2 41659 246_Human_herpesvirus_5_strain_Merlin_g_1 41660 246_Human_herpesvirus_5_strain_Merlin_g_2 41661 246_Human_herpesvirus_5_strain_Merlin_g_3 41662 246_Human_herpesvirus_5_strain_Merlin_g_4 41663 246_Human_herpesvirus_5_strain_Merlin_g_5 41664 247_Human_herpesvirus_5_strain_Merlin_g_1 41665 247_Human_herpesvirus_5_strain_Merlin_g_2 41666 248_Human_herpesvirus_5_strain_Merlin_g_1 41667 248_Human_herpesvirus_5_strain_Merlin_g_2 41668 248_Human_herpesvirus_5_strain_Merlin_g_3 41669 248_Human_herpesvirus_5_strain_Merlin_g_4 41670 248_Human_herpesvirus_5_strain_Merlin_g_5 41671 249_Human_herpesvirus_5_strain_Merlin_g_1 41672 249_Human_herpesvirus_5_strain_Merlin_g_2 41673 249_Human_herpesvirus_5_strain_Merlin_g_3 41674 249_Human_herpesvirus_5_strain_Merlin_g_4 41675 249_Human_herpesvirus_5_strain_Merlin_g_5 41676 250_Human_herpesvirus_5_strain_Merlin_g_1 41677 250_Human_herpesvirus_5_strain_Merlin_g_2 41678 250_Human_herpesvirus_5_strain_Merlin_g_3 41679 250_Human_herpesvirus_5_strain_Merlin_g_4 41680 251_Human_herpesvirus_5_strain_Merlin_g_1 41681 251_Human_herpesvirus_5_strain_Merlin_g_2 41682 251_Human_herpesvirus_5_strain_Merlin_g_3 41683 251_Human_herpesvirus_5_strain_Merlin_g_4 41684 251_Human_herpesvirus_5_strain_Merlin_g_5 41685 252_Human_herpesvirus_5_strain_Merlin_g_1 41686 252_Human_herpesvirus_5_strain_Merlin_g_2 41687 252_Human_herpesvirus_5_strain_Merlin_g_3 41688 252_Human_herpesvirus_5_strain_Merlin_g_4 41689 253_Human_herpesvirus_5_strain_Merlin_g_1 41690 253_Human_herpesvirus_5_strain_Merlin_g_2 41691 254_Human_herpesvirus_5_strain_Merlin_g_1 41692 254_Human_herpesvirus_5_strain_Merlin_g_2 41693 254_Human_herpesvirus_5_strain_Merlin_g_3 41694 254_Human_herpesvirus_5_strain_Merlin_g_4 41695 254_Human_herpesvirus_5_strain_Merlin_g_5 41696 255_Human_herpesvirus_5_strain_Merlin_g_1 41697 255_Human_herpesvirus_5_strain_Merlin_g_2 41698 255_Human_herpesvirus_5_strain_Merlin_g_3 41699 255_Human_herpesvirus_5_strain_Merlin_g_4 41700 256_Human_herpesvirus_5_strain_Merlin_g_1 41701 256_Human_herpesvirus_5_strain_Merlin_g_2 41702 256_Human_herpesvirus_5_strain_Merlin_g_3 41703 256_Human_herpesvirus_5_strain_Merlin_g_4 41704 256_Human_herpesvirus_5_strain_Merlin_g_5 41705 257_Human_herpesvirus_5_strain_Merlin_g_1 41706 257_Human_herpesvirus_5_strain_Merlin_g_2 41707 257_Human_herpesvirus_5_strain_Merlin_g_3 41708 258_Human_herpesvirus_5_strain_Merlin_g_1 41709 258_Human_herpesvirus_5_strain_Merlin_g_2 41710 258_Human_herpesvirus_5_strain_Merlin_g_3 41711 258_Human_herpesvirus_5_strain_Merlin_g_4 41712 259_Human_herpesvirus_5_strain_Merlin_g_1 41713 259_Human_herpesvirus_5_strain_Merlin_g_2 41714 259_Human_herpesvirus_5_strain_Merlin_g_3 41715 259_Human_herpesvirus_5_strain_Merlin_g_4 41716 259_Human_herpesvirus_5_strain_Merlin_g_5 41717 260_Human_herpesvirus_5_strain_Merlin_g_1 41718 260_Human_herpesvirus_5_strain_Merlin_g_2 41719 260_Human_herpesvirus_5_strain_Merlin_g_3 41720 260_Human_herpesvirus_5_strain_Merlin_g_4 41721 260_Human_herpesvirus_5_strain_Merlin_g_5 41722 261_Human_herpesvirus_5_strain_Merlin_g_1 41723 261_Human_herpesvirus_5_strain_Merlin_g_2 41724 261_Human_herpesvirus_5_strain_Merlin_g_3 41725 261_Human_herpesvirus_5_strain_Merlin_g_4 41726 261_Human_herpesvirus_5_strain_Merlin_g_5 41727 262_Human_herpesvirus_5_strain_Merlin_g_1 41728 262_Human_herpesvirus_5_strain_Merlin_g_2 41729 262_Human_herpesvirus_5_strain_Merlin_g_3 41730 262_Human_herpesvirus_5_strain_Merlin_g_4 41731 262_Human_herpesvirus_5_strain_Merlin_g_5 41732 263_Human_herpesvirus_5_strain_Merlin_g_1 41733 263_Human_herpesvirus_5_strain_Merlin_g_2 41734 264_Human_herpesvirus_5_strain_Merlin_g_1 41735 264_Human_herpesvirus_5_strain_Merlin_g_2 41736 264_Human_herpesvirus_5_strain_Merlin_g_3 41737 265_Human_herpesvirus_5_strain_Merlin_g_1 41738 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341_Human_herpesvirus_5_strain_Merlin_g_3 42059 341_Human_herpesvirus_5_strain_Merlin_g_4 42060 341_Human_herpesvirus_5_strain_Merlin_g_5 42061 342_Human_herpesvirus_5_strain_Merlin_g_1 42062 342_Human_herpesvirus_5_strain_Merlin_g_2 42063 342_Human_herpesvirus_5_strain_Merlin_g_3 42064 342_Human_herpesvirus_5_strain_Merlin_g_4 42065 342_Human_herpesvirus_5_strain_Merlin_g_5 42066 343_Human_herpesvirus_5_strain_Merlin_g_1 42067 343_Human_herpesvirus_5_strain_Merlin_g_2 42068 343_Human_herpesvirus_5_strain_Merlin_g_3 42069 343_Human_herpesvirus_5_strain_Merlin_g_4 42070 343_Human_herpesvirus_5_strain_Merlin_g_5 42071 344_Human_herpesvirus_5_strain_Merlin_g_1 42072 344_Human_herpesvirus_5_strain_Merlin_g_2 42073 344_Human_herpesvirus_5_strain_Merlin_g_3 42074 344_Human_herpesvirus_5_strain_Merlin_g_4 42075 344_Human_herpesvirus_5_strain_Merlin_g_5 42076 345_Human_herpesvirus_5_strain_Merlin_g_1 42077 345_Human_herpesvirus_5_strain_Merlin_g_2 42078 345_Human_herpesvirus_5_strain_Merlin_g_3 42079 345_Human_herpesvirus_5_strain_Merlin_g_4 42080 345_Human_herpesvirus_5_strain_Merlin_g_5 42081 346_Human_herpesvirus_5_strain_Merlin_g_1 42082 346_Human_herpesvirus_5_strain_Merlin_g_2 42083 346_Human_herpesvirus_5_strain_Merlin_g_3 42084 346_Human_herpesvirus_5_strain_Merlin_g_4 42085 347_Human_herpesvirus_5_strain_Merlin_g_1 42086 347_Human_herpesvirus_5_strain_Merlin_g_2 42087 348_Human_herpesvirus_5_strain_Merlin_g_1 42088 348_Human_herpesvirus_5_strain_Merlin_g_2 42089 348_Human_herpesvirus_5_strain_Merlin_g_3 42090 348_Human_herpesvirus_5_strain_Merlin_g_4 42091 348_Human_herpesvirus_5_strain_Merlin_g_5 42092 349_Human_herpesvirus_5_strain_Merlin_g_1 42093 349_Human_herpesvirus_5_strain_Merlin_g_2 42094 349_Human_herpesvirus_5_strain_Merlin_g_3 42095 350_Human_herpesvirus_5_strain_Merlin_g_1 42096 350_Human_herpesvirus_5_strain_Merlin_g_2 42097 350_Human_herpesvirus_5_strain_Merlin_g_3 42098 350_Human_herpesvirus_5_strain_Merlin_g_4 42099 350_Human_herpesvirus_5_strain_Merlin_g_5 42100 351_Human_herpesvirus_5_strain_Merlin_g_1 42101 351_Human_herpesvirus_5_strain_Merlin_g_2 42102 351_Human_herpesvirus_5_strain_Merlin_g_3 42103 352_Human_herpesvirus_5_strain_Merlin_g_1 42104 352_Human_herpesvirus_5_strain_Merlin_g_2 42105 352_Human_herpesvirus_5_strain_Merlin_g_3 42106 352_Human_herpesvirus_5_strain_Merlin_g_4 42107 352_Human_herpesvirus_5_strain_Merlin_g_5 42108 353_Human_herpesvirus_5_strain_Merlin_g_1 42109 353_Human_herpesvirus_5_strain_Merlin_g_2 42110 353_Human_herpesvirus_5_strain_Merlin_g_3 42111 354_Human_herpesvirus_5_strain_Merlin_g_1 42112 354_Human_herpesvirus_5_strain_Merlin_g_2 42113 354_Human_herpesvirus_5_strain_Merlin_g_3 42114 354_Human_herpesvirus_5_strain_Merlin_g_4 42115 354_Human_herpesvirus_5_strain_Merlin_g_5 42116 355_Human_herpesvirus_5_strain_Merlin_g_1 42117 355_Human_herpesvirus_5_strain_Merlin_g_2 42118 355_Human_herpesvirus_5_strain_Merlin_g_3 42119 355_Human_herpesvirus_5_strain_Merlin_g_4 42120 355_Human_herpesvirus_5_strain_Merlin_g_5 42121 356_Influenza_A_virus_pa_gene_for_polymerase_PA_g_1 42122 356_Influenza_A_virus_pa_gene_for_polymerase_PA_g_2 42123 356_Influenza_A_virus_pa_gene_for_polymerase_PA_g_3 42124 356_Influenza_A_virus_pa_gene_for_polymerase_PA_g_4 42125 356_Influenza_A_virus_pa_gene_for_polymerase_PA_g_5 42126 357_Influenza_A_virus_pa_gene_for_polymerase_PA_g_1 42127 357_Influenza_A_virus_pa_gene_for_polymerase_PA_g_2 42128 357_Influenza_A_virus_pa_gene_for_polymerase_PA_g_3 42129 357_Influenza_A_virus_pa_gene_for_polymerase_PA_g_4 42130 357_Influenza_A_virus_pa_gene_for_polymerase_PA_g_5 42131 358_Influenza_A_virus_pa_gene_for_polymerase_PA_g_1 42132 358_Influenza_A_virus_pa_gene_for_polymerase_PA_g_2 42133 358_Influenza_A_virus_pa_gene_for_polymerase_PA_g_3 42134 358_Influenza_A_virus_pa_gene_for_polymerase_PA_g_4 42135 358_Influenza_A_virus_pa_gene_for_polymerase_PA_g_5 42136 359_Influenza_A_virus_pa_gene_for_polymerase_PA_g_1 42137 359_Influenza_A_virus_pa_gene_for_polymerase_PA_g_2 42138 359_Influenza_A_virus_pa_gene_for_polymerase_PA_g_3 42139 359_Influenza_A_virus_pa_gene_for_polymerase_PA_g_4 42140 359_Influenza_A_virus_pa_gene_for_polymerase_PA_g_5 42141 360_Influenza_A_virus_pa_gene_for_polymerase_PA_g_1 42142 360_Influenza_A_virus_pa_gene_for_polymerase_PA_g_2 42143 360_Influenza_A_virus_pa_gene_for_polymerase_PA_g_3 42144 360_Influenza_A_virus_pa_gene_for_polymerase_PA_g_4 42145 360_Influenza_A_virus_pa_gene_for_polymerase_PA_g_5 42146 361_Influenza_A_virus_pa_gene_for_polymerase_PA_g_1 42147 361_Influenza_A_virus_pa_gene_for_polymerase_PA_g_2 42148 361_Influenza_A_virus_pa_gene_for_polymerase_PA_g_3 42149 361_Influenza_A_virus_pa_gene_for_polymerase_PA_g_4 42150 361_Influenza_A_virus_pa_gene_for_polymerase_PA_g_5 42151 362_Influenza_A_virus_pa_gene_for_polymerase_PA_g_1 42152 362_Influenza_A_virus_pa_gene_for_polymerase_PA_g_2 42153 362_Influenza_A_virus_pa_gene_for_polymerase_PA_g_3 42154 362_Influenza_A_virus_pa_gene_for_polymerase_PA_g_4 42155 362_Influenza_A_virus_pa_gene_for_polymerase_PA_g_5 42156 363_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42157 segment_5_nucleocapsid_protein_(NP)_gene_g_1 363_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42158 segment_5_nucleocapsid_protein_(NP)_gene_g_2 363_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42159 segment_5_nucleocapsid_protein_(NP)_gene_g_3 363_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42160 segment_5_nucleocapsid_protein_(NP)_gene_g_4 363_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42161 segment_5_nucleocapsid_protein_(NP)_gene_g_5 364_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42162 segment_5_nucleocapsid_protein_(NP)_gene_g_1 364_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42163 segment_5_nucleocapsid_protein_(NP)_gene_g_2 364_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42164 segment_5_nucleocapsid_protein_(NP)_gene_g_3 364_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42165 segment_5_nucleocapsid_protein_(NP)_gene_g_4 364_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42166 segment_5_nucleocapsid_protein_(NP)_gene_g_5 365_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42167 segment_5_nucleocapsid_protein_(NP)_gene_g_1 365_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42168 segment_5_nucleocapsid_protein_(NP)_gene_g_2 365_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42169 segment_5_nucleocapsid_protein_(NP)_gene_g_3 365_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42170 segment_5_nucleocapsid_protein_(NP)_gene_g_4 365_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42171 segment_5_nucleocapsid_protein_(NP)_gene_g_5 366_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42172 segment_5_nucleocapsid_protein_(NP)_gene_g_1 366_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42173 segment_5_nucleocapsid_protein_(NP)_gene_g_2 366_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42174 segment_5_nucleocapsid_protein_(NP)_gene_g_3 366_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42175 segment_5_nucleocapsid_protein_(NP)_gene_g_4 366_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 42176 segment_5_nucleocapsid_protein_(NP)_gene_g_5 367_Human_adenovirus_A_g_1 42177 367_Human_adenovirus_A_g_2 42178 367_Human_adenovirus_A_g_3 42179 367_Human_adenovirus_A_g_4 42180 367_Human_adenovirus_A_g_5 42181 368_Human_adenovirus_A_g_1 42182 368_Human_adenovirus_A_g_2 42183 368_Human_adenovirus_A_g_3 42184 368_Human_adenovirus_A_g_4 42185 368_Human_adenovirus_A_g_5 42186 369_Human_adenovirus_A_g_1 42187 369_Human_adenovirus_A_g_2 42188 369_Human_adenovirus_A_g_3 42189 369_Human_adenovirus_A_g_4 42190 369_Human_adenovirus_A_g_5 42191 370_Human_adenovirus_A_g_1 42192 370_Human_adenovirus_A_g_2 42193 370_Human_adenovirus_A_g_3 42194 370_Human_adenovirus_A_g_4 42195 370_Human_adenovirus_A_g_5 42196 371_Human_adenovirus_A_g_1 42197 371_Human_adenovirus_A_g_2 42198 371_Human_adenovirus_A_g_3 42199 371_Human_adenovirus_A_g_4 42200 371_Human_adenovirus_A_g_5 42201 372_Human_adenovirus_A_g_1 42202 372_Human_adenovirus_A_g_2 42203 372_Human_adenovirus_A_g_3 42204 372_Human_adenovirus_A_g_4 42205 372_Human_adenovirus_A_g_5 42206 373_Human_adenovirus_A_g_1 42207 373_Human_adenovirus_A_g_2 42208 373_Human_adenovirus_A_g_3 42209 373_Human_adenovirus_A_g_4 42210 373_Human_adenovirus_A_g_5 42211 374_Human_adenovirus_A_g_1 42212 374_Human_adenovirus_A_g_2 42213 374_Human_adenovirus_A_g_3 42214 374_Human_adenovirus_A_g_4 42215 374_Human_adenovirus_A_g_5 42216 375_Human_adenovirus_A_g_1 42217 375_Human_adenovirus_A_g_2 42218 375_Human_adenovirus_A_g_3 42219 375_Human_adenovirus_A_g_4 42220 375_Human_adenovirus_A_g_5 42221 376_Human_adenovirus_A_g_1 42222 376_Human_adenovirus_A_g_2 42223 376_Human_adenovirus_A_g_3 42224 376_Human_adenovirus_A_g_4 42225 376_Human_adenovirus_A_g_5 42226 377_Human_adenovirus_A_g_1 42227 377_Human_adenovirus_A_g_2 42228 377_Human_adenovirus_A_g_3 42229 377_Human_adenovirus_A_g_4 42230 377_Human_adenovirus_A_g_5 42231 378_Human_adenovirus_A_g_1 42232 378_Human_adenovirus_A_g_2 42233 378_Human_adenovirus_A_g_3 42234 378_Human_adenovirus_A_g_4 42235 378_Human_adenovirus_A_g_5 42236 379_Human_adenovirus_A_g_1 42237 379_Human_adenovirus_A_g_2 42238 379_Human_adenovirus_A_g_3 42239 379_Human_adenovirus_A_g_4 42240 379_Human_adenovirus_A_g_5 42241 380_Human_adenovirus_A_g_1 42242 380_Human_adenovirus_A_g_2 42243 380_Human_adenovirus_A_g_3 42244 380_Human_adenovirus_A_g_4 42245 380_Human_adenovirus_A_g_5 42246 381_Human_adenovirus_A_g_1 42247 381_Human_adenovirus_A_g_2 42248 381_Human_adenovirus_A_g_3 42249 381_Human_adenovirus_A_g_4 42250 381_Human_adenovirus_A_g_5 42251 382_Human_adenovirus_A_g_1 42252 382_Human_adenovirus_A_g_2 42253 382_Human_adenovirus_A_g_3 42254 382_Human_adenovirus_A_g_4 42255 382_Human_adenovirus_A_g_5 42256 383_Human_adenovirus_A_g_1 42257 383_Human_adenovirus_A_g_2 42258 383_Human_adenovirus_A_g_3 42259 383_Human_adenovirus_A_g_4 42260 383_Human_adenovirus_A_g_5 42261 384_Human_adenovirus_A_g_1 42262 384_Human_adenovirus_A_g_2 42263 384_Human_adenovirus_A_g_3 42264 384_Human_adenovirus_A_g_4 42265 384_Human_adenovirus_A_g_5 42266 385_Human_adenovirus_A_g_1 42267 385_Human_adenovirus_A_g_2 42268 385_Human_adenovirus_A_g_3 42269 385_Human_adenovirus_A_g_4 42270 385_Human_adenovirus_A_g_5 42271 386_Human_adenovirus_A_g_1 42272 386_Human_adenovirus_A_g_2 42273 386_Human_adenovirus_A_g_3 42274 386_Human_adenovirus_A_g_4 42275 386_Human_adenovirus_A_g_5 42276 387_Human_adenovirus_A_g_1 42277 387_Human_adenovirus_A_g_2 42278 387_Human_adenovirus_A_g_3 42279 387_Human_adenovirus_A_g_4 42280 387_Human_adenovirus_A_g_5 42281 388_Human_adenovirus_A_g_1 42282 388_Human_adenovirus_A_g_2 42283 388_Human_adenovirus_A_g_3 42284 388_Human_adenovirus_A_g_4 42285 388_Human_adenovirus_A_g_5 42286 389_Human_adenovirus_A_g_1 42287 389_Human_adenovirus_A_g_2 42288 389_Human_adenovirus_A_g_3 42289 389_Human_adenovirus_A_g_4 42290 389_Human_adenovirus_A_g_5 42291 390_Human_adenovirus_A_g_1 42292 390_Human_adenovirus_A_g_2 42293 390_Human_adenovirus_A_g_3 42294 390_Human_adenovirus_A_g_4 42295 390_Human_adenovirus_A_g_5 42296 391_Human_adenovirus_A_g_1 42297 391_Human_adenovirus_A_g_2 42298 391_Human_adenovirus_A_g_3 42299 391_Human_adenovirus_A_g_4 42300 391_Human_adenovirus_A_g_5 42301 392_Human_adenovirus_A_g_1 42302 392_Human_adenovirus_A_g_2 42303 392_Human_adenovirus_A_g_3 42304 392_Human_adenovirus_A_g_4 42305 392_Human_adenovirus_A_g_5 42306 393_Human_adenovirus_A_g_1 42307 393_Human_adenovirus_A_g_2 42308 393_Human_adenovirus_A_g_3 42309 393_Human_adenovirus_A_g_4 42310 393_Human_adenovirus_A_g_5 42311 394_Human_adenovirus_A_g_1 42312 394_Human_adenovirus_A_g_2 42313 394_Human_adenovirus_A_g_3 42314 394_Human_adenovirus_A_g_4 42315 394_Human_adenovirus_A_g_5 42316 395_Human_adenovirus_A_g_1 42317 395_Human_adenovirus_A_g_2 42318 395_Human_adenovirus_A_g_3 42319 395_Human_adenovirus_A_g_4 42320 395_Human_adenovirus_A_g_5 42321 396_Human_adenovirus_A_g_1 42322 396_Human_adenovirus_A_g_2 42323 396_Human_adenovirus_A_g_3 42324 396_Human_adenovirus_A_g_4 42325 396_Human_adenovirus_A_g_5 42326 397_Human_adenovirus_A_g_1 42327 397_Human_adenovirus_A_g_2 42328 397_Human_adenovirus_A_g_3 42329 397_Human_adenovirus_A_g_4 42330 397_Human_adenovirus_A_g_5 42331 398_Human_adenovirus_A_g_1 42332 398_Human_adenovirus_A_g_2 42333 398_Human_adenovirus_A_g_3 42334 398_Human_adenovirus_A_g_4 42335 398_Human_adenovirus_A_g_5 42336 399_Human_adenovirus_A_g_1 42337 399_Human_adenovirus_A_g_2 42338 399_Human_adenovirus_A_g_3 42339 399_Human_adenovirus_A_g_4 42340 399_Human_adenovirus_A_g_5 42341 400_Human_adenovirus_A_g_1 42342 400_Human_adenovirus_A_g_2 42343 400_Human_adenovirus_A_g_3 42344 400_Human_adenovirus_A_g_4 42345 400_Human_adenovirus_A_g_5 42346 401_Human_adenovirus_A_g_1 42347 401_Human_adenovirus_A_g_2 42348 401_Human_adenovirus_A_g_3 42349 401_Human_adenovirus_A_g_4 42350 401_Human_adenovirus_A_g_5 42351 402_Human_adenovirus_A_g_1 42352 402_Human_adenovirus_A_g_2 42353 402_Human_adenovirus_A_g_3 42354 402_Human_adenovirus_A_g_4 42355 402_Human_adenovirus_A_g_5 42356 403_Human_adenovirus_A_g_1 42357 403_Human_adenovirus_A_g_2 42358 403_Human_adenovirus_A_g_3 42359 403_Human_adenovirus_A_g_4 42360 403_Human_adenovirus_A_g_5 42361 404_Human_adenovirus_A_g_1 42362 404_Human_adenovirus_A_g_2 42363 404_Human_adenovirus_A_g_3 42364 404_Human_adenovirus_A_g_4 42365 404_Human_adenovirus_A_g_5 42366 405_Human_adenovirus_A_g_1 42367 405_Human_adenovirus_A_g_2 42368 405_Human_adenovirus_A_g_3 42369 405_Human_adenovirus_A_g_4 42370 405_Human_adenovirus_A_g_5 42371 406_Human_adenovirus_A_g_1 42372 406_Human_adenovirus_A_g_2 42373 406_Human_adenovirus_A_g_3 42374 406_Human_adenovirus_A_g_4 42375 406_Human_adenovirus_A_g_5 42376 407_Human_adenovirus_A_g_1 42377 407_Human_adenovirus_A_g_2 42378 407_Human_adenovirus_A_g_3 42379 407_Human_adenovirus_A_g_4 42380 407_Human_adenovirus_A_g_5 42381 408_Human_adenovirus_A_g_1 42382 408_Human_adenovirus_A_g_2 42383 408_Human_adenovirus_A_g_3 42384 408_Human_adenovirus_A_g_4 42385 408_Human_adenovirus_A_g_5 42386 409_Human_adenovirus_A_g_1 42387 409_Human_adenovirus_A_g_2 42388 409_Human_adenovirus_A_g_3 42389 409_Human_adenovirus_A_g_4 42390 409_Human_adenovirus_A_g_5 42391 410_Human_adenovirus_A_g_1 42392 410_Human_adenovirus_A_g_2 42393 410_Human_adenovirus_A_g_3 42394 410_Human_adenovirus_A_g_4 42395 410_Human_adenovirus_A_g_5 42396 411_Human_adenovirus_A_g_1 42397 411_Human_adenovirus_A_g_2 42398 411_Human_adenovirus_A_g_3 42399 411_Human_adenovirus_A_g_4 42400 411_Human_adenovirus_A_g_5 42401 412_Human_adenovirus_A_g_1 42402 412_Human_adenovirus_A_g_2 42403 412_Human_adenovirus_A_g_3 42404 412_Human_adenovirus_A_g_4 42405 412_Human_adenovirus_A_g_5 42406 413_Human_adenovirus_A_g_1 42407 413_Human_adenovirus_A_g_2 42408 413_Human_adenovirus_A_g_3 42409 413_Human_adenovirus_A_g_4 42410 413_Human_adenovirus_A_g_5 42411 414_Human_adenovirus_A_g_1 42412 414_Human_adenovirus_A_g_2 42413 414_Human_adenovirus_A_g_3 42414 415_Human_adenovirus_A_g_1 42415 415_Human_adenovirus_A_g_2 42416 415_Human_adenovirus_A_g_3 42417 415_Human_adenovirus_A_g_4 42418 415_Human_adenovirus_A_g_5 42419 416_Human_adenovirus_A_g_1 42420 416_Human_adenovirus_A_g_2 42421 416_Human_adenovirus_A_g_3 42422 416_Human_adenovirus_A_g_4 42423 416_Human_adenovirus_A_g_5 42424 417_Human_adenovirus_A_g_1 42425 417_Human_adenovirus_A_g_2 42426 417_Human_adenovirus_A_g_3 42427 417_Human_adenovirus_A_g_4 42428 417_Human_adenovirus_A_g_5 42429 418_Human_adenovirus_A_g_1 42430 418_Human_adenovirus_A_g_2 42431 418_Human_adenovirus_A_g_3 42432 418_Human_adenovirus_A_g_4 42433 418_Human_adenovirus_A_g_5 42434 419_Human_adenovirus_A_g_1 42435 419_Human_adenovirus_A_g_2 42436 419_Human_adenovirus_A_g_3 42437 419_Human_adenovirus_A_g_4 42438 419_Human_adenovirus_A_g_5 42439 420_Human_adenovirus_A_g_1 42440 420_Human_adenovirus_A_g_2 42441 420_Human_adenovirus_A_g_3 42442 420_Human_adenovirus_A_g_4 42443 420_Human_adenovirus_A_g_5 42444 421_Human_adenovirus_A_g_1 42445 421_Human_adenovirus_A_g_2 42446 421_Human_adenovirus_A_g_3 42447 421_Human_adenovirus_A_g_4 42448 421_Human_adenovirus_A_g_5 42449 422_Human_adenovirus_A_g_1 42450 422_Human_adenovirus_A_g_2 42451 422_Human_adenovirus_A_g_3 42452 422_Human_adenovirus_A_g_4 42453 422_Human_adenovirus_A_g_5 42454 423_Human_adenovirus_A_g_1 42455 423_Human_adenovirus_A_g_2 42456 423_Human_adenovirus_A_g_3 42457 423_Human_adenovirus_A_g_4 42458 423_Human_adenovirus_A_g_5 42459 424_Human_adenovirus_A_g_1 42460 424_Human_adenovirus_A_g_2 42461 424_Human_adenovirus_A_g_3 42462 424_Human_adenovirus_A_g_4 42463 424_Human_adenovirus_A_g_5 42464 425_Human_adenovirus_A_g_1 42465 425_Human_adenovirus_A_g_2 42466 425_Human_adenovirus_A_g_3 42467 425_Human_adenovirus_A_g_4 42468 425_Human_adenovirus_A_g_5 42469 426_Human_adenovirus_A_g_1 42470 426_Human_adenovirus_A_g_2 42471 426_Human_adenovirus_A_g_3 42472 426_Human_adenovirus_A_g_4 42473 426_Human_adenovirus_A_g_5 42474 427_Human_adenovirus_A_g_1 42475 427_Human_adenovirus_A_g_2 42476 427_Human_adenovirus_A_g_3 42477 427_Human_adenovirus_A_g_4 42478 427_Human_adenovirus_A_g_5 42479 428_Human_adenovirus_A_g_1 42480 428_Human_adenovirus_A_g_2 42481 428_Human_adenovirus_A_g_3 42482 428_Human_adenovirus_A_g_4 42483 428_Human_adenovirus_A_g_5 42484 429_Human_adenovirus_A_g_1 42485 429_Human_adenovirus_A_g_2 42486 429_Human_adenovirus_A_g_3 42487 429_Human_adenovirus_A_g_4 42488 429_Human_adenovirus_A_g_5 42489 430_Human_adenovirus_A_g_1 42490 430_Human_adenovirus_A_g_2 42491 430_Human_adenovirus_A_g_3 42492 430_Human_adenovirus_A_g_4 42493 430_Human_adenovirus_A_g_5 42494 431_Human_adenovirus_A_g_1 42495 431_Human_adenovirus_A_g_2 42496 431_Human_adenovirus_A_g_3 42497 431_Human_adenovirus_A_g_4 42498 431_Human_adenovirus_A_g_5 42499 432_Human_adenovirus_A_g_1 42500 432_Human_adenovirus_A_g_2 42501 432_Human_adenovirus_A_g_3 42502 432_Human_adenovirus_A_g_4 42503 432_Human_adenovirus_A_g_5 42504 433_Human_adenovirus_A_g_1 42505 433_Human_adenovirus_A_g_2 42506 433_Human_adenovirus_A_g_3 42507 433_Human_adenovirus_A_g_4 42508 433_Human_adenovirus_A_g_5 42509 434_Human_adenovirus_A_g_1 42510 434_Human_adenovirus_A_g_2 42511 434_Human_adenovirus_A_g_3 42512 434_Human_adenovirus_A_g_4 42513 434_Human_adenovirus_A_g_5 42514 435_Human_adenovirus_A_g_1 42515 435_Human_adenovirus_A_g_2 42516 435_Human_adenovirus_A_g_3 42517 435_Human_adenovirus_A_g_4 42518 435_Human_adenovirus_A_g_5 42519 436_Human_adenovirus_A_g_1 42520 436_Human_adenovirus_A_g_2 42521 436_Human_adenovirus_A_g_3 42522 436_Human_adenovirus_A_g_4 42523 436_Human_adenovirus_A_g_5 42524 437_Human_adenovirus_A_g_1 42525 437_Human_adenovirus_A_g_2 42526 437_Human_adenovirus_A_g_3 42527 437_Human_adenovirus_A_g_4 42528 437_Human_adenovirus_A_g_5 42529 438_Human_adenovirus_A_g_1 42530 438_Human_adenovirus_A_g_2 42531 438_Human_adenovirus_A_g_3 42532 438_Human_adenovirus_A_g_4 42533 438_Human_adenovirus_A_g_5 42534 439_Human_adenovirus_A_g_1 42535 439_Human_adenovirus_A_g_2 42536 439_Human_adenovirus_A_g_3 42537 439_Human_adenovirus_A_g_4 42538 439_Human_adenovirus_A_g_5 42539 440_Human_adenovirus_A_g_1 42540 440_Human_adenovirus_A_g_2 42541 440_Human_adenovirus_A_g_3 42542 440_Human_adenovirus_A_g_4 42543 440_Human_adenovirus_A_g_5 42544 441_Human_adenovirus_A_g_1 42545 441_Human_adenovirus_A_g_2 42546 441_Human_adenovirus_A_g_3 42547 441_Human_adenovirus_A_g_4 42548 441_Human_adenovirus_A_g_5 42549 442_Human_adenovirus_A_g_1 42550 442_Human_adenovirus_A_g_2 42551 442_Human_adenovirus_A_g_3 42552 442_Human_adenovirus_A_g_4 42553 442_Human_adenovirus_A_g_5 42554 443_Human_adenovirus_A_g_1 42555 443_Human_adenovirus_A_g_2 42556 443_Human_adenovirus_A_g_3 42557 443_Human_adenovirus_A_g_4 42558 443_Human_adenovirus_A_g_5 42559 444_Human_adenovirus_A_g_1 42560 444_Human_adenovirus_A_g_2 42561 444_Human_adenovirus_A_g_3 42562 444_Human_adenovirus_A_g_4 42563 444_Human_adenovirus_A_g_5 42564 445_Human_adenovirus_A_g_1 42565 445_Human_adenovirus_A_g_2 42566 445_Human_adenovirus_A_g_3 42567 445_Human_adenovirus_A_g_4 42568 445_Human_adenovirus_A_g_5 42569 446_Human_adenovirus_A_g_1 42570 446_Human_adenovirus_A_g_2 42571 446_Human_adenovirus_A_g_3 42572 446_Human_adenovirus_A_g_4 42573 446_Human_adenovirus_A_g_5 42574 447_Human_adenovirus_A_g_1 42575 447_Human_adenovirus_A_g_2 42576 447_Human_adenovirus_A_g_3 42577 447_Human_adenovirus_A_g_4 42578 447_Human_adenovirus_A_g_5 42579 448_Human_adenovirus_A_g_1 42580 448_Human_adenovirus_A_g_2 42581 448_Human_adenovirus_A_g_3 42582 448_Human_adenovirus_A_g_4 42583 448_Human_adenovirus_A_g_5 42584 449_Human_adenovirus_A_g_1 42585 449_Human_adenovirus_A_g_2 42586 449_Human_adenovirus_A_g_3 42587 449_Human_adenovirus_A_g_4 42588 449_Human_adenovirus_A_g_5 42589 450_Human_adenovirus_A_g_1 42590 450_Human_adenovirus_A_g_2 42591 450_Human_adenovirus_A_g_3 42592 450_Human_adenovirus_A_g_4 42593 450_Human_adenovirus_A_g_5 42594 451_Human_adenovirus_A_g_1 42595 451_Human_adenovirus_A_g_2 42596 451_Human_adenovirus_A_g_3 42597 451_Human_adenovirus_A_g_4 42598 451_Human_adenovirus_A_g_5 42599 452_Human_adenovirus_A_g_1 42600 452_Human_adenovirus_A_g_2 42601 452_Human_adenovirus_A_g_3 42602 452_Human_adenovirus_A_g_4 42603 452_Human_adenovirus_A_g_5 42604 453_Human_adenovirus_A_g_1 42605 453_Human_adenovirus_A_g_2 42606 453_Human_adenovirus_A_g_3 42607 453_Human_adenovirus_A_g_4 42608 453_Human_adenovirus_A_g_5 42609 454_Human_adenovirus_A_g_1 42610 454_Human_adenovirus_A_g_2 42611 454_Human_adenovirus_A_g_3 42612 454_Human_adenovirus_A_g_4 42613 454_Human_adenovirus_A_g_5 42614 455_Human_adenovirus_A_g_1 42615 455_Human_adenovirus_A_g_2 42616 455_Human_adenovirus_A_g_3 42617 455_Human_adenovirus_A_g_4 42618 455_Human_adenovirus_A_g_5 42619 456_Human_adenovirus_A_g_1 42620 456_Human_adenovirus_A_g_2 42621 456_Human_adenovirus_A_g_3 42622 456_Human_adenovirus_A_g_4 42623 456_Human_adenovirus_A_g_5 42624 457_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42625 457_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42626 457_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42627 457_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42628 457_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42629 458_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42630 458_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42631 458_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42632 458_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42633 458_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42634 459_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42635 459_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42636 459_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42637 459_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42638 459_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42639 460_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42640 460_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42641 460_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42642 460_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42643 460_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42644 461_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42645 461_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42646 461_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42647 461_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42648 461_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42649 462_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42650 462_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42651 462_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42652 462_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42653 462_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42654 463_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42655 463_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42656 463_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42657 463_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42658 463_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42659 464_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42660 464_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42661 464_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42662 464_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42663 464_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42664 465_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42665 465_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42666 465_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42667 465_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42668 465_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42669 466_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42670 466_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42671 466_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42672 466_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42673 466_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42674 467_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42675 467_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42676 467_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42677 467_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42678 467_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42679 468_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42680 468_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42681 468_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42682 468_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42683 468_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42684 469_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42685 469_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42686 469_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42687 469_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42688 469_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42689 470_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42690 470_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42691 470_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42692 470_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42693 470_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42694 471_Human_rhinovirus_NAT001_polyprotein_gene_g_1 42695 471_Human_rhinovirus_NAT001_polyprotein_gene_g_2 42696 471_Human_rhinovirus_NAT001_polyprotein_gene_g_3 42697 471_Human_rhinovirus_NAT001_polyprotein_gene_g_4 42698 471_Human_rhinovirus_NAT001_polyprotein_gene_g_5 42699 472_Human_papillomavirus_type_4_g_1 42700 472_Human_papillomavirus_type_4_g_2 42701 472_Human_papillomavirus_type_4_g_3 42702 472_Human_papillomavirus_type_4_g_4 42703 472_Human_papillomavirus_type_4_g_5 42704 473_Human_papillomavirus_type_4_g_1 42705 473_Human_papillomavirus_type_4_g_2 42706 473_Human_papillomavirus_type_4_g_3 42707 473_Human_papillomavirus_type_4_g_4 42708 473_Human_papillomavirus_type_4_g_5 42709 474_Human_papillomavirus_type_4_g_1 42710 474_Human_papillomavirus_type_4_g_2 42711 474_Human_papillomavirus_type_4_g_3 42712 474_Human_papillomavirus_type_4_g_4 42713 474_Human_papillomavirus_type_4_g_5 42714 475_Human_papillomavirus_type_4_g_1 42715 475_Human_papillomavirus_type_4_g_2 42716 475_Human_papillomavirus_type_4_g_3 42717 475_Human_papillomavirus_type_4_g_4 42718 475_Human_papillomavirus_type_4_g_5 42719 476_Human_papillomavirus_type_4_g_1 42720 476_Human_papillomavirus_type_4_g_2 42721 476_Human_papillomavirus_type_4_g_3 42722 476_Human_papillomavirus_type_4_g_4 42723 476_Human_papillomavirus_type_4_g_5 42724 477_Human_papillomavirus_type_4_g_1 42725 477_Human_papillomavirus_type_4_g_2 42726 477_Human_papillomavirus_type_4_g_3 42727 477_Human_papillomavirus_type_4_g_4 42728 477_Human_papillomavirus_type_4_g_5 42729 478_Human_papillomavirus_type_4_g_1 42730 478_Human_papillomavirus_type_4_g_2 42731 478_Human_papillomavirus_type_4_g_3 42732 478_Human_papillomavirus_type_4_g_4 42733 478_Human_papillomavirus_type_4_g_5 42734 479_Human_papillomavirus_type_4_g_1 42735 479_Human_papillomavirus_type_4_g_2 42736 479_Human_papillomavirus_type_4_g_3 42737 479_Human_papillomavirus_type_4_g_4 42738 479_Human_papillomavirus_type_4_g_5 42739 480_Human_papillomavirus_type_4_g_1 42740 480_Human_papillomavirus_type_4_g_2 42741 480_Human_papillomavirus_type_4_g_3 42742 480_Human_papillomavirus_type_4_g_4 42743 480_Human_papillomavirus_type_4_g_5 42744 481_Human_papillomavirus_type_4_g_1 42745 481_Human_papillomavirus_type_4_g_2 42746 481_Human_papillomavirus_type_4_g_3 42747 481_Human_papillomavirus_type_4_g_4 42748 481_Human_papillomavirus_type_4_g_5 42749 482_Human_papillomavirus_type_4_g_1 42750 482_Human_papillomavirus_type_4_g_2 42751 482_Human_papillomavirus_type_4_g_3 42752 482_Human_papillomavirus_type_4_g_4 42753 482_Human_papillomavirus_type_4_g_5 42754 483_Human_papillomavirus_type_4_g_1 42755 483_Human_papillomavirus_type_4_g_2 42756 483_Human_papillomavirus_type_4_g_3 42757 483_Human_papillomavirus_type_4_g_4 42758 483_Human_papillomavirus_type_4_g_5 42759 484_Human_papillomavirus_type_4_g_1 42760 484_Human_papillomavirus_type_4_g_2 42761 484_Human_papillomavirus_type_4_g_3 42762 484_Human_papillomavirus_type_4_g_4 42763 484_Human_papillomavirus_type_4_g_5 42764 485_Human_papillomavirus_type_4_g_1 42765 485_Human_papillomavirus_type_4_g_2 42766 485_Human_papillomavirus_type_4_g_3 42767 485_Human_papillomavirus_type_4_g_4 42768 485_Human_papillomavirus_type_4_g_5 42769 486_Human_papillomavirus_type_4_g_1 42770 486_Human_papillomavirus_type_4_g_2 42771 486_Human_papillomavirus_type_4_g_3 42772 486_Human_papillomavirus_type_4_g_4 42773 486_Human_papillomavirus_type_4_g_5 42774 487_Human_papillomavirus_type_4_g_1 42775 487_Human_papillomavirus_type_4_g_2 42776 487_Human_papillomavirus_type_4_g_3 42777 487_Human_papillomavirus_type_4_g_4 42778 487_Human_papillomavirus_type_4_g_5 42779 488_Human_papillomavirus_type_4_g_1 42780 488_Human_papillomavirus_type_4_g_2 42781 488_Human_papillomavirus_type_4_g_3 42782 488_Human_papillomavirus_type_4_g_4 42783 488_Human_papillomavirus_type_4_g_5 42784 489_Human_papillomavirus_type_4_g_1 42785 489_Human_papillomavirus_type_4_g_2 42786 489_Human_papillomavirus_type_4_g_3 42787 489_Human_papillomavirus_type_4_g_4 42788 489_Human_papillomavirus_type_4_g_5 42789 490_Human_herpesvirus_7_g_1 42790 491_Human_herpesvirus_7_g_1 42791 491_Human_herpesvirus_7_g_2 42792 491_Human_herpesvirus_7_g_3 42793 491_Human_herpesvirus_7_g_4 42794 491_Human_herpesvirus_7_g_5 42795 492_Human_herpesvirus_7_g_1 42796 492_Human_herpesvirus_7_g_2 42797 492_Human_herpesvirus_7_g_3 42798 492_Human_herpesvirus_7_g_4 42799 492_Human_herpesvirus_7_g_5 42800 493_Human_herpesvirus_7_g_1 42801 493_Human_herpesvirus_7_g_2 42802 493_Human_herpesvirus_7_g_3 42803 494_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42804 for_polymerase_1_g_1 494_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42805 for_polymerase_1_g_2 494_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42806 for_polymerase_1_g_3 494_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42807 for_polymerase_1_g_4 494_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42808 for_polymerase_1_g_5 495_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42809 for_polymerase_1_g_1 495_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42810 for_polymerase_1_g_2 495_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42811 for_polymerase_1_g_3 495_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42812 for_polymerase_1_g_4 495_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42813 for_polymerase_1_g_5 496_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42814 for_polymerase_1_g_1 496_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42815 for_polymerase_1_g_2 496_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42816 for_polymerase_1_g_3 496_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42817 for_polymerase_1_g_4 496_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42818 for_polymerase_1_g_5 497_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42819 for_polymerase_1_g_1 497_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42820 for_polymerase_1_g_2 497_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42821 for_polymerase_1_g_3 497_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42822 for_polymerase_1_g_4 497_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42823 for_polymerase_1_g_5 498_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42824 for_polymerase_1_g_1 498_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42825 for_polymerase_1_g_2 498_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42826 for_polymerase_1_g_3 498_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42827 for_polymerase_1_g_4 498_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB1_gene_(—) 42828 for_polymerase_1_g_5 499_Human_papillomavirus_type_6b_g_1 42829 499_Human_papillomavirus_type_6b_g_2 42830 499_Human_papillomavirus_type_6b_g_3 42831 499_Human_papillomavirus_type_6b_g_4 42832 499_Human_papillomavirus_type_6b_g_5 42833 500_Human_papillomavirus_type_6b_g_1 42834 500_Human_papillomavirus_type_6b_g_2 42835 500_Human_papillomavirus_type_6b_g_3 42836 500_Human_papillomavirus_type_6b_g_4 42837 500_Human_papillomavirus_type_6b_g_5 42838 501_Human_papillomavirus_type_6b_g_1 42839 501_Human_papillomavirus_type_6b_g_2 42840 501_Human_papillomavirus_type_6b_g_3 42841 501_Human_papillomavirus_type_6b_g_4 42842 501_Human_papillomavirus_type_6b_g_5 42843 502_Human_papillomavirus_type_6b_g_1 42844 502_Human_papillomavirus_type_6b_g_2 42845 502_Human_papillomavirus_type_6b_g_3 42846 502_Human_papillomavirus_type_6b_g_4 42847 502_Human_papillomavirus_type_6b_g_5 42848 503_Human_papillomavirus_type_6b_g_1 42849 503_Human_papillomavirus_type_6b_g_2 42850 503_Human_papillomavirus_type_6b_g_3 42851 503_Human_papillomavirus_type_6b_g_4 42852 503_Human_papillomavirus_type_6b_g_5 42853 504_Human_papillomavirus_type_6b_g_1 42854 504_Human_papillomavirus_type_6b_g_2 42855 504_Human_papillomavirus_type_6b_g_3 42856 504_Human_papillomavirus_type_6b_g_4 42857 504_Human_papillomavirus_type_6b_g_5 42858 505_Human_papillomavirus_type_6b_g_1 42859 505_Human_papillomavirus_type_6b_g_2 42860 505_Human_papillomavirus_type_6b_g_3 42861 505_Human_papillomavirus_type_6b_g_4 42862 505_Human_papillomavirus_type_6b_g_5 42863 506_Human_papillomavirus_type_6b_g_1 42864 506_Human_papillomavirus_type_6b_g_2 42865 506_Human_papillomavirus_type_6b_g_3 42866 506_Human_papillomavirus_type_6b_g_4 42867 506_Human_papillomavirus_type_6b_g_5 42868 507_Human_papillomavirus_type_6b_g_1 42869 507_Human_papillomavirus_type_6b_g_2 42870 507_Human_papillomavirus_type_6b_g_3 42871 507_Human_papillomavirus_type_6b_g_4 42872 507_Human_papillomavirus_type_6b_g_5 42873 508_Human_papillomavirus_type_6b_g_1 42874 508_Human_papillomavirus_type_6b_g_2 42875 508_Human_papillomavirus_type_6b_g_3 42876 508_Human_papillomavirus_type_6b_g_4 42877 508_Human_papillomavirus_type_6b_g_5 42878 509_Human_papillomavirus_type_6b_g_1 42879 509_Human_papillomavirus_type_6b_g_2 42880 509_Human_papillomavirus_type_6b_g_3 42881 509_Human_papillomavirus_type_6b_g_4 42882 509_Human_papillomavirus_type_6b_g_5 42883 510_Human_papillomavirus_type_6b_g_1 42884 510_Human_papillomavirus_type_6b_g_2 42885 510_Human_papillomavirus_type_6b_g_3 42886 510_Human_papillomavirus_type_6b_g_4 42887 510_Human_papillomavirus_type_6b_g_5 42888 511_Human_papillomavirus_type_6b_g_1 42889 511_Human_papillomavirus_type_6b_g_2 42890 511_Human_papillomavirus_type_6b_g_3 42891 511_Human_papillomavirus_type_6b_g_4 42892 511_Human_papillomavirus_type_6b_g_5 42893 512_Human_papillomavirus_type_6b_g_1 42894 512_Human_papillomavirus_type_6b_g_2 42895 512_Human_papillomavirus_type_6b_g_3 42896 512_Human_papillomavirus_type_6b_g_4 42897 512_Human_papillomavirus_type_6b_g_5 42898 513_Human_papillomavirus_type_6b_g_1 42899 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585_Hepatitis_E_virus_g_1 43244 585_Hepatitis_E_virus_g_2 43245 585_Hepatitis_E_virus_g_3 43246 585_Hepatitis_E_virus_g_4 43247 585_Hepatitis_E_virus_g_5 43248 586_Hepatitis_E_virus_g_1 43249 586_Hepatitis_E_virus_g_2 43250 586_Hepatitis_E_virus_g_3 43251 587_Hepatitis_E_virus_g_1 43252 587_Hepatitis_E_virus_g_2 43253 587_Hepatitis_E_virus_g_3 43254 587_Hepatitis_E_virus_g_4 43255 587_Hepatitis_E_virus_g_5 43256 588_Hepatitis_E_virus_g_1 43257 588_Hepatitis_E_virus_g_2 43258 588_Hepatitis_E_virus_g_3 43259 588_Hepatitis_E_virus_g_4 43260 588_Hepatitis_E_virus_g_5 43261 589_Hepatitis_E_virus_g_1 43262 589_Hepatitis_E_virus_g_2 43263 589_Hepatitis_E_virus_g_3 43264 589_Hepatitis_E_virus_g_4 43265 589_Hepatitis_E_virus_g_5 43266 590_Hepatitis_E_virus_g_1 43267 590_Hepatitis_E_virus_g_2 43268 590_Hepatitis_E_virus_g_3 43269 590_Hepatitis_E_virus_g_4 43270 590_Hepatitis_E_virus_g_5 43271 591_Hepatitis_E_virus_g_1 43272 591_Hepatitis_E_virus_g_2 43273 592_Hepatitis_E_virus_g_1 43274 592_Hepatitis_E_virus_g_2 43275 592_Hepatitis_E_virus_g_3 43276 592_Hepatitis_E_virus_g_4 43277 592_Hepatitis_E_virus_g_5 43278 593_Hepatitis_E_virus_g_1 43279 593_Hepatitis_E_virus_g_2 43280 593_Hepatitis_E_virus_g_3 43281 593_Hepatitis_E_virus_g_4 43282 593_Hepatitis_E_virus_g_5 43283 594_Hepatitis_E_virus_g_1 43284 594_Hepatitis_E_virus_g_2 43285 594_Hepatitis_E_virus_g_3 43286 594_Hepatitis_E_virus_g_4 43287 594_Hepatitis_E_virus_g_5 43288 595_Hepatitis_E_virus_g_1 43289 595_Hepatitis_E_virus_g_2 43290 595_Hepatitis_E_virus_g_3 43291 595_Hepatitis_E_virus_g_4 43292 595_Hepatitis_E_virus_g_5 43293 596_Hepatitis_E_virus_g_1 43294 596_Hepatitis_E_virus_g_2 43295 596_Hepatitis_E_virus_g_3 43296 596_Hepatitis_E_virus_g_4 43297 596_Hepatitis_E_virus_g_5 43298 597_Hepatitis_E_virus_g_1 43299 597_Hepatitis_E_virus_g_2 43300 597_Hepatitis_E_virus_g_3 43301 597_Hepatitis_E_virus_g_4 43302 597_Hepatitis_E_virus_g_5 43303 598_Hepatitis_E_virus_g_1 43304 598_Hepatitis_E_virus_g_2 43305 598_Hepatitis_E_virus_g_3 43306 598_Hepatitis_E_virus_g_4 43307 598_Hepatitis_E_virus_g_5 43308 599_Hepatitis_E_virus_g_1 43309 599_Hepatitis_E_virus_g_2 43310 599_Hepatitis_E_virus_g_3 43311 599_Hepatitis_E_virus_g_4 43312 599_Hepatitis_E_virus_g_5 43313 600_Hepatitis_E_virus_g_1 43314 600_Hepatitis_E_virus_g_2 43315 601_Hepatitis_E_virus_g_1 43316 601_Hepatitis_E_virus_g_2 43317 601_Hepatitis_E_virus_g_3 43318 601_Hepatitis_E_virus_g_4 43319 601_Hepatitis_E_virus_g_5 43320 602_Hepatitis_E_virus_g_1 43321 602_Hepatitis_E_virus_g_2 43322 602_Hepatitis_E_virus_g_3 43323 602_Hepatitis_E_virus_g_4 43324 602_Hepatitis_E_virus_g_5 43325 603_Hepatitis_E_virus_g_1 43326 603_Hepatitis_E_virus_g_2 43327 603_Hepatitis_E_virus_g_3 43328 603_Hepatitis_E_virus_g_4 43329 603_Hepatitis_E_virus_g_5 43330 604_Human_herpesvirus_3_g_1 43331 604_Human_herpesvirus_3_g_2 43332 604_Human_herpesvirus_3_g_3 43333 604_Human_herpesvirus_3_g_4 43334 604_Human_herpesvirus_3_g_5 43335 605_Human_herpesvirus_3_g_1 43336 605_Human_herpesvirus_3_g_2 43337 605_Human_herpesvirus_3_g_3 43338 605_Human_herpesvirus_3_g_4 43339 605_Human_herpesvirus_3_g_5 43340 606_Human_herpesvirus_3_g_1 43341 606_Human_herpesvirus_3_g_2 43342 606_Human_herpesvirus_3_g_3 43343 606_Human_herpesvirus_3_g_4 43344 606_Human_herpesvirus_3_g_5 43345 607_Human_herpesvirus_3_g_1 43346 607_Human_herpesvirus_3_g_2 43347 607_Human_herpesvirus_3_g_3 43348 607_Human_herpesvirus_3_g_4 43349 607_Human_herpesvirus_3_g_5 43350 608_Human_herpesvirus_3_g_1 43351 608_Human_herpesvirus_3_g_2 43352 608_Human_herpesvirus_3_g_3 43353 608_Human_herpesvirus_3_g_4 43354 608_Human_herpesvirus_3_g_5 43355 609_Human_herpesvirus_3_g_1 43356 609_Human_herpesvirus_3_g_2 43357 609_Human_herpesvirus_3_g_3 43358 609_Human_herpesvirus_3_g_4 43359 609_Human_herpesvirus_3_g_5 43360 610_Human_herpesvirus_3_g_1 43361 610_Human_herpesvirus_3_g_2 43362 610_Human_herpesvirus_3_g_3 43363 610_Human_herpesvirus_3_g_4 43364 610_Human_herpesvirus_3_g_5 43365 611_Human_herpesvirus_3_g_1 43366 611_Human_herpesvirus_3_g_2 43367 611_Human_herpesvirus_3_g_3 43368 611_Human_herpesvirus_3_g_4 43369 611_Human_herpesvirus_3_g_5 43370 612_Human_herpesvirus_3_g_1 43371 612_Human_herpesvirus_3_g_2 43372 612_Human_herpesvirus_3_g_3 43373 612_Human_herpesvirus_3_g_4 43374 612_Human_herpesvirus_3_g_5 43375 613_Human_herpesvirus_3_g_1 43376 613_Human_herpesvirus_3_g_2 43377 613_Human_herpesvirus_3_g_3 43378 613_Human_herpesvirus_3_g_4 43379 613_Human_herpesvirus_3_g_5 43380 614_Human_herpesvirus_3_g_1 43381 614_Human_herpesvirus_3_g_2 43382 614_Human_herpesvirus_3_g_3 43383 614_Human_herpesvirus_3_g_4 43384 614_Human_herpesvirus_3_g_5 43385 615_Human_herpesvirus_3_g_1 43386 615_Human_herpesvirus_3_g_2 43387 615_Human_herpesvirus_3_g_3 43388 615_Human_herpesvirus_3_g_4 43389 615_Human_herpesvirus_3_g_5 43390 616_Human_herpesvirus_3_g_1 43391 616_Human_herpesvirus_3_g_2 43392 616_Human_herpesvirus_3_g_3 43393 616_Human_herpesvirus_3_g_4 43394 616_Human_herpesvirus_3_g_5 43395 617_Human_herpesvirus_3_g_1 43396 617_Human_herpesvirus_3_g_2 43397 617_Human_herpesvirus_3_g_3 43398 617_Human_herpesvirus_3_g_4 43399 617_Human_herpesvirus_3_g_5 43400 618_Human_herpesvirus_3_g_1 43401 618_Human_herpesvirus_3_g_2 43402 618_Human_herpesvirus_3_g_3 43403 618_Human_herpesvirus_3_g_4 43404 618_Human_herpesvirus_3_g_5 43405 619_Human_herpesvirus_3_g_1 43406 619_Human_herpesvirus_3_g_2 43407 619_Human_herpesvirus_3_g_3 43408 619_Human_herpesvirus_3_g_4 43409 619_Human_herpesvirus_3_g_5 43410 620_Human_immunodeficiency_virus_1_g_1 43411 620_Human_immunodeficiency_virus_1_g_2 43412 620_Human_immunodeficiency_virus_1_g_3 43413 620_Human_immunodeficiency_virus_1_g_4 43414 620_Human_immunodeficiency_virus_1_g_5 43415 621_Human_immunodeficiency_virus_1_g_1 43416 621_Human_immunodeficiency_virus_1_g_2 43417 621_Human_immunodeficiency_virus_1_g_3 43418 621_Human_immunodeficiency_virus_1_g_4 43419 621_Human_immunodeficiency_virus_1_g_5 43420 622_Human_immunodeficiency_virus_1_g_1 43421 622_Human_immunodeficiency_virus_1_g_2 43422 622_Human_immunodeficiency_virus_1_g_3 43423 622_Human_immunodeficiency_virus_1_g_4 43424 622_Human_immunodeficiency_virus_1_g_5 43425 623_Human_immunodeficiency_virus_1_g_1 43426 623_Human_immunodeficiency_virus_1_g_2 43427 623_Human_immunodeficiency_virus_1_g_3 43428 623_Human_immunodeficiency_virus_1_g_4 43429 623_Human_immunodeficiency_virus_1_g_5 43430 624_Human_immunodeficiency_virus_1_g_1 43431 624_Human_immunodeficiency_virus_1_g_2 43432 624_Human_immunodeficiency_virus_1_g_3 43433 624_Human_immunodeficiency_virus_1_g_4 43434 624_Human_immunodeficiency_virus_1_g_5 43435 625_Human_immunodeficiency_virus_1_g_1 43436 625_Human_immunodeficiency_virus_1_g_2 43437 625_Human_immunodeficiency_virus_1_g_3 43438 625_Human_immunodeficiency_virus_1_g_4 43439 625_Human_immunodeficiency_virus_1_g_5 43440 626_Human_immunodeficiency_virus_1_g_1 43441 626_Human_immunodeficiency_virus_1_g_2 43442 626_Human_immunodeficiency_virus_1_g_3 43443 626_Human_immunodeficiency_virus_1_g_4 43444 626_Human_immunodeficiency_virus_1_g_5 43445 627_Human_immunodeficiency_virus_1_g_1 43446 627_Human_immunodeficiency_virus_1_g_2 43447 627_Human_immunodeficiency_virus_1_g_3 43448 627_Human_immunodeficiency_virus_1_g_4 43449 627_Human_immunodeficiency_virus_1_g_5 43450 628_Human_immunodeficiency_virus_1_g_1 43451 628_Human_immunodeficiency_virus_1_g_2 43452 628_Human_immunodeficiency_virus_1_g_3 43453 628_Human_immunodeficiency_virus_1_g_4 43454 628_Human_immunodeficiency_virus_1_g_5 43455 629_Human_immunodeficiency_virus_1_g_1 43456 629_Human_immunodeficiency_virus_1_g_2 43457 629_Human_immunodeficiency_virus_1_g_3 43458 629_Human_immunodeficiency_virus_1_g_4 43459 629_Human_immunodeficiency_virus_1_g_5 43460 630_Human_immunodeficiency_virus_1_g_1 43461 630_Human_immunodeficiency_virus_1_g_2 43462 630_Human_immunodeficiency_virus_1_g_3 43463 630_Human_immunodeficiency_virus_1_g_4 43464 630_Human_immunodeficiency_virus_1_g_5 43465 631_Human_immunodeficiency_virus_1_g_1 43466 631_Human_immunodeficiency_virus_1_g_2 43467 631_Human_immunodeficiency_virus_1_g_3 43468 631_Human_immunodeficiency_virus_1_g_4 43469 631_Human_immunodeficiency_virus_1_g_5 43470 632_Human_immunodeficiency_virus_1_g_1 43471 632_Human_immunodeficiency_virus_1_g_2 43472 632_Human_immunodeficiency_virus_1_g_3 43473 632_Human_immunodeficiency_virus_1_g_4 43474 632_Human_immunodeficiency_virus_1_g_5 43475 633_Human_immunodeficiency_virus_1_g_1 43476 633_Human_immunodeficiency_virus_1_g_2 43477 633_Human_immunodeficiency_virus_1_g_3 43478 633_Human_immunodeficiency_virus_1_g_4 43479 633_Human_immunodeficiency_virus_1_g_5 43480 634_Human_immunodeficiency_virus_1_g_1 43481 634_Human_immunodeficiency_virus_1_g_2 43482 634_Human_immunodeficiency_virus_1_g_3 43483 634_Human_immunodeficiency_virus_1_g_4 43484 634_Human_immunodeficiency_virus_1_g_5 43485 635_Human_immunodeficiency_virus_1_g_1 43486 635_Human_immunodeficiency_virus_1_g_2 43487 635_Human_immunodeficiency_virus_1_g_3 43488 635_Human_immunodeficiency_virus_1_g_4 43489 635_Human_immunodeficiency_virus_1_g_5 43490 636_Human_immunodeficiency_virus_1_g_1 43491 636_Human_immunodeficiency_virus_1_g_2 43492 636_Human_immunodeficiency_virus_1_g_3 43493 636_Human_immunodeficiency_virus_1_g_4 43494 636_Human_immunodeficiency_virus_1_g_5 43495 637_Human_immunodeficiency_virus_1_g_1 43496 637_Human_immunodeficiency_virus_1_g_2 43497 637_Human_immunodeficiency_virus_1_g_3 43498 637_Human_immunodeficiency_virus_1_g_4 43499 637_Human_immunodeficiency_virus_1_g_5 43500 638_Human_herpesvirus_2_strain_HG52_g_1 43501 638_Human_herpesvirus_2_strain_HG52_g_2 43502 639_Human_herpesvirus_2_strain_HG52_g_1 43503 639_Human_herpesvirus_2_strain_HG52_g_2 43504 639_Human_herpesvirus_2_strain_HG52_g_3 43505 640_Human_herpesvirus_2_strain_HG52_g_1 43506 640_Human_herpesvirus_2_strain_HG52_g_2 43507 640_Human_herpesvirus_2_strain_HG52_g_3 43508 640_Human_herpesvirus_2_strain_HG52_g_4 43509 640_Human_herpesvirus_2_strain_HG52_g_5 43510 641_Human_herpesvirus_2_strain_HG52_g_1 43511 641_Human_herpesvirus_2_strain_HG52_g_2 43512 641_Human_herpesvirus_2_strain_HG52_g_3 43513 641_Human_herpesvirus_2_strain_HG52_g_4 43514 641_Human_herpesvirus_2_strain_HG52_g_5 43515 642_Human_herpesvirus_2_strain_HG52_g_1 43516 642_Human_herpesvirus_2_strain_HG52_g_2 43517 642_Human_herpesvirus_2_strain_HG52_g_3 43518 642_Human_herpesvirus_2_strain_HG52_g_4 43519 642_Human_herpesvirus_2_strain_HG52_g_5 43520 643_Human_herpesvirus_2_strain_HG52_g_1 43521 643_Human_herpesvirus_2_strain_HG52_g_2 43522 643_Human_herpesvirus_2_strain_HG52_g_3 43523 643_Human_herpesvirus_2_strain_HG52_g_4 43524 643_Human_herpesvirus_2_strain_HG52_g_5 43525 644_Human_herpesvirus_2_strain_HG52_g_1 43526 644_Human_herpesvirus_2_strain_HG52_g_2 43527 644_Human_herpesvirus_2_strain_HG52_g_3 43528 645_Human_herpesvirus_2_strain_HG52_g_1 43529 645_Human_herpesvirus_2_strain_HG52_g_2 43530 645_Human_herpesvirus_2_strain_HG52_g_3 43531 645_Human_herpesvirus_2_strain_HG52_g_4 43532 645_Human_herpesvirus_2_strain_HG52_g_5 43533 646_Human_herpesvirus_2_strain_HG52_g_1 43534 646_Human_herpesvirus_2_strain_HG52_g_2 43535 646_Human_herpesvirus_2_strain_HG52_g_3 43536 647_Human_herpesvirus_2_strain_HG52_g_1 43537 647_Human_herpesvirus_2_strain_HG52_g_2 43538 647_Human_herpesvirus_2_strain_HG52_g_3 43539 648_Human_herpesvirus_2_strain_HG52_g_1 43540 648_Human_herpesvirus_2_strain_HG52_g_2 43541 648_Human_herpesvirus_2_strain_HG52_g_3 43542 648_Human_herpesvirus_2_strain_HG52_g_4 43543 648_Human_herpesvirus_2_strain_HG52_g_5 43544 649_Human_herpesvirus_2_strain_HG52_g_1 43545 649_Human_herpesvirus_2_strain_HG52_g_2 43546 649_Human_herpesvirus_2_strain_HG52_g_3 43547 649_Human_herpesvirus_2_strain_HG52_g_4 43548 650_Human_herpesvirus_2_strain_HG52_g_1 43549 650_Human_herpesvirus_2_strain_HG52_g_2 43550 650_Human_herpesvirus_2_strain_HG52_g_3 43551 650_Human_herpesvirus_2_strain_HG52_g_4 43552 651_Human_herpesvirus_2_strain_HG52_g_1 43553 652_Human_herpesvirus_2_strain_HG52_g_1 43554 652_Human_herpesvirus_2_strain_HG52_g_2 43555 652_Human_herpesvirus_2_strain_HG52_g_3 43556 653_Human_herpesvirus_2_strain_HG52_g_1 43557 653_Human_herpesvirus_2_strain_HG52_g_2 43558 653_Human_herpesvirus_2_strain_HG52_g_3 43559 653_Human_herpesvirus_2_strain_HG52_g_4 43560 653_Human_herpesvirus_2_strain_HG52_g_5 43561 654_Human_herpesvirus_2_strain_HG52_g_1 43562 654_Human_herpesvirus_2_strain_HG52_g_2 43563 654_Human_herpesvirus_2_strain_HG52_g_3 43564 654_Human_herpesvirus_2_strain_HG52_g_4 43565 654_Human_herpesvirus_2_strain_HG52_g_5 43566 655_Human_herpesvirus_2_strain_HG52_g_1 43567 655_Human_herpesvirus_2_strain_HG52_g_2 43568 655_Human_herpesvirus_2_strain_HG52_g_3 43569 656_Human_herpesvirus_2_strain_HG52_g_1 43570 656_Human_herpesvirus_2_strain_HG52_g_2 43571 656_Human_herpesvirus_2_strain_HG52_g_3 43572 656_Human_herpesvirus_2_strain_HG52_g_4 43573 656_Human_herpesvirus_2_strain_HG52_g_5 43574 657_Human_herpesvirus_2_strain_HG52_g_1 43575 657_Human_herpesvirus_2_strain_HG52_g_2 43576 657_Human_herpesvirus_2_strain_HG52_g_3 43577 657_Human_herpesvirus_2_strain_HG52_g_4 43578 657_Human_herpesvirus_2_strain_HG52_g_5 43579 658_Human_herpesvirus_2_strain_HG52_g_1 43580 658_Human_herpesvirus_2_strain_HG52_g_2 43581 658_Human_herpesvirus_2_strain_HG52_g_3 43582 658_Human_herpesvirus_2_strain_HG52_g_4 43583 658_Human_herpesvirus_2_strain_HG52_g_5 43584 659_Human_herpesvirus_2_strain_HG52_g_1 43585 659_Human_herpesvirus_2_strain_HG52_g_2 43586 659_Human_herpesvirus_2_strain_HG52_g_3 43587 659_Human_herpesvirus_2_strain_HG52_g_4 43588 659_Human_herpesvirus_2_strain_HG52_g_5 43589 660_Human_herpesvirus_2_strain_HG52_g_1 43590 660_Human_herpesvirus_2_strain_HG52_g_2 43591 660_Human_herpesvirus_2_strain_HG52_g_3 43592 660_Human_herpesvirus_2_strain_HG52_g_4 43593 661_Human_herpesvirus_2_strain_HG52_g_1 43594 661_Human_herpesvirus_2_strain_HG52_g_2 43595 661_Human_herpesvirus_2_strain_HG52_g_3 43596 662_Human_herpesvirus_2_strain_HG52_g_1 43597 662_Human_herpesvirus_2_strain_HG52_g_2 43598 662_Human_herpesvirus_2_strain_HG52_g_3 43599 662_Human_herpesvirus_2_strain_HG52_g_4 43600 662_Human_herpesvirus_2_strain_HG52_g_5 43601 663_Human_herpesvirus_2_strain_HG52_g_1 43602 663_Human_herpesvirus_2_strain_HG52_g_2 43603 663_Human_herpesvirus_2_strain_HG52_g_3 43604 664_Human_herpesvirus_2_strain_HG52_g_1 43605 665_Human_herpesvirus_2_strain_HG52_g_1 43606 665_Human_herpesvirus_2_strain_HG52_g_2 43607 665_Human_herpesvirus_2_strain_HG52_g_3 43608 665_Human_herpesvirus_2_strain_HG52_g_4 43609 665_Human_herpesvirus_2_strain_HG52_g_5 43610 666_Human_herpesvirus_2_strain_HG52_g_1 43611 666_Human_herpesvirus_2_strain_HG52_g_2 43612 666_Human_herpesvirus_2_strain_HG52_g_3 43613 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673_Human_herpesvirus_2_strain_HG52_g_2 43635 673_Human_herpesvirus_2_strain_HG52_g_3 43636 674_Human_herpesvirus_2_strain_HG52_g_1 43637 674_Human_herpesvirus_2_strain_HG52_g_2 43638 674_Human_herpesvirus_2_strain_HG52_g_3 43639 674_Human_herpesvirus_2_strain_HG52_g_4 43640 674_Human_herpesvirus_2_strain_HG52_g_5 43641 675_Human_herpesvirus_2_strain_HG52_g_1 43642 675_Human_herpesvirus_2_strain_HG52_g_2 43643 676_Human_herpesvirus_2_strain_HG52_g_1 43644 676_Human_herpesvirus_2_strain_HG52_g_2 43645 676_Human_herpesvirus_2_strain_HG52_g_3 43646 676_Human_herpesvirus_2_strain_HG52_g_4 43647 676_Human_herpesvirus_2_strain_HG52_g_5 43648 677_Human_herpesvirus_2_strain_HG52_g_1 43649 677_Human_herpesvirus_2_strain_HG52_g_2 43650 677_Human_herpesvirus_2_strain_HG52_g_3 43651 677_Human_herpesvirus_2_strain_HG52_g_4 43652 677_Human_herpesvirus_2_strain_HG52_g_5 43653 678_Human_herpesvirus_2_strain_HG52_g_1 43654 678_Human_herpesvirus_2_strain_HG52_g_2 43655 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691_Human_herpesvirus_2_strain_HG52_g_5 43698 692_Human_herpesvirus_2_strain_HG52_g_1 43699 692_Human_herpesvirus_2_strain_HG52_g_2 43700 692_Human_herpesvirus_2_strain_HG52_g_3 43701 692_Human_herpesvirus_2_strain_HG52_g_4 43702 692_Human_herpesvirus_2_strain_HG52_g_5 43703 693_Human_herpesvirus_2_strain_HG52_g_1 43704 693_Human_herpesvirus_2_strain_HG52_g_2 43705 693_Human_herpesvirus_2_strain_HG52_g_3 43706 694_Human_herpesvirus_2_strain_HG52_g_1 43707 694_Human_herpesvirus_2_strain_HG52_g_2 43708 694_Human_herpesvirus_2_strain_HG52_g_3 43709 694_Human_herpesvirus_2_strain_HG52_g_4 43710 694_Human_herpesvirus_2_strain_HG52_g_5 43711 695_Human_herpesvirus_2_strain_HG52_g_1 43712 695_Human_herpesvirus_2_strain_HG52_g_2 43713 695_Human_herpesvirus_2_strain_HG52_g_3 43714 695_Human_herpesvirus_2_strain_HG52_g_4 43715 695_Human_herpesvirus_2_strain_HG52_g_5 43716 696_Human_herpesvirus_2_strain_HG52_g_1 43717 696_Human_herpesvirus_2_strain_HG52_g_2 43718 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703_Human_papillomavirus_type_41_g_1 43741 703_Human_papillomavirus_type_41_g_2 43742 703_Human_papillomavirus_type_41_g_3 43743 703_Human_papillomavirus_type_41_g_4 43744 703_Human_papillomavirus_type_41_g_5 43745 704_Human_papillomavirus_type_41_g_1 43746 704_Human_papillomavirus_type_41_g_2 43747 704_Human_papillomavirus_type_41_g_3 43748 704_Human_papillomavirus_type_41_g_4 43749 704_Human_papillomavirus_type_41_g_5 43750 705_Human_papillomavirus_type_41_g_1 43751 705_Human_papillomavirus_type_41_g_2 43752 705_Human_papillomavirus_type_41_g_3 43753 705_Human_papillomavirus_type_41_g_4 43754 705_Human_papillomavirus_type_41_g_5 43755 706_Human_papillomavirus_type_41_g_1 43756 706_Human_papillomavirus_type_41_g_2 43757 706_Human_papillomavirus_type_41_g_3 43758 706_Human_papillomavirus_type_41_g_4 43759 706_Human_papillomavirus_type_41_g_5 43760 707_Human_papillomavirus_type_41_g_1 43761 707_Human_papillomavirus_type_41_g_2 43762 707_Human_papillomavirus_type_41_g_3 43763 707_Human_papillomavirus_type_41_g_4 43764 707_Human_papillomavirus_type_41_g_5 43765 708_Human_papillomavirus_type_41_g_1 43766 708_Human_papillomavirus_type_41_g_2 43767 708_Human_papillomavirus_type_41_g_3 43768 708_Human_papillomavirus_type_41_g_4 43769 708_Human_papillomavirus_type_41_g_5 43770 709_Human_papillomavirus_type_41_g_1 43771 709_Human_papillomavirus_type_41_g_2 43772 709_Human_papillomavirus_type_41_g_3 43773 709_Human_papillomavirus_type_41_g_4 43774 709_Human_papillomavirus_type_41_g_5 43775 710_Human_papillomavirus_type_41_g_1 43776 710_Human_papillomavirus_type_41_g_2 43777 710_Human_papillomavirus_type_41_g_3 43778 710_Human_papillomavirus_type_41_g_4 43779 710_Human_papillomavirus_type_41_g_5 43780 711_Human_papillomavirus_type_41_g_1 43781 711_Human_papillomavirus_type_41_g_2 43782 711_Human_papillomavirus_type_41_g_3 43783 711_Human_papillomavirus_type_41_g_4 43784 711_Human_papillomavirus_type_41_g_5 43785 712_Human_papillomavirus_type_41_g_1 43786 712_Human_papillomavirus_type_41_g_2 43787 712_Human_papillomavirus_type_41_g_3 43788 712_Human_papillomavirus_type_41_g_4 43789 712_Human_papillomavirus_type_41_g_5 43790 713_Human_papillomavirus_type_41_g_1 43791 713_Human_papillomavirus_type_41_g_2 43792 713_Human_papillomavirus_type_41_g_3 43793 713_Human_papillomavirus_type_41_g_4 43794 713_Human_papillomavirus_type_41_g_5 43795 714_Human_papillomavirus_type_41_g_1 43796 714_Human_papillomavirus_type_41_g_2 43797 714_Human_papillomavirus_type_41_g_3 43798 714_Human_papillomavirus_type_41_g_4 43799 714_Human_papillomavirus_type_41_g_5 43800 715_Human_papillomavirus_type_41_g_1 43801 715_Human_papillomavirus_type_41_g_2 43802 715_Human_papillomavirus_type_41_g_3 43803 715_Human_papillomavirus_type_41_g_4 43804 715_Human_papillomavirus_type_41_g_5 43805 716_Human_papillomavirus_type_41_g_1 43806 716_Human_papillomavirus_type_41_g_2 43807 716_Human_papillomavirus_type_41_g_3 43808 716_Human_papillomavirus_type_41_g_4 43809 716_Human_papillomavirus_type_41_g_5 43810 717_Human_papillomavirus_type_41_g_1 43811 717_Human_papillomavirus_type_41_g_2 43812 717_Human_papillomavirus_type_41_g_3 43813 717_Human_papillomavirus_type_41_g_4 43814 717_Human_papillomavirus_type_41_g_5 43815 718_Human_papillomavirus_type_41_g_1 43816 718_Human_papillomavirus_type_41_g_2 43817 718_Human_papillomavirus_type_41_g_3 43818 718_Human_papillomavirus_type_41_g_4 43819 718_Human_papillomavirus_type_41_g_5 43820 719_Human_papillomavirus_type_41_g_1 43821 719_Human_papillomavirus_type_41_g_2 43822 719_Human_papillomavirus_type_41_g_3 43823 719_Human_papillomavirus_type_41_g_4 43824 719_Human_papillomavirus_type_41_g_5 43825 720_Human_papillomavirus_type_41_g_1 43826 720_Human_papillomavirus_type_41_g_2 43827 720_Human_papillomavirus_type_41_g_3 43828 720_Human_papillomavirus_type_41_g_4 43829 720_Human_papillomavirus_type_41_g_5 43830 721_Human_papillomavirus_type_41_g_1 43831 721_Human_papillomavirus_type_41_g_2 43832 721_Human_papillomavirus_type_41_g_3 43833 721_Human_papillomavirus_type_41_g_4 43834 721_Human_papillomavirus_type_41_g_5 43835 722_Human_papillomavirus_type_167_isolate_KC10_g_1 43836 722_Human_papillomavirus_type_167_isolate_KC10_g_2 43837 722_Human_papillomavirus_type_167_isolate_KC10_g_3 43838 722_Human_papillomavirus_type_167_isolate_KC10_g_4 43839 722_Human_papillomavirus_type_167_isolate_KC10_g_5 43840 723_Human_papillomavirus_type_167_isolate_KC10_g_1 43841 723_Human_papillomavirus_type_167_isolate_KC10_g_2 43842 723_Human_papillomavirus_type_167_isolate_KC10_g_3 43843 723_Human_papillomavirus_type_167_isolate_KC10_g_4 43844 723_Human_papillomavirus_type_167_isolate_KC10_g_5 43845 724_Human_papillomavirus_type_167_isolate_KC10_g_1 43846 724_Human_papillomavirus_type_167_isolate_KC10_g_2 43847 724_Human_papillomavirus_type_167_isolate_KC10_g_3 43848 724_Human_papillomavirus_type_167_isolate_KC10_g_4 43849 724_Human_papillomavirus_type_167_isolate_KC10_g_5 43850 725_Human_papillomavirus_type_167_isolate_KC10_g_1 43851 725_Human_papillomavirus_type_167_isolate_KC10_g_2 43852 725_Human_papillomavirus_type_167_isolate_KC10_g_3 43853 725_Human_papillomavirus_type_167_isolate_KC10_g_4 43854 725_Human_papillomavirus_type_167_isolate_KC10_g_5 43855 726_Human_papillomavirus_type_167_isolate_KC10_g_1 43856 726_Human_papillomavirus_type_167_isolate_KC10_g_2 43857 726_Human_papillomavirus_type_167_isolate_KC10_g_3 43858 726_Human_papillomavirus_type_167_isolate_KC10_g_4 43859 726_Human_papillomavirus_type_167_isolate_KC10_g_5 43860 727_Human_papillomavirus_type_167_isolate_KC10_g_1 43861 727_Human_papillomavirus_type_167_isolate_KC10_g_2 43862 727_Human_papillomavirus_type_167_isolate_KC10_g_3 43863 727_Human_papillomavirus_type_167_isolate_KC10_g_4 43864 727_Human_papillomavirus_type_167_isolate_KC10_g_5 43865 728_Human_papillomavirus_type_167_isolate_KC10_g_1 43866 728_Human_papillomavirus_type_167_isolate_KC10_g_2 43867 728_Human_papillomavirus_type_167_isolate_KC10_g_3 43868 728_Human_papillomavirus_type_167_isolate_KC10_g_4 43869 728_Human_papillomavirus_type_167_isolate_KC10_g_5 43870 729_Human_papillomavirus_type_167_isolate_KC10_g_1 43871 729_Human_papillomavirus_type_167_isolate_KC10_g_2 43872 729_Human_papillomavirus_type_167_isolate_KC10_g_3 43873 729_Human_papillomavirus_type_167_isolate_KC10_g_4 43874 729_Human_papillomavirus_type_167_isolate_KC10_g_5 43875 730_Human_papillomavirus_type_187_isolate_ACS447_g_1 43876 730_Human_papillomavirus_type_187_isolate_ACS447_g_2 43877 730_Human_papillomavirus_type_187_isolate_ACS447_g_3 43878 730_Human_papillomavirus_type_187_isolate_ACS447_g_4 43879 730_Human_papillomavirus_type_187_isolate_ACS447_g_5 43880 731_Human_papillomavirus_type_187_isolate_ACS447_g_1 43881 731_Human_papillomavirus_type_187_isolate_ACS447_g_2 43882 731_Human_papillomavirus_type_187_isolate_ACS447_g_3 43883 731_Human_papillomavirus_type_187_isolate_ACS447_g_4 43884 731_Human_papillomavirus_type_187_isolate_ACS447_g_5 43885 732_Human_papillomavirus_type_187_isolate_ACS447_g_1 43886 732_Human_papillomavirus_type_187_isolate_ACS447_g_2 43887 732_Human_papillomavirus_type_187_isolate_ACS447_g_3 43888 732_Human_papillomavirus_type_187_isolate_ACS447_g_4 43889 732_Human_papillomavirus_type_187_isolate_ACS447_g_5 43890 733_Human_papillomavirus_type_187_isolate_ACS447_g_1 43891 733_Human_papillomavirus_type_187_isolate_ACS447_g_2 43892 733_Human_papillomavirus_type_187_isolate_ACS447_g_3 43893 733_Human_papillomavirus_type_187_isolate_ACS447_g_4 43894 733_Human_papillomavirus_type_187_isolate_ACS447_g_5 43895 734_Human_papillomavirus_type_187_isolate_ACS447_g_1 43896 734_Human_papillomavirus_type_187_isolate_ACS447_g_2 43897 734_Human_papillomavirus_type_187_isolate_ACS447_g_3 43898 734_Human_papillomavirus_type_187_isolate_ACS447_g_4 43899 734_Human_papillomavirus_type_187_isolate_ACS447_g_5 43900 735_Human_papillomavirus_type_187_isolate_ACS447_g_1 43901 735_Human_papillomavirus_type_187_isolate_ACS447_g_2 43902 735_Human_papillomavirus_type_187_isolate_ACS447_g_3 43903 735_Human_papillomavirus_type_187_isolate_ACS447_g_4 43904 735_Human_papillomavirus_type_187_isolate_ACS447_g_5 43905 736_Human_papillomavirus_type_187_isolate_ACS447_g_1 43906 736_Human_papillomavirus_type_187_isolate_ACS447_g_2 43907 736_Human_papillomavirus_type_187_isolate_ACS447_g_3 43908 736_Human_papillomavirus_type_187_isolate_ACS447_g_4 43909 736_Human_papillomavirus_type_187_isolate_ACS447_g_5 43910 737_Human_papillomavirus_type_187_isolate_ACS447_g_1 43911 737_Human_papillomavirus_type_187_isolate_ACS447_g_2 43912 738_Human_papillomavirus_type_187_isolate_ACS447_g_1 43913 738_Human_papillomavirus_type_187_isolate_ACS447_g_2 43914 738_Human_papillomavirus_type_187_isolate_ACS447_g_3 43915 738_Human_papillomavirus_type_187_isolate_ACS447_g_4 43916 738_Human_papillomavirus_type_187_isolate_ACS447_g_5 43917 739_Human_papillomavirus_type_187_isolate_ACS447_g_1 43918 739_Human_papillomavirus_type_187_isolate_ACS447_g_2 43919 739_Human_papillomavirus_type_187_isolate_ACS447_g_3 43920 739_Human_papillomavirus_type_187_isolate_ACS447_g_4 43921 739_Human_papillomavirus_type_187_isolate_ACS447_g_5 43922 740_Human_papillomavirus_type_187_isolate_ACS447_g_1 43923 740_Human_papillomavirus_type_187_isolate_ACS447_g_2 43924 740_Human_papillomavirus_type_187_isolate_ACS447_g_3 43925 740_Human_papillomavirus_type_187_isolate_ACS447_g_4 43926 740_Human_papillomavirus_type_187_isolate_ACS447_g_5 43927 741_Human_papillomavirus_type_187_isolate_ACS447_g_1 43928 741_Human_papillomavirus_type_187_isolate_ACS447_g_2 43929 741_Human_papillomavirus_type_187_isolate_ACS447_g_3 43930 741_Human_papillomavirus_type_187_isolate_ACS447_g_4 43931 741_Human_papillomavirus_type_187_isolate_ACS447_g_5 43932 742_Human_papillomavirus_type_187_isolate_ACS447_g_1 43933 742_Human_papillomavirus_type_187_isolate_ACS447_g_2 43934 742_Human_papillomavirus_type_187_isolate_ACS447_g_3 43935 742_Human_papillomavirus_type_187_isolate_ACS447_g_4 43936 742_Human_papillomavirus_type_187_isolate_ACS447_g_5 43937 743_Human_papillomavirus_type_187_isolate_ACS447_g_1 43938 743_Human_papillomavirus_type_187_isolate_ACS447_g_2 43939 743_Human_papillomavirus_type_187_isolate_ACS447_g_3 43940 743_Human_papillomavirus_type_187_isolate_ACS447_g_4 43941 743_Human_papillomavirus_type_187_isolate_ACS447_g_5 43942 744_Human_papillomavirus_type_187_isolate_ACS447_g_1 43943 744_Human_papillomavirus_type_187_isolate_ACS447_g_2 43944 744_Human_papillomavirus_type_187_isolate_ACS447_g_3 43945 744_Human_papillomavirus_type_187_isolate_ACS447_g_4 43946 744_Human_papillomavirus_type_187_isolate_ACS447_g_5 43947 745_Human_papillomavirus_type_187_isolate_ACS447_g_1 43948 745_Human_papillomavirus_type_187_isolate_ACS447_g_2 43949 745_Human_papillomavirus_type_187_isolate_ACS447_g_3 43950 745_Human_papillomavirus_type_187_isolate_ACS447_g_4 43951 745_Human_papillomavirus_type_187_isolate_ACS447_g_5 43952 746_Human_papillomavirus_type_187_isolate_ACS447_g_1 43953 746_Human_papillomavirus_type_187_isolate_ACS447_g_2 43954 746_Human_papillomavirus_type_187_isolate_ACS447_g_3 43955 746_Human_papillomavirus_type_187_isolate_ACS447_g_4 43956 746_Human_papillomavirus_type_187_isolate_ACS447_g_5 43957 747_Human_papillomavirus_type_187_isolate_ACS447_g_1 43958 747_Human_papillomavirus_type_187_isolate_ACS447_g_2 43959 747_Human_papillomavirus_type_187_isolate_ACS447_g_3 43960 747_Human_papillomavirus_type_187_isolate_ACS447_g_4 43961 747_Human_papillomavirus_type_187_isolate_ACS447_g_5 43962 748_Human_papillomavirus_type_187_isolate_ACS447_g_1 43963 748_Human_papillomavirus_type_187_isolate_ACS447_g_2 43964 748_Human_papillomavirus_type_187_isolate_ACS447_g_3 43965 748_Human_papillomavirus_type_187_isolate_ACS447_g_4 43966 748_Human_papillomavirus_type_187_isolate_ACS447_g_5 43967 749_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43968 for_polymerase_2_g_1 749_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43969 for_polymerase_2_g_2 749_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43970 for_polymerase_2_g_3 749_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43971 for_polymerase_2_g_4 749_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43972 for_polymerase_2_g_5 750_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43973 for_polymerase_2_g_1 750_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43974 for_polymerase_2_g_2 750_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43975 for_polymerase_2_g_3 750_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43976 for_polymerase_2_g_4 750_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43977 for_polymerase_2_g_5 751_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43978 for_polymerase_2_g_1 751_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43979 for_polymerase_2_g_2 751_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43980 for_polymerase_2_g_3 751_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43981 for_polymerase_2_g_4 751_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43982 for_polymerase_2_g_5 752_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43983 for_polymerase_2_g_1 752_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43984 for_polymerase_2_g_2 752_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43985 for_polymerase_2_g_3 752_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43986 for_polymerase_2_g_4 752_Influenza_C_virus_(C/Ann_Arbor/1/50)_PB2_gene_(—) 43987 for_polymerase_2_g_5 753_Human_papillomavirus_type_88_g_1 43988 753_Human_papillomavirus_type_88_g_2 43989 753_Human_papillomavirus_type_88_g_3 43990 753_Human_papillomavirus_type_88_g_4 43991 753_Human_papillomavirus_type_88_g_5 43992 754_Human_papillomavirus_type_88_g_1 43993 754_Human_papillomavirus_type_88_g_2 43994 754_Human_papillomavirus_type_88_g_3 43995 754_Human_papillomavirus_type_88_g_4 43996 754_Human_papillomavirus_type_88_g_5 43997 755_Human_papillomavirus_type_88_g_1 43998 755_Human_papillomavirus_type_88_g_2 43999 755_Human_papillomavirus_type_88_g_3 44000 755_Human_papillomavirus_type_88_g_4 44001 755_Human_papillomavirus_type_88_g_5 44002 756_Human_papillomavirus_type_88_g_1 44003 756_Human_papillomavirus_type_88_g_2 44004 756_Human_papillomavirus_type_88_g_3 44005 756_Human_papillomavirus_type_88_g_4 44006 756_Human_papillomavirus_type_88_g_5 44007 757_Human_papillomavirus_type_88_g_1 44008 757_Human_papillomavirus_type_88_g_2 44009 757_Human_papillomavirus_type_88_g_3 44010 757_Human_papillomavirus_type_88_g_4 44011 757_Human_papillomavirus_type_88_g_5 44012 758_Human_papillomavirus_type_88_g_1 44013 758_Human_papillomavirus_type_88_g_2 44014 758_Human_papillomavirus_type_88_g_3 44015 758_Human_papillomavirus_type_88_g_4 44016 758_Human_papillomavirus_type_88_g_5 44017 759_Human_papillomavirus_type_88_g_1 44018 759_Human_papillomavirus_type_88_g_2 44019 759_Human_papillomavirus_type_88_g_3 44020 759_Human_papillomavirus_type_88_g_4 44021 759_Human_papillomavirus_type_88_g_5 44022 760_Human_papillomavirus_type_88_g_1 44023 760_Human_papillomavirus_type_88_g_2 44024 760_Human_papillomavirus_type_88_g_3 44025 760_Human_papillomavirus_type_88_g_4 44026 760_Human_papillomavirus_type_88_g_5 44027 761_Human_papillomavirus_type_88_g_1 44028 761_Human_papillomavirus_type_88_g_2 44029 761_Human_papillomavirus_type_88_g_3 44030 761_Human_papillomavirus_type_88_g_4 44031 761_Human_papillomavirus_type_88_g_5 44032 762_Human_papillomavirus_type_88_g_1 44033 762_Human_papillomavirus_type_88_g_2 44034 762_Human_papillomavirus_type_88_g_3 44035 762_Human_papillomavirus_type_88_g_4 44036 762_Human_papillomavirus_type_88_g_5 44037 763_Human_papillomavirus_type_88_g_1 44038 763_Human_papillomavirus_type_88_g_2 44039 763_Human_papillomavirus_type_88_g_3 44040 763_Human_papillomavirus_type_88_g_4 44041 763_Human_papillomavirus_type_88_g_5 44042 764_Human_papillomavirus_type_88_g_1 44043 764_Human_papillomavirus_type_88_g_2 44044 764_Human_papillomavirus_type_88_g_3 44045 764_Human_papillomavirus_type_88_g_4 44046 764_Human_papillomavirus_type_88_g_5 44047 765_Human_papillomavirus_type_88_g_1 44048 765_Human_papillomavirus_type_88_g_2 44049 765_Human_papillomavirus_type_88_g_3 44050 765_Human_papillomavirus_type_88_g_4 44051 765_Human_papillomavirus_type_88_g_5 44052 766_Human_papillomavirus_type_88_g_1 44053 766_Human_papillomavirus_type_88_g_2 44054 766_Human_papillomavirus_type_88_g_3 44055 766_Human_papillomavirus_type_88_g_4 44056 766_Human_papillomavirus_type_88_g_5 44057 767_Human_papillomavirus_type_88_g_1 44058 767_Human_papillomavirus_type_88_g_2 44059 767_Human_papillomavirus_type_88_g_3 44060 767_Human_papillomavirus_type_88_g_4 44061 767_Human_papillomavirus_type_88_g_5 44062 768_Human_papillomavirus_type_88_g_1 44063 768_Human_papillomavirus_type_88_g_2 44064 768_Human_papillomavirus_type_88_g_3 44065 768_Human_papillomavirus_type_88_g_4 44066 768_Human_papillomavirus_type_88_g_5 44067 769_Human_papillomavirus_type_179_complete_genome_g_1 44068 769_Human_papillomavirus_type_179_complete_genome_g_2 44069 769_Human_papillomavirus_type_179_complete_genome_g_3 44070 769_Human_papillomavirus_type_179_complete_genome_g_4 44071 769_Human_papillomavirus_type_179_complete_genome_g_5 44072 770_Human_papillomavirus_type_179_complete_genome_g_1 44073 770_Human_papillomavirus_type_179_complete_genome_g_2 44074 770_Human_papillomavirus_type_179_complete_genome_g_3 44075 770_Human_papillomavirus_type_179_complete_genome_g_4 44076 770_Human_papillomavirus_type_179_complete_genome_g_5 44077 771_Human_papillomavirus_type_179_complete_genome_g_1 44078 771_Human_papillomavirus_type_179_complete_genome_g_2 44079 771_Human_papillomavirus_type_179_complete_genome_g_3 44080 771_Human_papillomavirus_type_179_complete_genome_g_4 44081 771_Human_papillomavirus_type_179_complete_genome_g_5 44082 772_Human_papillomavirus_type_179_complete_genome_g_1 44083 772_Human_papillomavirus_type_179_complete_genome_g_2 44084 772_Human_papillomavirus_type_179_complete_genome_g_3 44085 772_Human_papillomavirus_type_179_complete_genome_g_4 44086 772_Human_papillomavirus_type_179_complete_genome_g_5 44087 773_Human_papillomavirus_type_179_complete_genome_g_1 44088 773_Human_papillomavirus_type_179_complete_genome_g_2 44089 773_Human_papillomavirus_type_179_complete_genome_g_3 44090 773_Human_papillomavirus_type_179_complete_genome_g_4 44091 773_Human_papillomavirus_type_179_complete_genome_g_5 44092 774_Human_papillomavirus_type_179_complete_genome_g_1 44093 774_Human_papillomavirus_type_179_complete_genome_g_2 44094 774_Human_papillomavirus_type_179_complete_genome_g_3 44095 774_Human_papillomavirus_type_179_complete_genome_g_4 44096 774_Human_papillomavirus_type_179_complete_genome_g_5 44097 775_Human_papillomavirus_type_179_complete_genome_g_1 44098 775_Human_papillomavirus_type_179_complete_genome_g_2 44099 775_Human_papillomavirus_type_179_complete_genome_g_3 44100 775_Human_papillomavirus_type_179_complete_genome_g_4 44101 775_Human_papillomavirus_type_179_complete_genome_g_5 44102 776_Human_papillomavirus_type_179_complete_genome_g_1 44103 776_Human_papillomavirus_type_179_complete_genome_g_2 44104 776_Human_papillomavirus_type_179_complete_genome_g_3 44105 776_Human_papillomavirus_type_179_complete_genome_g_4 44106 776_Human_papillomavirus_type_179_complete_genome_g_5 44107 777_Human_papillomavirus_type_179_complete_genome_g_1 44108 777_Human_papillomavirus_type_179_complete_genome_g_2 44109 777_Human_papillomavirus_type_179_complete_genome_g_3 44110 777_Human_papillomavirus_type_179_complete_genome_g_4 44111 777_Human_papillomavirus_type_179_complete_genome_g_5 44112 778_Human_papillomavirus_type_179_complete_genome_g_1 44113 778_Human_papillomavirus_type_179_complete_genome_g_2 44114 778_Human_papillomavirus_type_179_complete_genome_g_3 44115 778_Human_papillomavirus_type_179_complete_genome_g_4 44116 778_Human_papillomavirus_type_179_complete_genome_g_5 44117 779_Human_papillomavirus_type_179_complete_genome_g_1 44118 779_Human_papillomavirus_type_179_complete_genome_g_2 44119 779_Human_papillomavirus_type_179_complete_genome_g_3 44120 779_Human_papillomavirus_type_179_complete_genome_g_4 44121 779_Human_papillomavirus_type_179_complete_genome_g_5 44122 780_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_1 44123 780_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_2 44124 780_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_3 44125 780_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_4 44126 780_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_5 44127 781_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_1 44128 781_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_2 44129 781_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_3 44130 781_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_4 44131 781_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_5 44132 782_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_1 44133 782_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_2 44134 782_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_3 44135 782_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_4 44136 782_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_7_g_5 44137 783_Human_rhinovirus_3_g_1 44138 783_Human_rhinovirus_3_g_2 44139 783_Human_rhinovirus_3_g_3 44140 784_Human_rhinovirus_3_g_1 44141 784_Human_rhinovirus_3_g_2 44142 784_Human_rhinovirus_3_g_3 44143 784_Human_rhinovirus_3_g_4 44144 784_Human_rhinovirus_3_g_5 44145 785_Human_rhinovirus_3_g_1 44146 785_Human_rhinovirus_3_g_2 44147 785_Human_rhinovirus_3_g_3 44148 785_Human_rhinovirus_3_g_4 44149 785_Human_rhinovirus_3_g_5 44150 786_Human_rhinovirus_3_g_1 44151 786_Human_rhinovirus_3_g_2 44152 786_Human_rhinovirus_3_g_3 44153 786_Human_rhinovirus_3_g_4 44154 786_Human_rhinovirus_3_g_5 44155 787_Human_rhinovirus_3_g_1 44156 787_Human_rhinovirus_3_g_2 44157 787_Human_rhinovirus_3_g_3 44158 787_Human_rhinovirus_3_g_4 44159 787_Human_rhinovirus_3_g_5 44160 788_Human_rhinovirus_3_g_1 44161 788_Human_rhinovirus_3_g_2 44162 788_Human_rhinovirus_3_g_3 44163 788_Human_rhinovirus_3_g_4 44164 788_Human_rhinovirus_3_g_5 44165 789_Human_rhinovirus_3_g_1 44166 789_Human_rhinovirus_3_g_2 44167 789_Human_rhinovirus_3_g_3 44168 789_Human_rhinovirus_3_g_4 44169 789_Human_rhinovirus_3_g_5 44170 790_Human_rhinovirus_3_g_1 44171 790_Human_rhinovirus_3_g_2 44172 790_Human_rhinovirus_3_g_3 44173 790_Human_rhinovirus_3_g_4 44174 790_Human_rhinovirus_3_g_5 44175 791_Human_rhinovirus_3_g_1 44176 791_Human_rhinovirus_3_g_2 44177 791_Human_rhinovirus_3_g_3 44178 791_Human_rhinovirus_3_g_4 44179 791_Human_rhinovirus_3_g_5 44180 792_Human_rhinovirus_3_g_1 44181 792_Human_rhinovirus_3_g_2 44182 792_Human_rhinovirus_3_g_3 44183 792_Human_rhinovirus_3_g_4 44184 792_Human_rhinovirus_3_g_5 44185 793_Human_rhinovirus_3_g_1 44186 793_Human_rhinovirus_3_g_2 44187 793_Human_rhinovirus_3_g_3 44188 793_Human_rhinovirus_3_g_4 44189 793_Human_rhinovirus_3_g_5 44190 794_Human_rhinovirus_3_g_1 44191 794_Human_rhinovirus_3_g_2 44192 794_Human_rhinovirus_3_g_3 44193 794_Human_rhinovirus_3_g_4 44194 794_Human_rhinovirus_3_g_5 44195 795_Human_rhinovirus_3_g_1 44196 795_Human_rhinovirus_3_g_2 44197 795_Human_rhinovirus_3_g_3 44198 795_Human_rhinovirus_3_g_4 44199 795_Human_rhinovirus_3_g_5 44200 796_Human_rhinovirus_3_g_1 44201 796_Human_rhinovirus_3_g_2 44202 796_Human_rhinovirus_3_g_3 44203 796_Human_rhinovirus_3_g_4 44204 796_Human_rhinovirus_3_g_5 44205 797_Human_rhinovirus_3_g_1 44206 797_Human_rhinovirus_3_g_2 44207 797_Human_rhinovirus_3_g_3 44208 797_Human_rhinovirus_3_g_4 44209 797_Human_rhinovirus_3_g_5 44210 798_Human_rhinovirus_3_g_1 44211 798_Human_rhinovirus_3_g_2 44212 798_Human_rhinovirus_3_g_3 44213 798_Human_rhinovirus_3_g_4 44214 798_Human_rhinovirus_3_g_5 44215 799_Human_rhinovirus_3_g_1 44216 799_Human_rhinovirus_3_g_2 44217 799_Human_rhinovirus_3_g_3 44218 799_Human_rhinovirus_3_g_4 44219 799_Human_rhinovirus_3_g_5 44220 800_Human_rhinovirus_3_g_1 44221 800_Human_rhinovirus_3_g_2 44222 800_Human_rhinovirus_3_g_3 44223 800_Human_rhinovirus_3_g_4 44224 800_Human_rhinovirus_3_g_5 44225 801_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_1 44226 801_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_2 44227 801_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_3 44228 801_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_4 44229 801_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_5 44230 802_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_1 44231 802_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_2 44232 802_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_3 44233 802_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_4 44234 802_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_5 44235 803_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_1 44236 803_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_2 44237 803_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_3 44238 803_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_4 44239 803_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_5 44240 804_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_1 44241 804_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_2 44242 804_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_3 44243 804_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_4 44244 804_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_5 44245 805_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_1 44246 805_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_2 44247 805_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_3 44248 805_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_4 44249 805_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_3_g_5 44250 806_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44251 segment_1_polymerase_PB2_(PB2)_gene_g_1 806_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44252 segment_1_polymerase_PB2_(PB2)_gene_g_2 806_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44253 segment_1_polymerase_PB2_(PB2)_gene_g_3 806_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44254 segment_1_polymerase_PB2_(PB2)_gene_g_4 806_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44255 segment_1_polymerase_PB2_(PB2)_gene_g_5 807_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44256 segment_1_polymerase_PB2_(PB2)_gene_g_1 807_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44257 segment_1_polymerase_PB2_(PB2)_gene_g_2 807_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44258 segment_1_polymerase_PB2_(PB2)_gene_g_3 807_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44259 segment_1_polymerase_PB2_(PB2)_gene_g_4 807_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44260 segment_1_polymerase_PB2_(PB2)_gene_g_5 808_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44261 segment_1_polymerase_PB2_(PB2)_gene_g_1 808_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44262 segment_1_polymerase_PB2_(PB2)_gene_g_2 808_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44263 segment_1_polymerase_PB2_(PB2)_gene_g_3 808_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44264 segment_1_polymerase_PB2_(PB2)_gene_g_4 808_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44265 segment_1_polymerase_PB2_(PB2)_gene_g_5 809_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44266 segment_1_polymerase_PB2_(PB2)_gene_g_1 809_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44267 segment_1_polymerase_PB2_(PB2)_gene_g_2 809_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44268 segment_1_polymerase_PB2_(PB2)_gene_g_3 809_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44269 segment_1_polymerase_PB2_(PB2)_gene_g_4 809_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44270 segment_1_polymerase_PB2_(PB2)_gene_g_5 810_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44271 segment_1_polymerase_PB2_(PB2)_gene_g_1 810_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44272 segment_1_polymerase_PB2_(PB2)_gene_g_2 810_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44273 segment_1_polymerase_PB2_(PB2)_gene_g_3 810_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44274 segment_1_polymerase_PB2_(PB2)_gene_g_4 810_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44275 segment_1_polymerase_PB2_(PB2)_gene_g_5 811_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44276 segment_1_polymerase_PB2_(PB2)_gene_g_1 811_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44277 segment_1_polymerase_PB2_(PB2)_gene_g_2 811_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44278 segment_1_polymerase_PB2_(PB2)_gene_g_3 811_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44279 segment_1_polymerase_PB2_(PB2)_gene_g_4 811_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44280 segment_1_polymerase_PB2_(PB2)_gene_g_5 812_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44281 segment_1_polymerase_PB2_(PB2)_gene_g_1 812_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44282 segment_1_polymerase_PB2_(PB2)_gene_g_2 812_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44283 segment_1_polymerase_PB2_(PB2)_gene_g_3 812_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44284 segment_1_polymerase_PB2_(PB2)_gene_g_4 812_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44285 segment_1_polymerase_PB2_(PB2)_gene_g_5 813_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44286 segment_1_polymerase_PB2_(PB2)_gene_g_1 813_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44287 segment_1_polymerase_PB2_(PB2)_gene_g_2 813_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44288 segment_1_polymerase_PB2_(PB2)_gene_g_3 813_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44289 segment_1_polymerase_PB2_(PB2)_gene_g_4 813_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 44290 segment_1_polymerase_PB2_(PB2)_gene_g_5 814_Human_papillomavirus_116_g_1 44291 814_Human_papillomavirus_116_g_2 44292 814_Human_papillomavirus_116_g_3 44293 814_Human_papillomavirus_116_g_4 44294 814_Human_papillomavirus_116_g_5 44295 815_Human_papillomavirus_116_g_1 44296 815_Human_papillomavirus_116_g_2 44297 815_Human_papillomavirus_116_g_3 44298 815_Human_papillomavirus_116_g_4 44299 815_Human_papillomavirus_116_g_5 44300 816_Human_papillomavirus_116_g_1 44301 816_Human_papillomavirus_116_g_2 44302 816_Human_papillomavirus_116_g_3 44303 816_Human_papillomavirus_116_g_4 44304 816_Human_papillomavirus_116_g_5 44305 817_Human_papillomavirus_116_g_1 44306 817_Human_papillomavirus_116_g_2 44307 817_Human_papillomavirus_116_g_3 44308 817_Human_papillomavirus_116_g_4 44309 817_Human_papillomavirus_116_g_5 44310 818_Human_papillomavirus_116_g_1 44311 818_Human_papillomavirus_116_g_2 44312 818_Human_papillomavirus_116_g_3 44313 818_Human_papillomavirus_116_g_4 44314 818_Human_papillomavirus_116_g_5 44315 819_Human_papillomavirus_116_g_1 44316 819_Human_papillomavirus_116_g_2 44317 819_Human_papillomavirus_116_g_3 44318 819_Human_papillomavirus_116_g_4 44319 819_Human_papillomavirus_116_g_5 44320 820_Human_papillomavirus_116_g_1 44321 820_Human_papillomavirus_116_g_2 44322 820_Human_papillomavirus_116_g_3 44323 820_Human_papillomavirus_116_g_4 44324 820_Human_papillomavirus_116_g_5 44325 821_Human_papillomavirus_116_g_1 44326 821_Human_papillomavirus_116_g_2 44327 821_Human_papillomavirus_116_g_3 44328 821_Human_papillomavirus_116_g_4 44329 821_Human_papillomavirus_116_g_5 44330 822_Human_papillomavirus_116_g_1 44331 822_Human_papillomavirus_116_g_2 44332 822_Human_papillomavirus_116_g_3 44333 822_Human_papillomavirus_116_g_4 44334 822_Human_papillomavirus_116_g_5 44335 823_Human_papillomavirus_116_g_1 44336 823_Human_papillomavirus_116_g_2 44337 823_Human_papillomavirus_116_g_3 44338 823_Human_papillomavirus_116_g_4 44339 823_Human_papillomavirus_116_g_5 44340 824_Hepatitis_C_virus_genotype_6_g_1 44341 824_Hepatitis_C_virus_genotype_6_g_2 44342 824_Hepatitis_C_virus_genotype_6_g_3 44343 824_Hepatitis_C_virus_genotype_6_g_4 44344 825_Hepatitis_C_virus_genotype_6_g_1 44345 825_Hepatitis_C_virus_genotype_6_g_2 44346 825_Hepatitis_C_virus_genotype_6_g_3 44347 825_Hepatitis_C_virus_genotype_6_g_4 44348 825_Hepatitis_C_virus_genotype_6_g_5 44349 826_Hepatitis_C_virus_genotype_6_g_1 44350 826_Hepatitis_C_virus_genotype_6_g_2 44351 826_Hepatitis_C_virus_genotype_6_g_3 44352 826_Hepatitis_C_virus_genotype_6_g_4 44353 826_Hepatitis_C_virus_genotype_6_g_5 44354 827_Hepatitis_C_virus_genotype_6_g_1 44355 827_Hepatitis_C_virus_genotype_6_g_2 44356 827_Hepatitis_C_virus_genotype_6_g_3 44357 827_Hepatitis_C_virus_genotype_6_g_4 44358 828_Hepatitis_C_virus_genotype_6_g_1 44359 828_Hepatitis_C_virus_genotype_6_g_2 44360 828_Hepatitis_C_virus_genotype_6_g_3 44361 828_Hepatitis_C_virus_genotype_6_g_4 44362 828_Hepatitis_C_virus_genotype_6_g_5 44363 829_Hepatitis_C_virus_genotype_6_g_1 44364 829_Hepatitis_C_virus_genotype_6_g_2 44365 829_Hepatitis_C_virus_genotype_6_g_3 44366 829_Hepatitis_C_virus_genotype_6_g_4 44367 829_Hepatitis_C_virus_genotype_6_g_5 44368 830_Hepatitis_C_virus_genotype_6_g_1 44369 830_Hepatitis_C_virus_genotype_6_g_2 44370 830_Hepatitis_C_virus_genotype_6_g_3 44371 830_Hepatitis_C_virus_genotype_6_g_4 44372 830_Hepatitis_C_virus_genotype_6_g_5 44373 831_Hepatitis_C_virus_genotype_6_g_1 44374 831_Hepatitis_C_virus_genotype_6_g_2 44375 831_Hepatitis_C_virus_genotype_6_g_3 44376 831_Hepatitis_C_virus_genotype_6_g_4 44377 831_Hepatitis_C_virus_genotype_6_g_5 44378 832_Hepatitis_C_virus_genotype_6_g_1 44379 832_Hepatitis_C_virus_genotype_6_g_2 44380 832_Hepatitis_C_virus_genotype_6_g_3 44381 832_Hepatitis_C_virus_genotype_6_g_4 44382 832_Hepatitis_C_virus_genotype_6_g_5 44383 833_Hepatitis_C_virus_genotype_6_g_1 44384 833_Hepatitis_C_virus_genotype_6_g_2 44385 833_Hepatitis_C_virus_genotype_6_g_3 44386 833_Hepatitis_C_virus_genotype_6_g_4 44387 833_Hepatitis_C_virus_genotype_6_g_5 44388 834_Hepatitis_C_virus_genotype_6_g_1 44389 834_Hepatitis_C_virus_genotype_6_g_2 44390 834_Hepatitis_C_virus_genotype_6_g_3 44391 834_Hepatitis_C_virus_genotype_6_g_4 44392 834_Hepatitis_C_virus_genotype_6_g_5 44393 835_Hepatitis_C_virus_genotype_6_g_1 44394 835_Hepatitis_C_virus_genotype_6_g_2 44395 835_Hepatitis_C_virus_genotype_6_g_3 44396 835_Hepatitis_C_virus_genotype_6_g_4 44397 835_Hepatitis_C_virus_genotype_6_g_5 44398 836_Hepatitis_C_virus_genotype_6_g_1 44399 836_Hepatitis_C_virus_genotype_6_g_2 44400 836_Hepatitis_C_virus_genotype_6_g_3 44401 836_Hepatitis_C_virus_genotype_6_g_4 44402 836_Hepatitis_C_virus_genotype_6_g_5 44403 837_Hepatitis_C_virus_genotype_6_g_1 44404 837_Hepatitis_C_virus_genotype_6_g_2 44405 837_Hepatitis_C_virus_genotype_6_g_3 44406 837_Hepatitis_C_virus_genotype_6_g_4 44407 837_Hepatitis_C_virus_genotype_6_g_5 44408 838_Hepatitis_C_virus_genotype_6_g_1 44409 838_Hepatitis_C_virus_genotype_6_g_2 44410 838_Hepatitis_C_virus_genotype_6_g_3 44411 838_Hepatitis_C_virus_genotype_6_g_4 44412 838_Hepatitis_C_virus_genotype_6_g_5 44413 839_Hepatitis_C_virus_genotype_6_g_1 44414 839_Hepatitis_C_virus_genotype_6_g_2 44415 839_Hepatitis_C_virus_genotype_6_g_3 44416 839_Hepatitis_C_virus_genotype_6_g_4 44417 839_Hepatitis_C_virus_genotype_6_g_3 44418 840_Hepatitis_C_virus_genotype_6_g_1 44419 840_Hepatitis_C_virus_genotype_6_g_2 44420 840_Hepatitis_C_virus_genotype_6_g_3 44421 840_Hepatitis_C_virus_genotype_6_g_4 44422 841_Hepatitis_C_virus_genotype_6_g_1 44423 841_Hepatitis_C_virus_genotype_6_g_2 44424 841_Hepatitis_C_virus_genotype_6_g_3 44425 841_Hepatitis_C_virus_genotype_6_g_4 44426 841_Hepatitis_C_virus_genotype_6_g_5 44427 842_Hepatitis_C_virus_genotype_6_g_1 44428 842_Hepatitis_C_virus_genotype_6_g_2 44429 842_Hepatitis_C_virus_genotype_6_g_3 44430 842_Hepatitis_C_virus_genotype_6_g_4 44431 842_Hepatitis_C_virus_genotype_6_g_5 44432 843_Hepatitis_C_virus_genotype_6_g_1 44433 843_Hepatitis_C_virus_genotype_6_g_2 44434 843_Hepatitis_C_virus_genotype_6_g_3 44435 843_Hepatitis_C_virus_genotype_6_g_4 44436 843_Hepatitis_C_virus_genotype_6_g_5 44437 844_Hepatitis_C_virus_genotype_6_g_1 44438 844_Hepatitis_C_virus_genotype_6_g_2 44439 844_Hepatitis_C_virus_genotype_6_g_3 44440 844_Hepatitis_C_virus_genotype_6_g_4 44441 844_Hepatitis_C_virus_genotype_6_g_5 44442 845_Hepatitis_C_virus_genotype_6_g_1 44443 845_Hepatitis_C_virus_genotype_6_g_2 44444 845_Hepatitis_C_virus_genotype_6_g_3 44445 845_Hepatitis_C_virus_genotype_6_g_4 44446 846_Hepatitis_C_virus_genotype_6_g_5 44447 846_Hepatitis_C_virus_genotype_6_g_2 44448 846_Hepatitis_C_virus_genotype_6_g_3 44449 846_Hepatitis_C_virus_genotype_6_g_4 44450 846_Hepatitis_C_virus_genotype_6_g_5 44451 847_Hepatitis_C_virus_genotype_6_g_1 44452 847_Hepatitis_C_virus_genotype_6_g_2 44453 847_Hepatitis_C_virus_genotype_6_g_3 44454 847_Hepatitis_C_virus_genotype_6_g_4 44455 847_Hepatitis_C_virus_genotype_6_g_5 44456 848_Hepatitis_C_virus_genotype_6_g_1 44457 848_Hepatitis_C_virus_genotype_6_g_2 44458 848_Hepatitis_C_virus_genotype_6_g_3 44459 848_Hepatitis_C_virus_genotype_6_g_4 44460 849_Hepatitis_C_virus_genotype_6_g_1 44461 849_Hepatitis_C_virus_genotype_6_g_2 44462 849_Hepatitis_C_virus_genotype_6_g_3 44463 849_Hepatitis_C_virus_genotype_6_g_4 44464 849_Hepatitis_C_virus_genotype_6_g_5 44465 850_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_1 44466 850_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_2 44467 850_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_3 44468 850_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_4 44469 850_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_5 44470 851_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_1 44471 851_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_2 44472 851_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_3 44473 851_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_4 44474 851_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_5 44475 852_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_1 44476 852_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_2 44477 852_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_3 44478 852_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_4 44479 852_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_5 44480 853_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_1 44481 853_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_2 44482 853_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_3 44483 853_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_4 44484 853_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_5 44485 854_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_1 44486 854_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_2 44487 854_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_3 44488 854_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_4 44489 854_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_5 44490 855_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_1 44491 855_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_2 44492 855_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_3 44493 855_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_4 44494 855_Influenza_C_virus_(C/Ann_Arbor/1/50)_segment_5_g_5 44495 856_Human_papillomavirus_type_201_isolate_HPV201_g_1 44496 856_Human_papillomavirus_type_201_isolate_HPV201_g_2 44497 856_Human_papillomavirus_type_201_isolate_HPV201_g_3 44498 856_Human_papillomavirus_type_201_isolate_HPV201_g_4 44499 856_Human_papillomavirus_type_201_isolate_HPV201_g_5 44500 857_Human_papillomavirus_type_201_isolate_HPV201_g_1 44501 857_Human_papillomavirus_type_201_isolate_HPV201_g_2 44502 857_Human_papillomavirus_type_201_isolate_HPV201_g_3 44503 857_Human_papillomavirus_type_201_isolate_HPV201_g_4 44504 857_Human_papillomavirus_type_201_isolate_HPV201_g_5 44505 858_Human_papillomavirus_type_201_isolate_HPV201_g_1 44506 858_Human_papillomavirus_type_201_isolate_HPV201_g_2 44507 858_Human_papillomavirus_type_201_isolate_HPV201_g_3 44508 858_Human_papillomavirus_type_201_isolate_HPV201_g_4 44509 858_Human_papillomavirus_type_201_isolate_HPV201_g_5 44510 859_Human_papillomavirus_type_201_isolate_HPV201_g_1 44511 859_Human_papillomavirus_type_201_isolate_HPV201_g_2 44512 859_Human_papillomavirus_type_201_isolate_HPV201_g_3 44513 859_Human_papillomavirus_type_201_isolate_HPV201_g_4 44514 859_Human_papillomavirus_type_201_isolate_HPV201_g_5 44515 860_Human_papillomavirus_type_201_isolate_HPV201_g_1 44516 860_Human_papillomavirus_type_201_isolate_HPV201_g_2 44517 860_Human_papillomavirus_type_201_isolate_HPV201_g_3 44518 860_Human_papillomavirus_type_201_isolate_HPV201_g_4 44519 860_Human_papillomavirus_type_201_isolate_HPV201_g_5 44520 861_Human_papillomavirus_type_201_isolate_HPV201_g_1 44521 861_Human_papillomavirus_type_201_isolate_HPV201_g_2 44522 861_Human_papillomavirus_type_201_isolate_HPV201_g_3 44523 861_Human_papillomavirus_type_201_isolate_HPV201_g_4 44524 861_Human_papillomavirus_type_201_isolate_HPV201_g_5 44525 862_Human_papillomavirus_type_201_isolate_HPV201_g_1 44526 862_Human_papillomavirus_type_201_isolate_HPV201_g_2 44527 862_Human_papillomavirus_type_201_isolate_HPV201_g_3 44528 862_Human_papillomavirus_type_201_isolate_HPV201_g_4 44529 862_Human_papillomavirus_type_201_isolate_HPV201_g_5 44530 863_Human_papillomavirus_type_201_isolate_HPV201_g_1 44531 863_Human_papillomavirus_type_201_isolate_HPV201_g_2 44532 863_Human_papillomavirus_type_201_isolate_HPV201_g_3 44533 863_Human_papillomavirus_type_201_isolate_HPV201_g_4 44534 863_Human_papillomavirus_type_201_isolate_HPV201_g_5 44535 864_Human_papillomavirus_type_201_isolate_HPV201_g_1 44536 864_Human_papillomavirus_type_201_isolate_HPV201_g_2 44537 864_Human_papillomavirus_type_201_isolate_HPV201_g_3 44538 864_Human_papillomavirus_type_201_isolate_HPV201_g_4 44539 864_Human_papillomavirus_type_201_isolate_HPV201_g_5 44540 865_Human_papillomavirus_type_201_isolate_HPV201_g_1 44541 865_Human_papillomavirus_type_201_isolate_HPV201_g_2 44542 865_Human_papillomavirus_type_201_isolate_HPV201_g_3 44543 865_Human_papillomavirus_type_201_isolate_HPV201_g_4 44544 865_Human_papillomavirus_type_201_isolate_HPV201_g_5 44545 866_Human_papillomavirus_type_201_isolate_HPV201_g_1 44546 866_Human_papillomavirus_type_201_isolate_HPV201_g_2 44547 866_Human_papillomavirus_type_201_isolate_HPV201_g_3 44548 866_Human_papillomavirus_type_201_isolate_HPV201_g_4 44549 866_Human_papillomavirus_type_201_isolate_HPV201_g_5 44550 867_Human_papillomavirus_type_201_isolate_HPV201_g_1 44551 867_Human_papillomavirus_type_201_isolate_HPV201_g_2 44552 867_Human_papillomavirus_type_201_isolate_HPV201_g_3 44553 867_Human_papillomavirus_type_201_isolate_HPV201_g_4 44554 867_Human_papillomavirus_type_201_isolate_HPV201_g_5 44555 868_Human_papillomavirus_type_201_isolate_HPV201_g_1 44556 868_Human_papillomavirus_type_201_isolate_HPV201_g_2 44557 868_Human_papillomavirus_type_201_isolate_HPV201_g_3 44558 868_Human_papillomavirus_type_201_isolate_HPV201_g_4 44559 868_Human_papillomavirus_type_201_isolate_HPV201_g_5 44560 869_Human_papillomavirus_type_201_isolate_HPV201_g_1 44561 869_Human_papillomavirus_type_201_isolate_HPV201_g_2 44562 869_Human_papillomavirus_type_201_isolate_HPV201_g_3 44563 869_Human_papillomavirus_type_201_isolate_HPV201_g_4 44564 869_Human_papillomavirus_type_201_isolate_HPV201_g_5 44565 870_Human_papillomavirus_type_201_isolate_HPV201_g_1 44566 870_Human_papillomavirus_type_201_isolate_HPV201_g_2 44567 870_Human_papillomavirus_type_201_isolate_HPV201_g_3 44568 870_Human_papillomavirus_type_201_isolate_HPV201_g_4 44569 870_Human_papillomavirus_type_201_isolate_HPV201_g_5 44570 871_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_1 44571 871_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_2 44572 871_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_3 44573 871_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_4 44574 871_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_5 44575 872_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_1 44576 872_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_2 44577 872_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_3 44578 872_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_4 44579 872_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_7_g_5 44580 873_Human_papillomavirus_type_16_g_1 44581 873_Human_papillomavirus_type_16_j_2 44582 873_Human_papillomavirus_type_16_g_3 44583 873_Human_papillomavirus_type_16_g_4 44584 873_Human_papillomavirus_type_16_g_5 44585 874_Human_papillomavirus_type_16_g_1 44586 874_Human_papillomavirus_type_16_g_2 44587 874_Human_papillomavirus_type_16_g_3 44588 874_Human_papillomavirus_type_16_g_4 44589 874_Human_papillomavirus_type_16_g_5 44590 875_Human_papillomavirus_type_16_g_1 44591 875_Human_papillomavirus_type_16_g_2 44592 875_Human_papillomavirus_type_16_g_3 44593 875_Human_papillomavirus_type_16_g_4 44594 875_Human_papillomavirus_type_16_g_5 44595 876_Human_papillomavirus_type_16_g_1 44596 876_Human_papillomavirus_type_16_g_2 44597 876_Human_papillomavirus_type_16_g_3 44598 876_Human_papillomavirus_type_16_g_4 44599 876_Human_papillomavirus_type_16_g_5 44600 877_Human_papillomavirus_type_16_g_1 44601 877_Human_papillomavirus_type_16_g_2 44602 877_Human_papillomavirus_type_16_g_3 44603 877_Human_papillomavirus_type_16_g_4 44604 877_Human_papillomavirus_type_16_g_5 44605 878_Human_papillomavirus_type_16_g_1 44606 878_Human_papillomavirus_type_16_g_2 44607 878_Human_papillomavirus_type_16_g_3 44608 878_Human_papillomavirus_type_16_g_4 44609 878_Human_papillomavirus_type_16_g_5 44610 879_Human_papillomavirus_type_16_g_1 44611 879_Human_papillomavirus_type_16_g_2 44612 879_Human_papillomavirus_type_16_g_3 44613 879_Human_papillomavirus_type_16_g_4 44614 879_Human_papillomavirus_type_16_g_5 44615 880_Human_papillomavirus_type_16_g_1 44616 880_Human_papillomavirus_type_16_g_2 44617 880_Human_papillomavirus_type_16_g_3 44618 880_Human_papillomavirus_type_16_g_4 44619 880_Human_papillomavirus_type_16_g_5 44620 881_Human_papillomavirus_type_16_g_1 44621 881_Human_papillomavirus_type_16_g_2 44622 881_Human_papillomavirus_type_16_g_3 44623 881_Human_papillomavirus_type_16_g_4 44624 881_Human_papillomavirus_type_16_g_5 44625 882_Human_papillomavirus_type_16_g_1 44626 882_Human_papillomavirus_type_16_g_2 44627 882_Human_papillomavirus_type_16_g_3 44628 882_Human_papillomavirus_type_16_g_4 44629 882_Human_papillomavirus_type_16_g_5 44630 883_Human_papillomavirus_type_16_g_1 44631 883_Human_papillomavirus_type_16_g_2 44632 883_Human_papillomavirus_type_16_g_3 44633 883_Human_papillomavirus_type_16_g_4 44634 883_Human_papillomavirus_type_16_g_5 44635 884_Human_papillomavirus_type_16_g_1 44636 884_Human_papillomavirus_type_16_g_2 44637 884_Human_papillomavirus_type_16_g_3 44638 884_Human_papillomavirus_type_16_g_4 44639 884_Human_papillomavirus_type_16_g_5 44640 885_Human_papillomavirus_type_16_g_1 44641 885_Human_papillomavirus_type_16_g_2 44642 885_Human_papillomavirus_type_16_g_3 44643 885_Human_papillomavirus_type_16_g_4 44644 885_Human_papillomavirus_type_16_g_5 44645 886_Human_papillomavirus_type_16_g_1 44646 886_Human_papillomavirus_type_16_g_2 44647 886_Human_papillomavirus_type_16_g_3 44648 886_Human_papillomavirus_type_16_g_4 44649 886_Human_papillomavirus_type_16_g_5 44650 887_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44651 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 887_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44652 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 887_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44653 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 887_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44654 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 887_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44655 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 888_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44656 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 888_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44657 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 888_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44658 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 888_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44659 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 888_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44660 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 889_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44661 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 889_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44662 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 889_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44663 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 889_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44664 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 889_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44665 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 890_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44666 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 890_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44667 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 890_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44668 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 890_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44669 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 890_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44670 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 891_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44671 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 891_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44672 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 891_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44673 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 891_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44674 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 891_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44675 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 892_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44676 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_1 892_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44677 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_2 892_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44678 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_3 892_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44679 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_4 892_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 44680 3_polymerase_PA_(PA)_and_PA-X_protein_(PA-X)_genes_g_5 893_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44681 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 893_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44682 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 893_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44683 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 893_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44684 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 893_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44685 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 894_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44686 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 894_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44687 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 894_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44688 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 894_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44689 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 894_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44690 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 895_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44691 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 895_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44692 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 895_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44693 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 895_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44694 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 895_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44695 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 896_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44696 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 896_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44697 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 896_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44698 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 896_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44699 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 896_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44700 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 897_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44701 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 897_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44702 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 897_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44703 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 897_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44704 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 897_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44705 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 898_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44706 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 898_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44707 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 898_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44708 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 898_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44709 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 898_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_2_(—) 44710 polymerase_PB1_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 899_Human_papillomavirus_type_63_g_1 44711 899_Human_papillomavirus_type_63_g_2 44712 899_Human_papillomavirus_type_63_g_3 44713 899_Human_papillomavirus_type_63_g_4 44714 899_Human_papillomavirus_type_63_g_5 44715 900_Human_papillomavirus_type_63_g_1 44716 900_Human_papillomavirus_type_63_g_2 44717 900_Human_papillomavirus_type_63_g_3 44718 900_Human_papillomavirus_type_63_g_4 44719 900_Human_papillomavirus_type_63_g_5 44720 901_Human_papillomavirus_type_63_g_1 44721 901_Human_papillomavirus_type_63_g_2 44722 901_Human_papillomavirus_type_63_g_3 44723 901_Human_papillomavirus_type_63_g_4 44724 901_Human_papillomavirus_type_63_g_5 44725 902_Human_papillomavirus_type_63_g_1 44726 902_Human_papillomavirus_type_63_g_2 44727 902_Human_papillomavirus_type_63_g_3 44728 902_Human_papillomavirus_type_63_g_4 44729 902_Human_papillomavirus_type_63_g_5 44730 903_Human_papillomavirus_type_63_g_1 44731 903_Human_papillomavirus_type_63_g_2 44732 903_Human_papillomavirus_type_63_g_3 44733 903_Human_papillomavirus_type_63_g_4 44734 903_Human_papillomavirus_type_63_g_5 44735 904_Human_papillomavirus_type_63_g_1 44736 904_Human_papillomavirus_type_63_g_2 44737 904_Human_papillomavirus_type_63_g_3 44738 904_Human_papillomavirus_type_63_g_4 44739 904_Human_papillomavirus_type_63_g_5 44740 905_Human_papillomavirus_type_63_g_1 44741 905_Human_papillomavirus_type_63_g_2 44742 905_Human_papillomavirus_type_63_g_3 44743 905_Human_papillomavirus_type_63_g_4 44744 905_Human_papillomavirus_type_63_g_5 44745 906_Human_papillomavirus_type_63_g_1 44746 906_Human_papillomavirus_type_63_g_2 44747 906_Human_papillomavirus_type_63_g_3 44748 906_Human_papillomavirus_type_63_g_4 44749 906_Human_papillomavirus_type_63_g_5 44750 907_Human_papillomavirus_type_63_g_1 44751 907_Human_papillomavirus_type_63_g_2 44752 907_Human_papillomavirus_type_63_g_3 44753 907_Human_papillomavirus_type_63_g_4 44754 907_Human_papillomavirus_type_63_g_5 44755 908_Human_papillomavirus_type_63_g_1 44756 908_Human_papillomavirus_type_63_g_2 44757 908_Human_papillomavirus_type_63_g_3 44758 908_Human_papillomavirus_type_63_g_4 44759 908_Human_papillomavirus_type_63_g_5 44760 909_Human_papillomavirus_type_63_g_1 44761 909_Human_papillomavirus_type_63_g_2 44762 909_Human_papillomavirus_type_63_g_3 44763 909_Human_papillomavirus_type_63_g_4 44764 909_Human_papillomavirus_type_63_g_5 44765 910_Human_papillomavirus_type_63_g_1 44766 910_Human_papillomavirus_type_63_g_2 44767 910_Human_papillomavirus_type_63_g_3 44768 910_Human_papillomavirus_type_63_g_4 44769 910_Human_papillomavirus_type_63_g_5 44770 911_Human_papillomavirus_type_63_g_1 44771 911_Human_papillomavirus_type_63_g_2 44772 911_Human_papillomavirus_type_63_g_3 44773 911_Human_papillomavirus_type_63_g_4 44774 911_Human_papillomavirus_type_63_g_5 44775 912_Human_papillomavirus_type_63_g_1 44776 912_Human_papillomavirus_type_63_g_2 44777 912_Human_papillomavirus_type_63_g_3 44778 912_Human_papillomavirus_type_63_g_4 44779 912_Human_papillomavirus_type_63_g_5 44780 913_Human_papillomavirus_type_63_g_1 44781 913_Human_papillomavirus_type_63_g_2 44782 913_Human_papillomavirus_type_63_g_3 44783 913_Human_papillomavirus_type_63_g_4 44784 913_Human_papillomavirus_type_63_g_5 44785 914_Human_papillomavirus_type_63_g_1 44786 914_Human_papillomavirus_type_63_g_2 44787 914_Human_papillomavirus_type_63_g_3 44788 914_Human_papillomavirus_type_63_g_4 44789 914_Human_papillomavirus_type_63_g_5 44790 915_Human_papillomavirus_type_63_g_1 44791 915_Human_papillomavirus_type_63_g_2 44792 915_Human_papillomavirus_type_63_g_3 44793 915_Human_papillomavirus_type_63_g_4 44794 915_Human_papillomavirus_type_63_g_5 44795 916_Human_papillomavirus_type_63_g_1 44796 916_Human_papillomavirus_type_63_g_2 44797 916_Human_papillomavirus_type_63_g_3 44798 916_Human_papillomavirus_type_63_g_4 44799 916_Human_papillomavirus_type_63_g_5 44800 917_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44801 segment_5_nucleocapsid_protein_(NP)_gene_g_1 917_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44802 segment_5_nucleocapsid_protein_(NP)_gene_g_2 917_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44803 segment_5_nucleocapsid_protein_(NP)_gene_g_3 917_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44804 segment_5_nucleocapsid_protein_(NP)_gene_g_4 917_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44805 segment_5_nucleocapsid_protein_(NP)_gene_g_5 918_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44806 segment_5_nucleocapsid_protein_(NP)_gene_g_1 918_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44807 segment_5_nucleocapsid_protein_(NP)_gene_g_2 918_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44808 segment_5_nucleocapsid_protein_(NP)_gene_g_3 918_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44809 segment_5_nucleocapsid_protein_(NP)_gene_g_4 918_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44810 segment_5_nucleocapsid_protein_(NP)_gene_g_5 919_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44811 segment_5_nucleocapsid_protein_(NP)_gene_g_1 919_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44812 segment_5_nucleocapsid_protein_(NP)_gene_g_2 919_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44813 segment_5_nucleocapsid_protein_(NP)_gene_g_3 919_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44814 segment_5_nucleocapsid_protein_(NP)_gene_g_4 919_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44815 segment_5_nucleocapsid_protein_(NP)_gene_g_5 920_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44816 segment_5_nucleocapsid_protein_(NP)_gene_g_1 920_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44817 segment_5_nucleocapsid_protein_(NP)_gene_g_2 920_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44818 segment_5_nucleocapsid_protein_(NP)_gene_g_3 920_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44819 segment_5_nucleocapsid_protein_(NP)_gene_g_4 920_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 44820 segment_5_nucleocapsid_protein_(NP)_gene_g_5 921_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_1 44821 921_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_2 44822 921_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_3 44823 921_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_4 44824 921_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_5 44825 922_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_1 44826 922_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_2 44827 922_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_3 44828 922_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_4 44829 922_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_5 44830 923_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_1 44831 923_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_2 44832 923_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_3 44833 923_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_4 44834 923_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_5 44835 924_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_1 44836 924_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_2 44837 924_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_3 44838 924_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_4 44839 924_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_6_g_5 44840 925_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44841 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 925_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44842 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 925_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44843 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 925_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44844 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 925_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44845 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 926_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44846 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 926_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44847 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 926_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44848 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 926_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44849 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 926_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44850 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 927_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44851 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 927_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44852 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 927_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44853 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 927_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44854 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 927_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44855 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 928_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44856 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 928_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44857 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 928_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44858 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 928_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44859 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 928_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44860 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 929_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44861 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_1 929_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44862 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_2 929_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44863 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_3 929_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44864 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_4 929_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 44865 polymerase_(PB1)_and_PB1-F2_protein_(PB1-F2)_genes_g_5 930_Human_papillomavirus_—_18_g_1 44866 930_Human_papillomavirus_—_18_g_2 44867 930_Human_papillomavirus_—_18_g_3 44868 930_Human_papillomavirus_—_18_g_4 44869 930_Human_papillomavirus_—_18_g_5 44870 931_Human_papillomavirus_—_18_g_1 44871 931_Human_papillomavirus_—_18_g_2 44872 931_Human_papillomavirus_—_18_g_3 44873 931_Human_papillomavirus_—_18_g_4 44874 931_Human_papillomavirus_—_18_g_5 44875 932_Human_papillomavirus_—_18_g_1 44876 932_Human_papillomavirus_—_18_g_2 44877 932_Human_papillomavirus_—_18_g_3 44878 932_Human_papillomavirus_—_18_g_4 44879 932_Human_papillomavirus_—_18_g_5 44880 933_Human_papillomavirus_—_18_g_1 44881 933_Human_papillomavirus_—_18_g_2 44882 933_Human_papillomavirus_—_18_g_3 44883 933_Human_papillomavirus_—_18_g_4 44884 933_Human_papillomavirus_—_18_g_5 44885 934_Human_papillomavirus_—_18_g_1 44886 934_Human_papillomavirus_—_18_g_2 44887 934_Human_papillomavirus_—_18_g_3 44888 934_Human_papillomavirus_—_18_g_4 44889 934_Human_papillomavirus_—_18_g_5 44890 935_Human_papillomavirus_—_18_g_1 44891 935_Human_papillomavirus_—_18_g_2 44892 935_Human_papillomavirus_—_18_g_3 44893 935_Human_papillomavirus_—_18_g_4 44894 935_Human_papillomavirus_—_18_g_5 44895 936_Human_papillomavirus_—_18_g_1 44896 936_Human_papillomavirus_—_18_g_2 44897 936_Human_papillomavirus_—_18_g_3 44898 936_Human_papillomavirus_—_18_g_4 44899 936_Human_papillomavirus_—_18_g_5 44900 937_Human_papillomavirus_—_18_g_1 44901 937_Human_papillomavirus_—_18_g_2 44902 937_Human_papillomavirus_—_18_g_3 44903 937_Human_papillomavirus_—_18_g_4 44904 937_Human_papillomavirus_—_18_g_5 44905 938_Human_papillomavirus_—_18_g_1 44906 938_Human_papillomavirus_—_18_g_2 44907 938_Human_papillomavirus_—_18_g_3 44908 938_Human_papillomavirus_—_18_g_4 44909 938_Human_papillomavirus_—_18_g_5 44910 939_Human_papillomavirus_—_18_g_1 44911 939_Human_papillomavirus_—_18_g_2 44912 939_Human_papillomavirus_—_18_g_3 44913 939_Human_papillomavirus_—_18_g_4 44914 939_Human_papillomavirus_—_18_g_5 44915 940_Human_papillomavirus_—_18_g_1 44916 940_Human_papillomavirus_—_18_g_2 44917 940_Human_papillomavirus_—_18_g_3 44918 940_Human_papillomavirus_—_18_g_4 44919 940_Human_papillomavirus_—_18_g_5 44920 941_Human_papillomavirus_—_18_g_1 44921 941_Human_papillomavirus_—_18_g_2 44922 941_Human_papillomavirus_—_18_g_3 44923 941_Human_papillomavirus_—_18_g_4 44924 941_Human_papillomavirus_—_18_g_5 44925 942_Human_papillomavirus_—_18_g_1 44926 942_Human_papillomavirus_—_18_g_2 44927 942_Human_papillomavirus_—_18_g_3 44928 942_Human_papillomavirus_—_18_g_4 44929 942_Human_papillomavirus_—_18_g_5 44930 943_Human_papillomavirus_—_18_g_1 44931 943_Human_papillomavirus_—_18_g_2 44932 943_Human_papillomavirus_—_18_g_3 44933 943_Human_papillomavirus_—_18_g_4 44934 943_Human_papillomavirus_—_18_g_5 44935 944_Human_papillomavirus_—_18_g_1 44936 944_Human_papillomavirus_—_18_g_2 44937 944_Human_papillomavirus_—_18_g_3 44938 944_Human_papillomavirus_—_18_g_4 44939 944_Human_papillomavirus_—_18_g_5 44940 945_Human_papillomavirus_—_18_g_1 44941 945_Human_papillomavirus_—_18_g_2 44942 945_Human_papillomavirus_—_18_g_3 44943 945_Human_papillomavirus_—_18_g_4 44944 945_Human_papillomavirus_—_18_g_5 44945 946_Human_papillomavirus_—_18_g_1 44946 946_Human_papillomavirus_—_18_g_2 44947 946_Human_papillomavirus_—_18_g_3 44948 946_Human_papillomavirus_—_18_g_4 44949 946_Human_papillomavirus_—_18_g_5 44950 947_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_1 44951 947_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_2 44952 947_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_3 44953 947_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_4 44954 947_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_5 44955 948_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_1 44956 948_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_2 44957 948_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_3 44958 948_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_4 44959 948_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_5 44960 949_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_1 44961 949_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_2 44962 949_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_3 44963 949_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_4 44964 949_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_5 44965 950_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_1 44966 950_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_2 44967 950_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_3 44968 950_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_4 44969 950_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_5 44970 951_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_1 44971 951_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_2 44972 951_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_3 44973 951_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_4 44974 951_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_5 44975 952_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_1 44976 952_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_2 44977 952_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_3 44978 952_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_4 44979 952_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_segment_2_g_5 44980 953_Hepatitis_GB_virus_A_g_1 44981 953_Hepatitis_GB_virus_A_g_2 44982 953_Hepatitis_GB_virus_A_g_3 44983 953_Hepatitis_GB_virus_A_g_4 44984 953_Hepatitis_GB_virus_A_g_5 44985 954_Hepatitis_GB_virus_A_g_1 44986 954_Hepatitis_GB_virus_A_g_2 44987 954_Hepatitis_GB_virus_A_g_3 44988 954_Hepatitis_GB_virus_A_g_4 44989 954_Hepatitis_GB_virus_A_g_5 44990 955_Hepatitis_GB_virus_A_g_1 44991 955_Hepatitis_GB_virus_A_g_2 44992 955_Hepatitis_GB_virus_A_g_3 44993 955_Hepatitis_GB_virus_A_g_4 44994 955_Hepatitis_GB_virus_A_g_5 44995 956_Hepatitis_GB_virus_A_g_1 44996 956_Hepatitis_GB_virus_A_g_2 44997 956_Hepatitis_GB_virus_A_g_3 44998 956_Hepatitis_GB_virus_A_g_4 44999 956_Hepatitis_GB_virus_A_g_5 45000 957_Hepatitis_GB_virus_A_g_1 45001 957_Hepatitis_GB_virus_A_g_2 45002 957_Hepatitis_GB_virus_A_g_3 45003 957_Hepatitis_GB_virus_A_g_4 45004 957_Hepatitis_GB_virus_A_g_5 45005 958_Hepatitis_GB_virus_A_g_1 45006 958_Hepatitis_GB_virus_A_g_2 45007 958_Hepatitis_GB_virus_A_g_3 45008 958_Hepatitis_GB_virus_A_g_4 45009 958_Hepatitis_GB_virus_A_g_5 45010 959_Hepatitis_GB_virus_A_g_1 45011 959_Hepatitis_GB_virus_A_g_2 45012 959_Hepatitis_GB_virus_A_g_3 45013 959_Hepatitis_GB_virus_A_g_4 45014 959_Hepatitis_GB_virus_A_g_5 45015 960_Hepatitis_GB_virus_A_g_1 45016 960_Hepatitis_GB_virus_A_g_2 45017 960_Hepatitis_GB_virus_A_g_3 45018 960_Hepatitis_GB_virus_A_g_4 45019 960_Hepatitis_GB_virus_A_g_5 45020 961_Hepatitis_GB_virus_A_g_1 45021 961_Hepatitis_GB_virus_A_g_2 45022 961_Hepatitis_GB_virus_A_g_3 45023 961_Hepatitis_GB_virus_A_g_4 45024 961_Hepatitis_GB_virus_A_g_5 45025 962_Hepatitis_GB_virus_A_g_1 45026 962_Hepatitis_GB_virus_A_g_2 45027 962_Hepatitis_GB_virus_A_g_3 45028 962_Hepatitis_GB_virus_A_g_4 45029 962_Hepatitis_GB_virus_A_g_5 45030 963_Hepatitis_GB_virus_A_g_1 45031 963_Hepatitis_GB_virus_A_g_2 45032 963_Hepatitis_GB_virus_A_g_3 45033 963_Hepatitis_GB_virus_A_g_4 45034 963_Hepatitis_GB_virus_A_g_5 45035 964_Hepatitis_GB_virus_A_g_1 45036 964_Hepatitis_GB_virus_A_g_2 45037 964_Hepatitis_GB_virus_A_g_3 45038 964_Hepatitis_GB_virus_A_g_4 45039 964_Hepatitis_GB_virus_A_g_5 45040 965_Hepatitis_GB_virus_A_g_1 45041 965_Hepatitis_GB_virus_A_g_2 45042 965_Hepatitis_GB_virus_A_g_3 45043 965_Hepatitis_GB_virus_A_g_4 45044 965_Hepatitis_GB_virus_A_g_5 45045 966_Hepatitis_GB_virus_A_g_1 45046 966_Hepatitis_GB_virus_A_g_2 45047 966_Hepatitis_GB_virus_A_g_3 45048 966_Hepatitis_GB_virus_A_g_4 45049 966_Hepatitis_GB_virus_A_g_5 45050 967_Hepatitis_GB_virus_A_g_1 45051 967_Hepatitis_GB_virus_A_g_2 45052 967_Hepatitis_GB_virus_A_g_3 45053 967_Hepatitis_GB_virus_A_g_4 45054 967_Hepatitis_GB_virus_A_g_5 45055 969_Hepatitis_GB_virus_A_g_1 45056 969_Hepatitis_GB_virus_A_g_2 45057 969_Hepatitis_GB_virus_A_g_3 45058 969_Hepatitis_GB_virus_A_g_4 45059 969_Hepatitis_GB_virus_A_g_5 45060 970_Hepatitis_GB_virus_A_g_1 45061 970_Hepatitis_GB_virus_A_g_2 45062 970_Hepatitis_GB_virus_A_g_3 45063 970_Hepatitis_GB_virus_A_g_4 45064 971_Hepatitis_GB_virus_A_g_1 45065 971_Hepatitis_GB_virus_A_g_2 45066 971_Hepatitis_GB_virus_A_g_3 45067 971_Hepatitis_GB_virus_A_g_4 45068 971_Hepatitis_GB_virus_A_g_5 45069 972_Hepatitis_GB_virus_A_g_1 45070 972_Hepatitis_GB_virus_A_g_2 45071 972_Hepatitis_GB_virus_A_g_3 45072 973_Hepatitis_GB_virus_A_g_1 45073 973_Hepatitis_GB_virus_A_g_2 45074 973_Hepatitis_GB_virus_A_g_3 45075 973_Hepatitis_GB_virus_A_g_4 45076 973_Hepatitis_GB_virus_A_g_5 45077 974_Hepatitis_GB_virus_A_g_1 45078 974_Hepatitis_GB_virus_A_g_2 45079 974_Hepatitis_GB_virus_A_g_3 45080 974_Hepatitis_GB_virus_A_g_4 45081 974_Hepatitis_GB_virus_A_g_5 45082 975_Hepatitis_GB_virus_A_g_1 45083 975_Hepatitis_GB_virus_A_g_2 45084 975_Hepatitis_GB_virus_A_g_3 45085 976_Hepatitis_GB_virus_A_g_1 45086 976_Hepatitis_GB_virus_A_g_2 45087 976_Hepatitis_GB_virus_A_g_3 45088 976_Hepatitis_GB_virus_A_g_4 45089 977_Hepatitis_GB_virus_A_g_1 45090 977_Hepatitis_GB_virus_A_g_2 45091 977_Hepatitis_GB_virus_A_g_3 45092 977_Hepatitis_GB_virus_A_g_4 45093 977_Hepatitis_GB_virus_A_g_5 45094 978_Hepatitis_GB_virus_A_g_1 45095 978_Hepatitis_GB_virus_A_g_2 45096 978_Hepatitis_GB_virus_A_g_3 45097 978_Hepatitis_GB_virus_A_g_4 45098 978_Hepatitis_GB_virus_A_g_5 45099 979_Hepatitis_GB_virus_A_g_1 45100 979_Hepatitis_GB_virus_A_g_2 45101 979_Hepatitis_GB_virus_A_g_3 45102 979_Hepatitis_GB_virus_A_g_4 45103 979_Hepatitis_GB_virus_A_g_5 45104 980_Human_papillomoavirus_type_5_g_1 45105 980_Human_papillomoavirus_type_5_g_2 45106 980_Human_papillomoavirus_type_5_g_3 45107 980_Human_papillomoavirus_type_5_g_4 45108 980_Human_papillomoavirus_type_5_g_5 45109 981_Human_papillomoavirus_type_5_g_1 45110 981_Human_papillomoavirus_type_5_g_2 45111 981_Human_papillomoavirus_type_5_g_3 45112 981_Human_papillomoavirus_type_5_g_4 45113 981_Human_papillomoavirus_type_5_g_5 45114 982_Human_papillomoavirus_type_5_g_1 45115 982_Human_papillomoavirus_type_5_g_2 45116 982_Human_papillomoavirus_type_5_g_3 45117 982_Human_papillomoavirus_type_5_g_4 45118 982_Human_papillomoavirus_type_5_g_5 45119 983_Human_papillomoavirus_type_5_g_1 45120 983_Human_papillomoavirus_type_5_g_2 45121 983_Human_papillomoavirus_type_5_g_3 45122 983_Human_papillomoavirus_type_5_g_4 45123 983_Human_papillomoavirus_type_5_g_5 45124 984_Human_papillomoavirus_type_5_g_1 45125 984_Human_papillomoavirus_type_5_g_2 45126 984_Human_papillomoavirus_type_5_g_3 45127 984_Human_papillomoavirus_type_5_g_4 45128 984_Human_papillomoavirus_type_5_g_5 45129 985_Human_papillomoavirus_type_5_g_1 45130 985_Human_papillomoavirus_type_5_g_2 45131 985_Human_papillomoavirus_type_5_g_3 45132 985_Human_papillomoavirus_type_5_g_4 45133 985_Human_papillomoavirus_type_5_g_5 45134 986_Human_papillomoavirus_type_5_g_1 45135 986_Human_papillomoavirus_type_5_g_2 45136 986_Human_papillomoavirus_type_5_g_3 45137 986_Human_papillomoavirus_type_5_g_4 45138 986_Human_papillomoavirus_type_5_g_5 45139 987_Human_papillomoavirus_type_5_g_1 45140 987_Human_papillomoavirus_type_5_g_2 45141 987_Human_papillomoavirus_type_5_g_3 45142 987_Human_papillomoavirus_type_5_g_4 45143 987_Human_papillomoavirus_type_5_g_5 45144 988_Human_papillomoavirus_type_5_g_1 45145 988_Human_papillomoavirus_type_5_g_2 45146 988_Human_papillomoavirus_type_5_g_3 45147 988_Human_papillomoavirus_type_5_g_4 45148 988_Human_papillomoavirus_type_5_g_5 45149 989_Human_papillomoavirus_type_5_g_1 45150 989_Human_papillomoavirus_type_5_g_2 45151 989_Human_papillomoavirus_type_5_g_3 45152 989_Human_papillomoavirus_type_5_g_4 45153 990_Human_papillomoavirus_type_5_g_1 45154 990_Human_papillomoavirus_type_5_g_2 45155 990_Human_papillomoavirus_type_5_g_3 45156 990_Human_papillomoavirus_type_5_g_4 45157 990_Human_papillomoavirus_type_5_g_5 45158 991_Human_papillomoavirus_type_5_g_1 45159 991_Human_papillomoavirus_type_5_g_2 45160 991_Human_papillomoavirus_type_5_g_3 45161 991_Human_papillomoavirus_type_5_g_4 45162 991_Human_papillomoavirus_type_5_g_5 45163 992_Human_papillomoavirus_type_5_g_1 45164 992_Human_papillomoavirus_type_5_g_2 45165 992_Human_papillomoavirus_type_5_g_3 45166 992_Human_papillomoavirus_type_5_g_4 45167 992_Human_papillomoavirus_type_5_g_5 45168 993_Human_papillomoavirus_type_5_g_1 45169 993_Human_papillomoavirus_type_5_g_2 45170 993_Human_papillomoavirus_type_5_g_3 45171 993_Human_papillomoavirus_type_5_g_4 45172 993_Human_papillomoavirus_type_5_g_5 45173 994_Human_papillomoavirus_type_5_g_1 45174 994_Human_papillomoavirus_type_5_g_2 45175 994_Human_papillomoavirus_type_5_g_3 45176 994_Human_papillomoavirus_type_5_g_4 45177 994_Human_papillomoavirus_type_5_g_5 45178 995_Human_papillomoavirus_type_5_g_1 45179 995_Human_papillomoavirus_type_5_g_2 45180 995_Human_papillomoavirus_type_5_g_3 45181 995_Human_papillomoavirus_type_5_g_4 45182 995_Human_papillomoavirus_type_5_g_5 45183 996_Human_papillomoavirus_type_5_g_1 45184 996_Human_papillomoavirus_type_5_g_2 45185 996_Human_papillomoavirus_type_5_g_3 45186 996_Human_papillomoavirus_type_5_g_4 45187 996_Human_papillomoavirus_type_5_g_5 45188 997_Human_papillomoavirus_type_5_g_1 45189 997_Human_papillomoavirus_type_5_g_2 45190 997_Human_papillomoavirus_type_5_g_3 45191 997_Human_papillomoavirus_type_5_g_4 45192 997_Human_papillomoavirus_type_5_g_5 45193 998_Influenza_A_virus_na_gene_for_neuraminidase_g_1 45194 998_Influenza_A_virus_na_gene_for_neuraminidase_g_2 45195 998_Influenza_A_virus_na_gene_for_neuraminidase_g_3 45196 998_Influenza_A_virus_na_gene_for_neuraminidase_g_4 45197 998_Influenza_A_virus_na_gene_for_neuraminidase_g_5 45198 999_Influenza_A_virus_na_gene_for_neuraminidase_g_1 45199 999_Influenza_A_virus_na_gene_for_neuraminidase_g_2 45200 999_Influenza_A_virus_na_gene_for_neuraminidase_g_3 45201 999_Influenza_A_virus_na_gene_for_neuraminidase_g_4 45202 999_Influenza_A_virus_na_gene_for_neuraminidase_g_5 45203 1000_Influenza_A_virus_na_gene_for_neuraminidase_g_1 45204 1000_Influenza_A_virus_na_gene_for_neuraminidase_g_2 45205 1000_Influenza_A_virus_na_gene_for_neuraminidase_g_3 45206 1000_Influenza_A_virus_na_gene_for_neuraminidase_g_4 45207 1000_Influenza_A_virus_na_gene_for_neuraminidase_g_5 45208 1001_Influenza_A_virus_na_gene_for_neuraminidase_g_1 45209 1001_Influenza_A_virus_na_gene_for_neuraminidase_g_2 45210 1001_Influenza_A_virus_na_gene_for_neuraminidase_g_3 45211 1001_Influenza_A_virus_na_gene_for_neuraminidase_g_4 45212 1001_Influenza_A_virus_na_gene_for_neuraminidase_g_5 45213 1002_Influenza_A_virus_na_gene_for_neuraminidase_g_1 45214 1002_Influenza_A_virus_na_gene_for_neuraminidase_g_2 45215 1002_Influenza_A_virus_na_gene_for_neuraminidase_g_3 45216 1002_Influenza_A_virus_na_gene_for_neuraminidase_g_4 45217 1002_Influenza_A_virus_na_gene_for_neuraminidase_g_5 45218 1003_Influenza_B_virus_(B/Lee/1940)_segment_5_g_1 45219 1003_Influenza_B_virus_(B/Lee/1940)_segment_5_g_2 45220 1003_Influenza_B_virus_(B/Lee/1940)_segment_5_g_3 45221 1003_Influenza_B_virus_(B/Lee/1940)_segment_5_g_4 45222 1003_Influenza_B_virus_(B/Lee/1940)_segment_5_g_5 45223 1004_Influenza_B_virus_(B/Lee/1940)_segment_5_g_1 45224 1004_Influenza_B_virus_(B/Lee/1940)_segment_5_g_2 45225 1004_Influenza_B_virus_(B/Lee/1940)_segment_5_g_3 45226 1004_Influenza_B_virus_(B/Lee/1940)_segment_5_g_4 45227 1004_Influenza_B_virus_(B/Lee/1940)_segment_5_g_5 45228 1005_Influenza_B_virus_(B/Lee/1940)_segment_5_g_1 45229 1005_Influenza_B_virus_(B/Lee/1940)_segment_5_g_2 45230 1005_Influenza_B_virus_(B/Lee/1940)_segment_5_g_3 45231 1005_Influenza_B_virus_(B/Lee/1940)_segment_5_g_4 45232 1005_Influenza_B_virus_(B/Lee/1940)_segment_5_g_5 45233 1006_Human_papillomavirus_type_172_g_1 45234 1006_Human_papillomavirus_type_172_g_2 45235 1006_Human_papillomavirus_type_172_g_3 45236 1006_Human_papillomavirus_type_172_g_4 45237 1006_Human_papillomavirus_type_172_g_5 45238 1007_Human_papillomavirus_type_172_g_1 45239 1007_Human_papillomavirus_type_172_g_2 45240 1007_Human_papillomavirus_type_172_g_3 45241 1007_Human_papillomavirus_type_172_g_4 45242 1007_Human_papillomavirus_type_172_g_5 45243 1008_Human_papillomavirus_type_172_g_1 45244 1008_Human_papillomavirus_type_172_g_2 45245 1008_Human_papillomavirus_type_172_g_3 45246 1008_Human_papillomavirus_type_172_g_4 45247 1008_Human_papillomavirus_type_172_g_5 45248 1009_Human_papillomavirus_type_172_g_1 45249 1009_Human_papillomavirus_type_172_g_2 45250 1009_Human_papillomavirus_type_172_g_3 45251 1009_Human_papillomavirus_type_172_g_4 45252 1009_Human_papillomavirus_type_172_g_5 45253 1010_Human_papillomavirus_type_172_g_1 45254 1010_Human_papillomavirus_type_172_g_2 45255 1010_Human_papillomavirus_type_172_g_3 45256 1010_Human_papillomavirus_type_172_g_4 45257 1010_Human_papillomavirus_type_172_g_5 45258 1011_Human_papillomavirus_type_172_g_1 45259 1011_Human_papillomavirus_type_172_g_2 45260 1011_Human_papillomavirus_type_172_g_3 45261 1011_Human_papillomavirus_type_172_g_4 45262 1011_Human_papillomavirus_type_172_g_5 45263 1012_Human_papillomavirus_type_172_g_1 45264 1012_Human_papillomavirus_type_172_g_2 45265 1012_Human_papillomavirus_type_172_g_3 45266 1012_Human_papillomavirus_type_172_g_4 45267 1012_Human_papillomavirus_type_172_g_5 45268 1013_Human_papillomavirus_type_172_g_1 45269 1013_Human_papillomavirus_type_172_g_2 45270 1013_Human_papillomavirus_type_172_g_3 45271 1013_Human_papillomavirus_type_172_g_4 45272 1013_Human_papillomavirus_type_172_g_5 45273 1014_Human_papillomavirus_type_172_g_1 45274 1014_Human_papillomavirus_type_172_g_2 45275 1014_Human_papillomavirus_type_172_g_3 45276 1014_Human_papillomavirus_type_172_g_4 45277 1014_Human_papillomavirus_type_172_g_5 45278 1015_Human_papillomavirus_type_172_g_1 45279 1015_Human_papillomavirus_type_172_g_2 45280 1015_Human_papillomavirus_type_172_g_3 45281 1015_Human_papillomavirus_type_172_g_4 45282 1015_Human_papillomavirus_type_172_g_5 45283 1016_Human_papillomavirus_type_172_g_1 45284 1016_Human_papillomavirus_type_172_g_2 45285 1016_Human_papillomavirus_type_172_g_3 45286 1016_Human_papillomavirus_type_172_g_4 45287 1016_Human_papillomavirus_type_172_g_5 45288 1017_Human_papillomavirus_type_172_g_1 45289 1017_Human_papillomavirus_type_172_g_2 45290 1017_Human_papillomavirus_type_172_g_3 45291 1017_Human_papillomavirus_type_172_g_4 45292 1017_Human_papillomavirus_type_172_g_5 45293 1018_Human_papillomavirus_type_172_g_1 45294 1018_Human_papillomavirus_type_172_g_2 45295 1018_Human_papillomavirus_type_172_g_3 45296 1018_Human_papillomavirus_type_172_g_4 45297 1018_Human_papillomavirus_type_172_g_5 45298 1019_Human_papillomavirus_type_172_g_1 45299 1019_Human_papillomavirus_type_172_g_2 45300 1019_Human_papillomavirus_type_172_g_3 45301 1019_Human_papillomavirus_type_172_g_4 45302 1019_Human_papillomavirus_type_172_g_5 45303 1020_Human_papillomavirus_type_172_g_1 45304 1020_Human_papillomavirus_type_172_g_2 45305 1020_Human_papillomavirus_type_172_g_3 45306 1020_Human_papillomavirus_type_172_g_4 45307 1020_Human_papillomavirus_type_172_g_5 45308 1021_Human_papillomavirus_type_172_g_1 45309 1021_Human_papillomavirus_type_172_g_2 45310 1021_Human_papillomavirus_type_172_g_3 45311 1021_Human_papillomavirus_type_172_g_4 45312 1021_Human_papillomavirus_type_172_g_5 45313 1022_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_1 45314 1022_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_2 45315 1022_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_3 45316 1022_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_4 45317 1022_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_5 45318 1023_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_1 45319 1023_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_2 45320 1023_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_3 45321 1023_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_4 45322 1023_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_5 45323 1024_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_1 45324 1024_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_2 45325 1024_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_3 45326 1024_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_4 45327 1024_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_5 45328 1025_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_1 45329 1025_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_2 45330 1025_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_3 45331 1025_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_4 45332 1025_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_5 45333 1026_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_1 45334 1026_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_2 45335 1026_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_3 45336 1026_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_4 45337 1026_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_5 45338 1027_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_1 45339 1027_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_2 45340 1027_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_3 45341 1027_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_4 45342 1027_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_5 45343 1028_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_1 45344 1028_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_2 45345 1028_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_3 45346 1028_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_4 45347 1028_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_5 45348 1029_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_1 45349 1029_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_2 45350 1029_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_3 45351 1029_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_4 45352 1029_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_5 45353 1030_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_1 45354 1030_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_2 45355 1030_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_3 45356 1030_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_4 45357 1030_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_2_g_5 45358 1031_Human_papillomavirus_type_50_g_1 45359 1031_Human_papillomavirus_type_50_g_2 45360 1031_Human_papillomavirus_type_50_g_3 45361 1031_Human_papillomavirus_type_50_g_4 45362 1031_Human_papillomavirus_type_50_g_5 45363 1032_Human_papillomavirus_type_50_g_1 45364 1032_Human_papillomavirus_type_50_g_2 45365 1032_Human_papillomavirus_type_50_g_3 45366 1032_Human_papillomavirus_type_50_g_4 45367 1032_Human_papillomavirus_type_50_g_5 45368 1033_Human_papillomavirus_type_50_g_1 45369 1033_Human_papillomavirus_type_50_g_2 45370 1033_Human_papillomavirus_type_50_g_3 45371 1033_Human_papillomavirus_type_50_g_4 45372 1033_Human_papillomavirus_type_50_g_5 45373 1034_Human_papillomavirus_type_50_g_1 45374 1034_Human_papillomavirus_type_50_g_2 45375 1034_Human_papillomavirus_type_50_g_3 45376 1034_Human_papillomavirus_type_50_g_4 45377 1034_Human_papillomavirus_type_50_g_5 45378 1035_Human_papillomavirus_type_50_g_1 45379 1035_Human_papillomavirus_type_50_g_2 45380 1035_Human_papillomavirus_type_50_g_3 45381 1035_Human_papillomavirus_type_50_g_4 45382 1035_Human_papillomavirus_type_50_g_5 45383 1036_Human_papillomavirus_type_50_g_1 45384 1036_Human_papillomavirus_type_50_g_2 45385 1036_Human_papillomavirus_type_50_g_3 45386 1036_Human_papillomavirus_type_50_g_4 45387 1036_Human_papillomavirus_type_50_g_5 45388 1037_Human_papillomavirus_type_50_g_1 45389 1037_Human_papillomavirus_type_50_g_2 45390 1037_Human_papillomavirus_type_50_g_3 45391 1037_Human_papillomavirus_type_50_g_4 45392 1037_Human_papillomavirus_type_50_g_5 45393 1038_Human_papillomavirus_type_50_g_1 45394 1038_Human_papillomavirus_type_50_g_2 45395 1038_Human_papillomavirus_type_50_g_3 45396 1038_Human_papillomavirus_type_50_g_4 45397 1038_Human_papillomavirus_type_50_g_5 45398 1039_Human_papillomavirus_type_50_g_1 45399 1039_Human_papillomavirus_type_50_g_2 45400 1039_Human_papillomavirus_type_50_g_3 45401 1039_Human_papillomavirus_type_50_g_4 45402 1039_Human_papillomavirus_type_50_g_5 45403 1040_Human_papillomavirus_type_50_g_1 45404 1040_Human_papillomavirus_type_50_g_2 45405 1040_Human_papillomavirus_type_50_g_3 45406 1040_Human_papillomavirus_type_50_g_4 45407 1040_Human_papillomavirus_type_50_g_5 45408 1041_Human_papillomavirus_type_50_g_1 45409 1041_Human_papillomavirus_type_50_g_2 45410 1041_Human_papillomavirus_type_50_g_3 45411 1041_Human_papillomavirus_type_50_g_4 45412 1041_Human_papillomavirus_type_50_g_5 45413 1042_Human_papillomavirus_type_50_g_1 45414 1042_Human_papillomavirus_type_50_g_2 45415 1042_Human_papillomavirus_type_50_g_3 45416 1042_Human_papillomavirus_type_50_g_4 45417 1042_Human_papillomavirus_type_50_g_5 45418 1043_Human_papillomavirus_type_109_g_1 45419 1043_Human_papillomavirus_type_109_g_2 45420 1043_Human_papillomavirus_type_109_g_3 45421 1043_Human_papillomavirus_type_109_g_4 45422 1043_Human_papillomavirus_type_109_g_5 45423 1044_Human_papillomavirus_type_109_g_1 45424 1044_Human_papillomavirus_type_109_g_2 45425 1044_Human_papillomavirus_type_109_g_3 45426 1044_Human_papillomavirus_type_109_g_4 45427 1044_Human_papillomavirus_type_109_g_5 45428 1045_Human_papillomavirus_type_109_g_1 45429 1045_Human_papillomavirus_type_109_g_2 45430 1045_Human_papillomavirus_type_109_g_3 45431 1045_Human_papillomavirus_type_109_g_4 45432 1045_Human_papillomavirus_type_109_g_5 45433 1046_Human_papillomavirus_type_109_g_1 45434 1046_Human_papillomavirus_type_109_g_2 45435 1046_Human_papillomavirus_type_109_g_3 45436 1046_Human_papillomavirus_type_109_g_4 45437 1046_Human_papillomavirus_type_109_g_5 45438 1047_Human_papillomavirus_type_109_g_1 45439 1047_Human_papillomavirus_type_109_g_2 45440 1047_Human_papillomavirus_type_109_g_3 45441 1047_Human_papillomavirus_type_109_g_4 45442 1047_Human_papillomavirus_type_109_g_5 45443 1048_Human_papillomavirus_type_109_g_1 45444 1048_Human_papillomavirus_type_109_g_2 45445 1048_Human_papillomavirus_type_109_g_3 45446 1048_Human_papillomavirus_type_109_g_4 45447 1048_Human_papillomavirus_type_109_g_5 45448 1049_Human_papillomavirus_type_109_g_1 45449 1049_Human_papillomavirus_type_109_g_2 45450 1049_Human_papillomavirus_type_109_g_3 45451 1049_Human_papillomavirus_type_109_g_4 45452 1049_Human_papillomavirus_type_109_g_5 45453 1050_Human_papillomavirus_type_109_g_1 45454 1050_Human_papillomavirus_type_109_g_2 45455 1050_Human_papillomavirus_type_109_g_3 45456 1050_Human_papillomavirus_type_109_g_4 45457 1050_Human_papillomavirus_type_109_g_5 45458 1051_Human_papillomavirus_type_109_g_1 45459 1051_Human_papillomavirus_type_109_g_2 45460 1051_Human_papillomavirus_type_109_g_3 45461 1051_Human_papillomavirus_type_109_g_4 45462 1051_Human_papillomavirus_type_109_g_5 45463 1052_Human_papillomavirus_type_109_g_1 45464 1052_Human_papillomavirus_type_109_g_2 45465 1052_Human_papillomavirus_type_109_g_3 45466 1052_Human_papillomavirus_type_109_g_4 45467 1052_Human_papillomavirus_type_109_g_5 45468 1053_Human_papillomavirus_type_109_g_1 45469 1053_Human_papillomavirus_type_109_g_2 45470 1053_Human_papillomavirus_type_109_g_3 45471 1053_Human_papillomavirus_type_109_g_4 45472 1053_Human_papillomavirus_type_109_g_5 45473 1054_Human_papillomavirus_type_121_g_1 45474 1054_Human_papillomavirus_type_121_g_2 45475 1054_Human_papillomavirus_type_121_g_3 45476 1054_Human_papillomavirus_type_121_g_4 45477 1054_Human_papillomavirus_type_121_g_5 45478 1055_Human_papillomavirus_type_121_g_1 45479 1055_Human_papillomavirus_type_121_g_2 45480 1055_Human_papillomavirus_type_121_g_3 45481 1055_Human_papillomavirus_type_121_g_4 45482 1055_Human_papillomavirus_type_121_g_5 45483 1056_Human_papillomavirus_type_121_g_1 45484 1056_Human_papillomavirus_type_121_g_2 45485 1056_Human_papillomavirus_type_121_g_3 45486 1056_Human_papillomavirus_type_121_g_4 45487 1056_Human_papillomavirus_type_121_g_5 45488 1057_Human_papillomavirus_type_121_g_1 45489 1057_Human_papillomavirus_type_121_g_2 45490 1057_Human_papillomavirus_type_121_g_3 45491 1057_Human_papillomavirus_type_121_g_4 45492 1057_Human_papillomavirus_type_121_g_5 45493 1058_Human_papillomavirus_type_121_g_1 45494 1058_Human_papillomavirus_type_121_g_2 45495 1058_Human_papillomavirus_type_121_g_3 45496 1058_Human_papillomavirus_type_121_g_4 45497 1058_Human_papillomavirus_type_121_g_5 45498 1059_Human_papillomavirus_type_121_g_1 45499 1059_Human_papillomavirus_type_121_g_2 45500 1059_Human_papillomavirus_type_121_g_3 45501 1059_Human_papillomavirus_type_121_g_4 45502 1059_Human_papillomavirus_type_121_g_5 45503 1060_Human_papillomavirus_type_121_g_1 45504 1060_Human_papillomavirus_type_121_g_2 45505 1060_Human_papillomavirus_type_121_g_3 45506 1060_Human_papillomavirus_type_121_g_4 45507 1060_Human_papillomavirus_type_121_g_5 45508 1061_Human_papillomavirus_type_121_g_1 45509 1061_Human_papillomavirus_type_121_g_2 45510 1061_Human_papillomavirus_type_121_g_3 45511 1061_Human_papillomavirus_type_121_g_4 45512 1061_Human_papillomavirus_type_121_g_5 45513 1062_Human_papillomavirus_type_121_g_1 45514 1062_Human_papillomavirus_type_121_g_2 45515 1062_Human_papillomavirus_type_121_g_3 45516 1062_Human_papillomavirus_type_121_g_4 45517 1062_Human_papillomavirus_type_121_g_5 45518 1063_Human_papillomavirus_type_121_g_1 45519 1063_Human_papillomavirus_type_121_g_2 45520 1063_Human_papillomavirus_type_121_g_3 45521 1063_Human_papillomavirus_type_121_g_4 45522 1063_Human_papillomavirus_type_121_g_5 45523 1064_Human_papillomavirus_type_121_g_1 45524 1064_Human_papillomavirus_type_121_g_2 45525 1064_Human_papillomavirus_type_121_g_3 45526 1064_Human_papillomavirus_type_121_g_4 45527 1064_Human_papillomavirus_type_121_g_5 45528 1065_Human_papillomavirus_type_121_g_1 45529 1065_Human_papillomavirus_type_121_g_2 45530 1065_Human_papillomavirus_type_121_g_3 45531 1065_Human_papillomavirus_type_121_g_4 45532 1065_Human_papillomavirus_type_121_g_5 45533 1066_Human_papillomavirus_type_121_g_1 45534 1066_Human_papillomavirus_type_121_g_2 45535 1066_Human_papillomavirus_type_121_g_3 45536 1066_Human_papillomavirus_type_121_g_4 45537 1066_Human_papillomavirus_type_121_g_5 45538 1067_Human_papillomavirus_type_121_g_1 45539 1067_Human_papillomavirus_type_121_g_2 45540 1067_Human_papillomavirus_type_121_g_3 45541 1067_Human_papillomavirus_type_121_g_4 45542 1067_Human_papillomavirus_type_121_g_5 45543 1068_Human_papillomavirus_type_121_g_1 45544 1068_Human_papillomavirus_type_121_g_2 45545 1068_Human_papillomavirus_type_121_g_3 45546 1068_Human_papillomavirus_type_121_g_4 45547 1068_Human_papillomavirus_type_121_g_5 45548 1069_Human_papillomavirus_type_121_g_1 45549 1069_Human_papillomavirus_type_121_g_2 45550 1069_Human_papillomavirus_type_121_g_3 45551 1069_Human_papillomavirus_type_121_g_4 45552 1069_Human_papillomavirus_type_121_g_5 45553 1070_Human_herpesvirus_1_strain_17_g_1 45554 1070_Human_herpesvirus_1_strain_17_g_2 45555 1070_Human_herpesvirus_1_strain_17_g_3 45556 1070_Human_herpesvirus_1_strain_17_g_4 45557 1071_Human_herpesvirus_1_strain_17_g_1 45558 1071_Human_herpesvirus_1_strain_17_g_2 45559 1071_Human_herpesvirus_1_strain_17_g_3 45560 1071_Human_herpesvirus_1_strain_17_g_4 45561 1071_Human_herpesvirus_1_strain_17_g_5 45562 1072_Human_herpesvirus_1_strain_17_g_1 45563 1072_Human_herpesvirus_1_strain_17_g_2 45564 1072_Human_herpesvirus_1_strain_17_g_3 45565 1072_Human_herpesvirus_1_strain_17_g_4 45566 1072_Human_herpesvirus_1_strain_17_g_5 45567 1073_Human_herpesvirus_1_strain_17_g_1 45568 1073_Human_herpesvirus_1_strain_17_g_2 45569 1073_Human_herpesvirus_1_strain_17_g_3 45570 1073_Human_herpesvirus_1_strain_17_g_4 45571 1073_Human_herpesvirus_1_strain_17_g_5 45572 1074_Human_herpesvirus_1_strain_17_g_1 45573 1074_Human_herpesvirus_1_strain_17_g_2 45574 1074_Human_herpesvirus_1_strain_17_g_3 45575 1074_Human_herpesvirus_1_strain_17_g_4 45576 1074_Human_herpesvirus_1_strain_17_g_5 45577 1075_Human_herpesvirus_1_strain_17_g_1 45578 1075_Human_herpesvirus_1_strain_17_g_2 45579 1075_Human_herpesvirus_1_strain_17_g_3 45580 1075_Human_herpesvirus_1_strain_17_g_4 45581 1075_Human_herpesvirus_1_strain_17_g_5 45582 1076_Human_herpesvirus_1_strain_17_g_1 45583 1076_Human_herpesvirus_1_strain_17_g_2 45584 1076_Human_herpesvirus_1_strain_17_g_3 45585 1076_Human_herpesvirus_1_strain_17_g_4 45586 1076_Human_herpesvirus_1_strain_17_g_5 45587 1077_Human_herpesvirus_1_strain_17_g_1 45588 1077_Human_herpesvirus_1_strain_17_g_2 45589 1077_Human_herpesvirus_1_strain_17_g_3 45590 1077_Human_herpesvirus_1_strain_17_g_4 45591 1078_Human_herpesvirus_1_strain_17_g_1 45592 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1164_Human_herpesvirus_1_strain_17_g_3 45945 1164_Human_herpesvirus_1_strain_17_g_4 45946 1164_Human_herpesvirus_1_strain_17_g_5 45947 1165_Human_herpesvirus_1_strain_17_g_1 45948 1165_Human_herpesvirus_1_strain_17_g_2 45949 1165_Human_herpesvirus_1_strain_17_g_3 45950 1165_Human_herpesvirus_1_strain_17_g_4 45951 1165_Human_herpesvirus_1_strain_17_g_5 45952 1166_Human_herpesvirus_1_strain_17_g_1 45953 1166_Human_herpesvirus_1_strain_17_g_2 45954 1166_Human_herpesvirus_1_strain_17_g_3 45955 1166_Human_herpesvirus_1_strain_17_g_4 45956 1166_Human_herpesvirus_1_strain_17_g_5 45957 1167_Human_herpesvirus_1_strain_17_g_1 45958 1167_Human_herpesvirus_1_strain_17_g_2 45959 1167_Human_herpesvirus_1_strain_17_g_3 45960 1167_Human_herpesvirus_1_strain_17_g_4 45961 1167_Human_herpesvirus_1_strain_17_g_5 45962 1168_Human_herpesvirus_1_strain_17_g_1 45963 1168_Human_herpesvirus_1_strain_17_g_2 45964 1169_Human_herpesvirus_1_strain_17_g_1 45965 1169_Human_herpesvirus_1_strain_17_g_2 45966 1169_Human_herpesvirus_1_strain_17_g_3 45967 1169_Human_herpesvirus_1_strain_17_g_4 45968 1169_Human_herpesvirus_1_strain_17_g_5 45969 1170_Human_herpesvirus_1_strain_17_g_1 45970 1170_Human_herpesvirus_1_strain_17_g_2 45971 1171_Human_herpesvirus_1_strain_17_g_1 45972 1171_Human_herpesvirus_1_strain_17_g_2 45973 1171_Human_herpesvirus_1_strain_17_g_3 45974 1171_Human_herpesvirus_1_strain_17_g_4 45975 1171_Human_herpesvirus_1_strain_17_g_5 45976 1172_Human_herpesvirus_1_strain_17_g_1 45977 1172_Human_herpesvirus_1_strain_17_g_2 45978 1172_Human_herpesvirus_1_strain_17_g_3 45979 1172_Human_herpesvirus_1_strain_17_g_4 45980 1172_Human_herpesvirus_1_strain_17_g_5 45981 1173_Human_herpesvirus_1_strain_17_g_1 45982 1173_Human_herpesvirus_1_strain_17_g_2 45983 1173_Human_herpesvirus_1_strain_17_g_3 45984 1173_Human_herpesvirus_1_strain_17_g_4 45985 1173_Human_herpesvirus_1_strain_17_g_5 45986 1174_Human_herpesvirus_1_strain_17_g_1 45987 1174_Human_herpesvirus_1_strain_17_g_2 45988 1174_Human_herpesvirus_1_strain_17_g_3 45989 1174_Human_herpesvirus_1_strain_17_g_4 45990 1174_Human_herpesvirus_1_strain_17_g_5 45991 1175_Human_herpesvirus_1_strain_17_g_1 45992 1175_Human_herpesvirus_1_strain_17_g_2 45993 1175_Human_herpesvirus_1_strain_17_g_3 45994 1175_Human_herpesvirus_1_strain_17_g_4 45995 1175_Human_herpesvirus_1_strain_17_g_5 45996 1176_Human_herpesvirus_1_strain_17_g_1 45997 1176_Human_herpesvirus_1_strain_17_g_2 45998 1176_Human_herpesvirus_1_strain_17_g_3 45999 1176_Human_herpesvirus_1_strain_17_g_4 46000 1176_Human_herpesvirus_1_strain_17_g_5 46001 1177_Human_herpesvirus_1_strain_17_g_1 46002 1177_Human_herpesvirus_1_strain_17_g_2 46003 1177_Human_herpesvirus_1_strain_17_g_3 46004 1177_Human_herpesvirus_1_strain_17_g_4 46005 1177_Human_herpesvirus_1_strain_17_g_5 46006 1178_Human_herpesvirus_1_strain_17_g_1 46007 1178_Human_herpesvirus_1_strain_17_g_2 46008 1178_Human_herpesvirus_1_strain_17_g_3 46009 1178_Human_herpesvirus_1_strain_17_g_4 46010 1178_Human_herpesvirus_1_strain_17_g_5 46011 1179_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46012 neuraminidase_(NA)_gene_g_1 1179_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46013 neuraminidase_(NA)_gene_g_2 1179_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46014 neuraminidase_(NA)_gene_g_3 1179_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46015 neuraminidase_(NA)_gene_g_4 1179_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46016 neuraminidase_(NA)_gene_g_5 1180_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46017 neuraminidase_(NA)_gene_g_1 1180_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46018 neuraminidase_(NA)_gene_g_2 1180_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46019 neuraminidase_(NA)_gene_g_3 1180_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46020 neuraminidase_(NA)_gene_g_4 1180_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46021 neuraminidase_(NA)_gene_g_5 1181_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46022 neuraminidase_(NA)_gene_g_1 1181_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46023 neuraminidase_(NA)_gene_g_2 1181_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46024 neuraminidase_(NA)_gene_g_3 1181_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46025 neuraminidase_(NA)_gene_g_4 1181_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46026 neuraminidase_(NA)_gene_g_5 1182_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46027 neuraminidase_(NA)_gene_g_1 1182_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46028 neuraminidase_(NA)_gene_g_2 1182_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46029 neuraminidase_(NA)_gene_g_3 1182_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46030 neuraminidase_(NA)_gene_g_4 1182_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 46031 neuraminidase_(NA)_gene_g_5 1183_Hepatitis_B_virus_(strain_ayw)_genome_g_1 46032 1183_Hepatitis_B_virus_(strain_ayw)_genome_g_2 46033 1183_Hepatitis_B_virus_(strain_ayw)_genome_g_3 46034 1183_Hepatitis_B_virus_(strain_ayw)_genome_g_4 46035 1183_Hepatitis_B_virus_(strain_ayw)_genome_g_5 46036 1184_Hepatitis_B_virus_(strain_ayw)_genome_g_1 46037 1184_Hepatitis_B_virus_(strain_ayw)_genome_g_2 46038 1184_Hepatitis_B_virus_(strain_ayw)_genome_g_3 46039 1184_Hepatitis_B_virus_(strain_ayw)_genome_g_4 46040 1184_Hepatitis_B_virus_(strain_ayw)_genome_g_5 46041 1185_Hepatitis_B_virus_(strain_ayw)_genome_g_1 46042 1185_Hepatitis_B_virus_(strain_ayw)_genome_g_2 46043 1185_Hepatitis_B_virus_(strain_ayw)_genome_g_3 46044 1185_Hepatitis_B_virus_(strain_ayw)_genome_g_4 46045 1185_Hepatitis_B_virus_(strain_ayw)_genome_g_5 46046 1186_Hepatitis_B_virus_(strain_ayw)_genome_g_1 46047 1186_Hepatitis_B_virus_(strain_ayw)_genome_g_2 46048 1186_Hepatitis_B_virus_(strain_ayw)_genome_g_3 46049 1186_Hepatitis_B_virus_(strain_ayw)_genome_g_4 46050 1186_Hepatitis_B_virus_(strain_ayw)_genome_g_5 46051 1187_Hepatitis_B_virus_(strain_ayw)_genome_g_1 46052 1187_Hepatitis_B_virus_(strain_ayw)_genome_g_2 46053 1187_Hepatitis_B_virus_(strain_ayw)_genome_g_3 46054 1187_Hepatitis_B_virus_(strain_ayw)_genome_g_4 46055 1187_Hepatitis_B_virus_(strain_ayw)_genome_g_5 46056 1188_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_3 46059 1188_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_4 46060 1188_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_5 46061 1189_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_1 46062 1189_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_2 46063 1189_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_3 46064 1189_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_4 46065 1189_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_5 46066 1190_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_1 46067 1190_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_2 46068 1190_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_3 46069 1190_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_4 46070 1190_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_5 46071 1191_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_1 46072 1191_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_2 46073 1191_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_3 46074 1191_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_4 46075 1191_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_5 46076 1192_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_1 46077 1192_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_2 46078 1192_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_3 46079 1192_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_4 46080 1192_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_5 46081 1193_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_1 46082 1193_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_2 46083 1193_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_3 46084 1193_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_4 46085 1193_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_5 46086 1194_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_1 46087 1194_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_2 46088 1194_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_3 46089 1194_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_4 46090 1194_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_5 46091 1195_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_1 46092 1195_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_2 46093 1195_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_3 46094 1195_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_4 46095 1195_Influenza_A_virus_(A/New_York/392/2004(H3N2))_segment_1_g_5 46096 1196_Human_papillomavirus_type_178_g_1 46097 1196_Human_papillomavirus_type_178_g_2 46098 1196_Human_papillomavirus_type_178_g_3 46099 1196_Human_papillomavirus_type_178_g_4 46100 1196_Human_papillomavirus_type_178_g_5 46101 1197_Human_papillomavirus_type_178_g_1 46102 1197_Human_papillomavirus_type_178_g_2 46103 1197_Human_papillomavirus_type_178_g_3 46104 1197_Human_papillomavirus_type_178_g_4 46105 1197_Human_papillomavirus_type_178_g_5 46106 1198_Human_papillomavirus_type_178_g_1 46107 1198_Human_papillomavirus_type_178_g_2 46108 1198_Human_papillomavirus_type_178_g_3 46109 1198_Human_papillomavirus_type_178_g_4 46110 1198_Human_papillomavirus_type_178_g_5 46111 1199_Human_papillomavirus_type_178_g_1 46112 1199_Human_papillomavirus_type_178_g_2 46113 1199_Human_papillomavirus_type_178_g_3 46114 1199_Human_papillomavirus_type_178_g_4 46115 1199_Human_papillomavirus_type_178_g_5 46116 1200_Human_papillomavirus_type_178_g_1 46117 1200_Human_papillomavirus_type_178_g_2 46118 1200_Human_papillomavirus_type_178_g_3 46119 1200_Human_papillomavirus_type_178_g_4 46120 1200_Human_papillomavirus_type_178_g_5 46121 1201_Human_papillomavirus_type_178_g_1 46122 1201_Human_papillomavirus_type_178_g_2 46123 1201_Human_papillomavirus_type_178_g_3 46124 1201_Human_papillomavirus_type_178_g_4 46125 1201_Human_papillomavirus_type_178_g_5 46126 1202_Human_papillomavirus_type_178_g_1 46127 1202_Human_papillomavirus_type_178_g_2 46128 1202_Human_papillomavirus_type_178_g_3 46129 1202_Human_papillomavirus_type_178_g_4 46130 1202_Human_papillomavirus_type_178_g_5 46131 1203_Human_papillomavirus_type_178_g_1 46132 1203_Human_papillomavirus_type_178_g_2 46133 1203_Human_papillomavirus_type_178_g_3 46134 1203_Human_papillomavirus_type_178_g_4 46135 1203_Human_papillomavirus_type_178_g_5 46136 1204_Human_papillomavirus_type_178_g_1 46137 1204_Human_papillomavirus_type_178_g_2 46138 1204_Human_papillomavirus_type_178_g_3 46139 1204_Human_papillomavirus_type_178_g_4 46140 1204_Human_papillomavirus_type_178_g_5 46141 1205_Human_papillomavirus_type_178_g_1 46142 1205_Human_papillomavirus_type_178_g_2 46143 1205_Human_papillomavirus_type_178_g_3 46144 1205_Human_papillomavirus_type_178_g_4 46145 1205_Human_papillomavirus_type_178_g_5 46146 1206_Human_papillomavirus_type_178_g_1 46147 1206_Human_papillomavirus_type_178_g_2 46148 1206_Human_papillomavirus_type_178_g_3 46149 1206_Human_papillomavirus_type_178_g_4 46150 1206_Human_papillomavirus_type_178_g_5 46151 1207_Human_papillomavirus_type_178_g_1 46152 1207_Human_papillomavirus_type_178_g_2 46153 1207_Human_papillomavirus_type_178_g_3 46154 1207_Human_papillomavirus_type_178_g_4 46155 1207_Human_papillomavirus_type_178_g_5 46156 1208_Human_papillomavirus_type_178_g_1 46157 1208_Human_papillomavirus_type_178_g_2 46158 1208_Human_papillomavirus_type_178_g_3 46159 1208_Human_papillomavirus_type_178_g_4 46160 1208_Human_papillomavirus_type_178_g_5 46161 1209_Human_papillomavirus_type_178_g_1 46162 1209_Human_papillomavirus_type_178_g_2 46163 1209_Human_papillomavirus_type_178_g_3 46164 1209_Human_papillomavirus_type_178_g_4 46165 1209_Human_papillomavirus_type_178_g_5 46166 1210_Human_papillomavirus_type_178_g_1 46167 1210_Human_papillomavirus_type_178_g_2 46168 1210_Human_papillomavirus_type_178_g_3 46169 1210_Human_papillomavirus_type_178_g_4 46170 1210_Human_papillomavirus_type_178_g_5 46171 1211_Human_papillomavirus_type_178_g_1 46172 1211_Human_papillomavirus_type_178_g_2 46173 1211_Human_papillomavirus_type_178_g_3 46174 1211_Human_papillomavirus_type_178_g_4 46175 1211_Human_papillomavirus_type_178_g_5 46176 1212_Human_papillomavirus_type_178_g_1 46177 1212_Human_papillomavirus_type_178_g_2 46178 1212_Human_papillomavirus_type_178_g_3 46179 1212_Human_papillomavirus_type_178_g_4 46180 1212_Human_papillomavirus_type_178_g_5 46181 1213_Human_papillomavirus_type_48_g_1 46182 1213_Human_papillomavirus_type_48_g_2 46183 1213_Human_papillomavirus_type_48_g_3 46184 1213_Human_papillomavirus_type_48_g_4 46185 1213_Human_papillomavirus_type_48_g_5 46186 1214_Human_papillomavirus_type_48_g_1 46187 1214_Human_papillomavirus_type_48_g_2 46188 1214_Human_papillomavirus_type_48_g_3 46189 1214_Human_papillomavirus_type_48_g_4 46190 1214_Human_papillomavirus_type_48_g_5 46191 1215_Human_papillomavirus_type_48_g_1 46192 1215_Human_papillomavirus_type_48_g_2 46193 1215_Human_papillomavirus_type_48_g_3 46194 1215_Human_papillomavirus_type_48_g_4 46195 1215_Human_papillomavirus_type_48_g_5 46196 1216_Human_papillomavirus_type_48_g_1 46197 1216_Human_papillomavirus_type_48_g_2 46198 1216_Human_papillomavirus_type_48_g_3 46199 1216_Human_papillomavirus_type_48_g_4 46200 1216_Human_papillomavirus_type_48_g_5 46201 1217_Human_papillomavirus_type_48_g_1 46202 1217_Human_papillomavirus_type_48_g_2 46203 1217_Human_papillomavirus_type_48_g_3 46204 1217_Human_papillomavirus_type_48_g_4 46205 1217_Human_papillomavirus_type_48_g_5 46206 1218_Human_papillomavirus_type_48_g_1 46207 1218_Human_papillomavirus_type_48_g_2 46208 1218_Human_papillomavirus_type_48_g_3 46209 1218_Human_papillomavirus_type_48_g_4 46210 1218_Human_papillomavirus_type_48_g_5 46211 1219_Human_papillomavirus_type_48_g_1 46212 1219_Human_papillomavirus_type_48_g_2 46213 1219_Human_papillomavirus_type_48_g_3 46214 1219_Human_papillomavirus_type_48_g_4 46215 1219_Human_papillomavirus_type_48_g_5 46216 1220_Human_papillomavirus_type_48_g_1 46217 1220_Human_papillomavirus_type_48_g_2 46218 1220_Human_papillomavirus_type_48_g_3 46219 1220_Human_papillomavirus_type_48_g_4 46220 1220_Human_papillomavirus_type_48_g_5 46221 1221_Human_papillomavirus_type_48_g_1 46222 1221_Human_papillomavirus_type_48_g_2 46223 1221_Human_papillomavirus_type_48_g_3 46224 1221_Human_papillomavirus_type_48_g_4 46225 1221_Human_papillomavirus_type_48_g_5 46226 1222_Human_immunodeficiency_virus_2_g_1 46227 1222_Human_immunodeficiency_virus_2_g_2 46228 1222_Human_immunodeficiency_virus_2_g_3 46229 1222_Human_immunodeficiency_virus_2_g_4 46230 1222_Human_immunodeficiency_virus_2_g_5 46231 1223_Human_immunodeficiency_virus_2_g_1 46232 1223_Human_immunodeficiency_virus_2_g_2 46233 1223_Human_immunodeficiency_virus_2_g_3 46234 1223_Human_immunodeficiency_virus_2_g_4 46235 1223_Human_immunodeficiency_virus_2_g_5 46236 1224_Human_immunodeficiency_virus_2_g_1 46237 1224_Human_immunodeficiency_virus_2_g_2 46238 1224_Human_immunodeficiency_virus_2_g_3 46239 1224_Human_immunodeficiency_virus_2_g_4 46240 1224_Human_immunodeficiency_virus_2_g_5 46241 1225_Human_immunodeficiency_virus_2_g_1 46242 1225_Human_immunodeficiency_virus_2_g_2 46243 1225_Human_immunodeficiency_virus_2_g_3 46244 1225_Human_immunodeficiency_virus_2_g_4 46245 1225_Human_immunodeficiency_virus_2_g_5 46246 1226_Human_immunodeficiency_virus_2_g_1 46247 1226_Human_immunodeficiency_virus_2_g_2 46248 1226_Human_immunodeficiency_virus_2_g_3 46249 1226_Human_immunodeficiency_virus_2_g_4 46250 1226_Human_immunodeficiency_virus_2_g_5 46251 1227_Human_immunodeficiency_virus_2_g_1 46252 1227_Human_immunodeficiency_virus_2_g_2 46253 1227_Human_immunodeficiency_virus_2_g_3 46254 1227_Human_immunodeficiency_virus_2_g_4 46255 1227_Human_immunodeficiency_virus_2_g_5 46256 1228_Human_immunodeficiency_virus_2_g_1 46257 1228_Human_immunodeficiency_virus_2_g_2 46258 1228_Human_immunodeficiency_virus_2_g_3 46259 1228_Human_immunodeficiency_virus_2_g_4 46260 1228_Human_immunodeficiency_virus_2_g_5 46261 1229_Human_immunodeficiency_virus_2_g_1 46262 1229_Human_immunodeficiency_virus_2_g_2 46263 1229_Human_immunodeficiency_virus_2_g_3 46264 1229_Human_immunodeficiency_virus_2_g_4 46265 1229_Human_immunodeficiency_virus_2_g_5 46266 1230_Human_immunodeficiency_virus_2_g_1 46267 1230_Human_immunodeficiency_virus_2_g_2 46268 1230_Human_immunodeficiency_virus_2_g_3 46269 1230_Human_immunodeficiency_virus_2_g_4 46270 1230_Human_immunodeficiency_virus_2_g_5 46271 1231_Human_immunodeficiency_virus_2_g_1 46272 1231_Human_immunodeficiency_virus_2_g_2 46273 1231_Human_immunodeficiency_virus_2_g_3 46274 1231_Human_immunodeficiency_virus_2_g_4 46275 1231_Human_immunodeficiency_virus_2_g_5 46276 1232_Human_immunodeficiency_virus_2_g_1 46277 1232_Human_immunodeficiency_virus_2_g_2 46278 1232_Human_immunodeficiency_virus_2_g_3 46279 1232_Human_immunodeficiency_virus_2_g_4 46280 1232_Human_immunodeficiency_virus_2_g_5 46281 1233_Human_immunodeficiency_virus_2_g_1 46282 1233_Human_immunodeficiency_virus_2_g_2 46283 1233_Human_immunodeficiency_virus_2_g_3 46284 1233_Human_immunodeficiency_virus_2_g_4 46285 1233_Human_immunodeficiency_virus_2_g_5 46286 1234_Human_immunodeficiency_virus_2_g_1 46287 1234_Human_immunodeficiency_virus_2_g_2 46288 1234_Human_immunodeficiency_virus_2_g_3 46289 1234_Human_immunodeficiency_virus_2_g_4 46290 1234_Human_immunodeficiency_virus_2_g_5 46291 1235_Human_immunodeficiency_virus_2_g_1 46292 1235_Human_immunodeficiency_virus_2_g_2 46293 1235_Human_immunodeficiency_virus_2_g_3 46294 1235_Human_immunodeficiency_virus_2_g_4 46295 1235_Human_immunodeficiency_virus_2_g_5 46296 1236_Human_immunodeficiency_virus_2_g_1 46297 1236_Human_immunodeficiency_virus_2_g_2 46298 1236_Human_immunodeficiency_virus_2_g_3 46299 1236_Human_immunodeficiency_virus_2_g_4 46300 1236_Human_immunodeficiency_virus_2_g_5 46301 1237_Human_immunodeficiency_virus_2_g_1 46302 1237_Human_immunodeficiency_virus_2_g_2 46303 1237_Human_immunodeficiency_virus_2_g_3 46304 1237_Human_immunodeficiency_virus_2_g_4 46305 1237_Human_immunodeficiency_virus_2_g_5 46306 1238_Human_immunodeficiency_virus_2_g_1 46307 1238_Human_immunodeficiency_virus_2_g_2 46308 1238_Human_immunodeficiency_virus_2_g_3 46309 1238_Human_immunodeficiency_virus_2_g_4 46310 1238_Human_immunodeficiency_virus_2_g_5 46311 1239_Human_immunodeficiency_virus_2_g_1 46312 1239_Human_immunodeficiency_virus_2_g_2 46313 1239_Human_immunodeficiency_virus_2_g_3 46314 1239_Human_immunodeficiency_virus_2_g_4 46315 1239_Human_immunodeficiency_virus_2_g_5 46316 1240_Human_immunodeficiency_virus_2_g_1 46317 1240_Human_immunodeficiency_virus_2_g_2 46318 1240_Human_immunodeficiency_virus_2_g_3 46319 1240_Human_immunodeficiency_virus_2_g_4 46320 1240_Human_immunodeficiency_virus_2_g_5 46321 1241_Human_immunodeficiency_virus_2_g_1 46322 1241_Human_immunodeficiency_virus_2_g_2 46323 1241_Human_immunodeficiency_virus_2_g_3 46324 1241_Human_immunodeficiency_virus_2_g_4 46325 1241_Human_immunodeficiency_virus_2_g_5 46326 1242_Human_immunodeficiency_virus_2_g_1 46327 1242_Human_immunodeficiency_virus_2_g_2 46328 1242_Human_immunodeficiency_virus_2_g_3 46329 1242_Human_immunodeficiency_virus_2_g_4 46330 1242_Human_immunodeficiency_virus_2_g_5 46331 1243_Human_immunodeficiency_virus_2_g_1 46332 1243_Human_immunodeficiency_virus_2_g_2 46333 1243_Human_immunodeficiency_virus_2_g_3 46334 1243_Human_immunodeficiency_virus_2_g_4 46335 1243_Human_immunodeficiency_virus_2_g_5 46336 1244_Human_immunodeficiency_virus_2_g_1 46337 1244_Human_immunodeficiency_virus_2_g_2 46338 1244_Human_immunodeficiency_virus_2_g_3 46339 1244_Human_immunodeficiency_virus_2_g_4 46340 1244_Human_immunodeficiency_virus_2_g_5 46341 1245_Human_immunodeficiency_virus_2_g_1 46342 1245_Human_immunodeficiency_virus_2_g_2 46343 1245_Human_immunodeficiency_virus_2_g_3 46344 1245_Human_immunodeficiency_virus_2_g_4 46345 1245_Human_immunodeficiency_virus_2_g_5 46346 1246_Human_immunodeficiency_virus_2_g_1 46347 1246_Human_immunodeficiency_virus_2_g_2 46348 1246_Human_immunodeficiency_virus_2_g_3 46349 1246_Human_immunodeficiency_virus_2_g_4 46350 1246_Human_immunodeficiency_virus_2_g_5 46351 1247_Human_immunodeficiency_virus_2_g_1 46352 1247_Human_immunodeficiency_virus_2_g_2 46353 1247_Human_immunodeficiency_virus_2_g_3 46354 1247_Human_immunodeficiency_virus_2_g_4 46355 1247_Human_immunodeficiency_virus_2_g_5 46356 1248_Human_immunodeficiency_virus_2_g_1 46357 1248_Human_immunodeficiency_virus_2_g_2 46358 1248_Human_immunodeficiency_virus_2_g_3 46359 1248_Human_immunodeficiency_virus_2_g_4 46360 1248_Human_immunodeficiency_virus_2_g_5 46361 1249_Human_immunodeficiency_virus_2_g_1 46362 1249_Human_immunodeficiency_virus_2_g_2 46363 1249_Human_immunodeficiency_virus_2_g_3 46364 1249_Human_immunodeficiency_virus_2_g_4 46365 1249_Human_immunodeficiency_virus_2_g_5 46366 1250_Influenza_B_virus_(B/Lee/1940)_segment_4_g_1 46367 1250_Influenza_B_virus_(B/Lee/1940)_segment_4_g_2 46368 1250_Influenza_B_virus_(B/Lee/1940)_segment_4_g_3 46369 1250_Influenza_B_virus_(B/Lee/1940)_segment_4_g_4 46370 1250_Influenza_B_virus_(B/Lee/1940)_segment_4_g_5 46371 1251_Influenza_B_virus_(B/Lee/1940)_segment_4_g_1 46372 1251_Influenza_B_virus_(B/Lee/1940)_segment_4_g_2 46373 1251_Influenza_B_virus_(B/Lee/1940)_segment_4_g_3 46374 1251_Influenza_B_virus_(B/Lee/1940)_segment_4_g_4 46375 1251_Influenza_B_virus_(B/Lee/1940)_segment_4_g_5 46376 1252_Influenza_B_virus_(B/Lee/1940)_segment_4_g_1 46377 1252_Influenza_B_virus_(B/Lee/1940)_segment_4_g_2 46378 1252_Influenza_B_virus_(B/Lee/1940)_segment_4_g_3 46379 1252_Influenza_B_virus_(B/Lee/1940)_segment_4_g_4 46380 1252_Influenza_B_virus_(B/Lee/1940)_segment_4_g_5 46381 1253_Influenza_B_virus_(B/Lee/1940)_segment_4_g_1 46382 1253_Influenza_B_virus_(B/Lee/1940)_segment_4_g_2 46383 1253_Influenza_B_virus_(B/Lee/1940)_segment_4_g_3 46384 1253_Influenza_B_virus_(B/Lee/1940)_segment_4_g_4 46385 1253_Influenza_B_virus_(B/Lee/1940)_segment_4_g_5 46386 1254_Influenza_B_virus_(B/Lee/1940)_segment_4_g_1 46387 1254_Influenza_B_virus_(B/Lee/1940)_segment_4_g_2 46388 1254_Influenza_B_virus_(B/Lee/1940)_segment_4_g_3 46389 1254_Influenza_B_virus_(B/Lee/1940)_segment_4_g_4 46390 1254_Influenza_B_virus_(B/Lee/1940)_segment_4_g_5 46391 1255_Influenza_B_virus_(B/Lee/1940)_segment_4_g_1 46392 1255_Influenza_B_virus_(B/Lee/1940)_segment_4_g_2 46393 1255_Influenza_B_virus_(B/Lee/1940)_segment_4_g_3 46394 1255_Influenza_B_virus_(B/Lee/1940)_segment_4_g_4 46395 1255_Influenza_B_virus_(B/Lee/1940)_segment_4_g_5 46396 1256_Influenza_B_virus_(B/Lee/1940)_segment_4_g_1 46397 1256_Influenza_B_virus_(B/Lee/1940)_segment_4_g_2 46398 1256_Influenza_B_virus_(B/Lee/1940)_segment_4_g_3 46399 1256_Influenza_B_virus_(B/Lee/1940)_segment_4_g_4 46400 1256_Influenza_B_virus_(B/Lee/1940)_segment_4_g_5 46401 1257_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_1 46402 1257_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_2 46403 1257_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_3 46404 1257_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_4 46405 1257_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_5 46406 1258_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_1 46407 1258_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_2 46408 1259_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_1 46409 1259_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_2 46410 1259_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_3 46411 1259_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_4 46412 1259_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_segment_7_g_5 46413 1260_Human_papillomavirus_type_161_isolate_KC1_g_1 46414 1260_Human_papillomavirus_type_161_isolate_KC1_g_2 46415 1260_Human_papillomavirus_type_161_isolate_KC1_g_3 46416 1260_Human_papillomavirus_type_161_isolate_KC1_g_4 46417 1260_Human_papillomavirus_type_161_isolate_KC1_g_5 46418 1261_Human_papillomavirus_type_161_isolate_KC1_g_1 46419 1261_Human_papillomavirus_type_161_isolate_KC1_g_2 46420 1261_Human_papillomavirus_type_161_isolate_KC1_g_3 46421 1261_Human_papillomavirus_type_161_isolate_KC1_g_4 46422 1261_Human_papillomavirus_type_161_isolate_KC1_g_5 46423 1262_Human_papillomavirus_type_161_isolate_KC1_g_1 46424 1262_Human_papillomavirus_type_161_isolate_KC1_g_2 46425 1262_Human_papillomavirus_type_161_isolate_KC1_g_3 46426 1262_Human_papillomavirus_type_161_isolate_KC1_g_4 46427 1262_Human_papillomavirus_type_161_isolate_KC1_g_5 46428 1263_Human_papillomavirus_type_161_isolate_KC1_g_1 46429 1263_Human_papillomavirus_type_161_isolate_KC1_g_2 46430 1263_Human_papillomavirus_type_161_isolate_KC1_g_3 46431 1263_Human_papillomavirus_type_161_isolate_KC1_g_4 46432 1263_Human_papillomavirus_type_161_isolate_KC1_g_5 46433 1264_Human_papillomavirus_type_161_isolate_KC1_g_1 46434 1264_Human_papillomavirus_type_161_isolate_KC1_g_2 46435 1264_Human_papillomavirus_type_161_isolate_KC1_g_3 46436 1264_Human_papillomavirus_type_161_isolate_KC1_g_4 46437 1264_Human_papillomavirus_type_161_isolate_KC1_g_5 46438 1265_Human_papillomavirus_type_161_isolate_KC1_g_1 46439 1265_Human_papillomavirus_type_161_isolate_KC1_g_2 46440 1265_Human_papillomavirus_type_161_isolate_KC1_g_3 46441 1265_Human_papillomavirus_type_161_isolate_KC1_g_4 46442 1265_Human_papillomavirus_type_161_isolate_KC1_g_5 46443 1266_Human_papillomavirus_type_161_isolate_KC1_g_1 46444 1266_Human_papillomavirus_type_161_isolate_KC1_g_2 46445 1266_Human_papillomavirus_type_161_isolate_KC1_g_3 46446 1266_Human_papillomavirus_type_161_isolate_KC1_g_4 46447 1266_Human_papillomavirus_type_161_isolate_KC1_g_5 46448 1267_Human_papillomavirus_type_161_isolate_KC1_g_1 46449 1267_Human_papillomavirus_type_161_isolate_KC1_g_2 46450 1267_Human_papillomavirus_type_161_isolate_KC1_g_3 46451 1267_Human_papillomavirus_type_161_isolate_KC1_g_4 46452 1267_Human_papillomavirus_type_161_isolate_KC1_g_5 46453 1268_Human_papillomavirus_type_161_isolate_KC1_g_1 46454 1268_Human_papillomavirus_type_161_isolate_KC1_g_2 46455 1268_Human_papillomavirus_type_161_isolate_KC1_g_3 46456 1268_Human_papillomavirus_type_161_isolate_KC1_g_4 46457 1268_Human_papillomavirus_type_161_isolate_KC1_g_5 46458 1269_Human_papillomavirus_type_161_isolate_KC1_g_1 46459 1269_Human_papillomavirus_type_161_isolate_KC1_g_2 46460 1269_Human_papillomavirus_type_161_isolate_KC1_g_3 46461 1269_Human_papillomavirus_type_161_isolate_KC1_g_4 46462 1269_Human_papillomavirus_type_161_isolate_KC1_g_5 46463 1270_Human_papillomavirus_type_161_isolate_KC1_g_1 46464 1270_Human_papillomavirus_type_161_isolate_KC1_g_2 46465 1270_Human_papillomavirus_type_161_isolate_KC1_g_3 46466 1270_Human_papillomavirus_type_161_isolate_KC1_g_4 46467 1270_Human_papillomavirus_type_161_isolate_KC1_g_5 46468 1271_Human_papillomavirus_type_161_isolate_KC1_g_1 46469 1271_Human_papillomavirus_type_161_isolate_KC1_g_2 46470 1271_Human_papillomavirus_type_161_isolate_KC1_g_3 46471 1271_Human_papillomavirus_type_161_isolate_KC1_g_4 46472 1271_Human_papillomavirus_type_161_isolate_KC1_g_5 46473 1272_Human_papillomavirus_type_161_isolate_KC1_g_1 46474 1272_Human_papillomavirus_type_161_isolate_KC1_g_2 46475 1272_Human_papillomavirus_type_161_isolate_KC1_g_3 46476 1272_Human_papillomavirus_type_161_isolate_KC1_g_4 46477 1272_Human_papillomavirus_type_161_isolate_KC1_g_5 46478 1273_Human_papillomavirus_type_161_isolate_KC1_g_1 46479 1273_Human_papillomavirus_type_161_isolate_KC1_g_2 46480 1273_Human_papillomavirus_type_161_isolate_KC1_g_3 46481 1273_Human_papillomavirus_type_161_isolate_KC1_g_4 46482 1273_Human_papillomavirus_type_161_isolate_KC1_g_5 46483 1274_Human_papillomavirus_type_161_isolate_KC1_g_1 46484 1274_Human_papillomavirus_type_161_isolate_KC1_g_2 46485 1274_Human_papillomavirus_type_161_isolate_KC1_g_3 46486 1274_Human_papillomavirus_type_161_isolate_KC1_g_4 46487 1274_Human_papillomavirus_type_161_isolate_KC1_g_5 46488 1275_Human_papillomavirus_type_154_isolate_PV77_g_1 46489 1275_Human_papillomavirus_type_154_isolate_PV77_g_2 46490 1275_Human_papillomavirus_type_154_isolate_PV77_g_3 46491 1275_Human_papillomavirus_type_154_isolate_PV77_g_4 46492 1275_Human_papillomavirus_type_154_isolate_PV77_g_5 46493 1276_Human_papillomavirus_type_154_isolate_PV77_g_1 46494 1276_Human_papillomavirus_type_154_isolate_PV77_g_2 46495 1276_Human_papillomavirus_type_154_isolate_PV77_g_3 46496 1276_Human_papillomavirus_type_154_isolate_PV77_g_4 46497 1276_Human_papillomavirus_type_154_isolate_PV77_g_5 46498 1277_Human_papillomavirus_type_154_isolate_PV77_g_1 46499 1277_Human_papillomavirus_type_154_isolate_PV77_g_2 46500 1277_Human_papillomavirus_type_154_isolate_PV77_g_3 46501 1277_Human_papillomavirus_type_154_isolate_PV77_g_4 46502 1277_Human_papillomavirus_type_154_isolate_PV77_g_5 46503 1278_Human_papillomavirus_type_154_isolate_PV77_g_1 46504 1278_Human_papillomavirus_type_154_isolate_PV77_g_2 46505 1278_Human_papillomavirus_type_154_isolate_PV77_g_3 46506 1278_Human_papillomavirus_type_154_isolate_PV77_g_4 46507 1278_Human_papillomavirus_type_154_isolate_PV77_g_5 46508 1279_Human_papillomavirus_type_154_isolate_PV77_g_1 46509 1279_Human_papillomavirus_type_154_isolate_PV77_g_2 46510 1279_Human_papillomavirus_type_154_isolate_PV77_g_3 46511 1279_Human_papillomavirus_type_154_isolate_PV77_g_4 46512 1279_Human_papillomavirus_type_154_isolate_PV77_g_5 46513 1280_Human_papillomavirus_type_154_isolate_PV77_g_1 46514 1280_Human_papillomavirus_type_154_isolate_PV77_g_2 46515 1280_Human_papillomavirus_type_154_isolate_PV77_g_3 46516 1280_Human_papillomavirus_type_154_isolate_PV77_g_4 46517 1280_Human_papillomavirus_type_154_isolate_PV77_g_5 46518 1281_Human_papillomavirus_type_154_isolate_PV77_g_1 46519 1281_Human_papillomavirus_type_154_isolate_PV77_g_2 46520 1281_Human_papillomavirus_type_154_isolate_PV77_g_3 46521 1281_Human_papillomavirus_type_154_isolate_PV77_g_4 46522 1281_Human_papillomavirus_type_154_isolate_PV77_g_5 46523 1282_Human_papillomavirus_type_154_isolate_PV77_g_1 46524 1282_Human_papillomavirus_type_154_isolate_PV77_g_2 46525 1282_Human_papillomavirus_type_154_isolate_PV77_g_3 46526 1282_Human_papillomavirus_type_154_isolate_PV77_g_4 46527 1282_Human_papillomavirus_type_154_isolate_PV77_g_5 46528 1283_Human_papillomavirus_type_154_isolate_PV77_g_1 46529 1283_Human_papillomavirus_type_154_isolate_PV77_g_2 46530 1283_Human_papillomavirus_type_154_isolate_PV77_g_3 46531 1283_Human_papillomavirus_type_154_isolate_PV77_g_4 46532 1283_Human_papillomavirus_type_154_isolate_PV77_g_5 46533 1284_Human_papillomavirus_type_154_isolate_PV77_g_1 46534 1284_Human_papillomavirus_type_154_isolate_PV77_g_2 46535 1284_Human_papillomavirus_type_154_isolate_PV77_g_3 46536 1284_Human_papillomavirus_type_154_isolate_PV77_g_4 46537 1284_Human_papillomavirus_type_154_isolate_PV77_g_5 46538 1285_Human_papillomavirus_type_154_isolate_PV77_g_1 46539 1285_Human_papillomavirus_type_154_isolate_PV77_g_2 46540 1285_Human_papillomavirus_type_154_isolate_PV77_g_3 46541 1285_Human_papillomavirus_type_154_isolate_PV77_g_4 46542 1285_Human_papillomavirus_type_154_isolate_PV77_g_5 46543 1286_Human_papillomavirus_type_154_isolate_PV77_g_1 46544 1286_Human_papillomavirus_type_154_isolate_PV77_g_2 46545 1286_Human_papillomavirus_type_154_isolate_PV77_g_3 46546 1286_Human_papillomavirus_type_154_isolate_PV77_g_4 46547 1286_Human_papillomavirus_type_154_isolate_PV77_g_5 46548 1287_Human_papillomavirus_type_154_isolate_PV77_g_1 46549 1287_Human_papillomavirus_type_154_isolate_PV77_g_2 46550 1287_Human_papillomavirus_type_154_isolate_PV77_g_3 46551 1287_Human_papillomavirus_type_154_isolate_PV77_g_4 46552 1287_Human_papillomavirus_type_154_isolate_PV77_g_5 46553 1288_Human_papillomavirus_type_154_isolate_PV77_g_1 46554 1288_Human_papillomavirus_type_154_isolate_PV77_g_2 46555 1288_Human_papillomavirus_type_154_isolate_PV77_g_3 46556 1288_Human_papillomavirus_type_154_isolate_PV77_g_4 46557 1288_Human_papillomavirus_type_154_isolate_PV77_g_5 46558 1289_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_1 46559 1289_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_2 46560 1289_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_3 46561 1289_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_4 46562 1289_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_5 46563 1290_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_1 46564 1290_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_2 46565 1290_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_3 46566 1290_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_4 46567 1290_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_5 46568 1291_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_1 46569 1291_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_2 46570 1291_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_3 46571 1291_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_4 46572 1291_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_5 46573 1292_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_1 46574 1292_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_2 46575 1292_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_3 46576 1292_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_4 46577 1292_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_5 46578 1293_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_1 46579 1293_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_2 46580 1293_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_3 46581 1293_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_4 46582 1293_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_5 46583 1294_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_1 46584 1294_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_2 46585 1294_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_3 46586 1294_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_4 46587 1294_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_5 46588 1295_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_1 46589 1295_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_2 46590 1295_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_3 46591 1295_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_4 46592 1295_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_5 46593 1296_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_1 46594 1296_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_2 46595 1296_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_3 46596 1296_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_4 46597 1296_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_5 46598 1297_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_1 46599 1297_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_2 46600 1297_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_3 46601 1297_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_4 46602 1297_Influenza_A_virus_PB2_gene_for_polymerase_Pb2_g_5 46603 1298_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46604 segment_4_hemagglutinin_(HA)_gene_g_1 1298_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46605 segment_4_hemagglutinin_(HA)_gene_g_2 1298_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46606 segment_4_hemagglutinin_(HA)_gene_g_3 1298_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46607 segment_4_hemagglutinin_(HA)_gene_g_4 1298_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46608 segment_4_hemagglutinin_(HA)_gene_g_5 1299_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46609 segment_4_hemagglutinin_(HA)_gene_g_1 1299_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46610 segment_4_hemagglutinin_(HA)_gene_g_2 1299_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46611 segment_4_hemagglutinin_(HA)_gene_g_3 1299_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46612 segment_4_hemagglutinin_(HA)_gene_g_4 1299_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46613 segment_4_hemagglutinin_(HA)_gene_g_5 1300_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46614 segment_4_hemagglutinin_(HA)_gene_g_1 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1302_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46625 segment_4_hemagglutinin_(HA)_gene_g_2 1302_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46626 segment_4_hemagglutinin_(HA)_gene_g_3 1302_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46627 segment_4_hemagglutinin_(HA)_gene_g_4 1302_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46628 segment_4_hemagglutinin_(HA)_gene_g_5 1303_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46629 segment_4_hemagglutinin_(HA)_gene_g_1 1303_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46630 segment_4_hemagglutinin_(HA)_gene_g_2 1303_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46631 segment_4_hemagglutinin_(HA)_gene_g_3 1303_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46632 segment_4_hemagglutinin_(HA)_gene_g_4 1303_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 46633 segment_4_hemagglutinin_(HA)_gene_g_5 1304_Human_papillomavirus_type_32_g_1 46634 1304_Human_papillomavirus_type_32_g_2 46635 1304_Human_papillomavirus_type_32_g_3 46636 1304_Human_papillomavirus_type_32_g_4 46637 1304_Human_papillomavirus_type_32_g_5 46638 1305_Human_papillomavirus_type_32_g_1 46639 1305_Human_papillomavirus_type_32_g_2 46640 1305_Human_papillomavirus_type_32_g_3 46641 1305_Human_papillomavirus_type_32_g_4 46642 1305_Human_papillomavirus_type_32_g_5 46643 1306_Human_papillomavirus_type_32_g_1 46644 1306_Human_papillomavirus_type_32_g_2 46645 1306_Human_papillomavirus_type_32_g_3 46646 1306_Human_papillomavirus_type_32_g_4 46647 1306_Human_papillomavirus_type_32_g_5 46648 1307_Human_papillomavirus_type_32_g_1 46649 1307_Human_papillomavirus_type_32_g_2 46650 1307_Human_papillomavirus_type_32_g_3 46651 1307_Human_papillomavirus_type_32_g_4 46652 1307_Human_papillomavirus_type_32_g_5 46653 1308_Human_papillomavirus_type_32_g_1 46654 1308_Human_papillomavirus_type_32_g_2 46655 1308_Human_papillomavirus_type_32_g_3 46656 1308_Human_papillomavirus_type_32_g_4 46657 1308_Human_papillomavirus_type_32_g_5 46658 1309_Human_papillomavirus_type_32_g_1 46659 1309_Human_papillomavirus_type_32_g_2 46660 1309_Human_papillomavirus_type_32_g_3 46661 1309_Human_papillomavirus_type_32_g_4 46662 1309_Human_papillomavirus_type_32_g_5 46663 1310_Human_papillomavirus_type_32_g_1 46664 1310_Human_papillomavirus_type_32_g_2 46665 1310_Human_papillomavirus_type_32_g_3 46666 1310_Human_papillomavirus_type_32_g_4 46667 1310_Human_papillomavirus_type_32_g_5 46668 1311_Human_papillomavirus_type_32_g_1 46669 1311_Human_papillomavirus_type_32_g_2 46670 1311_Human_papillomavirus_type_32_g_3 46671 1311_Human_papillomavirus_type_32_g_4 46672 1311_Human_papillomavirus_type_32_g_5 46673 1312_Human_papillomavirus_type_32_g_1 46674 1312_Human_papillomavirus_type_32_g_2 46675 1312_Human_papillomavirus_type_32_g_3 46676 1312_Human_papillomavirus_type_32_g_4 46677 1312_Human_papillomavirus_type_32_g_5 46678 1313_Human_papillomavirus_type_32_g_1 46679 1313_Human_papillomavirus_type_32_g_2 46680 1313_Human_papillomavirus_type_32_g_3 46681 1313_Human_papillomavirus_type_32_g_4 46682 1313_Human_papillomavirus_type_32_g_5 46683 1314_Human_papillomavirus_type_32_g_1 46684 1314_Human_papillomavirus_type_32_g_2 46685 1314_Human_papillomavirus_type_32_g_3 46686 1314_Human_papillomavirus_type_32_g_4 46687 1314_Human_papillomavirus_type_32_g_5 46688 1315_Human_papillomavirus_type_32_g_1 46689 1315_Human_papillomavirus_type_32_g_2 46690 1315_Human_papillomavirus_type_32_g_3 46691 1315_Human_papillomavirus_type_32_g_4 46692 1315_Human_papillomavirus_type_32_g_5 46693 1316_Human_papillomavirus_type_32_g_1 46694 1316_Human_papillomavirus_type_32_g_2 46695 1316_Human_papillomavirus_type_32_g_3 46696 1316_Human_papillomavirus_type_32_g_4 46697 1316_Human_papillomavirus_type_32_g_5 46698 1317_Human_papillomavirus_type_32_g_1 46699 1317_Human_papillomavirus_type_32_g_2 46700 1317_Human_papillomavirus_type_32_g_3 46701 1317_Human_papillomavirus_type_32_g_4 46702 1317_Human_papillomavirus_type_32_g_5 46703 1318_Human_papillomavirus_type_32_g_1 46704 1318_Human_papillomavirus_type_32_g_2 46705 1318_Human_papillomavirus_type_32_g_3 46706 1318_Human_papillomavirus_type_32_g_4 46707 1318_Human_papillomavirus_type_32_g_5 46708 1319_Human_papillomavirus_type_32_g_1 46709 1319_Human_papillomavirus_type_32_g_2 46710 1319_Human_papillomavirus_type_32_g_3 46711 1319_Human_papillomavirus_type_32_g_4 46712 1319_Human_papillomavirus_type_32_g_5 46713 1320_Human_papillomavirus_type_32_g_1 46714 1320_Human_papillomavirus_type_32_g_2 46715 1320_Human_papillomavirus_type_32_g_3 46716 1320_Human_papillomavirus_type_32_g_4 46717 1320_Human_papillomavirus_type_32_g_5 46718 1321_Human_papillomavirus_type_136_g_1 46719 1321_Human_papillomavirus_type_136_g_2 46720 1321_Human_papillomavirus_type_136_g_3 46721 1321_Human_papillomavirus_type_136_g_4 46722 1321_Human_papillomavirus_type_136_g_5 46723 1322_Human_papillomavirus_type_136_g_1 46724 1322_Human_papillomavirus_type_136_g_2 46725 1322_Human_papillomavirus_type_136_g_3 46726 1322_Human_papillomavirus_type_136_g_4 46727 1322_Human_papillomavirus_type_136_g_5 46728 1323_Human_papillomavirus_type_136_g_1 46729 1323_Human_papillomavirus_type_136_g_2 46730 1323_Human_papillomavirus_type_136_g_3 46731 1323_Human_papillomavirus_type_136_g_4 46732 1323_Human_papillomavirus_type_136_g_5 46733 1324_Human_papillomavirus_type_136_g_1 46734 1324_Human_papillomavirus_type_136_g_2 46735 1324_Human_papillomavirus_type_136_g_3 46736 1324_Human_papillomavirus_type_136_g_4 46737 1324_Human_papillomavirus_type_136_g_5 46738 1325_Human_papillomavirus_type_136_g_1 46739 1325_Human_papillomavirus_type_136_g_2 46740 1325_Human_papillomavirus_type_136_g_3 46741 1325_Human_papillomavirus_type_136_g_4 46742 1325_Human_papillomavirus_type_136_g_5 46743 1326_Human_papillomavirus_type_136_g_1 46744 1326_Human_papillomavirus_type_136_g_2 46745 1326_Human_papillomavirus_type_136_g_3 46746 1326_Human_papillomavirus_type_136_g_4 46747 1326_Human_papillomavirus_type_136_g_5 46748 1327_Human_papillomavirus_type_136_g_1 46749 1327_Human_papillomavirus_type_136_g_2 46750 1327_Human_papillomavirus_type_136_g_3 46751 1327_Human_papillomavirus_type_136_g_4 46752 1327_Human_papillomavirus_type_136_g_5 46753 1328_Human_papillomavirus_type_136_g_1 46754 1328_Human_papillomavirus_type_136_g_2 46755 1328_Human_papillomavirus_type_136_g_3 46756 1328_Human_papillomavirus_type_136_g_4 46757 1328_Human_papillomavirus_type_136_g_5 46758 1329_Human_papillomavirus_type_136_g_1 46759 1329_Human_papillomavirus_type_136_g_2 46760 1329_Human_papillomavirus_type_136_g_3 46761 1329_Human_papillomavirus_type_136_g_4 46762 1329_Human_papillomavirus_type_136_g_5 46763 1330_Human_papillomavirus_type_136_g_1 46764 1330_Human_papillomavirus_type_136_g_2 46765 1330_Human_papillomavirus_type_136_g_3 46766 1330_Human_papillomavirus_type_136_g_4 46767 1330_Human_papillomavirus_type_136_g_5 46768 1331_Human_papillomavirus_type_136_g_1 46769 1331_Human_papillomavirus_type_136_g_2 46770 1331_Human_papillomavirus_type_136_g_3 46771 1331_Human_papillomavirus_type_136_g_4 46772 1331_Human_papillomavirus_type_136_g_5 46773 1332_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_1 46774 1332_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_2 46775 1332_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_3 46776 1332_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_4 46777 1332_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_5 46778 1333_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_1 46779 1333_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_2 46780 1333_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_3 46781 1333_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_4 46782 1333_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_segment_7_g_5 46783 1334_Human_parainfluenza_virus_3_g_1 46784 1334_Human_parainfluenza_virus_3_g_2 46785 1334_Human_parainfluenza_virus_3_g_3 46786 1334_Human_parainfluenza_virus_3_g_4 46787 1334_Human_parainfluenza_virus_3_g_5 46788 1335_Human_parainfluenza_virus_3_g_1 46789 1335_Human_parainfluenza_virus_3_g_2 46790 1335_Human_parainfluenza_virus_3_g_3 46791 1335_Human_parainfluenza_virus_3_g_4 46792 1335_Human_parainfluenza_virus_3_g_5 46793 1336_Human_parainfluenza_virus_3_g_1 46794 1336_Human_parainfluenza_virus_3_g_2 46795 1336_Human_parainfluenza_virus_3_g_3 46796 1336_Human_parainfluenza_virus_3_g_4 46797 1336_Human_parainfluenza_virus_3_g_5 46798 1337_Human_parainfluenza_virus_3_g_1 46799 1337_Human_parainfluenza_virus_3_g_2 46800 1337_Human_parainfluenza_virus_3_g_3 46801 1337_Human_parainfluenza_virus_3_g_4 46802 1337_Human_parainfluenza_virus_3_g_5 46803 1338_Human_parainfluenza_virus_3_g_1 46804 1338_Human_parainfluenza_virus_3_g_2 46805 1338_Human_parainfluenza_virus_3_g_3 46806 1338_Human_parainfluenza_virus_3_g_4 46807 1338_Human_parainfluenza_virus_3_g_5 46808 1339_Human_parainfluenza_virus_3_g_1 46809 1339_Human_parainfluenza_virus_3_g_2 46810 1339_Human_parainfluenza_virus_3_g_3 46811 1339_Human_parainfluenza_virus_3_g_4 46812 1339_Human_parainfluenza_virus_3_g_5 46813 1340_Human_parainfluenza_virus_3_g_1 46814 1340_Human_parainfluenza_virus_3_g_2 46815 1340_Human_parainfluenza_virus_3_g_3 46816 1340_Human_parainfluenza_virus_3_g_4 46817 1340_Human_parainfluenza_virus_3_g_5 46818 1341_Human_parainfluenza_virus_3_g_1 46819 1341_Human_parainfluenza_virus_3_g_2 46820 1341_Human_parainfluenza_virus_3_g_3 46821 1341_Human_parainfluenza_virus_3_g_4 46822 1341_Human_parainfluenza_virus_3_g_5 46823 1342_Human_parainfluenza_virus_3_g_1 46824 1342_Human_parainfluenza_virus_3_g_2 46825 1342_Human_parainfluenza_virus_3_g_3 46826 1342_Human_parainfluenza_virus_3_g_4 46827 1342_Human_parainfluenza_virus_3_g_5 46828 1343_Human_parainfluenza_virus_3_g_1 46829 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1516_Human_gammaherpesvirus_4_g_2 47654 1517_Human_gammaherpesvirus_4_g_1 47655 1517_Human_gammaherpesvirus_4_g_2 47656 1517_Human_gammaherpesvirus_4_g_3 47657 1517_Human_gammaherpesvirus_4_g_4 47658 1517_Human_gammaherpesvirus_4_g_5 47659 1518_Human_gammaherpesvirus_4_g_1 47660 1518_Human_gammaherpesvirus_4_g_2 47661 1518_Human_gammaherpesvirus_4_g_3 47662 1518_Human_gammaherpesvirus_4_g_4 47663 1518_Human_gammaherpesvirus_4_g_5 47664 1519_Human_gammaherpesvirus_4_g_1 47665 1519_Human_gammaherpesvirus_4_g_2 47666 1519_Human_gammaherpesvirus_4_g_3 47667 1519_Human_gammaherpesvirus_4_g_4 47668 1520_Human_gammaherpesvirus_4_g_1 47669 1520_Human_gammaherpesvirus_4_g_2 47670 1520_Human_gammaherpesvirus_4_g_3 47671 1520_Human_gammaherpesvirus_4_g_4 47672 1520_Human_gammaherpesvirus_4_g_5 47673 1521_Human_gammaherpesvirus_4_g_1 47674 1521_Human_gammaherpesvirus_4_g_2 47675 1521_Human_gammaherpesvirus_4_g_3 47676 1521_Human_gammaherpesvirus_4_g_4 47677 1521_Human_gammaherpesvirus_4_g_5 47678 1522_Human_gammaherpesvirus_4_g_1 47679 1522_Human_gammaherpesvirus_4_g_2 47680 1522_Human_gammaherpesvirus_4_g_3 47681 1522_Human_gammaherpesvirus_4_g_4 47682 1522_Human_gammaherpesvirus_4_g_5 47683 1523_Human_gammaherpesvirus_4_g_1 47684 1523_Human_gammaherpesvirus_4_g_2 47685 1523_Human_gammaherpesvirus_4_g_3 47686 1523_Human_gammaherpesvirus_4_g_4 47687 1524_Human_gammaherpesvirus_4_g_1 47688 1524_Human_gammaherpesvirus_4_g_2 47689 1524_Human_gammaherpesvirus_4_g_3 47690 1524_Human_gammaherpesvirus_4_g_4 47691 1524_Human_gammaherpesvirus_4_g_5 47692 1525_Human_gammaherpesvirus_4_g_1 47693 1525_Human_gammaherpesvirus_4_g_2 47694 1525_Human_gammaherpesvirus_4_g_3 47695 1525_Human_gammaherpesvirus_4_g_4 47696 1525_Human_gammaherpesvirus_4_g_5 47697 1526_Human_gammaherpesvirus_4_g_1 47698 1526_Human_gammaherpesvirus_4_g_2 47699 1526_Human_gammaherpesvirus_4_g_3 47700 1527_Human_gammaherpesvirus_4_g_1 47701 1527_Human_gammaherpesvirus_4_g_2 47702 1527_Human_gammaherpesvirus_4_g_3 47703 1527_Human_gammaherpesvirus_4_g_4 47704 1527_Human_gammaherpesvirus_4_g_5 47705 1528_Human_gammaherpesvirus_4_g_1 47706 1528_Human_gammaherpesvirus_4_g_2 47707 1528_Human_gammaherpesvirus_4_g_3 47708 1528_Human_gammaherpesvirus_4_g_4 47709 1528_Human_gammaherpesvirus_4_g_5 47710 1529_Human_gammaherpesvirus_4_g_1 47711 1529_Human_gammaherpesvirus_4_g_2 47712 1529_Human_gammaherpesvirus_4_g_3 47713 1529_Human_gammaherpesvirus_4_g_4 47714 1529_Human_gammaherpesvirus_4_g_5 47715 1530_Human_gammaherpesvirus_4_g_1 47716 1530_Human_gammaherpesvirus_4_g_2 47717 1530_Human_gammaherpesvirus_4_g_3 47718 1530_Human_gammaherpesvirus_4_g_4 47719 1530_Human_gammaherpesvirus_4_g_5 47720 1531_Human_gammaherpesvirus_4_g_1 47721 1531_Human_gammaherpesvirus_4_g_2 47722 1531_Human_gammaherpesvirus_4_g_3 47723 1531_Human_gammaherpesvirus_4_g_4 47724 1531_Human_gammaherpesvirus_4_g_5 47725 1532_Human_gammaherpesvirus_4_g_1 47726 1532_Human_gammaherpesvirus_4_g_2 47727 1532_Human_gammaherpesvirus_4_g_3 47728 1532_Human_gammaherpesvirus_4_g_4 47729 1532_Human_gammaherpesvirus_4_g_5 47730 1533_Human_gammaherpesvirus_4_g_1 47731 1533_Human_gammaherpesvirus_4_g_2 47732 1533_Human_gammaherpesvirus_4_g_3 47733 1533_Human_gammaherpesvirus_4_g_4 47734 1533_Human_gammaherpesvirus_4_g_5 47735 1534_Human_gammaherpesvirus_4_g_1 47736 1534_Human_gammaherpesvirus_4_g_2 47737 1534_Human_gammaherpesvirus_4_g_3 47738 1534_Human_gammaherpesvirus_4_g_4 47739 1534_Human_gammaherpesvirus_4_g_5 47740 1535_Human_gammaherpesvirus_4_g_1 47741 1535_Human_gammaherpesvirus_4_g_2 47742 1537_Human_gammaherpesvirus_4_g_1 47743 1538_Human_gammaherpesvirus_4_g_1 47744 1538_Human_gammaherpesvirus_4_g_2 47745 1538_Human_gammaherpesvirus_4_g_3 47746 1539_Human_gammaherpesvirus_4_g_1 47747 1539_Human_gammaherpesvirus_4_g_2 47748 1539_Human_gammaherpesvirus_4_g_3 47749 1539_Human_gammaherpesvirus_4_g_4 47750 1539_Human_gammaherpesvirus_4_g_5 47751 1540_Human_gammaherpesvirus_4_g_1 47752 1540_Human_gammaherpesvirus_4_g_2 47753 1540_Human_gammaherpesvirus_4_g_3 47754 1540_Human_gammaherpesvirus_4_g_4 47755 1541_Human_gammaherpesvirus_4_g_1 47756 1541_Human_gammaherpesvirus_4_g_2 47757 1541_Human_gammaherpesvirus_4_g_3 47758 1541_Human_gammaherpesvirus_4_g_4 47759 1542_Human_gammaherpesvirus_4_g_1 47760 1542_Human_gammaherpesvirus_4_g_2 47761 1542_Human_gammaherpesvirus_4_g_3 47762 1542_Human_gammaherpesvirus_4_g_4 47763 1542_Human_gammaherpesvirus_4_g_5 47764 1543_Human_gammaherpesvirus_4_g_1 47765 1543_Human_gammaherpesvirus_4_g_2 47766 1543_Human_gammaherpesvirus_4_g_3 47767 1543_Human_gammaherpesvirus_4_g_4 47768 1543_Human_gammaherpesvirus_4_g_5 47769 1544_Human_papillomavirus_type_156_isolate_GC01_g_1 47770 1544_Human_papillomavirus_type_156_isolate_GC01_g_2 47771 1544_Human_papillomavirus_type_156_isolate_GC01_g_3 47772 1544_Human_papillomavirus_type_156_isolate_GC01_g_4 47773 1544_Human_papillomavirus_type_156_isolate_GC01_g_5 47774 1545_Human_papillomavirus_type_156_isolate_GC01_g_1 47775 1545_Human_papillomavirus_type_156_isolate_GC01_g_2 47776 1545_Human_papillomavirus_type_156_isolate_GC01_g_3 47777 1545_Human_papillomavirus_type_156_isolate_GC01_g_4 47778 1545_Human_papillomavirus_type_156_isolate_GC01_g_5 47779 1546_Human_papillomavirus_type_156_isolate_GC01_g_1 47780 1546_Human_papillomavirus_type_156_isolate_GC01_g_2 47781 1546_Human_papillomavirus_type_156_isolate_GC01_g_3 47782 1546_Human_papillomavirus_type_156_isolate_GC01_g_4 47783 1546_Human_papillomavirus_type_156_isolate_GC01_g_5 47784 1547_Human_papillomavirus_type_156_isolate_GC01_g_1 47785 1547_Human_papillomavirus_type_156_isolate_GC01_g_2 47786 1547_Human_papillomavirus_type_156_isolate_GC01_g_3 47787 1547_Human_papillomavirus_type_156_isolate_GC01_g_4 47788 1547_Human_papillomavirus_type_156_isolate_GC01_g_5 47789 1548_Human_papillomavirus_type_156_isolate_GC01_g_1 47790 1548_Human_papillomavirus_type_156_isolate_GC01_g_2 47791 1548_Human_papillomavirus_type_156_isolate_GC01_g_3 47792 1548_Human_papillomavirus_type_156_isolate_GC01_g_4 47793 1548_Human_papillomavirus_type_156_isolate_GC01_g_5 47794 1549_Human_papillomavirus_type_156_isolate_GC01_g_1 47795 1549_Human_papillomavirus_type_156_isolate_GC01_g_2 47796 1549_Human_papillomavirus_type_156_isolate_GC01_g_3 47797 1549_Human_papillomavirus_type_156_isolate_GC01_g_4 47798 1549_Human_papillomavirus_type_156_isolate_GC01_g_5 47799 1550_Human_papillomavirus_type_156_isolate_GC01_g_1 47800 1550_Human_papillomavirus_type_156_isolate_GC01_g_2 47801 1550_Human_papillomavirus_type_156_isolate_GC01_g_3 47802 1550_Human_papillomavirus_type_156_isolate_GC01_g_4 47803 1550_Human_papillomavirus_type_156_isolate_GC01_g_5 47804 1551_Human_papillomavirus_type_156_isolate_GC01_g_1 47805 1551_Human_papillomavirus_type_156_isolate_GC01_g_2 47806 1551_Human_papillomavirus_type_156_isolate_GC01_g_3 47807 1551_Human_papillomavirus_type_156_isolate_GC01_g_4 47808 1551_Human_papillomavirus_type_156_isolate_GC01_g_5 47809 1552_Human_papillomavirus_type_156_isolate_GC01_g_1 47810 1552_Human_papillomavirus_type_156_isolate_GC01_g_2 47811 1552_Human_papillomavirus_type_156_isolate_GC01_g_3 47812 1552_Human_papillomavirus_type_156_isolate_GC01_g_4 47813 1552_Human_papillomavirus_type_156_isolate_GC01_g_5 47814 1553_Human_papillomavirus_type_156_isolate_GC01_g_1 47815 1553_Human_papillomavirus_type_156_isolate_GC01_g_2 47816 1553_Human_papillomavirus_type_156_isolate_GC01_g_3 47817 1553_Human_papillomavirus_type_156_isolate_GC01_g_4 47818 1553_Human_papillomavirus_type_156_isolate_GC01_g_5 47819 1554_Human_papillomavirus_type_156_isolate_GC01_g_1 47820 1554_Human_papillomavirus_type_156_isolate_GC01_g_2 47821 1554_Human_papillomavirus_type_156_isolate_GC01_g_3 47822 1554_Human_papillomavirus_type_156_isolate_GC01_g_4 47823 1554_Human_papillomavirus_type_156_isolate_GC01_g_5 47824 1555_Human_papillomavirus_type_156_isolate_GC01_g_1 47825 1555_Human_papillomavirus_type_156_isolate_GC01_g_2 47826 1555_Human_papillomavirus_type_156_isolate_GC01_g_3 47827 1555_Human_papillomavirus_type_156_isolate_GC01_g_4 47828 1555_Human_papillomavirus_type_156_isolate_GC01_g_5 47829 1556_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47830 segment_4_(—) g_1 1556_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47831 segment_4_(—) g_2 1556_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47832 segment_4_g_3 1556_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47833 segment_4_g_4 1556_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47834 segment_4_g_5 1557_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47835 segment_4_g_1 1557_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47836 segment_4_g_2 1557_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47837 segment_4_g_3 1557_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47838 segment_4_g_4 1557_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47839 segment_4_g_5 1558_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47840 segment_4_g_1 1558_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47841 segment_4_g_2 1558_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47842 segment_4_g_3 1558_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47843 segment_4_g_4 1558_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47844 segment_4_g_5 1559_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47845 segment_4_g_1 1559_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47846 segment_4_g_2 1559_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47847 segment_4_g_3 1559_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47848 segment_4_g_4 1559_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47849 segment_4_g_5 1560_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47850 segment_4_g_1 1560_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47851 segment_4_g_2 1560_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47852 segment_4_g_3 1560_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47853 segment_4_g_4 1560_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47854 segment_4_g_5 1561_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47855 segment_4_g_1 1561_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47856 segment_4_g_2 1561_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47857 segment_4_g_3 1561_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47858 segment_4_g_4 1561_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 47859 segment_4_g_5 1562_Human_papillomavirus_type_9_g_1 47860 1562_Human_papillomavirus_type_9_g_2 47861 1562_Human_papillomavirus_type_9_g_3 47862 1562_Human_papillomavirus_type_9_g_4 47863 1562_Human_papillomavirus_type_9_g_5 47864 1563_Human_papillomavirus_type_9_g_1 47865 1563_Human_papillomavirus_type_9_g_2 47866 1563_Human_papillomavirus_type_9_g_3 47867 1563_Human_papillomavirus_type_9_g_4 47868 1563_Human_papillomavirus_type_9_g_5 47869 1564_Human_papillomavirus_type_9_g_1 47870 1564_Human_papillomavirus_type_9_g_2 47871 1564_Human_papillomavirus_type_9_g_3 47872 1564_Human_papillomavirus_type_9_g_4 47873 1564_Human_papillomavirus_type_9_g_5 47874 1565_Human_papillomavirus_type_9_g_1 47875 1565_Human_papillomavirus_type_9_g_2 47876 1565_Human_papillomavirus_type_9_g_3 47877 1565_Human_papillomavirus_type_9_g_4 47878 1565_Human_papillomavirus_type_9_g_5 47879 1566_Human_papillomavirus_type_9_g_1 47880 1566_Human_papillomavirus_type_9_g_2 47881 1566_Human_papillomavirus_type_9_g_3 47882 1566_Human_papillomavirus_type_9_g_4 47883 1566_Human_papillomavirus_type_9_g_5 47884 1567_Human_papillomavirus_type_9_g_1 47885 1567_Human_papillomavirus_type_9_g_2 47886 1567_Human_papillomavirus_type_9_g_3 47887 1567_Human_papillomavirus_type_9_g_4 47888 1567_Human_papillomavirus_type_9_g_5 47889 1568_Human_papillomavirus_type_9_g_1 47890 1568_Human_papillomavirus_type_9_g_2 47891 1568_Human_papillomavirus_type_9_g_3 47892 1568_Human_papillomavirus_type_9_g_4 47893 1568_Human_papillomavirus_type_9_g_5 47894 1569_Human_papillomavirus_type_9_g_1 47895 1569_Human_papillomavirus_type_9_g_2 47896 1569_Human_papillomavirus_type_9_g_3 47897 1569_Human_papillomavirus_type_9_g_4 47898 1569_Human_papillomavirus_type_9_g_5 47899 1570_Human_papillomavirus_type_9_g_1 47900 1570_Human_papillomavirus_type_9_g_2 47901 1570_Human_papillomavirus_type_9_g_3 47902 1570_Human_papillomavirus_type_9_g_4 47903 1570_Human_papillomavirus_type_9_g_5 47904 1571_Human_papillomavirus_type_9_g_1 47905 1571_Human_papillomavirus_type_9_g_2 47906 1571_Human_papillomavirus_type_9_g_3 47907 1571_Human_papillomavirus_type_9_g_4 47908 1571_Human_papillomavirus_type_9_g_5 47909 1572_Human_papillomavirus_type_9_g_1 47910 1572_Human_papillomavirus_type_9_g_2 47911 1572_Human_papillomavirus_type_9_g_3 47912 1572_Human_papillomavirus_type_9_g_4 47913 1572_Human_papillomavirus_type_9_g_5 47914 1573_Human_papillomavirus_type_9_g_1 47915 1573_Human_papillomavirus_type_9_g_2 47916 1573_Human_papillomavirus_type_9_g_3 47917 1574_Human_papillomavirus_type_9_g_1 47918 1574_Human_papillomavirus_type_9_g_2 47919 1574_Human_papillomavirus_type_9_g_3 47920 1574_Human_papillomavirus_type_9_g_4 47921 1574_Human_papillomavirus_type_9_g_5 47922 1575_Human_papillomavirus_type_9_g_1 47923 1575_Human_papillomavirus_type_9_g_2 47924 1575_Human_papillomavirus_type_9_g_3 47925 1575_Human_papillomavirus_type_9_g_4 47926 1575_Human_papillomavirus_type_9_g_5 47927 1576_Human_papillomavirus_type_9_g_1 47928 1576_Human_papillomavirus_type_9_g_2 47929 1576_Human_papillomavirus_type_9_g_3 47930 1576_Human_papillomavirus_type_9_g_4 47931 1576_Human_papillomavirus_type_9_g_5 47932 1577_Human_papillomavirus_type_9_g_1 47933 1577_Human_papillomavirus_type_9_g_2 47934 1577_Human_papillomavirus_type_9_g_3 47935 1577_Human_papillomavirus_type_9_g_4 47936 1577_Human_papillomavirus_type_9_g_5 47937 1578_Human_papillomavirus_type_9_g_1 47938 1578_Human_papillomavirus_type_9_g_2 47939 1578_Human_papillomavirus_type_9_g_3 47940 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1732_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48712 1733_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48713 1733_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48714 1733_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48715 1733_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48716 1733_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48717 1734_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48718 1734_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48719 1734_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48720 1734_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48721 1734_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48722 1735_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48723 1735_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48724 1735_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48725 1735_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48726 1735_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48727 1736_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48728 1736_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48729 1736_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48730 1736_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48731 1736_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48732 1737_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48733 1737_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48734 1737_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48735 1737_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48736 1737_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48737 1738_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48738 1738_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48739 1738_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48740 1738_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48741 1738_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48742 1739_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48743 1739_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48744 1739_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48745 1739_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48746 1739_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48747 1740_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48748 1740_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48749 1740_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48750 1740_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48751 1740_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48752 1741_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48753 1741_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48754 1741_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48755 1741_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48756 1741_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48757 1742_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48758 1742_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48759 1742_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48760 1742_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48761 1742_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48762 1743_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48763 1743_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48764 1743_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48765 1743_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48766 1743_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48767 1744_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48768 1744_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48769 1744_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48770 1744_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48771 1744_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48772 1745_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48773 1745_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48774 1745_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48775 1745_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48776 1745_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48777 1746_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48778 1746_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48779 1746_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48780 1746_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48781 1746_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48782 1747_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48783 1747_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48784 1747_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48785 1747_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48786 1747_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48787 1748_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48788 1748_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48789 1748_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48790 1748_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48791 1748_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48792 1749_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48793 1749_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48794 1749_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48795 1749_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48796 1749_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48797 1750_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48798 1750_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48799 1750_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48800 1750_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48801 1750_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48802 1751_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48803 1751_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48804 1751_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48805 1751_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48806 1751_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48807 1752_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48808 1752_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48809 1752_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48810 1752_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48811 1752_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48812 1753_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_1 48813 1753_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_2 48814 1753_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_3 48815 1753_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_4 48816 1753_Chlamydia_trachomatis_D/UW-3/CX_chromosome_g_5 48817 1754_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48818 segment_5_g_1 1754_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48819 segment_5_g_2 1754_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48820 segment_5_g_3 1754_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48821 segment_5_g_4 1754_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48822 segment_5_g_5 1755_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48823 segment_5_g_1 1755_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48824 segment_5_g_2 1755_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48825 segment_5_g_3 1755_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48826 segment_5_g_4 1755_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48827 segment_5_g_5 1756_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48828 segment_5_g_1 1756_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48829 segment_5_g_2 1756_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48830 segment_5_g_3 1756_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48831 segment_s_g_4 1756_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48832 segment_5_g_5 1757_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48833 segment_5_g_1 1757_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48834 segment_5_g_2 1757_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48835 segment_5_g_3 1757_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48836 segment_5_g_4 1757_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48837 segment_5_g_5 1758_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48838 segment_6_(—) neuraminidase_(NA)_gene_g_1 1758_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48839 segment_6_(—) neuraminidase_(NA)_gene_g_2 1758_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48840 segment_6_(—) neuraminidase_(NA)_gene_g_3 1758_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48841 segment_6_(—) neuraminidase_(NA)_gene_g_4 1758_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48842 segment_6_(—) neuraminidase_(NA)_gene_g_5 1759_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48843 segment_6_(—) neuraminidase_(NA)_gene_g_1 1759_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48844 segment_6_(—) neuraminidase_(NA)_gene_g_2 1759_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48845 segment_6_(—) neuraminidase_(NA)_gene_g_3 1759_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48846 segment_6_(—) neuraminidase_(NA)_gene_g_4 1759_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48847 segment_6_(—) neuraminidase_(NA)_gene_g_5 1760_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48848 segment_6_(—) neuraminidase_(NA)_gene_g_1 1760_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48849 segment_6_(—) neuraminidase_(NA)_gene_g_2 1760_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48850 segment_6_(—) neuraminidase_(NA)_gene_g_3 1760_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48851 segment_6_(—) neuraminidase_(NA)_gene_g_4 1760_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48852 segment_6_(—) neuraminidase_(NA)_gene_g_5 1761_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48853 segment_6_(—) neuraminidase_(NA)_gene_g_1 1761_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48854 segment_6_(—) neuraminidase_(NA)_gene_g_2 1761_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48855 segment_6_(—) neuraminidase_(NA)_gene_g_3 1761_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48856 segment_6_(—) neuraminidase_(NA)_gene_g_4 1761_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 48857 segment_6_(—) neuraminidase_(NA)_gene_g_5 1762_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48858 segment_7_g_1 1762_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48859 segment_7_g_2 1762_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48860 segment_7_g_3 1762_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48861 segment_7_g_4 1762_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 48862 segment_7_g_5 1763_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48863 hemagglutinin-esterase-fusion_g_1 1763_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48864 hemagglutinin-esterase-fusion_g_2 1763_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48865 hemagglutinin-esterase-fusion_g_3 1763_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48866 hemagglutinin-esterase-fusion_g_4 1763_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48867 hemagglutinin-esterase-fusion_g_5 1764_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48868 hemagglutinin-esterase-fusion_g_1 1764_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48869 hemagglutinin-esterase-fusion_g_2 1764_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48870 hemagglutinin-esterase-fusion_g_3 1764_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48871 hemagglutinin-esterase-fusion_g_4 1764_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48872 hemagglutinin-esterase-fusion_g_5 1765_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48873 hemagglutinin-esterase-fusion_g_1 1765_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48874 hemagglutinin-esterase-fusion_g_2 1765_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48875 hemagglutinin-esterase-fusion_g_3 1765_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48876 hemagglutinin-esterase-fusion_g_4 1765_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48877 hemagglutinin-esterase-fusion_g_5 1766_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48878 hemagglutinin-esterase-fusion_g_1 1766_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48879 hemagglutinin-esterase-fusion_g_2 1766_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48880 hemagglutinin-esterase-fusion_g_3 1766_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48881 hemagglutinin-esterase-fusion_g_4 1766_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48882 hemagglutinin-esterase-fusion_g_5 1767_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48883 hemagglutinin-esterase-fusion_g_1 1767_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48884 hemagglutinin-esterase-fusion_g_2 1767_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48885 hemagglutinin-esterase-fusion_g_3 1767_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48886 hemagglutinin-esterase-fusion_g_4 1767_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48887 hemagglutinin-esterase-fusion_g_5 1768_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48888 hemagglutinin-esterase-fusion_g_1 1768_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48889 hemagglutinin-esterase-fusion_g_2 1768_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48890 hemagglutinin-esterase-fusion_g_3 1768_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48891 hemagglutinin-esterase-fusion_g_4 1768_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48892 hemagglutinin-esterase-fusion_g_5 1769_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48893 hemagglutinin-esterase-fusion_g_1 1769_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48894 hemagglutinin-esterase-fusion_g_2 1769_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48895 hemagglutinin-esterase-fusion_g_3 1769_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48896 hemagglutinin-esterase-fusion_g_4 1769_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48897 hemagglutinin-esterase-fusion_g_5 1770_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48898 hemagglutinin-esterase-fusion_g_1 1770_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48899 hemagglutinin-esterase-fusion_g_2 1770_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48900 hemagglutinin-esterase-fusion_g_3 1770_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48901 hemagglutinin-esterase-fusion_g_4 1770_Influenza_C_virus_(C/Ann_Arbor/1/50)_HEF_gene_for_(—) 48902 hemagglutinin-esterase-fusion_g_5 1771_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48903 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_1 1771_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48904 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_2 1771_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48905 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_3 1771_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48906 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_4 1771_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48907 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_5 1772_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48908 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_1 1772_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48909 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_2 1772_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48910 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_3 1772_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48911 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_4 1772_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_7_(—) 48912 matrix_protein_2_(M2)_and_matrix_protein_1_(M1)_genes_g_5 1773_Human_papillomavirus_type_92_g_1 48913 1773_Human_papillomavirus_type_92_g_2 48914 1773_Human_papillomavirus_type_92_g_3 48915 1773_Human_papillomavirus_type_92_g_4 48916 1773_Human_papillomavirus_type_92_g_5 48917 1774_Human_papillomavirus_type_92_g_1 48918 1774_Human_papillomavirus_type_92_g_2 48919 1774_Human_papillomavirus_type_92_g_3 48920 1774_Human_papillomavirus_type_92_g_4 48921 1774_Human_papillomavirus_type_92_g_5 48922 1775_Human_papillomavirus_type_92_g_1 48923 1775_Human_papillomavirus_type_92_g_2 48924 1775_Human_papillomavirus_type_92_g_3 48925 1775_Human_papillomavirus_type_92_g_4 48926 1775_Human_papillomavirus_type_92_g_5 48927 1776_Human_papillomavirus_type_92_g_1 48928 1776_Human_papillomavirus_type_92_g_2 48929 1776_Human_papillomavirus_type_92_g_3 48930 1776_Human_papillomavirus_type_92_g_4 48931 1776_Human_papillomavirus_type_92_g_5 48932 1777_Human_papillomavirus_type_92_g_1 48933 1777_Human_papillomavirus_type_92_g_2 48934 1777_Human_papillomavirus_type_92_g_3 48935 1777_Human_papillomavirus_type_92_g_4 48936 1777_Human_papillomavirus_type_92_g_5 48937 1778_Human_papillomavirus_type_92_g_1 48938 1778_Human_papillomavirus_type_92_g_2 48939 1778_Human_papillomavirus_type_92_g_3 48940 1778_Human_papillomavirus_type_92_g_4 48941 1778_Human_papillomavirus_type_92_g_5 48942 1779_Human_papillomavirus_type_92_g_1 48943 1779_Human_papillomavirus_type_92_g_2 48944 1779_Human_papillomavirus_type_92_g_3 48945 1779_Human_papillomavirus_type_92_g_4 48946 1779_Human_papillomavirus_type_92_g_5 48947 1780_Human_papillomavirus_type_92_g_1 48948 1780_Human_papillomavirus_type_92_g_2 48949 1780_Human_papillomavirus_type_92_g_3 48950 1780_Human_papillomavirus_type_92_g_4 48951 1780_Human_papillomavirus_type_92_g_5 48952 1781_Human_papillomavirus_type_92_g_1 48953 1781_Human_papillomavirus_type_92_g_2 48954 1781_Human_papillomavirus_type_92_g_3 48955 1781_Human_papillomavirus_type_92_g_4 48956 1781_Human_papillomavirus_type_92_g_5 48957 1782_Human_papillomavirus_type_92_g_1 48958 1782_Human_papillomavirus_type_92_g_2 48959 1782_Human_papillomavirus_type_92_g_3 48960 1782_Human_papillomavirus_type_92_g_4 48961 1782_Human_papillomavirus_type_92_g_5 48962 1783_Human_papillomavirus_type_92_g_1 48963 1783_Human_papillomavirus_type_92_g_2 48964 1783_Human_papillomavirus_type_92_g_3 48965 1783_Human_papillomavirus_type_92_g_4 48966 1783_Human_papillomavirus_type_92_g_5 48967 1784_Human_papillomavirus_type_92_g_1 48968 1784_Human_papillomavirus_type_92_g_2 48969 1784_Human_papillomavirus_type_92_g_3 48970 1784_Human_papillomavirus_type_92_g_4 48971 1784_Human_papillomavirus_type_92_g_5 48972 1785_Human_papillomavirus_type_92_g_1 48973 1785_Human_papillomavirus_type_92_g_2 48974 1785_Human_papillomavirus_type_92_g_3 48975 1785_Human_papillomavirus_type_92_g_4 48976 1785_Human_papillomavirus_type_92_g_5 48977 1786_Human_papillomavirus_type_92_g_1 48978 1786_Human_papillomavirus_type_92_g_2 48979 1786_Human_papillomavirus_type_92_g_3 48980 1786_Human_papillomavirus_type_92_g_4 48981 1786_Human_papillomavirus_type_92_g_5 48982 1787_Human_papillomavirus_type_92_g_1 48983 1787_Human_papillomavirus_type_92_g_2 48984 1787_Human_papillomavirus_type_92_g_3 48985 1787_Human_papillomavirus_type_92_g_4 48986 1787_Human_papillomavirus_type_92_g_5 48987 1788_Human_papillomavirus_type_92_g_1 48988 1788_Human_papillomavirus_type_92_g_2 48989 1788_Human_papillomavirus_type_92_g_3 48990 1788_Human_papillomavirus_type_92_g_4 48991 1788_Human_papillomavirus_type_92_g_5 48992 1789_Human_papillomavirus_type_92_g_1 48993 1789_Human_papillomavirus_type_92_g_2 48994 1789_Human_papillomavirus_type_92_g_3 48995 1789_Human_papillomavirus_type_92_g_4 48996 1789_Human_papillomavirus_type_92_g_5 48997 1790_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 48998 1790_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 48999 1790_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49000 1790_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49001 1790_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49002 1791_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49003 1791_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49004 1791_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49005 1791_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49006 1791_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49007 1792_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49008 1792_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49009 1792_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49010 1792_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49011 1792_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49012 1793_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49013 1793_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49014 1793_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49015 1793_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49016 1793_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49017 1794_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49018 1794_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49019 1794_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49020 1794_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49021 1794_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49022 1795_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49023 1795_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49024 1795_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49025 1795_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49026 1795_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49027 1796_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49028 1796_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49029 1796_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49030 1796_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49031 1796_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49032 1797_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49033 1797_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49034 1797_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49035 1797_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49036 1797_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49037 1798_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49038 1798_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49039 1798_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49040 1798_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49041 1798_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49042 1799_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49043 1799_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49044 1799_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49045 1799_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49046 1799_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49047 1800_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49048 1800_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49049 1800_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49050 1800_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49051 1800_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49052 1801_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49053 1801_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49054 1801_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49055 1801_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49056 1801_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49057 1802_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49058 1802_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49059 1802_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49060 1802_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49061 1802_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49062 1803_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49063 1803_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49064 1803_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49065 1803_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49066 1803_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49067 1804_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49068 1804_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49069 1804_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49070 1804_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49071 1804_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49072 1805_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49073 1805_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49074 1805_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49075 1805_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49076 1805_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49077 1806_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49078 1806_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49079 1806_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49080 1806_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49081 1806_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49082 1807_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49083 1807_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49084 1807_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49085 1807_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49086 1807_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49087 1808_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49088 1808_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49089 1808_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49090 1808_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49091 1808_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49092 1809_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49093 1809_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49094 1809_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49095 1809_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49096 1809_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49097 1810_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49098 1810_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49099 1810_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49100 1810_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49101 1810_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49102 1811_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49103 1811_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49104 1811_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49105 1811_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49106 1811_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49107 1812_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49108 1812_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49109 1812_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49110 1812_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49111 1812_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49112 1813_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49113 1813_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49114 1813_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49115 1813_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49116 1813_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49117 1814_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49118 1814_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49119 1814_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49120 1814_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49121 1814_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49122 1815_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49123 1815_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49124 1815_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49125 1815_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49126 1815_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49127 1816_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49128 1816_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49129 1816_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49130 1816_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49131 1816_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49132 1817_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49133 1817_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49134 1817_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49135 1817_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49136 1817_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49137 1818_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49138 1818_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49139 1818_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49140 1818_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49141 1818_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49142 1819_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49143 1819_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49144 1819_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49145 1819_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49146 1819_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49147 1820_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49148 1820_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49149 1820_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49150 1820_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49151 1820_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49152 1821_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49153 1821_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49154 1821_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49155 1821_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49156 1821_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49157 1822_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49158 1822_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49159 1822_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49160 1822_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49161 1822_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49162 1823_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49163 1823_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49164 1823_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49165 1823_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49166 1823_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49167 1824_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49168 1824_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49169 1824_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49170 1824_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49171 1824_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49172 1825_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49173 1825_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49174 1825_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49175 1825_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49176 1825_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49177 1826_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49178 1826_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49179 1826_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49180 1826_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49181 1826_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49182 1827_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49183 1827_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49184 1827_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49185 1827_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49186 1827_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49187 1828_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49188 1828_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49189 1828_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49190 1828_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49191 1828_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49192 1829_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49193 1829_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49194 1829_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49195 1829_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49196 1829_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49197 1830_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49198 1830_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49199 1830_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49200 1830_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49201 1830_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49202 1831_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49203 1831_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49204 1831_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49205 1831_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49206 1831_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49207 1832_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49208 1832_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49209 1832_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49210 1832_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49211 1832_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49212 1833_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49213 1833_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49214 1833_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49215 1833_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49216 1833_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49217 1834_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49218 1834_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49219 1834_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49220 1834_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49221 1834_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49222 1835_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49223 1835_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49224 1835_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49225 1835_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49226 1835_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49227 1836_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49228 1836_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49229 1836_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49230 1836_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49231 1836_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49232 1837_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49233 1837_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49234 1837_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49235 1837_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49236 1837_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49237 1838_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49238 1838_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49239 1838_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49240 1838_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49241 1838_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49242 1839_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49243 1839_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49244 1839_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49245 1839_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49246 1839_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49247 1840_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49248 1840_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49249 1840_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49250 1840_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49251 1840_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49252 1841_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49253 1841_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49254 1841_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49255 1841_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49256 1841_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49257 1842_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49258 1842_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49259 1842_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49260 1842_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49261 1842_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49262 1843_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49263 1843_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49264 1843_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49265 1843_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49266 1843_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49267 1844_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49268 1844_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49269 1844_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49270 1844_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49271 1844_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49272 1845_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49273 1845_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49274 1845_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49275 1845_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49276 1845_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49277 1846_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49278 1846_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49279 1846_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49280 1846_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49281 1846_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49282 1847_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49283 1847_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49284 1847_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49285 1847_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49286 1847_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49287 1848_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49288 1848_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49289 1848_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49290 1848_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49291 1848_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49292 1849_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49293 1849_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49294 1849_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49295 1849_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49296 1849_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49297 1850_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49298 1850_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49299 1850_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49300 1850_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49301 1850_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49302 1851_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49303 1851_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49304 1851_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49305 1851_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49306 1851_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49307 1852_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49308 1852_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49309 1852_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49310 1852_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49311 1852_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49312 1853_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49313 1853_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49314 1853_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49315 1853_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49316 1853_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49317 1854_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49318 1854_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49319 1854_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49320 1854_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49321 1854_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49322 1855_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49323 1855_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49324 1855_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49325 1855_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49326 1855_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49327 1856_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49328 1856_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49329 1856_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49330 1856_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49331 1856_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49332 1857_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49333 1857_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49334 1857_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49335 1857_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49336 1857_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49337 1858_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49338 1858_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49339 1858_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49340 1858_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49341 1858_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49342 1859_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49343 1859_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49344 1859_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49345 1859_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49346 1859_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49347 1860_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49348 1860_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49349 1860_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49350 1860_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49351 1860_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49352 1861_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49353 1861_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49354 1861_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49355 1861_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49356 1861_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49357 1862_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49358 1862_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49359 1862_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49360 1862_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49361 1862_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49362 1863_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49363 1863_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49364 1863_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49365 1863_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49366 1864_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49367 1864_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49368 1864_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49369 1864_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49370 1864_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49371 1865_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49372 1865_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49373 1865_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49374 1865_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49375 1865_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49376 1866_Human_coronavirus_OC43_strain_ATCC_VR-759_g_1 49377 1866_Human_coronavirus_OC43_strain_ATCC_VR-759_g_2 49378 1866_Human_coronavirus_OC43_strain_ATCC_VR-759_g_3 49379 1866_Human_coronavirus_OC43_strain_ATCC_VR-759_g_4 49380 1866_Human_coronavirus_OC43_strain_ATCC_VR-759_g_5 49381 1867_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49382 segment_8_g_1 1867_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49383 segment_8_g_2 1867_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49384 segment_8_g_3 1867_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49385 segment_8_g_4 1867_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49386 segment_8_g_5 1868_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49387 segment_8_g_1 1868_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49388 segment_8_g_2 1868_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49389 segment_8_g_3 1868_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49390 segment_8_g_4 1868_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 49391 segment_8_g_5 1869_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49392 segment_8_g_1 1869_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49393 segment_8_g_2 1869_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49394 segment_8_g_3 1869_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49395 segment_8_g_4 1869_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49396 segment_8_g_5 1870_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49397 segment_8_g_1 1870_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49398 segment_8_g_2 1870_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49399 segment_8_g_3 1870_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49400 segment_8_g_4 1870_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49401 segment_8_g_5 1871_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49402 segment_8_g_1 1871_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49403 segment_8_g_2 1871_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49404 segment_8_g_3 1871_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49405 segment_8_g_4 1871_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 49406 segment_8_g_5 1872_Hepatitis_C_virus_genotype_3_g_1 49407 1872_Hepatitis_C_virus_genotype_3_g_2 49408 1872_Hepatitis_C_virus_genotype_3_g_3 49409 1872_Hepatitis_C_virus_genotype_3_g_4 49410 1872_Hepatitis_C_virus_genotype_3_g_5 49411 1873_Hepatitis_C_virus_genotype_3_g_1 49412 1873_Hepatitis_C_virus_genotype_3_g_2 49413 1873_Hepatitis_C_virus_genotype_3_g_3 49414 1874_Hepatitis_C_virus_genotype_3_g_1 49415 1874_Hepatitis_C_virus_genotype_3_g_2 49416 1874_Hepatitis_C_virus_genotype_3_g_3 49417 1874_Hepatitis_C_virus_genotype_3_g_4 49418 1875_Hepatitis_C_virus_genotype_3_g_1 49419 1875_Hepatitis_C_virus_genotype_3_g_2 49420 1875_Hepatitis_C_virus_genotype_3_g_3 49421 1876_Hepatitis_C_virus_genotype_3_g_1 49422 1876_Hepatitis_C_virus_genotype_3_g_2 49423 1876_Hepatitis_C_virus_genotype_3_g_3 49424 1876_Hepatitis_C_virus_genotype_3_g_4 49425 1876_Hepatitis_C_virus_genotype_3_g_5 49426 1877_Hepatitis_C_virus_genotype_3_g_1 49427 1877_Hepatitis_C_virus_genotype_3_g_2 49428 1877_Hepatitis_C_virus_genotype_3_g_3 49429 1877_Hepatitis_C_virus_genotype_3_g_4 49430 1877_Hepatitis_C_virus_genotype_3_g_5 49431 1878_Hepatitis_C_virus_genotype_3_g_1 49432 1878_Hepatitis_C_virus_genotype_3_g_2 49433 1878_Hepatitis_C_virus_genotype_3_g_3 49434 1878_Hepatitis_C_virus_genotype_3_g_4 49435 1878_Hepatitis_C_virus_genotype_3_g_5 49436 1879_Hepatitis_C_virus_genotype_3_g_1 49437 1879_Hepatitis_C_virus_genotype_3_g_2 49438 1879_Hepatitis_C_virus_genotype_3_g_3 49439 1879_Hepatitis_C_virus_genotype_3_g_4 49440 1880_Hepatitis_C_virus_genotype_3_g_1 49441 1880_Hepatitis_C_virus_genotype_3_g_2 49442 1880_Hepatitis_C_virus_genotype_3_g_3 49443 1881_Hepatitis_C_virus_genotype_3_g_1 49444 1881_Hepatitis_C_virus_genotype_3_g_2 49445 1881_Hepatitis_C_virus_genotype_3_g_3 49446 1881_Hepatitis_C_virus_genotype_3_g_4 49447 1881_Hepatitis_C_virus_genotype_3_g_5 49448 1882_Hepatitis_C_virus_genotype_3_g_1 49449 1882_Hepatitis_C_virus_genotype_3_g_2 49450 1882_Hepatitis_C_virus_genotype_3_g_3 49451 1882_Hepatitis_C_virus_genotype_3_g_4 49452 1882_Hepatitis_C_virus_genotype_3_g_5 49453 1883_Hepatitis_C_virus_genotype_3_g_1 49454 1883_Hepatitis_C_virus_genotype_3_g_2 49455 1883_Hepatitis_C_virus_genotype_3_g_3 49456 1883_Hepatitis_C_virus_genotype_3_g_4 49457 1883_Hepatitis_C_virus_genotype_3_g_5 49458 1884_Hepatitis_C_virus_genotype_3_g_1 49459 1884_Hepatitis_C_virus_genotype_3_g_2 49460 1884_Hepatitis_C_virus_genotype_3_g_3 49461 1884_Hepatitis_C_virus_genotype_3_g_4 49462 1884_Hepatitis_C_virus_genotype_3_g_5 49463 1885_Hepatitis_C_virus_genotype_3_g_1 49464 1885_Hepatitis_C_virus_genotype_3_g_2 49465 1885_Hepatitis_C_virus_genotype_3_g_3 49466 1885_Hepatitis_C_virus_genotype_3_g_4 49467 1885_Hepatitis_C_virus_genotype_3_g_5 49468 1886_Hepatitis_C_virus_genotype_3_g_1 49469 1886_Hepatitis_C_virus_genotype_3_g_2 49470 1886_Hepatitis_C_virus_genotype_3_g_3 49471 1886_Hepatitis_C_virus_genotype_3_g_4 49472 1886_Hepatitis_C_virus_genotype_3_g_5 49473 1887_Hepatitis_C_virus_genotype_3_g_1 49474 1887_Hepatitis_C_virus_genotype_3_g_2 49475 1887_Hepatitis_C_virus_genotype_3_g_3 49476 1887_Hepatitis_C_virus_genotype_3_g_4 49477 1887_Hepatitis_C_virus_genotype_3_g_5 49478 1888_Hepatitis_C_virus_genotype_3_g_1 49479 1888_Hepatitis_C_virus_genotype_3_g_2 49480 1888_Hepatitis_C_virus_genotype_3_g_3 49481 1888_Hepatitis_C_virus_genotype_3_g_4 49482 1888_Hepatitis_C_virus_genotype_3_g_5 49483 1889_Hepatitis_C_virus_genotype_3_g_1 49484 1890_Hepatitis_C_virus_genotype_3_g_1 49485 1890_Hepatitis_C_virus_genotype_3_g_2 49486 1890_Hepatitis_C_virus_genotype_3_g_3 49487 1890_Hepatitis_C_virus_genotype_3_g_4 49488 1890_Hepatitis_C_virus_genotype_3_g_5 49489 1891_Hepatitis_C_virus_genotype_3_g_1 49490 1891_Hepatitis_C_virus_genotype_3_g_2 49491 1891_Hepatitis_C_virus_genotype_3_g_3 49492 1891_Hepatitis_C_virus_genotype_3_g_4 49493 1891_Hepatitis_C_virus_genotype_3_g_5 49494 1892_Hepatitis_C_virus_genotype_3_g_1 49495 1892_Hepatitis_C_virus_genotype_3_g_2 49496 1892_Hepatitis_C_virus_genotype_3_g_3 49497 1892_Hepatitis_C_virus_genotype_3_g_4 49498 1893_Hepatitis_C_virus_genotype_3_g_1 49499 1893_Hepatitis_C_virus_genotype_3_g_2 49500 1893_Hepatitis_C_virus_genotype_3_g_3 49501 1893_Hepatitis_C_virus_genotype_3_g_4 49502 1893_Hepatitis_C_virus_genotype_3_g_5 49503 1894_Hepatitis_C_virus_genotype_3_g_1 49504 1894_Hepatitis_C_virus_genotype_3_g_2 49505 1894_Hepatitis_C_virus_genotype_3_g_3 49506 1894_Hepatitis_C_virus_genotype_3_g_4 49507 1894_Hepatitis_C_virus_genotype_3_g_5 49508 1895_Hepatitis_C_virus_genotype_3_g_1 49509 1895_Hepatitis_C_virus_genotype_3_g_2 49510 1895_Hepatitis_C_virus_genotype_3_g_3 49511 1895_Hepatitis_C_virus_genotype_3_g_4 49512 1895_Hepatitis_C_virus_genotype_3_g_5 49513 1896_Hepatitis_C_virus_genotype_3_g_1 49514 1896_Hepatitis_C_virus_genotype_3_g_2 49515 1896_Hepatitis_C_virus_genotype_3_g_3 49516 1896_Hepatitis_C_virus_genotype_3_g_4 49517 1896_Hepatitis_C_virus_genotype_3_g_5 49518 1897_Hepatitis_C_virus_genotype_3_g_1 49519 1897_Hepatitis_C_virus_genotype_3_g_2 49520 1897_Hepatitis_C_virus_genotype_3_g_3 49521 1897_Hepatitis_C_virus_genotype_3_g_4 49522 1897_Hepatitis_C_virus_genotype_3_g_5 49523 1898_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49524 segment_1_g_1 1898_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49525 segment_1_g_2 1898_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49526 segment_1_g_3 1898_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49527 segment_1_g_4 1898_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49528 segment_1_g_5 1899_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49529 segment_1_g_1 1899_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49530 segment_1_g_2 1899_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49531 segment_1_g_3 1899_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49532 segment_1_g_4 1899_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49533 segment_1_g_5 1900_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49534 segment_1_g_1 1900_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49535 segment_1_g_2 1900_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49536 segment_1_g_3 1900_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49537 segment_1_g_4 1900_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49538 segment_1_g_5 1901_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49539 segment_1_g_1 1901_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49540 segment_1_g_2 1901_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49541 segment_1_g_3 1901_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49542 segment_1_g_4 1901_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49543 segment_1_g_5 1902_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49544 segment_1_g_1 1902_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49545 segment_1_g_2 1902_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49546 segment_1_g_3 1902_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49547 segment_1_g_4 1902_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49548 segment_1_g_5 1903_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49549 segment_1_g_1 1903_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49550 segment_1_g_2 1903_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49551 segment_1_g_3 1903_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49552 segment_1_g_4 1903_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49553 segment_1_g_5 1904_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49554 segment_1_g_(—) 1904_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49555 segment_1_g_2 1904_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49556 segment_1_g_3 1904_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49557 segment_1_g_4 1904_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49558 segment_1_g_5 1905_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49559 segment_1_g_1 1905_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49560 segment_1_g_2 1905_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49561 segment_1_g_3 1905_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49562 segment_1_g_4 1905_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49563 segment_1_g_5 1906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49564 segment_1_g_1 1906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49565 segment_1_g_2 1906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49566 segment_1_g_3 1906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49567 segment_1_g_4 1906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 49568 segment_1_g_5 1907_Hepatitis_C_virus_genotype_1_g_1 49569 1907_Hepatitis_C_virus_genotype_1_g_2 49570 1907_Hepatitis_C_virus_genotype_1_g_3 49571 1907_Hepatitis_C_virus_genotype_1_g_4 49572 1907_Hepatitis_C_virus_genotype_1_g_5 49573 1908_Hepatitis_C_virus_genotype_1_g_1 49574 1908_Hepatitis_C_virus_genotype_1_g_2 49575 1908_Hepatitis_C_virus_genotype_1_g_3 49576 1908_Hepatitis_C_virus_genotype_1_g_4 49577 1908_Hepatitis_C_virus_genotype_1_g_5 49578 1909_Hepatitis_C_virus_genotype_1_g_1 49579 1909_Hepatitis_C_virus_genotype_1_g_2 49580 1910_Hepatitis_C_virus_genotype_1_g_1 49581 1910_Hepatitis_C_virus_genotype_1_g_2 49582 1910_Hepatitis_C_virus_genotype_1_g_3 49583 1910_Hepatitis_C_virus_genotype_1_g_4 49584 1910_Hepatitis_C_virus_genotype_1_g_5 49585 1911_Hepatitis_C_virus_genotype_1_g_1 49586 1911_Hepatitis_C_virus_genotype_1_g_2 49587 1911_Hepatitis_C_virus_genotype_1_g_3 49588 1911_Hepatitis_C_virus_genotype_1_g_4 49589 1911_Hepatitis_C_virus_genotype_1_g_5 49590 1912_Hepatitis_C_virus_genotype_1_g_1 49591 1912_Hepatitis_C_virus_genotype_1_g_2 49592 1912_Hepatitis_C_virus_genotype_1_g_3 49593 1912_Hepatitis_C_virus_genotype_1_g_4 49594 1913_Hepatitis_C_virus_genotype_1_g_1 49595 1913_Hepatitis_C_virus_genotype_1_g_2 49596 1913_Hepatitis_C_virus_genotype_1_g_3 49597 1913_Hepatitis_C_virus_genotype_1_g_4 49598 1913_Hepatitis_C_virus_genotype_1_g_5 49599 1914_Hepatitis_C_virus_genotype_1_g_1 49600 1914_Hepatitis_C_virus_genotype_1_g_2 49601 1914_Hepatitis_C_virus_genotype_1_g_3 49602 1914_Hepatitis_C_virus_genotype_1_g_4 49603 1914_Hepatitis_C_virus_genotype_1_g_5 49604 1915_Hepatitis_C_virus_genotype_1_g_1 49605 1915_Hepatitis_C_virus_genotype_1_g_2 49606 1915_Hepatitis_C_virus_genotype_1_g_3 49607 1915_Hepatitis_C_virus_genotype_1_g_4 49608 1915_Hepatitis_C_virus_genotype_1_g_5 49609 1916_Hepatitis_C_virus_genotype_1_g_1 49610 1916_Hepatitis_C_virus_genotype_1_g_2 49611 1916_Hepatitis_C_virus_genotype_1_g_3 49612 1917_Hepatitis_C_virus_genotype_1_g_1 49613 1917_Hepatitis_C_virus_genotype_1_g_2 49614 1918_Hepatitis_C_virus_genotype_1_g_1 49615 1918_Hepatitis_C_virus_genotype_1_g_2 49616 1918_Hepatitis_C_virus_genotype_1_g_3 49617 1918_Hepatitis_C_virus_genotype_1_g_4 49618 1918_Hepatitis_C_virus_genotype_1_g_5 49619 1919_Hepatitis_C_virus_genotype_1_g_1 49620 1919_Hepatitis_C_virus_genotype_1_g_2 49621 1919_Hepatitis_C_virus_genotype_1_g_3 49622 1919_Hepatitis_C_virus_genotype_1_g_4 49623 1919_Hepatitis_C_virus_genotype_1_g_5 49624 1920_Hepatitis_C_virus_genotype_1_g_1 49625 1920_Hepatitis_C_virus_genotype_1_g_2 49626 1920_Hepatitis_C_virus_genotype_1_g_3 49627 1920_Hepatitis_C_virus_genotype_1_g_4 49628 1920_Hepatitis_C_virus_genotype_1_g_5 49629 1921_Hepatitis_C_virus_genotype_1_g_1 49630 1922_Hepatitis_C_virus_genotype_1_g_1 49631 1922_Hepatitis_C_virus_genotype_1_g_2 49632 1922_Hepatitis_C_virus_genotype_1_g_3 49633 1922_Hepatitis_C_virus_genotype_1_g_4 49634 1923_Hepatitis_C_virus_genotype_1_g_1 49635 1923_Hepatitis_C_virus_genotype_1_g_2 49636 1923_Hepatitis_C_virus_genotype_1_g_3 49637 1923_Hepatitis_C_virus_genotype_1_g_4 49638 1923_Hepatitis_C_virus_genotype_1_g_3 49639 1924_Hepatitis_C_virus_genotype_1_g_1 49640 1924_Hepatitis_C_virus_genotype_1_g_2 49641 1924_Hepatitis_C_virus_genotype_1_g_3 49642 1924_Hepatitis_C_virus_genotype_1_g_4 49643 1924_Hepatitis_C_virus_genotype_1_g_3 49644 1925_Hepatitis_C_virus_genotype_1_g_1 49645 1925_Hepatitis_C_virus_genotype_1_g_2 49646 1925_Hepatitis_C_virus_genotype_1_g_3 49647 1925_Hepatitis_C_virus_genotype_1_g_4 49648 1926_Hepatitis_C_virus_genotype_1_g_1 49649 1926_Hepatitis_C_virus_genotype_1_g_2 49650 1926_Hepatitis_C_virus_genotype_1_g_3 49651 1926_Hepatitis_C_virus_genotype_1_g_4 49652 1926_Hepatitis_C_virus_genotype_1_g_5 49653 1927_Hepatitis_C_virus_genotype_1_g_1 49654 1927_Hepatitis_C_virus_genotype_1_g_2 49655 1927_Hepatitis_C_virus_genotype_1_g_3 49656 1927_Hepatitis_C_virus_genotype_1_g_4 49657 1927_Hepatitis_C_virus_genotype_1_g_5 49658 1928_Hepatitis_C_virus_genotype_1_g_1 49659 1928_Hepatitis_C_virus_genotype_1_g_2 49660 1928_Hepatitis_C_virus_genotype_1_g_3 49661 1928_Hepatitis_C_virus_genotype_1_g_4 49662 1928_Hepatitis_C_virus_genotype_1_g_5 49663 1929_Hepatitis_C_virus_genotype_1_g_1 49664 1929_Hepatitis_C_virus_genotype_1_g_2 49665 1929_Hepatitis_C_virus_genotype_1_g_3 49666 1929_Hepatitis_C_virus_genotype_1_g_4 49667 1929_Hepatitis_C_virus_genotype_1_g_5 49668 1930_Hepatitis_C_virus_genotype_1_g_1 49669 1930_Hepatitis_C_virus_genotype_1_g_2 49670 1930_Hepatitis_C_virus_genotype_1_g_3 49671 1930_Hepatitis_C_virus_genotype_1_g_4 49672 1930_Hepatitis_C_virus_genotype_1_g_5 49673 1931_Human_papillomavirus_type_10_genomic_DNA_g_1 49674 1931_Human_papillomavirus_type_10_genomic_DNA_g_2 49675 1931_Human_papillomavirus_type_10_genomic_DNA_g_3 49676 1931_Human_papillomavirus_type_10_genomic_DNA_g_4 49677 1931_Human_papillomavirus_type_10_genomic_DNA_g_5 49678 1932_Human_papillomavirus_type_10_genomic_DNA_g_1 49679 1932_Human_papillomavirus_type_10_genomic_DNA_g_2 49680 1932_Human_papillomavirus_type_10_genomic_DNA_g_3 49681 1932_Human_papillomavirus_type_10_genomic_DNA_g_4 49682 1932_Human_papillomavirus_type_10_genomic_DNA_g_5 49683 1933_Human_papillomavirus_type_10_genomic_DNA_g_1 49684 1933_Human_papillomavirus_type_10_genomic_DNA_g_2 49685 1933_Human_papillomavirus_type_10_genomic_DNA_g_3 49686 1933_Human_papillomavirus_type_10_genomic_DNA_g_4 49687 1933_Human_papillomavirus_type_10_genomic_DNA_g_5 49688 1934_Human_papillomavirus_type_10_genomic_DNA_g_1 49689 1934_Human_papillomavirus_type_10_genomic_DNA_g_2 49690 1934_Human_papillomavirus_type_10_genomic_DNA_g_3 49691 1934_Human_papillomavirus_type_10_genomic_DNA_g_4 49692 1934_Human_papillomavirus_type_10_genomic_DNA_g_5 49693 1935_Human_papillomavirus_type_10_genomic_DNA_g_1 49694 1935_Human_papillomavirus_type_10_genomic_DNA_g_2 49695 1935_Human_papillomavirus_type_10_genomic_DNA_g_3 49696 1935_Human_papillomavirus_type_10_genomic_DNA_g_4 49697 1935_Human_papillomavirus_type_10_genomic_DNA_g_5 49698 1936_Human_papillomavirus_type_10_genomic_DNA_g_1 49699 1936_Human_papillomavirus_type_10_genomic_DNA_g_2 49700 1936_Human_papillomavirus_type_10_genomic_DNA_g_3 49701 1936_Human_papillomavirus_type_10_genomic_DNA_g_4 49702 1936_Human_papillomavirus_type_10_genomic_DNA_g_5 49703 1937_Human_papillomavirus_type_10_genomic_DNA_g_1 49704 1937_Human_papillomavirus_type_10_genomic_DNA_g_2 49705 1937_Human_papillomavirus_type_10_genomic_DNA_g_3 49706 1937_Human_papillomavirus_type_10_genomic_DNA_g_4 49707 1937_Human_papillomavirus_type_10_genomic_DNA_g_5 49708 1938_Human_papillomavirus_type_10_genomic_DNA_g_1 49709 1938_Human_papillomavirus_type_10_genomic_DNA_g_2 49710 1938_Human_papillomavirus_type_10_genomic_DNA_g_3 49711 1938_Human_papillomavirus_type_10_genomic_DNA_g_4 49712 1938_Human_papillomavirus_type_10_genomic_DNA_g_5 49713 1939_Human_papillomavirus_type_10_genomic_DNA_g_1 49714 1939_Human_papillomavirus_type_10_genomic_DNA_g_2 49715 1939_Human_papillomavirus_type_10_genomic_DNA_g_3 49716 1939_Human_papillomavirus_type_10_genomic_DNA_g_4 49717 1939_Human_papillomavirus_type_10_genomic_DNA_g_5 49718 1940_Human_papillomavirus_type_10_genomic_DNA_g_1 49719 1940_Human_papillomavirus_type_10_genomic_DNA_g_2 49720 1940_Human_papillomavirus_type_10_genomic_DNA_g_3 49721 1940_Human_papillomavirus_type_10_genomic_DNA_g_4 49722 1940_Human_papillomavirus_type_10_genomic_DNA_g_5 49723 1941_Human_papillomavirus_type_10_genomic_DNA_g_1 49724 1941_Human_papillomavirus_type_10_genomic_DNA_g_2 49725 1941_Human_papillomavirus_type_10_genomic_DNA_g_3 49726 1941_Human_papillomavirus_type_10_genomic_DNA_g_4 49727 1941_Human_papillomavirus_type_10_genomic_DNA_g_5 49728 1942_Human_papillomavirus_type_10_genomic_DNA_g_1 49729 1942_Human_papillomavirus_type_10_genomic_DNA_g_2 49730 1942_Human_papillomavirus_type_10_genomic_DNA_g_3 49731 1942_Human_papillomavirus_type_10_genomic_DNA_g_4 49732 1942_Human_papillomavirus_type_10_genomic_DNA_g_5 49733 1943_Human_papillomavirus_type_10_genomic_DNA_g_1 49734 1943_Human_papillomavirus_type_10_genomic_DNA_g_2 49735 1943_Human_papillomavirus_type_10_genomic_DNA_g_3 49736 1943_Human_papillomavirus_type_10_genomic_DNA_g_4 49737 1943_Human_papillomavirus_type_10_genomic_DNA_g_5 49738 1944_Human_papillomavirus_type_10_genomic_DNA_g_1 49739 1944_Human_papillomavirus_type_10_genomic_DNA_g_2 49740 1944_Human_papillomavirus_type_10_genomic_DNA_g_3 49741 1944_Human_papillomavirus_type_10_genomic_DNA_g_4 49742 1944_Human_papillomavirus_type_10_genomic_DNA_g_5 49743 1945_Human_papillomavirus_type_10_genomic_DNA_g_1 49744 1945_Human_papillomavirus_type_10_genomic_DNA_g_2 49745 1945_Human_papillomavirus_type_10_genomic_DNA_g_3 49746 1945_Human_papillomavirus_type_10_genomic_DNA_g_4 49747 1945_Human_papillomavirus_type_10_genomic_DNA_g_5 49748 1946_Human_papillomavirus_type_10_genomic_DNA_g_1 49749 1946_Human_papillomavirus_type_10_genomic_DNA_g_2 49750 1946_Human_papillomavirus_type_10_genomic_DNA_g_3 49751 1946_Human_papillomavirus_type_10_genomic_DNA_g_4 49752 1946_Human_papillomavirus_type_10_genomic_DNA_g_5 49753 1947_Human_papillomavirus_type_10_genomic_DNA_g_1 49754 1947_Human_papillomavirus_type_10_genomic_DNA_g_2 49755 1947_Human_papillomavirus_type_10_genomic_DNA_g_3 49756 1947_Human_papillomavirus_type_10_genomic_DNA_g_4 49757 1947_Human_papillomavirus_type_10_genomic_DNA_g_5 49758 1948_Human_papillomavirus_type_184_complete_genome_g_1 49759 1948_Human_papillomavirus_type_184_complete_genome_g_2 49760 1948_Human_papillomavirus_type_184_complete_genome_g_3 49761 1948_Human_papillomavirus_type_184_complete_genome_g_4 49762 1948_Human_papillomavirus_type_184_complete_genome_g_5 49763 1949_Human_papillomavirus_type_184_complete_genome_g_1 49764 1949_Human_papillomavirus_type_184_complete_genome_g_2 49765 1949_Human_papillomavirus_type_184_complete_genome_g_3 49766 1949_Human_papillomavirus_type_184_complete_genome_g_4 49767 1949_Human_papillomavirus_type_184_complete_genome_g_5 49768 1950_Human_papillomavirus_type_184_complete_genome_g_1 49769 1950_Human_papillomavirus_type_184_complete_genome_g_2 49770 1950_Human_papillomavirus_type_184_complete_genome_g_3 49771 1950_Human_papillomavirus_type_184_complete_genome_g_4 49772 1950_Human_papillomavirus_type_184_complete_genome_g_5 49773 1951_Human_papillomavirus_type_184_complete_genome_g_1 49774 1951_Human_papillomavirus_type_184_complete_genome_g_2 49775 1951_Human_papillomavirus_type_184_complete_genome_g_3 49776 1951_Human_papillomavirus_type_184_complete_genome_g_4 49777 1951_Human_papillomavirus_type_184_complete_genome_g_5 49778 1952_Human_papillomavirus_type_184_complete_genome_g_1 49779 1952_Human_papillomavirus_type_184_complete_genome_g_2 49780 1952_Human_papillomavirus_type_184_complete_genome_g_3 49781 1952_Human_papillomavirus_type_184_complete_genome_g_4 49782 1952_Human_papillomavirus_type_184_complete_genome_g_5 49783 1953_Human_papillomavirus_type_184_complete_genome_g_1 49784 1953_Human_papillomavirus_type_184_complete_genome_g_2 49785 1953_Human_papillomavirus_type_184_complete_genome_g_3 49786 1953_Human_papillomavirus_type_184_complete_genome_g_4 49787 1953_Human_papillomavirus_type_184_complete_genome_g_5 49788 1954_Human_papillomavirus_type_184_complete_genome_g_1 49789 1954_Human_papillomavirus_type_184_complete_genome_g_2 49790 1954_Human_papillomavirus_type_184_complete_genome_g_3 49791 1954_Human_papillomavirus_type_184_complete_genome_g_4 49792 1954_Human_papillomavirus_type_184_complete_genome_g_5 49793 1955_Human_papillomavirus_type_184_complete_genome_g_1 49794 1955_Human_papillomavirus_type_184_complete_genome_g_2 49795 1955_Human_papillomavirus_type_184_complete_genome_g_3 49796 1955_Human_papillomavirus_type_184_complete_genome_g_4 49797 1955_Human_papillomavirus_type_184_complete_genome_g_5 49798 1956_Human_papillomavirus_type_184_complete_genome_g_1 49799 1956_Human_papillomavirus_type_184_complete_genome_g_2 49800 1956_Human_papillomavirus_type_184_complete_genome_g_3 49801 1956_Human_papillomavirus_type_184_complete_genome_g_4 49802 1956_Human_papillomavirus_type_184_complete_genome_g_5 49803 1957_Human_papillomavirus_type_184_complete_genome_g_1 49804 1957_Human_papillomavirus_type_184_complete_genome_g_2 49805 1957_Human_papillomavirus_type_184_complete_genome_g_3 49806 1957_Human_papillomavirus_type_184_complete_genome_g_4 49807 1957_Human_papillomavirus_type_184_complete_genome_g_5 49808 1958_Human_papillomavirus_type_184_complete_genome_g_1 49809 1958_Human_papillomavirus_type_184_complete_genome_g_2 49810 1958_Human_papillomavirus_type_184_complete_genome_g_3 49811 1958_Human_papillomavirus_type_184_complete_genome_g_4 49812 1958_Human_papillomavirus_type_184_complete_genome_g_5 49813 1959_Human_papillomavirus_type_184_complete_genome_g_1 49814 1959_Human_papillomavirus_type_184_complete_genome_g_2 49815 1959_Human_papillomavirus_type_184_complete_genome_g_3 49816 1959_Human_papillomavirus_type_184_complete_genome_g_4 49817 1959_Human_papillomavirus_type_184_complete_genome_g_5 49818 1960_Human_papillomavirus_type_184_complete_genome_g_1 49819 1960_Human_papillomavirus_type_184_complete_genome_g_2 49820 1960_Human_papillomavirus_type_184_complete_genome_g_3 49821 1960_Human_papillomavirus_type_184_complete_genome_g_4 49822 1960_Human_papillomavirus_type_184_complete_genome_g_5 49823 1961_Human_papillomavirus_type_184_complete_genome_g_1 49824 1961_Human_papillomavirus_type_184_complete_genome_g_2 49825 1961_Human_papillomavirus_type_184_complete_genome_g_3 49826 1961_Human_papillomavirus_type_184_complete_genome_g_4 49827 1961_Human_papillomavirus_type_184_complete_genome_g_5 49828 1962_Influenza_B_virus_(B/Lee/1940)_segment_2_g_1 49829 1962_Influenza_B_virus_(B/Lee/1940)_segment_2_g_2 49830 1962_Influenza_B_virus_(B/Lee/1940)_segment_2_g_3 49831 1962_Influenza_B_virus_(B/Lee/1940)_segment_2_g_4 49832 1962_Influenza_B_virus_(B/Lee/1940)_segment_2_g_5 49833 1963_Influenza_B_virus_(B/Lee/1940)_segment_2_g_1 49834 1963_Influenza_B_virus_(B/Lee/1940)_segment_2_g_2 49835 1963_Influenza_B_virus_(B/Lee/1940)_segment_2_g_3 49836 1963_Influenza_B_virus_(B/Lee/1940)_segment_2_g_4 49837 1963_Influenza_B_virus_(B/Lee/1940)_segment_2_g_5 49838 1964_Influenza_B_virus_(B/Lee/1940)_segment_2_g_1 49839 1964_Influenza_B_virus_(B/Lee/1940)_segment_2_g_2 49840 1964_Influenza_B_virus_(B/Lee/1940)_segment_2_g_3 49841 1964_Influenza_B_virus_(B/Lee/1940)_segment_2_g_4 49842 1964_Influenza_B_virus_(B/Lee/1940)_segment_2_g_5 49843 1965_Influenza_B_virus_(B/Lee/1940)_segment_2_g_1 49844 1965_Influenza_B_virus_(B/Lee/1940)_segment_2_g_2 49845 1965_Influenza_B_virus_(B/Lee/1940)_segment_2_g_3 49846 1965_Influenza_B_virus_(B/Lee/1940)_segment_2_g_4 49847 1965_Influenza_B_virus_(B/Lee/1940)_segment_2_g_5 49848 1966_Influenza_B_virus_(B/Lee/1940)_segment_2_g_1 49849 1966_Influenza_B_virus_(B/Lee/1940)_segment_2_g_2 49850 1966_Influenza_B_virus_(B/Lee/1940)_segment_2_g_3 49851 1966_Influenza_B_virus_(B/Lee/1940)_segment_2_g_4 49852 1966_Influenza_B_virus_(B/Lee/1940)_segment_2_g_5 49853 1967_Influenza_B_virus_(B/Lee/1940)_segment_2_g_1 49854 1967_Influenza_B_virus_(B/Lee/1940)_segment_2_g_2 49855 1967_Influenza_B_virus_(B/Lee/1940)_segment_2_g_3 49856 1967_Influenza_B_virus_(B/Lee/1940)_segment_2_g_4 49857 1967_Influenza_B_virus_(B/Lee/1940)_segment_2_g_5 49858 1968_Influenza_B_virus_(B/Lee/1940)_segment_2_g_1 49859 1968_Influenza_B_virus_(B/Lee/1940)_segment_2_g_2 49860 1968_Influenza_B_virus_(B/Lee/1940)_segment_2_g_3 49861 1968_Influenza_B_virus_(B/Lee/1940)_segment_2_g_4 49862 1968_Influenza_B_virus_(B/Lee/1940)_segment_2_g_5 49863 1969_Influenza_B_virus_(B/Lee/1940)_segment_2_g_1 49864 1969_Influenza_B_virus_(B/Lee/1940)_segment_2_g_2 49865 1969_Influenza_B_virus_(B/Lee/1940)_segment_2_g_3 49866 1969_Influenza_B_virus_(B/Lee/1940)_segment_2_g_4 49867 1969_Influenza_B_virus_(B/Lee/1940)_segment_2_g_5 49868 1970_Influenza_B_virus_(B/Lee/1940)_segment_2_g_1 49869 1970_Influenza_B_virus_(B/Lee/1940)_segment_2_g_2 49870 1970_Influenza_B_virus_(B/Lee/1940)_segment_2_g_3 49871 1970_Influenza_B_virus_(B/Lee/1940)_segment_2_g_4 49872 1970_Influenza_B_virus_(B/Lee/1940)_segment_2_g_5 49873 1971_Human_coronavirus_HKU1_g_1 49874 1971_Human_coronavirus_HKU1_g_2 49875 1971_Human_coronavirus_HKU1_g_3 49876 1971_Human_coronavirus_HKU1_g_4 49877 1971_Human_coronavirus_HKU1_g_5 49878 1972_Human_coronavirus_HKU1_g_1 49879 1972_Human_coronavirus_HKU1_g_2 49880 1972_Human_coronavirus_HKU1_g_3 49881 1972_Human_coronavirus_HKU1_g_4 49882 1972_Human_coronavirus_HKU1_g_5 49883 1973_Human_coronavirus_HKU1_g_1 49884 1973_Human_coronavirus_HKU1_g_2 49885 1973_Human_coronavirus_HKU1_g_3 49886 1973_Human_coronavirus_HKU1_g_4 49887 1973_Human_coronavirus_HKU1_g_5 49888 1974_Human_coronavirus_HKU1_g_1 49889 1974_Human_coronavirus_HKU1_g_2 49890 1974_Human_coronavirus_HKU1_g_3 49891 1974_Human_coronavirus_HKU1_g_4 49892 1974_Human_coronavirus_HKU1_g_5 49893 1975_Human_coronavirus_HKU1_g_1 49894 1975_Human_coronavirus_HKU1_g_2 49895 1975_Human_coronavirus_HKU1_g_3 49896 1975_Human_coronavirus_HKU1_g_4 49897 1975_Human_coronavirus_HKU1_g_5 49898 1976_Human_coronavirus_HKU1_g_1 49899 1976_Human_coronavirus_HKU1_g_2 49900 1976_Human_coronavirus_HKU1_g_3 49901 1976_Human_coronavirus_HKU1_g_4 49902 1976_Human_coronavirus_HKU1_g_5 49903 1977_Human_coronavirus_HKU1_g_1 49904 1977_Human_coronavirus_HKU1_g_2 49905 1977_Human_coronavirus_HKU1_g_3 49906 1977_Human_coronavirus_HKU1_g_4 49907 1977_Human_coronavirus_HKU1_g_5 49908 1978_Human_coronavirus_HKU1_g_1 49909 1978_Human_coronavirus_HKU1_g_2 49910 1978_Human_coronavirus_HKU1_g_3 49911 1978_Human_coronavirus_HKU1_g_4 49912 1978_Human_coronavirus_HKU1_g_5 49913 1979_Human_coronavirus_HKU1_g_1 49914 1979_Human_coronavirus_HKU1_g_2 49915 1979_Human_coronavirus_HKU1_g_3 49916 1979_Human_coronavirus_HKU1_g_4 49917 1979_Human_coronavirus_HKU1_g_5 49918 1980_Human_coronavirus_HKU1_g_1 49919 1980_Human_coronavirus_HKU1_g_2 49920 1980_Human_coronavirus_HKU1_g_3 49921 1980_Human_coronavirus_HKU1_g_4 49922 1980_Human_coronavirus_HKU1_g_5 49923 1981_Human_coronavirus_HKU1_g_1 49924 1981_Human_coronavirus_HKU1_g_2 49925 1981_Human_coronavirus_HKU1_g_3 49926 1981_Human_coronavirus_HKU1_g_4 49927 1981_Human_coronavirus_HKU1_g_5 49928 1982_Human_coronavirus_HKU1_g_1 49929 1982_Human_coronavirus_HKU1_g_2 49930 1982_Human_coronavirus_HKU1_g_3 49931 1982_Human_coronavirus_HKU1_g_4 49932 1982_Human_coronavirus_HKU1_g_5 49933 1983_Human_coronavirus_HKU1_g_1 49934 1983_Human_coronavirus_HKU1_g_2 49935 1983_Human_coronavirus_HKU1_g_3 49936 1983_Human_coronavirus_HKU1_g_4 49937 1983_Human_coronavirus_HKU1_g_5 49938 1984_Human_coronavirus_HKU1_g_1 49939 1984_Human_coronavirus_HKU1_g_2 49940 1984_Human_coronavirus_HKU1_g_3 49941 1984_Human_coronavirus_HKU1_g_4 49942 1984_Human_coronavirus_HKU1_g_5 49943 1985_Human_coronavirus_HKU1_g_1 49944 1985_Human_coronavirus_HKU1_g_2 49945 1985_Human_coronavirus_HKU1_g_3 49946 1985_Human_coronavirus_HKU1_g_4 49947 1985_Human_coronavirus_HKU1_g_5 49948 1986_Human_coronavirus_HKU1_g_1 49949 1986_Human_coronavirus_HKU1_g_2 49950 1986_Human_coronavirus_HKU1_g_3 49951 1986_Human_coronavirus_HKU1_g_4 49952 1986_Human_coronavirus_HKU1_g_5 49953 1987_Human_coronavirus_HKU1_g_1 49954 1987_Human_coronavirus_HKU1_g_2 49955 1987_Human_coronavirus_HKU1_g_3 49956 1987_Human_coronavirus_HKU1_g_4 49957 1987_Human_coronavirus_HKU1_g_5 49958 1988_Human_coronavirus_HKU1_g_1 49959 1988_Human_coronavirus_HKU1_g_2 49960 1988_Human_coronavirus_HKU1_g_3 49961 1988_Human_coronavirus_HKU1_g_4 49962 1988_Human_coronavirus_HKU1_g_5 49963 1989_Human_coronavirus_HKU1_g_1 49964 1989_Human_coronavirus_HKU1_g_2 49965 1989_Human_coronavirus_HKU1_g_3 49966 1989_Human_coronavirus_HKU1_g_4 49967 1989_Human_coronavirus_HKU1_g_5 49968 1990_Human_coronavirus_HKU1_g_1 49969 1990_Human_coronavirus_HKU1_g_2 49970 1990_Human_coronavirus_HKU1_g_3 49971 1990_Human_coronavirus_HKU1_g_4 49972 1990_Human_coronavirus_HKU1_g_5 49973 1991_Human_coronavirus_HKU1_g_1 49974 1991_Human_coronavirus_HKU1_g_2 49975 1991_Human_coronavirus_HKU1_g_3 49976 1991_Human_coronavirus_HKU1_g_4 49977 1991_Human_coronavirus_HKU1_g_5 49978 1992_Human_coronavirus_HKU1_g_1 49979 1992_Human_coronavirus_HKU1_g_2 49980 1992_Human_coronavirus_HKU1_g_3 49981 1992_Human_coronavirus_HKU1_g_4 49982 1992_Human_coronavirus_HKU1_g_5 49983 1993_Human_coronavirus_HKU1_g_1 49984 1993_Human_coronavirus_HKU1_g_2 49985 1993_Human_coronavirus_HKU1_g_3 49986 1993_Human_coronavirus_HKU1_g_4 49987 1993_Human_coronavirus_HKU1_g_5 49988 1994_Human_coronavirus_HKU1_g_1 49989 1994_Human_coronavirus_HKU1_g_2 49990 1994_Human_coronavirus_HKU1_g_3 49991 1994_Human_coronavirus_HKU1_g_4 49992 1994_Human_coronavirus_HKU1_g_5 49993 1995_Human_coronavirus_HKU1_g_1 49994 1995_Human_coronavirus_HKU1_g_2 49995 1995_Human_coronavirus_HKU1_g_3 49996 1995_Human_coronavirus_HKU1_g_4 49997 1995_Human_coronavirus_HKU1_g_5 49998 1996_Human_coronavirus_HKU1_g_1 49999 1996_Human_coronavirus_HKU1_g_2 50000 1996_Human_coronavirus_HKU1_g_3 50001 1996_Human_coronavirus_HKU1_g_4 50002 1996_Human_coronavirus_HKU1_g_5 50003 1997_Human_coronavirus_HKU1_g_1 50004 1997_Human_coronavirus_HKU1_g_2 50005 1997_Human_coronavirus_HKU1_g_3 50006 1997_Human_coronavirus_HKU1_g_4 50007 1997_Human_coronavirus_HKU1_g_5 50008 1998_Human_coronavirus_HKU1_g_1 50009 1998_Human_coronavirus_HKU1_g_2 50010 1998_Human_coronavirus_HKU1_g_3 50011 1998_Human_coronavirus_HKU1_g_4 50012 1998_Human_coronavirus_HKU1_g_5 50013 1999_Human_coronavirus_HKU1_g_1 50014 1999_Human_coronavirus_HKU1_g_2 50015 1999_Human_coronavirus_HKU1_g_3 50016 1999_Human_coronavirus_HKU1_g_4 50017 1999_Human_coronavirus_HKU1_g_5 50018 2000_Human_coronavirus_HKU1_g_1 50019 2000_Human_coronavirus_HKU1_g_2 50020 2000_Human_coronavirus_HKU1_g_3 50021 2000_Human_coronavirus_HKU1_g_4 50022 2000_Human_coronavirus_HKU1_g_5 50023 2001_Human_coronavirus_HKU1_g_1 50024 2001_Human_coronavirus_HKU1_g_2 50025 2001_Human_coronavirus_HKU1_g_3 50026 2001_Human_coronavirus_HKU1_g_4 50027 2001_Human_coronavirus_HKU1_g_5 50028 2002_Human_coronavirus_HKU1_g_1 50029 2002_Human_coronavirus_HKU1_g_2 50030 2002_Human_coronavirus_HKU1_g_3 50031 2002_Human_coronavirus_HKU1_g_4 50032 2002_Human_coronavirus_HKU1_g_5 50033 2003_Human_coronavirus_HKU1_g_1 50034 2003_Human_coronavirus_HKU1_g_2 50035 2003_Human_coronavirus_HKU1_g_3 50036 2003_Human_coronavirus_HKU1_g_4 50037 2003_Human_coronavirus_HKU1_g_5 50038 2004_Human_coronavirus_HKU1_g_1 50039 2004_Human_coronavirus_HKU1_g_2 50040 2004_Human_coronavirus_HKU1_g_3 50041 2004_Human_coronavirus_HKU1_g_4 50042 2004_Human_coronavirus_HKU1_g_5 50043 2005_Human_coronavirus_HKU1_g_1 50044 2005_Human_coronavirus_HKU1_g_2 50045 2005_Human_coronavirus_HKU1_g_3 50046 2005_Human_coronavirus_HKU1_g_4 50047 2005_Human_coronavirus_HKU1_g_5 50048 2006_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50049 segment_3_g_1 2006_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50050 segment_3_g_2 2006_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50051 segment_3_g_3 2006_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50052 segment_3_g_4 2006_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50053 segment_3_g_5 2007_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50054 segment_3_g_1 2007_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50055 segment_3_g_2 2007_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50056 segment_3_g_3 2007_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50057 segment_3_g_4 2007_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50058 segment_3_g_5 2008_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50059 segment_3_g_1 2008_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50060 segment_3_g_2 2008_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50061 segment_3_g_3 2008_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50062 segment_3_g_4 2008_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50063 segment_3_g_5 2009_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50064 segment_3_g_1 2009_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50065 segment_3_g_2 2009_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50066 segment_3_g_3 2009_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50067 segment_3_g_4 2009_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50068 segment_3_g_5 2010_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50069 segment_3_g_1 2010_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50070 segment_3_g_2 2010_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50071 segment_3_g_3 2010_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50072 segment_3_g_4 2010_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50073 segment_3_g_5 2011_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50074 segment_3_g_1 2011_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50075 segment_3_g_2 2011_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50076 segment_3_g_3 2011_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50077 segment_3_g_4 2011_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50078 segment_3_g_5 2012_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50079 segment_3_g_1 2012_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50080 segment_3_g_2 2012_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50081 segment_3_g_3 2012_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50082 segment_3_g_4 2012_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 50083 segment_3_g_5 2013_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50084 segment_5_g_1 2013_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50085 segment_5_g_2 2013_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50086 segment_5_g_3 2013_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50087 segment_5_g_4 2013_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50088 segment_5_g_5 2014_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50089 segment_5_g_1 2014_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50090 segment_5_g_2 2014_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50091 segment_5_g_3 2014_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50092 segment_5_g_4 2014_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50093 segment_5_g_5 2015_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50094 segment_5_g_1 2015_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50095 segment_5_g_2 2015_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50096 segment_5_g_3 2015_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50097 segment_5_g_4 2015_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50098 segment_5_g_5 2016_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50099 segment_5_g_1 2016_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50100 segment_5_g_2 2016_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50101 segment_5_g_3 2016_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50102 segment_5_g_4 2016_Influenza_A_virus_(A/Hong_Kong/1073/99(H9N2))_(—) 50103 segment_5_g_5 2017_Human_papillomavirus_type_132_g_1 50104 2017_Human_papillomavirus_type_132_g_2 50105 2017_Human_papillomavirus_type_132_g_3 50106 2017_Human_papillomavirus_type_132_g_4 50107 2017_Human_papillomavirus_type_132_g_5 50108 2018_Human_papillomavirus_type_132_g_1 50109 2018_Human_papillomavirus_type_132_g_2 50110 2018_Human_papillomavirus_type_132_g_3 50111 2018_Human_papillomavirus_type_132_g_4 50112 2018_Human_papillomavirus_type_132_g_5 50113 2019_Human_papillomavirus_type_132_g_1 50114 2019_Human_papillomavirus_type_132_g_2 50115 2019_Human_papillomavirus_type_132_g_3 50116 2019_Human_papillomavirus_type_132_g_4 50117 2019_Human_papillomavirus_type_132_g_5 50118 2020_Human_papillomavirus_type_132_g_1 50119 2020_Human_papillomavirus_type_132_g_2 50120 2020_Human_papillomavirus_type_132_g_3 50121 2020_Human_papillomavirus_type_132_g_4 50122 2020_Human_papillomavirus_type_132_g_5 50123 2021_Human_papillomavirus_type_132_g_1 50124 2021_Human_papillomavirus_type_132_g_2 50125 2021_Human_papillomavirus_type_132_g_3 50126 2021_Human_papillomavirus_type_132_g_4 50127 2021_Human_papillomavirus_type_132_g_5 50128 2022_Human_papillomavirus_type_132_g_1 50129 2022_Human_papillomavirus_type_132_g_2 50130 2022_Human_papillomavirus_type_132_g_3 50131 2022_Human_papillomavirus_type_132_g_4 50132 2022_Human_papillomavirus_type_132_g_5 50133 2023_Human_papillomavirus_type_132_g_1 50134 2023_Human_papillomavirus_type_132_g_2 50135 2023_Human_papillomavirus_type_132_g_3 50136 2023_Human_papillomavirus_type_132_g_4 50137 2023_Human_papillomavirus_type_132_g_5 50138 2024_Human_papillomavirus_type_132_g_1 50139 2024_Human_papillomavirus_type_132_g_2 50140 2024_Human_papillomavirus_type_132_g_3 50141 2024_Human_papillomavirus_type_132_g_4 50142 2024_Human_papillomavirus_type_132_g_5 50143 2025_Human_papillomavirus_type_132_g_1 50144 2025_Human_papillomavirus_type_132_g_2 50145 2025_Human_papillomavirus_type_132_g_3 50146 2025_Human_papillomavirus_type_132_g_4 50147 2025_Human_papillomavirus_type_132_g_5 50148 2026_Human_papillomavirus_type_132_g_1 50149 2026_Human_papillomavirus_type_132_g_2 50150 2026_Human_papillomavirus_type_132_g_3 50151 2026_Human_papillomavirus_type_132_g_4 50152 2026_Human_papillomavirus_type_132_g_5 50153 2027_Human_papillomavirus_type_132_g_1 50154 2027_Human_papillomavirus_type_132_g_2 50155 2027_Human_papillomavirus_type_132_g_3 50156 2027_Human_papillomavirus_type_132_g_4 50157 2027_Human_papillomavirus_type_132_g_5 50158 2028_Human_papillomavirus_type_132_g_1 50159 2028_Human_papillomavirus_type_132_g_2 50160 2028_Human_papillomavirus_type_132_g_3 50161 2028_Human_papillomavirus_type_132_g_4 50162 2028_Human_papillomavirus_type_132_g_5 50163 2029_Human_papillomavirus_type_132_g_1 50164 2029_Human_papillomavirus_type_132_g_2 50165 2029_Human_papillomavirus_type_132_g_3 50166 2029_Human_papillomavirus_type_132_g_4 50167 2029_Human_papillomavirus_type_132_g_5 50168 2030_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50169 segment_3_polymerase_PA_(PA)_gene_g_1 2030_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50170 segment_3_polymerase_PA_(PA)_gene_g_2 2030_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50171 segment_3_polymerase_PA_(PA)_gene_g_3 2030_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50172 segment_3_polymerase_PA_(PA)_gene_g_4 2030_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50173 segment_3_polymerase_PA_(PA)_gene_g_5 2031_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50174 segment_3_polymerase_PA_(PA)_gene_g_1 2031_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50175 segment_3_polymerase_PA_(PA)_gene_g_2 2031_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50176 segment_3_polymerase_PA_(PA)_gene_g_3 2031_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50177 segment_3_polymerase_PA_(PA)_gene_g_4 2031_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50178 segment_3_polymerase_PA_(PA)_gene_g_5 2032_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50179 segment_3_polymerase_PA_(PA)_gene_g_1 2032_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50180 segment_3_polymerase_PA_(PA)_gene_g_2 2032_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50181 segment_3_polymerase_PA_(PA)_gene_g_3 2032_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50182 segment_3_polymerase_PA_(PA)_gene_g_4 2032_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50183 segment_3_polymerase_PA_(PA)_gene_g_5 2033_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50184 segment_3_polymerase_PA_(PA)_gene_g_1 2033_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50185 segment_3_polymerase_PA_(PA)_gene_g_2 2033_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50186 segment_3_polymerase_PA_(PA)_gene_g_3 2033_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50187 segment_3_polymerase_PA_(PA)_gene_g_4 2033_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50188 segment_3_polymerase_PA_(PA)_gene_g_5 2034_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50189 segment_3_polymerase_PA_(PA)_gene_g_1 2034_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50190 segment_3_polymerase_PA_(PA)_gene_g_2 2034_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50191 segment_3_polymerase_PA_(PA)_gene_g_3 2034_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50192 segment_3_polymerase_PA_(PA)_gene_g_4 2034_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50193 segment_3_polymerase_PA_(PA)_gene_g_5 2035_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50194 segment_3_polymerase_PA_(PA)_gene_g_1 2035_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50195 segment_3_polymerase_PA_(PA)_gene_g_2 2035_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50196 segment_3_polymerase_PA_(PA)_gene_g_3 2035_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50197 segment_3_polymerase_PA_(PA)_gene_g_4 2035_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50198 segment_3_polymerase_PA_(PA)_gene_g_5 2036_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50199 segment_3_polymerase_PA_(PA)_gene_g_1 2036_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50200 segment_3_polymerase_PA_(PA)_gene_g_2 2036_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50201 segment_3_polymerase_PA_(PA)_gene_g_3 2036_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50202 segment_3_polymerase_PA_(PA)_gene_g_4 2036_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50203 segment_3_polymerase_PA_(PA)_gene_g_5 2037_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50204 segment_8_g_1 2037_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50205 segment_8_g_2 2037_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50206 segment_8_g_3 2037_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50207 segment_8_g_4 2037_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50208 segment_8_g_5 2038_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50209 segment_8_g_1 2038_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50210 segment_8_g_2 2038_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50211 segment_8_g_3 2038_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50212 segment_8_g_4 2038_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50213 segment_8_g_5 2039_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50214 segment_8_g_1 2039_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50215 segment_8_g_2 2039_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50216 segment_8_g_3 2039_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50217 segment_8_g_4 2039_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 50218 segment_8_g_5 2040_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_1 50219 2040_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_2 50220 2040_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_3 50221 2040_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_4 50222 2040_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_5 50223 2041_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_1 50224 2041_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_2 50225 2041_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_3 50226 2041_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_4 50227 2041_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_5 50228 2042_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_1 50229 2042_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_2 50230 2042_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_3 50231 2042_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_4 50232 2042_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_5 50233 2043_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_1 50234 2043_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_2 50235 2043_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_3 50236 2043_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_4 50237 2043_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_5 50238 2044_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_1 50239 2044_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_2 50240 2044_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_3 50241 2044_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_4 50242 2044_Influenza_A_virus_pb1_gene_for_polymerase_Pb1_g_5 50243 2045_Human_papillomavirus_type_85_isolate_114B_g_1 50244 2045_Human_papillomavirus_type_85_isolate_114B_g_2 50245 2045_Human_papillomavirus_type_85_isolate_114B_g_3 50246 2045_Human_papillomavirus_type_85_isolate_114B_g_4 50247 2045_Human_papillomavirus_type_85_isolate_114B_g_5 50248 2046_Human_papillomavirus_type_85_isolate_114B_g_1 50249 2046_Human_papillomavirus_type_85_isolate_114B_g_2 50250 2046_Human_papillomavirus_type_85_isolate_114B_g_3 50251 2046_Human_papillomavirus_type_85_isolate_114B_g_4 50252 2046_Human_papillomavirus_type_85_isolate_114B_g_5 50253 2047_Human_papillomavirus_type_85_isolate_114B_g_1 50254 2047_Human_papillomavirus_type_85_isolate_114B_g_2 50255 2047_Human_papillomavirus_type_85_isolate_114B_g_3 50256 2047_Human_papillomavirus_type_85_isolate_114B_g_4 50257 2047_Human_papillomavirus_type_85_isolate_114B_g_5 50258 2048_Human_papillomavirus_type_85_isolate_114B_g_1 50259 2048_Human_papillomavirus_type_85_isolate_114B_g_2 50260 2048_Human_papillomavirus_type_85_isolate_114B_g_3 50261 2048_Human_papillomavirus_type_85_isolate_114B_g_4 50262 2048_Human_papillomavirus_type_85_isolate_114B_g_5 50263 2049_Human_papillomavirus_type_85_isolate_114B_g_1 50264 2049_Human_papillomavirus_type_85_isolate_114B_g_2 50265 2049_Human_papillomavirus_type_85_isolate_114B_g_3 50266 2049_Human_papillomavirus_type_85_isolate_114B_g_4 50267 2049_Human_papillomavirus_type_85_isolate_114B_g_5 50268 2050_Human_papillomavirus_type_85_isolate_114B_g_1 50269 2050_Human_papillomavirus_type_85_isolate_114B_g_2 50270 2050_Human_papillomavirus_type_85_isolate_114B_g_3 50271 2050_Human_papillomavirus_type_85_isolate_114B_g_4 50272 2050_Human_papillomavirus_type_85_isolate_114B_g_5 50273 2051_Human_papillomavirus_type_85_isolate_114B_g_1 50274 2051_Human_papillomavirus_type_85_isolate_114B_g_2 50275 2051_Human_papillomavirus_type_85_isolate_114B_g_3 50276 2051_Human_papillomavirus_type_85_isolate_114B_g_4 50277 2051_Human_papillomavirus_type_85_isolate_114B_g_5 50278 2052_Human_papillomavirus_type_85_isolate_114B_g_1 50279 2052_Human_papillomavirus_type_85_isolate_114B_g_2 50280 2052_Human_papillomavirus_type_85_isolate_114B_g_3 50281 2052_Human_papillomavirus_type_85_isolate_114B_g_4 50282 2052_Human_papillomavirus_type_85_isolate_114B_g_5 50283 2053_Human_papillomavirus_type_85_isolate_114B_g_1 50284 2053_Human_papillomavirus_type_85_isolate_114B_g_2 50285 2053_Human_papillomavirus_type_85_isolate_114B_g_3 50286 2053_Human_papillomavirus_type_85_isolate_114B_g_4 50287 2053_Human_papillomavirus_type_85_isolate_114B_g_5 50288 2054_Human_papillomavirus_type_85_isolate_114B_g_1 50289 2054_Human_papillomavirus_type_85_isolate_114B_g_2 50290 2054_Human_papillomavirus_type_85_isolate_114B_g_3 50291 2054_Human_papillomavirus_type_85_isolate_114B_g_4 50292 2054_Human_papillomavirus_type_85_isolate_114B_g_5 50293 2055_Human_papillomavirus_type_85_isolate_114B_g_1 50294 2055_Human_papillomavirus_type_85_isolate_114B_g_2 50295 2055_Human_papillomavirus_type_85_isolate_114B_g_3 50296 2055_Human_papillomavirus_type_85_isolate_114B_g_4 50297 2055_Human_papillomavirus_type_85_isolate_114B_g_5 50298 2056_Human_papillomavirus_type_85_isolate_114B_g_1 50299 2056_Human_papillomavirus_type_85_isolate_114B_g_2 50300 2056_Human_papillomavirus_type_85_isolate_114B_g_3 50301 2056_Human_papillomavirus_type_85_isolate_114B_g_4 50302 2056_Human_papillomavirus_type_85_isolate_114B_g_5 50303 2057_Human_papillomavirus_type_85_isolate_114B_g_1 50304 2057_Human_papillomavirus_type_85_isolate_114B_g_2 50305 2057_Human_papillomavirus_type_85_isolate_114B_g_3 50306 2057_Human_papillomavirus_type_85_isolate_114B_g_4 50307 2057_Human_papillomavirus_type_85_isolate_114B_g_5 50308 2058_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50309 segment_6_neuraminidase_(NA)_gene_g_1 2058_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50310 segment_6_neuraminidase_(NA)_gene_g_2 2058_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50311 segment_6_neuraminidase_(NA)_gene_g_3 2058_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50312 segment_6_neuraminidase_(NA)_gene_g_4 2058_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50313 segment_6_neuraminidase_(NA)_gene_g_5 2059_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50314 segment_6_neuraminidase_(NA)_gene_g_1 2059_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50315 segment_6_neuraminidase_(NA)_gene_g_2 2059_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50316 segment_6_neuraminidase_(NA)_gene_g_3 2059_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50317 segment_6_neuraminidase_(NA)_gene_g_4 2059_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50318 segment_6_neuraminidase_(NA)_gene_g_5 2060_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50319 segment_6_neuraminidase_(NA)_gene_g_1 2060_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50320 segment_6_neuraminidase_(NA)_gene_g_2 2060_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50321 segment_6_neuraminidase_(NA)_gene_g_3 2060_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50322 segment_6_neuraminidase_(NA)_gene_g_4 2060_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50323 segment_6_neuraminidase_(NA)_gene_g_5 2061_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50324 segment_6_neuraminidase_(NA)_gene_g_1 2061_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50325 segment_6_neuraminidase_(NA)_gene_g_2 2061_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50326 segment_6_neuraminidase_(NA)_gene_g_3 2061_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50327 segment_6_neuraminidase_(NA)_gene_g_4 2061_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_(—) 50328 segment_6_neuraminidase_(NA)_gene_g_5 2062_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50329 segment_1_polymerase_PB2_(PB2)_gene_g_1 2062_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50330 segment_1_polymerase_PB2_(PB2)_gene_g_2 2062_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50331 segment_1_polymerase_PB2_(PB2)_gene_g_3 2062_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50332 segment_1_polymerase_PB2_(PB2)_gene_g_4 2062_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50333 segment_1_polymerase_PB2_(PB2)_gene_g_5 2063_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50334 segment_1_polymerase_PB2_(PB2)_gene_g_1 2063_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50335 segment_1_polymerase_PB2_(PB2)_gene_g_2 2063_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50336 segment_1_polymerase_PB2_(PB2)_gene_g_3 2063_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50337 segment_1_polymerase_PB2_(PB2)_gene_g_4 2063_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50338 segment_1_polymerase_PB2_(PB2)_gene_g_5 2064_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50339 segment_1_polymerase_PB2_(PB2)_gene_g_1 2064_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50340 segment_1_polymerase_PB2_(PB2)_gene_g_2 2064_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50341 segment_1_polymerase_PB2_(PB2)_gene_g_3 2064_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50342 segment_1_polymerase_PB2_(PB2)_gene_g_4 2064_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50343 segment_1_polymerase_PB2_(PB2)_gene_g_5 2065_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50344 segment_1_polymerase_PB2_(PB2)_gene_g_1 2065_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50345 segment_1_polymerase_PB2_(PB2)_gene_g_2 2065_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50346 segment_1_polymerase_PB2_(PB2)_gene_g_3 2065_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50347 segment_1_polymerase_PB2_(PB2)_gene_g_4 2065_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50348 segment_1_polymerase_PB2_(PB2)_gene_g_5 2066_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50349 segment_1_polymerase_PB2_(PB2)_gene_g_1 2066_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50350 segment_1_polymerase_PB2_(PB2)_gene_g_2 2066_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50351 segment_1_polymerase_PB2_(PB2)_gene_g_3 2066_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50352 segment_1_polymerase_PB2_(PB2)_gene_g_4 2066_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50353 segment_1_polymerase_PB2_(PB2)_gene_g_5 2067_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50354 segment_1_polymerase_PB2_(PB2)_gene_g_1 2067_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50355 segment_1_polymerase_PB2_(PB2)_gene_g_2 2067_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50356 segment_1_polymerase_PB2_(PB2)_gene_g_3 2067_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50357 segment_1_polymerase_PB2_(PB2)_gene_g_4 2067_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50358 segment_1_polymerase_PB2_(PB2)_gene_g_5 2068_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50359 segment_1_polymerase_PB2_(PB2)_gene_g_1 2068_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50360 segment_1_polymerase_PB2_(PB2)_gene_g_2 2068_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 50361 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3275_Human_papillomavirus_type_129_g_4 56244 3275_Human_papillomavirus_type_129_g_5 56245 3276_Human_papillomavirus_type_129_g_1 56246 3276_Human_papillomavirus_type_129_g_2 56247 3276_Human_papillomavirus_type_129_g_3 56248 3276_Human_papillomavirus_type_129_g_4 56249 3276_Human_papillomavirus_type_129_g_5 56250 3277_Human_papillomavirus_type_129_g_1 56251 3277_Human_papillomavirus_type_129_g_2 56252 3277_Human_papillomavirus_type_129_g_3 56253 3277_Human_papillomavirus_type_129_g_4 56254 3277_Human_papillomavirus_type_129_g_5 56255 3278_Human_papillomavirus_type_129_g_1 56256 3278_Human_papillomavirus_type_129_g_2 56257 3278_Human_papillomavirus_type_129_g_3 56258 3278_Human_papillomavirus_type_129_g_4 56259 3278_Human_papillomavirus_type_129_g_5 56260 3279_Human_papillomavirus_type_129_g_1 56261 3279_Human_papillomavirus_type_129_g_2 56262 3279_Human_papillomavirus_type_129_g_3 56263 3279_Human_papillomavirus_type_129_g_4 56264 3279_Human_papillomavirus_type_129_g_5 56265 3280_Human_papillomavirus_type_129_g_1 56266 3280_Human_papillomavirus_type_129_g_2 56267 3280_Human_papillomavirus_type_129_g_3 56268 3280_Human_papillomavirus_type_129_g_4 56269 3280_Human_papillomavirus_type_129_g_5 56270 3281_Human_papillomavirus_type_129_g_1 56271 3281_Human_papillomavirus_type_129_g_2 56272 3281_Human_papillomavirus_type_129_g_3 56273 3281_Human_papillomavirus_type_129_g_4 56274 3281_Human_papillomavirus_type_129_g_5 56275 3282_Human_papillomavirus_type_129_g_1 56276 3282_Human_papillomavirus_type_129_g_2 56277 3282_Human_papillomavirus_type_129_g_3do you 56278 have a preferred numbe 3282_Human_papillomavirus_type_129_g_4 56279 3282_Human_papillomavirus_type_129_g_5 56280 3283_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56281 segment_3_g_1 3283_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56282 segment_3_g_2 3283_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56283 segment_3_g_3 3283_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56284 segment_3_g_4 3283_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56285 segment_3_g_5 3284_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56286 segment_3_g_1 3284_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56287 segment_3_g_2 3284_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56288 segment_3_g_3 3284_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56289 segment_3_g_4 3284_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56290 segment_3_g_5 3285_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56291 segment_3_g_1 3285_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56292 segment_3_g_2 3285_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56293 segment_3_g_3 3285_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56294 segment_3_g_4 3285_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56295 segment_3_g_5 3286_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56296 segment_3_g_1 3286_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56297 segment_3_g_2 3286_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56298 segment_3_g_3 3286_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56299 segment_3_g_4 3286_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56300 segment_3_g_5 3287_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56301 segment_3_g_1 3287_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56302 segment_3_g_2 3287_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56303 segment_3_g_3 3287_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56304 segment_3_g_4 3287_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56305 segment_3_g_5 3288_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56306 segment_3_g_1 3288_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56307 segment_3_g_2 3288_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56308 segment_3_g_3 3288_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56309 segment_3_g_4 3288_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56310 segment_3_g_5 3289_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56311 segment_3_g_1 3289_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56312 segment_3_g_2 3289_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56313 segment_3_g_3 3289_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56314 segment_3_g_4 3289_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 56315 segment_3_g_5 3290_Hepatitis_delta_virus_g_1 56316 3290_Hepatitis_delta_virus_g_2 56317 3290_Hepatitis_delta_virus_g_3 56318 3290_Hepatitis_delta_virus_g_4 56319 3290_Hepatitis_delta_virus_g_5 56320 3291_Hepatitis_delta_virus_g_1 56321 3291_Hepatitis_delta_virus_g_2 56322 3291_Hepatitis_delta_virus_g_3 56323 3291_Hepatitis_delta_virus_g_4 56324 3291_Hepatitis_delta_virus_g_5 56325 3292_Hepatitis_delta_virus_g_1 56326 3292_Hepatitis_delta_virus_g_2 56327 3293_Hepatitis_delta_virus_g_1 56328 3293_Hepatitis_delta_virus_g_2 56329 3293_Hepatitis_delta_virus_g_3 56330 3293_Hepatitis_delta_virus_g_4 56331 3293_Hepatitis_delta_virus_g_5 56332 3294_Hepatitis_delta_virus_g_1 56333 3294_Hepatitis_delta_virus_g_2 56334 3294_Hepatitis_delta_virus_g_3 56335 3294_Hepatitis_delta_virus_g_4 56336 3294_Hepatitis_delta_virus_g_5 56337 3295_Human_papillomavirus_type_26_g_1 56338 3295_Human_papillomavirus_type_26_g_2 56339 3295_Human_papillomavirus_type_26_g_3 56340 3295_Human_papillomavirus_type_26_g_4 56341 3295_Human_papillomavirus_type_26_g_5 56342 3296_Human_papillomavirus_type_26_g_1 56343 3296_Human_papillomavirus_type_26_g_2 56344 3296_Human_papillomavirus_type_26_g_3 56345 3296_Human_papillomavirus_type_26_g_4 56346 3296_Human_papillomavirus_type_26_g_5 56347 3297_Human_papillomavirus_type_26_g_1 56348 3297_Human_papillomavirus_type_26_g_2 56349 3297_Human_papillomavirus_type_26_g_3 56350 3297_Human_papillomavirus_type_26_g_4 56351 3297_Human_papillomavirus_type_26_g_5 56352 3298_Human_papillomavirus_type_26_g_1 56353 3298_Human_papillomavirus_type_26_g_2 56354 3298_Human_papillomavirus_type_26_g_3 56355 3298_Human_papillomavirus_type_26_g_4 56356 3298_Human_papillomavirus_type_26_g_5 56357 3299_Human_papillomavirus_type_26_g_1 56358 3299_Human_papillomavirus_type_26_g_2 56359 3299_Human_papillomavirus_type_26_g_3 56360 3299_Human_papillomavirus_type_26_g_4 56361 3299_Human_papillomavirus_type_26_g_5 56362 3300_Human_papillomavirus_type_26_g_1 56363 3300_Human_papillomavirus_type_26_g_2 56364 3300_Human_papillomavirus_type_26_g_3 56365 3300_Human_papillomavirus_type_26_g_4 56366 3300_Human_papillomavirus_type_26_g_5 56367 3301_Human_papillomavirus_type_26_g_1 56368 3301_Human_papillomavirus_type_26_g_2 56369 3301_Human_papillomavirus_type_26_g_3 56370 3301_Human_papillomavirus_type_26_g_4 56371 3301_Human_papillomavirus_type_26_g_5 56372 3302_Human_papillomavirus_type_26_g_1 56373 3302_Human_papillomavirus_type_26_g_2 56374 3302_Human_papillomavirus_type_26_g_3 56375 3302_Human_papillomavirus_type_26_g_4 56376 3302_Human_papillomavirus_type_26_g_5 56377 3303_Human_papillomavirus_type_26_g_1 56378 3303_Human_papillomavirus_type_26_g_2 56379 3303_Human_papillomavirus_type_26_g_3 56380 3303_Human_papillomavirus_type_26_g_4 56381 3304_Human_papillomavirus_type_26_g_1 56382 3304_Human_papillomavirus_type_26_g_2 56383 3304_Human_papillomavirus_type_26_g_3 56384 3304_Human_papillomavirus_type_26_g_4 56385 3304_Human_papillomavirus_type_26_g_5 56386 3305_Human_papillomavirus_type_26_g_1 56387 3305_Human_papillomavirus_type_26_g_2 56388 3305_Human_papillomavirus_type_26_g_3 56389 3305_Human_papillomavirus_type_26_g_4 56390 3305_Human_papillomavirus_type_26_g_5 56391 3306_Human_papillomavirus_type_26_g_1 56392 3306_Human_papillomavirus_type_26_g_2 56393 3306_Human_papillomavirus_type_26_g_3 56394 3306_Human_papillomavirus_type_26_g_4 56395 3306_Human_papillomavirus_type_26_g_5 56396 3307_Human_papillomavirus_type_26_g_1 56397 3307_Human_papillomavirus_type_26_g_2 56398 3307_Human_papillomavirus_type_26_g_3 56399 3307_Human_papillomavirus_type_26_g_4 56400 3307_Human_papillomavirus_type_26_g_5 56401 3308_Human_papillomavirus_type_26_g_1 56402 3308_Human_papillomavirus_type_26_g_2 56403 3308_Human_papillomavirus_type_26_g_3 56404 3308_Human_papillomavirus_type_26_g_4 56405 3308_Human_papillomavirus_type_26_g_5 56406 3309_Human_papillomavirus_type_26_g_1 56407 3309_Human_papillomavirus_type_26_g_2 56408 3309_Human_papillomavirus_type_26_g_3 56409 3309_Human_papillomavirus_type_26_g_4 56410 3309_Human_papillomavirus_type_26_g_5 56411 3310_Human_papillomavirus_type_26_g_1 56412 3310_Human_papillomavirus_type_26_g_2 56413 3310_Human_papillomavirus_type_26_g_3 56414 3310_Human_papillomavirus_type_26_g_4 56415 3310_Human_papillomavirus_type_26_g_5 56416 3311_Human_papillomavirus_type_26_g_1 56417 3311_Human_papillomavirus_type_26_g_2 56418 3311_Human_papillomavirus_type_26_g_3 56419 3311_Human_papillomavirus_type_26_g_4 56420 3311_Human_papillomavirus_type_26_g_5 56421 3312_Hepatitis_GB_virus_B_g_1 56422 3312_Hepatitis_GB_virus_B_g_2 56423 3312_Hepatitis_GB_virus_B_g_3 56424 3312_Hepatitis_GB_virus_B_g_4 56425 3312_Hepatitis_GB_virus_B_g_5 56426 3313_Hepatitis_GB_virus_B_g_1 56427 3313_Hepatitis_GB_virus_B_g_2 56428 3313_Hepatitis_GB_virus_B_g_3 56429 3313_Hepatitis_GB_virus_B_g_4 56430 3313_Hepatitis_GB_virus_B_g_5 56431 3314_Hepatitis_GB_virus_B_g_1 56432 3314_Hepatitis_GB_virus_B_g_2 56433 3314_Hepatitis_GB_virus_B_g_3 56434 3314_Hepatitis_GB_virus_B_g_4 56435 3314_Hepatitis_GB_virus_B_g_5 56436 3315_Hepatitis_GB_virus_B_g_1 56437 3315_Hepatitis_GB_virus_B_g_2 56438 3315_Hepatitis_GB_virus_B_g_3 56439 3315_Hepatitis_GB_virus_B_g_4 56440 3315_Hepatitis_GB_virus_B_g_5 56441 3316_Hepatitis_GB_virus_B_g_1 56442 3316_Hepatitis_GB_virus_B_g_2 56443 3316_Hepatitis_GB_virus_B_g_3 56444 3316_Hepatitis_GB_virus_B_g_4 56445 3316_Hepatitis_GB_virus_B_g_5 56446 3317_Hepatitis_GB_virus_B_g_1 56447 3317_Hepatitis_GB_virus_B_g_2 56448 3317_Hepatitis_GB_virus_B_g_3 56449 3317_Hepatitis_GB_virus_B_g_4 56450 3317_Hepatitis_GB_virus_B_g_5 56451 3318_Hepatitis_GB_virus_B_g_1 56452 3318_Hepatitis_GB_virus_B_g_2 56453 3318_Hepatitis_GB_virus_B_g_3 56454 3318_Hepatitis_GB_virus_B_g_4 56455 3318_Hepatitis_GB_virus_B_g_5 56456 3319_Hepatitis_GB_virus_B_g_1 56457 3319_Hepatitis_GB_virus_B_g_2 56458 3319_Hepatitis_GB_virus_B_g_3 56459 3319_Hepatitis_GB_virus_B_g_4 56460 3319_Hepatitis_GB_virus_B_g_5 56461 3320_Hepatitis_GB_virus_B_g_1 56462 3320_Hepatitis_GB_virus_B_g_2 56463 3320_Hepatitis_GB_virus_B_g_3 56464 3320_Hepatitis_GB_virus_B_g_4 56465 3320_Hepatitis_GB_virus_B_g_5 56466 3321_Hepatitis_GB_virus_B_g_1 56467 3321_Hepatitis_GB_virus_B_g_2 56468 3321_Hepatitis_GB_virus_B_g_3 56469 3321_Hepatitis_GB_virus_B_g_4 56470 3321_Hepatitis_GB_virus_B_g_5 56471 3322_Hepatitis_GB_virus_B_g_1 56472 3322_Hepatitis_GB_virus_B_g_2 56473 3322_Hepatitis_GB_virus_B_g_3 56474 3322_Hepatitis_GB_virus_B_g_4 56475 3322_Hepatitis_GB_virus_B_g_5 56476 3323_Hepatitis_GB_virus_B_g_1 56477 3323_Hepatitis_GB_virus_B_g_2 56478 3323_Hepatitis_GB_virus_B_g_3 56479 3323_Hepatitis_GB_virus_B_g_4 56480 3323_Hepatitis_GB_virus_B_g_5 56481 3324_Hepatitis_GB_virus_B_g_1 56482 3324_Hepatitis_GB_virus_B_g_2 56483 3324_Hepatitis_GB_virus_B_g_3 56484 3324_Hepatitis_GB_virus_B_g_4 56485 3324_Hepatitis_GB_virus_B_g_5 56486 3325_Hepatitis_GB_virus_B_g_1 56487 3325_Hepatitis_GB_virus_B_g_2 56488 3325_Hepatitis_GB_virus_B_g_3 56489 3325_Hepatitis_GB_virus_B_g_4 56490 3325_Hepatitis_GB_virus_B_g_5 56491 3326_Hepatitis_GB_virus_B_g_1 56492 3326_Hepatitis_GB_virus_B_g_2 56493 3326_Hepatitis_GB_virus_B_g_3 56494 3326_Hepatitis_GB_virus_B_g_4 56495 3326_Hepatitis_GB_virus_B_g_5 56496 3327_Hepatitis_GB_virus_B_g_1 56497 3327_Hepatitis_GB_virus_B_g_2 56498 3327_Hepatitis_GB_virus_B_g_3 56499 3327_Hepatitis_GB_virus_B_g_4 56500 3327_Hepatitis_GB_virus_B_g_5 56501 3328_Hepatitis_GB_virus_B_g_1 56502 3328_Hepatitis_GB_virus_B_g_2 56503 3328_Hepatitis_GB_virus_B_g_3 56504 3328_Hepatitis_GB_virus_B_g_4 56505 3328_Hepatitis_GB_virus_B_g_5 56506 3329_Hepatitis_GB_virus_B_g_1 56507 3329_Hepatitis_GB_virus_B_g_2 56508 3329_Hepatitis_GB_virus_B_g_3 56509 3329_Hepatitis_GB_virus_B_g_4 56510 3329_Hepatitis_GB_virus_B_g_5 56511 3330_Hepatitis_GB_virus_B_g_1 56512 3330_Hepatitis_GB_virus_B_g_2 56513 3330_Hepatitis_GB_virus_B_g_3 56514 3330_Hepatitis_GB_virus_B_g_4 56515 3330_Hepatitis_GB_virus_B_g_5 56516 3331_Hepatitis_GB_virus_B_g_1 56517 3331_Hepatitis_GB_virus_B_g_2 56518 3331_Hepatitis_GB_virus_B_g_3 56519 3331_Hepatitis_GB_virus_B_g_4 56520 3331_Hepatitis_GB_virus_B_g_5 56521 3332_Hepatitis_GB_virus_B_g_1 56522 3332_Hepatitis_GB_virus_B_g_2 56523 3332_Hepatitis_GB_virus_B_g_3 56524 3332_Hepatitis_GB_virus_B_g_4 56525 3332_Hepatitis_GB_virus_B_g_5 56526 3333_Hepatitis_GB_virus_B_g_1 56527 3333_Hepatitis_GB_virus_B_g_2 56528 3333_Hepatitis_GB_virus_B_g_3 56529 3333_Hepatitis_GB_virus_B_g_4 56530 3333_Hepatitis_GB_virus_B_g_5 56531 3334_Hepatitis_GB_virus_B_g_1 56532 3334_Hepatitis_GB_virus_B_g_2 56533 3334_Hepatitis_GB_virus_B_g_3 56534 3334_Hepatitis_GB_virus_B_g_4 56535 3334_Hepatitis_GB_virus_B_g_5 56536 3335_Hepatitis_GB_virus_B_g_1 56537 3335_Hepatitis_GB_virus_B_g_2 56538 3335_Hepatitis_GB_virus_B_g_3 56539 3335_Hepatitis_GB_virus_B_g_4 56540 3335_Hepatitis_GB_virus_B_g_5 56541 3336_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56542 segment_6_g_1 3336_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56543 segment_6_g_2 3336_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56544 segment_6_g_3 3336_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56545 segment_6_g_4 3336_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56546 segment_6_g_5 3337_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56547 segment_6_g_1 3337_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56548 segment_6_g_2 3337_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56549 segment_6_g_3 3337_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56550 segment_6_g_4 3337_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56551 segment_6_g_5 3338_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56552 segment_6_g_1 3338_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56553 segment_6_g_2 3338_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56554 segment_6_g_3 3338_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56555 segment_6_g_4 3338_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56556 segment_6_g_5 3339_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56557 segment_6_g_1 3339_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56558 segment_6_g_2 3339_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56559 segment_6_g_3 3339_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56560 segment_6_g_4 3339_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56561 segment_6_g_5 3340_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56562 segment_6_g_1 3340_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56563 segment_6_g_2 3340_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56564 segment_6_g_3 3340_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56565 segment_6_g_4 3340_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 56566 segment_6_g_5 3341_Human_papillomavirus_isolate_SE379_g_1 56567 3341_Human_papillomavirus_isolate_SE379_g_2 56568 3341_Human_papillomavirus_isolate_SE379_g_3 56569 3341_Human_papillomavirus_isolate_SE379_g_4 56570 3341_Human_papillomavirus_isolate_SE379_g_5 56571 3342_Human_papillomavirus_isolate_SE379_g_1 56572 3342_Human_papillomavirus_isolate_SE379_g_2 56573 3342_Human_papillomavirus_isolate_SE379_g_3 56574 3342_Human_papillomavirus_isolate_SE379_g_4 56575 3342_Human_papillomavirus_isolate_SE379_g_5 56576 3343_Human_papillomavirus_isolate_SE379_g_1 56577 3343_Human_papillomavirus_isolate_SE379_g_2 56578 3343_Human_papillomavirus_isolate_SE379_g_3 56579 3343_Human_papillomavirus_isolate_SE379_g_4 56580 3343_Human_papillomavirus_isolate_SE379_g_5 56581 3344_Human_papillomavirus_isolate_SE379_g_1 56582 3344_Human_papillomavirus_isolate_SE379_g_2 56583 3344_Human_papillomavirus_isolate_SE379_g_3 56584 3344_Human_papillomavirus_isolate_SE379_g_4 56585 3344_Human_papillomavirus_isolate_SE379_g_5 56586 3345_Human_papillomavirus_isolate_SE379_g_1 56587 3345_Human_papillomavirus_isolate_SE379_g_2 56588 3345_Human_papillomavirus_isolate_SE379_g_3 56589 3345_Human_papillomavirus_isolate_SE379_g_4 56590 3345_Human_papillomavirus_isolate_SE379_g_5 56591 3346_Human_papillomavirus_isolate_SE379_g_1 56592 3346_Human_papillomavirus_isolate_SE379_g_2 56593 3346_Human_papillomavirus_isolate_SE379_g_3 56594 3346_Human_papillomavirus_isolate_SE379_g_4 56595 3346_Human_papillomavirus_isolate_SE379_g_5 56596 3347_Human_papillomavirus_isolate_SE379_g_1 56597 3347_Human_papillomavirus_isolate_SE379_g_2 56598 3347_Human_papillomavirus_isolate_SE379_g_3 56599 3347_Human_papillomavirus_isolate_SE379_g_4 56600 3347_Human_papillomavirus_isolate_SE379_g_5 56601 3348_Human_papillomavirus_isolate_SE379_g_1 56602 3348_Human_papillomavirus_isolate_SE379_g_2 56603 3348_Human_papillomavirus_isolate_SE379_g_3 56604 3348_Human_papillomavirus_isolate_SE379_g_4 56605 3348_Human_papillomavirus_isolate_SE379_g_5 56606 3349_Human_papillomavirus_isolate_SE379_g_1 56607 3349_Human_papillomavirus_isolate_SE379_g_2 56608 3349_Human_papillomavirus_isolate_SE379_g_3 56609 3349_Human_papillomavirus_isolate_SE379_g_4 56610 3349_Human_papillomavirus_isolate_SE379_g_5 56611 3350_Human_papillomavirus_isolate_SE379_g_1 56612 3350_Human_papillomavirus_isolate_SE379_g_2 56613 3350_Human_papillomavirus_isolate_SE379_g_3 56614 3350_Human_papillomavirus_isolate_SE379_g_4 56615 3350_Human_papillomavirus_isolate_SE379_g_5 56616 3351_Human_papillomavirus_isolate_SE379_g_1 56617 3351_Human_papillomavirus_isolate_SE379_g_2 56618 3351_Human_papillomavirus_isolate_SE379_g_3 56619 3351_Human_papillomavirus_isolate_SE379_g_4 56620 3351_Human_papillomavirus_isolate_SE379_g_5 56621 3352_Human_papillomavirus_isolate_SE379_g_1 56622 3352_Human_papillomavirus_isolate_SE379_g_2 56623 3352_Human_papillomavirus_isolate_SE379_g_3 56624 3352_Human_papillomavirus_isolate_SE379_g_4 56625 3352_Human_papillomavirus_isolate_SE379_g_5 56626 3353_Influenza_A_virus_ha_gene_for_hemagglutinin_g_1 56627 3353_Influenza_A_virus_ha_gene_for_hemagglutinin_g_2 56628 3353_Influenza_A_virus_ha_gene_for_hemagglutinin_g_3 56629 3353_Influenza_A_virus_ha_gene_for_hemagglutinin_g_4 56630 3353_Influenza_A_virus_ha_gene_for_hemagglutinin_g_5 56631 3354_Influenza_A_virus_ha_gene_for_hemagglutinin_g_1 56632 3354_Influenza_A_virus_ha_gene_for_hemagglutinin_g_2 56633 3354_Influenza_A_virus_ha_gene_for_hemagglutinin_g_3 56634 3354_Influenza_A_virus_ha_gene_for_hemagglutinin_g_4 56635 3354_Influenza_A_virus_ha_gene_for_hemagglutinin_g_5 56636 3355_Influenza_A_virus_ha_gene_for_hemagglutinin_g_1 56637 3355_Influenza_A_virus_ha_gene_for_hemagglutinin_g_2 56638 3355_Influenza_A_virus_ha_gene_for_hemagglutinin_g_3 56639 3355_Influenza_A_virus_ha_gene_for_hemagglutinin_g_4 56640 3355_Influenza_A_virus_ha_gene_for_hemagglutinin_g_5 56641 3356_Influenza_A_virus_ha_gene_for_hemagglutinin_g_1 56642 3356_Influenza_A_virus_ha_gene_for_hemagglutinin_g_2 56643 3356_Influenza_A_virus_ha_gene_for_hemagglutinin_g_3 56644 3356_Influenza_A_virus_ha_gene_for_hemagglutinin_g_4 56645 3356_Influenza_A_virus_ha_gene_for_hemagglutinin_g_5 56646 3357_Influenza_A_virus_ha_gene_for_hemagglutinin_g_1 56647 3357_Influenza_A_virus_ha_gene_for_hemagglutinin_g_2 56648 3357_Influenza_A_virus_ha_gene_for_hemagglutinin_g_3 56649 3357_Influenza_A_virus_ha_gene_for_hemagglutinin_g_4 56650 3357_Influenza_A_virus_ha_gene_for_hemagglutinin_g_5 56651 3358_Hepatitis_C_virus_genotype_5_g_1 56652 3358_Hepatitis_C_virus_genotype_5_g_2 56653 3358_Hepatitis_C_virus_genotype_5_g_3 56654 3358_Hepatitis_C_virus_genotype_5_g_4 56655 3358_Hepatitis_C_virus_genotype_5_g_5 56656 3359_Hepatitis_C_virus_genotype_5_g_1 56657 3359_Hepatitis_C_virus_genotype_5_g_2 56658 3359_Hepatitis_C_virus_genotype_5_g_3 56659 3359_Hepatitis_C_virus_genotype_5_g_4 56660 3359_Hepatitis_C_virus_genotype_5_g_5 56661 3360_Hepatitis_C_virus_genotype_5_g_1 56662 3360_Hepatitis_C_virus_genotype_5_g_2 56663 3360_Hepatitis_C_virus_genotype_5_g_3 56664 3360_Hepatitis_C_virus_genotype_5_g_4 56665 3360_Hepatitis_C_virus_genotype_5_g_5 56666 3361_Hepatitis_C_virus_genotype_5_g_1 56667 3361_Hepatitis_C_virus_genotype_5_g_2 56668 3361_Hepatitis_C_virus_genotype_5_g_3 56669 3361_Hepatitis_C_virus_genotype_5_g_4 56670 3361_Hepatitis_C_virus_genotype_5_g_5 56671 3362_Hepatitis_C_virus_genotype_5_g_1 56672 3362_Hepatitis_C_virus_genotype_5_g_2 56673 3362_Hepatitis_C_virus_genotype_5_g_3 56674 3362_Hepatitis_C_virus_genotype_5_g_4 56675 3362_Hepatitis_C_virus_genotype_5_g_5 56676 3363_Hepatitis_C_virus_genotype_5_g_1 56677 3363_Hepatitis_C_virus_genotype_5_g_2 56678 3363_Hepatitis_C_virus_genotype_5_g_3 56679 3363_Hepatitis_C_virus_genotype_5_g_4 56680 3363_Hepatitis_C_virus_genotype_5_g_5 56681 3364_Hepatitis_C_virus_genotype_5_g_1 56682 3364_Hepatitis_C_virus_genotype_5_g_2 56683 3364_Hepatitis_C_virus_genotype_5_g_3 56684 3364_Hepatitis_C_virus_genotype_5_g_4 56685 3364_Hepatitis_C_virus_genotype_5_g_5 56686 3365_Hepatitis_C_virus_genotype_5_g_1 56687 3365_Hepatitis_C_virus_genotype_5_g_2 56688 3365_Hepatitis_C_virus_genotype_5_g_3 56689 3365_Hepatitis_C_virus_genotype_5_g_4 56690 3365_Hepatitis_C_virus_genotype_5_g_5 56691 3366_Hepatitis_C_virus_genotype_5_g_1 56692 3366_Hepatitis_C_virus_genotype_5_g_2 56693 3366_Hepatitis_C_virus_genotype_5_g_3 56694 3366_Hepatitis_C_virus_genotype_5_g_4 56695 3366_Hepatitis_C_virus_genotype_5_g_5 56696 3367_Hepatitis_C_virus_genotype_5_g_1 56697 3367_Hepatitis_C_virus_genotype_5_g_2 56698 3367_Hepatitis_C_virus_genotype_5_g_3 56699 3367_Hepatitis_C_virus_genotype_5_g_4 56700 3367_Hepatitis_C_virus_genotype_5_g_5 56701 3368_Hepatitis_C_virus_genotype_5_g_1 56702 3368_Hepatitis_C_virus_genotype_5_g_2 56703 3368_Hepatitis_C_virus_genotype_5_g_3 56704 3368_Hepatitis_C_virus_genotype_5_g_4 56705 3368_Hepatitis_C_virus_genotype_5_g_5 56706 3369_Hepatitis_C_virus_genotype_5_g_1 56707 3369_Hepatitis_C_virus_genotype_5_g_2 56708 3369_Hepatitis_C_virus_genotype_5_g_3 56709 3369_Hepatitis_C_virus_genotype_5_g_4 56710 3369_Hepatitis_C_virus_genotype_5_g_5 56711 3370_Hepatitis_C_virus_genotype_5_g_1 56712 3370_Hepatitis_C_virus_genotype_5_g_2 56713 3370_Hepatitis_C_virus_genotype_5_g_3 56714 3370_Hepatitis_C_virus_genotype_5_g_4 56715 3371_Hepatitis_C_virus_genotype_5_g_1 56716 3371_Hepatitis_C_virus_genotype_5_g_2 56717 3371_Hepatitis_C_virus_genotype_5_g_3 56718 3371_Hepatitis_C_virus_genotype_5_g_4 56719 3371_Hepatitis_C_virus_genotype_5_g_5 56720 3372_Hepatitis_C_virus_genotype_5_g_1 56721 3372_Hepatitis_C_virus_genotype_5_g_2 56722 3373_Hepatitis_C_virus_genotype_5_g_1 56723 3373_Hepatitis_C_virus_genotype_5_g_2 56724 3373_Hepatitis_C_virus_genotype_5_g_3 56725 3373_Hepatitis_C_virus_genotype_5_g_4 56726 3373_Hepatitis_C_virus_genotype_5_g_5 56727 3374_Hepatitis_C_virus_genotype_5_g_1 56728 3374_Hepatitis_C_virus_genotype_5_g_2 56729 3374_Hepatitis_C_virus_genotype_5_g_3 56730 3374_Hepatitis_C_virus_genotype_5_g_4 56731 3374_Hepatitis_C_virus_genotype_5_g_5 56732 3375_Hepatitis_C_virus_genotype_5_g_1 56733 3375_Hepatitis_C_virus_genotype_5_g_2 56734 3375_Hepatitis_C_virus_genotype_5_g_3 56735 3375_Hepatitis_C_virus_genotype_5_g_4 56736 3376_Hepatitis_C_virus_genotype_5_g_1 56737 3376_Hepatitis_C_virus_genotype_5_g_2 56738 3376_Hepatitis_C_virus_genotype_5_g_3 56739 3376_Hepatitis_C_virus_genotype_5_g_4 56740 3376_Hepatitis_C_virus_genotype_5_g_5 56741 3377_Hepatitis_C_virus_genotype_5_g_1 56742 3377_Hepatitis_C_virus_genotype_5_g_2 56743 3377_Hepatitis_C_virus_genotype_5_g_3 56744 3377_Hepatitis_C_virus_genotype_5_g_4 56745 3377_Hepatitis_C_virus_genotype_5_g_5 56746 3378_Hepatitis_C_virus_genotype_5_g_1 56747 3378_Hepatitis_C_virus_genotype_5_g_2 56748 3378_Hepatitis_C_virus_genotype_5_g_3 56749 3378_Hepatitis_C_virus_genotype_5_g_4 56750 3378_Hepatitis_C_virus_genotype_5_g_5 56751 3379_Hepatitis_C_virus_genotype_5_g_1 56752 3379_Hepatitis_C_virus_genotype_5_g_2 56753 3379_Hepatitis_C_virus_genotype_5_g_3 56754 3379_Hepatitis_C_virus_genotype_5_g_4 56755 3379_Hepatitis_C_virus_genotype_5_g_5 56756 3380_Hepatitis_C_virus_genotype_5_g_1 56757 3380_Hepatitis_C_virus_genotype_5_g_2 56758 3380_Hepatitis_C_virus_genotype_5_g_3 56759 3380_Hepatitis_C_virus_genotype_5_g_4 56760 3380_Hepatitis_C_virus_genotype_5_g_5 56761 3381_Hepatitis_C_virus_genotype_5_g_1 56762 3381_Hepatitis_C_virus_genotype_5_g_2 56763 3381_Hepatitis_C_virus_genotype_5_g_3 56764 3381_Hepatitis_C_virus_genotype_5_g_4 56765 3381_Hepatitis_C_virus_genotype_5_g_5 56766 3382_Hepatitis_C_virus_genotype_5_g_1 56767 3382_Hepatitis_C_virus_genotype_5_g_2 56768 3382_Hepatitis_C_virus_genotype_5_g_3 56769 3383_Hepatitis_C_virus_genotype_5_g_1 56770 3383_Hepatitis_C_virus_genotype_5_g_2 56771 3383_Hepatitis_C_virus_genotype_5_g_3 56772 3383_Hepatitis_C_virus_genotype_5_g_4 56773 3383_Hepatitis_C_virus_genotype_5_g_5 56774 3384_Hepatitis_C_virus_genotype_5_g_1 56775 3384_Hepatitis_C_virus_genotype_5_g_2 56776 3384_Hepatitis_C_virus_genotype_5_g_3 56777 3384_Hepatitis_C_virus_genotype_5_g_4 56778 3384_Hepatitis_C_virus_genotype_5_g_5 56779 3385_SARS_coronavirus_g_1 56780 3385_SARS_coronavirus_g_2 56781 3385_SARS_coronavirus_g_3 56782 3385_SARS_coronavirus_g_4 56783 3385_SARS_coronavirus_g_5 56784 3386_SARS_coronavirus_g_1 56785 3386_SARS_coronavirus_g_2 56786 3386_SARS_coronavirus_g_3 56787 3386_SARS_coronavirus_g_4 56788 3386_SARS_coronavirus_g_5 56789 3387_SARS_coronavirus_g_1 56790 3387_SARS_coronavirus_g_2 56791 3387_SARS_coronavirus_g_3 56792 3387_SARS_coronavirus_g_4 56793 3387_SARS_coronavirus_g_5 56794 3388_SARS_coronavirus_g_1 56795 3388_SARS_coronavirus_g_2 56796 3388_SARS_coronavirus_g_3 56797 3388_SARS_coronavirus_g_4 56798 3388_SARS_coronavirus_g_5 56799 3389_SARS_coronavirus_g_1 56800 3389_SARS_coronavirus_g_2 56801 3389_SARS_coronavirus_g_3 56802 3389_SARS_coronavirus_g_4 56803 3389_SARS_coronavirus_g_5 56804 3390_SARS_coronavirus_g_1 56805 3390_SARS_coronavirus_g_2 56806 3390_SARS_coronavirus_g_3 56807 3390_SARS_coronavirus_g_4 56808 3390_SARS_coronavirus_g_5 56809 3391_SARS_coronavirus_g_1 56810 3391_SARS_coronavirus_g_2 56811 3391_SARS_coronavirus_g_3 56812 3391_SARS_coronavirus_g_4 56813 3391_SARS_coronavirus_g_5 56814 3392_SARS_coronavirus_g_1 56815 3392_SARS_coronavirus_g_2 56816 3392_SARS_coronavirus_g_3 56817 3392_SARS_coronavirus_g_4 56818 3392_SARS_coronavirus_g_5 56819 3393_SARS_coronavirus_g_1 56820 3393_SARS_coronavirus_g_2 56821 3393_SARS_coronavirus_g_3 56822 3393_SARS_coronavirus_g_4 56823 3393_SARS_coronavirus_g_5 56824 3394_SARS_coronavirus_g_1 56825 3394_SARS_coronavirus_g_2 56826 3394_SARS_coronavirus_g_3 56827 3394_SARS_coronavirus_g_4 56828 3394_SARS_coronavirus_g_5 56829 3395_SARS_coronavirus_g_1 56830 3395_SARS_coronavirus_g_2 56831 3395_SARS_coronavirus_g_3 56832 3395_SARS_coronavirus_g_4 56833 3395_SARS_coronavirus_g_5 56834 3396_SARS_coronavirus_g_1 56835 3396_SARS_coronavirus_g_2 56836 3396_SARS_coronavirus_g_3 56837 3396_SARS_coronavirus_g_4 56838 3396_SARS_coronavirus_g_5 56839 3397_SARS_coronavirus_g_1 56840 3397_SARS_coronavirus_g_2 56841 3397_SARS_coronavirus_g_3 56842 3397_SARS_coronavirus_g_4 56843 3397_SARS_coronavirus_g_5 56844 3398_SARS_coronavirus_g_1 56845 3398_SARS_coronavirus_g_2 56846 3398_SARS_coronavirus_g_3 56847 3398_SARS_coronavirus_g_4 56848 3398_SARS_coronavirus_g_5 56849 3399_SARS_coronavirus_g_1 56850 3399_SARS_coronavirus_g_2 56851 3399_SARS_coronavirus_g_3 56852 3399_SARS_coronavirus_g_4 56853 3399_SARS_coronavirus_g_5 56854 3400_SARS_coronavirus_g_1 56855 3400_SARS_coronavirus_g_2 56856 3400_SARS_coronavirus_g_3 56857 3400_SARS_coronavirus_g_4 56858 3400_SARS_coronavirus_g_5 56859 3401_SARS_coronavirus_g_1 56860 3401_SARS_coronavirus_g_2 56861 3401_SARS_coronavirus_g_3 56862 3401_SARS_coronavirus_g_4 56863 3401_SARS_coronavirus_g_5 56864 3402_SARS_coronavirus_g_1 56865 3402_SARS_coronavirus_g_2 56866 3402_SARS_coronavirus_g_3 56867 3402_SARS_coronavirus_g_4 56868 3402_SARS_coronavirus_g_5 56869 3403_SARS_coronavirus_g_1 56870 3403_SARS_coronavirus_g_2 56871 3403_SARS_coronavirus_g_3 56872 3403_SARS_coronavirus_g_4 56873 3403_SARS_coronavirus_g_5 56874 3404_SARS_coronavirus_g_1 56875 3404_SARS_coronavirus_g_2 56876 3404_SARS_coronavirus_g_3 56877 3404_SARS_coronavirus_g_4 56878 3404_SARS_coronavirus_g_5 56879 3405_SARS_coronavirus_g_1 56880 3405_SARS_coronavirus_g_2 56881 3405_SARS_coronavirus_g_3 56882 3405_SARS_coronavirus_g_4 56883 3405_SARS_coronavirus_g_5 56884 3406_SARS_coronavirus_g_1 56885 3406_SARS_coronavirus_g_2 56886 3406_SARS_coronavirus_g_3 56887 3406_SARS_coronavirus_g_4 56888 3406_SARS_coronavirus_g_5 56889 3407_SARS_coronavirus_g_1 56890 3407_SARS_coronavirus_g_2 56891 3407_SARS_coronavirus_g_3 56892 3407_SARS_coronavirus_g_4 56893 3407_SARS_coronavirus_g_5 56894 3408_SARS_coronavirus_g_1 56895 3408_SARS_coronavirus_g_2 56896 3408_SARS_coronavirus_g_3 56897 3408_SARS_coronavirus_g_4 56898 3408_SARS_coronavirus_g_5 56899 3409_SARS_coronavirus_g_1 56900 3409_SARS_coronavirus_g_2 56901 3409_SARS_coronavirus_g_3 56902 3409_SARS_coronavirus_g_4 56903 3409_SARS_coronavirus_g_5 56904 3410_SARS_coronavirus_g_1 56905 3410_SARS_coronavirus_g_2 56906 3410_SARS_coronavirus_g_3 56907 3410_SARS_coronavirus_g_4 56908 3410_SARS_coronavirus_g_5 56909 3411_SARS_coronavirus_g_1 56910 3411_SARS_coronavirus_g_2 56911 3411_SARS_coronavirus_g_3 56912 3411_SARS_coronavirus_g_4 56913 3411_SARS_coronavirus_g_5 56914 3412_SARS_coronavirus_g_1 56915 3412_SARS_coronavirus_g_2 56916 3412_SARS_coronavirus_g_3 56917 3412_SARS_coronavirus_g_4 56918 3412_SARS_coronavirus_g_5 56919 3413_SARS_coronavirus_g_1 56920 3413_SARS_coronavirus_g_2 56921 3413_SARS_coronavirus_g_3 56922 3413_SARS_coronavirus_g_4 56923 3413_SARS_coronavirus_g_5 56924 3414_SARS_coronavirus_g_1 56925 3414_SARS_coronavirus_g_2 56926 3414_SARS_coronavirus_g_3 56927 3414_SARS_coronavirus_g_4 56928 3414_SARS_coronavirus_g_5 56929 3415_SARS_coronavirus_g_1 56930 3415_SARS_coronavirus_g_2 56931 3415_SARS_coronavirus_g_3 56932 3415_SARS_coronavirus_g_4 56933 3415_SARS_coronavirus_g_5 56934 3416_SARS_coronavirus_g_1 56935 3416_SARS_coronavirus_g_2 56936 3416_SARS_coronavirus_g_3 56937 3416_SARS_coronavirus_g_4 56938 3416_SARS_coronavirus_g_5 56939 3417_SARS_coronavirus_g_1 56940 3417_SARS_coronavirus_g_2 56941 3417_SARS_coronavirus_g_3 56942 3417_SARS_coronavirus_g_4 56943 3417_SARS_coronavirus_g_5 56944 3418_SARS_coronavirus_g_1 56945 3418_SARS_coronavirus_g_2 56946 3418_SARS_coronavirus_g_3 56947 3418_SARS_coronavirus_g_4 56948 3418_SARS_coronavirus_g_5 56949 3419_SARS_coronavirus_g_1 56950 3419_SARS_coronavirus_g_2 56951 3419_SARS_coronavirus_g_3 56952 3419_SARS_coronavirus_g_4 56953 3419_SARS_coronavirus_g_5 56954 3420_SARS_coronavirus_g_1 56955 3420_SARS_coronavirus_g_2 56956 3420_SARS_coronavirus_g_3 56957 3420_SARS_coronavirus_g_4 56958 3420_SARS_coronavirus_g_5 56959 3421_SARS_coronavirus_g_1 56960 3421_SARS_coronavirus_g_2 56961 3421_SARS_coronavirus_g_3 56962 3421_SARS_coronavirus_g_4 56963 3421_SARS_coronavirus_g_5 56964 3422_SARS_coronavirus_g_1 56965 3422_SARS_coronavirus_g_2 56966 3422_SARS_coronavirus_g_3 56967 3422_SARS_coronavirus_g_4 56968 3422_SARS_coronavirus_g_5 56969 3423_SARS_coronavirus_g_1 56970 3423_SARS_coronavirus_g_2 56971 3423_SARS_coronavirus_g_3 56972 3423_SARS_coronavirus_g_4 56973 3423_SARS_coronavirus_g_5 56974 3424_SARS_coronavirus_g_1 56975 3424_SARS_coronavirus_g_2 56976 3424_SARS_coronavirus_g_3 56977 3424_SARS_coronavirus_g_4 56978 3424_SARS_coronavirus_g_5 56979 3425_SARS_coronavirus_g_1 56980 3425_SARS_coronavirus_g_2 56981 3425_SARS_coronavirus_g_3 56982 3425_SARS_coronavirus_g_4 56983 3425_SARS_coronavirus_g_5 56984 3426_SARS_coronavirus_g_1 56985 3426_SARS_coronavirus_g_2 56986 3426_SARS_coronavirus_g_3 56987 3426_SARS_coronavirus_g_4 56988 3426_SARS_coronavirus_g_5 56989 3427_SARS_coronavirus_g_1 56990 3427_SARS_coronavirus_g_2 56991 3427_SARS_coronavirus_g_3 56992 3427_SARS_coronavirus_g_4 56993 3427_SARS_coronavirus_g_5 56994 3428_SARS_coronavirus_g_1 56995 3428_SARS_coronavirus_g_2 56996 3428_SARS_coronavirus_g_3 56997 3428_SARS_coronavirus_g_4 56998 3428_SARS_coronavirus_g_5 56999 3429_SARS_coronavirus_g_1 57000 3429_SARS_coronavirus_g_2 57001 3429_SARS_coronavirus_g_3 57002 3429_SARS_coronavirus_g_4 57003 3429_SARS_coronavirus_g_5 57004 3430_SARS_coronavirus_g_1 57005 3430_SARS_coronavirus_g_2 57006 3430_SARS_coronavirus_g_3 57007 3430_SARS_coronavirus_g_4 57008 3430_SARS_coronavirus_g_5 57009 3431_SARS_coronavirus_g_1 57010 3431_SARS_coronavirus_g_2 57011 3431_SARS_coronavirus_g_3 57012 3431_SARS_coronavirus_g_4 57013 3431_SARS_coronavirus_g_5 57014 3432_SARS_coronavirus_g_1 57015 3432_SARS_coronavirus_g_2 57016 3432_SARS_coronavirus_g_3 57017 3432_SARS_coronavirus_g_4 57018 3432_SARS_coronavirus_g_5 57019 3433_SARS_coronavirus_g_1 57020 3433_SARS_coronavirus_g_2 57021 3433_SARS_coronavirus_g_3 57022 3433_SARS_coronavirus_g_4 57023 3433_SARS_coronavirus_g_5 57024 3434_SARS_coronavirus_g_1 57025 3434_SARS_coronavirus_g_2 57026 3434_SARS_coronavirus_g_3 57027 3434_SARS_coronavirus_g_4 57028 3434_SARS_coronavirus_g_5 57029 3435_SARS_coronavirus_g_1 57030 3435_SARS_coronavirus_g_2 57031 3435_SARS_coronavirus_g_3 57032 3435_SARS_coronavirus_g_4 57033 3435_SARS_coronavirus_g_5 57034 3436_SARS_coronavirus_g_1 57035 3436_SARS_coronavirus_g_2 57036 3436_SARS_coronavirus_g_3 57037 3436_SARS_coronavirus_g_4 57038 3436_SARS_coronavirus_g_5 57039 3437_SARS_coronavirus_g_1 57040 3437_SARS_coronavirus_g_2 57041 3437_SARS_coronavirus_g_3 57042 3437_SARS_coronavirus_g_4 57043 3437_SARS_coronavirus_g_5 57044 3438_SARS_coronavirus_g_1 57045 3438_SARS_coronavirus_g_2 57046 3438_SARS_coronavirus_g_3 57047 3438_SARS_coronavirus_g_4 57048 3438_SARS_coronavirus_g_5 57049 3439_SARS_coronavirus_g_1 57050 3439_SARS_coronavirus_g_2 57051 3439_SARS_coronavirus_g_3 57052 3439_SARS_coronavirus_g_4 57053 3439_SARS_coronavirus_g_5 57054 3440_SARS_coronavirus_g_1 57055 3440_SARS_coronavirus_g_2 57056 3440_SARS_coronavirus_g_3 57057 3440_SARS_coronavirus_g_4 57058 3440_SARS_coronavirus_g_5 57059 3441_SARS_coronavirus_g_1 57060 3441_SARS_coronavirus_g_2 57061 3441_SARS_coronavirus_g_3 57062 3441_SARS_coronavirus_g_4 57063 3441_SARS_coronavirus_g_5 57064 3442_SARS_coronavirus_g_1 57065 3442_SARS_coronavirus_g_2 57066 3442_SARS_coronavirus_g_3 57067 3442_SARS_coronavirus_g_4 57068 3442_SARS_coronavirus_g_5 57069 3443_SARS_coronavirus_g_1 57070 3443_SARS_coronavirus_g_2 57071 3443_SARS_coronavirus_g_3 57072 3443_SARS_coronavirus_g_4 57073 3443_SARS_coronavirus_g_5 57074 3444_SARS_coronavirus_g_1 57075 3444_SARS_coronavirus_g_2 57076 3444_SARS_coronavirus_g_3 57077 3444_SARS_coronavirus_g_4 57078 3444_SARS_coronavirus_g_5 57079 3445_SARS_coronavirus_g_1 57080 3445_SARS_coronavirus_g_2 57081 3445_SARS_coronavirus_g_3 57082 3445_SARS_coronavirus_g_4 57083 3445_SARS_coronavirus_g_5 57084 3446_SARS_coronavirus_g_1 57085 3446_SARS_coronavirus_g_2 57086 3446_SARS_coronavirus_g_3 57087 3446_SARS_coronavirus_g_4 57088 3446_SARS_coronavirus_g_5 57089 3447_SARS_coronavirus_g_1 57090 3447_SARS_coronavirus_g_2 57091 3447_SARS_coronavirus_g_3 57092 3447_SARS_coronavirus_g_4 57093 3447_SARS_coronavirus_g_5 57094 3448_SARS_coronavirus_g_1 57095 3448_SARS_coronavirus_g_2 57096 3448_SARS_coronavirus_g_3 57097 3448_SARS_coronavirus_g_4 57098 3448_SARS_coronavirus_g_5 57099 3449_SARS_coronavirus_g_1 57100 3449_SARS_coronavirus_g_2 57101 3449_SARS_coronavirus_g_3 57102 3449_SARS_coronavirus_g_4 57103 3449_SARS_coronavirus_g_5 57104 3450_SARS_coronavirus_g_1 57105 3450_SARS_coronavirus_g_2 57106 3450_SARS_coronavirus_g_3 57107 3450_SARS_coronavirus_g_4 57108 3450_SARS_coronavirus_g_5 57109 3451_SARS_coronavirus_g_1 57110 3451_SARS_coronavirus_g_2 57111 3451_SARS_coronavirus_g_3 57112 3451_SARS_coronavirus_g_4 57113 3451_SARS_coronavirus_g_5 57114 3452_SARS_coronavirus_g_1 57115 3452_SARS_coronavirus_g_2 57116 3452_SARS_coronavirus_g_3 57117 3452_SARS_coronavirus_g_4 57118 3452_SARS_coronavirus_g_5 57119 3453_SARS_coronavirus_g_1 57120 3453_SARS_coronavirus_g_2 57121 3453_SARS_coronavirus_g_3 57122 3453_SARS_coronavirus_g_4 57123 3453_SARS_coronavirus_g_5 57124 3454_SARS_coronavirus_g_1 57125 3454_SARS_coronavirus_g_2 57126 3454_SARS_coronavirus_g_3 57127 3454_SARS_coronavirus_g_4 57128 3454_SARS_coronavirus_g_5 57129 3455_SARS_coronavirus_g_1 57130 3455_SARS_coronavirus_g_2 57131 3455_SARS_coronavirus_g_3 57132 3455_SARS_coronavirus_g_4 57133 3455_SARS_coronavirus_g_5 57134 3456_SARS_coronavirus_g_1 57135 3456_SARS_coronavirus_g_2 57136 3456_SARS_coronavirus_g_3 57137 3456_SARS_coronavirus_g_4 57138 3456_SARS_coronavirus_g_5 57139 3457_SARS_coronavirus_g_1 57140 3457_SARS_coronavirus_g_2 57141 3457_SARS_coronavirus_g_3 57142 3457_SARS_coronavirus_g_4 57143 3457_SARS_coronavirus_g_5 57144 3458_SARS_coronavirus_g_1 57145 3458_SARS_coronavirus_g_2 57146 3458_SARS_coronavirus_g_3 57147 3458_SARS_coronavirus_g_4 57148 3458_SARS_coronavirus_g_5 57149 3459_SARS_coronavirus_g_1 57150 3459_SARS_coronavirus_g_2 57151 3459_SARS_coronavirus_g_3 57152 3459_SARS_coronavirus_g_4 57153 3459_SARS_coronavirus_g_5 57154 3460_SARS_coronavirus_g_1 57155 3460_SARS_coronavirus_g_2 57156 3460_SARS_coronavirus_g_3 57157 3460_SARS_coronavirus_g_4 57158 3460_SARS_coronavirus_g_5 57159 3461_SARS_coronavirus_g_1 57160 3461_SARS_coronavirus_g_2 57161 3461_SARS_coronavirus_g_3 57162 3461_SARS_coronavirus_g_4 57163 3461_SARS_coronavirus_g_5 57164 3462_SARS_coronavirus_g_1 57165 3462_SARS_coronavirus_g_2 57166 3462_SARS_coronavirus_g_3 57167 3462_SARS_coronavirus_g_4 57168 3462_SARS_coronavirus_g_5 57169 3463_SARS_coronavirus_g_1 57170 3463_SARS_coronavirus_g_2 57171 3463_SARS_coronavirus_g_3 57172 3463_SARS_coronavirus_g_4 57173 3463_SARS_coronavirus_g_5 57174 3464_SARS_coronavirus_g_1 57175 3464_SARS_coronavirus_g_2 57176 3464_SARS_coronavirus_g_3 57177 3464_SARS_coronavirus_g_4 57178 3464_SARS_coronavirus_g_5 57179 3465_SARS_coronavirus_g_1 57180 3465_SARS_coronavirus_g_2 57181 3465_SARS_coronavirus_g_3 57182 3465_SARS_coronavirus_g_4 57183 3465_SARS_coronavirus_g_5 57184 3466_SARS_coronavirus_g_1 57185 3466_SARS_coronavirus_g_2 57186 3466_SARS_coronavirus_g_3 57187 3466_SARS_coronavirus_g_4 57188 3466_SARS_coronavirus_g_5 57189 3467_SARS_coronavirus_g_1 57190 3467_SARS_coronavirus_g_2 57191 3467_SARS_coronavirus_g_3 57192 3467_SARS_coronavirus_g_4 57193 3467_SARS_coronavirus_g_5 57194 3468_SARS_coronavirus_g_1 57195 3468_SARS_coronavirus_g_2 57196 3468_SARS_coronavirus_g_3 57197 3468_SARS_coronavirus_g_4 57198 3468_SARS_coronavirus_g_5 57199 3469_SARS_coronavirus_g_1 57200 3469_SARS_coronavirus_g_2 57201 3469_SARS_coronavirus_g_3 57202 3469_SARS_coronavirus_g_4 57203 3469_SARS_coronavirus_g_5 57204 3470_SARS_coronavirus_g_1 57205 3470_SARS_coronavirus_g_2 57206 3470_SARS_coronavirus_g_3 57207 3470_SARS_coronavirus_g_4 57208 3470_SARS_coronavirus_g_5 57209 3471_Human_rhinovirus_89_g_1 57210 3471_Human_rhinovirus_89_g_2 57211 3471_Human_rhinovirus_89_g_3 57212 3471_Human_rhinovirus_89_g_4 57213 3471_Human_rhinovirus_89_g_5 57214 3472_Human_rhinovirus_89_g_1 57215 3472_Human_rhinovirus_89_g_2 57216 3472_Human_rhinovirus_89_g_3 57217 3472_Human_rhinovirus_89_g_4 57218 3472_Human_rhinovirus_89_g_5 57219 3473_Human_rhinovirus_89_g_1 57220 3473_Human_rhinovirus_89_g_2 57221 3473_Human_rhinovirus_89_g_3 57222 3473_Human_rhinovirus_89_g_4 57223 3473_Human_rhinovirus_89_g_5 57224 3474_Human_rhinovirus_89_g_1 57225 3474_Human_rhinovirus_89_g_2 57226 3474_Human_rhinovirus_89_g_3 57227 3474_Human_rhinovirus_89_g_4 57228 3474_Human_rhinovirus_89_g_5 57229 3475_Human_rhinovirus_89_g_1 57230 3475_Human_rhinovirus_89_g_2 57231 3475_Human_rhinovirus_89_g_3 57232 3475_Human_rhinovirus_89_g_4 57233 3475_Human_rhinovirus_89_g_5 57234 3476_Human_rhinovirus_89_g_1 57235 3476_Human_rhinovirus_89_g_2 57236 3476_Human_rhinovirus_89_g_3 57237 3476_Human_rhinovirus_89_g_4 57238 3476_Human_rhinovirus_89_g_5 57239 3477_Human_rhinovirus_89_g_1 57240 3477_Human_rhinovirus_89_g_2 57241 3477_Human_rhinovirus_89_g_3 57242 3477_Human_rhinovirus_89_g_4 57243 3477_Human_rhinovirus_89_g_5 57244 3478_Human_rhinovirus_89_g_1 57245 3478_Human_rhinovirus_89_g_2 57246 3478_Human_rhinovirus_89_g_3 57247 3478_Human_rhinovirus_89_g_4 57248 3478_Human_rhinovirus_89_g_5 57249 3479_Human_rhinovirus_89_g_1 57250 3479_Human_rhinovirus_89_g_2 57251 3479_Human_rhinovirus_89_g_3 57252 3479_Human_rhinovirus_89_g_4 57253 3479_Human_rhinovirus_89_g_5 57254 3480_Human_rhinovirus_89_g_1 57255 3480_Human_rhinovirus_89_g_2 57256 3480_Human_rhinovirus_89_g_3 57257 3480_Human_rhinovirus_89_g_4 57258 3480_Human_rhinovirus_89_g_5 57259 3481_Human_rhinovirus_89_g_1 57260 3481_Human_rhinovirus_89_g_2 57261 3481_Human_rhinovirus_89_g_3 57262 3481_Human_rhinovirus_89_g_4 57263 3481_Human_rhinovirus_89_g_5 57264 3482_Human_rhinovirus_89_g_1 57265 3482_Human_rhinovirus_89_g_2 57266 3482_Human_rhinovirus_89_g_3 57267 3482_Human_rhinovirus_89_g_4 57268 3482_Human_rhinovirus_89_g_5 57269 3483_Human_rhinovirus_89_g_1 57270 3483_Human_rhinovirus_89_g_2 57271 3483_Human_rhinovirus_89_g_3 57272 3483_Human_rhinovirus_89_g_4 57273 3483_Human_rhinovirus_89_g_5 57274 3484_Human_rhinovirus_89_g_1 57275 3484_Human_rhinovirus_89_g_2 57276 3484_Human_rhinovirus_89_g_3 57277 3484_Human_rhinovirus_89_g_4 57278 3484_Human_rhinovirus_89_g_5 57279 3485_Human_rhinovirus_89_g_1 57280 3485_Human_rhinovirus_89_g_2 57281 3485_Human_rhinovirus_89_g_3 57282 3485_Human_rhinovirus_89_g_4 57283 3485_Human_rhinovirus_89_g_5 57284 3486_Human_rhinovirus_89_g_1 57285 3486_Human_rhinovirus_89_g_2 57286 3486_Human_rhinovirus_89_g_3 57287 3486_Human_rhinovirus_89_g_4 57288 3486_Human_rhinovirus_89_g_5 57289 3487_Human_rhinovirus_89_g_1 57290 3487_Human_rhinovirus_89_g_2 57291 3487_Human_rhinovirus_89_g_3 57292 3487_Human_rhinovirus_89_g_4 57293 3487_Human_rhinovirus_89_g_5 57294 3488_Human_rhinovirus_89_g_1 57295 3488_Human_rhinovirus_89_g_2 57296 3488_Human_rhinovirus_89_g_3 57297 3488_Human_rhinovirus_89_g_4 57298 3488_Human_rhinovirus_89_g_5 57299 3489_Human_rhinovirus_89_g_1 57300 3489_Human_rhinovirus_89_g_2 57301 3489_Human_rhinovirus_89_g_3 57302 3489_Human_rhinovirus_89_g_4 57303 3489_Human_rhinovirus_89_g_5 57304 3490_Human_rhinovirus_89_g_1 57305 3490_Human_rhinovirus_89_g_2 57306 3490_Human_rhinovirus_89_g_3 57307 3490_Human_rhinovirus_89_g_4 57308 3490_Human_rhinovirus_89_g_5 57309 3491_Human_rhinovirus_89_g_1 57310 3491_Human_rhinovirus_89_g_2 57311 3491_Human_rhinovirus_89_g_3 57312 3491_Human_rhinovirus_89_g_4 57313 3491_Human_rhinovirus_89_g_5 57314 3492_Human_rhinovirus_89_g_1 57315 3492_Human_rhinovirus_89_g_2 57316 3492_Human_rhinovirus_89_g_3 57317 3492_Human_rhinovirus_89_g_4 57318 3492_Human_rhinovirus_89_g_5 57319 3493_Human_papillomavirus_type_131_g_1 57320 3493_Human_papillomavirus_type_131_g_2 57321 3493_Human_papillomavirus_type_131_g_3 57322 3493_Human_papillomavirus_type_131_g_4 57323 3493_Human_papillomavirus_type_131_g_5 57324 3494_Human_papillomavirus_type_131_g_1 57325 3494_Human_papillomavirus_type_131_g_2 57326 3494_Human_papillomavirus_type_131_g_3 57327 3494_Human_papillomavirus_type_131_g_4 57328 3494_Human_papillomavirus_type_131_g_5 57329 3495_Human_papillomavirus_type_131_g_1 57330 3495_Human_papillomavirus_type_131_g_2 57331 3495_Human_papillomavirus_type_131_g_3 57332 3495_Human_papillomavirus_type_131_g_4 57333 3495_Human_papillomavirus_type_131_g_5 57334 3496_Human_papillomavirus_type_131_g_1 57335 3496_Human_papillomavirus_type_131_g_2 57336 3496_Human_papillomavirus_type_131_g_3 57337 3496_Human_papillomavirus_type_131_g_4 57338 3496_Human_papillomavirus_type_131_g_5 57339 3497_Human_papillomavirus_type_131_g_1 57340 3497_Human_papillomavirus_type_131_g_2 57341 3497_Human_papillomavirus_type_131_g_3 57342 3497_Human_papillomavirus_type_131_g_4 57343 3497_Human_papillomavirus_type_131_g_5 57344 3498_Human_papillomavirus_type_131_g_1 57345 3498_Human_papillomavirus_type_131_g_2 57346 3498_Human_papillomavirus_type_131_g_3 57347 3498_Human_papillomavirus_type_131_g_4 57348 3498_Human_papillomavirus_type_131_g_5 57349 3499_Human_papillomavirus_type_131_g_1 57350 3499_Human_papillomavirus_type_131_g_2 57351 3499_Human_papillomavirus_type_131_g_3 57352 3499_Human_papillomavirus_type_131_g_4 57353 3499_Human_papillomavirus_type_131_g_5 57354 3500_Human_papillomavirus_type_131_g_1 57355 3500_Human_papillomavirus_type_131_g_2 57356 3500_Human_papillomavirus_type_131_g_3 57357 3500_Human_papillomavirus_type_131_g_4 57358 3500_Human_papillomavirus_type_131_g_5 57359 3501_Human_papillomavirus_type_131_g_1 57360 3501_Human_papillomavirus_type_131_g_2 57361 3501_Human_papillomavirus_type_131_g_3 57362 3501_Human_papillomavirus_type_131_g_4 57363 3501_Human_papillomavirus_type_131_g_5 57364 3502_Human_papillomavirus_type_131_g_1 57365 3502_Human_papillomavirus_type_131_g_2 57366 3502_Human_papillomavirus_type_131_g_3 57367 3502_Human_papillomavirus_type_131_g_4 57368 3502_Human_papillomavirus_type_131_g_5 57369 3503_Human_papillomavirus_type_131_g_1 57370 3503_Human_papillomavirus_type_131_g_2 57371 3503_Human_papillomavirus_type_131_g_3 57372 3503_Human_papillomavirus_type_131_g_4 57373 3503_Human_papillomavirus_type_131_g_5 57374 3504_Human_papillomavirus_type_131_g_1 57375 3504_Human_papillomavirus_type_131_g_2 57376 3504_Human_papillomavirus_type_131_g_3 57377 3504_Human_papillomavirus_type_131_g_4 57378 3504_Human_papillomavirus_type_131_g_5 57379 3505_Human_papillomavirus_type_131_g_1 57380 3505_Human_papillomavirus_type_131_g_2 57381 3505_Human_papillomavirus_type_131_g_3 57382 3505_Human_papillomavirus_type_131_g_4 57383 3505_Human_papillomavirus_type_131_g_5 57384 3506_Human_papillomavirus_type_135_g_1 57385 3506_Human_papillomavirus_type_135_g_2 57386 3506_Human_papillomavirus_type_135_g_3 57387 3506_Human_papillomavirus_type_135_g_4 57388 3506_Human_papillomavirus_type_135_g_5 57389 3507_Human_papillomavirus_type_135_g_1 57390 3507_Human_papillomavirus_type_135_g_2 57391 3507_Human_papillomavirus_type_135_g_3 57392 3507_Human_papillomavirus_type_135_g_4 57393 3507_Human_papillomavirus_type_135_g_5 57394 3508_Human_papillomavirus_type_135_g_1 57395 3508_Human_papillomavirus_type_135_g_2 57396 3508_Human_papillomavirus_type_135_g_3 57397 3508_Human_papillomavirus_type_135_g_4 57398 3508_Human_papillomavirus_type_135_g_5 57399 3509_Human_papillomavirus_type_135_g_1 57400 3509_Human_papillomavirus_type_135_g_2 57401 3509_Human_papillomavirus_type_135_g_3 57402 3509_Human_papillomavirus_type_135_g_4 57403 3509_Human_papillomavirus_type_135_g_5 57404 3510_Human_papillomavirus_type_135_g_1 57405 3510_Human_papillomavirus_type_135_g_2 57406 3510_Human_papillomavirus_type_135_g_3 57407 3510_Human_papillomavirus_type_135_g_4 57408 3510_Human_papillomavirus_type_135_g_5 57409 3511_Human_papillomavirus_type_135_g_1 57410 3511_Human_papillomavirus_type_135_g_2 57411 3511_Human_papillomavirus_type_135_g_3 57412 3511_Human_papillomavirus_type_135_g_4 57413 3511_Human_papillomavirus_type_135_g_5 57414 3512_Human_papillomavirus_type_135_g_1 57415 3512_Human_papillomavirus_type_135_g_2 57416 3512_Human_papillomavirus_type_135_g_3 57417 3512_Human_papillomavirus_type_135_g_4 57418 3512_Human_papillomavirus_type_135_g_5 57419 3513_Human_papillomavirus_type_135_g_1 57420 3513_Human_papillomavirus_type_135_g_2 57421 3513_Human_papillomavirus_type_135_g_3 57422 3513_Human_papillomavirus_type_135_g_4 57423 3513_Human_papillomavirus_type_135_g_5 57424 3514_Human_papillomavirus_type_135_g_1 57425 3514_Human_papillomavirus_type_135_g_2 57426 3514_Human_papillomavirus_type_135_g_3 57427 3514_Human_papillomavirus_type_135_g_4 57428 3514_Human_papillomavirus_type_135_g_5 57429 3515_Influenza_B_virus_(B/Lee/1940)_segment_7_g_1 57430 3515_Influenza_B_virus_(B/Lee/1940)_segment_7_g_2 57431 3515_Influenza_B_virus_(B/Lee/1940)_segment_7_g_3 57432 3515_Influenza_B_virus_(B/Lee/1940)_segment_7_g_4 57433 3515_Influenza_B_virus_(B/Lee/1940)_segment_7_g_5 57434 3516_Influenza_B_virus_(B/Lee/1940)_segment_7_g_1 57435 3516_Influenza_B_virus_(B/Lee/1940)_segment_7_g_2 57436 3516_Influenza_B_virus_(B/Lee/1940)_segment_7_g_3 57437 3516_Influenza_B_virus_(B/Lee/1940)_segment_7_g_4 57438 3516_Influenza_B_virus_(B/Lee/1940)_segment_7_g_5 57439 3517_Influenza_B_virus_(B/Lee/1940)_segment_7_g_1 57440 3517_Influenza_B_virus_(B/Lee/1940)_segment_7_g_2 57441 3517_Influenza_B_virus_(B/Lee/1940)_segment_7_g_3 57442 3517_Influenza_B_virus_(B/Lee/1940)_segment_7_g_4 57443 3517_Influenza_B_virus_(B/Lee/1940)_segment_7_g_5 57444 3518_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57445 nucleocapsid_protein_(NP)_gene_g_1 3518_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57446 nucleocapsid_protein_(NP)_gene_g_2 3518_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57447 nucleocapsid_protein_(NP)_gene_g_3 3518_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57448 nucleocapsid_protein_(NP)_gene_g_4 3518_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57449 nucleocapsid_protein_(NP)_gene_g_5 3519_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57450 nucleocapsid_protein_(NP)_gene_g_1 3519_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57451 nucleocapsid_protein_(NP)_gene_g_2 3519_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57452 nucleocapsid_protein_(NP)_gene_g_3 3519_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57453 nucleocapsid_protein_(NP)_gene_g_4 3519_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57454 nucleocapsid_protein_(NP)_gene_g_5 3520_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57455 nucleocapsid_protein_(NP)_gene_g_1 3520_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57456 nucleocapsid_protein_(NP)_gene_g_2 3520_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57457 nucleocapsid_protein_(NP)_gene_g_3 3520_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57458 nucleocapsid_protein_(NP)_gene_g_4 3520_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57459 nucleocapsid_protein_(NP)_gene_g_5 3521_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57460 nucleocapsid_protein_(NP)_gene_g_1 3521_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57461 nucleocapsid_protein_(NP)_gene_g_2 3521_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57462 nucleocapsid_protein_(NP)_gene_g_3 3521_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57463 nucleocapsid_protein_(NP)_gene_g_4 3521_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 57464 nucleocapsid_protein_(NP)_gene_g_5 3522_Streptococcus_pyogenes_strain_NCTC8198_(—) 57465 chromosome_1_g_1 3522_Streptococcus_pyogenes_strain_NCTC8198_(—) 57466 chromosome_1_g_2 3522_Streptococcus_pyogenes_strain_NCTC8198_(—) 57467 chromosome_1_g_3 3522_Streptococcus_pyogenes_strain_NCTC8198_(—) 57468 chromosome_1_g_4 3522_Streptococcus_pyogenes_strain_NCTC8198_(—) 57469 chromosome_1_g_5 3523_Streptococcus_pyogenes_strain_NCTC8198_(—) 57470 chromosome_1_g_1 3523_Streptococcus_pyogenes_strain_NCTC8198_(—) 57471 chromosome_1_g_2 3523_Streptococcus_pyogenes_strain_NCTC8198_(—) 57472 chromosome_1_g_3 3523_Streptococcus_pyogenes_strain_NCTC8198_(—) 57473 chromosome_1_g_4 3523_Streptococcus_pyogenes_strain_NCTC8198_(—) 57474 chromosome_1_g_5 3524_Streptococcus_pyogenes_strain_NCTC8198_(—) 57475 chromosome_1_g_1 3524_Streptococcus_pyogenes_strain_NCTC8198_(—) 57476 chromosome_1_g_2 3524_Streptococcus_pyogenes_strain_NCTC8198_(—) 57477 chromosome_1_g_3 3524_Streptococcus_pyogenes_strain_NCTC8198_(—) 57478 chromosome_1_g_4 3524_Streptococcus_pyogenes_strain_NCTC8198_(—) 57479 chromosome_1_g_5 3525_Streptococcus_pyogenes_strain_NCTC8198_(—) 57480 chromosome_1_g_1 3525_Streptococcus_pyogenes_strain_NCTC8198_(—) 57481 chromosome_1_g_2 3525_Streptococcus_pyogenes_strain_NCTC8198_(—) 57482 chromosome_1_g_3 3525_Streptococcus_pyogenes_strain_NCTC8198_(—) 57483 chromosome_1_g_4 3525_Streptococcus_pyogenes_strain_NCTC8198_(—) 57484 chromosome_1_g_5 3526_Streptococcus_pyogenes_strain_NCTC8198_(—) 57485 chromosome_1_g_1 3526_Streptococcus_pyogenes_strain_NCTC8198_(—) 57486 chromosome_1_g_2 3526_Streptococcus_pyogenes_strain_NCTC8198_(—) 57487 chromosome_1_g_3 3526_Streptococcus_pyogenes_strain_NCTC8198_(—) 57488 chromosome_1_g_4 3526_Streptococcus_pyogenes_strain_NCTC8198_(—) 57489 chromosome_1_g_5 3527_Streptococcus_pyogenes_strain_NCTC8198_(—) 57490 chromosome_1_g_1 3527_Streptococcus_pyogenes_strain_NCTC8198_(—) 57491 chromosome_1_g_2 3527_Streptococcus_pyogenes_strain_NCTC8198_(—) 57492 chromosome_1_g_3 3527_Streptococcus_pyogenes_strain_NCTC8198_(—) 57493 chromosome_1_g_4 3527_Streptococcus_pyogenes_strain_NCTC8198_(—) 57494 chromosome_1_g_5 3528_Streptococcus_pyogenes_strain_NCTC8198_(—) 57495 chromosome_1_g_1 3528_Streptococcus_pyogenes_strain_NCTC8198_(—) 57496 chromosome_1_g_2 3528_Streptococcus_pyogenes_strain_NCTC8198_(—) 57497 chromosome_1_g_3 3528_Streptococcus_pyogenes_strain_NCTC8198_(—) 57498 chromosome_1_g_4 3528_Streptococcus_pyogenes_strain_NCTC8198_(—) 57499 chromosome_1_g_5 3529_Streptococcus_pyogenes_strain_NCTC8198_(—) 57500 chromosome_1_g_1 3529_Streptococcus_pyogenes_strain_NCTC8198_(—) 57501 chromosome_1_g_2 3529_Streptococcus_pyogenes_strain_NCTC8198_(—) 57502 chromosome_1_g_3 3529_Streptococcus_pyogenes_strain_NCTC8198_(—) 57503 chromosome_1_g_4 3529_Streptococcus_pyogenes_strain_NCTC8198_(—) 57504 chromosome_1_g_5 3530_Streptococcus_pyogenes_strain_NCTC8198_(—) 57505 chromosome_1_g_1 3530_Streptococcus_pyogenes_strain_NCTC8198_(—) 57506 chromosome_1_g_2 3530_Streptococcus_pyogenes_strain_NCTC8198_(—) 57507 chromosome_1_g_3 3530_Streptococcus_pyogenes_strain_NCTC8198_(—) 57508 chromosome_1_g_4 3530_Streptococcus_pyogenes_strain_NCTC8198_(—) 57509 chromosome_1_g_5 3531_Streptococcus_pyogenes_strain_NCTC8198_(—) 57510 chromosome_1_g_1 3531_Streptococcus_pyogenes_strain_NCTC8198_(—) 57511 chromosome_1_g_2 3531_Streptococcus_pyogenes_strain_NCTC8198_(—) 57512 chromosome_1_g_3 3531_Streptococcus_pyogenes_strain_NCTC8198_(—) 57513 chromosome_1_g_4 3531_Streptococcus_pyogenes_strain_NCTC8198_(—) 57514 chromosome_1_g_5 3532_Streptococcus_pyogenes_strain_NCTC8198_(—) 57515 chromosome_1_g_1 3532_Streptococcus_pyogenes_strain_NCTC8198_(—) 57516 chromosome_1_g_2 3532_Streptococcus_pyogenes_strain_NCTC8198_(—) 57517 chromosome_1_g_3 3532_Streptococcus_pyogenes_strain_NCTC8198_(—) 57518 chromosome_1_g_4 3532_Streptococcus_pyogenes_strain_NCTC8198_(—) 57519 chromosome_1_g_5 3533_Streptococcus_pyogenes_strain_NCTC8198_(—) 57520 chromosome_1_g_1 3533_Streptococcus_pyogenes_strain_NCTC8198_(—) 57521 chromosome_1_g_2 3533_Streptococcus_pyogenes_strain_NCTC8198_(—) 57522 chromosome_1_g_3 3533_Streptococcus_pyogenes_strain_NCTC8198_(—) 57523 chromosome_1_g_4 3533_Streptococcus_pyogenes_strain_NCTC8198_(—) 57524 chromosome_1_g_5 3534_Streptococcus_pyogenes_strain_NCTC8198_(—) 57525 chromosome_1_g_1 3534_Streptococcus_pyogenes_strain_NCTC8198_(—) 57526 chromosome_1_g_2 3534_Streptococcus_pyogenes_strain_NCTC8198_(—) 57527 chromosome_1_g_3 3534_Streptococcus_pyogenes_strain_NCTC8198_(—) 57528 chromosome_1_g_4 3534_Streptococcus_pyogenes_strain_NCTC8198_(—) 57529 chromosome_1_g_5 3535_Streptococcus_pyogenes_strain_NCTC8198_(—) 57530 chromosome_1_g_1 3535_Streptococcus_pyogenes_strain_NCTC8198_(—) 57531 chromosome_1_g_2 3535_Streptococcus_pyogenes_strain_NCTC8198_(—) 57532 chromosome_1_g_3 3535_Streptococcus_pyogenes_strain_NCTC8198_(—) 57533 chromosome_1_g_4 3535_Streptococcus_pyogenes_strain_NCTC8198_(—) 57534 chromosome_1_g_5 3536_Streptococcus_pyogenes_strain_NCTC8198_(—) 57535 chromosome_1_g_1 3536_Streptococcus_pyogenes_strain_NCTC8198_(—) 57536 chromosome_1_g_2 3536_Streptococcus_pyogenes_strain_NCTC8198_(—) 57537 chromosome_1_g_3 3536_Streptococcus_pyogenes_strain_NCTC8198_(—) 57538 chromosome_1_g_4 3536_Streptococcus_pyogenes_strain_NCTC8198_(—) 57539 chromosome_1_g_5 3537_Streptococcus_pyogenes_strain_NCTC8198_(—) 57540 chromosome_1_g_1 3537_Streptococcus_pyogenes_strain_NCTC8198_(—) 57541 chromosome_1_g_2 3537_Streptococcus_pyogenes_strain_NCTC8198_(—) 57542 chromosome_1_g_3 3537_Streptococcus_pyogenes_strain_NCTC8198_(—) 57543 chromosome_1_g_4 3537_Streptococcus_pyogenes_strain_NCTC8198_(—) 57544 chromosome_1_g_5 3538_Streptococcus_pyogenes_strain_NCTC8198_(—) 57545 chromosome_1_g_1 3538_Streptococcus_pyogenes_strain_NCTC8198_(—) 57546 chromosome_1_g_2 3538_Streptococcus_pyogenes_strain_NCTC8198_(—) 57547 chromosome_1_g_3 3538_Streptococcus_pyogenes_strain_NCTC8198_(—) 57548 chromosome_1_g_4 3538_Streptococcus_pyogenes_strain_NCTC8198_(—) 57549 chromosome_1_g_5 3539_Streptococcus_pyogenes_strain_NCTC8198_(—) 57550 chromosome_1_g_1 3539_Streptococcus_pyogenes_strain_NCTC8198_(—) 57551 chromosome_1_g_2 3539_Streptococcus_pyogenes_strain_NCTC8198_(—) 57552 chromosome_1_g_3 3539_Streptococcus_pyogenes_strain_NCTC8198_(—) 57553 chromosome_1_g_4 3539_Streptococcus_pyogenes_strain_NCTC8198_(—) 57554 chromosome_1_g_5 3540_Streptococcus_pyogenes_strain_NCTC8198_(—) 57555 chromosome_1_g_1 3540_Streptococcus_pyogenes_strain_NCTC8198_(—) 57556 chromosome_1_g_2 3540_Streptococcus_pyogenes_strain_NCTC8198_(—) 57557 chromosome_1_g_3 3540_Streptococcus_pyogenes_strain_NCTC8198_(—) 57558 chromosome_1_g_4 3540_Streptococcus_pyogenes_strain_NCTC8198_(—) 57559 chromosome_1_g_5 3541_Streptococcus_pyogenes_strain_NCTC8198_(—) 57560 chromosome_1_g_1 3541_Streptococcus_pyogenes_strain_NCTC8198_(—) 57561 chromosome_1_g_2 3541_Streptococcus_pyogenes_strain_NCTC8198_(—) 57562 chromosome_1_g_3 3541_Streptococcus_pyogenes_strain_NCTC8198_(—) 57563 chromosome_1_g_4 3541_Streptococcus_pyogenes_strain_NCTC8198_(—) 57564 chromosome_1_g_5 3542_Streptococcus_pyogenes_strain_NCTC8198_(—) 57565 chromosome_1_g_1 3542_Streptococcus_pyogenes_strain_NCTC8198_(—) 57566 chromosome_1_g_2 3542_Streptococcus_pyogenes_strain_NCTC8198_(—) 57567 chromosome_1_g_3 3542_Streptococcus_pyogenes_strain_NCTC8198_(—) 57568 chromosome_1_g_4 3542_Streptococcus_pyogenes_strain_NCTC8198_(—) 57569 chromosome_1_g_5 3543_Streptococcus_pyogenes_strain_NCTC8198_(—) 57570 chromosome_1_g_1 3543_Streptococcus_pyogenes_strain_NCTC8198_(—) 57571 chromosome_1_g_2 3543_Streptococcus_pyogenes_strain_NCTC8198_(—) 57572 chromosome_1_g_3 3543_Streptococcus_pyogenes_strain_NCTC8198_(—) 57573 chromosome_1_g_4 3543_Streptococcus_pyogenes_strain_NCTC8198_(—) 57574 chromosome_1_g_5 3544_Streptococcus_pyogenes_strain_NCTC8198_(—) 57575 chromosome_1_g_1 3544_Streptococcus_pyogenes_strain_NCTC8198_(—) 57576 chromosome_1_g_2 3544_Streptococcus_pyogenes_strain_NCTC8198_(—) 57577 chromosome_1_g_3 3544_Streptococcus_pyogenes_strain_NCTC8198_(—) 57578 chromosome_1_g_4 3544_Streptococcus_pyogenes_strain_NCTC8198_(—) 57579 chromosome_1_g_5 3545_Streptococcus_pyogenes_strain_NCTC8198_(—) 57580 chromosome_1_g_1 3545_Streptococcus_pyogenes_strain_NCTC8198_(—) 57581 chromosome_1_g_2 3545_Streptococcus_pyogenes_strain_NCTC8198_(—) 57582 chromosome_1_g_3 3545_Streptococcus_pyogenes_strain_NCTC8198_(—) 57583 chromosome_1_g_4 3545_Streptococcus_pyogenes_strain_NCTC8198_(—) 57584 chromosome_1_g_5 3546_Streptococcus_pyogenes_strain_NCTC8198_(—) 57585 chromosome_1_g_1 3546_Streptococcus_pyogenes_strain_NCTC8198_(—) 57586 chromosome_1_g_2 3546_Streptococcus_pyogenes_strain_NCTC8198_(—) 57587 chromosome_1_g_3 3546_Streptococcus_pyogenes_strain_NCTC8198_(—) 57588 chromosome_1_g_4 3546_Streptococcus_pyogenes_strain_NCTC8198_(—) 57589 chromosome_1_g_5 3547_Streptococcus_pyogenes_strain_NCTC8198_(—) 57590 chromosome_1_g_1 3547_Streptococcus_pyogenes_strain_NCTC8198_(—) 57591 chromosome_1_g_2 3547_Streptococcus_pyogenes_strain_NCTC8198_(—) 57592 chromosome_1_g_3 3547_Streptococcus_pyogenes_strain_NCTC8198_(—) 57593 chromosome_1_g_4 3547_Streptococcus_pyogenes_strain_NCTC8198_(—) 57594 chromosome_1_g_5 3548_Streptococcus_pyogenes_strain_NCTC8198_(—) 57595 chromosome_1_g_1 3548_Streptococcus_pyogenes_strain_NCTC8198_(—) 57596 chromosome_1_g_2 3548_Streptococcus_pyogenes_strain_NCTC8198_(—) 57597 chromosome_1_g_3 3548_Streptococcus_pyogenes_strain_NCTC8198_(—) 57598 chromosome_1_g_4 3548_Streptococcus_pyogenes_strain_NCTC8198_(—) 57599 chromosome_1_g_5 3549_Streptococcus_pyogenes_strain_NCTC8198_(—) 57600 chromosome_1_g_1 3549_Streptococcus_pyogenes_strain_NCTC8198_(—) 57601 chromosome_1_g_2 3549_Streptococcus_pyogenes_strain_NCTC8198_(—) 57602 chromosome_1_g_3 3549_Streptococcus_pyogenes_strain_NCTC8198_(—) 57603 chromosome_1_g_4 3549_Streptococcus_pyogenes_strain_NCTC8198_(—) 57604 chromosome_1_g_5 3550_Streptococcus_pyogenes_strain_NCTC8198_(—) 57605 chromosome_1_g_1 3550_Streptococcus_pyogenes_strain_NCTC8198_(—) 57606 chromosome_1_g_2 3550_Streptococcus_pyogenes_strain_NCTC8198_(—) 57607 chromosome_1_g_3 3550_Streptococcus_pyogenes_strain_NCTC8198_(—) 57608 chromosome_1_g_4 3550_Streptococcus_pyogenes_strain_NCTC8198_(—) 57609 chromosome_1_g_5 3551_Streptococcus_pyogenes_strain_NCTC8198_(—) 57610 chromosome_1_g_1 3551_Streptococcus_pyogenes_strain_NCTC8198_(—) 57611 chromosome_1_g_2 3551_Streptococcus_pyogenes_strain_NCTC8198_(—) 57612 chromosome_1_g_3 3551_Streptococcus_pyogenes_strain_NCTC8198_(—) 57613 chromosome_1_g_4 3551_Streptococcus_pyogenes_strain_NCTC8198_(—) 57614 chromosome_1_g_5 3552_Streptococcus_pyogenes_strain_NCTC8198_(—) 57615 chromosome_1_g_1 3552_Streptococcus_pyogenes_strain_NCTC8198_(—) 57616 chromosome_1_g_2 3552_Streptococcus_pyogenes_strain_NCTC8198_(—) 57617 chromosome_1_g_3 3552_Streptococcus_pyogenes_strain_NCTC8198_(—) 57618 chromosome_1_g_4 3552_Streptococcus_pyogenes_strain_NCTC8198_(—) 57619 chromosome_1_g_5 3553_Streptococcus_pyogenes_strain_NCTC8198_(—) 57620 chromosome_1_g_1 3553_Streptococcus_pyogenes_strain_NCTC8198_(—) 57621 chromosome_1_g_2 3553_Streptococcus_pyogenes_strain_NCTC8198_(—) 57622 chromosome_1_g_3 3553_Streptococcus_pyogenes_strain_NCTC8198_(—) 57623 chromosome_1_g_4 3553_Streptococcus_pyogenes_strain_NCTC8198_(—) 57624 chromosome_1_g_5 3554_Streptococcus_pyogenes_strain_NCTC8198_(—) 57625 chromosome_1_g_1 3554_Streptococcus_pyogenes_strain_NCTC8198_(—) 57626 chromosome_1_g_2 3554_Streptococcus_pyogenes_strain_NCTC8198_(—) 57627 chromosome_1_g_3 3554_Streptococcus_pyogenes_strain_NCTC8198_(—) 57628 chromosome_1_g_4 3554_Streptococcus_pyogenes_strain_NCTC8198_(—) 57629 chromosome_1_g_5 3555_Streptococcus_pyogenes_strain_NCTC8198_(—) 57630 chromosome_1_g_1 3555_Streptococcus_pyogenes_strain_NCTC8198_(—) 57631 chromosome_1_g_2 3555_Streptococcus_pyogenes_strain_NCTC8198_(—) 57632 chromosome_1_g_3 3555_Streptococcus_pyogenes_strain_NCTC8198_(—) 57633 chromosome_1_g_4 3555_Streptococcus_pyogenes_strain_NCTC8198_(—) 57634 chromosome_1_g_5 3556_Streptococcus_pyogenes_strain_NCTC8198_(—) 57635 chromosome_1_g_1 3556_Streptococcus_pyogenes_strain_NCTC8198_(—) 57636 chromosome_1_g_2 3556_Streptococcus_pyogenes_strain_NCTC8198_(—) 57637 chromosome_1_g_3 3556_Streptococcus_pyogenes_strain_NCTC8198_(—) 57638 chromosome_1_g_4 3556_Streptococcus_pyogenes_strain_NCTC8198_(—) 57639 chromosome_1_g_5 3557_Streptococcus_pyogenes_strain_NCTC8198_(—) 57640 chromosome_1_g_1 3557_Streptococcus_pyogenes_strain_NCTC8198_(—) 57641 chromosome_1_g_2 3557_Streptococcus_pyogenes_strain_NCTC8198_(—) 57642 chromosome_1_g_3 3557_Streptococcus_pyogenes_strain_NCTC8198_(—) 57643 chromosome_1_g_4 3557_Streptococcus_pyogenes_strain_NCTC8198_(—) 57644 chromosome_1_g_5 3558_Streptococcus_pyogenes_strain_NCTC8198_(—) 57645 chromosome_1_g_1 3558_Streptococcus_pyogenes_strain_NCTC8198_(—) 57646 chromosome_1_g_2 3558_Streptococcus_pyogenes_strain_NCTC8198_(—) 57647 chromosome_1_g_3 3558_Streptococcus_pyogenes_strain_NCTC8198_(—) 57648 chromosome_1_g_4 3558_Streptococcus_pyogenes_strain_NCTC8198_(—) 57649 chromosome_1_g_5 3559_Streptococcus_pyogenes_strain_NCTC8198_(—) 57650 chromosome_1_g_1 3559_Streptococcus_pyogenes_strain_NCTC8198_(—) 57651 chromosome_1_g_2 3559_Streptococcus_pyogenes_strain_NCTC8198_(—) 57652 chromosome_1_g_3 3559_Streptococcus_pyogenes_strain_NCTC8198_(—) 57653 chromosome_1_g_4 3559_Streptococcus_pyogenes_strain_NCTC8198_(—) 57654 chromosome_1_g_5 3560_Streptococcus_pyogenes_strain_NCTC8198_(—) 57655 chromosome_1_g_1 3560_Streptococcus_pyogenes_strain_NCTC8198_(—) 57656 chromosome_1_g_2 3560_Streptococcus_pyogenes_strain_NCTC8198_(—) 57657 chromosome_1_g_3 3560_Streptococcus_pyogenes_strain_NCTC8198_(—) 57658 chromosome_1_g_4 3560_Streptococcus_pyogenes_strain_NCTC8198_(—) 57659 chromosome_1_g_5 3561_Streptococcus_pyogenes_strain_NCTC8198_(—) 57660 chromosome_1_g_1 3561_Streptococcus_pyogenes_strain_NCTC8198_(—) 57661 chromosome_1_g_2 3561_Streptococcus_pyogenes_strain_NCTC8198_(—) 57662 chromosome_1_g_3 3561_Streptococcus_pyogenes_strain_NCTC8198_(—) 57663 chromosome_1_g_4 3561_Streptococcus_pyogenes_strain_NCTC8198_(—) 57664 chromosome_1_g_5 3562_Streptococcus_pyogenes_strain_NCTC8198_(—) 57665 chromosome_1_g_1 3562_Streptococcus_pyogenes_strain_NCTC8198_(—) 57666 chromosome_1_g_2 3562_Streptococcus_pyogenes_strain_NCTC8198_(—) 57667 chromosome_1_g_3 3562_Streptococcus_pyogenes_strain_NCTC8198_(—) 57668 chromosome_1_g_4 3562_Streptococcus_pyogenes_strain_NCTC8198_(—) 57669 chromosome_1_g_5 3563_Streptococcus_pyogenes_strain_NCTC8198_(—) 57670 chromosome_1_g_1 3563_Streptococcus_pyogenes_strain_NCTC8198_(—) 57671 chromosome_1_g_2 3563_Streptococcus_pyogenes_strain_NCTC8198_(—) 57672 chromosome_1_g_3 3563_Streptococcus_pyogenes_strain_NCTC8198_(—) 57673 chromosome_1_g_4 3563_Streptococcus_pyogenes_strain_NCTC8198_(—) 57674 chromosome_1_g_5 3564_Streptococcus_pyogenes_strain_NCTC8198_(—) 57675 chromosome_1_g_1 3564_Streptococcus_pyogenes_strain_NCTC8198_(—) 57676 chromosome_1_g_2 3564_Streptococcus_pyogenes_strain_NCTC8198_(—) 57677 chromosome_1_g_3 3564_Streptococcus_pyogenes_strain_NCTC8198_(—) 57678 chromosome_1_g_4 3564_Streptococcus_pyogenes_strain_NCTC8198_(—) 57679 chromosome_1_g_5 3565_Streptococcus_pyogenes_strain_NCTC8198_(—) 57680 chromosome_1_g_1 3565_Streptococcus_pyogenes_strain_NCTC8198_(—) 57681 chromosome_1_g_2 3565_Streptococcus_pyogenes_strain_NCTC8198_(—) 57682 chromosome_1_g_3 3565_Streptococcus_pyogenes_strain_NCTC8198_(—) 57683 chromosome_1_g_4 3565_Streptococcus_pyogenes_strain_NCTC8198_(—) 57684 chromosome_1_g_5 3566_Streptococcus_pyogenes_strain_NCTC8198_(—) 57685 chromosome_1_g_1 3566_Streptococcus_pyogenes_strain_NCTC8198_(—) 57686 chromosome_1_g_2 3566_Streptococcus_pyogenes_strain_NCTC8198_(—) 57687 chromosome_1_g_3 3566_Streptococcus_pyogenes_strain_NCTC8198_(—) 57688 chromosome_1_g_4 3566_Streptococcus_pyogenes_strain_NCTC8198_(—) 57689 chromosome_1_g_5 3567_Streptococcus_pyogenes_strain_NCTC8198_(—) 57690 chromosome_1_g_1 3567_Streptococcus_pyogenes_strain_NCTC8198_(—) 57691 chromosome_1_g_2 3567_Streptococcus_pyogenes_strain_NCTC8198_(—) 57692 chromosome_1_g_3 3567_Streptococcus_pyogenes_strain_NCTC8198_(—) 57693 chromosome_1_g_4 3567_Streptococcus_pyogenes_strain_NCTC8198_(—) 57694 chromosome_1_g_5 3568_Streptococcus_pyogenes_strain_NCTC8198_(—) 57695 chromosome_1_g_1 3568_Streptococcus_pyogenes_strain_NCTC8198_(—) 57696 chromosome_1_g_2 3568_Streptococcus_pyogenes_strain_NCTC8198_(—) 57697 chromosome_1_g_3 3568_Streptococcus_pyogenes_strain_NCTC8198_(—) 57698 chromosome_1_g_4 3568_Streptococcus_pyogenes_strain_NCTC8198_(—) 57699 chromosome_1_g_5 3569_Streptococcus_pyogenes_strain_NCTC8198_(—) 57700 chromosome_1_g_1 3569_Streptococcus_pyogenes_strain_NCTC8198_(—) 57701 chromosome_1_g_2 3569_Streptococcus_pyogenes_strain_NCTC8198_(—) 57702 chromosome_1_g_3 3569_Streptococcus_pyogenes_strain_NCTC8198_(—) 57703 chromosome_1_g_4 3569_Streptococcus_pyogenes_strain_NCTC8198_(—) 57704 chromosome_1_g_5 3570_Streptococcus_pyogenes_strain_NCTC8198_(—) 57705 chromosome_1_g_1 3570_Streptococcus_pyogenes_strain_NCTC8198_(—) 57706 chromosome_1_g_2 3570_Streptococcus_pyogenes_strain_NCTC8198_(—) 57707 chromosome_1_g_3 3570_Streptococcus_pyogenes_strain_NCTC8198_(—) 57708 chromosome_1_g_4 3570_Streptococcus_pyogenes_strain_NCTC8198_(—) 57709 chromosome_1_g_5 3571_Streptococcus_pyogenes_strain_NCTC8198_(—) 57710 chromosome_1_g_1 3571_Streptococcus_pyogenes_strain_NCTC8198_(—) 57711 chromosome_1_g_2 3571_Streptococcus_pyogenes_strain_NCTC8198_(—) 57712 chromosome_1_g_3 3571_Streptococcus_pyogenes_strain_NCTC8198_(—) 57713 chromosome_1_g_4 3571_Streptococcus_pyogenes_strain_NCTC8198_(—) 57714 chromosome_1_g_5 3572_Streptococcus_pyogenes_strain_NCTC8198_(—) 57715 chromosome_1_g_1 3572_Streptococcus_pyogenes_strain_NCTC8198_(—) 57716 chromosome_1_g_2 3572_Streptococcus_pyogenes_strain_NCTC8198_(—) 57717 chromosome_1_g_3 3572_Streptococcus_pyogenes_strain_NCTC8198_(—) 57718 chromosome_1_g_4 3572_Streptococcus_pyogenes_strain_NCTC8198_(—) 57719 chromosome_1_g_5 3573_Streptococcus_pyogenes_strain_NCTC8198_(—) 57720 chromosome_1_g_1 3573_Streptococcus_pyogenes_strain_NCTC8198_(—) 57721 chromosome_1_g_2 3573_Streptococcus_pyogenes_strain_NCTC8198_(—) 57722 chromosome_1_g_3 3573_Streptococcus_pyogenes_strain_NCTC8198_(—) 57723 chromosome_1_g_4 3573_Streptococcus_pyogenes_strain_NCTC8198_(—) 57724 chromosome_1_g_5 3574_Streptococcus_pyogenes_strain_NCTC8198_(—) 57725 chromosome_1_g_1 3574_Streptococcus_pyogenes_strain_NCTC8198_(—) 57726 chromosome_1_g_2 3574_Streptococcus_pyogenes_strain_NCTC8198_(—) 57727 chromosome_1_g_3 3574_Streptococcus_pyogenes_strain_NCTC8198_(—) 57728 chromosome_1_g_4 3574_Streptococcus_pyogenes_strain_NCTC8198_(—) 57729 chromosome_1_g_5 3575_Streptococcus_pyogenes_strain_NCTC8198_(—) 57730 chromosome_1_g_1 3575_Streptococcus_pyogenes_strain_NCTC8198_(—) 57731 chromosome_1_g_2 3575_Streptococcus_pyogenes_strain_NCTC8198_(—) 57732 chromosome_1_g_3 3575_Streptococcus_pyogenes_strain_NCTC8198_(—) 57733 chromosome_1_g_4 3575_Streptococcus_pyogenes_strain_NCTC8198_(—) 57734 chromosome_1_g_5 3576_Streptococcus_pyogenes_strain_NCTC8198_(—) 57735 chromosome_1_g_1 3576_Streptococcus_pyogenes_strain_NCTC8198_(—) 57736 chromosome_1_g_2 3576_Streptococcus_pyogenes_strain_NCTC8198_(—) 57737 chromosome_1_g_3 3576_Streptococcus_pyogenes_strain_NCTC8198_(—) 57738 chromosome_1_g_4 3576_Streptococcus_pyogenes_strain_NCTC8198_(—) 57739 chromosome_1_g_5 3577_Streptococcus_pyogenes_strain_NCTC8198_(—) 57740 chromosome_1_g_1 3577_Streptococcus_pyogenes_strain_NCTC8198_(—) 57741 chromosome_1_g_2 3577_Streptococcus_pyogenes_strain_NCTC8198_(—) 57742 chromosome_1_g_3 3577_Streptococcus_pyogenes_strain_NCTC8198_(—) 57743 chromosome_1_g_4 3577_Streptococcus_pyogenes_strain_NCTC8198_(—) 57744 chromosome_1_g_5 3578_Streptococcus_pyogenes_strain_NCTC8198_(—) 57745 chromosome_1_g_1 3578_Streptococcus_pyogenes_strain_NCTC8198_(—) 57746 chromosome_1_g_2 3578_Streptococcus_pyogenes_strain_NCTC8198_(—) 57747 chromosome_1_g_3 3578_Streptococcus_pyogenes_strain_NCTC8198_(—) 57748 chromosome_1_g_4 3578_Streptococcus_pyogenes_strain_NCTC8198_(—) 57749 chromosome_1_g_5 3579_Streptococcus_pyogenes_strain_NCTC8198_(—) 57750 chromosome_1_g_1 3579_Streptococcus_pyogenes_strain_NCTC8198_(—) 57751 chromosome_1_g_2 3579_Streptococcus_pyogenes_strain_NCTC8198_(—) 57752 chromosome_1_g_3 3579_Streptococcus_pyogenes_strain_NCTC8198_(—) 57753 chromosome_1_g_4 3579_Streptococcus_pyogenes_strain_NCTC8198_(—) 57754 chromosome_1_g_5 3580_Streptococcus_pyogenes_strain_NCTC8198_(—) 57755 chromosome_1_g_1 3580_Streptococcus_pyogenes_strain_NCTC8198_(—) 57756 chromosome_1_g_2 3580_Streptococcus_pyogenes_strain_NCTC8198_(—) 57757 chromosome_1_g_3 3580_Streptococcus_pyogenes_strain_NCTC8198_(—) 57758 chromosome_1_g_4 3580_Streptococcus_pyogenes_strain_NCTC8198_(—) 57759 chromosome_1_g_5 3581_Streptococcus_pyogenes_strain_NCTC8198_(—) 57760 chromosome_1_g_1 3581_Streptococcus_pyogenes_strain_NCTC8198_(—) 57761 chromosome_1_g_2 3581_Streptococcus_pyogenes_strain_NCTC8198_(—) 57762 chromosome_1_g_3 3581_Streptococcus_pyogenes_strain_NCTC8198_(—) 57763 chromosome_1_g_4 3581_Streptococcus_pyogenes_strain_NCTC8198_(—) 57764 chromosome_1_g_5 3582_Streptococcus_pyogenes_strain_NCTC8198_(—) 57765 chromosome_1_g_1 3582_Streptococcus_pyogenes_strain_NCTC8198_(—) 57766 chromosome_1_g_2 3582_Streptococcus_pyogenes_strain_NCTC8198_(—) 57767 chromosome_1_g_3 3582_Streptococcus_pyogenes_strain_NCTC8198_(—) 57768 chromosome_1_g_4 3582_Streptococcus_pyogenes_strain_NCTC8198_(—) 57769 chromosome_1_g_5 3583_Streptococcus_pyogenes_strain_NCTC8198_(—) 57770 chromosome_1_g_1 3583_Streptococcus_pyogenes_strain_NCTC8198_(—) 57771 chromosome_1_g_2 3583_Streptococcus_pyogenes_strain_NCTC8198_(—) 57772 chromosome_1_g_3 3583_Streptococcus_pyogenes_strain_NCTC8198_(—) 57773 chromosome_1_g_4 3583_Streptococcus_pyogenes_strain_NCTC8198_(—) 57774 chromosome_1_g_5 3584_Streptococcus_pyogenes_strain_NCTC8198_(—) 57775 chromosome_1_g_1 3584_Streptococcus_pyogenes_strain_NCTC8198_(—) 57776 chromosome_1_g_2 3584_Streptococcus_pyogenes_strain_NCTC8198_(—) 57777 chromosome_1_g_3 3584_Streptococcus_pyogenes_strain_NCTC8198_(—) 57778 chromosome_1_g_4 3584_Streptococcus_pyogenes_strain_NCTC8198_(—) 57779 chromosome_1_g_5 3585_Streptococcus_pyogenes_strain_NCTC8198_(—) 57780 chromosome_1_g_1 3585_Streptococcus_pyogenes_strain_NCTC8198_(—) 57781 chromosome_1_g_2 3585_Streptococcus_pyogenes_strain_NCTC8198_(—) 57782 chromosome_1_g_3 3585_Streptococcus_pyogenes_strain_NCTC8198_(—) 57783 chromosome_1_g_4 3585_Streptococcus_pyogenes_strain_NCTC8198_(—) 57784 chromosome_1_g_5 3586_Streptococcus_pyogenes_strain_NCTC8198_(—) 57785 chromosome_1_g_1 3586_Streptococcus_pyogenes_strain_NCTC8198_(—) 57786 chromosome_1_g_2 3586_Streptococcus_pyogenes_strain_NCTC8198_(—) 57787 chromosome_1_g_3 3586_Streptococcus_pyogenes_strain_NCTC8198_(—) 57788 chromosome_1_g_4 3586_Streptococcus_pyogenes_strain_NCTC8198_(—) 57789 chromosome_1_g_5 3587_Streptococcus_pyogenes_strain_NCTC8198_(—) 57790 chromosome_1_g_1 3587_Streptococcus_pyogenes_strain_NCTC8198_(—) 57791 chromosome_1_g_2 3587_Streptococcus_pyogenes_strain_NCTC8198_(—) 57792 chromosome_1_g_3 3587_Streptococcus_pyogenes_strain_NCTC8198_(—) 57793 chromosome_1_g_4 3587_Streptococcus_pyogenes_strain_NCTC8198_(—) 57794 chromosome_1_g_5 3588_Streptococcus_pyogenes_strain_NCTC8198_(—) 57795 chromosome_1_g_1 3588_Streptococcus_pyogenes_strain_NCTC8198_(—) 57796 chromosome_1_g_2 3588_Streptococcus_pyogenes_strain_NCTC8198_(—) 57797 chromosome_1_g_3 3588_Streptococcus_pyogenes_strain_NCTC8198_(—) 57798 chromosome_1_g_4 3588_Streptococcus_pyogenes_strain_NCTC8198_(—) 57799 chromosome_1_g_5 3589_Streptococcus_pyogenes_strain_NCTC8198_(—) 57800 chromosome_1_g_1 3589_Streptococcus_pyogenes_strain_NCTC8198_(—) 57801 chromosome_1_g_2 3589_Streptococcus_pyogenes_strain_NCTC8198_(—) 57802 chromosome_1_g_3 3589_Streptococcus_pyogenes_strain_NCTC8198_(—) 57803 chromosome_1_g_4 3589_Streptococcus_pyogenes_strain_NCTC8198_(—) 57804 chromosome_1_g_5 3590_Streptococcus_pyogenes_strain_NCTC8198_(—) 57805 chromosome_1_g_1 3590_Streptococcus_pyogenes_strain_NCTC8198_(—) 57806 chromosome_1_g_2 3590_Streptococcus_pyogenes_strain_NCTC8198_(—) 57807 chromosome_1_g_3 3590_Streptococcus_pyogenes_strain_NCTC8198_(—) 57808 chromosome_1_g_4 3590_Streptococcus_pyogenes_strain_NCTC8198_(—) 57809 chromosome_1_g_5 3591_Streptococcus_pyogenes_strain_NCTC8198_(—) 57810 chromosome_1_g_1 3591_Streptococcus_pyogenes_strain_NCTC8198_(—) 57811 chromosome_1_g_2 3591_Streptococcus_pyogenes_strain_NCTC8198_(—) 57812 chromosome_1_g_3 3591_Streptococcus_pyogenes_strain_NCTC8198_(—) 57813 chromosome_1_g_4 3591_Streptococcus_pyogenes_strain_NCTC8198_(—) 57814 chromosome_1_g_5 3592_Streptococcus_pyogenes_strain_NCTC8198_(—) 57815 chromosome_1_g_1 3592_Streptococcus_pyogenes_strain_NCTC8198_(—) 57816 chromosome_1_g_2 3592_Streptococcus_pyogenes_strain_NCTC8198_(—) 57817 chromosome_1_g_3 3592_Streptococcus_pyogenes_strain_NCTC8198_(—) 57818 chromosome_1_g_4 3592_Streptococcus_pyogenes_strain_NCTC8198_(—) 57819 chromosome_1_g_5 3593_Streptococcus_pyogenes_strain_NCTC8198_(—) 57820 chromosome_1_g_1 3593_Streptococcus_pyogenes_strain_NCTC8198_(—) 57821 chromosome_1_g_2 3593_Streptococcus_pyogenes_strain_NCTC8198_(—) 57822 chromosome_1_g_3 3593_Streptococcus_pyogenes_strain_NCTC8198_(—) 57823 chromosome_1_g_4 3593_Streptococcus_pyogenes_strain_NCTC8198_(—) 57824 chromosome_1_g_5 3594_Streptococcus_pyogenes_strain_NCTC8198_(—) 57825 chromosome_1_g_1 3594_Streptococcus_pyogenes_strain_NCTC8198_(—) 57826 chromosome_1_g_2 3594_Streptococcus_pyogenes_strain_NCTC8198_(—) 57827 chromosome_1_g_3 3594_Streptococcus_pyogenes_strain_NCTC8198_(—) 57828 chromosome_1_g_4 3594_Streptococcus_pyogenes_strain_NCTC8198_(—) 57829 chromosome_1_g_5 3595_Streptococcus_pyogenes_strain_NCTC8198_(—) 57830 chromosome_1_g_1 3595_Streptococcus_pyogenes_strain_NCTC8198_(—) 57831 chromosome_1_g_2 3595_Streptococcus_pyogenes_strain_NCTC8198_(—) 57832 chromosome_1_g_3 3595_Streptococcus_pyogenes_strain_NCTC8198_(—) 57833 chromosome_1_g_4 3595_Streptococcus_pyogenes_strain_NCTC8198_(—) 57834 chromosome_1_g_5 3596_Streptococcus_pyogenes_strain_NCTC8198_(—) 57835 chromosome_1_g_1 3596_Streptococcus_pyogenes_strain_NCTC8198_(—) 57836 chromosome_1_g_2 3596_Streptococcus_pyogenes_strain_NCTC8198_(—) 57837 chromosome_1_g_3 3596_Streptococcus_pyogenes_strain_NCTC8198_(—) 57838 chromosome_1_g_4 3596_Streptococcus_pyogenes_strain_NCTC8198_(—) 57839 chromosome_1_g_5 3597_Streptococcus_pyogenes_strain_NCTC8198_(—) 57840 chromosome_1_g_1 3597_Streptococcus_pyogenes_strain_NCTC8198_(—) 57841 chromosome_1_g_2 3597_Streptococcus_pyogenes_strain_NCTC8198_(—) 57842 chromosome_1_g_3 3597_Streptococcus_pyogenes_strain_NCTC8198_(—) 57843 chromosome_1_g_4 3597_Streptococcus_pyogenes_strain_NCTC8198_(—) 57844 chromosome_1_g_5 3598_Streptococcus_pyogenes_strain_NCTC8198_(—) 57845 chromosome_1_g_1 3598_Streptococcus_pyogenes_strain_NCTC8198_(—) 57846 chromosome_1_g_2 3598_Streptococcus_pyogenes_strain_NCTC8198_(—) 57847 chromosome_1_g_3 3598_Streptococcus_pyogenes_strain_NCTC8198_(—) 57848 chromosome_1_g_4 3598_Streptococcus_pyogenes_strain_NCTC8198_(—) 57849 chromosome_1_g_5 3599_Streptococcus_pyogenes_strain_NCTC8198_(—) 57850 chromosome_1_g_1 3599_Streptococcus_pyogenes_strain_NCTC8198_(—) 57851 chromosome_1_g_2 3599_Streptococcus_pyogenes_strain_NCTC8198_(—) 57852 chromosome_1_g_3 3599_Streptococcus_pyogenes_strain_NCTC8198_(—) 57853 chromosome_1_g_4 3599_Streptococcus_pyogenes_strain_NCTC8198_(—) 57854 chromosome_1_g_5 3600_Streptococcus_pyogenes_strain_NCTC8198_(—) 57855 chromosome_1_g_1 3600_Streptococcus_pyogenes_strain_NCTC8198_(—) 57856 chromosome_1_g_2 3600_Streptococcus_pyogenes_strain_NCTC8198_(—) 57857 chromosome_1_g_3 3600_Streptococcus_pyogenes_strain_NCTC8198_(—) 57858 chromosome_1_g_4 3600_Streptococcus_pyogenes_strain_NCTC8198_(—) 57859 chromosome_1_g_5 3601_Streptococcus_pyogenes_strain_NCTC8198_(—) 57860 chromosome_1_g_1 3601_Streptococcus_pyogenes_strain_NCTC8198_(—) 57861 chromosome_1_g_2 3601_Streptococcus_pyogenes_strain_NCTC8198_(—) 57862 chromosome_1_g_3 3601_Streptococcus_pyogenes_strain_NCTC8198_(—) 57863 chromosome_1_g_4 3601_Streptococcus_pyogenes_strain_NCTC8198_(—) 57864 chromosome_1_g_5 3602_Streptococcus_pyogenes_strain_NCTC8198_(—) 57865 chromosome_1_g_1 3602_Streptococcus_pyogenes_strain_NCTC8198_(—) 57866 chromosome_1_g_2 3602_Streptococcus_pyogenes_strain_NCTC8198_(—) 57867 chromosome_1_g_3 3602_Streptococcus_pyogenes_strain_NCTC8198_(—) 57868 chromosome_1_g_4 3602_Streptococcus_pyogenes_strain_NCTC8198_(—) 57869 chromosome_1_g_5 3603_Streptococcus_pyogenes_strain_NCTC8198_(—) 57870 chromosome_1_g_1 3603_Streptococcus_pyogenes_strain_NCTC8198_(—) 57871 chromosome_1_g_2 3603_Streptococcus_pyogenes_strain_NCTC8198_(—) 57872 chromosome_1_g_3 3603_Streptococcus_pyogenes_strain_NCTC8198_(—) 57873 chromosome_1_g_4 3603_Streptococcus_pyogenes_strain_NCTC8198_(—) 57874 chromosome_1_g_5 3604_Streptococcus_pyogenes_strain_NCTC8198_(—) 57875 chromosome_1_g_1 3604_Streptococcus_pyogenes_strain_NCTC8198_(—) 57876 chromosome_1_g_2 3604_Streptococcus_pyogenes_strain_NCTC8198_(—) 57877 chromosome_1_g_3 3604_Streptococcus_pyogenes_strain_NCTC8198_(—) 57878 chromosome_1_g_4 3604_Streptococcus_pyogenes_strain_NCTC8198_(—) 57879 chromosome_1_g_5 3605_Streptococcus_pyogenes_strain_NCTC8198_(—) 57880 chromosome_1_g_1 3605_Streptococcus_pyogenes_strain_NCTC8198_(—) 57881 chromosome_1_g_2 3605_Streptococcus_pyogenes_strain_NCTC8198_(—) 57882 chromosome_1_g_3 3605_Streptococcus_pyogenes_strain_NCTC8198_(—) 57883 chromosome_1_g_4 3605_Streptococcus_pyogenes_strain_NCTC8198_(—) 57884 chromosome_1_g_5 3606_Streptococcus_pyogenes_strain_NCTC8198_(—) 57885 chromosome_1_g_1 3606_Streptococcus_pyogenes_strain_NCTC8198_(—) 57886 chromosome_1_g_2 3606_Streptococcus_pyogenes_strain_NCTC8198_(—) 57887 chromosome_1_g_3 3606_Streptococcus_pyogenes_strain_NCTC8198_(—) 57888 chromosome_1_g_4 3606_Streptococcus_pyogenes_strain_NCTC8198_(—) 57889 chromosome_1_g_5 3607_Streptococcus_pyogenes_strain_NCTC8198_(—) 57890 chromosome_1_g_1 3607_Streptococcus_pyogenes_strain_NCTC8198_(—) 57891 chromosome_1_g_2 3607_Streptococcus_pyogenes_strain_NCTC8198_(—) 57892 chromosome_1_g_3 3607_Streptococcus_pyogenes_strain_NCTC8198_(—) 57893 chromosome_1_g_4 3607_Streptococcus_pyogenes_strain_NCTC8198_(—) 57894 chromosome_1_g_5 3608_Streptococcus_pyogenes_strain_NCTC8198_(—) 57895 chromosome_1_g_1 3608_Streptococcus_pyogenes_strain_NCTC8198_(—) 57896 chromosome_1_g_2 3608_Streptococcus_pyogenes_strain_NCTC8198_(—) 57897 chromosome_1_g_3 3608_Streptococcus_pyogenes_strain_NCTC8198_(—) 57898 chromosome_1_g_4 3608_Streptococcus_pyogenes_strain_NCTC8198_(—) 57899 chromosome_1_g_5 3609_Streptococcus_pyogenes_strain_NCTC8198_(—) 57900 chromosome_1_g_1 3609_Streptococcus_pyogenes_strain_NCTC8198_(—) 57901 chromosome_1_g_2 3609_Streptococcus_pyogenes_strain_NCTC8198_(—) 57902 chromosome_1_g_3 3609_Streptococcus_pyogenes_strain_NCTC8198_(—) 57903 chromosome_1_g_4 3609_Streptococcus_pyogenes_strain_NCTC8198_(—) 57904 chromosome_1_g_5 3610_Streptococcus_pyogenes_strain_NCTC8198_(—) 57905 chromosome_1_g_1 3610_Streptococcus_pyogenes_strain_NCTC8198_(—) 57906 chromosome_1_g_2 3610_Streptococcus_pyogenes_strain_NCTC8198_(—) 57907 chromosome_1_g_3 3610_Streptococcus_pyogenes_strain_NCTC8198_(—) 57908 chromosome_1_g_4 3610_Streptococcus_pyogenes_strain_NCTC8198_(—) 57909 chromosome_1_g_5 3611_Streptococcus_pyogenes_strain_NCTC8198_(—) 57910 chromosome_1_g_1 3611_Streptococcus_pyogenes_strain_NCTC8198_(—) 57911 chromosome_1_g_2 3611_Streptococcus_pyogenes_strain_NCTC8198_(—) 57912 chromosome_1_g_3 3611_Streptococcus_pyogenes_strain_NCTC8198_(—) 57913 chromosome_1_g_4 3611_Streptococcus_pyogenes_strain_NCTC8198_(—) 57914 chromosome_1_g_5 3612_Streptococcus_pyogenes_strain_NCTC8198_(—) 57915 chromosome_1_g_1 3612_Streptococcus_pyogenes_strain_NCTC8198_(—) 57916 chromosome_1_g_2 3612_Streptococcus_pyogenes_strain_NCTC8198_(—) 57917 chromosome_1_g_3 3612_Streptococcus_pyogenes_strain_NCTC8198_(—) 57918 chromosome_1_g_4 3612_Streptococcus_pyogenes_strain_NCTC8198_(—) 57919 chromosome_1_g_5 3613_Streptococcus_pyogenes_strain_NCTC8198_(—) 57920 chromosome_1_g_1 3613_Streptococcus_pyogenes_strain_NCTC8198_(—) 57921 chromosome_1_g_2 3613_Streptococcus_pyogenes_strain_NCTC8198_(—) 57922 chromosome_1_g_3 3613_Streptococcus_pyogenes_strain_NCTC8198_(—) 57923 chromosome_1_g_4 3613_Streptococcus_pyogenes_strain_NCTC8198_(—) 57924 chromosome_1_g_5 3614_Streptococcus_pyogenes_strain_NCTC8198_(—) 57925 chromosome_1_g_1 3614_Streptococcus_pyogenes_strain_NCTC8198_(—) 57926 chromosome_1_g_2 3614_Streptococcus_pyogenes_strain_NCTC8198_(—) 57927 chromosome_1_g_3 3614_Streptococcus_pyogenes_strain_NCTC8198_(—) 57928 chromosome_1_g_4 3614_Streptococcus_pyogenes_strain_NCTC8198_(—) 57929 chromosome_1_g_5 3615_Streptococcus_pyogenes_strain_NCTC8198_(—) 57930 chromosome_1_g_1 3615_Streptococcus_pyogenes_strain_NCTC8198_(—) 57931 chromosome_1_g_2 3615_Streptococcus_pyogenes_strain_NCTC8198_(—) 57932 chromosome_1_g_3 3615_Streptococcus_pyogenes_strain_NCTC8198_(—) 57933 chromosome_1_g_4 3615_Streptococcus_pyogenes_strain_NCTC8198_(—) 57934 chromosome_1_g_5 3616_Streptococcus_pyogenes_strain_NCTC8198_(—) 57935 chromosome_1_g_1 3616_Streptococcus_pyogenes_strain_NCTC8198_(—) 57936 chromosome_1_g_2 3616_Streptococcus_pyogenes_strain_NCTC8198_(—) 57937 chromosome_1_g_3 3616_Streptococcus_pyogenes_strain_NCTC8198_(—) 57938 chromosome_1_g_4 3616_Streptococcus_pyogenes_strain_NCTC8198_(—) 57939 chromosome_1_g_5 3617_Streptococcus_pyogenes_strain_NCTC8198_(—) 57940 chromosome_1_g_1 3617_Streptococcus_pyogenes_strain_NCTC8198_(—) 57941 chromosome_1_g_2 3617_Streptococcus_pyogenes_strain_NCTC8198_(—) 57942 chromosome_1_g_3 3617_Streptococcus_pyogenes_strain_NCTC8198_(—) 57943 chromosome_1_g_4 3617_Streptococcus_pyogenes_strain_NCTC8198_(—) 57944 chromosome_1_g_5 3618_Streptococcus_pyogenes_strain_NCTC8198_(—) 57945 chromosome_1_g_1 3618_Streptococcus_pyogenes_strain_NCTC8198_(—) 57946 chromosome_1_g_2 3618_Streptococcus_pyogenes_strain_NCTC8198_(—) 57947 chromosome_1_g_3 3618_Streptococcus_pyogenes_strain_NCTC8198_(—) 57948 chromosome_1_g_4 3618_Streptococcus_pyogenes_strain_NCTC8198_(—) 57949 chromosome_1_g_5 3619_Streptococcus_pyogenes_strain_NCTC8198_(—) 57950 chromosome_1_g_1 3619_Streptococcus_pyogenes_strain_NCTC8198_(—) 57951 chromosome_1_g_2 3619_Streptococcus_pyogenes_strain_NCTC8198_(—) 57952 chromosome_1_g_3 3619_Streptococcus_pyogenes_strain_NCTC8198_(—) 57953 chromosome_1_g_4 3619_Streptococcus_pyogenes_strain_NCTC8198_(—) 57954 chromosome_1_g_5 3620_Streptococcus_pyogenes_strain_NCTC8198_(—) 57955 chromosome_1_g_1 3620_Streptococcus_pyogenes_strain_NCTC8198_(—) 57956 chromosome_1_g_2 3620_Streptococcus_pyogenes_strain_NCTC8198_(—) 57957 chromosome_1_g_3 3620_Streptococcus_pyogenes_strain_NCTC8198_(—) 57958 chromosome_1_g_4 3620_Streptococcus_pyogenes_strain_NCTC8198_(—) 57959 chromosome_1_g_5 3621_Streptococcus_pyogenes_strain_NCTC8198_(—) 57960 chromosome_1_g_1 3621_Streptococcus_pyogenes_strain_NCTC8198_(—) 57961 chromosome_1_g_2 3621_Streptococcus_pyogenes_strain_NCTC8198_(—) 57962 chromosome_1_g_3 3621_Streptococcus_pyogenes_strain_NCTC8198_(—) 57963 chromosome_1_g_4 3621_Streptococcus_pyogenes_strain_NCTC8198_(—) 57964 chromosome_1_g_5 3622_Streptococcus_pyogenes_strain_NCTC8198_(—) 57965 chromosome_1_g_1 3622_Streptococcus_pyogenes_strain_NCTC8198_(—) 57966 chromosome_1_g_2 3622_Streptococcus_pyogenes_strain_NCTC8198_(—) 57967 chromosome_1_g_3 3622_Streptococcus_pyogenes_strain_NCTC8198_(—) 57968 chromosome_1_g_4 3622_Streptococcus_pyogenes_strain_NCTC8198_(—) 57969 chromosome_1_g_5 3623_Streptococcus_pyogenes_strain_NCTC8198_(—) 57970 chromosome_1_g_1 3623_Streptococcus_pyogenes_strain_NCTC8198_(—) 57971 chromosome_1_g_2 3623_Streptococcus_pyogenes_strain_NCTC8198_(—) 57972 chromosome_1_g_3 3623_Streptococcus_pyogenes_strain_NCTC8198_(—) 57973 chromosome_1_g_4 3623_Streptococcus_pyogenes_strain_NCTC8198_(—) 57974 chromosome_1_g_5 3624_Streptococcus_pyogenes_strain_NCTC8198_(—) 57975 chromosome_1_g_1 3624_Streptococcus_pyogenes_strain_NCTC8198_(—) 57976 chromosome_1_g_2 3624_Streptococcus_pyogenes_strain_NCTC8198_(—) 57977 chromosome_1_g_3 3624_Streptococcus_pyogenes_strain_NCTC8198_(—) 57978 chromosome_1_g_4 3624_Streptococcus_pyogenes_strain_NCTC8198_(—) 57979 chromosome_1_g_5 3625_Streptococcus_pyogenes_strain_NCTC8198_(—) 57980 chromosome_1_g_1 3625_Streptococcus_pyogenes_strain_NCTC8198_(—) 57981 chromosome_1_g_2 3625_Streptococcus_pyogenes_strain_NCTC8198_(—) 57982 chromosome_1_g_3 3625_Streptococcus_pyogenes_strain_NCTC8198_(—) 57983 chromosome_1_g_4 3625_Streptococcus_pyogenes_strain_NCTC8198_(—) 57984 chromosome_1_g_5 3626_Streptococcus_pyogenes_strain_NCTC8198_(—) 57985 chromosome_1_g_1 3626_Streptococcus_pyogenes_strain_NCTC8198_(—) 57986 chromosome_1_g_2 3626_Streptococcus_pyogenes_strain_NCTC8198_(—) 57987 chromosome_1_g_3 3626_Streptococcus_pyogenes_strain_NCTC8198_(—) 57988 chromosome_1_g_4 3626_Streptococcus_pyogenes_strain_NCTC8198_(—) 57989 chromosome_1_g_5 3627_Streptococcus_pyogenes_strain_NCTC8198_(—) 57990 chromosome_1_g_1 3627_Streptococcus_pyogenes_strain_NCTC8198_(—) 57991 chromosome_1_g_2 3627_Streptococcus_pyogenes_strain_NCTC8198_(—) 57992 chromosome_1_g_3 3627_Streptococcus_pyogenes_strain_NCTC8198_(—) 57993 chromosome_1_g_4 3627_Streptococcus_pyogenes_strain_NCTC8198_(—) 57994 chromosome_1_g_5 3628_Streptococcus_pyogenes_strain_NCTC8198_(—) 57995 chromosome_1_g_1 3628_Streptococcus_pyogenes_strain_NCTC8198_(—) 57996 chromosome_1_g_2 3628_Streptococcus_pyogenes_strain_NCTC8198_(—) 57997 chromosome_1_g_3 3628_Streptococcus_pyogenes_strain_NCTC8198_(—) 57998 chromosome_1_g_4 3628_Streptococcus_pyogenes_strain_NCTC8198_(—) 57999 chromosome_1_g_5 3629_Streptococcus_pyogenes_strain_NCTC8198_(—) 58000 chromosome_1_g_1 3629_Streptococcus_pyogenes_strain_NCTC8198_(—) 58001 chromosome_1_g_2 3629_Streptococcus_pyogenes_strain_NCTC8198_(—) 58002 chromosome_1_g_3 3629_Streptococcus_pyogenes_strain_NCTC8198_(—) 58003 chromosome_1_g_4 3629_Streptococcus_pyogenes_strain_NCTC8198_(—) 58004 chromosome_1_g_5 3630_Streptococcus_pyogenes_strain_NCTC8198_(—) 58005 chromosome_1_g_1 3630_Streptococcus_pyogenes_strain_NCTC8198_(—) 58006 chromosome_1_g_2 3630_Streptococcus_pyogenes_strain_NCTC8198_(—) 58007 chromosome_1_g_3 3630_Streptococcus_pyogenes_strain_NCTC8198_(—) 58008 chromosome_1_g_4 3630_Streptococcus_pyogenes_strain_NCTC8198_(—) 58009 chromosome_1_g_5 3631_Streptococcus_pyogenes_strain_NCTC8198_(—) 58010 chromosome_1_g_1 3631_Streptococcus_pyogenes_strain_NCTC8198_(—) 58011 chromosome_1_g_2 3631_Streptococcus_pyogenes_strain_NCTC8198_(—) 58012 chromosome_1_g_3 3631_Streptococcus_pyogenes_strain_NCTC8198_(—) 58013 chromosome_1_g_4 3631_Streptococcus_pyogenes_strain_NCTC8198_(—) 58014 chromosome_1_g_5 3632_Streptococcus_pyogenes_strain_NCTC8198_(—) 58015 chromosome_1_g_1 3632_Streptococcus_pyogenes_strain_NCTC8198_(—) 58016 chromosome_1_g_2 3632_Streptococcus_pyogenes_strain_NCTC8198_(—) 58017 chromosome_1_g_3 3632_Streptococcus_pyogenes_strain_NCTC8198_(—) 58018 chromosome_1_g_4 3632_Streptococcus_pyogenes_strain_NCTC8198_(—) 58019 chromosome_1_g_5 3633_Streptococcus_pyogenes_strain_NCTC8198_(—) 58020 chromosome_1_g_1 3633_Streptococcus_pyogenes_strain_NCTC8198_(—) 58021 chromosome_1_g_2 3633_Streptococcus_pyogenes_strain_NCTC8198_(—) 58022 chromosome_1_g_3 3633_Streptococcus_pyogenes_strain_NCTC8198_(—) 58023 chromosome_1_g_4 3633_Streptococcus_pyogenes_strain_NCTC8198_(—) 58024 chromosome_1_g_5 3634_Streptococcus_pyogenes_strain_NCTC8198_(—) 58025 chromosome_1_g_1 3634_Streptococcus_pyogenes_strain_NCTC8198_(—) 58026 chromosome_1_g_2 3634_Streptococcus_pyogenes_strain_NCTC8198_(—) 58027 chromosome_1_g_3 3634_Streptococcus_pyogenes_strain_NCTC8198_(—) 58028 chromosome_1_g_4 3634_Streptococcus_pyogenes_strain_NCTC8198_(—) 58029 chromosome_1_g_5 3635_Streptococcus_pyogenes_strain_NCTC8198_(—) 58030 chromosome_1_g_1 3635_Streptococcus_pyogenes_strain_NCTC8198_(—) 58031 chromosome_1_g_2 3635_Streptococcus_pyogenes_strain_NCTC8198_(—) 58032 chromosome_1_g_3 3635_Streptococcus_pyogenes_strain_NCTC8198_(—) 58033 chromosome_1_g_4 3635_Streptococcus_pyogenes_strain_NCTC8198_(—) 58034 chromosome_1_g_5 3636_Streptococcus_pyogenes_strain_NCTC8198_(—) 58035 chromosome_1_g_1 3636_Streptococcus_pyogenes_strain_NCTC8198_(—) 58036 chromosome_1_g_2 3636_Streptococcus_pyogenes_strain_NCTC8198_(—) 58037 chromosome_1_g_3 3636_Streptococcus_pyogenes_strain_NCTC8198_(—) 58038 chromosome_1_g_4 3636_Streptococcus_pyogenes_strain_NCTC8198_(—) 58039 chromosome_1_g_5 3637_Streptococcus_pyogenes_strain_NCTC8198_(—) 58040 chromosome_1_g_1 3637_Streptococcus_pyogenes_strain_NCTC8198_(—) 58041 chromosome_1_g_2 3637_Streptococcus_pyogenes_strain_NCTC8198_(—) 58042 chromosome_1_g_3 3637_Streptococcus_pyogenes_strain_NCTC8198_(—) 58043 chromosome_1_g_4 3637_Streptococcus_pyogenes_strain_NCTC8198_(—) 58044 chromosome_1_g_5 3638_Streptococcus_pyogenes_strain_NCTC8198_(—) 58045 chromosome_1_g_1 3638_Streptococcus_pyogenes_strain_NCTC8198_(—) 58046 chromosome_1_g_2 3638_Streptococcus_pyogenes_strain_NCTC8198_(—) 58047 chromosome_1_g_3 3638_Streptococcus_pyogenes_strain_NCTC8198_(—) 58048 chromosome_1_g_4 3638_Streptococcus_pyogenes_strain_NCTC8198_(—) 58049 chromosome_1_g_5 3639_Streptococcus_pyogenes_strain_NCTC8198_(—) 58050 chromosome_1_g_1 3639_Streptococcus_pyogenes_strain_NCTC8198_(—) 58051 chromosome_1_g_2 3639_Streptococcus_pyogenes_strain_NCTC8198_(—) 58052 chromosome_1_g_3 3639_Streptococcus_pyogenes_strain_NCTC8198_(—) 58053 chromosome_1_g_4 3639_Streptococcus_pyogenes_strain_NCTC8198_(—) 58054 chromosome_1_g_5 3640_Streptococcus_pyogenes_strain_NCTC8198_(—) 58055 chromosome_1_g_1 3640_Streptococcus_pyogenes_strain_NCTC8198_(—) 58056 chromosome_1_g_2 3640_Streptococcus_pyogenes_strain_NCTC8198_(—) 58057 chromosome_1_g_3 3640_Streptococcus_pyogenes_strain_NCTC8198_(—) 58058 chromosome_1_g_4 3640_Streptococcus_pyogenes_strain_NCTC8198_(—) 58059 chromosome_1_g_5 3641_Streptococcus_pyogenes_strain_NCTC8198_(—) 58060 chromosome_1_g_1 3641_Streptococcus_pyogenes_strain_NCTC8198_(—) 58061 chromosome_1_g_2 3641_Streptococcus_pyogenes_strain_NCTC8198_(—) 58062 chromosome_1_g_3 3641_Streptococcus_pyogenes_strain_NCTC8198_(—) 58063 chromosome_1_g_4 3641_Streptococcus_pyogenes_strain_NCTC8198_(—) 58064 chromosome_1_g_5 3642_Streptococcus_pyogenes_strain_NCTC8198_(—) 58065 chromosome_1_g_1 3642_Streptococcus_pyogenes_strain_NCTC8198_(—) 58066 chromosome_1_g_2 3642_Streptococcus_pyogenes_strain_NCTC8198_(—) 58067 chromosome_1_g_3 3642_Streptococcus_pyogenes_strain_NCTC8198_(—) 58068 chromosome_1_g_4 3642_Streptococcus_pyogenes_strain_NCTC8198_(—) 58069 chromosome_1_g_5 3643_Streptococcus_pyogenes_strain_NCTC8198_(—) 58070 chromosome_1_g_1 3643_Streptococcus_pyogenes_strain_NCTC8198_(—) 58071 chromosome_1_g_2 3643_Streptococcus_pyogenes_strain_NCTC8198_(—) 58072 chromosome_1_g_3 3643_Streptococcus_pyogenes_strain_NCTC8198_(—) 58073 chromosome_1_g_4 3643_Streptococcus_pyogenes_strain_NCTC8198_(—) 58074 chromosome_1_g_5 3644_Streptococcus_pyogenes_strain_NCTC8198_(—) 58075 chromosome_1_g_1 3644_Streptococcus_pyogenes_strain_NCTC8198_(—) 58076 chromosome_1_g_2 3644_Streptococcus_pyogenes_strain_NCTC8198_(—) 58077 chromosome_1_g_3 3644_Streptococcus_pyogenes_strain_NCTC8198_(—) 58078 chromosome_1_g_4 3644_Streptococcus_pyogenes_strain_NCTC8198_(—) 58079 chromosome_1_g_5 3645_Streptococcus_pyogenes_strain_NCTC8198_(—) 58080 chromosome_1_g_1 3645_Streptococcus_pyogenes_strain_NCTC8198_(—) 58081 chromosome_1_g_2 3645_Streptococcus_pyogenes_strain_NCTC8198_(—) 58082 chromosome_1_g_3 3645_Streptococcus_pyogenes_strain_NCTC8198_(—) 58083 chromosome_1_g_4 3645_Streptococcus_pyogenes_strain_NCTC8198_(—) 58084 chromosome_1_g_5 3646_Streptococcus_pyogenes_strain_NCTC8198_(—) 58085 chromosome_1_g_1 3646_Streptococcus_pyogenes_strain_NCTC8198_(—) 58086 chromosome_1_g_2 3646_Streptococcus_pyogenes_strain_NCTC8198_(—) 58087 chromosome_1_g_3 3646_Streptococcus_pyogenes_strain_NCTC8198_(—) 58088 chromosome_1_g_4 3646_Streptococcus_pyogenes_strain_NCTC8198_(—) 58089 chromosome_1_g_5 3647_Streptococcus_pyogenes_strain_NCTC8198_(—) 58090 chromosome_1_g_1 3647_Streptococcus_pyogenes_strain_NCTC8198_(—) 58091 chromosome_1_g_2 3647_Streptococcus_pyogenes_strain_NCTC8198_(—) 58092 chromosome_1_g_3 3647_Streptococcus_pyogenes_strain_NCTC8198_(—) 58093 chromosome_1_g_4 3647_Streptococcus_pyogenes_strain_NCTC8198_(—) 58094 chromosome_1_g_5 3648_Streptococcus_pyogenes_strain_NCTC8198_(—) 58095 chromosome_1_g_1 3648_Streptococcus_pyogenes_strain_NCTC8198_(—) 58096 chromosome_1_g_2 3648_Streptococcus_pyogenes_strain_NCTC8198_(—) 58097 chromosome_1_g_3 3648_Streptococcus_pyogenes_strain_NCTC8198_(—) 58098 chromosome_1_g_4 3648_Streptococcus_pyogenes_strain_NCTC8198_(—) 58099 chromosome_1_g_5 3649_Streptococcus_pyogenes_strain_NCTC8198_(—) 58100 chromosome_1_g_1 3649_Streptococcus_pyogenes_strain_NCTC8198_(—) 58101 chromosome_1_g_2 3649_Streptococcus_pyogenes_strain_NCTC8198_(—) 58102 chromosome_1_g_3 3649_Streptococcus_pyogenes_strain_NCTC8198_(—) 58103 chromosome_1_g_4 3649_Streptococcus_pyogenes_strain_NCTC8198_(—) 58104 chromosome_1_g_5 3650_Streptococcus_pyogenes_strain_NCTC8198_(—) 58105 chromosome_1_g_1 3650_Streptococcus_pyogenes_strain_NCTC8198_(—) 58106 chromosome_1_g_2 3650_Streptococcus_pyogenes_strain_NCTC8198_(—) 58107 chromosome_1_g_3 3650_Streptococcus_pyogenes_strain_NCTC8198_(—) 58108 chromosome_1_g_4 3650_Streptococcus_pyogenes_strain_NCTC8198_(—) 58109 chromosome_1_g_5 3651_Streptococcus_pyogenes_strain_NCTC8198_(—) 58110 chromosome_1_g_1 3651_Streptococcus_pyogenes_strain_NCTC8198_(—) 58111 chromosome_1_g_2 3651_Streptococcus_pyogenes_strain_NCTC8198_(—) 58112 chromosome_1_g_3 3651_Streptococcus_pyogenes_strain_NCTC8198_(—) 58113 chromosome_1_g_4 3651_Streptococcus_pyogenes_strain_NCTC8198_(—) 58114 chromosome_1_g_5 3652_Streptococcus_pyogenes_strain_NCTC8198_(—) 58115 chromosome_1_g_1 3652_Streptococcus_pyogenes_strain_NCTC8198_(—) 58116 chromosome_1_g_2 3652_Streptococcus_pyogenes_strain_NCTC8198_(—) 58117 chromosome_1_g_3 3652_Streptococcus_pyogenes_strain_NCTC8198_(—) 58118 chromosome_1_g_4 3652_Streptococcus_pyogenes_strain_NCTC8198_(—) 58119 chromosome_1_g_5 3653_Streptococcus_pyogenes_strain_NCTC8198_(—) 58120 chromosome_1_g_1 3653_Streptococcus_pyogenes_strain_NCTC8198_(—) 58121 chromosome_1_g_2 3653_Streptococcus_pyogenes_strain_NCTC8198_(—) 58122 chromosome_1_g_3 3653_Streptococcus_pyogenes_strain_NCTC8198_(—) 58123 chromosome_1_g_4 3653_Streptococcus_pyogenes_strain_NCTC8198_(—) 58124 chromosome_1_g_5 3654_Streptococcus_pyogenes_strain_NCTC8198_(—) 58125 chromosome_1_g_1 3654_Streptococcus_pyogenes_strain_NCTC8198_(—) 58126 chromosome_1_g_2 3654_Streptococcus_pyogenes_strain_NCTC8198_(—) 58127 chromosome_1_g_3 3654_Streptococcus_pyogenes_strain_NCTC8198_(—) 58128 chromosome_1_g_4 3654_Streptococcus_pyogenes_strain_NCTC8198_(—) 58129 chromosome_1_g_5 3655_Streptococcus_pyogenes_strain_NCTC8198_(—) 58130 chromosome_1_g_1 3655_Streptococcus_pyogenes_strain_NCTC8198_(—) 58131 chromosome_1_g_2 3655_Streptococcus_pyogenes_strain_NCTC8198_(—) 58132 chromosome_1_g_3 3655_Streptococcus_pyogenes_strain_NCTC8198_(—) 58133 chromosome_1_g_4 3655_Streptococcus_pyogenes_strain_NCTC8198_(—) 58134 chromosome_1_g_5 3656_Streptococcus_pyogenes_strain_NCTC8198_(—) 58135 chromosome_1_g_1 3656_Streptococcus_pyogenes_strain_NCTC8198_(—) 58136 chromosome_1_g_2 3656_Streptococcus_pyogenes_strain_NCTC8198_(—) 58137 chromosome_1_g_3 3656_Streptococcus_pyogenes_strain_NCTC8198_(—) 58138 chromosome_1_g_4 3656_Streptococcus_pyogenes_strain_NCTC8198_(—) 58139 chromosome_1_g_5 3657_Streptococcus_pyogenes_strain_NCTC8198_(—) 58140 chromosome_1_g_1 3657_Streptococcus_pyogenes_strain_NCTC8198_(—) 58141 chromosome_1_g_2 3657_Streptococcus_pyogenes_strain_NCTC8198_(—) 58142 chromosome_1_g_3 3657_Streptococcus_pyogenes_strain_NCTC8198_(—) 58143 chromosome_1_g_4 3657_Streptococcus_pyogenes_strain_NCTC8198_(—) 58144 chromosome_1_g_5 3658_Streptococcus_pyogenes_strain_NCTC8198_(—) 58145 chromosome_1_g_1 3658_Streptococcus_pyogenes_strain_NCTC8198_(—) 58146 chromosome_1_g_2 3658_Streptococcus_pyogenes_strain_NCTC8198_(—) 58147 chromosome_1_g_3 3658_Streptococcus_pyogenes_strain_NCTC8198_(—) 58148 chromosome_1_g_4 3658_Streptococcus_pyogenes_strain_NCTC8198_(—) 58149 chromosome_1_g_5 3659_Streptococcus_pyogenes_strain_NCTC8198_(—) 58150 chromosome_1_g_1 3659_Streptococcus_pyogenes_strain_NCTC8198_(—) 58151 chromosome_1_g_2 3659_Streptococcus_pyogenes_strain_NCTC8198_(—) 58152 chromosome_1_g_3 3659_Streptococcus_pyogenes_strain_NCTC8198_(—) 58153 chromosome_1_g_4 3659_Streptococcus_pyogenes_strain_NCTC8198_(—) 58154 chromosome_1_g_5 3660_Streptococcus_pyogenes_strain_NCTC8198_(—) 58155 chromosome_1_g_1 3660_Streptococcus_pyogenes_strain_NCTC8198_(—) 58156 chromosome_1_g_2 3660_Streptococcus_pyogenes_strain_NCTC8198_(—) 58157 chromosome_1_g_3 3660_Streptococcus_pyogenes_strain_NCTC8198_(—) 58158 chromosome_1_g_4 3660_Streptococcus_pyogenes_strain_NCTC8198_(—) 58159 chromosome_1_g_5 3661_Streptococcus_pyogenes_strain_NCTC8198_(—) 58160 chromosome_1_g_1 3661_Streptococcus_pyogenes_strain_NCTC8198_(—) 58161 chromosome_1_g_2 3661_Streptococcus_pyogenes_strain_NCTC8198_(—) 58162 chromosome_1_g_3 3661_Streptococcus_pyogenes_strain_NCTC8198_(—) 58163 chromosome_1_g_4 3661_Streptococcus_pyogenes_strain_NCTC8198_(—) 58164 chromosome_1_g_5 3662_Streptococcus_pyogenes_strain_NCTC8198_(—) 58165 chromosome_1_g_1 3662_Streptococcus_pyogenes_strain_NCTC8198_(—) 58166 chromosome_1_g_2 3662_Streptococcus_pyogenes_strain_NCTC8198_(—) 58167 chromosome_1_g_3 3662_Streptococcus_pyogenes_strain_NCTC8198_(—) 58168 chromosome_1_g_4 3662_Streptococcus_pyogenes_strain_NCTC8198_(—) 58169 chromosome_1_g_5 3663_Streptococcus_pyogenes_strain_NCTC8198_(—) 58170 chromosome_1_g_1 3663_Streptococcus_pyogenes_strain_NCTC8198_(—) 58171 chromosome_1_g_2 3663_Streptococcus_pyogenes_strain_NCTC8198_(—) 58172 chromosome_1_g_3 3663_Streptococcus_pyogenes_strain_NCTC8198_(—) 58173 chromosome_1_g_4 3663_Streptococcus_pyogenes_strain_NCTC8198_(—) 58174 chromosome_1_g_5 3664_Streptococcus_pyogenes_strain_NCTC8198_(—) 58175 chromosome_1_g_1 3664_Streptococcus_pyogenes_strain_NCTC8198_(—) 58176 chromosome_1_g_2 3664_Streptococcus_pyogenes_strain_NCTC8198_(—) 58177 chromosome_1_g_3 3664_Streptococcus_pyogenes_strain_NCTC8198_(—) 58178 chromosome_1_g_4 3664_Streptococcus_pyogenes_strain_NCTC8198_(—) 58179 chromosome_1_g_5 3665_Streptococcus_pyogenes_strain_NCTC8198_(—) 58180 chromosome_1_g_1 3665_Streptococcus_pyogenes_strain_NCTC8198_(—) 58181 chromosome_1_g_2 3665_Streptococcus_pyogenes_strain_NCTC8198_(—) 58182 chromosome_1_g_3 3665_Streptococcus_pyogenes_strain_NCTC8198_(—) 58183 chromosome_1_g_4 3665_Streptococcus_pyogenes_strain_NCTC8198_(—) 58184 chromosome_1_g_5 3666_Streptococcus_pyogenes_strain_NCTC8198_(—) 58185 chromosome_1_g_1 3666_Streptococcus_pyogenes_strain_NCTC8198_(—) 58186 chromosome_1_g_2 3666_Streptococcus_pyogenes_strain_NCTC8198_(—) 58187 chromosome_1_g_3 3666_Streptococcus_pyogenes_strain_NCTC8198_(—) 58188 chromosome_1_g_4 3666_Streptococcus_pyogenes_strain_NCTC8198_(—) 58189 chromosome_1_g_5 3667_Streptococcus_pyogenes_strain_NCTC8198_(—) 58190 chromosome_1_g_1 3667_Streptococcus_pyogenes_strain_NCTC8198_(—) 58191 chromosome_1_g_2 3667_Streptococcus_pyogenes_strain_NCTC8198_(—) 58192 chromosome_1_g_3 3667_Streptococcus_pyogenes_strain_NCTC8198_(—) 58193 chromosome_1_g_4 3667_Streptococcus_pyogenes_strain_NCTC8198_(—) 58194 chromosome_1_g_5 3668_Streptococcus_pyogenes_strain_NCTC8198_(—) 58195 chromosome_1_g_1 3668_Streptococcus_pyogenes_strain_NCTC8198_(—) 58196 chromosome_1_g_2 3668_Streptococcus_pyogenes_strain_NCTC8198_(—) 58197 chromosome_1_g_3 3668_Streptococcus_pyogenes_strain_NCTC8198_(—) 58198 chromosome_1_g_4 3668_Streptococcus_pyogenes_strain_NCTC8198_(—) 58199 chromosome_1_g_5 3669_Streptococcus_pyogenes_strain_NCTC8198_(—) 58200 chromosome_1_g_1 3669_Streptococcus_pyogenes_strain_NCTC8198_(—) 58201 chromosome_1_g_2 3669_Streptococcus_pyogenes_strain_NCTC8198_(—) 58202 chromosome_1_g_3 3669_Streptococcus_pyogenes_strain_NCTC8198_(—) 58203 chromosome_1_g_4 3669_Streptococcus_pyogenes_strain_NCTC8198_(—) 58204 chromosome_1_g_5 3670_Streptococcus_pyogenes_strain_NCTC8198_(—) 58205 chromosome_1_g_1 3670_Streptococcus_pyogenes_strain_NCTC8198_(—) 58206 chromosome_1_g_2 3670_Streptococcus_pyogenes_strain_NCTC8198_(—) 58207 chromosome_1_g_3 3670_Streptococcus_pyogenes_strain_NCTC8198_(—) 58208 chromosome_1_g_4 3670_Streptococcus_pyogenes_strain_NCTC8198_(—) 58209 chromosome_1_g_5 3671_Streptococcus_pyogenes_strain_NCTC8198_(—) 58210 chromosome_1_g_1 3671_Streptococcus_pyogenes_strain_NCTC8198_(—) 58211 chromosome_1_g_2 3671_Streptococcus_pyogenes_strain_NCTC8198_(—) 58212 chromosome_1_g_3 3671_Streptococcus_pyogenes_strain_NCTC8198_(—) 58213 chromosome_1_g_4 3671_Streptococcus_pyogenes_strain_NCTC8198_(—) 58214 chromosome_1_g_5 3672_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58215 3672_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58216 3672_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58217 3672_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58218 3672_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58219 3673_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58220 3673_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58221 3673_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58222 3673_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58223 3673_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58224 3674_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58225 3674_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58226 3674_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58227 3674_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58228 3674_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58229 3675_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58230 3675_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58231 3675_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58232 3675_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58233 3675_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58234 3676_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58235 3676_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58236 3676_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58237 3676_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58238 3676_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58239 3677_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58240 3677_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58241 3677_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58242 3677_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58243 3677_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58244 3678_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58245 3678_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58246 3678_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58247 3678_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58248 3678_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58249 3679_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58250 3679_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58251 3679_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58252 3679_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58253 3679_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58254 3680_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58255 3680_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58256 3680_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58257 3680_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58258 3680_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58259 3681_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58260 3681_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58261 3681_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58262 3681_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58263 3682_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58264 3682_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58265 3682_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58266 3682_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58267 3682_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58268 3683_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58269 3683_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58270 3683_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58271 3683_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58272 3683_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58273 3684_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58274 3684_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58275 3684_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58276 3684_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58277 3685_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58278 3685_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58279 3685_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58280 3685_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58281 3685_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58282 3686_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58283 3686_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58284 3686_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58285 3686_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58286 3686_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58287 3687_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58288 3687_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58289 3687_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58290 3687_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58291 3687_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58292 3688_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58293 3688_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58294 3688_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58295 3688_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58296 3688_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58297 3689_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58298 3689_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58299 3689_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58300 3689_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58301 3689_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58302 3690_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58303 3690_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58304 3690_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58305 3690_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58306 3690_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58307 3691_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58308 3691_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58309 3691_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58310 3691_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58311 3691_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58312 3692_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58313 3692_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58314 3692_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58315 3693_Hepatitis_E_virus_rat/R63/DEU/2009_g_1 58316 3693_Hepatitis_E_virus_rat/R63/DEU/2009_g_2 58317 3693_Hepatitis_E_virus_rat/R63/DEU/2009_g_3 58318 3693_Hepatitis_E_virus_rat/R63/DEU/2009_g_4 58319 3693_Hepatitis_E_virus_rat/R63/DEU/2009_g_5 58320 3694_Human_Coronavirus_NL63_g_1 58321 3694_Human_Coronavirus_NL63_g_2 58322 3694_Human_Coronavirus_NL63_g_3 58323 3694_Human_Coronavirus_NL63_g_4 58324 3694_Human_Coronavirus_NL63_g_5 58325 3695_Human_Coronavirus_NL63_g_1 58326 3695_Human_Coronavirus_NL63_g_2 58327 3695_Human_Coronavirus_NL63_g_3 58328 3695_Human_Coronavirus_NL63_g_4 58329 3695_Human_Coronavirus_NL63_g_5 58330 3696_Human_Coronavirus_NL63_g_1 58331 3696_Human_Coronavirus_NL63_g_2 58332 3696_Human_Coronavirus_NL63_g_3 58333 3696_Human_Coronavirus_NL63_g_4 58334 3696_Human_Coronavirus_NL63_g_5 58335 3697_Human_Coronavirus_NL63_g_1 58336 3697_Human_Coronavirus_NL63_g_2 58337 3697_Human_Coronavirus_NL63_g_3 58338 3697_Human_Coronavirus_NL63_g_4 58339 3697_Human_Coronavirus_NL63_g_5 58340 3698_Human_Coronavirus_NL63_g_1 58341 3698_Human_Coronavirus_NL63_g_2 58342 3698_Human_Coronavirus_NL63_g_3 58343 3698_Human_Coronavirus_NL63_g_4 58344 3698_Human_Coronavirus_NL63_g_5 58345 3699_Human_Coronavirus_NL63_g_1 58346 3699_Human_Coronavirus_NL63_g_2 58347 3699_Human_Coronavirus_NL63_g_3 58348 3699_Human_Coronavirus_NL63_g_4 58349 3699_Human_Coronavirus_NL63_g_5 58350 3700_Human_Coronavirus_NL63_g_1 58351 3700_Human_Coronavirus_NL63_g_2 58352 3700_Human_Coronavirus_NL63_g_3 58353 3700_Human_Coronavirus_NL63_g_4 58354 3700_Human_Coronavirus_NL63_g_5 58355 3701_Human_Coronavirus_NL63_g_1 58356 3701_Human_Coronavirus_NL63_g_2 58357 3701_Human_Coronavirus_NL63_g_3 58358 3701_Human_Coronavirus_NL63_g_4 58359 3701_Human_Coronavirus_NL63_g_5 58360 3702_Human_Coronavirus_NL63_g_1 58361 3702_Human_Coronavirus_NL63_g_2 58362 3702_Human_Coronavirus_NL63_g_3 58363 3702_Human_Coronavirus_NL63_g_4 58364 3702_Human_Coronavirus_NL63_g_5 58365 3703_Human_Coronavirus_NL63_g_1 58366 3703_Human_Coronavirus_NL63_g_2 58367 3703_Human_Coronavirus_NL63_g_3 58368 3703_Human_Coronavirus_NL63_g_4 58369 3703_Human_Coronavirus_NL63_g_5 58370 3704_Human_Coronavirus_NL63_g_1 58371 3704_Human_Coronavirus_NL63_g_2 58372 3704_Human_Coronavirus_NL63_g_3 58373 3704_Human_Coronavirus_NL63_g_4 58374 3704_Human_Coronavirus_NL63_g_5 58375 3705_Human_Coronavirus_NL63_g_1 58376 3705_Human_Coronavirus_NL63_g_2 58377 3705_Human_Coronavirus_NL63_g_3 58378 3705_Human_Coronavirus_NL63_g_4 58379 3705_Human_Coronavirus_NL63_g_5 58380 3706_Human_Coronavirus_NL63_g_1 58381 3706_Human_Coronavirus_NL63_g_2 58382 3706_Human_Coronavirus_NL63_g_3 58383 3706_Human_Coronavirus_NL63_g_4 58384 3706_Human_Coronavirus_NL63_g_5 58385 3707_Human_Coronavirus_NL63_g_1 58386 3707_Human_Coronavirus_NL63_g_2 58387 3707_Human_Coronavirus_NL63_g_3 58388 3707_Human_Coronavirus_NL63_g_4 58389 3707_Human_Coronavirus_NL63_g_5 58390 3708_Human_Coronavirus_NL63_g_1 58391 3708_Human_Coronavirus_NL63_g_2 58392 3708_Human_Coronavirus_NL63_g_3 58393 3708_Human_Coronavirus_NL63_g_4 58394 3708_Human_Coronavirus_NL63_g_5 58395 3709_Human_Coronavirus_NL63_g_1 58396 3709_Human_Coronavirus_NL63_g_2 58397 3709_Human_Coronavirus_NL63_g_3 58398 3709_Human_Coronavirus_NL63_g_4 58399 3709_Human_Coronavirus_NL63_g_5 58400 3710_Human_Coronavirus_NL63_g_1 58401 3710_Human_Coronavirus_NL63_g_2 58402 3710_Human_Coronavirus_NL63_g_3 58403 3710_Human_Coronavirus_NL63_g_4 58404 3710_Human_Coronavirus_NL63_g_5 58405 3711_Human_Coronavirus_NL63_g_1 58406 3711_Human_Coronavirus_NL63_g_2 58407 3711_Human_Coronavirus_NL63_g_3 58408 3711_Human_Coronavirus_NL63_g_4 58409 3711_Human_Coronavirus_NL63_g_5 58410 3712_Human_Coronavirus_NL63_g_1 58411 3712_Human_Coronavirus_NL63_g_2 58412 3712_Human_Coronavirus_NL63_g_3 58413 3712_Human_Coronavirus_NL63_g_4 58414 3712_Human_Coronavirus_NL63_g_5 58415 3713_Human_Coronavirus_NL63_g_1 58416 3713_Human_Coronavirus_NL63_g_2 58417 3713_Human_Coronavirus_NL63_g_3 58418 3713_Human_Coronavirus_NL63_g_4 58419 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3782_Influenza_B_virus_(B/Lee/1940)_segment_8_g_4 58761 3782_Influenza_B_virus_(B/Lee/1940)_segment_8_g_5 58762 3783_Hepatitis_A_virus_g_1 58763 3783_Hepatitis_A_virus_g_2 58764 3783_Hepatitis_A_virus_g_3 58765 3783_Hepatitis_A_virus_g_4 58766 3783_Hepatitis_A_virus_g_5 58767 3784_Hepatitis_A_virus_g_1 58768 3784_Hepatitis_A_virus_g_2 58769 3784_Hepatitis_A_virus_g_3 58770 3784_Hepatitis_A_virus_g_4 58771 3784_Hepatitis_A_virus_g_5 58772 3785_Hepatitis_A_virus_g_1 58773 3785_Hepatitis_A_virus_g_2 58774 3785_Hepatitis_A_virus_g_3 58775 3785_Hepatitis_A_virus_g_4 58776 3785_Hepatitis_A_virus_g_5 58777 3786_Hepatitis_A_virus_g_1 58778 3786_Hepatitis_A_virus_g_2 58779 3786_Hepatitis_A_virus_g_3 58780 3786_Hepatitis_A_virus_g_4 58781 3786_Hepatitis_A_virus_g_5 58782 3787_Hepatitis_A_virus_g_1 58783 3787_Hepatitis_A_virus_g_2 58784 3787_Hepatitis_A_virus_g_3 58785 3787_Hepatitis_A_virus_g_4 58786 3787_Hepatitis_A_virus_g_5 58787 3788_Hepatitis_A_virus_g_1 58788 3788_Hepatitis_A_virus_g_2 58789 3788_Hepatitis_A_virus_g_3 58790 3788_Hepatitis_A_virus_g_4 58791 3788_Hepatitis_A_virus_g_5 58792 3789_Hepatitis_A_virus_g_1 58793 3789_Hepatitis_A_virus_g_2 58794 3789_Hepatitis_A_virus_g_3 58795 3789_Hepatitis_A_virus_g_4 58796 3789_Hepatitis_A_virus_g_5 58797 3790_Hepatitis_A_virus_g_1 58798 3790_Hepatitis_A_virus_g_2 58799 3790_Hepatitis_A_virus_g_3 58800 3790_Hepatitis_A_virus_g_4 58801 3790_Hepatitis_A_virus_g_5 58802 3791_Hepatitis_A_virus_g_1 58803 3791_Hepatitis_A_virus_g_2 58804 3791_Hepatitis_A_virus_g_3 58805 3791_Hepatitis_A_virus_g_4 58806 3791_Hepatitis_A_virus_g_5 58807 3792_Hepatitis_A_virus_g_1 58808 3792_Hepatitis_A_virus_g_2 58809 3792_Hepatitis_A_virus_g_3 58810 3792_Hepatitis_A_virus_g_4 58811 3792_Hepatitis_A_virus_g_5 58812 3793_Hepatitis_A_virus_g_1 58813 3793_Hepatitis_A_virus_g_2 58814 3793_Hepatitis_A_virus_g_3 58815 3793_Hepatitis_A_virus_g_4 58816 3793_Hepatitis_A_virus_g_5 58817 3794_Hepatitis_A_virus_g_1 58818 3794_Hepatitis_A_virus_g_2 58819 3794_Hepatitis_A_virus_g_3 58820 3794_Hepatitis_A_virus_g_4 58821 3794_Hepatitis_A_virus_g_5 58822 3795_Hepatitis_A_virus_g_1 58823 3795_Hepatitis_A_virus_g_2 58824 3795_Hepatitis_A_virus_g_3 58825 3795_Hepatitis_A_virus_g_4 58826 3795_Hepatitis_A_virus_g_5 58827 3796_Hepatitis_A_virus_g_1 58828 3796_Hepatitis_A_virus_g_2 58829 3796_Hepatitis_A_virus_g_3 58830 3796_Hepatitis_A_virus_g_4 58831 3796_Hepatitis_A_virus_g_5 58832 3797_Hepatitis_A_virus_g_1 58833 3797_Hepatitis_A_virus_g_2 58834 3797_Hepatitis_A_virus_g_3 58835 3797_Hepatitis_A_virus_g_4 58836 3797_Hepatitis_A_virus_g_5 58837 3798_Hepatitis_A_virus_g_1 58838 3798_Hepatitis_A_virus_g_2 58839 3798_Hepatitis_A_virus_g_3 58840 3798_Hepatitis_A_virus_g_4 58841 3798_Hepatitis_A_virus_g_5 58842 3799_Hepatitis_A_virus_g_1 58843 3799_Hepatitis_A_virus_g_2 58844 3799_Hepatitis_A_virus_g_3 58845 3799_Hepatitis_A_virus_g_4 58846 3799_Hepatitis_A_virus_g_5 58847 3800_Hepatitis_A_virus_g_1 58848 3800_Hepatitis_A_virus_g_2 58849 3800_Hepatitis_A_virus_g_3 58850 3800_Hepatitis_A_virus_g_4 58851 3800_Hepatitis_A_virus_g_5 58852 3801_Hepatitis_A_virus_g_1 58853 3801_Hepatitis_A_virus_g_2 58854 3801_Hepatitis_A_virus_g_3 58855 3801_Hepatitis_A_virus_g_4 58856 3801_Hepatitis_A_virus_g_5 58857 3802_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58858 segment_4_g_1 3802_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58859 segment_4_g_2 3802_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58860 segment_4_g_3 3802_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58861 segment_4_g_4 3802_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58862 segment_4_g_5 3803_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58863 segment_4_g_1 3803_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58864 segment_4_g_2 3803_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58865 segment_4_g_3 3803_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58866 segment_4_g_4 3803_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58867 segment_4_g_5 3804_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58868 segment_4_g_1 3804_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58869 segment_4_g_2 3804_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58870 segment_4_g_3 3804_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58871 segment_4_g_4 3804_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58872 segment_4_g_5 3805_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58873 segment_4_g_1 3805_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58874 segment_4_g_2 3805_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58875 segment_4_g_3 3805_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58876 segment_4_g_4 3805_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58877 segment_4_g_5 3806_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58878 segment_4_g_1 3806_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58879 segment_4_g_2 3806_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58880 segment_4_g_3 3806_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58881 segment_4_g_4 3806_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58882 segment_4_g_5 3807_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58883 segment_4_g_1 3807_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58884 segment_4_g_2 3807_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58885 segment_4_g_3 3807_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58886 segment_4_g_4 3807_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58887 segment_4_g_5 3808_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58888 segment_4_g_1 3808_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58889 segment_4_g_2 3808_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58890 segment_4_g_3 3808_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58891 segment_4_g_4 3808_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 58892 segment_4_g_5 3809_Human_papillomavirus_type_96_g_1 58893 3809_Human_papillomavirus_type_96_g_2 58894 3809_Human_papillomavirus_type_96_g_3 58895 3809_Human_papillomavirus_type_96_g_4 58896 3809_Human_papillomavirus_type_96_g_5 58897 3810_Human_papillomavirus_type_96_g_1 58898 3810_Human_papillomavirus_type_96_g_2 58899 3810_Human_papillomavirus_type_96_g_3 58900 3810_Human_papillomavirus_type_96_g_4 58901 3810_Human_papillomavirus_type_96_g_5 58902 3811_Human_papillomavirus_type_96_g_1 58903 3811_Human_papillomavirus_type_96_g_2 58904 3811_Human_papillomavirus_type_96_g_3 58905 3811_Human_papillomavirus_type_96_g_4 58906 3811_Human_papillomavirus_type_96_g_5 58907 3812_Human_papillomavirus_type_96_g_1 58908 3812_Human_papillomavirus_type_96_g_2 58909 3812_Human_papillomavirus_type_96_g_3 58910 3812_Human_papillomavirus_type_96_g_4 58911 3812_Human_papillomavirus_type_96_g_5 58912 3813_Human_papillomavirus_type_96_g_1 58913 3813_Human_papillomavirus_type_96_g_2 58914 3813_Human_papillomavirus_type_96_g_3 58915 3813_Human_papillomavirus_type_96_g_4 58916 3813_Human_papillomavirus_type_96_g_5 58917 3814_Human_papillomavirus_type_96_g_1 58918 3814_Human_papillomavirus_type_96_g_2 58919 3814_Human_papillomavirus_type_96_g_3 58920 3814_Human_papillomavirus_type_96_g_4 58921 3814_Human_papillomavirus_type_96_g_5 58922 3815_Human_papillomavirus_type_96_g_1 58923 3815_Human_papillomavirus_type_96_g_2 58924 3815_Human_papillomavirus_type_96_g_3 58925 3815_Human_papillomavirus_type_96_g_4 58926 3815_Human_papillomavirus_type_96_g_5 58927 3816_Human_papillomavirus_type_96_g_1 58928 3816_Human_papillomavirus_type_96_g_2 58929 3816_Human_papillomavirus_type_96_g_3 58930 3816_Human_papillomavirus_type_96_g_4 58931 3816_Human_papillomavirus_type_96_g_5 58932 3817_Human_papillomavirus_type_96_g_1 58933 3817_Human_papillomavirus_type_96_g_2 58934 3817_Human_papillomavirus_type_96_g_3 58935 3817_Human_papillomavirus_type_96_g_4 58936 3817_Human_papillomavirus_type_96_g_5 58937 3818_Human_papillomavirus_type_96_g_1 58938 3818_Human_papillomavirus_type_96_g_2 58939 3818_Human_papillomavirus_type_96_g_3 58940 3818_Human_papillomavirus_type_96_g_4 58941 3818_Human_papillomavirus_type_96_g_5 58942 3819_Human_papillomavirus_type_96_g_1 58943 3819_Human_papillomavirus_type_96_g_2 58944 3819_Human_papillomavirus_type_96_g_3 58945 3819_Human_papillomavirus_type_96_g_4 58946 3819_Human_papillomavirus_type_96_g_5 58947 3820_Human_papillomavirus_type_96_g_1 58948 3820_Human_papillomavirus_type_96_g_2 58949 3820_Human_papillomavirus_type_96_g_3 58950 3820_Human_papillomavirus_type_96_g_4 58951 3820_Human_papillomavirus_type_96_g_5 58952 3821_Human_papillomavirus_type_96_g_1 58953 3821_Human_papillomavirus_type_96_g_2 58954 3821_Human_papillomavirus_type_96_g_3 58955 3821_Human_papillomavirus_type_96_g_4 58956 3821_Human_papillomavirus_type_96_g_5 58957 3822_Human_papillomavirus_type_96_g_1 58958 3822_Human_papillomavirus_type_96_g_2 58959 3822_Human_papillomavirus_type_96_g_3 58960 3822_Human_papillomavirus_type_96_g_4 58961 3822_Human_papillomavirus_type_96_g_5 58962 3823_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58963 segment_6_g_1 3823_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58964 segment_6_g_2 3823_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58965 segment_6_g_3 3823_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58966 segment_6_g_4 3823_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58967 segment_6_g_5 3824_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58968 segment_6_g_1 3824_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58969 segment_6_g_2 3824_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58970 segment_6_g_3 3824_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58971 segment_6_g_4 3824_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58972 segment_6_g_5 3825_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58973 segment_6_g_1 3825_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58974 segment_6_g_2 3825_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58975 segment_6_g_3 3825_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58976 segment_6_g_4 3825_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58977 segment_6_g_5 3826_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58978 segment_6_g_1 3826_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58979 segment_6_g_2 3826_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58980 segment_6_g_3 3826_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58981 segment_6_g_4 3826_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58982 segment_6_g_5 3827_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58983 segment_6_g_1 3827_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58984 segment_6_g_2 3827_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58985 segment_6_g_3 3827_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58986 segment_6_g_4 3827_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 58987 segment_6_g_5 3828_Human_betaherpesvirus_6A_g_1 58988 3828_Human_betaherpesvirus_6A_g_2 58989 3829_Human_betaherpesvirus_6A_g_1 58990 3829_Human_betaherpesvirus_6A_g_2 58991 3829_Human_betaherpesvirus_6A_g_3 58992 3830_Human_betaherpesvirus_6A_g_1 58993 3830_Human_betaherpesvirus_6A_g_2 58994 3830_Human_betaherpesvirus_6A_g_3 58995 3830_Human_betaherpesvirus_6A_g_4 58996 3830_Human_betaherpesvirus_6A_g_5 58997 3831_Human_betaherpesvirus_6A_g_1 58998 3831_Human_betaherpesvirus_6A_g_2 58999 3831_Human_betaherpesvirus_6A_g_3 59000 3831_Human_betaherpesvirus_6A_g_4 59001 3831_Human_betaherpesvirus_6A_g_5 59002 3832_Human_betaherpesvirus_6A_g_1 59003 3832_Human_betaherpesvirus_6A_g_2 59004 3832_Human_betaherpesvirus_6A_g_3 59005 3832_Human_betaherpesvirus_6A_g_4 59006 3832_Human_betaherpesvirus_6A_g_5 59007 3833_Human_betaherpesvirus_6A_g_1 59008 3833_Human_betaherpesvirus_6A_g_2 59009 3834_Human_betaherpesvirus_6A_g_1 59010 3834_Human_betaherpesvirus_6A_g_2 59011 3834_Human_betaherpesvirus_6A_g_3 59012 3834_Human_betaherpesvirus_6A_g_4 59013 3834_Human_betaherpesvirus_6A_g_5 59014 3835_Human_betaherpesvirus_6A_g_1 59015 3835_Human_betaherpesvirus_6A_g_2 59016 3835_Human_betaherpesvirus_6A_g_3 59017 3835_Human_betaherpesvirus_6A_g_4 59018 3835_Human_betaherpesvirus_6A_g_5 59019 3836_Human_betaherpesvirus_6A_g_1 59020 3836_Human_betaherpesvirus_6A_g_2 59021 3836_Human_betaherpesvirus_6A_g_3 59022 3836_Human_betaherpesvirus_6A_g_4 59023 3836_Human_betaherpesvirus_6A_g_5 59024 3837_Human_betaherpesvirus_6A_g_1 59025 3837_Human_betaherpesvirus_6A_g_2 59026 3837_Human_betaherpesvirus_6A_g_3 59027 3837_Human_betaherpesvirus_6A_g_4 59028 3837_Human_betaherpesvirus_6A_g_5 59029 3838_Human_betaherpesvirus_6A_g_1 59030 3838_Human_betaherpesvirus_6A_g_2 59031 3838_Human_betaherpesvirus_6A_g_3 59032 3838_Human_betaherpesvirus_6A_g_4 59033 3838_Human_betaherpesvirus_6A_g_5 59034 3839_Human_betaherpesvirus_6A_g_1 59035 3839_Human_betaherpesvirus_6A_g_2 59036 3839_Human_betaherpesvirus_6A_g_3 59037 3839_Human_betaherpesvirus_6A_g_4 59038 3839_Human_betaherpesvirus_6A_g_5 59039 3840_Human_betaherpesvirus_6A_g_1 59040 3840_Human_betaherpesvirus_6A_g_2 59041 3840_Human_betaherpesvirus_6A_g_3 59042 3840_Human_betaherpesvirus_6A_g_4 59043 3840_Human_betaherpesvirus_6A_g_5 59044 3841_Human_betaherpesvirus_6A_g_1 59045 3841_Human_betaherpesvirus_6A_g_2 59046 3841_Human_betaherpesvirus_6A_g_3 59047 3841_Human_betaherpesvirus_6A_g_4 59048 3841_Human_betaherpesvirus_6A_g_5 59049 3842_Human_betaherpesvirus_6A_g_1 59050 3842_Human_betaherpesvirus_6A_g_2 59051 3842_Human_betaherpesvirus_6A_g_3 59052 3842_Human_betaherpesvirus_6A_g_4 59053 3842_Human_betaherpesvirus_6A_g_5 59054 3843_Human_betaherpesvirus_6A_g_1 59055 3843_Human_betaherpesvirus_6A_g_2 59056 3843_Human_betaherpesvirus_6A_g_3 59057 3843_Human_betaherpesvirus_6A_g_4 59058 3843_Human_betaherpesvirus_6A_g_5 59059 3844_Human_betaherpesvirus_6A_g_1 59060 3844_Human_betaherpesvirus_6A_g_2 59061 3844_Human_betaherpesvirus_6A_g_3 59062 3844_Human_betaherpesvirus_6A_g_4 59063 3844_Human_betaherpesvirus_6A_g_5 59064 3845_Human_betaherpesvirus_6A_g_1 59065 3845_Human_betaherpesvirus_6A_g_2 59066 3845_Human_betaherpesvirus_6A_g_3 59067 3845_Human_betaherpesvirus_6A_g_4 59068 3845_Human_betaherpesvirus_6A_g_5 59069 3846_Human_betaherpesvirus_6A_g_1 59070 3846_Human_betaherpesvirus_6A_g_2 59071 3846_Human_betaherpesvirus_6A_g_3 59072 3846_Human_betaherpesvirus_6A_g_4 59073 3846_Human_betaherpesvirus_6A_g_5 59074 3847_Human_betaherpesvirus_6A_g_1 59075 3847_Human_betaherpesvirus_6A_g_2 59076 3847_Human_betaherpesvirus_6A_g_3 59077 3847_Human_betaherpesvirus_6A_g_4 59078 3847_Human_betaherpesvirus_6A_g_5 59079 3848_Human_betaherpesvirus_6A_g_1 59080 3848_Human_betaherpesvirus_6A_g_2 59081 3848_Human_betaherpesvirus_6A_g_3 59082 3848_Human_betaherpesvirus_6A_g_4 59083 3848_Human_betaherpesvirus_6A_g_5 59084 3849_Human_betaherpesvirus_6A_g_1 59085 3849_Human_betaherpesvirus_6A_g_2 59086 3849_Human_betaherpesvirus_6A_g_3 59087 3849_Human_betaherpesvirus_6A_g_4 59088 3849_Human_betaherpesvirus_6A_g_5 59089 3850_Human_betaherpesvirus_6A_g_1 59090 3850_Human_betaherpesvirus_6A_g_2 59091 3850_Human_betaherpesvirus_6A_g_3 59092 3850_Human_betaherpesvirus_6A_g_4 59093 3850_Human_betaherpesvirus_6A_g_5 59094 3851_Human_betaherpesvirus_6A_g_1 59095 3851_Human_betaherpesvirus_6A_g_2 59096 3851_Human_betaherpesvirus_6A_g_3 59097 3851_Human_betaherpesvirus_6A_g_4 59098 3851_Human_betaherpesvirus_6A_g_5 59099 3852_Human_betaherpesvirus_6A_g_1 59100 3852_Human_betaherpesvirus_6A_g_2 59101 3852_Human_betaherpesvirus_6A_g_3 59102 3852_Human_betaherpesvirus_6A_g_4 59103 3852_Human_betaherpesvirus_6A_g_5 59104 3853_Human_betaherpesvirus_6A_g_1 59105 3853_Human_betaherpesvirus_6A_g_2 59106 3853_Human_betaherpesvirus_6A_g_3 59107 3853_Human_betaherpesvirus_6A_g_4 59108 3853_Human_betaherpesvirus_6A_g_5 59109 3854_Human_betaherpesvirus_6A_g_1 59110 3854_Human_betaherpesvirus_6A_g_2 59111 3854_Human_betaherpesvirus_6A_g_3 59112 3854_Human_betaherpesvirus_6A_g_4 59113 3854_Human_betaherpesvirus_6A_g_5 59114 3855_Human_betaherpesvirus_6A_g_1 59115 3855_Human_betaherpesvirus_6A_g_2 59116 3855_Human_betaherpesvirus_6A_g_3 59117 3856_Human_betaherpesvirus_6A_g_1 59118 3856_Human_betaherpesvirus_6A_g_2 59119 3856_Human_betaherpesvirus_6A_g_3 59120 3857_Human_betaherpesvirus_6A_g_1 59121 3857_Human_betaherpesvirus_6A_g_2 59122 3857_Human_betaherpesvirus_6A_g_3 59123 3857_Human_betaherpesvirus_6A_g_4 59124 3857_Human_betaherpesvirus_6A_g_5 59125 3858_Human_betaherpesvirus_6A_g_1 59126 3858_Human_betaherpesvirus_6A_g_2 59127 3858_Human_betaherpesvirus_6A_g_3 59128 3858_Human_betaherpesvirus_6A_g_4 59129 3859_Human_betaherpesvirus_6A_g_1 59130 3859_Human_betaherpesvirus_6A_g_2 59131 3859_Human_betaherpesvirus_6A_g_3 59132 3859_Human_betaherpesvirus_6A_g_4 59133 3859_Human_betaherpesvirus_6A_g_5 59134 3860_Influenza_B_virus_(B/Lee/1940)_segment_3_g_1 59135 3860_Influenza_B_virus_(B/Lee/1940)_segment_3_g_2 59136 3860_Influenza_B_virus_(B/Lee/1940)_segment_3_g_3 59137 3860_Influenza_B_virus_(B/Lee/1940)_segment_3_g_4 59138 3860_Influenza_B_virus_(B/Lee/1940)_segment_3_g_5 59139 3861_Influenza_B_virus_(B/Lee/1940)_segment_3_g_1 59140 3861_Influenza_B_virus_(B/Lee/1940)_segment_3_g_2 59141 3861_Influenza_B_virus_(B/Lee/1940)_segment_3_g_3 59142 3861_Influenza_B_virus_(B/Lee/1940)_segment_3_g_4 59143 3861_Influenza_B_virus_(B/Lee/1940)_segment_3_g_5 59144 3862_Influenza_B_virus_(B/Lee/1940)_segment_3_g_1 59145 3862_Influenza_B_virus_(B/Lee/1940)_segment_3_g_2 59146 3862_Influenza_B_virus_(B/Lee/1940)_segment_3_g_3 59147 3862_Influenza_B_virus_(B/Lee/1940)_segment_3_g_4 59148 3862_Influenza_B_virus_(B/Lee/1940)_segment_3_g_5 59149 3863_Influenza_B_virus_(B/Lee/1940)_segment_3_g_1 59150 3863_Influenza_B_virus_(B/Lee/1940)_segment_3_g_2 59151 3863_Influenza_B_virus_(B/Lee/1940)_segment_3_g_3 59152 3863_Influenza_B_virus_(B/Lee/1940)_segment_3_g_4 59153 3863_Influenza_B_virus_(B/Lee/1940)_segment_3_g_5 59154 3864_Influenza_B_virus_(B/Lee/1940)_segment_3_g_1 59155 3864_Influenza_B_virus_(B/Lee/1940)_segment_3_g_2 59156 3864_Influenza_B_virus_(B/Lee/1940)_segment_3_g_3 59157 3864_Influenza_B_virus_(B/Lee/1940)_segment_3_g_4 59158 3864_Influenza_B_virus_(B/Lee/1940)_segment_3_g_5 59159 3865_Influenza_B_virus_(B/Lee/1940)_segment_3_g_1 59160 3865_Influenza_B_virus_(B/Lee/1940)_segment_3_g_2 59161 3865_Influenza_B_virus_(B/Lee/1940)_segment_3_g_3 59162 3865_Influenza_B_virus_(B/Lee/1940)_segment_3_g_4 59163 3865_Influenza_B_virus_(B/Lee/1940)_segment_3_g_5 59164 3866_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59165 segment_4_hemagglutinin_(HA)_gene_g_1 3866_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59166 segment_4_hemagglutinin_(HA)_gene_g_2 3866_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59167 segment_4_hemagglutinin_(HA)_gene_g_3 3866_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59168 segment_4_hemagglutinin_(HA)_gene_g_4 3866_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59169 segment_4_hemagglutinin_(HA)_gene_g_5 3867_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59170 segment_4_hemagglutinin_(HA)_gene_g_1 3867_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59171 segment_4_hemagglutinin_(HA)_gene_g_2 3867_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59172 segment_4_hemagglutinin_(HA)_gene_g_3 3867_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59173 segment_4_hemagglutinin_(HA)_gene_g_4 3867_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59174 segment_4_hemagglutinin_(HA)_gene_g_5 3868_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59175 segment_4_hemagglutinin_(HA)_gene_g_1 3868_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59176 segment_4_hemagglutinin_(HA)_gene_g_2 3868_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59177 segment_4_hemagglutinin_(HA)_gene_g_3 3868_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59178 segment_4_hemagglutinin_(HA)_gene_g_4 3868_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59179 segment_4_hemagglutinin_(HA)_gene_g_5 3869_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59180 segment_4_hemagglutinin_(HA)_gene_g_1 3869_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59181 segment_4_hemagglutinin_(HA)_gene_g_2 3869_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59182 segment_4_hemagglutinin_(HA)_gene_g_3 3869_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59183 segment_4_hemagglutinin_(HA)_gene_g_4 3869_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59184 segment_4_hemagglutinin_(HA)_gene_g_5 3870_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59185 segment_4_hemagglutinin_(HA)_gene_g_1 3870_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59186 segment_4_hemagglutinin_(HA)_gene_g_2 3870_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59187 segment_4_hemagglutinin_(HA)_gene_g_3 3870_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59188 segment_4_hemagglutinin_(HA)_gene_g_4 3870_Influenza_A_virus_(A/California/07/2009(H1N1))_(—) 59189 segment_4_hemagglutinin_(HA)_gene_g_5 3871_Human_herpesvirus_6B_g_1 59190 3871_Human_herpesvirus_6B_g_2 59191 3871_Human_herpesvirus_6B_g_3 59192 3871_Human_herpesvirus_6B_g_4 59193 3871_Human_herpesvirus_6B_g_5 59194 3872_Human_herpesvirus_6B_g_1 59195 3872_Human_herpesvirus_6B_g_2 59196 3873_Human_herpesvirus_6B_g_1 59197 3873_Human_herpesvirus_6B_g_2 59198 3873_Human_herpesvirus_6B_g_3 59199 3875_Human_herpesvirus_6B_g_1 59200 3875_Human_herpesvirus_6B_g_2 59201 3875_Human_herpesvirus_6B_g_3 59202 3875_Human_herpesvirus_6B_g_4 59203 3875_Human_herpesvirus_6B_g_5 59204 3876_Human_herpesvirus_6B_g_1 59205 3876_Human_herpesvirus_6B_g_2 59206 3876_Human_herpesvirus_6B_g_3 59207 3876_Human_herpesvirus_6B_g_4 59208 3876_Human_herpesvirus_6B_g_5 59209 3877_Human_herpesvirus_6B_g_1 59210 3877_Human_herpesvirus_6B_g_2 59211 3877_Human_herpesvirus_6B_g_3 59212 3878_Human_herpesvirus_6B_g_1 59213 3878_Human_herpesvirus_6B_g_2 59214 3878_Human_herpesvirus_6B_g_3 59215 3878_Human_herpesvirus_6B_g_4 59216 3878_Human_herpesvirus_6B_g_5 59217 3879_Human_herpesvirus_6B_g_1 59218 3879_Human_herpesvirus_6B_g_2 59219 3879_Human_herpesvirus_6B_g_3 59220 3879_Human_herpesvirus_6B_g_4 59221 3879_Human_herpesvirus_6B_g_5 59222 3880_Human_herpesvirus_6B_g_1 59223 3880_Human_herpesvirus_6B_g_2 59224 3880_Human_herpesvirus_6B_g_3 59225 3881_Human_herpesvirus_6B_g_1 59226 3881_Human_herpesvirus_6B_g_2 59227 3881_Human_herpesvirus_6B_g_3 59228 3881_Human_herpesvirus_6B_g_4 59229 3881_Human_herpesvirus_6B_g_5 59230 3882_Human_herpesvirus_6B_g_1 59231 3882_Human_herpesvirus_6B_g_2 59232 3882_Human_herpesvirus_6B_g_3 59233 3882_Human_herpesvirus_6B_g_4 59234 3882_Human_herpesvirus_6B_g_5 59235 3883_Human_herpesvirus_6B_g_1 59236 3883_Human_herpesvirus_6B_g_2 59237 3883_Human_herpesvirus_6B_g_3 59238 3883_Human_herpesvirus_6B_g_4 59239 3883_Human_herpesvirus_6B_g_5 59240 3884_Human_herpesvirus_6B_g_1 59241 3884_Human_herpesvirus_6B_g_2 59242 3884_Human_herpesvirus_6B_g_3 59243 3884_Human_herpesvirus_6B_g_4 59244 3884_Human_herpesvirus_6B_g_5 59245 3885_Human_herpesvirus_6B_g_1 59246 3885_Human_herpesvirus_6B_g_2 59247 3885_Human_herpesvirus_6B_g_3 59248 3885_Human_herpesvirus_6B_g_4 59249 3885_Human_herpesvirus_6B_g_5 59250 3886_Human_herpesvirus_6B_g_1 59251 3886_Human_herpesvirus_6B_g_2 59252 3886_Human_herpesvirus_6B_g_3 59253 3886_Human_herpesvirus_6B_g_4 59254 3886_Human_herpesvirus_6B_g_5 59255 3887_Human_herpesvirus_6B_g_1 59256 3887_Human_herpesvirus_6B_g_2 59257 3887_Human_herpesvirus_6B_g_3 59258 3887_Human_herpesvirus_6B_g_4 59259 3887_Human_herpesvirus_6B_g_5 59260 3888_Human_herpesvirus_6B_g_1 59261 3888_Human_herpesvirus_6B_g_2 59262 3888_Human_herpesvirus_6B_g_3 59263 3888_Human_herpesvirus_6B_g_4 59264 3888_Human_herpesvirus_6B_g_5 59265 3889_Human_herpesvirus_6B_g_1 59266 3889_Human_herpesvirus_6B_g_2 59267 3889_Human_herpesvirus_6B_g_3 59268 3889_Human_herpesvirus_6B_g_4 59269 3889_Human_herpesvirus_6B_g_5 59270 3890_Human_herpesvirus_6B_g_1 59271 3890_Human_herpesvirus_6B_g_2 59272 3890_Human_herpesvirus_6B_g_3 59273 3890_Human_herpesvirus_6B_g_4 59274 3890_Human_herpesvirus_6B_g_5 59275 3891_Human_herpesvirus_6B_g_1 59276 3891_Human_herpesvirus_6B_g_2 59277 3891_Human_herpesvirus_6B_g_3 59278 3891_Human_herpesvirus_6B_g_4 59279 3891_Human_herpesvirus_6B_g_5 59280 3892_Human_herpesvirus_6B_g_1 59281 3892_Human_herpesvirus_6B_g_2 59282 3892_Human_herpesvirus_6B_g_3 59283 3892_Human_herpesvirus_6B_g_4 59284 3892_Human_herpesvirus_6B_g_5 59285 3893_Human_herpesvirus_6B_g_1 59286 3893_Human_herpesvirus_6B_g_2 59287 3893_Human_herpesvirus_6B_g_3 59288 3893_Human_herpesvirus_6B_g_4 59289 3893_Human_herpesvirus_6B_g_5 59290 3894_Human_herpesvirus_6B_g_1 59291 3894_Human_herpesvirus_6B_g_2 59292 3894_Human_herpesvirus_6B_g_3 59293 3894_Human_herpesvirus_6B_g_4 59294 3894_Human_herpesvirus_6B_g_5 59295 3895_Human_herpesvirus_6B_g_1 59296 3895_Human_herpesvirus_6B_g_2 59297 3895_Human_herpesvirus_6B_g_3 59298 3895_Human_herpesvirus_6B_g_4 59299 3895_Human_herpesvirus_6B_g_5 59300 3896_Human_herpesvirus_6B_g_1 59301 3896_Human_herpesvirus_6B_g_2 59302 3896_Human_herpesvirus_6B_g_3 59303 3896_Human_herpesvirus_6B_g_4 59304 3896_Human_herpesvirus_6B_g_5 59305 3897_Human_herpesvirus_6B_g_1 59306 3897_Human_herpesvirus_6B_g_2 59307 3897_Human_herpesvirus_6B_g_3 59308 3897_Human_herpesvirus_6B_g_4 59309 3897_Human_herpesvirus_6B_g_5 59310 3898_Human_herpesvirus_6B_g_1 59311 3898_Human_herpesvirus_6B_g_2 59312 3898_Human_herpesvirus_6B_g_3 59313 3898_Human_herpesvirus_6B_g_4 59314 3898_Human_herpesvirus_6B_g_5 59315 3899_Human_herpesvirus_6B_g_1 59316 3899_Human_herpesvirus_6B_g_2 59317 3899_Human_herpesvirus_6B_g_3 59318 3899_Human_herpesvirus_6B_g_4 59319 3899_Human_herpesvirus_6B_g_5 59320 3900_Human_herpesvirus_6B_g_1 59321 3900_Human_herpesvirus_6B_g_2 59322 3900_Human_herpesvirus_6B_g_3 59323 3900_Human_herpesvirus_6B_g_4 59324 3900_Human_herpesvirus_6B_g_5 59325 3901_Human_herpesvirus_6B_g_1 59326 3901_Human_herpesvirus_6B_g_2 59327 3901_Human_herpesvirus_6B_g_3 59328 3901_Human_herpesvirus_6B_g_4 59329 3901_Human_herpesvirus_6B_g_5 59330 3902_Human_herpesvirus_6B_g_1 59331 3903_Human_herpesvirus_6B_g_1 59332 3903_Human_herpesvirus_6B_g_2 59333 3903_Human_herpesvirus_6B_g_3 59334 3903_Human_herpesvirus_6B_g_4 59335 3904_Human_herpesvirus_6B_g_1 59336 3904_Human_herpesvirus_6B_g_2 59337 3904_Human_herpesvirus_6B_g_3 59338 3904_Human_herpesvirus_6B_g_4 59339 3904_Human_herpesvirus_6B_g_5 59340 3905_Human_herpesvirus_6B_g_1 59341 3905_Human_herpesvirus_6B_g_2 59342 3905_Human_herpesvirus_6B_g_3 59343 3905_Human_herpesvirus_6B_g_4 59344 3905_Human_herpesvirus_6B_g_5 59345 3906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59346 segment_7_g_1 3906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59347 segment_7_g_2 3906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59348 segment_7_g_3 3906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59349 segment_7_g_4 3906_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59350 segment_7_g_5 3907_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59351 segment_7_g_1 3907_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59352 segment_7_g_2 3907_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59353 segment_7_g_3 3907_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59354 segment_7_g_4 3907_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 59355 segment_7_g_5 3908_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59356 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_1 3908_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59357 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_2 3908_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59358 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_3 3908_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59359 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_4 3908_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59360 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_5 3909_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59361 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_1 3909_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59362 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_2 3909_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59363 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_3 3909_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59364 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_4 3909_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59365 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_5 3910_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59366 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_1 3910_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59367 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_2 3910_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59368 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_3 3910_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59369 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_4 3910_Influenza_A_virus_(A/California/07/2009(H1N1))_segment_8_nuclear_export_(—) 59370 protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_5 3911_Human_papillomavirus_type_7_genomic_DNA_g_1 59371 3911_Human_papillomavirus_type_7_genomic_DNA_g_2 59372 3911_Human_papillomavirus_type_7_genomic_DNA_g_3 59373 3911_Human_papillomavirus_type_7_genomic_DNA_g_4 59374 3911_Human_papillomavirus_type_7_genomic_DNA_g_5 59375 3912_Human_papillomavirus_type_7_genomic_DNA_g_1 59376 3912_Human_papillomavirus_type_7_genomic_DNA_g_2 59377 3912_Human_papillomavirus_type_7_genomic_DNA_g_3 59378 3912_Human_papillomavirus_type_7_genomic_DNA_g_4 59379 3912_Human_papillomavirus_type_7_genomic_DNA_g_5 59380 3913_Human_papillomavirus_type_7_genomic_DNA_g_1 59381 3913_Human_papillomavirus_type_7_genomic_DNA_g_2 59382 3913_Human_papillomavirus_type_7_genomic_DNA_g_3 59383 3913_Human_papillomavirus_type_7_genomic_DNA_g_4 59384 3913_Human_papillomavirus_type_7_genomic_DNA_g_5 59385 3914_Human_papillomavirus_type_7_genomic_DNA_g_1 59386 3914_Human_papillomavirus_type_7_genomic_DNA_g_2 59387 3914_Human_papillomavirus_type_7_genomic_DNA_g_3 59388 3914_Human_papillomavirus_type_7_genomic_DNA_g_4 59389 3914_Human_papillomavirus_type_7_genomic_DNA_g_5 59390 3915_Human_papillomavirus_type_7_genomic_DNA_g_1 59391 3915_Human_papillomavirus_type_7_genomic_DNA_g_2 59392 3915_Human_papillomavirus_type_7_genomic_DNA_g_3 59393 3915_Human_papillomavirus_type_7_genomic_DNA_g_4 59394 3915_Human_papillomavirus_type_7_genomic_DNA_g_5 59395 3916_Human_papillomavirus_type_7_genomic_DNA_g_1 59396 3916_Human_papillomavirus_type_7_genomic_DNA_g_2 59397 3916_Human_papillomavirus_type_7_genomic_DNA_g_3 59398 3916_Human_papillomavirus_type_7_genomic_DNA_g_4 59399 3916_Human_papillomavirus_type_7_genomic_DNA_g_5 59400 3917_Human_papillomavirus_type_7_genomic_DNA_g_1 59401 3917_Human_papillomavirus_type_7_genomic_DNA_g_2 59402 3917_Human_papillomavirus_type_7_genomic_DNA_g_3 59403 3917_Human_papillomavirus_type_7_genomic_DNA_g_4 59404 3917_Human_papillomavirus_type_7_genomic_DNA_g_5 59405 3918_Human_papillomavirus_type_7_genomic_DNA_g_1 59406 3918_Human_papillomavirus_type_7_genomic_DNA_g_2 59407 3918_Human_papillomavirus_type_7_genomic_DNA_g_3 59408 3918_Human_papillomavirus_type_7_genomic_DNA_g_4 59409 3918_Human_papillomavirus_type_7_genomic_DNA_g_5 59410 3919_Human_papillomavirus_type_7_genomic_DNA_g_1 59411 3919_Human_papillomavirus_type_7_genomic_DNA_g_2 59412 3919_Human_papillomavirus_type_7_genomic_DNA_g_3 59413 3919_Human_papillomavirus_type_7_genomic_DNA_g_4 59414 3919_Human_papillomavirus_type_7_genomic_DNA_g_5 59415 3920_Human_papillomavirus_type_7_genomic_DNA_g_1 59416 3920_Human_papillomavirus_type_7_genomic_DNA_g_2 59417 3920_Human_papillomavirus_type_7_genomic_DNA_g_3 59418 3920_Human_papillomavirus_type_7_genomic_DNA_g_4 59419 3920_Human_papillomavirus_type_7_genomic_DNA_g_5 59420 3921_Human_papillomavirus_type_7_genomic_DNA_g_1 59421 3921_Human_papillomavirus_type_7_genomic_DNA_g_2 59422 3921_Human_papillomavirus_type_7_genomic_DNA_g_3 59423 3921_Human_papillomavirus_type_7_genomic_DNA_g_4 59424 3921_Human_papillomavirus_type_7_genomic_DNA_g_5 59425 3922_Human_papillomavirus_type_7_genomic_DNA_g_1 59426 3922_Human_papillomavirus_type_7_genomic_DNA_g_2 59427 3922_Human_papillomavirus_type_7_genomic_DNA_g_3 59428 3922_Human_papillomavirus_type_7_genomic_DNA_g_4 59429 3922_Human_papillomavirus_type_7_genomic_DNA_g_5 59430 3923_Human_papillomavirus_type_7_genomic_DNA_g_1 59431 3923_Human_papillomavirus_type_7_genomic_DNA_g_2 59432 3923_Human_papillomavirus_type_7_genomic_DNA_g_3 59433 3923_Human_papillomavirus_type_7_genomic_DNA_g_4 59434 3923_Human_papillomavirus_type_7_genomic_DNA_g_5 59435 3924_Human_papillomavirus_type_7_genomic_DNA_g_1 59436 3924_Human_papillomavirus_type_7_genomic_DNA_g_2 59437 3924_Human_papillomavirus_type_7_genomic_DNA_g_3 59438 3924_Human_papillomavirus_type_7_genomic_DNA_g_4 59439 3924_Human_papillomavirus_type_7_genomic_DNA_g_5 59440 3925_Human_papillomavirus_type_7_genomic_DNA_g_1 59441 3925_Human_papillomavirus_type_7_genomic_DNA_g_2 59442 3925_Human_papillomavirus_type_7_genomic_DNA_g_3 59443 3925_Human_papillomavirus_type_7_genomic_DNA_g_4 59444 3925_Human_papillomavirus_type_7_genomic_DNA_g_5 59445 3926_Human_papillomavirus_type_7_genomic_DNA_g_1 59446 3926_Human_papillomavirus_type_7_genomic_DNA_g_2 59447 3926_Human_papillomavirus_type_7_genomic_DNA_g_3 59448 3926_Human_papillomavirus_type_7_genomic_DNA_g_4 59449 3926_Human_papillomavirus_type_7_genomic_DNA_g_5 59450 3927_Human_papillomavirus_type_53_g_1 59451 3927_Human_papillomavirus_type_53_g_2 59452 3927_Human_papillomavirus_type_53_g_3 59453 3927_Human_papillomavirus_type_53_g_4 59454 3927_Human_papillomavirus_type_53_g_5 59455 3928_Human_papillomavirus_type_53_g_1 59456 3928_Human_papillomavirus_type_53_g_2 59457 3928_Human_papillomavirus_type_53_g_3 59458 3928_Human_papillomavirus_type_53_g_4 59459 3928_Human_papillomavirus_type_53_g_5 59460 3929_Human_papillomavirus_type_53_g_1 59461 3929_Human_papillomavirus_type_53_g_2 59462 3929_Human_papillomavirus_type_53_g_3 59463 3929_Human_papillomavirus_type_53_g_4 59464 3929_Human_papillomavirus_type_53_g_5 59465 3930_Human_papillomavirus_type_53_g_1 59466 3930_Human_papillomavirus_type_53_g_2 59467 3930_Human_papillomavirus_type_53_g_3 59468 3930_Human_papillomavirus_type_53_g_4 59469 3930_Human_papillomavirus_type_53_g_5 59470 3931_Human_papillomavirus_type_53_g_1 59471 3931_Human_papillomavirus_type_53_g_2 59472 3931_Human_papillomavirus_type_53_g_3 59473 3931_Human_papillomavirus_type_53_g_4 59474 3931_Human_papillomavirus_type_53_g_5 59475 3932_Human_papillomavirus_type_53_g_1 59476 3932_Human_papillomavirus_type_53_g_2 59477 3932_Human_papillomavirus_type_53_g_3 59478 3932_Human_papillomavirus_type_53_g_4 59479 3932_Human_papillomavirus_type_53_g_5 59480 3933_Human_papillomavirus_type_53_g_1 59481 3933_Human_papillomavirus_type_53_g_2 59482 3933_Human_papillomavirus_type_53_g_3 59483 3933_Human_papillomavirus_type_53_g_4 59484 3933_Human_papillomavirus_type_53_g_5 59485 3934_Human_papillomavirus_type_53_g_1 59486 3934_Human_papillomavirus_type_53_g_2 59487 3934_Human_papillomavirus_type_53_g_3 59488 3934_Human_papillomavirus_type_53_g_4 59489 3934_Human_papillomavirus_type_53_g_5 59490 3935_Human_papillomavirus_type_53_g_1 59491 3935_Human_papillomavirus_type_53_g_2 59492 3935_Human_papillomavirus_type_53_g_3 59493 3935_Human_papillomavirus_type_53_g_4 59494 3935_Human_papillomavirus_type_53_g_5 59495 3936_Human_papillomavirus_type_53_g_1 59496 3936_Human_papillomavirus_type_53_g_2 59497 3936_Human_papillomavirus_type_53_g_3 59498 3936_Human_papillomavirus_type_53_g_4 59499 3937_Human_papillomavirus_type_53_g_1 59500 3937_Human_papillomavirus_type_53_g_2 59501 3937_Human_papillomavirus_type_53_g_3 59502 3937_Human_papillomavirus_type_53_g_4 59503 3937_Human_papillomavirus_type_53_g_5 59504 3938_Human_papillomavirus_type_53_g_1 59505 3938_Human_papillomavirus_type_53_g_2 59506 3938_Human_papillomavirus_type_53_g_3 59507 3938_Human_papillomavirus_type_53_g_4 59508 3938_Human_papillomavirus_type_53_g_5 59509 3939_Human_papillomavirus_type_53_g_1 59510 3939_Human_papillomavirus_type_53_g_2 59511 3939_Human_papillomavirus_type_53_g_3 59512 3939_Human_papillomavirus_type_53_g_4 59513 3939_Human_papillomavirus_type_53_g_5 59514 3940_Human_papillomavirus_type_53_g_1 59515 3940_Human_papillomavirus_type_53_g_2 59516 3940_Human_papillomavirus_type_53_g_3 59517 3940_Human_papillomavirus_type_53_g_4 59518 3940_Human_papillomavirus_type_53_g_5 59519 3941_Human_papillomavirus_type_53_g_1 59520 3941_Human_papillomavirus_type_53_g_2 59521 3941_Human_papillomavirus_type_53_g_3 59522 3941_Human_papillomavirus_type_53_g_4 59523 3941_Human_papillomavirus_type_53_g_5 59524 3942_Human_papillomavirus_type_53_g_1 59525 3942_Human_papillomavirus_type_53_g_2 59526 3942_Human_papillomavirus_type_53_g_3 59527 3942_Human_papillomavirus_type_53_g_4 59528 3942_Human_papillomavirus_type_53_g_5 59529 3943_Human_papillomavirus_type_53_g_1 59530 3943_Human_papillomavirus_type_53_g_2 59531 3943_Human_papillomavirus_type_53_g_3 59532 3943_Human_papillomavirus_type_53_g_4 59533 3943_Human_papillomavirus_type_53_g_5 59534 3944_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59535 3944_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59536 3944_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59537 3944_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59538 3944_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59539 3945_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59540 3945_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59541 3945_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59542 3945_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59543 3945_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59544 3946_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59545 3946_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59546 3946_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59547 3946_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59548 3946_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59549 3947_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59550 3947_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59551 3947_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59552 3947_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59553 3947_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59554 3948_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59555 3948_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59556 3948_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59557 3948_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59558 3948_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59559 3949_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59560 3949_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59561 3949_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59562 3949_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59563 3949_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59564 3950_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59565 3950_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59566 3950_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59567 3950_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59568 3950_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59569 3951_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59570 3951_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59571 3951_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59572 3951_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59573 3951_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59574 3952_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59575 3952_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59576 3952_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59577 3952_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59578 3952_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59579 3953_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59580 3953_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59581 3953_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59582 3953_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59583 3953_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59584 3954_Human_rhinovirus_1_strain_ATCC_VR-1559_g_1 59585 3954_Human_rhinovirus_1_strain_ATCC_VR-1559_g_2 59586 3954_Human_rhinovirus_1_strain_ATCC_VR-1559_g_3 59587 3954_Human_rhinovirus_1_strain_ATCC_VR-1559_g_4 59588 3954_Human_rhinovirus_1_strain_ATCC_VR-1559_g_5 59589 3955_Human_papillomavirus_type_166_isolate_KC9_g_1 59590 3955_Human_papillomavirus_type_166_isolate_KC9_g_2 59591 3955_Human_papillomavirus_type_166_isolate_KC9_g_3 59592 3955_Human_papillomavirus_type_166_isolate_KC9_g_4 59593 3955_Human_papillomavirus_type_166_isolate_KC9_g_5 59594 3956_Human_papillomavirus_type_166_isolate_KC9_g_1 59595 3956_Human_papillomavirus_type_166_isolate_KC9_g_2 59596 3956_Human_papillomavirus_type_166_isolate_KC9_g_3 59597 3956_Human_papillomavirus_type_166_isolate_KC9_g_4 59598 3956_Human_papillomavirus_type_166_isolate_KC9_g_5 59599 3957_Human_papillomavirus_type_166_isolate_KC9_g_1 59600 3957_Human_papillomavirus_type_166_isolate_KC9_g_2 59601 3957_Human_papillomavirus_type_166_isolate_KC9_g_3 59602 3957_Human_papillomavirus_type_166_isolate_KC9_g_4 59603 3957_Human_papillomavirus_type_166_isolate_KC9_g_5 59604 3958_Human_papillomavirus_type_166_isolate_KC9_g_1 59605 3958_Human_papillomavirus_type_166_isolate_KC9_g_2 59606 3958_Human_papillomavirus_type_166_isolate_KC9_g_3 59607 3958_Human_papillomavirus_type_166_isolate_KC9_g_4 59608 3958_Human_papillomavirus_type_166_isolate_KC9_g_5 59609 3959_Human_papillomavirus_type_166_isolate_KC9_g_1 59610 3959_Human_papillomavirus_type_166_isolate_KC9_g_2 59611 3959_Human_papillomavirus_type_166_isolate_KC9_g_3 59612 3959_Human_papillomavirus_type_166_isolate_KC9_g_4 59613 3959_Human_papillomavirus_type_166_isolate_KC9_g_5 59614 3960_Human_papillomavirus_type_166_isolate_KC9_g_1 59615 3960_Human_papillomavirus_type_166_isolate_KC9_g_2 59616 3960_Human_papillomavirus_type_166_isolate_KC9_g_3 59617 3960_Human_papillomavirus_type_166_isolate_KC9_g_4 59618 3960_Human_papillomavirus_type_166_isolate_KC9_g_5 59619 3961_Human_papillomavirus_type_166_isolate_KC9_g_1 59620 3961_Human_papillomavirus_type_166_isolate_KC9_g_2 59621 3961_Human_papillomavirus_type_166_isolate_KC9_g_3 59622 3961_Human_papillomavirus_type_166_isolate_KC9_g_4 59623 3961_Human_papillomavirus_type_166_isolate_KC9_g_5 59624 3962_Human_papillomavirus_type_166_isolate_KC9_g_1 59625 3962_Human_papillomavirus_type_166_isolate_KC9_g_2 59626 3962_Human_papillomavirus_type_166_isolate_KC9_g_3 59627 3962_Human_papillomavirus_type_166_isolate_KC9_g_4 59628 3962_Human_papillomavirus_type_166_isolate_KC9_g_5 59629 3963_Human_papillomavirus_type_166_isolate_KC9_g_1 59630 3963_Human_papillomavirus_type_166_isolate_KC9_g_2 59631 3963_Human_papillomavirus_type_166_isolate_KC9_g_3 59632 3963_Human_papillomavirus_type_166_isolate_KC9_g_4 59633 3963_Human_papillomavirus_type_166_isolate_KC9_g_5 59634 3964_Human_papillomavirus_type_166_isolate_KC9_g_1 59635 3964_Human_papillomavirus_type_166_isolate_KC9_g_2 59636 3964_Human_papillomavirus_type_166_isolate_KC9_g_3 59637 3964_Human_papillomavirus_type_166_isolate_KC9_g_4 59638 3964_Human_papillomavirus_type_166_isolate_KC9_g_5 59639 3965_Human_papillomavirus_type_166_isolate_KC9_g_1 59640 3965_Human_papillomavirus_type_166_isolate_KC9_g_2 59641 3965_Human_papillomavirus_type_166_isolate_KC9_g_3 59642 3965_Human_papillomavirus_type_166_isolate_KC9_g_4 59643 3965_Human_papillomavirus_type_166_isolate_KC9_g_5 59644 3966_Human_papillomavirus_type_166_isolate_KC9_g_1 59645 3966_Human_papillomavirus_type_166_isolate_KC9_g_2 59646 3966_Human_papillomavirus_type_166_isolate_KC9_g_3 59647 3966_Human_papillomavirus_type_166_isolate_KC9_g_4 59648 3966_Human_papillomavirus_type_166_isolate_KC9_g_5 59649 3967_Human_papillomavirus_type_166_isolate_KC9_g_1 59650 3967_Human_papillomavirus_type_166_isolate_KC9_g_2 59651 3967_Human_papillomavirus_type_166_isolate_KC9_g_3 59652 3967_Human_papillomavirus_type_166_isolate_KC9_g_4 59653 3967_Human_papillomavirus_type_166_isolate_KC9_g_5 59654 3968_Human_papillomavirus_type_166_isolate_KC9_g_1 59655 3968_Human_papillomavirus_type_166_isolate_KC9_g_2 59656 3968_Human_papillomavirus_type_166_isolate_KC9_g_3 59657 3968_Human_papillomavirus_type_166_isolate_KC9_g_4 59658 3968_Human_papillomavirus_type_166_isolate_KC9_g_5 59659 3969_Human_papillomavirus_type_166_isolate_KC9_g_1 59660 3969_Human_papillomavirus_type_166_isolate_KC9_g_2 59661 3969_Human_papillomavirus_type_166_isolate_KC9_g_3 59662 3969_Human_papillomavirus_type_166_isolate_KC9_g_4 59663 3969_Human_papillomavirus_type_166_isolate_KC9_g_5 59664 3970_Human_rhinovirus_C_g_1 59665 3970_Human_rhinovirus_C_g_2 59666 3970_Human_rhinovirus_C_g_3 59667 3970_Human_rhinovirus_C_g_4 59668 3970_Human_rhinovirus_C_g_5 59669 3971_Human_rhinovirus_C_g_1 59670 3971_Human_rhinovirus_C_g_2 59671 3971_Human_rhinovirus_C_g_3 59672 3971_Human_rhinovirus_C_g_4 59673 3971_Human_rhinovirus_C_g_5 59674 3972_Human_rhinovirus_C_g_1 59675 3972_Human_rhinovirus_C_g_2 59676 3972_Human_rhinovirus_C_g_3 59677 3972_Human_rhinovirus_C_g_4 59678 3972_Human_rhinovirus_C_g_5 59679 3973_Human_rhinovirus_C_g_1 59680 3973_Human_rhinovirus_C_g_2 59681 3973_Human_rhinovirus_C_g_3 59682 3973_Human_rhinovirus_C_g_4 59683 3973_Human_rhinovirus_C_g_5 59684 3974_Human_rhinovirus_C_g_1 59685 3974_Human_rhinovirus_C_g_2 59686 3974_Human_rhinovirus_C_g_3 59687 3974_Human_rhinovirus_C_g_4 59688 3974_Human_rhinovirus_C_g_5 59689 3975_Human_rhinovirus_C_g_1 59690 3975_Human_rhinovirus_C_g_2 59691 3975_Human_rhinovirus_C_g_3 59692 3975_Human_rhinovirus_C_g_4 59693 3975_Human_rhinovirus_C_g_5 59694 3976_Human_rhinovirus_C_g_1 59695 3976_Human_rhinovirus_C_g_2 59696 3976_Human_rhinovirus_C_g_3 59697 3976_Human_rhinovirus_C_g_4 59698 3976_Human_rhinovirus_C_g_5 59699 3977_Human_rhinovirus_C_g_1 59700 3977_Human_rhinovirus_C_g_2 59701 3977_Human_rhinovirus_C_g_3 59702 3977_Human_rhinovirus_C_g_4 59703 3977_Human_rhinovirus_C_g_5 59704 3978_Human_rhinovirus_C_g_1 59705 3978_Human_rhinovirus_C_g_2 59706 3978_Human_rhinovirus_C_g_3 59707 3978_Human_rhinovirus_C_g_4 59708 3978_Human_rhinovirus_C_g_5 59709 3979_Human_rhinovirus_C_g_1 59710 3979_Human_rhinovirus_C_g_2 59711 3979_Human_rhinovirus_C_g_3 59712 3979_Human_rhinovirus_C_g_4 59713 3979_Human_rhinovirus_C_g_5 59714 3980_Human_rhinovirus_C_g_1 59715 3980_Human_rhinovirus_C_g_2 59716 3980_Human_rhinovirus_C_g_3 59717 3980_Human_rhinovirus_C_g_4 59718 3980_Human_rhinovirus_C_g_5 59719 3981_Human_rhinovirus_C_g_1 59720 3981_Human_rhinovirus_C_g_2 59721 3981_Human_rhinovirus_C_g_3 59722 3981_Human_rhinovirus_C_g_4 59723 3981_Human_rhinovirus_C_g_5 59724 3982_Human_rhinovirus_C_g_1 59725 3982_Human_rhinovirus_C_g_2 59726 3982_Human_rhinovirus_C_g_3 59727 3982_Human_rhinovirus_C_g_4 59728 3982_Human_rhinovirus_C_g_5 59729 3983_Human_rhinovirus_C_g_1 59730 3983_Human_rhinovirus_C_g_2 59731 3983_Human_rhinovirus_C_g_3 59732 3983_Human_rhinovirus_C_g_4 59733 3983_Human_rhinovirus_C_g_5 59734 3984_Human_rhinovirus_C_g_1 59735 3984_Human_rhinovirus_C_g_2 59736 3984_Human_rhinovirus_C_g_3 59737 3984_Human_rhinovirus_C_g_4 59738 3984_Human_rhinovirus_C_g_5 59739 3985_Human_rhinovirus_C_g_1 59740 3985_Human_rhinovirus_C_g_2 59741 3985_Human_rhinovirus_C_g_3 59742 3985_Human_rhinovirus_C_g_4 59743 3985_Human_rhinovirus_C_g_5 59744 3986_Human_rhinovirus_C_g_1 59745 3986_Human_rhinovirus_C_g_2 59746 3986_Human_rhinovirus_C_g_3 59747 3986_Human_rhinovirus_C_g_4 59748 3986_Human_rhinovirus_C_g_5 59749 3987_Human_rhinovirus_C_g_1 59750 3987_Human_rhinovirus_C_g_2 59751 3987_Human_rhinovirus_C_g_3 59752 3987_Human_rhinovirus_C_g_4 59753 3987_Human_rhinovirus_C_g_5 59754 3988_Human_rhinovirus_C_g_1 59755 3988_Human_rhinovirus_C_g_2 59756 3988_Human_rhinovirus_C_g_3 59757 3988_Human_rhinovirus_C_g_4 59758 3988_Human_rhinovirus_C_g_5 59759 3989_Human_rhinovirus_C_g_1 59760 3989_Human_rhinovirus_C_g_2 59761 3989_Human_rhinovirus_C_g_3 59762 3989_Human_rhinovirus_C_g_4 59763 3989_Human_rhinovirus_C_g_5 59764 3990_Human_rhinovirus_C_g_1 59765 3990_Human_rhinovirus_C_g_2 59766 3990_Human_rhinovirus_C_g_3 59767 3990_Human_rhinovirus_C_g_4 59768 3990_Human_rhinovirus_C_g_5 59769 3991_Human_rhinovirus_C_g_1 59770 3991_Human_rhinovirus_C_g_2 59771 3991_Human_rhinovirus_C_g_3 59772 3991_Human_rhinovirus_C_g_4 59773 3991_Human_rhinovirus_C_g_5 59774 3992_Human_rhinovirus_C_g_1 59775 3992_Human_rhinovirus_C_g_2 59776 3992_Human_rhinovirus_C_g_3 59777 3992_Human_rhinovirus_C_g_4 59778 3992_Human_rhinovirus_C_g_5 59779 3993_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59780 polymerase_(PB2)_gene_g_1 3993_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59781 polymerase_(PB2)_gene_g_2 3993_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59782 polymerase_(PB2)_gene_g_3 3993_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59783 polymerase_(PB2)_gene_g_4 3993_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59784 polymerase_(PB2)_gene_g_5 3994_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59785 polymerase_(PB2)_gene_g_1 3994_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59786 polymerase_(PB2)_gene_g_2 3994_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59787 polymerase_(PB2)_gene_g_3 3994_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59788 polymerase_(PB2)_gene_g_4 3994_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59789 polymerase_(PB2)_gene_g_5 3995_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59790 polymerase_(PB2)_gene_g_1 3995_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59791 polymerase_(PB2)_gene_g_2 3995_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59792 polymerase_(PB2)_gene_g_3 3995_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59793 polymerase_(PB2)_gene_g_4 3995_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59794 polymerase_(PB2)_gene_g_5 3996_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59795 polymerase_(PB2)_gene_g_1 3996_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59796 polymerase_(PB2)_gene_g_2 3996_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59797 polymerase_(PB2)_gene_g_3 3996_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59798 polymerase_(PB2)_gene_g_4 3996_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59799 polymerase_(PB2)_gene_g_5 3997_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59800 polymerase_(PB2)_gene_g_1 3997_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59801 polymerase_(PB2)_gene_g_2 3997_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59802 polymerase_(PB2)_gene_g_3 3997_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59803 polymerase_(PB2)_gene_g_4 3997_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59804 polymerase_(PB2)_gene_g_5 3998_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59805 polymerase_(PB2)_gene_g_1 3998_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59806 polymerase_(PB2)_gene_g_2 3998_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59807 polymerase_(PB2)_gene_g_3 3998_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59808 polymerase_(PB2)_gene_g_4 3998_Influenza_A_virus_(A/Goose/Guangdong/1/96(H5N1))_(—) 59809 polymerase_(PB2)_gene_g_5 3999_Human_adenovirus_54_g_1 59810 3999_Human_adenovirus_54_g_2 59811 3999_Human_adenovirus_54_g_3 59812 3999_Human_adenovirus_54_g_4 59813 3999_Human_adenovirus_54_g_5 59814 4000_Human_adenovirus_54_g_1 59815 4000_Human_adenovirus_54_g_2 59816 4000_Human_adenovirus_54_g_3 59817 4000_Human_adenovirus_54_g_4 59818 4000_Human_adenovirus_54_g_5 59819 4001_Human_adenovirus_54_g_1 59820 4001_Human_adenovirus_54_g_2 59821 4001_Human_adenovirus_54_g_3 59822 4001_Human_adenovirus_54_g_4 59823 4001_Human_adenovirus_54_g_5 59824 4002_Human_adenovirus_54_g_1 59825 4002_Human_adenovirus_54_g_2 59826 4002_Human_adenovirus_54_g_3 59827 4002_Human_adenovirus_54_g_4 59828 4002_Human_adenovirus_54_g_5 59829 4003_Human_adenovirus_54_g_1 59830 4003_Human_adenovirus_54_g_2 59831 4003_Human_adenovirus_54_g_3 59832 4003_Human_adenovirus_54_g_4 59833 4003_Human_adenovirus_54_g_5 59834 4004_Human_adenovirus_54_g_1 59835 4004_Human_adenovirus_54_g_2 59836 4004_Human_adenovirus_54_g_3 59837 4004_Human_adenovirus_54_g_4 59838 4004_Human_adenovirus_54_g_5 59839 4005_Human_adenovirus_54_g_1 59840 4005_Human_adenovirus_54_g_2 59841 4005_Human_adenovirus_54_g_3 59842 4005_Human_adenovirus_54_g_4 59843 4005_Human_adenovirus_54_g_5 59844 4006_Human_adenovirus_54_g_1 59845 4006_Human_adenovirus_54_g_2 59846 4006_Human_adenovirus_54_g_3 59847 4006_Human_adenovirus_54_g_4 59848 4006_Human_adenovirus_54_g_5 59849 4007_Human_adenovirus_54_g_1 59850 4007_Human_adenovirus_54_g_2 59851 4007_Human_adenovirus_54_g_3 59852 4007_Human_adenovirus_54_g_4 59853 4007_Human_adenovirus_54_g_5 59854 4008_Human_adenovirus_54_g_1 59855 4008_Human_adenovirus_54_g_2 59856 4008_Human_adenovirus_54_g_3 59857 4008_Human_adenovirus_54_g_4 59858 4008_Human_adenovirus_54_g_5 59859 4009_Human_adenovirus_54_g_1 59860 4009_Human_adenovirus_54_g_2 59861 4009_Human_adenovirus_54_g_3 59862 4009_Human_adenovirus_54_g_4 59863 4009_Human_adenovirus_54_g_5 59864 4010_Human_adenovirus_54_g_1 59865 4010_Human_adenovirus_54_g_2 59866 4010_Human_adenovirus_54_g_3 59867 4010_Human_adenovirus_54_g_4 59868 4010_Human_adenovirus_54_g_5 59869 4011_Human_adenovirus_54_g_1 59870 4011_Human_adenovirus_54_g_2 59871 4011_Human_adenovirus_54_g_3 59872 4011_Human_adenovirus_54_g_4 59873 4011_Human_adenovirus_54_g_5 59874 4012_Human_adenovirus_54_g_1 59875 4012_Human_adenovirus_54_g_2 59876 4012_Human_adenovirus_54_g_3 59877 4012_Human_adenovirus_54_g_4 59878 4012_Human_adenovirus_54_g_5 59879 4013_Human_adenovirus_54_g_1 59880 4013_Human_adenovirus_54_g_2 59881 4013_Human_adenovirus_54_g_3 59882 4013_Human_adenovirus_54_g_4 59883 4013_Human_adenovirus_54_g_5 59884 4014_Human_adenovirus_54_g_1 59885 4014_Human_adenovirus_54_g_2 59886 4014_Human_adenovirus_54_g_3 59887 4014_Human_adenovirus_54_g_4 59888 4014_Human_adenovirus_54_g_5 59889 4015_Human_adenovirus_54_g_1 59890 4015_Human_adenovirus_54_g_2 59891 4015_Human_adenovirus_54_g_3 59892 4015_Human_adenovirus_54_g_4 59893 4015_Human_adenovirus_54_g_5 59894 4016_Human_adenovirus_54_g_1 59895 4016_Human_adenovirus_54_g_2 59896 4016_Human_adenovirus_54_g_3 59897 4016_Human_adenovirus_54_g_4 59898 4016_Human_adenovirus_54_g_5 59899 4017_Human_adenovirus_54_g_1 59900 4017_Human_adenovirus_54_g_2 59901 4017_Human_adenovirus_54_g_3 59902 4018_Human_adenovirus_54_g_1 59903 4018_Human_adenovirus_54_g_2 59904 4018_Human_adenovirus_54_g_3 59905 4018_Human_adenovirus_54_g_4 59906 4018_Human_adenovirus_54_g_5 59907 4019_Human_adenovirus_54_g_1 59908 4019_Human_adenovirus_54_g_2 59909 4019_Human_adenovirus_54_g_3 59910 4019_Human_adenovirus_54_g_4 59911 4019_Human_adenovirus_54_g_5 59912 4020_Human_adenovirus_54_g_1 59913 4020_Human_adenovirus_54_g_2 59914 4020_Human_adenovirus_54_g_3 59915 4020_Human_adenovirus_54_g_4 59916 4020_Human_adenovirus_54_g_5 59917 4021_Human_adenovirus_54_g_1 59918 4021_Human_adenovirus_54_g_2 59919 4021_Human_adenovirus_54_g_3 59920 4021_Human_adenovirus_54_g_4 59921 4021_Human_adenovirus_54_g_5 59922 4022_Human_adenovirus_54_g_1 59923 4022_Human_adenovirus_54_g_2 59924 4022_Human_adenovirus_54_g_3 59925 4022_Human_adenovirus_54_g_4 59926 4022_Human_adenovirus_54_g_5 59927 4023_Human_adenovirus_54_g_1 59928 4023_Human_adenovirus_54_g_2 59929 4023_Human_adenovirus_54_g_3 59930 4023_Human_adenovirus_54_g_4 59931 4023_Human_adenovirus_54_g_5 59932 4024_Human_adenovirus_54_g_1 59933 4024_Human_adenovirus_54_g_2 59934 4024_Human_adenovirus_54_g_3 59935 4024_Human_adenovirus_54_g_4 59936 4024_Human_adenovirus_54_g_5 59937 4025_Human_adenovirus_54_g_1 59938 4025_Human_adenovirus_54_g_2 59939 4025_Human_adenovirus_54_g_3 59940 4025_Human_adenovirus_54_g_4 59941 4025_Human_adenovirus_54_g_5 59942 4026_Human_adenovirus_54_g_1 59943 4026_Human_adenovirus_54_g_2 59944 4026_Human_adenovirus_54_g_3 59945 4026_Human_adenovirus_54_g_4 59946 4026_Human_adenovirus_54_g_5 59947 4027_Human_adenovirus_54_g_1 59948 4027_Human_adenovirus_54_g_2 59949 4027_Human_adenovirus_54_g_3 59950 4027_Human_adenovirus_54_g_4 59951 4027_Human_adenovirus_54_g_5 59952 4028_Human_adenovirus_54_g_1 59953 4028_Human_adenovirus_54_g_2 59954 4029_Human_adenovirus_54_g_1 59955 4029_Human_adenovirus_54_g_2 59956 4029_Human_adenovirus_54_g_3 59957 4029_Human_adenovirus_54_g_4 59958 4029_Human_adenovirus_54_g_5 59959 4030_Human_adenovirus_54_g_1 59960 4030_Human_adenovirus_54_g_2 59961 4030_Human_adenovirus_54_g_3 59962 4030_Human_adenovirus_54_g_4 59963 4030_Human_adenovirus_54_g_5 59964 4031_Human_adenovirus_54_g_1 59965 4031_Human_adenovirus_54_g_2 59966 4031_Human_adenovirus_54_g_3 59967 4031_Human_adenovirus_54_g_4 59968 4031_Human_adenovirus_54_g_5 59969 4032_Human_adenovirus_54_g_1 59970 4032_Human_adenovirus_54_g_2 59971 4032_Human_adenovirus_54_g_3 59972 4032_Human_adenovirus_54_g_4 59973 4032_Human_adenovirus_54_g_5 59974 4033_Human_adenovirus_54_g_1 59975 4033_Human_adenovirus_54_g_2 59976 4033_Human_adenovirus_54_g_3 59977 4033_Human_adenovirus_54_g_4 59978 4033_Human_adenovirus_54_g_5 59979 4034_Human_adenovirus_54_g_1 59980 4034_Human_adenovirus_54_g_2 59981 4034_Human_adenovirus_54_g_3 59982 4034_Human_adenovirus_54_g_4 59983 4035_Human_adenovirus_54_g_1 59984 4035_Human_adenovirus_54_g_2 59985 4035_Human_adenovirus_54_g_3 59986 4035_Human_adenovirus_54_g_4 59987 4035_Human_adenovirus_54_g_5 59988 4036_Human_adenovirus_54_g_1 59989 4036_Human_adenovirus_54_g_2 59990 4036_Human_adenovirus_54_g_3 59991 4036_Human_adenovirus_54_g_4 59992 4036_Human_adenovirus_54_g_5 59993 4037_Human_adenovirus_54_g_1 59994 4037_Human_adenovirus_54_g_2 59995 4037_Human_adenovirus_54_g_3 59996 4037_Human_adenovirus_54_g_4 59997 4037_Human_adenovirus_54_g_5 59998 4038_Human_adenovirus_54_g_1 59999 4038_Human_adenovirus_54_g_2 60000 4038_Human_adenovirus_54_g_3 60001 4038_Human_adenovirus_54_g_4 60002 4038_Human_adenovirus_54_g_5 60003 4039_Human_adenovirus_54_g_1 60004 4039_Human_adenovirus_54_g_2 60005 4039_Human_adenovirus_54_g_3 60006 4039_Human_adenovirus_54_g_4 60007 4040_Human_adenovirus_54_g_1 60008 4040_Human_adenovirus_54_g_2 60009 4040_Human_adenovirus_54_g_3 60010 4040_Human_adenovirus_54_g_4 60011 4040_Human_adenovirus_54_g_5 60012 4041_Human_adenovirus_54_g_1 60013 4041_Human_adenovirus_54_g_2 60014 4041_Human_adenovirus_54_g_3 60015 4041_Human_adenovirus_54_g_4 60016 4041_Human_adenovirus_54_g_5 60017 4042_Human_adenovirus_54_g_1 60018 4042_Human_adenovirus_54_g_2 60019 4042_Human_adenovirus_54_g_3 60020 4042_Human_adenovirus_54_g_4 60021 4042_Human_adenovirus_54_g_5 60022 4043_Human_adenovirus_54_g_1 60023 4043_Human_adenovirus_54_g_2 60024 4043_Human_adenovirus_54_g_3 60025 4043_Human_adenovirus_54_g_4 60026 4043_Human_adenovirus_54_g_5 60027 4044_Human_adenovirus_54_g_1 60028 4044_Human_adenovirus_54_g_2 60029 4045_Human_adenovirus_54_g_1 60030 4045_Human_adenovirus_54_g_2 60031 4045_Human_adenovirus_54_g_3 60032 4046_Human_adenovirus_54_g_1 60033 4046_Human_adenovirus_54_g_2 60034 4046_Human_adenovirus_54_g_3 60035 4046_Human_adenovirus_54_g_4 60036 4046_Human_adenovirus_54_g_5 60037 4047_Human_adenovirus_54_g_1 60038 4047_Human_adenovirus_54_g_2 60039 4047_Human_adenovirus_54_g_3 60040 4047_Human_adenovirus_54_g_4 60041 4047_Human_adenovirus_54_g_5 60042 4048_Human_adenovirus_54_g_1 60043 4048_Human_adenovirus_54_g_2 60044 4048_Human_adenovirus_54_g_3 60045 4048_Human_adenovirus_54_g_4 60046 4048_Human_adenovirus_54_g_5 60047 4049_Human_adenovirus_54_g_1 60048 4049_Human_adenovirus_54_g_2 60049 4049_Human_adenovirus_54_g_3 60050 4049_Human_adenovirus_54_g_4 60051 4049_Human_adenovirus_54_g_5 60052 4050_Human_adenovirus_54_g_1 60053 4050_Human_adenovirus_54_g_2 60054 4050_Human_adenovirus_54_g_3 60055 4050_Human_adenovirus_54_g_4 60056 4050_Human_adenovirus_54_g_5 60057 4051_Human_adenovirus_54_g_1 60058 4051_Human_adenovirus_54_g_2 60059 4051_Human_adenovirus_54_g_3 60060 4052_Human_adenovirus_54_g_1 60061 4052_Human_adenovirus_54_g_2 60062 4052_Human_adenovirus_54_g_3 60063 4052_Human_adenovirus_54_g_4 60064 4052_Human_adenovirus_54_g_5 60065 4053_Human_adenovirus_54_g_1 60066 4053_Human_adenovirus_54_g_2 60067 4053_Human_adenovirus_54_g_3 60068 4053_Human_adenovirus_54_g_4 60069 4053_Human_adenovirus_54_g_5 60070 4054_Human_adenovirus_54_g_1 60071 4054_Human_adenovirus_54_g_2 60072 4054_Human_adenovirus_54_g_3 60073 4054_Human_adenovirus_54_g_4 60074 4054_Human_adenovirus_54_g_5 60075 4055_Human_adenovirus_54_g_1 60076 4055_Human_adenovirus_54_g_2 60077 4055_Human_adenovirus_54_g_3 60078 4055_Human_adenovirus_54_g_4 60079 4055_Human_adenovirus_54_g_5 60080 4056_Human_adenovirus_54_g_1 60081 4056_Human_adenovirus_54_g_2 60082 4056_Human_adenovirus_54_g_3 60083 4056_Human_adenovirus_54_g_4 60084 4056_Human_adenovirus_54_g_5 60085 4057_Human_adenovirus_54_g_1 60086 4057_Human_adenovirus_54_g_2 60087 4057_Human_adenovirus_54_g_3 60088 4057_Human_adenovirus_54_g_4 60089 4057_Human_adenovirus_54_g_5 60090 4058_Human_adenovirus_54_g_1 60091 4058_Human_adenovirus_54_g_2 60092 4058_Human_adenovirus_54_g_3 60093 4058_Human_adenovirus_54_g_4 60094 4058_Human_adenovirus_54_g_5 60095 4059_Human_adenovirus_54_g_1 60096 4059_Human_adenovirus_54_g_2 60097 4059_Human_adenovirus_54_g_3 60098 4060_Human_adenovirus_54_g_1 60099 4060_Human_adenovirus_54_g_2 60100 4060_Human_adenovirus_54_g_3 60101 4060_Human_adenovirus_54_g_4 60102 4060_Human_adenovirus_54_g_5 60103 4061_Human_adenovirus_54_g_1 60104 4061_Human_adenovirus_54_g_2 60105 4061_Human_adenovirus_54_g_3 60106 4061_Human_adenovirus_54_g_4 60107 4061_Human_adenovirus_54_g_5 60108 4062_Human_adenovirus_54_g_1 60109 4062_Human_adenovirus_54_g_2 60110 4062_Human_adenovirus_54_g_3 60111 4062_Human_adenovirus_54_g_4 60112 4063_Human_adenovirus_54_g_1 60113 4063_Human_adenovirus_54_g_2 60114 4063_Human_adenovirus_54_g_3 60115 4063_Human_adenovirus_54_g_4 60116 4063_Human_adenovirus_54_g_5 60117 4064_Human_adenovirus_54_g_1 60118 4064_Human_adenovirus_54_g_2 60119 4064_Human_adenovirus_54_g_3 60120 4064_Human_adenovirus_54_g_4 60121 4064_Human_adenovirus_54_g_5 60122 4065_Human_adenovirus_54_g_1 60123 4065_Human_adenovirus_54_g_2 60124 4065_Human_adenovirus_54_g_3 60125 4065_Human_adenovirus_54_g_4 60126 4066_Human_adenovirus_54_g_1 60127 4066_Human_adenovirus_54_g_2 60128 4066_Human_adenovirus_54_g_3 60129 4066_Human_adenovirus_54_g_4 60130 4066_Human_adenovirus_54_g_5 60131 4067_Human_adenovirus_54_g_1 60132 4067_Human_adenovirus_54_g_2 60133 4067_Human_adenovirus_54_g_3 60134 4067_Human_adenovirus_54_g_4 60135 4067_Human_adenovirus_54_g_5 60136 4068_Human_adenovirus_54_g_1 60137 4068_Human_adenovirus_54_g_2 60138 4068_Human_adenovirus_54_g_3 60139 4068_Human_adenovirus_54_g_4 60140 4068_Human_adenovirus_54_g_5 60141 4069_Human_adenovirus_54_g_1 60142 4069_Human_adenovirus_54_g_2 60143 4069_Human_adenovirus_54_g_3 60144 4069_Human_adenovirus_54_g_4 60145 4069_Human_adenovirus_54_g_5 60146 4070_Human_adenovirus_54_g_1 60147 4070_Human_adenovirus_54_g_2 60148 4070_Human_adenovirus_54_g_3 60149 4070_Human_adenovirus_54_g_4 60150 4070_Human_adenovirus_54_g_5 60151 4071_Human_adenovirus_54_g_1 60152 4071_Human_adenovirus_54_g_2 60153 4071_Human_adenovirus_54_g_3 60154 4071_Human_adenovirus_54_g_4 60155 4071_Human_adenovirus_54_g_5 60156 4072_Human_adenovirus_54_g_1 60157 4072_Human_adenovirus_54_g_2 60158 4072_Human_adenovirus_54_g_3 60159 4072_Human_adenovirus_54_g_4 60160 4073_Human_adenovirus_54_g_1 60161 4073_Human_adenovirus_54_g_2 60162 4073_Human_adenovirus_54_g_3 60163 4073_Human_adenovirus_54_g_4 60164 4073_Human_adenovirus_54_g_5 60165 4074_Human_adenovirus_54_g_1 60166 4074_Human_adenovirus_54_g_2 60167 4074_Human_adenovirus_54_g_3 60168 4074_Human_adenovirus_54_g_4 60169 4075_Human_adenovirus_54_g_1 60170 4075_Human_adenovirus_54_g_2 60171 4075_Human_adenovirus_54_g_3 60172 4075_Human_adenovirus_54_g_4 60173 4075_Human_adenovirus_54_g_5 60174 4076_Human_adenovirus_54_g_1 60175 4076_Human_adenovirus_54_g_2 60176 4076_Human_adenovirus_54_g_3 60177 4076_Human_adenovirus_54_g_4 60178 4076_Human_adenovirus_54_g_5 60179 4077_Human_adenovirus_54_g_1 60180 4077_Human_adenovirus_54_g_2 60181 4077_Human_adenovirus_54_g_3 60182 4077_Human_adenovirus_54_g_4 60183 4077_Human_adenovirus_54_g_5 60184 4078_Human_adenovirus_54_g_1 60185 4078_Human_adenovirus_54_g_2 60186 4078_Human_adenovirus_54_g_3 60187 4078_Human_adenovirus_54_g_4 60188 4078_Human_adenovirus_54_g_5 60189 4079_Human_adenovirus_54_g_1 60190 4079_Human_adenovirus_54_g_2 60191 4079_Human_adenovirus_54_g_3 60192 4079_Human_adenovirus_54_g_4 60193 4079_Human_adenovirus_54_g_5 60194 4080_Human_adenovirus_54_g_1 60195 4080_Human_adenovirus_54_g_2 60196 4080_Human_adenovirus_54_g_3 60197 4080_Human_adenovirus_54_g_4 60198 4080_Human_adenovirus_54_g_5 60199 4081_Human_adenovirus_54_g_1 60200 4081_Human_adenovirus_54_g_2 60201 4081_Human_adenovirus_54_g_3 60202 4081_Human_adenovirus_54_g_4 60203 4081_Human_adenovirus_54_g_5 60204 4082_Human_adenovirus_54_g_1 60205 4082_Human_adenovirus_54_g_2 60206 4082_Human_adenovirus_54_g_3 60207 4082_Human_adenovirus_54_g_4 60208 4082_Human_adenovirus_54_g_5 60209 4083_Human_adenovirus_54_g_1 60210 4083_Human_adenovirus_54_g_2 60211 4083_Human_adenovirus_54_g_3 60212 4083_Human_adenovirus_54_g_4 60213 4083_Human_adenovirus_54_g_5 60214 4084_Human_adenovirus_54_g_1 60215 4084_Human_adenovirus_54_g_2 60216 4084_Human_adenovirus_54_g_3 60217 4084_Human_adenovirus_54_g_4 60218 4084_Human_adenovirus_54_g_5 60219 4085_Human_adenovirus_54_g_1 60220 4085_Human_adenovirus_54_g_2 60221 4085_Human_adenovirus_54_g_3 60222 4085_Human_adenovirus_54_g_4 60223 4085_Human_adenovirus_54_g_5 60224 4086_Human_adenovirus_54_g_1 60225 4086_Human_adenovirus_54_g_2 60226 4086_Human_adenovirus_54_g_3 60227 4086_Human_adenovirus_54_g_4 60228 4086_Human_adenovirus_54_g_5 60229 4087_Human_adenovirus_54_g_1 60230 4087_Human_adenovirus_54_g_2 60231 4087_Human_adenovirus_54_g_3 60232 4087_Human_adenovirus_54_g_4 60233 4087_Human_adenovirus_54_g_5 60234 4088_Human_adenovirus_54_g_1 60235 4088_Human_adenovirus_54_g_2 60236 4088_Human_adenovirus_54_g_3 60237 4088_Human_adenovirus_54_g_4 60238 4088_Human_adenovirus_54_g_5 60239 4089_Human_adenovirus_54_g_1 60240 4089_Human_adenovirus_54_g_2 60241 4089_Human_adenovirus_54_g_3 60242 4089_Human_adenovirus_54_g_4 60243 4089_Human_adenovirus_54_g_5 60244 4090_Human_adenovirus_54_g_1 60245 4090_Human_adenovirus_54_g_2 60246 4090_Human_adenovirus_54_g_3 60247 4090_Human_adenovirus_54_g_4 60248 4090_Human_adenovirus_54_g_5 60249 4091_Human_adenovirus_54_g_1 60250 4091_Human_adenovirus_54_g_2 60251 4091_Human_adenovirus_54_g_3 60252 4091_Human_adenovirus_54_g_4 60253 4091_Human_adenovirus_54_g_5 60254 4092_Human_adenovirus_54_g_1 60255 4092_Human_adenovirus_54_g_2 60256 4092_Human_adenovirus_54_g_3 60257 4092_Human_adenovirus_54_g_4 60258 4092_Human_adenovirus_54_g_5 60259 4093_Human_adenovirus_54_g_1 60260 4093_Human_adenovirus_54_g_2 60261 4093_Human_adenovirus_54_g_3 60262 4093_Human_adenovirus_54_g_4 60263 4093_Human_adenovirus_54_g_5 60264 4094_Human_adenovirus_54_g_1 60265 4094_Human_adenovirus_54_g_2 60266 4094_Human_adenovirus_54_g_3 60267 4094_Human_adenovirus_54_g_4 60268 4094_Human_adenovirus_54_g_5 60269 4095_Human_adenovirus_54_g_1 60270 4095_Human_adenovirus_54_g_2 60271 4095_Human_adenovirus_54_g_3 60272 4095_Human_adenovirus_54_g_4 60273 4095_Human_adenovirus_54_g_5 60274 4096_Human_adenovirus_54_g_1 60275 4096_Human_adenovirus_54_g_2 60276 4096_Human_adenovirus_54_g_3 60277 4096_Human_adenovirus_54_g_4 60278 4096_Human_adenovirus_54_g_5 60279 4097_Human_adenovirus_54_g_1 60280 4097_Human_adenovirus_54_g_2 60281 4097_Human_adenovirus_54_g_3 60282 4097_Human_adenovirus_54_g_4 60283 4097_Human_adenovirus_54_g_5 60284 4098_Human_adenovirus_54_g_1 60285 4098_Human_adenovirus_54_g_2 60286 4098_Human_adenovirus_54_g_3 60287 4098_Human_adenovirus_54_g_4 60288 4098_Human_adenovirus_54_g_5 60289 4099_Human_parainfluenza_virus_1_g_1 60290 4099_Human_parainfluenza_virus_1_g_2 60291 4099_Human_parainfluenza_virus_1_g_3 60292 4099_Human_parainfluenza_virus_1_g_4 60293 4099_Human_parainfluenza_virus_1_g_5 60294 4100_Human_parainfluenza_virus_1_g_1 60295 4100_Human_parainfluenza_virus_1_g_2 60296 4100_Human_parainfluenza_virus_1_g_3 60297 4100_Human_parainfluenza_virus_1_g_4 60298 4100_Human_parainfluenza_virus_1_g_5 60299 4101_Human_parainfluenza_virus_1_g_1 60300 4101_Human_parainfluenza_virus_1_g_2 60301 4101_Human_parainfluenza_virus_1_g_3 60302 4101_Human_parainfluenza_virus_1_g_4 60303 4101_Human_parainfluenza_virus_1_g_5 60304 4102_Human_parainfluenza_virus_1_g_1 60305 4102_Human_parainfluenza_virus_1_g_2 60306 4102_Human_parainfluenza_virus_1_g_3 60307 4102_Human_parainfluenza_virus_1_g_4 60308 4102_Human_parainfluenza_virus_1_g_5 60309 4103_Human_parainfluenza_virus_1_g_1 60310 4103_Human_parainfluenza_virus_1_g_2 60311 4103_Human_parainfluenza_virus_1_g_3 60312 4103_Human_parainfluenza_virus_1_g_4 60313 4103_Human_parainfluenza_virus_1_g_5 60314 4104_Human_parainfluenza_virus_1_g_1 60315 4104_Human_parainfluenza_virus_1_g_2 60316 4104_Human_parainfluenza_virus_1_g_3 60317 4104_Human_parainfluenza_virus_1_g_4 60318 4104_Human_parainfluenza_virus_1_g_5 60319 4105_Human_parainfluenza_virus_1_g_1 60320 4105_Human_parainfluenza_virus_1_g_2 60321 4105_Human_parainfluenza_virus_1_g_3 60322 4105_Human_parainfluenza_virus_1_g_4 60323 4105_Human_parainfluenza_virus_1_g_5 60324 4106_Human_parainfluenza_virus_1_g_1 60325 4106_Human_parainfluenza_virus_1_g_2 60326 4106_Human_parainfluenza_virus_1_g_3 60327 4106_Human_parainfluenza_virus_1_g_4 60328 4106_Human_parainfluenza_virus_1_g_5 60329 4107_Human_parainfluenza_virus_1_g_1 60330 4107_Human_parainfluenza_virus_1_g_2 60331 4107_Human_parainfluenza_virus_1_g_3 60332 4107_Human_parainfluenza_virus_1_g_4 60333 4107_Human_parainfluenza_virus_1_g_5 60334 4108_Human_parainfluenza_virus_1_g_1 60335 4108_Human_parainfluenza_virus_1_g_2 60336 4108_Human_parainfluenza_virus_1_g_3 60337 4108_Human_parainfluenza_virus_1_g_4 60338 4108_Human_parainfluenza_virus_1_g_5 60339 4109_Human_parainfluenza_virus_1_g_1 60340 4109_Human_parainfluenza_virus_1_g_2 60341 4109_Human_parainfluenza_virus_1_g_3 60342 4109_Human_parainfluenza_virus_1_g_4 60343 4109_Human_parainfluenza_virus_1_g_5 60344 4110_Human_parainfluenza_virus_1_g_1 60345 4110_Human_parainfluenza_virus_1_g_2 60346 4110_Human_parainfluenza_virus_1_g_3 60347 4110_Human_parainfluenza_virus_1_g_4 60348 4110_Human_parainfluenza_virus_1_g_5 60349 4111_Human_parainfluenza_virus_1_g_1 60350 4111_Human_parainfluenza_virus_1_g_2 60351 4111_Human_parainfluenza_virus_1_g_3 60352 4111_Human_parainfluenza_virus_1_g_4 60353 4111_Human_parainfluenza_virus_1_g_5 60354 4112_Human_parainfluenza_virus_1_g_1 60355 4112_Human_parainfluenza_virus_1_g_2 60356 4112_Human_parainfluenza_virus_1_g_3 60357 4112_Human_parainfluenza_virus_1_g_4 60358 4112_Human_parainfluenza_virus_1_g_5 60359 4113_Human_parainfluenza_virus_1_g_1 60360 4113_Human_parainfluenza_virus_1_g_2 60361 4113_Human_parainfluenza_virus_1_g_3 60362 4113_Human_parainfluenza_virus_1_g_4 60363 4113_Human_parainfluenza_virus_1_g_5 60364 4114_Human_parainfluenza_virus_1_g_1 60365 4114_Human_parainfluenza_virus_1_g_2 60366 4114_Human_parainfluenza_virus_1_g_3 60367 4114_Human_parainfluenza_virus_1_g_4 60368 4114_Human_parainfluenza_virus_1_g_5 60369 4115_Human_parainfluenza_virus_1_g_1 60370 4115_Human_parainfluenza_virus_1_g_2 60371 4115_Human_parainfluenza_virus_1_g_3 60372 4115_Human_parainfluenza_virus_1_g_4 60373 4115_Human_parainfluenza_virus_1_g_5 60374 4116_Human_parainfluenza_virus_1_g_1 60375 4116_Human_parainfluenza_virus_1_g_2 60376 4116_Human_parainfluenza_virus_1_g_3 60377 4116_Human_parainfluenza_virus_1_g_4 60378 4116_Human_parainfluenza_virus_1_g_5 60379 4117_Human_parainfluenza_virus_1_g_1 60380 4117_Human_parainfluenza_virus_1_g_2 60381 4117_Human_parainfluenza_virus_1_g_3 60382 4117_Human_parainfluenza_virus_1_g_4 60383 4117_Human_parainfluenza_virus_1_g_5 60384 4118_Human_parainfluenza_virus_1_g_1 60385 4118_Human_parainfluenza_virus_1_g_2 60386 4118_Human_parainfluenza_virus_1_g_3 60387 4118_Human_parainfluenza_virus_1_g_4 60388 4118_Human_parainfluenza_virus_1_g_5 60389 4119_Human_parainfluenza_virus_1_g_1 60390 4119_Human_parainfluenza_virus_1_g_2 60391 4119_Human_parainfluenza_virus_1_g_3 60392 4119_Human_parainfluenza_virus_1_g_4 60393 4119_Human_parainfluenza_virus_1_g_5 60394 4120_Human_parainfluenza_virus_1_g_1 60395 4120_Human_parainfluenza_virus_1_g_2 60396 4120_Human_parainfluenza_virus_1_g_3 60397 4120_Human_parainfluenza_virus_1_g_4 60398 4120_Human_parainfluenza_virus_1_g_5 60399 4121_Human_parainfluenza_virus_1_g_1 60400 4121_Human_parainfluenza_virus_1_g_2 60401 4121_Human_parainfluenza_virus_1_g_3 60402 4121_Human_parainfluenza_virus_1_g_4 60403 4121_Human_parainfluenza_virus_1_g_5 60404 4122_Human_parainfluenza_virus_1_g_1 60405 4122_Human_parainfluenza_virus_1_g_2 60406 4122_Human_parainfluenza_virus_1_g_3 60407 4122_Human_parainfluenza_virus_1_g_4 60408 4122_Human_parainfluenza_virus_1_g_5 60409 4123_Human_parainfluenza_virus_1_g_1 60410 4123_Human_parainfluenza_virus_1_g_2 60411 4123_Human_parainfluenza_virus_1_g_3 60412 4123_Human_parainfluenza_virus_1_g_4 60413 4123_Human_parainfluenza_virus_1_g_5 60414 4124_Human_parainfluenza_virus_1_g_1 60415 4124_Human_parainfluenza_virus_1_g_2 60416 4124_Human_parainfluenza_virus_1_g_3 60417 4124_Human_parainfluenza_virus_1_g_4 60418 4124_Human_parainfluenza_virus_1_g_5 60419 4125_Human_parainfluenza_virus_1_g_1 60420 4125_Human_parainfluenza_virus_1_g_2 60421 4125_Human_parainfluenza_virus_1_g_3 60422 4125_Human_parainfluenza_virus_1_g_4 60423 4125_Human_parainfluenza_virus_1_g_5 60424 4126_Human_parainfluenza_virus_1_g_1 60425 4126_Human_parainfluenza_virus_1_g_2 60426 4126_Human_parainfluenza_virus_1_g_3 60427 4126_Human_parainfluenza_virus_1_g_4 60428 4126_Human_parainfluenza_virus_1_g_5 60429 4127_Human_parainfluenza_virus_1_g_1 60430 4127_Human_parainfluenza_virus_1_g_2 60431 4127_Human_parainfluenza_virus_1_g_3 60432 4127_Human_parainfluenza_virus_1_g_4 60433 4127_Human_parainfluenza_virus_1_g_5 60434 4128_Human_parainfluenza_virus_1_g_1 60435 4128_Human_parainfluenza_virus_1_g_2 60436 4128_Human_parainfluenza_virus_1_g_3 60437 4128_Human_parainfluenza_virus_1_g_4 60438 4128_Human_parainfluenza_virus_1_g_5 60439 4129_Human_parainfluenza_virus_1_g_1 60440 4129_Human_parainfluenza_virus_1_g_2 60441 4129_Human_parainfluenza_virus_1_g_3 60442 4129_Human_parainfluenza_virus_1_g_4 60443 4129_Human_parainfluenza_virus_1_g_5 60444 4130_Human_parainfluenza_virus_1_g_1 60445 4130_Human_parainfluenza_virus_1_g_2 60446 4130_Human_parainfluenza_virus_1_g_3 60447 4130_Human_parainfluenza_virus_1_g_4 60448 4130_Human_parainfluenza_virus_1_g_5 60449 4131_Human_parainfluenza_virus_1_g_1 60450 4131_Human_parainfluenza_virus_1_g_2 60451 4131_Human_parainfluenza_virus_1_g_3 60452 4131_Human_parainfluenza_virus_1_g_4 60453 4131_Human_parainfluenza_virus_1_g_5 60454 4132_Human_parainfluenza_virus_1_g_1 60455 4132_Human_parainfluenza_virus_1_g_2 60456 4132_Human_parainfluenza_virus_1_g_3 60457 4132_Human_parainfluenza_virus_1_g_4 60458 4132_Human_parainfluenza_virus_1_g_5 60459 4133_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60460 segment_2_g_1 4133_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60461 segment_2_g_2 4133_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60462 segment_2_g_3 4133_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60463 segment_2_g_4 4133_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60464 segment_2_g_5 4134_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60465 segment_2_g_1 4134_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60466 segment_2_g_2 4134_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60467 segment_2_g_3 4134_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60468 segment_2_g_4 4134_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60469 segment_2_g_5 4135_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60470 segment_2_g_1 4135_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60471 segment_2_g_2 4135_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60472 segment_2_g_3 4135_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60473 segment_2_g_4 4135_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60474 segment_2_g_5 4136_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60475 segment_2_g_1 4136_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60476 segment_2_g_2 4136_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60477 segment_2_g_3 4136_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60478 segment_2_g_4 4136_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60479 segment_2_g_5 4137_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60480 segment_2_g_1 4137_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60481 segment_2_g_2 4137_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60482 segment_2_g_3 4137_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60483 segment_2_g_4 4137_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60484 segment_2_g_5 4138_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60485 segment_2_g_1 4138_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60486 segment_2_g_2 4138_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60487 segment_2_g_3 4138_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60488 segment_2_g_4 4138_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60489 segment_2_g_5 4139_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60490 segment_2_g_1 4139_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60491 segment_2_g_2 4139_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60492 segment_2_g_3 4139_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60493 segment_2_g_4 4139_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60494 segment_2_g_5 4140_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60495 segment_2_g_1 4140_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60496 segment_2_g_2 4140_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60497 segment_2_g_3 4140_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60498 segment_2_g_4 4140_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60499 segment_2_g_5 4141_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60500 segment_2_g_1 4141_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60501 segment_2_g_2 4141_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60502 segment_2_g_3 4141_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60503 segment_2_g_4 4141_Influenza_A_virus_(A/Korea/426/1968(H2N2))_(—) 60504 segment_2_g_5 4142_Human_papillomavirus_—_61_g_1 60505 4142_Human_papillomavirus_—_61_g_2 60506 4142_Human_papillomavirus_—_61_g_3 60507 4142_Human_papillomavirus_—_61_g_4 60508 4142_Human_papillomavirus_—_61_g_5 60509 4143_Human_papillomavirus_—_61_g_1 60510 4143_Human_papillomavirus_—_61_g_2 60511 4143_Human_papillomavirus_—_61_g_3 60512 4143_Human_papillomavirus_—_61_g_4 60513 4143_Human_papillomavirus_—_61_g_5 60514 4144_Human_papillomavirus_—_61_g_1 60515 4144_Human_papillomavirus_—_61_g_2 60516 4144_Human_papillomavirus_—_61_g_3 60517 4144_Human_papillomavirus_—_61_g_4 60518 4144_Human_papillomavirus_—_61_g_5 60519 4145_Human_papillomavirus_—_61_g_1 60520 4145_Human_papillomavirus_—_61_g_2 60521 4145_Human_papillomavirus_—_61_g_3 60522 4145_Human_papillomavirus_—_61_g_4 60523 4145_Human_papillomavirus_—_61_g_5 60524 4146_Human_papillomavirus_—_61_g_1 60525 4146_Human_papillomavirus_—_61_g_2 60526 4146_Human_papillomavirus_—_61_g_3 60527 4146_Human_papillomavirus_—_61_g_4 60528 4146_Human_papillomavirus_—_61_g_5 60529 4147_Human_papillomavirus_—_61_g_1 60530 4147_Human_papillomavirus_—_61_g_2 60531 4147_Human_papillomavirus_—_61_g_3 60532 4147_Human_papillomavirus_—_61_g_4 60533 4147_Human_papillomavirus_—_61_g_5 60534 4148_Human_papillomavirus_—_61_g_1 60535 4148_Human_papillomavirus_—_61_g_2 60536 4148_Human_papillomavirus_—_61_g_3 60537 4148_Human_papillomavirus_—_61_g_4 60538 4148_Human_papillomavirus_—_61_g_5 60539 4149_Human_papillomavirus_—_61_g_1 60540 4149_Human_papillomavirus_—_61_g_2 60541 4149_Human_papillomavirus_—_61_g_3 60542 4149_Human_papillomavirus_—_61_g_4 60543 4149_Human_papillomavirus_—_61_g_5 60544 4150_Human_papillomavirus_—_61_g_1 60545 4150_Human_papillomavirus_—_61_g_2 60546 4150_Human_papillomavirus_—_61_g_3 60547 4150_Human_papillomavirus_—_61_g_4 60548 4150_Human_papillomavirus_—_61_g_5 60549 4151_Human_papillomavirus_—_61_g_1 60550 4151_Human_papillomavirus_—_61_g_2 60551 4151_Human_papillomavirus_—_61_g_3 60552 4151_Human_papillomavirus_—_61_g_4 60553 4151_Human_papillomavirus_—_61_g_5 60554 4152_Human_papillomavirus_—_61_g_1 60555 4152_Human_papillomavirus_—_61_g_2 60556 4153_Human_papillomavirus_—_61_g_1 60557 4153_Human_papillomavirus_—_61_g_2 60558 4153_Human_papillomavirus_—_61_g_3 60559 4153_Human_papillomavirus_—_61_g_4 60560 4153_Human_papillomavirus_—_61_g_5 60561 4154_Human_papillomavirus_—_61_g_1 60562 4154_Human_papillomavirus_—_61_g_2 60563 4154_Human_papillomavirus_—_61_g_3 60564 4154_Human_papillomavirus_—_61_g_4 60565 4154_Human_papillomavirus_—_61_g_5 60566 4155_Human_papillomavirus_—_61_g_1 60567 4155_Human_papillomavirus_—_61_g_2 60568 4155_Human_papillomavirus_—_61_g_3 60569 4155_Human_papillomavirus_—_61_g_4 60570 4155_Human_papillomavirus_—_61_g_5 60571 4156_Human_papillomavirus_—_61_g_1 60572 4156_Human_papillomavirus_—_61_g_2 60573 4156_Human_papillomavirus_—_61_g_3 60574 4156_Human_papillomavirus_—_61_g_4 60575 4156_Human_papillomavirus_—_61_g_5 60576 4157_Human_papillomavirus_—_61_g_1 60577 4157_Human_papillomavirus_—_61_g_2 60578 4157_Human_papillomavirus_—_61_g_3 60579 4157_Human_papillomavirus_—_61_g_4 60580 4157_Human_papillomavirus_—_61_g_5 60581 4158_Human_papillomavirus_—_61_g_1 60582 4158_Human_papillomavirus_—_61_g_2 60583 4158_Human_papillomavirus_—_61_g_3 60584 4158_Human_papillomavirus_—_61_g_4 60585 4158_Human_papillomavirus_—_61_g_5 60586 4159_Human_papillomavirus_—_61_g_1 60587 4159_Human_papillomavirus_—_61_g_2 60588 4159_Human_papillomavirus_—_61_g_3 60589 4159_Human_papillomavirus_—_61_g_4 60590 4159_Human_papillomavirus_—_61_g_5 60591 4160_Human_papillomavirus_—_61_g_1 60592 4160_Human_papillomavirus_—_61_g_2 60593 4160_Human_papillomavirus_—_61_g_3 60594 4160_Human_papillomavirus_—_61_g_4 60595 4160_Human_papillomavirus_—_61_g_5 60596 4161_Human_papillomavirus_—_61_g_1 60597 4161_Human_papillomavirus_—_61_g_2 60598 4161_Human_papillomavirus_—_61_g_3 60599 4161_Human_papillomavirus_—_61_g_4 60600 4161_Human_papillomavirus_—_61_g_5 60601 4162_Human_papillomavirus_—_61_g_1 60602 4162_Human_papillomavirus_—_61_g_2 60603 4162_Human_papillomavirus_—_61_g_3 60604 4162_Human_papillomavirus_—_61_g_4 60605 4162_Human_papillomavirus_—_61_g_5 60606 4163_Human_herpesvirus_8_strain_GK18_g_1 60607 4163_Human_herpesvirus_8_strain_GK18_g_2 60608 4163_Human_herpesvirus_8_strain_GK18_g_3 60609 4163_Human_herpesvirus_8_strain_GK18_g_4 60610 4163_Human_herpesvirus_8_strain_GK18_g_5 60611 4164_Human_herpesvirus_8_strain_GK18_g_1 60612 4164_Human_herpesvirus_8_strain_GK18_g_2 60613 4164_Human_herpesvirus_8_strain_GK18_g_3 60614 4164_Human_herpesvirus_8_strain_GK18_g_4 60615 4164_Human_herpesvirus_8_strain_GK18_g_5 60616 4165_Human_herpesvirus_8_strain_GK18_g_1 60617 4165_Human_herpesvirus_8_strain_GK18_g_2 60618 4165_Human_herpesvirus_8_strain_GK18_g_3 60619 4165_Human_herpesvirus_8_strain_GK18_g_4 60620 4165_Human_herpesvirus_8_strain_GK18_g_5 60621 4166_Human_herpesvirus_8_strain_GK18_g_1 60622 4166_Human_herpesvirus_8_strain_GK18_g_2 60623 4166_Human_herpesvirus_8_strain_GK18_g_3 60624 4166_Human_herpesvirus_8_strain_GK18_g_4 60625 4166_Human_herpesvirus_8_strain_GK18_g_5 60626 4167_Human_herpesvirus_8_strain_GK18_g_1 60627 4167_Human_herpesvirus_8_strain_GK18_g_2 60628 4167_Human_herpesvirus_8_strain_GK18_g_3 60629 4167_Human_herpesvirus_8_strain_GK18_g_4 60630 4167_Human_herpesvirus_8_strain_GK18_g_5 60631 4168_Human_herpesvirus_8_strain_GK18_g_1 60632 4168_Human_herpesvirus_8_strain_GK18_g_2 60633 4168_Human_herpesvirus_8_strain_GK18_g_3 60634 4168_Human_herpesvirus_8_strain_GK18_g_4 60635 4168_Human_herpesvirus_8_strain_GK18_g_5 60636 4169_Human_herpesvirus_8_strain_GK18_g_1 60637 4169_Human_herpesvirus_8_strain_GK18_g_2 60638 4169_Human_herpesvirus_8_strain_GK18_g_3 60639 4169_Human_herpesvirus_8_strain_GK18_g_4 60640 4169_Human_herpesvirus_8_strain_GK18_g_5 60641 4170_Human_herpesvirus_8_strain_GK18_g_1 60642 4170_Human_herpesvirus_8_strain_GK18_g_2 60643 4170_Human_herpesvirus_8_strain_GK18_g_3 60644 4170_Human_herpesvirus_8_strain_GK18_g_4 60645 4170_Human_herpesvirus_8_strain_GK18_g_5 60646 4172_Human_herpesvirus_8_strain_GK18_g_1 60647 4172_Human_herpesvirus_8_strain_GK18_g_2 60648 4172_Human_herpesvirus_8_strain_GK18_g_3 60649 4172_Human_herpesvirus_8_strain_GK18_g_4 60650 4172_Human_herpesvirus_8_strain_GK18_g_5 60651 4173_Human_herpesvirus_8_strain_GK18_g_1 60652 4173_Human_herpesvirus_8_strain_GK18_g_2 60653 4173_Human_herpesvirus_8_strain_GK18_g_3 60654 4173_Human_herpesvirus_8_strain_GK18_g_4 60655 4173_Human_herpesvirus_8_strain_GK18_g_5 60656 4174_Human_herpesvirus_8_strain_GK18_g_1 60657 4174_Human_herpesvirus_8_strain_GK18_g_2 60658 4174_Human_herpesvirus_8_strain_GK18_g_3 60659 4174_Human_herpesvirus_8_strain_GK18_g_4 60660 4174_Human_herpesvirus_8_strain_GK18_g_5 60661 4175_Human_herpesvirus_8_strain_GK18_g_1 60662 4175_Human_herpesvirus_8_strain_GK18_g_2 60663 4175_Human_herpesvirus_8_strain_GK18_g_3 60664 4175_Human_herpesvirus_8_strain_GK18_g_4 60665 4175_Human_herpesvirus_8_strain_GK18_g_5 60666 4176_Human_herpesvirus_8_strain_GK18_g_1 60667 4176_Human_herpesvirus_8_strain_GK18_g_2 60668 4176_Human_herpesvirus_8_strain_GK18_g_3 60669 4176_Human_herpesvirus_8_strain_GK18_g_4 60670 4176_Human_herpesvirus_8_strain_GK18_g_5 60671 4177_Human_herpesvirus_8_strain_GK18_g_1 60672 4177_Human_herpesvirus_8_strain_GK18_g_2 60673 4177_Human_herpesvirus_8_strain_GK18_g_3 60674 4178_Human_herpesvirus_8_strain_GK18_g_1 60675 4178_Human_herpesvirus_8_strain_GK18_g_2 60676 4178_Human_herpesvirus_8_strain_GK18_g_3 60677 4178_Human_herpesvirus_8_strain_GK18_g_4 60678 4178_Human_herpesvirus_8_strain_GK18_g_5 60679 4179_Human_herpesvirus_8_strain_GK18_g_1 60680 4179_Human_herpesvirus_8_strain_GK18_g_2 60681 4179_Human_herpesvirus_8_strain_GK18_g_3 60682 4179_Human_herpesvirus_8_strain_GK18_g_4 60683 4179_Human_herpesvirus_8_strain_GK18_g_5 60684 4180_Human_herpesvirus_8_strain_GK18_g_1 60685 4180_Human_herpesvirus_8_strain_GK18_g_2 60686 4180_Human_herpesvirus_8_strain_GK18_g_3 60687 4180_Human_herpesvirus_8_strain_GK18_g_4 60688 4180_Human_herpesvirus_8_strain_GK18_g_5 60689 4181_Human_herpesvirus_8_strain_GK18_g_1 60690 4181_Human_herpesvirus_8_strain_GK18_g_2 60691 4181_Human_herpesvirus_8_strain_GK18_g_3 60692 4181_Human_herpesvirus_8_strain_GK18_g_4 60693 4181_Human_herpesvirus_8_strain_GK18_g_5 60694 4182_Human_herpesvirus_8_strain_GK18_g_1 60695 4182_Human_herpesvirus_8_strain_GK18_g_2 60696 4182_Human_herpesvirus_8_strain_GK18_g_3 60697 4182_Human_herpesvirus_8_strain_GK18_g_4 60698 4182_Human_herpesvirus_8_strain_GK18_g_5 60699 4183_Human_herpesvirus_8_strain_GK18_g_1 60700 4183_Human_herpesvirus_8_strain_GK18_g_2 60701 4183_Human_herpesvirus_8_strain_GK18_g_3 60702 4183_Human_herpesvirus_8_strain_GK18_g_4 60703 4183_Human_herpesvirus_8_strain_GK18_g_5 60704 4184_Human_herpesvirus_8_strain_GK18_g_1 60705 4184_Human_herpesvirus_8_strain_GK18_g_2 60706 4184_Human_herpesvirus_8_strain_GK18_g_3 60707 4184_Human_herpesvirus_8_strain_GK18_g_4 60708 4185_Human_herpesvirus_8_strain_GK18_g_1 60709 4185_Human_herpesvirus_8_strain_GK18_g_2 60710 4185_Human_herpesvirus_8_strain_GK18_g_3 60711 4185_Human_herpesvirus_8_strain_GK18_g_4 60712 4185_Human_herpesvirus_8_strain_GK18_g_5 60713 4186_Human_herpesvirus_8_strain_GK18_g_1 60714 4186_Human_herpesvirus_8_strain_GK18_g_2 60715 4186_Human_herpesvirus_8_strain_GK18_g_3 60716 4186_Human_herpesvirus_8_strain_GK18_g_4 60717 4186_Human_herpesvirus_8_strain_GK18_g_5 60718 4187_Human_herpesvirus_8_strain_GK18_g_1 60719 4187_Human_herpesvirus_8_strain_GK18_g_2 60720 4187_Human_herpesvirus_8_strain_GK18_g_3 60721 4187_Human_herpesvirus_8_strain_GK18_g_4 60722 4187_Human_herpesvirus_8_strain_GK18_g_5 60723 4188_Human_herpesvirus_8_strain_GK18_g_1 60724 4188_Human_herpesvirus_8_strain_GK18_g_2 60725 4188_Human_herpesvirus_8_strain_GK18_g_3 60726 4189_Human_herpesvirus_8_strain_GK18_g_1 60727 4189_Human_herpesvirus_8_strain_GK18_g_2 60728 4189_Human_herpesvirus_8_strain_GK18_g_3 60729 4189_Human_herpesvirus_8_strain_GK18_g_4 60730 4190_Human_herpesvirus_8_strain_GK18_g_1 60731 4190_Human_herpesvirus_8_strain_GK18_g_2 60732 4190_Human_herpesvirus_8_strain_GK18_g_3 60733 4190_Human_herpesvirus_8_strain_GK18_g_4 60734 4191_Human_herpesvirus_8_strain_GK18_g_1 60735 4191_Human_herpesvirus_8_strain_GK18_g_2 60736 4191_Human_herpesvirus_8_strain_GK18_g_3 60737 4191_Human_herpesvirus_8_strain_GK18_g_4 60738 4191_Human_herpesvirus_8_strain_GK18_g_5 60739 4192_Human_herpesvirus_8_strain_GK18_g_1 60740 4192_Human_herpesvirus_8_strain_GK18_g_2 60741 4192_Human_herpesvirus_8_strain_GK18_g_3 60742 4193_Human_herpesvirus_8_strain_GK18_g_1 60743 4193_Human_herpesvirus_8_strain_GK18_g_2 60744 4193_Human_herpesvirus_8_strain_GK18_g_3 60745 4193_Human_herpesvirus_8_strain_GK18_g_4 60746 4193_Human_herpesvirus_8_strain_GK18_g_5 60747 4194_Human_herpesvirus_8_strain_GK18_g_1 60748 4194_Human_herpesvirus_8_strain_GK18_g_2 60749 4194_Human_herpesvirus_8_strain_GK18_g_3 60750 4194_Human_herpesvirus_8_strain_GK18_g_4 60751 4194_Human_herpesvirus_8_strain_GK18_g_5 60752 4195_Human_herpesvirus_8_strain_GK18_g_1 60753 4195_Human_herpesvirus_8_strain_GK18_g_2 60754 4195_Human_herpesvirus_8_strain_GK18_g_3 60755 4195_Human_herpesvirus_8_strain_GK18_g_4 60756 4195_Human_herpesvirus_8_strain_GK18_g_5 60757 4196_Human_herpesvirus_8_strain_GK18_g_1 60758 4196_Human_herpesvirus_8_strain_GK18_g_2 60759 4196_Human_herpesvirus_8_strain_GK18_g_3 60760 4196_Human_herpesvirus_8_strain_GK18_g_4 60761 4196_Human_herpesvirus_8_strain_GK18_g_5 60762 4198_Human_herpesvirus_8_strain_GK18_g_1 60763 4198_Human_herpesvirus_8_strain_GK18_g_2 60764 4198_Human_herpesvirus_8_strain_GK18_g_3 60765 4198_Human_herpesvirus_8_strain_GK18_g_4 60766 4198_Human_herpesvirus_8_strain_GK18_g_5 60767 4199_Human_herpesvirus_8_strain_GK18_g_1 60768 4199_Human_herpesvirus_8_strain_GK18_g_2 60769 4199_Human_herpesvirus_8_strain_GK18_g_3 60770 4199_Human_herpesvirus_8_strain_GK18_g_4 60771 4200_Human_herpesvirus_8_strain_GK18_g_1 60772 4200_Human_herpesvirus_8_strain_GK18_g_2 60773 4200_Human_herpesvirus_8_strain_GK18_g_3 60774 4200_Human_herpesvirus_8_strain_GK18_g_4 60775 4200_Human_herpesvirus_8_strain_GK18_g_5 60776 4201_Human_herpesvirus_8_strain_GK18_g_1 60777 4201_Human_herpesvirus_8_strain_GK18_g_2 60778 4201_Human_herpesvirus_8_strain_GK18_g_3 60779 4201_Human_herpesvirus_8_strain_GK18_g_4 60780 4201_Human_herpesvirus_8_strain_GK18_g_5 60781 4202_Human_herpesvirus_8_strain_GK18_g_1 60782 4202_Human_herpesvirus_8_strain_GK18_g_2 60783 4203_Human_herpesvirus_8_strain_GK18_g_1 60784 4203_Human_herpesvirus_8_strain_GK18_g_2 60785 4203_Human_herpesvirus_8_strain_GK18_g_3 60786 4203_Human_herpesvirus_8_strain_GK18_g_4 60787 4204_Human_papillomavirus_—_2_g_1 60788 4204_Human_papillomavirus_—_2_g_2 60789 4204_Human_papillomavirus_—_2_g_3 60790 4204_Human_papillomavirus_—_2_g_4 60791 4204_Human_papillomavirus_—_2_g_5 60792 4205_Human_papillomavirus_—_2_g_1 60793 4205_Human_papillomavirus_—_2_g_2 60794 4205_Human_papillomavirus_—_2_g_3 60795 4205_Human_papillomavirus_—_2_g_4 60796 4205_Human_papillomavirus_—_2_g_5 60797 4206_Human_papillomavirus_—_2_g_1 60798 4206_Human_papillomavirus_—_2_g_2 60799 4206_Human_papillomavirus_—_2_g_3 60800 4206_Human_papillomavirus_—_2_g_4 60801 4206_Human_papillomavirus_—_2_g_5 60802 4207_Human_papillomavirus_—_2_g_1 60803 4207_Human_papillomavirus_—_2_g_2 60804 4207_Human_papillomavirus_—_2_g_3 60805 4207_Human_papillomavirus_—_2_g_4 60806 4207_Human_papillomavirus_—_2_g_5 60807 4208_Human_papillomavirus_—_2_g_1 60808 4208_Human_papillomavirus_—_2_g_2 60809 4208_Human_papillomavirus_—_2_g_3 60810 4208_Human_papillomavirus_—_2_g_4 60811 4208_Human_papillomavirus_—_2_g_5 60812 4209_Human_papillomavirus_—_2_g_1 60813 4209_Human_papillomavirus_—_2_g_2 60814 4209_Human_papillomavirus_—_2_g_3 60815 4209_Human_papillomavirus_—_2_g_4 60816 4209_Human_papillomavirus_—_2_g_5 60817 4210_Human_papillomavirus_—_2_g_1 60818 4210_Human_papillomavirus_—_2_g_2 60819 4210_Human_papillomavirus_—_2_g_3 60820 4210_Human_papillomavirus_—_2_g_4 60821 4210_Human_papillomavirus_—_2_g_5 60822 4211_Human_papillomavirus_—_2_g_1 60823 4211_Human_papillomavirus_—_2_g_2 60824 4211_Human_papillomavirus_—_2_g_3 60825 4211_Human_papillomavirus_—_2_g_4 60826 4211_Human_papillomavirus_—_2_g_5 60827 4212_Human_papillomavirus_—_2_g_1 60828 4212_Human_papillomavirus_—_2_g_2 60829 4212_Human_papillomavirus_—_2_g_3 60830 4212_Human_papillomavirus_—_2_g_4 60831 4212_Human_papillomavirus_—_2_g_5 60832 4213_Human_papillomavirus_—_2_g_1 60833 4213_Human_papillomavirus_—_2_g_2 60834 4213_Human_papillomavirus_—_2_g_3 60835 4213_Human_papillomavirus_—_2_g_4 60836 4213_Human_papillomavirus_—_2_g_5 60837 4214_Human_papillomavirus_—_2_g_1 60838 4214_Human_papillomavirus_—_2_g_2 60839 4214_Human_papillomavirus_—_2_g_3 60840 4214_Human_papillomavirus_—_2_g_4 60841 4214_Human_papillomavirus_—_2_g_5 60842 4215_Human_papillomavirus_—_2_g_1 60843 4215_Human_papillomavirus_—_2_g_2 60844 4215_Human_papillomavirus_—_2_g_3 60845 4215_Human_papillomavirus_—_2_g_4 60846 4215_Human_papillomavirus_—_2_g_5 60847 4216_Human_papillomavirus_—_2_g_1 60848 4216_Human_papillomavirus_—_2_g_2 60849 4216_Human_papillomavirus_—_2_g_3 60850 4216_Human_papillomavirus_—_2_g_4 60851 4216_Human_papillomavirus_—_2_g_5 60852 4217_Human_papillomavirus_—_2_g_1 60853 4217_Human_papillomavirus_—_2_g_2 60854 4217_Human_papillomavirus_—_2_g_3 60855 4217_Human_papillomavirus_—_2_g_4 60856 4217_Human_papillomavirus_—_2_g_5 60857 4218_Human_papillomavirus_—_2_g_1 60858 4218_Human_papillomavirus_—_2_g_2 60859 4218_Human_papillomavirus_—_2_g_3 60860 4218_Human_papillomavirus_—_2_g_4 60861 4218_Human_papillomavirus_—_2_g_5 60862 4219_Human_papillomavirus_—_2_g_1 60863 4219_Human_papillomavirus_—_2_g_2 60864 4219_Human_papillomavirus_—_2_g_3 60865 4219_Human_papillomavirus_—_2_g_4 60866 4219_Human_papillomavirus_—_2_g_5 60867 4220_Human_papillomavirus_type_134_g_1 60868 4220_Human_papillomavirus_type_134_g_2 60869 4220_Human_papillomavirus_type_134_g_3 60870 4220_Human_papillomavirus_type_134_g_4 60871 4220_Human_papillomavirus_type_134_g_5 60872 4221_Human_papillomavirus_type_134_g_1 60873 4221_Human_papillomavirus_type_134_g_2 60874 4221_Human_papillomavirus_type_134_g_3 60875 4221_Human_papillomavirus_type_134_g_4 60876 4221_Human_papillomavirus_type_134_g_5 60877 4222_Human_papillomavirus_type_134_g_1 60878 4222_Human_papillomavirus_type_134_g_2 60879 4222_Human_papillomavirus_type_134_g_3 60880 4222_Human_papillomavirus_type_134_g_4 60881 4222_Human_papillomavirus_type_134_g_5 60882 4223_Human_papillomavirus_type_134_g_1 60883 4223_Human_papillomavirus_type_134_g_2 60884 4223_Human_papillomavirus_type_134_g_3 60885 4223_Human_papillomavirus_type_134_g_4 60886 4223_Human_papillomavirus_type_134_g_5 60887 4224_Human_papillomavirus_type_134_g_1 60888 4224_Human_papillomavirus_type_134_g_2 60889 4224_Human_papillomavirus_type_134_g_3 60890 4224_Human_papillomavirus_type_134_g_4 60891 4224_Human_papillomavirus_type_134_g_5 60892 4225_Human_papillomavirus_type_134_g_1 60893 4225_Human_papillomavirus_type_134_g_2 60894 4225_Human_papillomavirus_type_134_g_3 60895 4225_Human_papillomavirus_type_134_g_4 60896 4225_Human_papillomavirus_type_134_g_5 60897 4226_Human_papillomavirus_type_134_g_1 60898 4226_Human_papillomavirus_type_134_g_2 60899 4226_Human_papillomavirus_type_134_g_3 60900 4226_Human_papillomavirus_type_134_g_4 60901 4226_Human_papillomavirus_type_134_g_5 60902 4227_Human_papillomavirus_type_134_g_1 60903 4227_Human_papillomavirus_type_134_g_2 60904 4227_Human_papillomavirus_type_134_g_3 60905 4227_Human_papillomavirus_type_134_g_4 60906 4227_Human_papillomavirus_type_134_g_5 60907 4228_Human_papillomavirus_type_134_g_1 60908 4228_Human_papillomavirus_type_134_g_2 60909 4228_Human_papillomavirus_type_134_g_3 60910 4228_Human_papillomavirus_type_134_g_4 60911 4228_Human_papillomavirus_type_134_g_5 60912 4229_Human_papillomavirus_type_134_g_1 60913 4229_Human_papillomavirus_type_134_g_2 60914 4229_Human_papillomavirus_type_134_g_3 60915 4229_Human_papillomavirus_type_134_g_4 60916 4229_Human_papillomavirus_type_134_g_5 60917 4230_Human_papillomavirus_type_134_g_1 60918 4230_Human_papillomavirus_type_134_g_2 60919 4230_Human_papillomavirus_type_134_g_3 60920 4230_Human_papillomavirus_type_134_g_4 60921 4230_Human_papillomavirus_type_134_g_5 60922 4231_Human_papillomavirus_type_134_g_1 60923 4231_Human_papillomavirus_type_134_g_2 60924 4231_Human_papillomavirus_type_134_g_3 60925 4231_Human_papillomavirus_type_134_g_4 60926 4231_Human_papillomavirus_type_134_g_5 60927 4232_Human_papillomavirus_type_134_g_1 60928 4232_Human_papillomavirus_type_134_g_2 60929 4232_Human_papillomavirus_type_134_g_3 60930 4232_Human_papillomavirus_type_134_g_4 60931 4232_Human_papillomavirus_type_134_g_5 60932 4233_Human_papillomavirus_type_134_g_1 60933 4233_Human_papillomavirus_type_134_g_2 60934 4233_Human_papillomavirus_type_134_g_3 60935 4233_Human_papillomavirus_type_134_g_4 60936 4233_Human_papillomavirus_type_134_g_5 60937 4234_Human_papillomavirus_type_134_g_1 60938 4234_Human_papillomavirus_type_134_g_2 60939 4234_Human_papillomavirus_type_134_g_3 60940 4234_Human_papillomavirus_type_134_g_4 60941 4234_Human_papillomavirus_type_134_g_5 60942 4235_Human_papillomavirus_type_137_g_1 60943 4235_Human_papillomavirus_type_137_g_2 60944 4235_Human_papillomavirus_type_137_g_3 60945 4235_Human_papillomavirus_type_137_g_4 60946 4235_Human_papillomavirus_type_137_g_5 60947 4236_Human_papillomavirus_type_137_g_1 60948 4236_Human_papillomavirus_type_137_g_2 60949 4236_Human_papillomavirus_type_137_g_3 60950 4236_Human_papillomavirus_type_137_g_4 60951 4236_Human_papillomavirus_type_137_g_5 60952 4237_Human_papillomavirus_type_137_g_1 60953 4237_Human_papillomavirus_type_137_g_2 60954 4237_Human_papillomavirus_type_137_g_3 60955 4237_Human_papillomavirus_type_137_g_4 60956 4237_Human_papillomavirus_type_137_g_5 60957 4238_Human_papillomavirus_type_137_g_1 60958 4238_Human_papillomavirus_type_137_g_2 60959 4238_Human_papillomavirus_type_137_g_3 60960 4238_Human_papillomavirus_type_137_g_4 60961 4238_Human_papillomavirus_type_137_g_5 60962 4239_Human_papillomavirus_type_137_g_1 60963 4239_Human_papillomavirus_type_137_g_2 60964 4239_Human_papillomavirus_type_137_g_3 60965 4239_Human_papillomavirus_type_137_g_4 60966 4239_Human_papillomavirus_type_137_g_5 60967 4240_Human_papillomavirus_type_137_g_1 60968 4240_Human_papillomavirus_type_137_g_2 60969 4240_Human_papillomavirus_type_137_g_3 60970 4240_Human_papillomavirus_type_137_g_4 60971 4240_Human_papillomavirus_type_137_g_5 60972 4241_Human_papillomavirus_type_137_g_1 60973 4241_Human_papillomavirus_type_137_g_2 60974 4241_Human_papillomavirus_type_137_g_3 60975 4241_Human_papillomavirus_type_137_g_4 60976 4241_Human_papillomavirus_type_137_g_5 60977 4242_Human_papillomavirus_type_137_g_1 60978 4242_Human_papillomavirus_type_137_g_2 60979 4242_Human_papillomavirus_type_137_g_3 60980 4242_Human_papillomavirus_type_137_g_4 60981 4242_Human_papillomavirus_type_137_g_5 60982 4243_Human_papillomavirus_type_137_g_1 60983 4243_Human_papillomavirus_type_137_g_2 60984 4243_Human_papillomavirus_type_137_g_3 60985 4243_Human_papillomavirus_type_137_g_4 60986 4243_Human_papillomavirus_type_137_g_5 60987 4244_Human_papillomavirus_type_137_g_1 60988 4244_Human_papillomavirus_type_137_g_2 60989 4244_Human_papillomavirus_type_137_g_3 60990 4244_Human_papillomavirus_type_137_g_4 60991 4244_Human_papillomavirus_type_137_g_5 60992 4245_Human_papillomavirus_type_137_g_1 60993 4245_Human_papillomavirus_type_137_g_2 60994 4245_Human_papillomavirus_type_137_g_3 60995 4245_Human_papillomavirus_type_137_g_4 60996 4245_Human_papillomavirus_type_137_g_5 60997 4246_Human_papillomavirus_type_137_g_1 60998 4246_Human_papillomavirus_type_137_g_2 60999 4246_Human_papillomavirus_type_137_g_3 61000 4246_Human_papillomavirus_type_137_g_4 61001 4246_Human_papillomavirus_type_137_g_5 61002 4247_Human_papillomavirus_type_137_g_1 61003 4247_Human_papillomavirus_type_137_g_2 61004 4247_Human_papillomavirus_type_137_g_3 61005 4247_Human_papillomavirus_type_137_g_4 61006 4247_Human_papillomavirus_type_137_g_5 61007 4248_Human_papillomavirus_type_137_g_1 61008 4248_Human_papillomavirus_type_137_g_2 61009 4248_Human_papillomavirus_type_137_g_3 61010 4248_Human_papillomavirus_type_137_g_4 61011 4248_Human_papillomavirus_type_137_g_5 61012 4249_Human_papillomavirus_type_137_g_1 61013 4249_Human_papillomavirus_type_137_g_2 61014 4249_Human_papillomavirus_type_137_g_3 61015 4249_Human_papillomavirus_type_137_g_4 61016 4249_Human_papillomavirus_type_137_g_5 61017 4250_Influenza_B_virus_(B/Lee/1940)_segment_6_g_1 61018 4250_Influenza_B_virus_(B/Lee/1940)_segment_6_g_2 61019 4250_Influenza_B_virus_(B/Lee/1940)_segment_6_g_3 61020 4250_Influenza_B_virus_(B/Lee/1940)_segment_6_g_4 61021 4250_Influenza_B_virus_(B/Lee/1940)_segment_6_g_5 61022 4251_Influenza_B_virus_(B/Lee/1940)_segment_6_g_1 61023 4251_Influenza_B_virus_(B/Lee/1940)_segment_6_g_2 61024 4251_Influenza_B_virus_(B/Lee/1940)_segment_6_g_3 61025 4251_Influenza_B_virus_(B/Lee/1940)_segment_6_g_4 61026 4251_Influenza_B_virus_(B/Lee/1940)_segment_6_g_5 61027 4252_Influenza_B_virus_(B/Lee/1940)_segment_6_g_1 61028 4252_Influenza_B_virus_(B/Lee/1940)_segment_6_g_2 61029 4252_Influenza_B_virus_(B/Lee/1940)_segment_6_g_3 61030 4252_Influenza_B_virus_(B/Lee/1940)_segment_6_g_4 61031 4252_Influenza_B_virus_(B/Lee/1940)_segment_6_g_5 61032 4253_Influenza_B_virus_(B/Lee/1940)_segment_6_g_1 61033 4253_Influenza_B_virus_(B/Lee/1940)_segment_6_g_2 61034 4253_Influenza_B_virus_(B/Lee/1940)_segment_6_g_3 61035 4253_Influenza_B_virus_(B/Lee/1940)_segment_6_g_4 61036 4253_Influenza_B_virus_(B/Lee/1940)_segment_6_g_5 61037 4254_Influenza_B_virus_(B/Lee/1940)_segment_6_g_1 61038 4254_Influenza_B_virus_(B/Lee/1940)_segment_6_g_2 61039 4254_Influenza_B_virus_(B/Lee/1940)_segment_6_g_3 61040 4254_Influenza_B_virus_(B/Lee/1940)_segment_6_g_4 61041 4254_Influenza_B_virus_(B/Lee/1940)_segment_6_g_5 61042 4255_Influenza_B_virus_(B/Lee/1940)_segment_6_g_1 61043 4255_Influenza_B_virus_(B/Lee/1940)_segment_6_g_2 61044 4255_Influenza_B_virus_(B/Lee/1940)_segment_6_g_3 61045 4255_Influenza_B_virus_(B/Lee/1940)_segment_6_g_4 61046 4255_Influenza_B_virus_(B/Lee/1940)_segment_6_g_5 61047 4256_Human_papillomavirus_type_49_g_1 61048 4256_Human_papillomavirus_type_49_g_2 61049 4256_Human_papillomavirus_type_49_g_3 61050 4256_Human_papillomavirus_type_49_g_4 61051 4256_Human_papillomavirus_type_49_g_5 61052 4257_Human_papillomavirus_type_49_g_1 61053 4257_Human_papillomavirus_type_49_g_2 61054 4257_Human_papillomavirus_type_49_g_3 61055 4257_Human_papillomavirus_type_49_g_4 61056 4257_Human_papillomavirus_type_49_g_5 61057 4258_Human_papillomavirus_type_49_g_1 61058 4258_Human_papillomavirus_type_49_g_2 61059 4258_Human_papillomavirus_type_49_g_3 61060 4258_Human_papillomavirus_type_49_g_4 61061 4258_Human_papillomavirus_type_49_g_5 61062 4259_Human_papillomavirus_type_49_g_1 61063 4259_Human_papillomavirus_type_49_g_2 61064 4259_Human_papillomavirus_type_49_g_3 61065 4259_Human_papillomavirus_type_49_g_4 61066 4259_Human_papillomavirus_type_49_g_5 61067 4260_Human_papillomavirus_type_49_g_1 61068 4260_Human_papillomavirus_type_49_g_2 61069 4260_Human_papillomavirus_type_49_g_3 61070 4260_Human_papillomavirus_type_49_g_4 61071 4260_Human_papillomavirus_type_49_g_5 61072 4261_Human_papillomavirus_type_49_g_1 61073 4261_Human_papillomavirus_type_49_g_2 61074 4261_Human_papillomavirus_type_49_g_3 61075 4261_Human_papillomavirus_type_49_g_4 61076 4261_Human_papillomavirus_type_49_g_5 61077 4262_Human_papillomavirus_type_49_g_1 61078 4262_Human_papillomavirus_type_49_g_2 61079 4262_Human_papillomavirus_type_49_g_3 61080 4262_Human_papillomavirus_type_49_g_4 61081 4262_Human_papillomavirus_type_49_g_5 61082 4263_Human_papillomavirus_type_49_g_1 61083 4263_Human_papillomavirus_type_49_g_2 61084 4263_Human_papillomavirus_type_49_g_3 61085 4263_Human_papillomavirus_type_49_g_4 61086 4263_Human_papillomavirus_type_49_g_5 61087 4264_Human_papillomavirus_type_49_g_1 61088 4264_Human_papillomavirus_type_49_g_2 61089 4265_Human_papillomavirus_type_49_g_1 61090 4265_Human_papillomavirus_type_49_g_2 61091 4265_Human_papillomavirus_type_49_g_3 61092 4265_Human_papillomavirus_type_49_g_4 61093 4265_Human_papillomavirus_type_49_g_5 61094 4266_Human_papillomavirus_type_49_g_1 61095 4266_Human_papillomavirus_type_49_g_2 61096 4266_Human_papillomavirus_type_49_g_3 61097 4266_Human_papillomavirus_type_49_g_4 61098 4266_Human_papillomavirus_type_49_g_5 61099 4267_Human_papillomavirus_type_49_g_1 61100 4267_Human_papillomavirus_type_49_g_2 61101 4267_Human_papillomavirus_type_49_g_3 61102 4267_Human_papillomavirus_type_49_g_4 61103 4267_Human_papillomavirus_type_49_g_5 61104 4268_Human_papillomavirus_type_49_g_1 61105 4268_Human_papillomavirus_type_49_g_2 61106 4268_Human_papillomavirus_type_49_g_3 61107 4268_Human_papillomavirus_type_49_g_4 61108 4268_Human_papillomavirus_type_49_g_5 61109 4269_Human_papillomavirus_type_49_g_1 61110 4269_Human_papillomavirus_type_49_g_2 61111 4269_Human_papillomavirus_type_49_g_3 61112 4269_Human_papillomavirus_type_49_g_4 61113 4269_Human_papillomavirus_type_49_g_5 61114 4270_Human_papillomavirus_type_49_g_1 61115 4270_Human_papillomavirus_type_49_g_2 61116 4270_Human_papillomavirus_type_49_g_3 61117 4270_Human_papillomavirus_type_49_g_4 61118 4270_Human_papillomavirus_type_49_g_5 61119 4271_Human_papillomavirus_type_49_g_1 61120 4271_Human_papillomavirus_type_49_g_2 61121 4271_Human_papillomavirus_type_49_g_3 61122 4271_Human_papillomavirus_type_49_g_4 61123 4271_Human_papillomavirus_type_49_g_5 61124 4272_Human_papillomavirus_type_49_g_1 61125 4272_Human_papillomavirus_type_49_g_2 61126 4272_Human_papillomavirus_type_49_g_3 61127 4272_Human_papillomavirus_type_49_g_4 61128 4272_Human_papillomavirus_type_49_g_5 61129 4273_Human_papillomavirus_type_49_g_1 61130 4273_Human_papillomavirus_type_49_g_2 61131 4273_Human_papillomavirus_type_49_g_3 61132 4273_Human_papillomavirus_type_49_g_4 61133 4273_Human_papillomavirus_type_49_g_5 61134 4274_Human_papillomavirus_type_49_g_1 61135 4274_Human_papillomavirus_type_49_g_2 61136 4274_Human_papillomavirus_type_49_g_3 61137 4274_Human_papillomavirus_type_49_g_4 61138 4274_Human_papillomavirus_type_49_g_5 61139 4275_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 61140 8_nuclear_export_protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_1 4275_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 61141 8_nuclear_export_protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_2 4275_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 61142 8_nuclear_export_protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_3 4275_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 61143 8_nuclear_export_protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_4 4275_Influenza_A_virus_(A/Shanghai/02/2013(H7N9))_segment_(—) 61144 8_nuclear_export_protein_(NEP)_and_nonstructural_protein_1_(NS1)_genes_g_5 4276_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61145 for_polymerase_3_g_1 4276_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61146 for_polymerase_3_g_2 4276_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61147 for_polymerase_3_g_3 4276_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61148 for_polymerase_3_g_4 4276_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61149 for_polymerase_3_g_5 4277_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61150 for_polymerase_3_g_1 4277_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61151 for_polymerase_3_g_2 4277_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61152 for_polymerase_3_g_3 4277_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61153 for_polymerase_3_g_4 4277_Influenza_C_virus_(C/Ann_Arbor/1/50)_P3_gene_(—) 61154 for_polymerase_3_g_5 4278_Human_papillomavirus_type_126_g_1 61155 4278_Human_papillomavirus_type_126_g_2 61156 4278_Human_papillomavirus_type_126_g_3 61157 4278_Human_papillomavirus_type_126_g_4 61158 4278_Human_papillomavirus_type_126_g_5 61159 4279_Human_papillomavirus_type_126_g_1 61160 4279_Human_papillomavirus_type_126_g_2 61161 4279_Human_papillomavirus_type_126_g_3 61162 4279_Human_papillomavirus_type_126_g_4 61163 4279_Human_papillomavirus_type_126_g_5 61164 4280_Human_papillomavirus_type_126_g_1 61165 4280_Human_papillomavirus_type_126_g_2 61166 4280_Human_papillomavirus_type_126_g_3 61167 4280_Human_papillomavirus_type_126_g_4 61168 4280_Human_papillomavirus_type_126_g_5 61169 4281_Human_papillomavirus_type_126_g_1 61170 4281_Human_papillomavirus_type_126_g_2 61171 4281_Human_papillomavirus_type_126_g_3 61172 4281_Human_papillomavirus_type_126_g_4 61173 4281_Human_papillomavirus_type_126_g_5 61174 4282_Human_papillomavirus_type_126_g_1 61175 4282_Human_papillomavirus_type_126_g_2 61176 4282_Human_papillomavirus_type_126_g_3 61177 4282_Human_papillomavirus_type_126_g_4 61178 4283_Human_papillomavirus_type_126_g_1 61179 4283_Human_papillomavirus_type_126_g_2 61180 4283_Human_papillomavirus_type_126_g_3 61181 4283_Human_papillomavirus_type_126_g_4 61182 4283_Human_papillomavirus_type_126_g_5 61183 4284_Human_papillomavirus_type_126_g_1 61184 4284_Human_papillomavirus_type_126_g_2 61185 4284_Human_papillomavirus_type_126_g_3 61186 4284_Human_papillomavirus_type_126_g_4 61187 4284_Human_papillomavirus_type_126_g_5 61188 4285_Human_papillomavirus_type_126_g_1 61189 4285_Human_papillomavirus_type_126_g_2 61190 4285_Human_papillomavirus_type_126_g_3 61191 4285_Human_papillomavirus_type_126_g_4 61192 4285_Human_papillomavirus_type_126_g_5 61193 4286_Human_papillomavirus_type_126_g_1 61194 4286_Human_papillomavirus_type_126_g_2 61195 4286_Human_papillomavirus_type_126_g_3 61196 4286_Human_papillomavirus_type_126_g_4 61197 4286_Human_papillomavirus_type_126_g_5 61198 4287_Human_papillomavirus_type_126_g_1 61199 4287_Human_papillomavirus_type_126_g_2 61200 4287_Human_papillomavirus_type_126_g_3 61201 4287_Human_papillomavirus_type_126_g_4 61202 4287_Human_papillomavirus_type_126_g_5 61203 4288_Human_papillomavirus_type_128_g_1 61204 4288_Human_papillomavirus_type_128_g_2 61205 4288_Human_papillomavirus_type_128_g_3 61206 4288_Human_papillomavirus_type_128_g_4 61207 4288_Human_papillomavirus_type_128_g_5 61208 4289_Human_papillomavirus_type_128_g_1 61209 4289_Human_papillomavirus_type_128_g_2 61210 4289_Human_papillomavirus_type_128_g_3 61211 4289_Human_papillomavirus_type_128_g_4 61212 4289_Human_papillomavirus_type_128_g_5 61213 4290_Human_papillomavirus_type_128_g_1 61214 4290_Human_papillomavirus_type_128_g_2 61215 4290_Human_papillomavirus_type_128_g_3 61216 4290_Human_papillomavirus_type_128_g_4 61217 4290_Human_papillomavirus_type_128_g_5 61218 4291_Human_papillomavirus_type_128_g_1 61219 4291_Human_papillomavirus_type_128_g_2 61220 4291_Human_papillomavirus_type_128_g_3 61221 4291_Human_papillomavirus_type_128_g_4 61222 4291_Human_papillomavirus_type_128_g_5 61223 4292_Human_papillomavirus_type_128_g_1 61224 4292_Human_papillomavirus_type_128_g_2 61225 4292_Human_papillomavirus_type_128_g_3 61226 4292_Human_papillomavirus_type_128_g_4 61227 4292_Human_papillomavirus_type_128_g_5 61228 4293_Human_papillomavirus_type_128_g_1 61229 4293_Human_papillomavirus_type_128_g_2 61230 4293_Human_papillomavirus_type_128_g_3 61231 4293_Human_papillomavirus_type_128_g_4 61232 4293_Human_papillomavirus_type_128_g_5 61233 4294_Human_papillomavirus_type_128_g_1 61234 4294_Human_papillomavirus_type_128_g_2 61235 4294_Human_papillomavirus_type_128_g_3 61236 4294_Human_papillomavirus_type_128_g_4 61237 4294_Human_papillomavirus_type_128_g_5 61238 4295_Human_papillomavirus_type_128_g_1 61239 4295_Human_papillomavirus_type_128_g_2 61240 4295_Human_papillomavirus_type_128_g_3 61241 4295_Human_papillomavirus_type_128_g_4 61242 4295_Human_papillomavirus_type_128_g_5 61243 4296_Human_papillomavirus_type_128_g_1 61244 4296_Human_papillomavirus_type_128_g_2 61245 4296_Human_papillomavirus_type_128_g_3 61246 4296_Human_papillomavirus_type_128_g_4 61247 4296_Human_papillomavirus_type_128_g_5 61248 4297_Human_papillomavirus_type_128_g_1 61249 4297_Human_papillomavirus_type_128_g_2 61250 4297_Human_papillomavirus_type_128_g_3 61251 4297_Human_papillomavirus_type_128_g_4 61252 4297_Human_papillomavirus_type_128_g_5 61253 4298_Human_papillomavirus_type_128_g_1 61254 4298_Human_papillomavirus_type_128_g_2 61255 4298_Human_papillomavirus_type_128_g_3 61256 4298_Human_papillomavirus_type_128_g_4 61257 4298_Human_papillomavirus_type_128_g_5 61258 4299_Human_papillomavirus_type_128_g_1 61259 4299_Human_papillomavirus_type_128_g_2 61260 4299_Human_papillomavirus_type_128_g_3 61261 4299_Human_papillomavirus_type_128_g_4 61262 4299_Human_papillomavirus_type_128_g_5 61263 4300_Human_papillomavirus_type_128_g_1 61264 4300_Human_papillomavirus_type_128_g_2 61265 4300_Human_papillomavirus_type_128_g_3 61266 4300_Human_papillomavirus_type_128_g_4 61267 4300_Human_papillomavirus_type_128_g_5 61268 4301_Human_papillomavirus_type_144_g_1 61269 4301_Human_papillomavirus_type_144_g_2 61270 4301_Human_papillomavirus_type_144_g_3 61271 4301_Human_papillomavirus_type_144_g_4 61272 4301_Human_papillomavirus_type_144_g_5 61273 4302_Human_papillomavirus_type_144_g_1 61274 4302_Human_papillomavirus_type_144_g_2 61275 4302_Human_papillomavirus_type_144_g_3 61276 4302_Human_papillomavirus_type_144_g_4 61277 4302_Human_papillomavirus_type_144_g_5 61278 4303_Human_papillomavirus_type_144_g_1 61279 4303_Human_papillomavirus_type_144_g_2 61280 4303_Human_papillomavirus_type_144_g_3 61281 4303_Human_papillomavirus_type_144_g_4 61282 4303_Human_papillomavirus_type_144_g_5 61283 4304_Human_papillomavirus_type_144_g_1 61284 4304_Human_papillomavirus_type_144_g_2 61285 4304_Human_papillomavirus_type_144_g_3 61286 4304_Human_papillomavirus_type_144_g_4 61287 4304_Human_papillomavirus_type_144_g_5 61288 4305_Human_papillomavirus_type_144_g_1 61289 4305_Human_papillomavirus_type_144_g_2 61290 4305_Human_papillomavirus_type_144_g_3 61291 4305_Human_papillomavirus_type_144_g_4 61292 4305_Human_papillomavirus_type_144_g_5 61293 4306_Human_papillomavirus_type_144_g_1 61294 4306_Human_papillomavirus_type_144_g_2 61295 4306_Human_papillomavirus_type_144_g_3 61296 4306_Human_papillomavirus_type_144_g_4 61297 4306_Human_papillomavirus_type_144_g_5 61298 4307_Human_papillomavirus_type_144_g_1 61299 4307_Human_papillomavirus_type_144_g_2 61300 4307_Human_papillomavirus_type_144_g_3 61301 4307_Human_papillomavirus_type_144_g_4 61302 4307_Human_papillomavirus_type_144_g_5 61303 4308_Human_papillomavirus_type_144_g_1 61304 4308_Human_papillomavirus_type_144_g_2 61305 4308_Human_papillomavirus_type_144_g_3 61306 4308_Human_papillomavirus_type_144_g_4 61307 4308_Human_papillomavirus_type_144_g_5 61308 4309_Human_papillomavirus_type_144_g_1 61309 4309_Human_papillomavirus_type_144_g_2 61310 4309_Human_papillomavirus_type_144_g_3 61311 4309_Human_papillomavirus_type_144_g_4 61312 4309_Human_papillomavirus_type_144_g_5 61313 4310_Human_papillomavirus_type_144_g_1 61314 4310_Human_papillomavirus_type_144_g_2 61315 4310_Human_papillomavirus_type_144_g_3 61316 4310_Human_papillomavirus_type_144_g_4 61317 4310_Human_papillomavirus_type_144_g_5 61318 4311_Human_papillomavirus_type_144_g_1 61319 4311_Human_papillomavirus_type_144_g_2 61320 4311_Human_papillomavirus_type_144_g_3 61321 4311_Human_papillomavirus_type_144_g_4 61322 4311_Human_papillomavirus_type_144_g_5 61323 4312_Human_papillomavirus_type_144_g_1 61324 4312_Human_papillomavirus_type_144_g_2 61325 4312_Human_papillomavirus_type_144_g_3 61326 4312_Human_papillomavirus_type_144_g_4 61327 4312_Human_papillomavirus_type_144_g_5 61328 4313_Human_papillomavirus_type_144_g_1 61329 4313_Human_papillomavirus_type_144_g_2 61330 4313_Human_papillomavirus_type_144_g_3 61331 4313_Human_papillomavirus_type_144_g_4 61332 4313_Human_papillomavirus_type_144_g_5 61333 4314_Human_papillomavirus_type_144_g_1 61334 4314_Human_papillomavirus_type_144_g_2 61335 4314_Human_papillomavirus_type_144_g_3 61336 4314_Human_papillomavirus_type_144_g_4 61337 4314_Human_papillomavirus_type_144_g_5 61338 4315_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61339 segment_5_g_1 4315_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61340 segment_5_g_2 4315_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61341 segment_5_g_3 4315_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61342 segment_5_g_4 4315_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61343 segment_5_g_5 4316_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61344 segment_5_g_1 4316_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61345 segment_5_g_2 4316_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61346 segment_5_g_3 4316_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61347 segment_5_g_4 4316_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61348 segment_5_g_5 4317_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61349 segment_5_g_1 4317_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61350 segment_5_g_2 4317_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61351 segment_5_g_3 4317_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61352 segment_5_g_4 4317_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61353 segment_5_g_5 4318_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61354 segment_5_g_1 4318_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61355 segment_5_g_2 4318_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61356 segment_5_g_3 4318_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61357 segment_5_g_4 4318_Influenza_A_virus_(A/New_York/392/2004(H3N2))_(—) 61358 segment_5_g_5 4319_Human_papillomavirus_type_30_genomic_DNA_g_1 61359 4319_Human_papillomavirus_type_30_genomic_DNA_g_2 61360 4319_Human_papillomavirus_type_30_genomic_DNA_g_3 61361 4319_Human_papillomavirus_type_30_genomic_DNA_g_4 61362 4319_Human_papillomavirus_type_30_genomic_DNA_g_5 61363 4320_Human_papillomavirus_type_30_genomic_DNA_g_1 61364 4320_Human_papillomavirus_type_30_genomic_DNA_g_2 61365 4320_Human_papillomavirus_type_30_genomic_DNA_g_3 61366 4320_Human_papillomavirus_type_30_genomic_DNA_g_4 61367 4320_Human_papillomavirus_type_30_genomic_DNA_g_5 61368 4321_Human_papillomavirus_type_30_genomic_DNA_g_1 61369 4321_Human_papillomavirus_type_30_genomic_DNA_g_2 61370 4321_Human_papillomavirus_type_30_genomic_DNA_g_3 61371 4321_Human_papillomavirus_type_30_genomic_DNA_g_4 61372 4321_Human_papillomavirus_type_30_genomic_DNA_g_5 61373 4322_Human_papillomavirus_type_30_genomic_DNA_g_1 61374 4322_Human_papillomavirus_type_30_genomic_DNA_g_2 61375 4322_Human_papillomavirus_type_30_genomic_DNA_g_3 61376 4322_Human_papillomavirus_type_30_genomic_DNA_g_4 61377 4322_Human_papillomavirus_type_30_genomic_DNA_g_5 61378 4323_Human_papillomavirus_type_30_genomic_DNA_g_1 61379 4323_Human_papillomavirus_type_30_genomic_DNA_g_2 61380 4323_Human_papillomavirus_type_30_genomic_DNA_g_3 61381 4323_Human_papillomavirus_type_30_genomic_DNA_g_4 61382 4323_Human_papillomavirus_type_30_genomic_DNA_g_5 61383 4324_Human_papillomavirus_type_30_genomic_DNA_g_1 61384 4324_Human_papillomavirus_type_30_genomic_DNA_g_2 61385 4324_Human_papillomavirus_type_30_genomic_DNA_g_3 61386 4324_Human_papillomavirus_type_30_genomic_DNA_g_4 61387 4324_Human_papillomavirus_type_30_genomic_DNA_g_5 61388 4325_Human_papillomavirus_type_30_genomic_DNA_g_1 61389 4325_Human_papillomavirus_type_30_genomic_DNA_g_2 61390 4325_Human_papillomavirus_type_30_genomic_DNA_g_3 61391 4325_Human_papillomavirus_type_30_genomic_DNA_g_4 61392 4325_Human_papillomavirus_type_30_genomic_DNA_g_5 61393 4326_Human_papillomavirus_type_30_genomic_DNA_g_1 61394 4326_Human_papillomavirus_type_30_genomic_DNA_g_2 61395 4326_Human_papillomavirus_type_30_genomic_DNA_g_3 61396 4326_Human_papillomavirus_type_30_genomic_DNA_g_4 61397 4326_Human_papillomavirus_type_30_genomic_DNA_g_5 61398 4327_Human_papillomavirus_type_30_genomic_DNA_g_1 61399 4327_Human_papillomavirus_type_30_genomic_DNA_g_2 61400 4327_Human_papillomavirus_type_30_genomic_DNA_g_3 61401 4327_Human_papillomavirus_type_30_genomic_DNA_g_4 61402 4327_Human_papillomavirus_type_30_genomic_DNA_g_5 61403 4328_Human_papillomavirus_type_30_genomic_DNA_g_1 61404 4328_Human_papillomavirus_type_30_genomic_DNA_g_2 61405 4328_Human_papillomavirus_type_30_genomic_DNA_g_3 61406 4328_Human_papillomavirus_type_30_genomic_DNA_g_4 61407 4328_Human_papillomavirus_type_30_genomic_DNA_g_5 61408 4329_Human_papillomavirus_type_30_genomic_DNA_g_1 61409 4329_Human_papillomavirus_type_30_genomic_DNA_g_2 61410 4329_Human_papillomavirus_type_30_genomic_DNA_g_3 61411 4329_Human_papillomavirus_type_30_genomic_DNA_g_4 61412 4329_Human_papillomavirus_type_30_genomic_DNA_g_5 61413 4330_Human_papillomavirus_type_30_genomic_DNA_g_1 61414 4330_Human_papillomavirus_type_30_genomic_DNA_g_2 61415 4330_Human_papillomavirus_type_30_genomic_DNA_g_3 61416 4330_Human_papillomavirus_type_30_genomic_DNA_g_4 61417 4330_Human_papillomavirus_type_30_genomic_DNA_g_5 61418 4331_Human_papillomavirus_type_30_genomic_DNA_g_1 61419 4331_Human_papillomavirus_type_30_genomic_DNA_g_2 61420 4331_Human_papillomavirus_type_30_genomic_DNA_g_3 61421 4331_Human_papillomavirus_type_30_genomic_DNA_g_4 61422 4331_Human_papillomavirus_type_30_genomic_DNA_g_5 61423 4332_Human_papillomavirus_type_30_genomic_DNA_g_1 61424 4332_Human_papillomavirus_type_30_genomic_DNA_g_2 61425 4332_Human_papillomavirus_type_30_genomic_DNA_g_3 61426 4332_Human_papillomavirus_type_30_genomic_DNA_g_4 61427 4332_Human_papillomavirus_type_30_genomic_DNA_g_5 61428 4333_Human_papillomavirus_type_30_genomic_DNA_g_1 61429 4333_Human_papillomavirus_type_30_genomic_DNA_g_2 61430 4333_Human_papillomavirus_type_30_genomic_DNA_g_3 61431 4333_Human_papillomavirus_type_30_genomic_DNA_g_4 61432 4333_Human_papillomavirus_type_30_genomic_DNA_g_5 61433 4334_Human_papillomavirus_type_30_genomic_DNA_g_1 61434 4334_Human_papillomavirus_type_30_genomic_DNA_g_2 61435 4334_Human_papillomavirus_type_30_genomic_DNA_g_3 61436 4334_Human_papillomavirus_type_30_genomic_DNA_g_4 61437 4334_Human_papillomavirus_type_30_genomic_DNA_g_5 61438 4335_Human_papillomavirus_type_30_genomic_DNA_g_1 61439 4335_Human_papillomavirus_type_30_genomic_DNA_g_2 61440 4335_Human_papillomavirus_type_30_genomic_DNA_g_3 61441 4335_Human_papillomavirus_type_30_genomic_DNA_g_4 61442 4335_Human_papillomavirus_type_30_genomic_DNA_g_5 61443 4336_Human_papillomavirus_type_30_genomic_DNA_g_1 61444 4336_Human_papillomavirus_type_30_genomic_DNA_g_2 61445 4336_Human_papillomavirus_type_30_genomic_DNA_g_3 61446 4336_Human_papillomavirus_type_30_genomic_DNA_g_4 61447 4336_Human_papillomavirus_type_30_genomic_DNA_g_5 61448 4337_Human_papillomavirus_type_34_g_1 61449 4337_Human_papillomavirus_type_34_g_2 61450 4337_Human_papillomavirus_type_34_g_3 61451 4337_Human_papillomavirus_type_34_g_4 61452 4337_Human_papillomavirus_type_34_g_5 61453 4338_Human_papillomavirus_type_34_g_1 61454 4338_Human_papillomavirus_type_34_g_2 61455 4338_Human_papillomavirus_type_34_g_3 61456 4338_Human_papillomavirus_type_34_g_4 61457 4338_Human_papillomavirus_type_34_g_5 61458 4339_Human_papillomavirus_type_34_g_1 61459 4339_Human_papillomavirus_type_34_g_2 61460 4339_Human_papillomavirus_type_34_g_3 61461 4339_Human_papillomavirus_type_34_g_4 61462 4339_Human_papillomavirus_type_34_g_5 61463 4340_Human_papillomavirus_type_34_g_1 61464 4340_Human_papillomavirus_type_34_g_2 61465 4340_Human_papillomavirus_type_34_g_3 61466 4340_Human_papillomavirus_type_34_g_4 61467 4340_Human_papillomavirus_type_34_g_5 61468 4341_Human_papillomavirus_type_34_g_1 61469 4341_Human_papillomavirus_type_34_g_2 61470 4341_Human_papillomavirus_type_34_g_3 61471 4341_Human_papillomavirus_type_34_g_4 61472 4341_Human_papillomavirus_type_34_g_5 61473 4342_Human_papillomavirus_type_34_g_1 61474 4342_Human_papillomavirus_type_34_g_2 61475 4342_Human_papillomavirus_type_34_g_3 61476 4342_Human_papillomavirus_type_34_g_4 61477 4342_Human_papillomavirus_type_34_g_5 61478 4343_Human_papillomavirus_type_34_g_1 61479 4343_Human_papillomavirus_type_34_g_2 61480 4343_Human_papillomavirus_type_34_g_3 61481 4343_Human_papillomavirus_type_34_g_4 61482 4343_Human_papillomavirus_type_34_g_5 61483 4344_Human_papillomavirus_type_34_g_1 61484 4344_Human_papillomavirus_type_34_g_2 61485 4344_Human_papillomavirus_type_34_g_3 61486 4344_Human_papillomavirus_type_34_g_4 61487 4344_Human_papillomavirus_type_34_g_5 61488 4345_Human_papillomavirus_type_34_g_1 61489 4345_Human_papillomavirus_type_34_g_2 61490 4345_Human_papillomavirus_type_34_g_3 61491 4345_Human_papillomavirus_type_34_g_4 61492 4345_Human_papillomavirus_type_34_g_5 61493 4346_Human_papillomavirus_type_34_g_1 61494 4346_Human_papillomavirus_type_34_g_2 61495 4346_Human_papillomavirus_type_34_g_3 61496 4346_Human_papillomavirus_type_34_g_4 61497 4346_Human_papillomavirus_type_34_g_5 61498 4347_Human_papillomavirus_type_34_g_1 61499 4347_Human_papillomavirus_type_34_g_2 61500 4347_Human_papillomavirus_type_34_g_3 61501 4347_Human_papillomavirus_type_34_g_4 61502 4347_Human_papillomavirus_type_34_g_5 61503 4348_Human_papillomavirus_type_34_g_1 61504 4348_Human_papillomavirus_type_34_g_2 61505 4348_Human_papillomavirus_type_34_g_3 61506 4348_Human_papillomavirus_type_34_g_4 61507 4348_Human_papillomavirus_type_34_g_5 61508 4349_Human_papillomavirus_type_34_g_1 61509 4349_Human_papillomavirus_type_34_g_2 61510 4349_Human_papillomavirus_type_34_g_3 61511 4349_Human_papillomavirus_type_34_g_4 61512 4349_Human_papillomavirus_type_34_g_5 61513 4350_Human_papillomavirus_type_34_g_1 61514 4350_Human_papillomavirus_type_34_g_2 61515 4350_Human_papillomavirus_type_34_g_3 61516 4350_Human_papillomavirus_type_34_g_4 61517 4350_Human_papillomavirus_type_34_g_5 61518 4351_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61519 hemagglutinin_(HA)_gene_g_1 4351_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61520 hemagglutinin_(HA)_gene_g_2 4351_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61521 hemagglutinin_(HA)_gene_g_3 4351_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61522 hemagglutinin_(HA)_gene_g_4 4351_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61523 hemagglutinin_(HA)_gene_g_5 4352_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61524 hemagglutinin_(HA)_gene_g_1 4352_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61525 hemagglutinin_(HA)_gene_g_2 4352_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61526 hemagglutinin_(HA)_gene_g_3 4352_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61527 hemagglutinin_(HA)_gene_g_4 4352_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61528 hemagglutinin_(HA)_gene_g_5 4353_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61529 hemagglutinin_(HA)_gene_g_1 4353_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61530 hemagglutinin_(HA)_gene_g_2 4353_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61531 hemagglutinin_(HA)_gene_g_3 4353_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61532 hemagglutinin_(HA)_gene_g_4 4353_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61533 hemagglutinin_(HA)_gene_g_5 4354_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61534 hemagglutinin_(HA)_gene_g_1 4354_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61535 hemagglutinin_(HA)_gene_g_2 4354_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61536 hemagglutinin_(HA)_gene_g_3 4354_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61537 hemagglutinin_(HA)_gene_g_4 4354_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61538 hemagglutinin_(HA)_gene_g_5 4355_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61539 hemagglutinin_(HA)_gene_g_1 4355_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61540 hemagglutinin_(HA)_gene_g_2 4355_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61541 hemagglutinin_(HA)_gene_g_3 4355_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61542 hemagglutinin_(HA)_gene_g_4 4355_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61543 hemagglutinin_(HA)_gene_g_5 4356_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61544 hemagglutinin_(HA)_gene_g_1 4356_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61545 hemagglutinin_(HA)_gene_g_2 4356_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61546 hemagglutinin_(HA)_gene_g_3 4356_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61547 hemagglutinin_(HA)_gene_g_4 4356_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61548 hemagglutinin_(HA)_gene_g_5 4357_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61549 hemagglutinin_(HA)_gene_g_1 4357_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61550 hemagglutinin_(HA)_gene_g_2 4357_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61551 hemagglutinin_(HA)_gene_g_3 4357_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61552 hemagglutinin_(HA)_gene_g_4 4357_Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1))_(—) 61553 hemagglutinin_(HA)_gene_g_5 4358_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61554 segment_5_g_1 4358_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61555 segment_5_g_2 4358_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61556 segment_5_g_3 4358_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61557 segment_5_g_4 4358_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61558 segment_5_g_5 4359_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61559 segment_5_g_1 4359_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61560 segment_5_g_2 4359_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61561 segment_5_g_3 4359_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61562 segment_5_g_4 4359_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61563 segment_5_g_5 4360_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61564 segment_5_g_1 4360_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61565 segment_5_g_2 4360_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61566 segment_5_g_3 4360_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61567 segment_5_g_4 4360_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61568 segment_5_g_5 4361_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61569 segment_5_g_1 4361_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61570 segment_5_g_2 4361_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61571 segment_5_g_3 4361_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61572 segment_5_g_4 4361_Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1))_(—) 61573 segment_5_g_5 4362_Human_papillomavirus_type_101_g_1 61574 4362_Human_papillomavirus_type_101_g_2 61575 4362_Human_papillomavirus_type_101_g_3 61576 4362_Human_papillomavirus_type_101_g_4 61577 4362_Human_papillomavirus_type_101_g_5 61578 4363_Human_papillomavirus_type_101_g_1 61579 4363_Human_papillomavirus_type_101_g_2 61580 4363_Human_papillomavirus_type_101_g_3 61581 4363_Human_papillomavirus_type_101_g_4 61582 4363_Human_papillomavirus_type_101_g_5 61583 4364_Human_papillomavirus_type_101_g_1 61584 4364_Human_papillomavirus_type_101_g_2 61585 4364_Human_papillomavirus_type_101_g_3 61586 4364_Human_papillomavirus_type_101_g_4 61587 4364_Human_papillomavirus_type_101_g_5 61588 4365_Human_papillomavirus_type_101_g_1 61589 4365_Human_papillomavirus_type_101_g_2 61590 4365_Human_papillomavirus_type_101_g_3 61591 4365_Human_papillomavirus_type_101_g_4 61592 4365_Human_papillomavirus_type_101_g_5 61593 4366_Human_papillomavirus_type_101_g_1 61594 4366_Human_papillomavirus_type_101_g_2 61595 4366_Human_papillomavirus_type_101_g_3 61596 4366_Human_papillomavirus_type_101_g_4 61597 4366_Human_papillomavirus_type_101_g_5 61598 4367_Human_papillomavirus_type_101_g_1 61599 4367_Human_papillomavirus_type_101_g_2 61600 4367_Human_papillomavirus_type_101_g_3 61601 4367_Human_papillomavirus_type_101_g_4 61602 4367_Human_papillomavirus_type_101_g_5 61603 4368_Human_papillomavirus_type_101_g_1 61604 4368_Human_papillomavirus_type_101_g_2 61605 4368_Human_papillomavirus_type_101_g_3 61606 4368_Human_papillomavirus_type_101_g_4 61607 4368_Human_papillomavirus_type_101_g_5 61608 4369_Human_papillomavirus_type_101_g_1 61609 4369_Human_papillomavirus_type_101_g_2 61610 4369_Human_papillomavirus_type_101_g_3 61611 4369_Human_papillomavirus_type_101_g_4 61612 4369_Human_papillomavirus_type_101_g_5 61613 4370_Human_papillomavirus_type_101_g_1 61614 4370_Human_papillomavirus_type_101_g_2 61615 4370_Human_papillomavirus_type_101_g_3 61616 4370_Human_papillomavirus_type_101_g_4 61617 4370_Human_papillomavirus_type_101_g_5 61618 4371_Human_papillomavirus_type_101_g_1 61619 4371_Human_papillomavirus_type_101_g_2 61620 4371_Human_papillomavirus_type_101_g_3 61621 4371_Human_papillomavirus_type_101_g_4 61622 4371_Human_papillomavirus_type_101_g_5 61623 4372_Human_papillomavirus_type_101_g_1 61624 4372_Human_papillomavirus_type_101_g_2 61625 4372_Human_papillomavirus_type_101_g_3 61626 4372_Human_papillomavirus_type_101_g_4 61627 4372_Human_papillomavirus_type_101_g_5 61628 4373_Human_papillomavirus_type_101_g_1 61629 4373_Human_papillomavirus_type_101_g_2 61630 4373_Human_papillomavirus_type_101_g_3 61631 4373_Human_papillomavirus_type_101_g_4 61632 4373_Human_papillomavirus_type_101_g_5 61633 4374_Human_papillomavirus_type_101_g_1 61634 4374_Human_papillomavirus_type_101_g_2 61635 4374_Human_papillomavirus_type_101_g_3 61636 4374_Human_papillomavirus_type_101_g_4 61637 4374_Human_papillomavirus_type_101_g_5 61638 4375_Human_papillomavirus_type_101_g_1 61639 4375_Human_papillomavirus_type_101_g_2 61640 4375_Human_papillomavirus_type_101_g_3 61641 4375_Human_papillomavirus_type_101_g_4 61642 4375_Human_papillomavirus_type_101_g_5 61643

Thermostable Proteins

In certain example embodiments, the protein selected may be more thermostable at higher temperatures. Exemplary proteins may comprise any Cas protein with collateral effect when used with particular methodologies disclosed herein. In an aspect, the Cas protein is a thermostable protein. The thermostable Cas protein may be a Type V or a Type VI protein, for example, a Cas12 or Cas13 protein. In embodiments, the thermostable protein, upon activation, comprises collateral cleavage. A thermostable protein as used herein comprises a protein that retains catalytic activity at a temperature at or above 32° C., 33° C., 34° C., 35° C., 36° C., 37° C., 38° C., 39° C., 40° C., 41° C., 42° C., 43° C., 44° C., 45° C., 46° C., 47° C., 48° C., 49° C., 50° C., 51° C., 52° C., 53° C., 54° C., 55° C., 56° C., 57° C., 58° C., 59° C., 60° C., 61° C., 62° C., 63° C., 64° C., 65° C., 66° C., 67° C., 68° C., 69° C., 70° C., 71° C., 72° C. In certain example embodiments, the protein is thermostable at or above 55° C.

Methods for identification of thermostable proteins are detailed herein, and may comprise identifying Cas proteins from thermophilic bacterial species. Upon identification of a particular Cas protein from a species, Cas proteins form similar species may be identified.

In certain embodiments, the thermostable CRISPR-Cas protein is a Cas 12 protein from Table 2A or 2B, or at least 80% identity to a polypeptide from Table 2A or 2B.

In certain embodiments, the thermostable CRISPR-Cas protein is a Cas 12 protein from Table 2A or 2B, or at least 80% identity to a polypeptide from Table 2A or 2B. SEQ ID NOS: 61644-61990.

TABLE 2A Cas 12 proteins   Cas 12 proteins (65C)_Ga0209381_1004188 | GENOME_ACCESSION (66C)_a0212093_1 | Ga0212093_1006934 | GENOME_ACCESSION 3300022548 | Ga0212092_1000015 | GENOME_ACCESSION a0117933_1071983 | Ga0117933_1071983 | GENOME_ACCESSION a0212092_1024084 | Ga0212092_1024084 | GENOME_ACCESSION a0212093_1001507 | Ga0212093_1001507 | GENOME_ACCESSION a0212120_1000874 | Ga0212120_1000874 | GENOME_ACCESSION a0212125_1004414 | Ga0212125_1004414 | GENOME_ACCESSION a0212125_1006348 | Ga0212125_1006348 | GENOME_ACCESSION ABHJ01000011.1_o | Hydrogenivirga sp. 128-5-R1-1_1102927038514 AGIV01000002.1_o | Rhodothermus marinus SG0.5JP17-171 Rhoma_Contig848_C BDSM01000053.1_o | Microcystis sp. 0824 DNA BFBB01000008.1_o | Leptospira sp. YH101 DNA BHZK01000001.1_o | Parageobacillus thermoglucosidasius TG4 DNA CP000240.1_organ | Synechococcus sp. JA-2-3B′a(2-13) CP001229.1_organ | Sulfurihydrogenibium azorense Az-Ful CP011339.1_organ | Microcystis panniformis FACHB-1757 CP020382.1_organ | Rhodothermaceae bacterium RA chromosome CP040694.1_organ | Elizabethkingia sp. JS20170427COW chromosome DCUT01000059.1_o | TPA_asm DHGN01000237.1_o | TPA_asm FQUK01000003.1_o | Thermomonas hydrothermalis strain DSM 14834 genome assembly Ga0063162_1014580 | GENOME_ACCESSION Ga0065719_107896 | GENOME_ACCESSION Ga0065719_116807 | GENOME_ACCESSION Ga0067045_1002454 | GENOME_ACCESSION Ga0067045_1004962 | GENOME_ACCESSION] Ga0068669_1023596 | GENOME_ACCESSION Ga0068707_1002163 | GENOME_ACCESSION Ga0068707_1009867 | GENOME_ACCESSION Ga0068707_1024093 | GENOME_ACCESSION Ga0071330_1110381 | GENOME_ACCESSION Ga0072682_101461 | GENOME_ACCESSION Ga0073928_10004924 | GENOME_ACCESSION Ga0073932_1022770 | GENOME_ACCESSION Ga0079044_1002244 | GENOME_ACCESSION Ga0079639_1009487 | GENOME_ACCESSION Ga0099914_10727 | GENOME_ACCESSION Ga0101790_149349 | GENOME_ACCESSION Ga0102924_1013089 | GENOME_ACCESSION Ga0103818_10095 | GENOME_ACCESSION Ga0105154_1006902 | GENOME_ACCESSION Ga0105158_1004615 | GENOME_ACCESSION Ga0114945_10008792 | GENOME_ACCESSION Ga0116141_10037070 | GENOME_ACCESSION Ga0116143_10029534 | GENOME_ACCESSION Ga0116146_1004071 | GENOME_ACCESSION Ga0116159_1001590 | GENOME_ACCESSION Ga0116160_1008286 | GENOME_ACCESSION Ga0116161_1004008 | GENOME_ACCESSION Ga0116167_1006930 | GENOME_ACCESSION Ga0116184_10002336 | GENOME_ACCESSION Ga0116185_1015740 | GENOME_ACCESSION Ga0116188_1022712 | GENOME_ACCESSION Ga0116210_1003377 | GENOME_ACCESSION Ga0123519_10000481 | GENOME_ACCESSION Ga0123519_10002165 | GENOME_ACCESSION Ga0123519_10002912 | GENOME_ACCESSION Ga0123519_10003344 | GENOME_ACCESSION Ga0123519_10003852 | GENOME_ACCESSION Ga0123519_10021143 | GENOME_ACCESSION Ga0123519_10027137 | GENOME_ACCESSION Ga0123519_10057643 | GENOME_ACCESSION Ga0123519_10064432 | GENOME_ACCESSION Ga0124943_1106748 | GENOME_ACCESSION Ga0124945_1030784 | GENOME_ACCESSION Ga0133944_1001807 | GENOME_ACCESSION Ga0134095_1000962 | GENOME_ACCESSION Ga0137716_10003017 | GENOME_ACCESSION Ga0137716_10003038 | GENOME_ACCESSION Ga0137716_10003531 | GENOME_ACCESSION Ga0137716_10006890 | GENOME_ACCESSION Ga0137716_10009026 | GENOME_ACCESSION Ga0137716_10009341 | GENOME_ACCESSION Ga0137716_10027208 | GENOME_ACCESSION Ga0137716_10032400 | GENOME_ACCESSION Ga0137716_10033855 | GENOME_ACCESSION Ga0137716_10038387 | GENOME_ACCESSION Ga0137716_10042212 | GENOME_ACCESSION Ga0137716_10061480 | GENOME_ACCESSION Ga0172363_10016551 | GENOME_ACCESSION Ga0172365_10006450 | GENOME_ACCESSION Ga0172382_10012866 | GENOME_ACCESSION Ga0180300_10000403 | GENOME_ACCESSION Ga0180301_10011215 | GENOME_ACCESSION Ga0180435_10008691 | GENOME_ACCESSION Ga0180446_1198 | GENOME_ACCESSION Ga0181613_1004254 | GENOME_ACCESSION Ga0181613_1005053 | GENOME_ACCESSION Ga0181858_1004277 | GENOME_ACCESSION Ga0182014_10001887 | GENOME_ACCESSION Ga0186994_110 | GENOME_ACCESSION Ga0187028_105 | GENOME_ACCESSION Ga0187073_104 | GENOME_ACCESSION Ga0187107_1033 | GENOME_ACCESSION Ga0187121_108 | GENOME_ACCESSION Ga0187143_105 | GENOME_ACCESSION Ga0187864_10009485 | GENOME_ACCESSION Ga0190309_1003062 | GENOME_ACCESSION Ga0190334_1000016 | GENOME_ACCESSION Ga0190361_1000443 | GENOME_ACCESSION Ga0190361_1001609 | GENOME_ACCESSION Ga0190361_1003780 | GENOME_ACCESSION 27 Ga0190361_1003780 | GENOME_ACCESSION 31 Ga0190363_1000125 | GENOME_ACCESSION Ga0194111_10067953 | GENOME_ACCESSION Ga0207429_10023 | GENOME_ACCESSION Ga0207433_10006213 | GENOME_ACCESSION Ga0207433_10011113 | GENOME_ACCESSION Ga0207433_10012523 | GENOME_ACCESSION Ga0207433_10020534 | GENOME_ACCESSION Ga0207433_10021674 | GENOME_ACCESSION Ga0207433_10022806 | GENOME_ACCESSION Ga0207433_10030792 | GENOME_ACCESSION Ga0207433_10045901 | GENOME_ACCESSION Ga0207433_10075234 | GENOME_ACCESSION Ga0207433_10075916 | GENOME_ACCESSION Ga0207433_10082276 | GENOME_ACCESSION Ga0207747_1007959 | GENOME_ACCESSION Ga0207868_1000002 | GENOME_ACCESSION Ga0208151_102415 | GENOME_ACCESSION Ga0208195_1004385 | GENOME_ACCESSION Ga0208357_1002034 | GENOME_ACCESSION Ga0208429_100128 | GENOME_ACCESSION Ga0208429_100584 | GENOME_ACCESSION Ga0208429_100770 | GENOME_ACCESSION Ga0208461_1008711 | GENOME_ACCESSION Ga0208609_100002 | GENOME_ACCESSION Ga0208683_103187 | GENOME_ACCESSION Ga0208683_103849 | GENOME_ACCESSION Ga0208683_104403 | GENOME_ACCESSION Ga0208940_1001448 | GENOME_ACCESSION Ga0209012_1000842 | GENOME_ACCESSION Ga0209012_1001252 | GENOME_ACCESSION Ga0209012_1015334 | GENOME_ACCESSION Ga0209018_1000172 | GENOME_ACCESSION Ga0209101_1000507 | GENOME_ACCESSION Ga0209101_1006392 | GENOME_ACCESSION Ga0209102_1000334 | GENOME_ACCESSION Ga0209102_1003688 | GENOME_ACCESSION Ga0209143_1000788 | GENOME_ACCESSION Ga0209143_1002248 | GENOME_ACCESSION Ga0209143_1006289 | GENOME_ACCESSION Ga0209162_1014546 | GENOME_ACCESSION Ga0209171_10000726 | GENOME_ACCESSION Ga0209172_10015399 | GENOME_ACCESSION Ga0209201_1007464 | GENOME_ACCESSION Ga0209207_1001084 | GENOME_ACCESSION Ga0209207_1006579 | GENOME_ACCESSION Ga0209224_1000001 | GENOME_ACCESSION Ga0209225_1002268 | GENOME_ACCESSION Ga0209399_10016114 | GENOME_ACCESSION Ga0209410_1010848 | GENOME_ACCESSION Ga0209467_1000554 | GENOME_ACCESSION Ga0209507_1000982 | GENOME_ACCESSION Ga0209513_1002134 | GENOME_ACCESSION Ga0209542_10001012 | GENOME_ACCESSION Ga0209542_10007289 | GENOME_ACCESSION Ga0209669_100016 | GENOME_ACCESSION Ga0209669_101200 | GENOME_ACCESSION Ga0209750_1000252 | GENOME_ACCESSION Ga0209827_10659006 | GENOME_ACCESSION Ga0209980_10011112 | GENOME_ACCESSION Ga0210049_1040060 | GENOME_ACCESSION Ga0210051_1028938 | GENOME_ACCESSION Ga0210057_1032582 | GENOME_ACCESSION Ga0214474_1011027 | GENOME_ACCESSION Ga0255343_1026926 | GENOME_ACCESSION Ga0255346_1002844 | GENOME_ACCESSION Ga0255355_1000451 | GENOME_ACCESSION Ga0255811_11272827 | GENOME_ACCESSION Ga0255812_10127107 | GENOME_ACCESSION Ga0272445_1000517 | GENOME_ACCESSION Ga0272446_1000057 | GENOME_ACCESSION Ga0272446_1000164 | GENOME_ACCESSION Ga0272446_1001728 | GENOME_ACCESSION 137 Ga0272446_1001728 | GENOME_ACCESSION 249 Ga0272446_1001929 | GENOME_ACCESSION Ga0272446_1017314 | GENOME_ACCESSION Ga0272447_1003507 | GENOME_ACCESSION Ga0272448_1000001 | GENOME_ACCESSION Ga0272448_1000002 | GENOME_ACCESSION Ga0272448_1000009 | GENOME_ACCESSION Ga0272448_1000011 | GENOME_ACCESSION Ga0272448_1000062 | GENOME_ACCESSION Ga0272448_1000167 | GENOME_ACCESSION Ga0272448_1002516 | GENOME_ACCESSION Ga0272448_1011735 | GENOME_ACCESSION Ga0272448_1059621 | GENOME_ACCESSION Ga0272448_1067731 | GENOME_ACCESSION Ga0272449_1002236 | GENOME_ACCESSION Ga0272449_1004365 | GENOME_ACCESSION Ga0272449_1006528 | GENOME_ACCESSION Ga0272449_1019852 | GENOME_ACCESSION Ga0302046_10000852 | GENOME_ACCESSION Ga0302192_10026063 | GENOME_ACCESSION Ga0302246_1000265 | GENOME_ACCESSION Ga0302251_1001844 | GENOME_ACCESSION Ga0302253_1002416 | GENOME_ACCESSION Ga0307340_100872 | GENOME_ACCESSION Ga0308310_1004946 | GENOME_ACCESSION Ga0308310_1013800 | GENOME_ACCESSION Ga0308411_10001123 | GENOME_ACCESSION Ga0308411_10021369 | GENOME_ACCESSION Ga0308414_1002480 | GENOME_ACCESSION Ga0308414_1007395 | GENOME_ACCESSION Ga0308414_1018540 | GENOME_ACCESSION Ga0308415_1006042 | GENOME_ACCESSION Ga0308419_1006240 | GENOME_ACCESSION Ga0308419_1011938 | GENOME_ACCESSION Ga0310136_000087 | GENOME_ACCESSION Ga0310138_009337 | GENOME_ACCESSION Ga0310146_00181 | GENOME_ACCESSION Ga0310828_1006812 | GENOME_ACCESSION Ga0311022_13670299 | GENOME_ACCESSION Ga0315269_0011078 | GENOME_ACCESSION Ga0315269_0014929 | GENOME_ACCESSION Ga0315269_0030078 | GENOME_ACCESSION Ga0315277_10001015 | GENOME_ACCESSION Ga0315280_10009663 | GENOME_ACCESSION Ga0315280_10032046 | GENOME_ACCESSION Ga0315282_10006339 | GENOME_ACCESSION Ga0315282_10053614 | GENOME_ACCESSION Ga0315285_10079970 | GENOME_ACCESSION Ga0315288_10142264 | GENOME_ACCESSION Ga0315298_1000517 | GENOME_ACCESSION Ga0315298_1001941 | GENOME_ACCESSION Ga0315298_1005332 | GENOME_ACCESSION Ga0315298_1007399 | GENOME_ACCESSION Ga0315298_1007594 | GENOME_ACCESSION Ga0315298_1015991 | GENOME_ACCESSION Ga0315903_10087816 | GENOME_ACCESSION Ga0334883_1024988 | GENOME_ACCESSION Ga0334884_1015165 | GENOME_ACCESSION Ga0370516_000963 | GENOME_ACCESSION Ga0370516_004838 | GENOME_ACCESSION Ga0370516_008232 | GENOME_ACCESSION Ga0370516_009639 | GENOME_ACCESSION Ga0370516_018229 | GENOME_ACCESSION Ga0370516_020865 | GENOME_ACCESSION Ga0373397_000168 | GENOME_ACCESSION Ga0373621_000479 | GENOME_ACCESSION Ga0373621_007959 | GENOME_ACCESSION Ga0373621_010685 | GENOME_ACCESSION Ga0373621_017562 | GENOME_ACCESSION Ga0373621_020135 | GENOME_ACCESSION Ga0373621_023545 | GENOME_ACCESSION Ga0373621_050562 | GENOME_ACCESSION Ga0373637_0010996 | GENOME_ACCESSION Ga0373637_0021496 | GENOME_ACCESSION Ga0373637_0024972 | GENOME_ACCESSION Ga0373637_0031827 | GENOME_ACCESSION Ga0373637_0034837 | GENOME_ACCESSION Ga0373637_0065620 | GENOME_ACCESSION Ga0374803_055 | GENOME_ACCESSION GCA_000092125.1 | Meiothermus silvanus DSM 9946 plasmid pMESIL02 GCA_000444055.1 | Alicyclobacillus acidoterrestris ATCC 49025 contig_23 GCA_000444055.1 | Alicyclobacillus acidoterrestris ATCC 49025 contig_26 GCA_000832185.1_ASM83218v1 | Bacillus thermoamylovorans strain B4167 NODE_88 GCA_002951815.1_ASM295181v1 | Sulfobacillus thermotolerans strain Kr chromosome GCA_004343255.1_ASM434325v1 | Laceyella sacchari strain DSM 43356 Ga0244645_102 GCA_006503695.1 | Tepidiphilus succinatimandens strain DSM 15512 Scaffold2 GCA_006503695.1_ASM650369v1 | Tepidiphilus succinatimandens strain DSM 15512 Scaffold2 GCA_900116805.1 | Alicyclobacillus macrosporangiidus strain DSM 17980 genome assembly GCA_900129915.1 | Tepidibacterthalassicus DSM 15285 genome assembly JGI12383J13903_1002647 | GENOME_ACCESSION JGI24108J20142_1001595 | GENOME_ACCESSION JGI24721J44947_10029740 | GENOME_ACCESSION JGI24721J44947_10039167 | GENOME_ACCESSION JGI26463J51803_1000081 | GENOME_ACCESSION KE386988.1_organ | Desulfatirhabdium butyrativorans DSM 18734 genomic scaffold G492DRAFT_scaffold00017.17 KE387196.1_organ | Tuberibacillus calidus DSM 17572 genomic scaffold H532DRAFT_scaffold00011.il LGRA01000008.1_o | Azospirillum sp. TSO35-2 Contig02 LNAA02000020.1_o | Oscillateriales cyanobacterium MTP1 Contig_26 mgm4742482.3 | NODE_1674_length_13888_cov_ 4.96582_ID_49155357 | GENOME_ACCESSION MHOL01000010.1_o | Candidatus Staskawiczbacteria bacterium RIFCSPHIGHO2_01_FULL_34_27 rifcsphigho2_01_scaffold_2126 MHPA01000001.1_o | Candidatus Staskawiczbacteria bacterium RIFCSPLOWO2_01_FULL_38_12b rifcsplowo2_01_scaffold_12327 MTKY01071110.1_o | Anaerobic digester metagenome soeholt_digester_71110 MVGR01000004.1_o | Microcystis aeruginosa KW Contig4 NICF_comb_assmDRAFT_10010420 | GENOME_ACCESSION NJDI01000010.1_o | Archaeoglobales archaeon ex4484_92 ex4484_82_scaffold_1630_length_14867_count_1478 OGCG01005283.1_o | hot springs metagenome genome assembly OGCG01007631.1_o | hot springs metagenome genome assembly OKRQ01000045.1_o | freshwater metagenome genome assembly OQOO01000421.1_o | human oral metagenome genome assembly OQUW01.1 | hot springs metagenome genome assembly OQUW01000094.1_o | hot springs metagenome genome assembly OQUW01000235.1_o | hot springs metagenome genome assembly OQUW01001775.1_o | hot springs metagenome genome assembly ORXB01007227.1_o | sediment metagenome genome assembly OVXJ01001238.1_o | sediment metagenome genome assembly QNAW01000106.1_o | Thermodesulfobacteria bacterium isolate B8_G2B8_Guay2_scaffold_12966 UOVV01006324.1_o | compost metagenome genome assembly UPSJ01002360.1_o | activated sludge metagenome genome assembly YNPsite07_CeleraDRAF_scf1119010704098 | GENOME_ACCESSION Ga0065721_10050166 | GENOME_ACCESSION: BioRi 2199352012 $F 3300005286 GENOME ID: 23829 CONTIG ID: 14524 Ga0255812_10583625 | GENOME ACESSION: IMG 3300023203 $F 3300023203 GENOME ID: 30040 CONTIG ID: 32030 Ga0265297_10015673 | GENOME ACESSION: Munlaniwel113791 2 $F 3300029288 GENOME ID: 280701 CONTIG ID: 15672 Ga0315280_10014676 | GENOME_ACESSION: YL17G06_40_MG_2_$F_3300031862 GENOME_ID: 281631 CONTIG_ID: 14675 Ga0206102_1000160 | GENOME ACESSION: 1B1Ametagenome 2 $F 3300020149 GENOME ID: 20785 CONTIG ID: 159 Ga0207869_1001742 | GENOME ACESSION: HigsolAR5DSPAdes $F 3300025517 GENOME ID: 27181 CONTIG ID: 1741 Ga0209347_1001125 | GENOME ACESSION: AutmicBR23SPAdes $F 3300027640 GENOME ID: 23478 CONTIG ID: 1124 Alicyclobacillus kakegawensis NBRC 103104 DNA, contig: AK2_CON0027_0001, whole genome shotgun sequence | GENOME_ACESSION: GCA_001552655.1 ASM155265v1 genomic GENOME ID: 98642 CONTIG ID: 26 FNOJ0100000035.1 Alicyclobacillus hesperidum strain DSM 12489 genome assembly, contig: Ga0074806_135, whole genome shotgun sequence | GENOME_ACESSION: GCA_900107035.1 IMG-taxon 2634166329 annotated assembly genomic GENOME ID: 184129 CONTIG ID: 49 OQOO010000421.1 human oral metagenome genome assembly, contig: NODE_421_length_10358_cov_14.800155, whole genome shotgun sequence | GENOME_ACESSION: OQOO01.1 GENOME ID: 9995 CONTIG ID: 420 bioreactor metagenome genome assembly, contig: NODE_247_length_93349_cov_7.384563, whole genome shotgun sequence | GENOME_ACCESSION: OWPA01.1 GENOME ID: 12159 CONTIG ID: 246 PGUZ01000040.1 Bacillus sp. V3-13 contig_40, whole genome shotgun sequence | GENOME_ACCESSION: GCA_002860165.1_ ASM286016v1_genomic GENOME_ID: 150146 CONTIG ID: 56 RHHN01000007.1 Brevibacillus agri strain NRRL NRS 1219 contig_7, whole genome shotgun sequence | GENOME_ACCESSION: GCA_003710885.1_ASM371088v1_genomic GENOME ID: 202321 CONTIG ID: 115 RHHS01000035.1 Brevibacillus gelatini strain DSM 100115 contig_35, whole genome shotgun sequence | GENOME_ACESSION: GCA_003710935.1_ASM371093v1_genomic GENOME ID: 202324 CONTIG ID: 28 AacCas12b AapCas12b BrCas12b

TABLE 2B Cas12 proteins   Cas 12 proteins (65C) Ga0209381_1004188 | GENOME_ACCESSION a0212093_1001507 | Ga0212093_1001507 | GENOME_ACCESSION DCUT01000059.1_o | TPA_asm: Syntrophaceae bacterium UBA2207 UBA2207_contig_83649, whole genome shotgun sequence | GENOME_ACESSION: GCA_002328545.1_ASM232854v1_genomic GENOME_ID: 131523 CONTIG_ID: 133 FQUK01000003.1_o | Thermomonas hydrothermalis strain DSM 14834 genome assembly Ga0067045_1002454 | GENOME_ACCESSION Ga0067045_1004962 | GENOME_ACCESSION] Ga0116159_1001590 | GENOME_ACCESSION Ga0116160_1008286 | GENOME_ACCESSION Ga0116161_1004008 | GENOME_ACCESSION Ga0116167_1006930 | GENOME_ACCESSION Ga0116184_10002336 | GENOME_ACCESSION Ga0123519_10002912 | GENOME_ACCESSION Ga0123519_10003852 | GENOME_ACCESSION Ga0137716_10027208 | GENOME_ACCESSION Ga0172382_10012866 | GENOME_ACCESSION Ga0180435_10008691 | GENOME_ACCESSION Ga0182014_10001887 | GENOME_ACCESSION Ga0187107_1033 | GENOME_ACCESSION Ga0187864_10009485 | GENOME_ACCESSION Ga0208195_1004385 | GENOME_ACCESSION Ga0208357_1002034 | GENOME_ACCESSION Ga0208609_100002 | GENOME_ACCESSION Ga0209012_1001252 | GENOME_ACCESSION Ga0209018_1000172 | GENOME_ACCESSION Ga0209507_1000982 | GENOME_ACCESSION Ga0209513 1002134 | GENOME_ACCESSION Ga0255346_1002844 | GENOME_ACCESSION Ga0255812_10127107 | GENOME_ACCESSION Ga0272448_1000001 | GENOME_ACCESSION Ga0272448_1000009 | GENOME_ACCESSION Ga0272448_1000167 | GENOME_ACCESSION Ga0272448_1002516 | GENOME_ACCESSION Ga0302246_1000265 | GENOME_ACCESSION Ga0302251_1001844 | GENOME_ACCESSION Ga0302253_1002416 | GENOME_ACCESSION Ga0310136_000087 | GENOME_ACCESSION Ga0315298_1005332 | GENOME_ACCESSION Ga0315298_1015991 | GENOME_ACCESSION Ga0334884_1015165 | GENOME_ACCESSION Ga0373637_0010996 | GENOME_ACCESSION Ga0373637_0024972 | GENOME_ACCESSION Ga0373637_0031827 | GENOME_ACCESSION GCA_000444055.1 | Alicyclobacillus acidoterrestris ATCC 49025 contig_26 GCA_000832185.1_ASM83218v1 | Bacillus thermoamylovorans strain B4167 NODE_88 GCA_002951815.1_ASM295181v1 | Sulfobacillus thermotolerans strain Kr chromosome GCA_004343255.1_ASM434325v1 | Laceyella sacchari strain DSM 43356 Ga0244645_102 GCA_900116805.1 | Alicyclobacillus macrosporangiidus strain DSM 17980 genome assembly KE386988.1_organ | Desulfatirhabdium butyrativorans DSM 18734 genomic scaffold G492DRAFT_scaffold00017.17 KE387196.1_organ | Tuberibacillus calidus DSM 17572 genomic scaffold H532DRAFT scaffold00011.11 LNAA02000020.1_o | Oscillatoriales cyanobacterium MTP1 Contig_26 OQUW01000094.1_o | hot springs metagenome genome assembly OQUW01001775.1_o | hot springs metagenome genome assembly Ga0255812_10583625 | GENOME_ACESSION: IMG_3300023203_$F_3300023203 GENOME_ID: 30040 CONTIG_ID: 32030 Ga0065721_10050166 | GENOME_ACCESSION: BioRi_2199352012_$F_3300005286 GENOME_ID: 23829 CONTIG_ID: 14524 Ga0265297_10015673 | GENOME_ACESSION: Munlanlwel113791_2_$F_3300029288 GENOME_ID: 280701 CONTIG_ID: 15672 Ga0315280_10014676 | GENOME_ACESSION: YL17G06_40_MG_2_$F_3300031862 GENOME_ID: 281631 CONTIG_ID: 14675 Ga0206102_1000160 | GENOME_ACESSION: 1B1Ametagenome_2_$F_3300020149 GENOME_ID: 20785 CONTIG_ID: 159 Ga0207869_1001742 | GENOME_ACESSION: HigsolAR5DSPAdes_$F_3300025517 GENOME_ID: 27181 CONTIG_ID: 1741 Ga0209347_1001125 | GENOME ACESSION: AutmicBR23SPAdes_$F_3300027640 GENOME_ID: 23478 CONTIG_ID: 1124 Alicyclobacillus kakegawensis NBRC 103104 DNA, contig: AK2_CON0027_0001, whole genome shotgun sequence | GENOME_ACESSION: GCA_001552655.1_ ASM155265v1_genomic GENOME_ID: 98642 CONTIG_ID: 26 FNOJ0100000035.1 Alicyclobacillus hesperidum strain DSM 12489 genome assembly, contig: Ga0074806_135, whole genome shotgun sequence | GENOME_ACESSION: GCA_900107035.1_IMG- taxon_2634166329_annotated_assembly_genomic GENOME_ID: 184129 CONTIG_ID: 49 OQOO010000421.1 human oral metagenome genome assembly, contig: NODE_421_length_10358_cov_14.800155, whole genome shotgun sequence | GENOME_ACESSION: OQOO01.1 GENOME_ID: 9995 CONTIG_ID: 420 bioreactor metagenome genome assembly, contig: NODE_247_length_93349_cov_7.384563, whole genome shotgun sequence | GENOME_ACCESSION: OWPA01.1 GENOME_ID: 12159 CONTIG_ID: 246 PGUZ01000040.1 Bacillus sp. V3-13 contig_40, whole genome shotgun sequence | GENOME_ACCESSION: GCA_002860165.1_ASM286016v1_genomic GENOME_ID: 150146 CONTIG_ID: 56 RHHN01000007.1 Brevibacillus agri strain NRRL NRS 1219 contig_7, whole genome shotgun sequence | GENOME_ACCESSION: GCA_003710885.1_ ASM371088v1_genomic GENOME_ID: 202321 CONTIG ID: 115 RHHS01000035.1 Brevibacillus gelatini strain DSM 100115 contig_35, whole genome shotgun sequence | GENOME_ACESSION: GCA_003710935.1_ ASM371093v1_genomic GENOME_ID: 202324 CONTIG_ID: 28 AacCas12b AapCas12b BrCas12b

In certain embodiments, the CRISPR-Cas protein is a Cas12b from a thermostable species, for example Alicyclobacillus acidiphilus (Aap). Cas 12a proteins can be identified from similar organisms as identified in any of BROD_5090P4_Cas12b_sequences.txt. In certain embodiments, the thermostable CRISPR-Cas protein is a Cas13a. In an aspect, the Cas13a thermostable protein is from FIG. 1A of U.S. Provisional Application 62/967,408, filed Jan. 29, 2020, entitled “Novel CRISPR Enzymes and Systems” which were identified from stable anaerobic thermophilic methanogenic microbiomes fermenting switchgrass, supporting their thermostability. See, Liang et al., Biotechnol Biofuels 2018; 11:243 doi: 10.1186/s13068-018-1238-1. Similarly, the 0J26742_10014101 clusters with the verified thermophilic sourced Cas13a sequences detailed in FIG. 1A of U.S. Provisional Application 62/967,408, filed Jan. 29, 2020, entitled “Novel CRISPR Enzymes and Systems”. The nucleic acid identified at loci 123519_10037894 was identified from a study focusing on 70° C. organism. In certain example embodiments, the Cas13 orthologue has at least two HEPN domains and at least 80% identity to a polypeptide encoded by the nucleic acid sequence 0123519_10037894 or 0J26742_10014101.

Certain example embodiments disclosed herein provide are based on low-cost CRISPR-based diagnostic that enables single-molecule detection of DNA or RNA with single-nucleotide specificity (Gootenberg, 2018; Gootenberg, et al, Science. 2017 Apr. 28; 356(6336):438-442 (2017); Myhrvold, et al., Science 360, 444-448 (2018)). Nucleic acid detection with SHERLOCK relies on the collateral activity of Type VI and Type V Cas proteins, such as Cas13 and Cas12, which unleashes promiscuous cleavage of reporters upon target detection (Gooteneberg et al., 2018)(Abudayyeh, et al., Science. 353(6299)(2016); East-Seletsky et al. Nature 538:270-273 (2016); Smargon et al. Mol Cell 65(4):618-630 (2017)). Certain embodiments disclosed herein, are capable of single-molecule detection in less than an hour and can be used for multiplexed target detection when using CRISPR enzymes with orthogonal cleavage preference, such as Cas13a from Leptotrichia wadei (LwaCas13a), Cas13b from Capnocytophaga canimorsus Cc5 (CcaCas13b), and Cas12a from Acidaminococcus sp. BV3L6 (AsCas12a); Alicyclobacillus acidiphilus (Aap) Cas 12b and Brevibacillus sp. SYSU G02855 (BrCas12b); (Gootenberg, 2018; Myhrvold et al. Science 360(6387):444-448 (2018); Gootenberg, 2017; Chen et al. Science 360(6387):436-439 (2018); Li et al. Cell Rep 25(12):3262-3272 (2018); Li et al. Nat Protoc 13(5):899-914 (2018)). Guide molecules used herein are designed using a model for high activity-based Cas guide selection for coronavirus would facilitate design of optimal diagnostic assays, especially in applications requiring high-activity guides like lateral flow detection, and enable guide RNA design for in vivo RNA targeting applications with Cas13 has also been detailed in U.S. Provisional Applications 62/818,702 filed Mar. 14, 2019, now PCT/US20/22795 and 62/890,555, filed Aug. 22, 2019, now PCT/US20/22795, both entitled CRISPR Effector System Based Multiplex Diagnostics, incorporated herein by reference in their entirety, and, in particular, Examples 1-4, Tables 1-8 and FIG. 4A of U.S. Provisional Application 62/890,555.

Embodiments disclosed herein utilize Cas proteins possessing non-specific nuclease collateral activity to cleave detectable reporters upon target recognition, providing sensitive and specific diagnostics, including single nucleotide variants, detection based on rRNA sequences, screening for drug resistance, monitoring microbe outbreaks, genetic perturbations, and screening of environmental samples, as described, for example, in PCT/US18/054472 filed Oct. 22, 2018 at [0183]-[0327], incorporated herein by reference. Reference is made to WO 2017/219027, WO2018/107129, US20180298445, US 2018-0274017, US 2018-0305773, WO 2018/170340, U.S. application Ser. No. 15/922,837, filed Mar. 15, 2018 entitled “Devices for CRISPR Effector System Based Diagnostics”, PCT/US18/50091, filed Sep. 7, 2018 “Multi-Effector CRISPR Based Diagnostic Systems”, PCT/US18/66940 filed Dec. 20, 2018 entitled “CRISPR Effector System Based Multiplex Diagnostics”, PCT/US18/054472 filed Oct. 4, 2018 entitled “CRISPR Effector System Based Diagnostic”, U.S. Provisional 62/740,728 filed Oct. 3, 2018 entitled “CRISPR Effector System Based Diagnostics for Hemorrhagic Fever Detection”, U.S. Provisional 62/690,278 filed Jun. 26, 2018 and U.S. Provisional 62/767,059 filed Nov. 14, 2018 both entitled “CRISPR Double Nickase Based Amplification, Compositions, Systems and Methods”, U.S. Provisional 62/690,160 filed Jun. 26, 2018 and U.S. Pat. No. 62,767,077 filed Nov. 14, 2018, both entitled “CRISPR/CAS and Transposase Based Amplification Compositions, Systems, And Methods”, U.S. Provisional 62/690,257 filed Jun. 26, 2018 and 62/767,052 filed Nov. 14, 2018 both entitled “CRISPR Effector System Based Amplification Methods, Systems, And Diagnostics”, U.S. Provisional 62/767,076 filed Nov. 14, 2018 entitled “Multiplexing Highly Evolving Viral Variants With SHERLOCK” and 62/767,070 filed Nov. 14, 2018 entitled “Droplet SHERLOCK.” Reference is further made to WO2017/127807, WO2017/184786, WO 2017/184768, WO 2017/189308, WO 2018/035388, WO 2018/170333, WO 2018/191388, WO 2018/213708, WO 2019/005866, PCT/US18/67328 filed Dec. 21, 2018 entitled “Novel CRISPR Enzymes and Systems”, PCT/US18/67225 filed Dec. 21, 2018 entitled “Novel CRISPR Enzymes and Systems” and PCT/US18/67307 filed Dec. 21, 2018 entitled “Novel CRISPR Enzymes and Systems”, U.S. 62/712,809 filed Jul. 31, 2018 entitled “Novel CRISPR Enzymes and Systems”, U.S. 62/744,080 filed Oct. 10, 2018 entitled “Novel Cas12b Enzymes and Systems” and U.S. 62/751,196 filed Oct. 26, 2018 entitled “Novel Cas12b Enzymes and Systems”, U.S. 715,640 filed August 7, 2-18 entitled “Novel CRISPR Enzymes and Systems”, WO 2016/205711, U.S. Pat. No. 9,790,490, WO 2016/205749, WO 2016/205764, WO 2017/070605, WO 2017/106657, and WO 2016/149661, WO2018/035387, WO2018/194963, Cox DBT, et al., RNA editing with CRISPR-Cas13, Science. 2017 Nov. 24; 358(6366):1019-1027; Gootenberg J S, et al., Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6., Science. 2018 Apr. 27; 360(6387):439-444; Gootenberg J S, et al., Nucleic acid detection with CRISPR-Cas13a/C2c2., Science. 2017 Apr. 28; 356(6336):438-442; Abudayyeh 00, et al., RNA targeting with CRISPR-Cas13, Nature. 2017 Oct. 12; 550(7675):280-284; Smargon A A, et al., Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28. Mol Cell. 2017 Feb. 16; 65(4):618-630.e7; Abudayyeh 00, et al., C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector, Science. 2016 Aug. 5; 353 (6299):aaf5573; Yang L, et al., Engineering and optimising deaminase fusions for genome editing. Nat Commun. 2016 Nov. 2; 7:13330, Myhrvold et al., Field deployable viral diagnostics using CRISPR-Cas13, Science 2018 360, 444-448, Shmakov et al. “Diversity and evolution of class 2 CRISPR-Cas systems,” Nat Rev Microbiol. 2017 15(3):169-182, each of which is incorporated herein by reference in its entirety.

In general, a CRISPR-Cas or CRISPR system as used herein and in documents, such as WO 2014/093622 (PCT/US2013/074667), refers collectively to transcripts and other elements involved in the expression of or directing the activity of CRISPR-associated (“Cas”) genes, including sequences encoding a Cas gene, a tracr (trans-activating CRISPR) sequence (e.g. tracrRNA or an active partial tracrRNA), a tracr-mate sequence (encompassing a “direct repeat” and a tracrRNA-processed partial direct repeat in the context of an endogenous CRISPR system), a guide sequence (also referred to as a “spacer” in the context of an endogenous CRISPR system), or “RNA(s)” as that term is herein used (e.g., RNA(s) to guide Cas, such as Cas9, e.g. CRISPR RNA and transactivating (tracr) RNA or a single guide RNA (sgRNA) (chimeric RNA)) or other sequences and transcripts from a CRISPR locus. In general, a CRISPR system is characterized by elements that promote the formation of a CRISPR complex at the site of a target sequence (also referred to as a protospacer in the context of an endogenous CRISPR system). When the CRISPR protein is a Cas13 protein, a tracrRNA is not required. Cas13 has been described in Abudayyeh et al. (2016) “C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector”; Science; DOI: 10.1126/science.aaf5573; and Shmakov et al. (2015) “Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems”, Molecular Cell, DOI: dx.doi.org/10.1016/j.molce1.2015.10.008; which are incorporated herein in their entirety by reference. Cas13b has been described in Smargon et al. (2017) “Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNases Differentially Regulated by Accessory Proteins Csx27 and Csx28,” Molecular Cell. 65, 1-13; dx.doi.org/10.1016/j.molce1.2016.12.023., which is incorporated herein in its entirety by reference.

In certain embodiments, protospacer flanking site, or protospacer flanking sequence (PFS) directs binding of the effector proteins (e.g. Type VI) as disclosed herein to the target locus of interest. A PFS is a region that can affect the efficacy of Cas13a mediated targeting, and may be adjacent to the protospacer target in certain Cas13a proteins, while other orthologs do not require a specific PFS. In a preferred embodiment, the CRISPR effector protein may recognize a 3′ PFS. In certain embodiments, the CRISPR effector protein may recognize a 3′ PFS which is 5′H, wherein H is A, C or U. See, e.g. Abudayyeh, 2016. In certain embodiments, the effector protein may be Leptotrichia shahii Cas13p, more preferably Leptotrichia shahii DSM 19757 Cas13, and the 3′ PFS is a 5′ H.

In the context of formation of a CRISPR complex, “target molecule” or “target sequence” or “target nucleic acid” refers to a molecule harboring a sequence, or a sequence to which a guide sequence is designed to have complementarity, where hybridization between a target sequence and a guide sequence promotes the formation of a CRISPR complex. A target sequence may comprise RNA polynucleotides. The term “target RNA” refers to a RNA polynucleotide being or comprising the target sequence. In other words, the target RNA may be a RNA polynucleotide or a part of a RNA polynucleotide to which a part of the gRNA, i.e. the guide sequence, is designed to have complementarity and to which the effector function mediated by the complex comprising CRISPR effector protein and a gRNA is to be directed. In some embodiments, a target sequence is located in the nucleus or cytoplasm of a cell. A target sequence may comprise DNA polynucleotides.

As such, a CRISPR system may comprise RNA-targeting effector proteins. A CRISPR system may comprise DNA-targeting effector proteins. In some embodiments, a CRISPR system may comprise a combination of RNA- and DNA-targeting effector proteins, or effector proteins that target both RNA and DNA.

Other Example Type VI Cas Proteins

In some embodiments, one or more elements of a nucleic acid-targeting system is derived from a particular organism comprising an endogenous CRISPR RNA-targeting system. In certain example embodiments, the effector protein CRISPR RNA-targeting system comprises at least one HEPN domain, including but not limited to the HEPN domains described herein, HEPN domains known in the art, and domains recognized to be HEPN domains by comparison to consensus sequence motifs. Several such domains are provided herein. In one non-limiting example, a consensus sequence can be derived from the sequences of Cas13a or Cas13b orthologs provided herein. In certain example embodiments, the effector protein comprises a single HEPN domain. In certain other example embodiments, the effector protein comprises two HEPN domains.

In one example embodiment, the effector protein comprises one or more HEPN domains comprising a RxxxxH motif sequence. The RxxxxH motif sequence can be, without limitation, from a HEPN domain described herein or a HEPN domain known in the art. RxxxxH motif sequences further include motif sequences created by combining portions of two or more HEPN domains. As noted, consensus sequences can be derived from the sequences of the orthologs disclosed in U.S. Provisional Patent Application 62/432,240 entitled “Novel CRISPR Enzymes and Systems,” U.S. Provisional Patent Application 62/471,710 entitled “Novel Type VI CRISPR Orthologs and Systems” filed on Mar. 15, 2017, and U.S. Provisional Patent Application entitled “Novel Type VI CRISPR Orthologs and Systems,” labeled as attorney docket number 47627-05-2133 and filed on Apr. 12, 2017.

In an embodiment of the invention, a HEPN domain comprises at least one RxxxxH motif comprising the sequence of R(N/H/K)X1X2X3H (SEQ ID NO: 61991-61993). In an embodiment of the invention, a HEPN domain comprises a RxxxxH motif comprising the sequence of R(N/H)X1X2X3H (SEQ ID NO:61991 and SEQ ID NO: 61992). In an embodiment of the invention, a HEPN domain comprises the sequence of R(N/K)X1X2X3H (SEQ ID NO:61991 and SEQ ID NO: 61993). In certain embodiments, X1 is R, S, D, E, Q, N, G, Y, or H. In certain embodiments, X2 is I, S, T, V, or L. In certain embodiments, X3 is L, F, N, Y, V, I, S, D, E, or A.

In particular embodiments, the Type VI RNA-targeting Cas enzyme is Cas13a. In other example embodiments, the Type VI RNA-targeting Cas enzyme is Cas13b. In certain embodiments, the Cas13b protein is from an organism of a genus selected from the group consisting of: Bergeyella, Prevotella, Porphyromonas, Bacterioides, Alistipes, Riemerella, Myroides, Capnocytophaga, Porphyromonas, Flavobacterium, Porphyromonas, Chryseobacterium, Paludibacter, Psychroflexus, Riemerella, Phaeodactylibacter, Sinomicrobium, Reichenbachiella.

In particular embodiments, the homologue or orthologue of a Type VI protein such as Cas13a as referred to herein has a sequence homology or identity of at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with a Type VI protein such as Cas13a (e.g., based on the wild-type sequence of any of Leptotrichia shahii Cas13a, Lachnospiraceae bacterium MA2020 Cas13a, Lachnospiraceae bacterium NK4A179 Cas13a, Clostridium aminophilum (DSM 10710) Cas13a, Carnobacterium gallinarum (DSM 4847) Cas13, Paludibacter propionicigenes (WB4) Cas13, Listeria weihenstephanensis (FSL R9-0317) Cas13, Listeriaceae bacterium (FSL M6-0635) Cas13, Listeria newyorkensis (FSL M6-0635) Cas13, Leptotrichia wadei (F0279) Cas13, Rhodobacter capsulatus (SB 1003) Cas13, Rhodobacter capsulatus (R121) Cas13, Rhodobacter capsulatus (DE442) Cas13, Leptotrichia wadei (Lw2) Cas13, or Listeria seeligeri Cas13). In further embodiments, the homologue or orthologue of a Type VI protein such as Cas13 as referred to herein has a sequence identity of at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with the wild type Cas13 (e.g., based on the wild-type sequence of any of Leptotrichia shahii Cas13, Lachnospiraceae bacterium MA2020 Cas13, Lachnospiraceae bacterium NK4A179 Cas13, Clostridium aminophilum (DSM 10710) Cas13, Carnobacterium gallinarum (DSM 4847) Cas13, Paludibacter propionicigenes (WB4) Cas13, Listeria weihenstephanensis (FSL R9-0317) Cas13, Listeriaceae bacterium (FSL M6-0635) Cas13, Listeria newyorkensis (FSL M6-0635) Cas13, Leptotrichia wadei (F0279) Cas13, Rhodobacter capsulatus (SB 1003) Cas13, Rhodobacter capsulatus (R121) Cas13, Rhodobacter capsulatus (DE442) Cas13, Leptotrichia wadei (Lw2) Cas13, or Listeria seeligeri Cas13).

In certain other example embodiments, the CRISPR system the effector protein is a Cas13 nuclease. The activity of Cas13 may depend on the presence of two HEPN domains. These have been shown to be RNase domains, i.e. nuclease (in particular an endonuclease) cutting RNA. Cas13a HEPN may also target DNA, or potentially DNA and/or RNA. On the basis that the HEPN domains of Cas13a are at least capable of binding to and, in their wild-type form, cutting RNA, then it is preferred that the Cas13a effector protein has RNase function. Regarding Cas13a CRISPR systems, reference is made to U.S. Provisional 62/351,662 filed on Jun. 17, 2016 and U.S. Provisional 62/376,377 filed on Aug. 17, 2016. Reference is also made to U.S. Provisional 62/351,803 filed on Jun. 17, 2016. Reference is also made to U.S. Provisional entitled “Novel Crispr Enzymes and Systems” filed Dec. 8, 2016 bearing Broad Institute No. 10035.PA4 and Attorney Docket No. 47627.03.2133. Reference is further made to East-Seletsky et al. “Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection” Nature doi:10/1038/nature19802 and Abudayyeh et al. “C2c2 is a single-component programmable RNA-guided RNA targeting CRISPR effector” bioRxiv doi:10.1101/054742.

RNase function in CRISPR systems is known, for example mRNA targeting has been reported for certain type III CRISPR-Cas systems (Hale et al., 2014, Genes Dev, vol. 28, 2432-2443; Hale et al., 2009, Cell, vol. 139, 945-956; Peng et al., 2015, Nucleic acids research, vol. 43, 406-417) and provides significant advantages. In the Staphylococcus epidermis type III-A system, transcription across targets results in cleavage of the target DNA and its transcripts, mediated by independent active sites within the Cas10-Csm ribonucleoprotein effector protein complex (see, Samai et al., 2015, Cell, vol. 151, 1164-1174). A CRISPR-Cas system, composition or method targeting RNA via the present effector proteins is thus provided.

In an embodiment, the Cas protein may be a Cas13a ortholog of an organism of a genus which includes but is not limited to Leptotrichia, Listeria, Corynebacter, Sutterella, Legionella, Treponema, Filifactor, Eubacterium, Streptococcus, Lactobacillus, Mycoplasma, Bacteroides, Flaviivola, Flavobacterium, Sphaerochaeta, Azospirillum, Gluconacetobacter, Neisseria, Roseburia, Parvibaculum, Staphylococcus, Nitratifractor, Mycoplasma and Campylobacter. Species of organism of such a genus can be as otherwise herein discussed.

It will be appreciated that any of the functionalities described herein may be engineered into CRISPR enzymes from other orthologs, including chimeric enzymes comprising fragments from multiple orthologs. Examples of such orthologs are described elsewhere herein. Thus, chimeric enzymes may comprise fragments of CRISPR enzyme orthologs of an organism which includes but is not limited to Leptotrichia, Listeria, Corynebacter, Sutterella, Legionella, Treponema, Filifactor, Eubacterium, Streptococcus, Lactobacillus, Mycoplasma, Bacteroides, Flaviivola, Flavobacterium, Sphaerochaeta, Azospirillum, Gluconacetobacter, Neisseria, Roseburia, Parvibaculum, Staphylococcus, Nitratifractor, Mycoplasma and Campylobacter. A chimeric enzyme can comprise a first fragment and a second fragment, and the fragments can be of CRISPR enzyme orthologs of organisms of genera herein mentioned or of species herein mentioned; advantageously the fragments are from CRISPR enzyme orthologs of different species.

In embodiments, the Cas13a protein as referred to herein also encompasses a functional variant of Cas13a or a homologue or an orthologue thereof. A “functional variant” of a protein as used herein refers to a variant of such protein which retains at least partially the activity of that protein. Functional variants may include mutants (which may be insertion, deletion, or replacement mutants), including polymorphs, etc. Also included within functional variants are fusion products of such protein with another, usually unrelated, nucleic acid, protein, polypeptide or peptide. Functional variants may be naturally occurring or may be man-made. Advantageous embodiments can involve engineered or non-naturally occurring Type VI RNA-targeting effector protein.

In an embodiment, nucleic acid molecule(s) encoding the Cas13 or an ortholog or homolog thereof, may be codon-optimized for expression in a eukaryotic cell. A eukaryote can be as herein discussed. Nucleic acid molecule(s) can be engineered or non-naturally occurring.

In an embodiment, the Cas13a or an ortholog or homolog thereof, may comprise one or more mutations (and hence nucleic acid molecule(s) coding for same may have mutation(s). The mutations may be artificially introduced mutations and may include but are not limited to one or more mutations in a catalytic domain. Examples of catalytic domains with reference to a Cas9 enzyme may include but are not limited to RuvC I, RuvC II, RuvC III and HNH domains.

In an embodiment, the Cas13a or an ortholog or homolog thereof, may comprise one or more mutations. The mutations may be artificially introduced mutations and may include but are not limited to one or more mutations in a catalytic domain. Examples of catalytic domains with reference to a Cas enzyme may include but are not limited to HEPN domains.

In an embodiment, the Cas1a3 or an ortholog or homolog thereof, may be used as a generic nucleic acid binding protein with fusion to or being operably linked to a functional domain. Exemplary functional domains may include but are not limited to translational initiator, translational activator, translational repressor, nucleases, in particular ribonucleases, a spliceosome, beads, a light inducible/controllable domain or a chemically inducible/controllable domain.

In certain example embodiments, the Cas13a effector protein may be from an organism selected from the group consisting of; Leptotrichia, Listeria, Corynebacter, Sutterella, Legionella, Treponema, Filifactor, Eubacterium, Streptococcus, Lactobacillus, Mycoplasma, Bacteroides, Flaviivola, Flavobacterium, Sphaerochaeta, Azospirillum, Gluconacetobacter, Neisseria, Roseburia, Parvibaculum, Staphylococcus, Nitratifractor, Mycoplasma, and Campylobacter.

In certain embodiments, the effector protein may be a Listeria sp. Cas13p, preferably Listeria seeligeria Cas13p, more preferably Listeria seeligeria serovar 1/2b str. SLCC3954 Cas13p and the crRNA sequence may be 44 to 47 nucleotides in length, with a 5′ 29-nt direct repeat (DR) and a 15-nt to 18-nt spacer.

In certain embodiments, the effector protein may be a Leptotrichia sp. Cas13p, preferably Leptotrichia shahii Cas13p, more preferably Leptotrichia shahii DSM 19757 Cas13p and the crRNA sequence may be 42 to 58 nucleotides in length, with a 5′ direct repeat of at least 24 nt, such as a 5′ 24-28-nt direct repeat (DR) and a spacer of at least 14 nt, such as a 14-nt to 28-nt spacer, or a spacer of at least 18 nt, such as 19, 20, 21, 22, or more nt, such as 18-28, 19-28, 20-28, 21-28, or 22-28 nt.

In certain example embodiments, the effector protein may be a Leptotrichia sp., Leptotrichia wadei F0279, or a Listeria sp., preferably Listeria newyorkensis FSL M6-0635.

In certain example embodiments, the Cas13 effector proteins of the invention include, without limitation, the following 21 ortholog species (including multiple CRISPR loci: Leptotrichia shahii; Leptotrichia wadei (Lw2); Listeria seeligeri; Lachnospiraceae bacterium MA2020; Lachnospiraceae bacterium NK4A179; [Clostridium] aminophilum DSM 10710; Carnobacterium gallinarum DSM 4847; Carnobacterium gallinarum DSM 4847 (second CRISPR Loci); Paludibacter propionicigenes WB4; Listeria weihenstephanensis FSL R9-0317; Listeriaceae bacterium FSL M6-0635; Leptotrichia wadei F0279; Rhodobacter capsulatus SB 1003; Rhodobacter capsulatus R121; Rhodobacter capsulatus DE442; Leptotrichia buccalis C-1013-b; Herbinix hemicellulosilytica; [Eubacterium] rectale; Eubacteriaceae bacterium CHKCI004; Blautia sp. Marseille-P2398; and Leptotrichia sp. oral taxon 879 str. F0557. Twelve (12) further non-limiting examples are: Lachnospiraceae bacterium NK4A144; Chloroflexus aggregans; Demequina aurantiaca; Thalassospira sp. TSL5-1; Pseudobutyrivibrio sp. OR37; Butyrivibrio sp. YAB3001; Blautia sp. Marseille-P2398; Leptotrichia sp. Marseille-P3007; Bacteroides ihuae; Porphyromonadaceae bacterium KH3CP3RA; Listeria riparia; and Insolitispirillum peregrinum.

In certain embodiments, the Cas13 protein according to the invention is or is derived from one of the orthologues as described, or is a chimeric protein of two or more of the orthologues as described below, or is a mutant or variant of one of the orthologues as described (or a chimeric mutant or variant), including dead Cas13, split Cas13, destabilized Cas13, etc. as defined herein elsewhere, with or without fusion with a heterologous/functional domain.

In certain example embodiments, the Cas13a effector protein is from an organism of a genus selected from the group consisting of: Leptotrichia, Listeria, Corynebacter, Sutterella, Legionella, Treponema, Filifactor, Eubacterium, Streptococcus, Lactobacillus, Mycoplasma, Bacteroides, Flaviivola, Flavobacterium, Sphaerochaeta, Azospirillum, Gluconacetobacter, Neisseria, Roseburia, Parvibaculum, Staphylococcus, Nitratifractor, Mycoplasma, Campylobacter, and Lachnospira.

In an embodiment of the invention, there is provided an effector protein which comprises an amino acid sequence having at least 80% sequence homology to the wild-type sequence of any of Leptotrichia shahii Cas13, Lachnospiraceae bacterium MA2020 Cas13, Lachnospiraceae bacterium NK4A179 Cas13, Clostridium aminophilum (DSM 10710) Cas13, Carnobacterium gallinarum (DSM 4847) Cas13, Paludibacter propionicigenes (WB4) Cas13, Listeria weihenstephanensis (FSL R9-0317) Cas13, Listeriaceae bacterium (FSL M6-0635) Cas13, Listeria newyorkensis (FSL M6-0635) Cas13, Leptotrichia wadei (F0279) Cas13, Rhodobacter capsulatus (SB 1003) Cas13, Rhodobacter capsulatus (R121) Cas13, Rhodobacter capsulatus (DE442) Cas13, Leptotrichia wadei (Lw2) Cas13, or Listeria seeligeri Cas13. According to the invention, a consensus sequence can be generated from multiple Cas13 orthologs, which can assist in locating conserved amino acid residues, and motifs, including but not limited to catalytic residues and HEPN motifs in Cas13 orthologs that mediate Cas13 function. One such consensus sequence, generated from selected orthologs.

In an embodiment of the invention, the effector protein comprises an amino acid sequence having at least 80% sequence homology to a Type VI effector protein consensus sequence including but not limited to a consensus sequence described herein.

In another non-limiting example, a sequence alignment tool to assist generation of a consensus sequence and identification of conserved residues is the MUSCLE alignment tool (www.ebi.ac.uk/Tools/msa/muscle/). For example, using MUSCLE, the following amino acid locations conserved among Cas13a orthologs can be identified in Leptotrichia wadei Cas13a:K2; K5; V6; E301; L331; 1335; N341; G351; K352; E375; L392; L396; D403; F446; 1466; 1470; R474 (HEPN); H475; H479 (HEPN), E508; P556; L561; 1595; Y596; F600; Y669; 1673; F681; L685; Y761; L676; L779; Y782; L836; D847; Y863; L869; 1872; K879; 1933; L954; 1958; R961; Y965; E970; R971; D972; R1046 (HEPN), H1051 (HEPN), Y1075; D1076; K1078; K1080; 11083; 11090.

In certain example embodiments, the RNA-targeting effector protein is a Type VI-B effector protein, such as Cas13b and Group 29 or Group 30 proteins. In certain example embodiments, the RNA-targeting effector protein comprises one or more HEPN domains. In certain example embodiments, the RNA-targeting effector protein comprises a C-terminal HEPN domain, a N-terminal HEPN domain, or both. Regarding example Type VI-B effector proteins that may be used in the context of this invention, reference is made to U.S. application Ser. No. 15/331,792 entitled “Novel CRISPR Enzymes and Systems” and filed Oct. 21, 2016, International Patent Application No. PCT/US2016/058302 entitled “Novel CRISPR Enzymes and Systems”, and filed Oct. 21, 2016, and Smargon et al. “Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentially regulated by accessory proteins Csx27 and Csx28” Molecular Cell, 65, 1-13 (2017); dx.doi.org/10.1016/j.molce1.2016.12.023. In certain example embodiments, the Cas13b effector protein is, or comprises an amino acid sequence having at least 80% sequence homology to any of the sequences of Table 1 of International Patent Application No. PCT/US2016/058302. Further reference is made to example Type VI-B effector proteins of U.S. Provisional Application Nos. 62/471,710, 62/566,829 and International Patent Publication No. WO2018/1703333, entitled “Novel Cas13b Orthologues CRISPR Enzymes and System”. In particular embodiments, the Cas13b enzyme is derived from Bergeyella zoohelcum. In certain other example embodiments, the effector protein is, or comprises an amino acid sequence having at least 80% sequence homology to any of the sequences listed in Tables 1A or 1B of International Patent Publication No. WO2018/1703333, specifically incorporated herein by reference. In certain embodiments, the Cas 13b effector protein is, or comprises an amino acid sequence having at least 80% sequence homology to any of the polypeptides in U.S. Provisional Applications 62/484,791, 62/561,662, 62/568,129 or International Patent Publication WO2018/191388, all entitled “Novel Type VI CRISPR Orthologs and Systems,” incorporated herein by reference. In certain embodiments, the Cas13b effector protein is, or comprises an amino acid sequence having at least 80% sequence homology to a polypeptide as set forth in FIG. 1 of International Patent Publication WO2018/191388, specifically incorporated herein by reference. In an aspect, the Cas13b protein is selected from the group consisting of Porphyromonas gulae Cas13b (accession number WP 039434803), Prevotella sp. P5-125 Cas 13b (accession number WP 044065294), Porphyromonas gingivalis Cas 13b (accession number WP 053444417), Porphyromonas sp. COT-052 OH4946 Cas 13b (accession number WP 039428968), Bacteroides pyogenes Cas 13b (accession number WP 034542281), Riemerella anatipestifer Cas13b (accession number WP 004919755).

In certain example embodiments, the RNA-targeting effector protein is a Cas13c effector protein as disclosed in U.S. Provisional Patent Application No. 62/525,165 filed Jun. 26, 2017, and International Patent Publication No. WO2018/035250 filed Aug. 16, 2017. In certain example embodiments, the Cas13c protein may be from an organism of a genus such as Fusobacterium or Anaerosalibacter. Example wildtype orthologue sequences of Cas13c are: EHO19081, WP 094899336, WP 040490876, WP 047396607, WP 035935671, WP 035906563, WP 042678931, WP 062627846, WP 005959231, WP 027128616, WP 062624740, WP 096402050.

In certain example embodiments, the Cas13 protein may be selected from any of the following: Cas13a: Leptotrichia shahii, Leptotrichia wadei (Lw2), Listeria seeligeri, Lachnospiraceae bacterium MA2020, Lachnospiraceae bacterium NK4A179, [Clostridium] aminophilum DSM 10710, Carnobacterium gallinarum DSM 4847, Carnobacterium gallinarum DSM 4847, Paludibacter propionicigenes WB4, Listeria weihenstephanensis FSL R9-0317, Listeriaceae bacterium FSL M6-0635, Leptotrichia wadei F0279, Rhodobacter capsulatus SB 1003, Rhodobacter capsulatus R121, Rhodobacter capsulatus DE442, Leptotrichia buccalis C-1013-b, Herbinix hemicellulosilytica, [Eubacterium] rectale, Eubacteriaceae bacterium CHKCI004, Blautia sp. Marseille-P2398, Leptotrichia sp. oral taxon 879 str. F0557; Cas 13b: Bergeyella zoohelcum, Prevotella intermedia, Prevotella buccae, Alistipes sp. ZOR0009, Prevotella sp. MA2016, Riemerella anatipestifer, Prevotella aurantiaca, Prevotella saccharolytica, Prevotella intermedia, Capnocytophaga canimorsus, Porphyromonas gulae, Prevotella sp. P5-125, Flavobacterium branchiophilum, Porphyromonas gingivalis, Prevotella intermedia; Cas13c: Fusobacterium necrophorum subsp. funduliforme ATCC 51357 contig00003, Fusobacterium necrophorum DJ-2 contig0065, whole genome shotgun sequence, Fusobacterium necrophorum BFTR-1 contig0068, Fusobacterium necrophorum subsp. funduliforme 1_1_36S cont1.14, Fusobacterium perfoetens ATCC 29250 T364DRAFT_scaffold00009.9_C, Fusobacterium ulcerans ATCC 49185 cont2.38, Anaerosalibacter sp. ND1 genome assembly Anaerosalibacter massiliensis ND1.

In certain example embodiments the orthologue is a Cas13a, Cas13b, Cas13c, or Cas13d. In certain example embodiments the orthologue is a Cas13 orthologue. In certain example embodiments, the Cas13a orthologues is derived from Herbinix hemicellulosilytica. In certain example embodiments, the Cas13a orthologue is derived from Herbinix hemicellulosilytica DSM 29228. In certain example embodiments, the Cas 13 orthologue is defined by SEQ ID NO: 75 of International Publication No. WO 2017/219027. In certain example embodiments, the Cas 13 orthologue is defined by a sequence from FIG. 1A of U.S. Provisional Application 62/967,408, filed Jan. 29, 2020, entitled “Novel CRISPR Enzymes and Systems” (loci QNRW01000010.1, OWPA01000389.1, 0153798_10014618, 0153978_10005171, and 0153798_10004687). In certain example embodiments, the Cas 13a orthologue is encoded by the nucleic acid sequence 0123519_10037894 or 0J26742_10014101. In certain other example embodiments, the Cas13 orthologue has at least 80% sequence identity to SEQ ID NO: 75 of International Publication No. WO 2017/219027. In certain other example embodiments, the Cas13 orthologue has at least 80% sequence identity to sequence from FIG. 1A of U.S. Provisional Application 62/967,408, filed Jan. 29, 2020, entitled “Novel CRISPR Enzymes and Systems” (loci QNRW01000010.1, OWPA01000389.1, 0153798_10014618, 0153978_10005171, and 0153798_10004687), incorporated herein by reference. In certain other example embodiments, the Cas13 orthologue has at least 80% sequence identity to a polypeptide encoded by the nucleic acid sequence 0123519_10037894 or 0J26742_10014101. In certain example embodiments, the Cas13 orthologue has at least one HEPN domain and at least 80% identity to SEQ ID NO: 75 of International Publication No. WO 2017/219027. In certain example embodiments, the Cas13 orthologue has at least one HEPN domain and at least 80% identity to sequence from loci QNRW01000010.1, OWPA01000389.1, 0153798_10014618, 0153978_10005171, and 0153798_10004687. In certain example embodiments, the Cas13 orthologue has at least one HEPN domain and at least 80% identity to a polypeptide encoded by the nucleic acid sequence of 0123519_10037894 or 0J26742_10014101 in BROD-4880P2_Cas13a_sequences.txt. In another example embodiment, the Cas13 orthologue has at least two HEPN domains and at least 80% identity to SEQ ID NO: 75 of International Publication No. WO 2017/219027. In another example embodiment, the Cas13 orthologue has at least two HEPN domains and at least 80% identity to sequence from FIG. 1A of U.S. Provisional Application 62/967,408, filed Jan. 29, 2020, entitled “Novel CRISPR Enzymes and Systems” loci QNRW01000010.1, OWPA01000389.1, 0153798_10014618, 0153978_10005171, and 0153798_10004687. The Cas13a thermostable proteins of FIG. 1A of U.S. Provisional Application 62/967,408, filed Jan. 29, 2020, entitled “Novel CRISPR Enzymes and Systems” were identified from stable anaerobic thermophilic methanogenic microbiomes fermenting switchgrass, supporting their thermostability. See, Liang et al., Biotechnol Biofuels 2018; 11:243 doi: 10.1186/s13068-018-1238-1. Similarly, the 0J26742_10014101 clusters with the verified thermophilic sourced Cas13a sequences detailed in FIG. 1A of U.S. Provisional Application 62/967,408, filed Jan. 29, 2020, entitled “Novel CRISPR Enzymes and Systems”. The nucleic acid identified at loci 123519_10037894 was identified from a study focusing on 70° C. organism. In certain example embodiments, the Cas13 orthologue has at least two HEPN domains and at least 80% identity to a polypeptide encoded by the nucleic acid sequence 0123519_10037894 or 0J26742_10014101. Accordingly, a person of ordinary skill in the art may use characteristics of the above identified orthologs to select other suitable thermostable orthologues from those disclosed herein.

Other Example Type V Cas Proteins

In certain example embodiments, the assays may comprise a DNA-targeting effector protein. In certain example embodiments, the assays may comprise multiple DNA-targeting effectors or one or more orthologs in combination with one or more RNA-targeting effectors. In certain example embodiments, the DNA targeting are Type V Cas proteins, such as Cas12 proteins. In certain other example embodiments, the Cas12 proteins are Cas12a, Cas12b, Cas12c, Cas12d, Cas12e, Cas12g, or a combination thereof.

Cpf1 Orthologs

The present invention encompasses the use of a Cpf1 effector protein, derived from a Cpf1 locus denoted as subtype V-A. Herein such effector proteins are also referred to as “Cpf1p”, e.g., a Cpf1 protein (and such effector protein or Cpf1 protein or protein derived from a Cpf1 locus is also called “CRISPR enzyme”). Presently, the subtype V-A loci encompasses cas1, cas2, a distinct gene denoted cpf1 and a CRISPR array. Cpf1 (CRISPR-associated protein Cpf1, subtype PREFRAN) is a large protein (about 1300 amino acids) that contains a RuvC-like nuclease domain homologous to the corresponding domain of Cas9 along with a counterpart to the characteristic arginine-rich cluster of Cas9. However, Cpf1 lacks the HNH nuclease domain that is present in all Cas9 proteins, and the RuvC-like domain is contiguous in the Cpf1 sequence, in contrast to Cas9 where it contains long inserts including the HNH domain. Accordingly, in particular embodiments, the CRISPR-Cas enzyme comprises only a RuvC-like nuclease domain.

The programmability, specificity, and collateral activity of the RNA-guided Cpf1 also make it an ideal switchable nuclease for non-specific cleavage of nucleic acids. In one embodiment, a Cpf1 system is engineered to provide and take advantage of collateral non-specific cleavage of RNA. In another embodiment, a Cpf1 system is engineered to provide and take advantage of collateral non-specific cleavage of ssDNA. Accordingly, engineered Cpf1 systems provide platforms for nucleic acid detection and transcriptome manipulation. Cpf1 is developed for use as a mammalian transcript knockdown and binding tool. Cpf1 is capable of robust collateral cleavage of RNA and ssDNA when activated by sequence-specific targeted DNA binding.

Homologs and orthologs may be identified by homology modelling (see, e.g., Greer, Science vol. 228 (1985) 1055, and Blundell et al. Eur J Biochem vol 172 (1988), 513) or “structural BLAST” (Dey F, Cliff Zhang Q, Petrey D, Honig B. Toward a “structural BLAST”: using structural relationships to infer function. Protein Sci. 2013 April; 22(4):359-66. doi: 10.1002/pro.2225.). See also Shmakov et al. (2015) for application in the field of CRISPR-Cas loci. Homologous proteins may but need not be structurally related, or are only partially structurally related. The Cpf1 gene is found in several diverse bacterial genomes, typically in the same locus with cas1, cas2, and cas4 genes and a CRISPR cassette (for example, FNFX1_1431-FNFX1_1428 of Francisella cf. novicida Fx1). In particular embodiments, the effector protein is a Cpf1 effector protein from an organism from a genus comprising Streptococcus, Campylobacter, Nitratifractor, Staphylococcus, Parvibaculum, Roseburia, Neisseria, Gluconacetobacter, Azospirillum, Sphaerochaeta, Lactobacillus, Eubacterium, Corynebacter, Carnobacterium, Rhodobacter, Listeria, Paludibacter, Clostridium, Lachnospiraceae, Clostridiaridium, Leptotrichia, Francisella, Legionella, Alicyclobacillus, Methanomethyophilus, Porphyromonas, Prevotella, Bacteroidetes, Helcococcus, Letospira, Desulfovibrio, Desulfonatronum, Opitutaceae, Tuberibacillus, Bacillus, Brevibacilus, Methylobacterium or Acidaminococcus.

In further particular embodiments, the Cpf1 effector protein is from an organism selected from S. mutans, S. agalactiae, S. equisimilis, S. sanguinis, S. pneumonia; C. jejuni, C. coli; N. salsuginis, N. tergarcus; S. auricularis, S. carnosus; N. meningitides, N. gonorrhoeae; L. monocytogenes, L. ivanovii; C. botulinum, C. difficile, C. tetani, C. sordellii.

The effector protein may comprise a chimeric effector protein comprising a first fragment from a first effector protein (e.g., a Cpf1) ortholog and a second fragment from a second effector (e.g., a Cpf1) protein ortholog, and wherein the first and second effector protein orthologs are different. At least one of the first and second effector protein (e.g., a Cpf1) orthologs may comprise an effector protein (e.g., a Cpf1) from an organism comprising Streptococcus, Campylobacter, Nitratifractor, Staphylococcus, Parvibaculum, Roseburia, Neisseria, Gluconacetobacter, Azospirillum, Sphaerochaeta, Lactobacillus, Eubacterium, Corynebacter, Carnobacterium, Rhodobacter, Listeria, Paludibacter, Clostridium, Lachnospiraceae, Clostridiaridium, Leptotrichia, Francisella, Legionella, Alicyclobacillus, Methanomethyophilus, Porphyromonas, Prevotella, Bacteroidetes, Helcococcus, Letospira, Desulfovibrio, Desulfonatronum, Opitutaceae, Tuberibacillus, Bacillus, Brevibacilus, Methylobacterium or Acidaminococcus; e.g., a chimeric effector protein comprising a first fragment and a second fragment wherein each of the first and second fragments is selected from a Cpf1 of an organism comprising Streptococcus, Campylobacter, Nitratifractor, Staphylococcus, Parvibaculum, Roseburia, Neisseria, Gluconacetobacter, Azospirillum, Sphaerochaeta, Lactobacillus, Eubacterium, Corynebacter, Carnobacterium, Rhodobacter, Listeria, Paludibacter, Clostridium, Lachnospiraceae, Clostridiaridium, Leptotrichia, Francisella, Legionella, Alicyclobacillus, Methanomethyophilus, Porphyromonas, Prevotella, Bacteroidetes, Helcococcus, Letospira, Desulfovibrio, Desulfonatronum, Opitutaceae, Tuberibacillus, Bacillus, Brevibacilus, Methylobacterium or Acidaminococcus wherein the first and second fragments are not from the same bacteria; for instance a chimeric effector protein comprising a first fragment and a second fragment wherein each of the first and second fragments is selected from a Cpf1 of S. mutans, S. agalactiae, S. equisimilis, S. sanguinis, S. pneumonia; C. jejuni, C. coli; N. salsuginis, N. tergarcus; S. auricularis, S. carnosus; N. meningitides, N. gonorrhoeae; L. monocytogenes, L. ivanovii; C. botulinum, C. difficile, C. tetani, C. sordellii; Francisella tularensis 1, Prevotella albensis, Lachnospiraceae bacterium MC2017 1, Butyrivibrio proteoclasticus, Peregrinibacteria bacterium GW2011_GWA2_33_10, Parcubacteria bacterium GW2011_GWC2_44_17, Smithella sp. SCADC, Acidaminococcus sp. BV3L6, Lachnospiraceae bacterium MA2020, Candidatus Methanoplasma termitum, Eubacterium eligens, Moraxella bovoculi 237, Leptospira inadai, Lachnospiraceae bacterium ND2006, Porphyromonas crevioricanis 3, Prevotella disiens and Porphyromonas macacae, wherein the first and second fragments are not from the same bacteria. In a more preferred embodiment, the Cpf1p is derived from a bacterial species selected from Francisella tularensis 1, Prevotella albensis, Lachnospiraceae bacterium MC2017 1, Butyrivibrio proteoclasticus, Peregrinibacteria bacterium GW2011_GWA2_33_10, Parcubacteria bacterium GW2011_GWC2_44_17, Smithella sp. SCADC, Acidaminococcus sp. BV3L6, Lachnospiraceae bacterium MA2020, Candidatus Methanoplasma termitum, Eubacterium eligens, Moraxella bovoculi 237, Leptospira inadai, Lachnospiraceae bacterium ND2006, Porphyromonas crevioricanis 3, Prevotella disiens and Porphyromonas macacae. In certain embodiments, the Cpf1p is derived from a bacterial species selected from Acidaminococcus sp. BV3L6, Lachnospiraceae bacterium MA2020. In certain embodiments, the effector protein is derived from a subspecies of Francisella tularensis 1, including but not limited to Francisella tularensis subsp. Novicida.

In some embodiments, the Cpf1p is derived from an organism from the genus of Eubacterium. In some embodiments, the CRISPR effector protein is a Cpf1 protein derived from an organism from the bacterial species of Eubacterium rectale. In some embodiments, the amino acid sequence of the Cpf1 effector protein corresponds to NCBI Reference Sequence WP 055225123.1, NCBI Reference Sequence WP 055237260.1, NCBI Reference Sequence WP 055272206.1, or GenBank ID OLA16049.1. In some embodiments, the Cpf1 effector protein has a sequence homology or sequence identity of at least 60%, more particularly at least 70, such as at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95%, with NCBI Reference Sequence WP 055225123.1, NCBI Reference Sequence WP_055237260.1, NCBI Reference Sequence WP_055272206.1, or GenBank ID OLA16049.1. The skilled person will understand that this includes truncated forms of the Cpf1 protein whereby the sequence identity is determined over the length of the truncated form. In some embodiments, the Cpf1 effector recognizes the PAM sequence of TTTN or CTTN.

In particular embodiments, the homologue or orthologue of Cpf1 as referred to herein has a sequence homology or identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with Cpf1. In further embodiments, the homologue or orthologue of Cpf1 as referred to herein has a sequence identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with the wild type Cpf1. Where the Cpf1 has one or more mutations (mutated), the homologue or orthologue of said Cpf1 as referred to herein has a sequence identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with the mutated Cpf1.

In an ambodiment, the Cpf1 protein may be an ortholog of an organism of a genus which includes, but is not limited to Acidaminococcus sp, Lachnospiraceae bacterium or Moraxella bovoculi; in particular embodiments, the type V Cas protein may be an ortholog of an organism of a species which includes, but is not limited to Acidaminococcus sp. BV3L6; Lachnospiraceae bacterium ND2006 (LbCpf1) or Moraxella bovoculi 237. In particular embodiments, the homologue or orthologue of Cpf1 as referred to herein has a sequence homology or identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with one or more of the Cpf1 sequences disclosed herein. In further embodiments, the homologue or orthologue of Cpf as referred to herein has a sequence identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with the wild type FnCpf1, AsCpf1 or LbCpf1. The skilled person will understand that this includes truncated forms of the Cpf1 protein whereby the sequence identity is determined over the length of the truncated form. In certain of the following, Cpf1 amino acids are followed by nuclear localization signals (NLS) (italics), a glycine-serine (GS) linker, and 3× HA tag. Further Cpf1 orthologs include NCBI WP_055225123.1, NCBI WP_055237260.1, NCBI WP_055272206.1, and GenBank OLA16049.1.

C2c1 Orthologs

The present invention encompasses the use of a C2c1 effector proteins, derived from a C2c1 locus denoted as subtype V-B. Herein such effector proteins are also referred to as “C2c1p”, e.g., a C2c1 protein (and such effector protein or C2c1 protein or protein derived from a C2c1 locus is also called “CRISPR enzyme”). Presently, the subtype V-B loci encompasses cas1-Cas4 fusion, cas2, a distinct gene denoted C2c1 and a CRISPR array. C2c1 (CRISPR-associated protein C2c1) is a large protein (about 1100-1300 amino acids) that contains a RuvC-like nuclease domain homologous to the corresponding domain of Cas9 along with a counterpart to the characteristic arginine-rich cluster of Cas9. However, C2c1 lacks the HNH nuclease domain that is present in all Cas9 proteins, and the RuvC-like domain is contiguous in the C2c1 sequence, in contrast to Cas9 where it contains long inserts including the HNH domain. Accordingly, in particular embodiments, the CRISPR-Cas enzyme comprises only a RuvC-like nuclease domain.

The programmability, specificity, and collateral activity of the RNA-guided C2c1 also make it an ideal switchable nuclease for non-specific cleavage of nucleic acids. In one embodiment, a C2c1 system is engineered to provide and take advantage of collateral non-specific cleavage of RNA. In another embodiment, a C2c1 system is engineered to provide and take advantage of collateral non-specific cleavage of ssDNA. Accordingly, engineered C2c1 systems provide platforms for nucleic acid detection and transcriptome manipulation, and inducing cell death. C2c1 is developed for use as a mammalian transcript knockdown and binding tool. C2c1 is capable of robust collateral cleavage of RNA and ssDNA when activated by sequence-specific targeted DNA binding.

In certain embodiments, C2c1 is provided or expressed in an in vitro system or in a cell, transiently or stably, and targeted or triggered to non-specifically cleave cellular nucleic acids. In one embodiment, C2c1 is engineered to knock down ssDNA, for example viral ssDNA. In another embodiment, C2c1 is engineered to knock down RNA. The system can be devised such that the knockdown is dependent on a target DNA present in the cell or in vitro system, or triggered by the addition of a target nucleic acid to the system or cell.

C2c1 (also known as Cas12b) proteins are RNA guided nucleases. In certain embodiments, the Cas protein may comprise at least 80% sequence identity to a polypeptide as described in International Patent Publication WO 2016/205749 at FIG. 17-21 , FIG. 41A-41M, 44A-44E, incorporated herein by reference. Its cleavage relies on a tracr RNA to recruit a guide RNA comprising a guide sequence and a direct repeat, where the guide sequence hybridizes with the target nucleotide sequence to form a DNA/RNA heteroduplex. Based on current studies, C2c1 nuclease activity also requires relies on recognition of PAM sequence. C2c1 PAM sequences are T-rich sequences. In some embodiments, the PAM sequence is 5′ TTN 3′ or 5′ ATTN 3′, wherein N is any nucleotide. In a particular embodiment, the PAM sequence is 5′ TTC 3′. In a particular embodiment, the PAM is in the sequence of Plasmodium falciparum.

In particular embodiments, the effector protein is a C2c1 effector protein from an organism from a genus comprising Alicyclobacillus, Desulfovibrio, Desulfonatronum, Opitutaceae, Tuberibacillus, Bacillus, Brevibacillus, Candidatus, Desulfatirhabdium, Citrobacter, Elusimicrobia, Methylobacterium, Omnitrophica, Phycisphaerae, Planctomycetes, Spirochaetes, and Verrucomicrobiaceae.

In further particular embodiments, the C2c1 effector protein is from a species selected from Alicyclobacillus acidoterrestris (e.g., ATCC 49025), Alicyclobacillus contaminans (e.g., DSM 17975), Alicyclobacillus macrosporangiidus (e.g. DSM 17980), Bacillus hisashii strain C4, Candidatus Lindowbacteria bacterium RIFCSPLOWO2, Desulfovibrio inopinatus (e.g., DSM 10711), Desulfonatronum thiodismutans (e.g., strain MLF-1), Elusimicrobia bacterium RIFOXYA12, Omnitrophica WOR_2 bacterium RIFCSPHIGHO2, Opitutaceae bacterium TAV5, Phycisphaerae bacterium ST-NAGAB-D1, Planctomycetes bacterium RBG_13_46_10, Spirochaetes bacterium GWB1_27_13, Verrucomicrobiaceae bacterium UBA2429, Tuberibacillus calidus (e.g., DSM 17572), Bacillus thermoamylovorans (e.g., strain B4166), Brevibacillus sp. CF112, Bacillus sp. NSP2.1, Desulfatirhabdium butyrativorans (e.g., DSM 18734), Alicyclobacillus herbarius (e.g., DSM 13609), Citrobacter freundii (e.g., ATCC 8090), Brevibacillus agri (e.g., BAB-2500), Methylobacterium nodulans (e.g., ORS 2060).

In one aspect, the CRISPR-Cas protein is a Cas12b from Table 2A or Table 2B. In certain embodiments, the CRISPR-Cas protein is a Cas12b from a thermostable species, for example Alicyclobacillus acidiphilus (AapCas12b). When the Aap protein is utilized, a related guide can be used, for example from the same or another Alicyclobacillus species, e.g. Alicyclobacillus acidoterrestrus (AacCas12b). In an aspect, the guide comprises at least 95%, 96%, 97% or more sequence identity to the DR and/or the tracr sequence from Aac. In certain embodiments, the AapCas12b protein comprises a sequence with 80%, 85%, 90%, 95% identity to, or consisting of the sequence:

(SEQ ID NO: 61995) MAVKSMKVKLRLDNMPEIRAGLWKLHTEVNAGVRY YTEWLSLLRQENLYRRSPNGDGEQECYKTAEECKA ELLERLRARQVENGHCGPAGSDDELLQLARQLYEL LVPQAIGAKGDAQQIARKFLSPLADKDAVGGLGIA KAGNKPRWVRMREAGEPGWEEEKAKAEARKSTDRT ADVLRALADFGLKPLMRVYTDSDMSSVQWKPLRKG QAVRTWDRDMFQQAIERMMSWESWNQRVGEAYAKL VEQKSRFEQKNFVGQEHLVQLVNQLQQDMKEASHG LESKEQTAHYLTGRALRGSDKVFEKWEKLDPDAPF DLYDTEIKNVQRRNTRRFGSHDLFAKLAEPKYQAL WREDASFLTRYAVYNSIVRKLNHAKMFATFTLPDA TAHPIWTRFDKLGGNLHQYTFLFNEFGEGRHAIRF QKLLTVEDGVAKEVDDVTVPISMSAQLDDLLPRDP HELVALYFQDYGAEQHLAGEFGGAKIQYRRDQLNH LHARRGARDVYLNLSVRVQSQSEARGERRPPYAAV FRLVGDNHRAFVHFDKLSDYLAEHPDDGKLGSEGL LSGLRVMSVDLGLRTSASISVFRVARKDELKPNSE GRVPFCFPIEGNENLVAVHERSQLLKLPGETESKD LRAIREERQRTLRQLRTQLAYLRLLVRCGSEDVGR RERSWAKLIEQPMDANQMTPDWREAFEDELQKLKS LYGICGDREWTEAVYESVRRVWRHMGKQVRDWRKD VRSGERPKIRGYQKDVVGGNSIEQIEYLERQYKFL KSWSFFGKVSGQVIRAEKGSRFAITLREHIDHAKE DRLKKLADRIIMEALGYVYALDDERGKGKWVAKYP PCQLILLEELSEYQFNNDRPPSENNQLMQWSHRGV FQELLNQAQVHDLLVGTMYAAFSSRFDARTGAPGI RCRRVPARCAREQNPEPFPWWLNKFVAEHKLDGCP LRADDLIPTGEGEFFVSPFSAEEGDFHQIHADLNA AQNLQRRLWSDFDISQIRLRCDWGEVDGEPVLIPR TTGKRTADSYGNKVFYTKTGVTYYERERGKKRRKV FAQEELSEEEAELLVEADEAREKSVVLMRDPSGII NRGDWTRQKEFWSMVNQRIEGYLVKQIRSRVRLQE SACENTGDI*.

In an aspect, the CRISPR-Cas protein is a BrCas12b. In certain embodiments, the BrCas12b protein comprises a sequence with 80%, 85%, 90%, 95% identity to, or consisting of the sequence:

(SEQ ID NO: 61996) MPVRSFKVKLVTRSGDAEHMLQLRRGLWKTHEIVN QGIAYYMNKLALMRQEPYAGKSREVVRLELLHSLR AQQKRNNWTGDAGTDDEILNLSRRLYELLVPSAIG EKGDAQMLSRKFLSPLVDPNSEGGKGTAKSGRKPR WMKMREEGHPDWEAEREKDRAKKAADPTASILNDL EAFGLRPLFPLFTDEQKGIQWLPKQKRQFVRTFDR DMFQQALERMLSWESWNRRVAEEYQKLQAQRDELY AKYLADGGAWLEALQSFEKQREVELAEESFAAKSE YLITRRQIRGWKQVYEKWSQLPEHAAQEQFWQVVA DVQTSLPGAFGDPKVYQRGGNIHDYEISQNGKQYQ VTFSRLLWPENETWVERENVTVAIGASQQLKRQIR LDGYADKKQKVRYRDYSSGIELTGVLGGAKIQFDR RHLRKASNRLADGETGPVYLNVVVDIEPFLAMRNG RLQTPIGQVLQVNTKDWPKVTGYKPAELISWIQNS PLAVGTGVNTIEAGMRVMSVDLGQRSAAAVSIFEV MRQKPAEQETKLFYPIAVTGLYAVHRRSLLLRLPG EKISDEIEQQRKIRAHARSLVRYQIRLLADVLRLH TRGTAEQRRAKLDELLATLQTKQELDQKLWQTELE KLFDYIHEPAERWQQALVAAHRTLEPVIGQAVRHW RKSLRIDRKGLAGMSMWNIEELEETRKLLIAWSKH SRVPGEPNRLDKEETFAPQQLQHIQNVKDDRLKQM ANLLVMTALGYKYDEAEKQWKEAYPACQMILFEDL SRYRFALDRPRRENNRLMKWAHRSIPRLVYLQGEL FGIQVGDVYSAYTSRFHAKTGAPGIRCHALKEEDL QPNSYVVKQLIKDGFIREDQTGSLKPGQIVPWSGG ELFVTLADRSGSRLAVIHADINAAQNLQKRFWQQN TEIFRVPCKVTTSGLIPAYDKMKKLFGKGYFAKIN QTDTSEVYVWEHSAKMKGKTTPADPAEEGVFDESL TDEMEELEDSQEGYKTLFRDPSGFFWSSDRWLPQK EFWFWVKRRIEKKLREQLQ.

In an aspect, when the CRISPR-Cas protein is a BrCas12b, the tracrRNA can be selected from one of tracrRNA design 1-tracrRNA design 6 as detailed below: tracrRdesign

1: (SEQ ID NO: 61997) TGCAGGTTAGTGGAAATATAGATAGCCGTTGTGA CTGAGTGACGTGTTAGGTCACCGTAGCACATGAC ACAACTGCACTGGTCAGCCTGTAGCTAACCACCT TCATTATATCTAGTTTTTCCAAC tracrRNA design 2: (SEQ ID NO: 61998) GTTGTGACTGAGTGACGTGTTAGGTCACCGTAGC ACATGACACAACTGCACTGGTCAGCCTGTAGCTA ACCACCTTCATTATATCTAGTTTTTCCAAC tracrRNA design 3: (SEQ ID NO: 61999) TGACACAACTGCACTGGTCAGCCTGTAGCTAACC ACCTTCATTATATCTAGTTTTTCCAAC tracrRNA design 4: (SEQ ID NO: 62000) GAAGGTGGTTAGCTACAGGCTGACCAGTGCAGTT GTGTCATGTGCTACGGTGACCTAACACGTCACTC AGTCACAACGGCTATCTATATTTCCACTAAC tracrRNA design 5: (SEQ ID NO: 62001) GTTGGAAAAACTAGATATAATGAAGGTGGTTAGC TACAGGCTGACCAGTGCAGTTGTGTCATGTGCTA CGGTGACCTAACACGTCACTCAGTCACAACGGCT ATCTATATTTCCACTAAC tracrRNA design 6: (SEQ ID NO: 62002) GTGCAGTTGTGTCATGTGCTACGGTGACCTAACA CGTCACTCAGTCACAACGGCTATCTATATTTCCA CTAAC

In an aspect, when BrCas12b is utilized, the crNA design can be selected from one of crRNAdesign 1 to crRNA design 3, wherein N represents the spacer design:

crRNA design 1: (SEQ ID NO: 62003) GTCCGTTTCGTTAGTGGAAATGTAGATGGTTAGC ACNNNNNNNNNNNNNNNNNNNNNNNNNN crRNA design 2: (SEQ ID NO: 62004) TAGTGGAAATGTAGATGGTTAGCACNNNNNNNNN NNNNNNNNNNNNNNNNNN crRNA design 3 (SEQ ID NO: 62005) GTTAGTGGAAATCTAGATGGTTAGCACNNNNNNN NNNNNNNNNNNNNNNNNNNN

In certain example embodiments, the guide sequence is selected from SEQ ID NOS: 40,500-61,643 or Table 10 or Table 16.

The effector protein may comprise a chimeric effector protein comprising a first fragment from a first effector protein (e.g., a C2c1) ortholog and a second fragment from a second effector (e.g., a C2c1) protein ortholog, and wherein the first and second effector protein orthologs are different. At least one of the first and second effector protein (e.g., a C2c1) orthologs may comprise an effector protein (e.g., a C2c1) from an organism comprising Alicyclobacillus, Desulfovibrio, Desulfonatronum, Opitutaceae, Tuberibacillus, Bacillus, Brevibacillus, Candidatus, Desulfatirhabdium, Elusimicrobia, Citrobacter, Methylobacterium, Omnitrophicai, Phycisphaerae, Planctomycetes, Spirochaetes, and Verrucomicrobiaceae; e.g., a chimeric effector protein comprising a first fragment and a second fragment wherein each of the first and second fragments is selected from a C2c1 of an organism comprising Alicyclobacillus, Desulfovibrio, Desulfonatronum, Opitutaceae, Tuberibacillus, Bacillus, Brevibacillus, Candidatus, Desulfatirhabdium, Elusimicrobia, Citrobacter, Methylobacterium, Omnitrophicai, Phycisphaerae, Planctomycetes, Spirochaetes, and Verrucomicrobiaceae wherein the first and second fragments are not from the same bacteria; for instance a chimeric effector protein comprising a first fragment and a second fragment wherein each of the first and second fragments is selected from a C2c1 of Alicyclobacillus acidoterrestris (e.g., ATCC 49025), Alicyclobacillus contaminans (e.g., DSM 17975), Alicyclobacillus macrosporangiidus (e.g. DSM 17980), Bacillus hisashii strain C4, Candidatus Lindowbacteria bacterium RIFCSPLOWO2, Desulfovibrio inopinatus (e.g., DSM 10711), Desulfonatronum thiodismutans (e.g., strain MLF-1), Elusimicrobia bacterium RIFOXYA12, Omnitrophica WOR_2 bacterium RIFCSPHIGHO2, Opitutaceae bacterium TAV5, Phycisphaerae bacterium ST-NAGAB-D1, Planctomycetes bacterium RBG_13_46_10, Spirochaetes bacterium GWB1_27_13, Verrucomicrobiaceae bacterium UBA2429, Tuberibacillus calidus (e.g., DSM 17572), Bacillus thermoamylovorans (e.g., strain B4166), Brevibacillus sp. CF112, Bacillus sp. NSP2.1, Desulfatirhabdium butyrativorans (e.g., DSM 18734), Alicyclobacillus herbarius (e.g., DSM 13609), Citrobacter freundii (e.g., ATCC 8090), Brevibacillus agri (e.g., BAB-2500), Methylobacterium nodulans (e.g., ORS 2060), wherein the first and second fragments are not from the same bacteria.

In a more preferred embodiment, the C2c1p is derived from a bacterial species selected from Alicyclobacillus acidoterrestris (e.g., ATCC 49025), Alicyclobacillus contaminans (e.g., DSM 17975), Alicyclobacillus macrosporangiidus (e.g. DSM 17980), Bacillus hisashii strain C4, Candidatus Lindowbacteria bacterium RIFCSPLOWO2, Desulfovibrio inopinatus (e.g., DSM 10711), Desulfonatronum thiodismutans (e.g., strain MLF-1), Elusimicrobia bacterium RIFOXYA12, Omnitrophica WOR_2 bacterium RIFCSPHIGHO2, Opitutaceae bacterium TAV5, Phycisphaerae bacterium ST-NAGAB-D1, Planctomycetes bacterium RBG_13_46_10, Spirochaetes bacterium GWB1_27_13, Verrucomicrobiaceae bacterium UBA2429, Tuberibacillus calidus (e.g., DSM 17572), Bacillus thermoamylovorans (e.g., strain B4166), Brevibacillus sp. CF112, Bacillus sp. NSP2.1, Desulfatirhabdium butyrativorans (e.g., DSM 18734), Alicyclobacillus herbarius (e.g., DSM 13609), Citrobacter freundii (e.g., ATCC 8090), Brevibacillus agri (e.g., BAB-2500), Methylobacterium nodulans (e.g., ORS 2060). In certain embodiments, the C2c1p is derived from a bacterial species selected from Alicyclobacillus acidoterrestris (e.g., ATCC 49025), Alicyclobacillus contaminans (e.g., DSM 17975).

In particular embodiments, the homologue or orthologue of C2c1 as referred to herein has a sequence homology or identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with C2c1. In further embodiments, the homologue or orthologue of C2c1 as referred to herein has a sequence identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with the wild type C2c1. Where the C2c1 has one or more mutations (mutated), the homologue or orthologue of said C2c1 as referred to herein has a sequence identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with the mutated C2c1.

In an embodiment, the C2c1 protein may be an ortholog of an organism of a genus which includes, but is not limited to Alicyclobacillus, Desulfovibrio, Desulfonatronum, Opitutaceae, Tuberibacillus, Bacillus, Brevibacillus, Candidatus, Desulfatirhabdium, Elusimicrobia, Citrobacter, Methylobacterium, Omnitrophicai, Phycisphaerae, Planctomycetes, Spirochaetes, and Verrucomicrobiaceae; in particular embodiments, the type V Cas protein may be an ortholog of an organism of a species which includes, but is not limited to Alicyclobacillus acidoterrestris (e.g., ATCC 49025), Alicyclobacillus contaminans (e.g., DSM 17975), Alicyclobacillus macrosporangiidus (e.g. DSM 17980), Bacillus hisashii strain C4, Candidatus Lindowbacteria bacterium RIFCSPLOWO2, Desulfovibrio inopinatus (e.g., DSM 10711), Desulfonatronum thiodismutans (e.g., strain MLF-1), Elusimicrobia bacterium RIFOXYA12, Omnitrophica WOR_2 bacterium RIFCSPHIGHO2, Opitutaceae bacterium TAV5, Phycisphaerae bacterium ST-NAGAB-D1, Planctomycetes bacterium RBG_13_46_10, Spirochaetes bacterium GWB1_27_13, Verrucomicrobiaceae bacterium UBA2429, Tuberibacillus calidus (e.g., DSM 17572), Bacillus thermoamylovorans (e.g., strain B4166), Brevibacillus sp. CF112, Bacillus sp. NSP2.1, Desulfatirhabdium butyrativorans (e.g., DSM 18734), Alicyclobacillus herbarius (e.g., DSM 13609), Citrobacter freundii (e.g., ATCC 8090), Brevibacillus agri (e.g., BAB-2500), Methylobacterium nodulans (e.g., ORS 2060),In particular embodiments, the homologue or orthologue of C2c1 as referred to herein has a sequence homology or identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with one or more of the C2c1 sequences disclosed herein. In further embodiments, the homologue or orthologue of C2c1 as referred to herein has a sequence identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with the wild type AacC2c1 or BthC2c1.

In particular embodiments, the C2c1 protein of the invention has a sequence homology or identity of at least 60%, more particularly at least 70, such as at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with AacC2c1 or BthC2c1. In further embodiments, the C2c1 protein as referred to herein has a sequence identity of at least 60%, such as at least 70%, more particularly at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with the wild type AacC2c1. In particular embodiments, the C2c1 protein of the present invention has less than 60% sequence identity with AacC2c1. The skilled person will understand that this includes truncated forms of the C2c1 protein whereby the sequence identity is determined over the length of the truncated form.

In certain methods according to the present invention, the CRISPR-Cas protein is preferably mutated with respect to a corresponding wild-type enzyme such that the mutated CRISPR-Cas protein lacks the ability to cleave one or both DNA strands of a target locus containing a target sequence. In particular embodiments, one or more catalytic domains of the C2c1 protein are mutated to produce a mutated Cas protein which cleaves only one DNA strand of a target sequence.

In particular embodiments, the CRISPR-Cas protein may be mutated with respect to a corresponding wild-type enzyme such that the mutated CRISPR-Cas protein lacks substantially all DNA cleavage activity. In some embodiments, a CRISPR-Cas protein may be considered to substantially lack all DNA and/or RNA cleavage activity when the cleavage activity of the mutated enzyme is about no more than 25%, 10%, 5%, 1%, 0.1%, 0.01%, or less of the nucleic acid cleavage activity of the non-mutated form of the enzyme; an example can be when the nucleic acid cleavage activity of the mutated form is nil or negligible as compared with the non-mutated form.

In certain embodiments of the methods provided herein the CRISPR-Cas protein is a mutated CRISPR-Cas protein which cleaves only one DNA strand, i.e. a nickase. More particularly, in the context of the present invention, the nickase ensures cleavage within the non-target sequence, i.e. the sequence which is on the opposite DNA strand of the target sequence and which is 3′ of the PAM sequence. By means of further guidance, and without limitation, an arginine-to-alanine substitution (R911A) in the Nuc domain of C2c1 from Alicyclobacillus acidoterrestris converts C2c1 from a nuclease that cleaves both strands to a nickase (cleaves a single strand). It will be understood by the skilled person that where the enzyme is not AacC2c1, a mutation may be made at a residue in a corresponding position. Cas 12c orthologs

In certain embodiments, the effector protein, particularly a Type V loci effector protein, more particularly a Type V-C loci effector protein, even more particularly a C2c3p, may originate, may be isolated or may be derived from a bacterial metagenome selected from the group consisting of the bacterial metagenomes listed in the Table in FIG. 43A-43B of PCT/US2016/038238, specifically incorporated by reference, which presents analysis of the Type-V-C Cas12c loci.

In certain embodiments, the effector protein, particularly a Type V loci effector protein, more particularly a Type V-C loci effector protein, even more particularly a C2c3p, may comprise, consist essentially of or consist of an amino acid sequence selected from the group consisting of amino acid sequences shown in the multiple sequence alignment in FIG. 13I of PCT/US2016/038238, specifically incorporated by reference.

In certain embodiments, a Type V-C locus as intended herein may encode Cas1 and the C2c3p effector protein. See FIG. 14 of PCT/US2016/038238, specifically incorporated by reference, depicting the genomic architecture of the Cas12c CRISPR-Cas loci. In certain embodiments, a Cas1 protein encoded by a Type V-C locus as intended herein may cluster with Type I-B system. See FIGS. 10A and 10B and FIG. 10C-V of PCT/US2016/038238, specifically incorporated by reference, illustrating a Cas1 tree including Cas1 encoded by representative Type V-C loci.

In certain embodiments, the effector protein, particularly a Type V loci effector protein, more particularly a Type V-C loci effector protein, even more particularly a C2c3p, such as a native C2c3p, may be about 1100 to about 1500 amino acids long, e.g., about 1100 to about 1200 amino acids long, or about 1200 to about 1300 amino acids long, or about 1300 to about 1400 amino acids long, or about 1400 to about 1500 amino acids long, e.g., about 1100, about 1200, about 1300, about 1400 or about 1500 amino acids long, or at least about 1100, at least about 1200, at least about 1300, at least about 1400 or at least about 1500 amino acids long.

In certain embodiments, the effector protein, particularly a Type V loci effector protein, more particularly a Type V-C loci effector protein, even more particularly a C2c3p, and preferably the C-terminal portion of said effector protein, comprises the three catalytic motifs of the RuvC-like nuclease (i.e., RuvCI, RuvCII and RuvCIII). In certain embodiments, said effector protein, and preferably the C-terminal portion of said effector protein, may further comprise a region corresponding to the bridge helix (also known as arginine-rich cluster) that in Cas9 protein is involved in crRNA-binding. In certain embodiments, said effector protein, and preferably the C-terminal portion of said effector protein, may further comprise a Zn finger region. Preferably, the Zn-binding cysteine residue(s) may be conserved in C2c3p. In certain embodiments, said effector protein, and preferably the C-terminal portion of said effector protein, may comprise the three catalytic motifs of the RuvC-like nuclease (i.e., RuvCI, RuvCII and RuvCIII), the region corresponding to the bridge helix, and the Zn finger region, preferably in the following order, from N to C terminus: RuvCI-bridge helix-RuvCII-Zinc finger-RuvCIII. See FIGS. 13A and 13C of PCT/US2016/038238, specifically incorporated by reference, for illustration of representative Type V-C effector proteins domain architecture.

In certain embodiments, Type V-C loci as intended herein may comprise CRISPR repeats between 20 and 30 bp long, more typically between 22 and 27 bp long, yet more typically 25 bp long, e.g., 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 bp long.

Orthologous proteins may but need not be structurally related, or are only partially structurally related. In particular embodiments, the homologue or orthologue of a Type V protein such as Cas12c as referred to herein has a sequence homology or identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with a Cas12c. In further embodiments, the homologue or orthologue of a Type V Cas12c as referred to herein has a sequence identity of at least 80%, more preferably at least 85%, even more preferably at least 90%, such as for instance at least 95% with the wild type Cas12c.

In an embodiment, the Type V RNA-targeting Cas protein may be a Cas12c ortholog of an organism of a genus which includes but is not limited to Corynebacter, Sutterella, Legionella, Treponema, Filifactor, Eubacterium, Streptococcus, Lactobacillus, Mycoplasma, Bacteroides, Flaviivola, Flavobacterium, Sphaerochaeta, Azospirillum, Gluconacetobacter, Neisseria, Roseburia, Parvibaculum, Staphylococcus, Nitratifractor, Mycoplasma and Campylobacter.

In an embodiment, the Cas12c or an ortholog or homolog thereof, may comprise one or more mutations (and hence nucleic acid molecule(s) coding for same may have mutation(s). The mutations may be artificially introduced mutations and may include but are not limited to one or more mutations in a catalytic domain. Examples of catalytic domains with reference to a Cas9 enzyme may include but are not limited to RuvC I, RuvC II, RuvC III and HNH domains. In an embodiment, the Cas12c or an ortholog or homolog thereof, may comprise one or more mutations. The mutations may be artificially introduced mutations and may include but are not limited to one or more mutations in a catalytic domain. Examples of catalytic domains with reference to a Cas enzyme may include but are not limited to RuvC I, RuvC II, RuvC III, HNH domains, and HEPN domains.

Guide Sequences

As used herein, the term “guide sequence” and “guide molecule” in the context of a CRISPR-Cas system, comprises any polynucleotide sequence having sufficient complementarity with a target nucleic acid sequence to hybridize with the target nucleic acid sequence and direct sequence-specific binding of a nucleic acid-targeting complex to the target nucleic acid sequence. The guide sequences made using the methods disclosed herein may be a full-length guide sequence, a truncated guide sequence, a full-length sgRNA sequence, a truncated sgRNA sequence, or an E+F sgRNA sequence. In some embodiments, the degree of complementarity of the guide sequence to a given target sequence, when optimally aligned using a suitable alignment algorithm, is about or more than about 50%, 60%, 75%, 80%, 85%, 90%, 95%, 97.5%, 99%, or more. In certain example embodiments, the guide molecule comprises a guide sequence that may be designed to have at least one mismatch with the target sequence, such that a RNA duplex formed between the guide sequence and the target sequence. Accordingly, the degree of complementarity is preferably less than 99%. For instance, where the guide sequence consists of 24 nucleotides, the degree of complementarity is more particularly about 96% or less. In particular embodiments, the guide sequence is designed to have a stretch of two or more adjacent mismatching nucleotides, such that the degree of complementarity over the entire guide sequence is further reduced. For instance, where the guide sequence consists of 24 nucleotides, the degree of complementarity is more particularly about 96% or less, more particularly, about 92% or less, more particularly about 88% or less, more particularly about 84% or less, more particularly about 80% or less, more particularly about 76% or less, more particularly about 72% or less, depending on whether the stretch of two or more mismatching nucleotides encompasses 2, 3, 4, 5, 6 or 7 nucleotides, etc. In some embodiments, aside from the stretch of one or more mismatching nucleotides, the degree of complementarity, when optimally aligned using a suitable alignment algorithm, is about or more than about 50%, 60%, 75%, 80%, 85%, 90%, 95%, 97.5%, 99%, or more. Optimal alignment may be determined with the use of any suitable algorithm for aligning sequences, non-limiting example of which include the Smith-Waterman algorithm, the Needleman-Wunsch algorithm, algorithms based on the Burrows-Wheeler Transform (e.g., the Burrows Wheeler Aligner), ClustalW, Clustal X, BLAT, Novoalign (Novocraft Technologies; available at www.novocraft.com), ELAND (Illumina, San Diego, Calif.), SOAP (available at soap.genomics.org.cn), and Maq (available at maq.sourceforge.net). The ability of a guide sequence (within a nucleic acid-targeting guide RNA) to direct sequence-specific binding of a nucleic acid-targeting complex to a target nucleic acid sequence may be assessed by any suitable assay. For example, the components of a nucleic acid-targeting CRISPR system sufficient to form a nucleic acid-targeting complex, including the guide sequence to be tested, may be provided to a host cell having the corresponding target nucleic acid sequence, such as by transfection with vectors encoding the components of the nucleic acid-targeting complex, followed by an assessment of preferential targeting (e.g., cleavage) within the target nucleic acid sequence, such as by Surveyor assay as described herein. Similarly, cleavage of a target nucleic acid sequence (or a sequence in the vicinity thereof) may be evaluated in a test tube by providing the target nucleic acid sequence, components of a nucleic acid-targeting complex, including the guide sequence to be tested and a control guide sequence different from the test guide sequence, and comparing binding or rate of cleavage at or in the vicinity of the target sequence between the test and control guide sequence reactions. Other assays are possible, and will occur to those skilled in the art. A guide sequence, and hence a nucleic acid-targeting guide RNA may be selected to target any target nucleic acid sequence.

As used herein, the term “guide sequence,” “crRNA,” “guide RNA,” or “single guide RNA,” or “gRNA” refers to a polynucleotide comprising any polynucleotide sequence having sufficient complementarity with a target nucleic acid sequence to hybridize with the target nucleic acid sequence and to direct sequence-specific binding of a RNA-targeting complex comprising the guide sequence and a CRISPR effector protein to the target nucleic acid sequence. In some example embodiments, the degree of complementarity, when optimally aligned using a suitable alignment algorithm, is about or more than about 50%, 60%, 75%, 80%, 85%, 90%, 95%, 97.5%, 99%, or more. Optimal alignment may be determined with the use of any suitable algorithm for aligning sequences, non-limiting example of which include the Smith-Waterman algorithm, the Needleman-Wunsch algorithm, algorithms based on the Burrows-Wheeler Transform (e.g., the Burrows Wheeler Aligner), ClustalW, Clustal X, BLAT, Novoalign (Novocraft Technologies; available at www.novocraft.com), ELAND (Illumina, San Diego, Calif.), SOAP (available at soap.genomics.org.cn), and Maq (available at maq.sourceforge.net). The ability of a guide sequence (within a nucleic acid-targeting guide RNA) to direct sequence-specific binding of a nucleic acid-targeting complex to a target nucleic acid sequence may be assessed by any suitable assay. For example, the components of a nucleic acid-targeting CRISPR system sufficient to form a nucleic acid-targeting complex, including the guide sequence to be tested, may be provided to a host cell having the corresponding target nucleic acid sequence, such as by transfection with vectors encoding the components of the nucleic acid-targeting complex, followed by an assessment of preferential targeting (e.g., cleavage) within the target nucleic acid sequence, such as by Surveyor assay as described herein. Similarly, cleavage of a target nucleic acid sequence may be evaluated in a test tube by providing the target nucleic acid sequence, components of a nucleic acid-targeting complex, including the guide sequence to be tested and a control guide sequence different from the test guide sequence, and comparing binding or rate of cleavage at the target sequence between the test and control guide sequence reactions. Other assays are possible, and will occur to those skilled in the art. A guide sequence, and hence a nucleic acid-targeting guide may be selected to target any target nucleic acid sequence. The target sequence may be DNA. The target sequence may be any RNA sequence. In some embodiments, the target sequence may be a sequence within a RNA molecule selected from the group consisting of messenger RNA (mRNA), pre-mRNA, ribosomal RNA (rRNA), transfer RNA (tRNA), micro-RNA (miRNA), small interfering RNA (siRNA), small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), double stranded RNA (dsRNA), non-coding RNA (ncRNA), long non-coding RNA (lncRNA), and small cytoplasmatic RNA (scRNA). In some preferred embodiments, the target sequence may be a sequence within a RNA molecule selected from the group consisting of mRNA, pre-mRNA, and rRNA. In some preferred embodiments, the target sequence may be a sequence within a RNA molecule selected from the group consisting of ncRNA, and lncRNA. In some more preferred embodiments, the target sequence may be a sequence within an mRNA molecule or a pre-mRNA molecule.

In certain embodiments, the guide sequence or spacer length of the guide molecules is from 15 to 50 nt. In certain embodiments, the spacer length of the guide RNA is at least 15 nucleotides. In certain embodiments, the spacer length is from 15 to 17 nt, e.g., 15, 16, or 17 nt, from 17 to 20 nt, e.g., 17, 18, 19, or 20 nt, from 20 to 24 nt, e.g., 20, 21, 22, 23, or 24 nt, from 23 to 25 nt, e.g., 23, 24, or 25 nt, from 24 to 27 nt, e.g., 24, 25, 26, or 27 nt, from 27-30 nt, e.g., 27, 28, 29, or 30 nt, from 30-35 nt, e.g., 30, 31, 32, 33, 34, or 35 nt, or 35 nt or longer. In certain example embodiment, the guide sequence is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, or 100 nt.

The guide may be derived from a different species than the Cas protein. In certain embodiments, the CRISPR-Cas protein is a Cas12b from a thermostable species, for example Alicyclobacillus acidiphilus (Aap). When the Aap Cas protein is utilized, a related guide can be used, for example from the same or another Alicyclobacillus species, e.g. Alicyclobacillus acidoterrestrus (Aac). In an aspect, the guide comprises at least 95%, 96%, 97% or more sequence similarity to the DR and/or the tracr sequence from Aac Cas12b. The guide can be designed similarly for other Cas proteins, deriving the guide from a different species than the Cas protein species.

In an aspect, the CRISPR-Cas protein is a Cas12b from Aap, and the guide molecule is derived from Aac, or an Alicyclobacillus CRISPR Cas system direct repeat and tracrRNA. In certain embodiments, the guide is designed with a spacer sequence to target a molecule of interest, for example, SARS-CoV-2. While any portion of the SARS-CoV-2 can be targeted, as described elsewhere herein, in an aspect, the spacer is designed to target the Nucleocapsid protein of the SARS-CoV-2. In certain embodiments, the Aac guide has 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence similarity to any one of Type 1 to Type 5 guide sequence below.

In an aspect, the guide comprises:

Type 1: (SEQ ID NO: 62006) GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCA ATGGCCACTTTCCAGGTGGCAAAGCCCGTTGAGC TTCTCAAATCTGAGAAGTGGCAC, Type2: (SEQ ID NO: 62007) GTCTAAAGGACAGAATTTTTCAACGGGTGTGCCA ATGGCCACTTTCCAGGTGGCAAAGCCCGTTGAAC TTCTCAAATCTGAGAAGTGGCAC Type 3: (SEQ ID NO: 62008) GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCA ATGGCCACTTTCCAGGTGGCAAAGCCCGTTGAAC TTCTCAAATCTGAGAAGTGGCAC Type 4: (SEQ ID NO: 62009) GTCTAAAGGACAGAATTTTTCAACGGGTGTGCCA ATGGCCACTTTCCAGGTGGCAAAGCCCGTTGAGC TTCTCAAATCTGAGAAGTGGCAC or Type 5: (SEQ ID NO: 62010) GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCA ATGGCCACTTTCCAGGTGGCAAAGCCCGTTGAAC TTCTCAAATCTGCGAAGTGGCAC.

In certain embodiments, preservation of the underlined portions of the following guide sequence are maintained:

(SEQ ID NO: 62011) GTCTAGAGGACAGAATTTTTCAACGGGTGTGC CAATGGCCACTTTCCAGGTGGCAAAGCCCGTT GAGCTTCTCAAATCTGAGAAGTGGCAC

However, importance of particular bases of the guide sequence are not limited to the underlined areas in SEQ ID NO: 62011, and mutations of these bases can be performed when structure and activity of the guide sequence can be maintained. Such mutations can be tested and optimized in accordance with the guide optimization methods detailed elsewhere herein. In an aspect, the guide preserves the secondary structure as detailed in FIG. 45 . In some embodiments, the sequence of the guide molecule (direct repeat and/or spacer) is selected to reduce the degree secondary structure within the guide molecule. In some embodiments, about or less than about 75%, 50%, 40%, 30%, 25%, 20%, 15%, 10%, 5%, 1%, or fewer of the nucleotides of the nucleic acid-targeting guide RNA participate in self-complementary base pairing when optimally folded. Optimal folding may be determined by any suitable polynucleotide folding algorithm. Some programs are based on calculating the minimal Gibbs free energy. An example of one such algorithm is mFold, as described by Zuker and Stiegler (Nucleic Acids Res. 9 (1981), 133-148). Another example folding algorithm is the online webserver RNAfold, developed at Institute for Theoretical Chemistry at the University of Vienna, using the centroid structure prediction algorithm (see e.g., A. R. Gruber et al., 2008, Cell 106(1): 23-24; and P A Carr and G M Church, 2009, Nature Biotechnology 27(12): 1151-62).

In some embodiments, it is of interest to reduce the susceptibility of the guide molecule to RNA cleavage, such as to cleavage by Cas13. Accordingly, in particular embodiments, the guide molecule is adjusted to avoid cleavage by Cas13 or other RNA-cleaving enzymes.

In certain embodiments, the guide molecule comprises non-naturally occurring nucleic acids and/or non-naturally occurring nucleotides and/or nucleotide analogs, and/or chemically modifications. Preferably, these non-naturally occurring nucleic acids and non-naturally occurring nucleotides are located outside the guide sequence. Non-naturally occurring nucleic acids can include, for example, mixtures of naturally and non-naturally occurring nucleotides. Non-naturally occurring nucleotides and/or nucleotide analogs may be modified at the ribose, phosphate, and/or base moiety. In an embodiment of the invention, a guide nucleic acid comprises ribonucleotides and non-ribonucleotides. In one such embodiment, a guide comprises one or more ribonucleotides and one or more deoxyribonucleotides. In an embodiment of the invention, the guide comprises one or more non-naturally occurring nucleotide or nucleotide analog such as a nucleotide with phosphorothioate linkage, a locked nucleic acid (LNA) nucleotides comprising a methylene bridge between the 2′ and 4′ carbons of the ribose ring, or bridged nucleic acids (BNA). Other examples of modified nucleotides include 2′-O-methyl analogs, 2′-deoxy analogs, or 2′-fluoro analogs. Further examples of modified bases include, but are not limited to, 2-aminopurine, 5-bromo-uridine, pseudouridine, inosine, 7-methylguanosine. Examples of guide RNA chemical modifications include, without limitation, incorporation of 2′-O-methyl (M), 2′-O-methyl 3′phosphorothioate (MS), S-constrained ethyl(cEt), or 2′-O-methyl 3′thioPACE (MSP) at one or more terminal nucleotides. Such chemically modified guides can comprise increased stability and increased activity as compared to unmodified guides, though on-target vs. off-target specificity is not predictable. (See, Hendel, 2015, Nat Biotechnol. 33(9):985-9, doi: 10.1038/nbt.3290, published online 29 Jun. 2015 Ragdarm et al., 0215, PNAS, E7110-E7111; Allerson et al., J. Med. Chem. 2005, 48:901-904; Bramsen et al., Front. Genet., 2012, 3:154; Deng et al., PNAS, 2015, 112:11870-11875; Sharma et al., MedChemComm., 2014, 5:1454-1471; Hendel et al., Nat. Biotechnol. (2015) 33(9): 985-989; Li et al., Nature Biomedical Engineering, 2017, 1, 0066 DOI:10.1038/s41551-017-0066). In some embodiments, the 5′ and/or 3′ end of a guide RNA is modified by a variety of functional moieties including fluorescent dyes, polyethylene glycol, cholesterol, proteins, or detection tags. (See Kelly et al., 2016, J. Biotech. 233:74-83). In certain embodiments, a guide comprises ribonucleotides in a region that binds to a target RNA and one or more deoxyribonucletides and/or nucleotide analogs in a region that binds to Cas13. In an embodiment of the invention, deoxyribonucleotides and/or nucleotide analogs are incorporated in engineered guide structures, such as, without limitation, stem-loop regions, and the seed region. For Cas13 guide, in certain embodiments, the modification is not in the 5′-handle of the stem-loop regions. Chemical modification in the 5′-handle of the stem-loop region of a guide may abolish its function (see Li, et al., Nature Biomedical Engineering, 2017, 1:0066). In certain embodiments, at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, or 75 nucleotides of a guide is chemically modified. In some embodiments, 3-5 nucleotides at either the 3′ or the 5′ end of a guide is chemically modified. In some embodiments, only minor modifications are introduced in the seed region, such as 2′-F modifications. In some embodiments, 2′-F modification is introduced at the 3′ end of a guide. In certain embodiments, three to five nucleotides at the 5′ and/or the 3′ end of the guide are chemicially modified with 2′-O-methyl (M), 2′-O-methyl 3′ phosphorothioate (MS), S-constrained ethyl(cEt), or 2′-O-methyl 3′ thioPACE (MSP). Such modification can enhance genome editing efficiency (see Hendel et al., Nat. Biotechnol. (2015) 33(9): 985-989). In certain embodiments, all of the phosphodiester bonds of a guide are substituted with phosphorothioates (PS) for enhancing levels of gene disruption. In certain embodiments, more than five nucleotides at the 5′ and/or the 3′ end of the guide are chemicially modified with 2′-O-Me, 2′-F or S-constrained ethyl(cEt). Such chemically modified guide can mediate enhanced levels of gene disruption (see Ragdarm et al., 0215, PNAS, E7110-E7111). In an embodiment of the invention, a guide is modified to comprise a chemical moiety at its 3′ and/or 5′ end. Such moieties include, but are not limited to amine, azide, alkyne, thio, dibenzocyclooctyne (DBCO), or Rhodamine. In certain embodiment, the chemical moiety is conjugated to the guide by a linker, such as an alkyl chain. In certain embodiments, the chemical moiety of the modified guide can be used to attach the guide to another molecule, such as DNA, RNA, protein, or nanoparticles. Such chemically modified guide can be used to identify or enrich cells generically edited by a CRISPR system (see Lee et al., eLife, 2017, 6:e25312, DOI:10.7554).

In some embodiments, a nucleic acid-targeting guide is selected to reduce the degree secondary structure within the nucleic acid-targeting guide. In some embodiments, about or less than about 75%, 50%, 40%, 30%, 25%, 20%, 15%, 10%, 5%, 1%, or fewer of the nucleotides of the nucleic acid-targeting guide participate in self-complementary base pairing when optimally folded. Optimal folding may be determined by any suitable polynucleotide folding algorithm. Some programs are based on calculating the minimal Gibbs free energy. An example of one such algorithm is mFold, as described by Zuker and Stiegler (Nucleic Acids Res. 9 (1981), 133-148). Another example folding algorithm is the online webserver RNAfold, developed at Institute for Theoretical Chemistry at the University of Vienna, using the centroid structure prediction algorithm (see e.g., A. R. Gruber et al., 2008, Cell 106(1): 23-24; and PA Carr and GM Church, 2009, Nature Biotechnology 27(12): 1151-62).

In some embodiments, a nucleic acid-targeting guide is designed or selected to modulate intermolecular interactions among guide molecules, such as among stem-loop regions of different guide molecules. It will be appreciated that nucleotides within a guide that base-pair to form a stem-loop are also capable of base-pairing to form an intermolecular duplex with a second guide and that such an intermolecular duplex would not have a secondary structure compatible with CRISPR complex formation. Accordingly, is useful to select or design DR sequences in order to modulate stem-loop formation and CRISPR complex formation. In some embodiments, about or less than about 75%, 50%, 40%, 30%, 25%, 20%, 15%, 10%, 5%, 1%, or fewer of nucleic acid-targeting guides are in intermolecular duplexes. It will be appreciated that stem-loop variation will often be within limits imposed by DR-CRISPR effector interactions. One way to modulate stem-loop formation or change the equilibrium between stem-loop and intermolecular duplex is to vary nucleotide pairs in the stem of the stem-loop of a DR. For example, in one embodiment, a G-C pair is replaced by an A-U or U-A pair. In another embodiment, an A-U pair is substituted for a G-C or a C-G pair. In another embodiment, a naturally occurring nucleotide is replaced by a nucleotide analog. Another way to modulate stem-loop formation or change the equilibrium between stem-loop and intermolecular duplex is to modify the loop of the stem-loop of a DR. Without be bound by theory, the loop can be viewed as an intervening sequence flanked by two sequences that are complementary to each other. When that intervening sequence is not self-complementary, its effect will be to destabilize intermolecular duplex formation. The same principle applies when guides are multiplexed: while the targeting sequences may differ, it may be advantageous to modify the stem-loop region in the DRs of the different guides. Moreover, when guides are multiplexed, the relative activities of the different guides can be modulated by balancing the activity of each individual guide. In certain embodiments, the equilibrium between intermolecular stem-loops vs. intermolecular duplexes is determined. The determination may be made by physical or biochemical means and can be in the presence or absence of a CRISPR effector.

In certain embodiments, a guide RNA or crRNA may comprise, consist essentially of, or consist of a direct repeat (DR) sequence and a guide sequence or spacer sequence. In certain embodiments, the guide RNA or crRNA may comprise, consist essentially of, or consist of a direct repeat sequence fused or linked to a guide sequence or spacer sequence. In certain embodiments, the direct repeat sequence may be located upstream (i.e., 5′) from the guide sequence or spacer sequence. In other embodiments, the direct repeat sequence may be located downstream (i.e., 3′) from the guide sequence or spacer sequence.

In certain embodiments, the crRNA comprises a stem loop, preferably a single stem loop. In certain embodiments, the direct repeat sequence forms a stem loop, preferably a single stem loop.

In certain embodiments, the spacer length of the guide RNA is from 15 to 35 nt. In certain embodiments, the spacer length of the guide RNA is at least 15 nucleotides. In certain embodiments, the spacer length is from 15 to 17 nt, e.g., 15, 16, or 17 nt, from 17 to 20 nt, e.g., 17, 18, 19, or 20 nt, from 20 to 24 nt, e.g., 20, 21, 22, 23, or 24 nt, from 23 to 25 nt, e.g., 23, 24, or 25 nt, from 24 to 27 nt, e.g., 24, 25, 26, or 27 nt, from 27-30 nt, e.g., 27, 28, 29, or 30 nt, from 30-35 nt, e.g., 30, 31, 32, 33, 34, or 35 nt, or 35 nt or longer.

In general, the CRISPR-Cas, CRISPR-Cas9 or CRISPR system may be as used in the foregoing documents, such as WO 2014/093622 (PCT/US2013/074667) and refers collectively to transcripts and other elements involved in the expression of or directing the activity of CRISPR-associated (“Cas”) genes, including sequences encoding a Cas gene, in particular a Cas9 gene in the case of CRISPR-Cas9, a tracr (trans-activating CRISPR) sequence (e.g. tracrRNA or an active partial tracrRNA), a tracr-mate sequence (encompassing a “direct repeat” and a tracrRNA-processed partial direct repeat in the context of an endogenous CRISPR system), a guide sequence (also referred to as a “spacer” in the context of an endogenous CRISPR system), or “RNA(s)” as that term is herein used (e.g., RNA(s) to guide Cas9, e.g. CRISPR RNA and transactivating (tracr) RNA or a single guide RNA (sgRNA) (chimeric RNA)) or other sequences and transcripts from a CRISPR locus. In general, a CRISPR system is characterized by elements that promote the formation of a CRISPR complex at the site of a target sequence (also referred to as a protospacer in the context of an endogenous CRISPR system). In the context of formation of a CRISPR complex, “target sequence” refers to a sequence to which a guide sequence is designed to have complementarity, where hybridization between a target sequence and a guide sequence promotes the formation of a CRISPR complex. The section of the guide sequence through which complementarity to the target sequence is important for cleavage activity is referred to herein as the seed sequence. A target sequence may comprise any polynucleotide, such as DNA or RNA polynucleotides. In some embodiments, a target sequence is located in the nucleus or cytoplasm of a cell, and may include nucleic acids in or from mitochondrial, organelles, vesicles, liposomes or particles present within the cell. In some embodiments, especially for non-nuclear uses, NLSs are not preferred. In some embodiments, a CRISPR system comprises one or more nuclear exports signals (NESs). In some embodiments, a CRISPR system comprises one or more NLSs and one or more NESs. In some embodiments, direct repeats may be identified in silico by searching for repetitive motifs that fulfill any or all of the following criteria: 1. found in a 2Kb window of genomic sequence flanking the type II CRISPR locus; 2. span from 20 to 50 bp; and 3. interspaced by 20 to 50 bp. In some embodiments, 2 of these criteria may be used, for instance 1 and 2, 2 and 3, or 1 and 3. In some embodiments, all 3 criteria may be used.

In embodiments of the invention the terms guide sequence and guide RNA, i.e. RNA capable of guiding Cas to a target genomic locus, are used interchangeably as in foregoing cited documents such as WO 2014/093622 (PCT/US2013/074667). In general, a guide sequence is any polynucleotide sequence having sufficient complementarity with a target polynucleotide sequence to hybridize with the target sequence and direct sequence-specific binding of a CRISPR complex to the target sequence. In some embodiments, the degree of complementarity between a guide sequence and its corresponding target sequence, when optimally aligned using a suitable alignment algorithm, is about or more than about 50%, 60%, 75%, 80%, 85%, 90%, 95%, 97.5%, 99%, or more. Optimal alignment may be determined with the use of any suitable algorithm for aligning sequences, non-limiting example of which include the Smith-Waterman algorithm, the Needleman-Wunsch algorithm, algorithms based on the Burrows-Wheeler Transform (e.g. the Burrows Wheeler Aligner), ClustalW, Clustal X, BLAT, Novoalign (Novocraft Technologies; available at www.novocraft.com), ELAND (Illumina, San Diego, Calif.), SOAP (available at soap.genomics.org.cn), and Maq (available at maq.sourceforge.net). In some embodiments, a guide sequence is about or more than about 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 75, or more nucleotides in length. In some embodiments, a guide sequence is less than about 75, 50, 45, 40, 35, 30, 25, 20, 15, 12, or fewer nucleotides in length. Preferably the guide sequence is 10-30 nucleotides long. The ability of a guide sequence to direct sequence-specific binding of a CRISPR complex to a target sequence may be assessed by any suitable assay. For example, the components of a CRISPR system sufficient to form a CRISPR complex, including the guide sequence to be tested, may be provided to a host cell having the corresponding target sequence, such as by transfection with vectors encoding the components of the CRISPR sequence, followed by an assessment of preferential cleavage within the target sequence, such as by Surveyor assay as described herein. Similarly, cleavage of a target polynucleotide sequence may be evaluated in a test tube by providing the target sequence, components of a CRISPR complex, including the guide sequence to be tested and a control guide sequence different from the test guide sequence, and comparing binding or rate of cleavage at the target sequence between the test and control guide sequence reactions. Other assays are possible, and will occur to those skilled in the art.

In some embodiments of CRISPR-Cas systems, the degree of complementarity between a guide sequence and its corresponding target sequence can be about or more than about 50%, 60%, 75%, 80%, 85%, 90%, 95%, 97.5%, 99%, or 100%; a guide or RNA or sgRNA can be about or more than about 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 75, or more nucleotides in length; or guide or RNA or sgRNA can be less than about 75, 50, 45, 40, 35, 30, 25, 20, 15, 12, or fewer nucleotides in length; and advantageously tracr RNA is 30 or 50 nucleotides in length. However, an aspect of the invention is to reduce off-target interactions, e.g., reduce the guide interacting with a target sequence having low complementarity. Indeed, in the examples, it is shown that the invention involves mutations that result in the CRISPR-Cas system being able to distinguish between target and off-target sequences that have greater than 80% to about 95% complementarity, e.g., 83%-84% or 88-89% or 94-95% complementarity (for instance, distinguishing between a target having 18 nucleotides from an off-target of 18 nucleotides having 1, 2 or 3 mismatches). Accordingly, in the context of the present invention the degree of complementarity between a guide sequence and its corresponding target sequence is greater than 94.5% or 95% or 95.5% or 96% or 96.5% or 97% or 97.5% or 98% or 98.5% or 99% or 99.5% or 99.9%, or 100%. Off target is less than 100% or 99.9% or 99.5% or 99% or 99% or 98.5% or 98% or 97.5% or 97% or 96.5% or 96% or 95.5% or 95% or 94.5% or 94% or 93% or 92% or 91% or 90% or 89% or 88% or 87% or 86% or 85% or 84% or 83% or 82% or 81% or 80% complementarity between the sequence and the guide, with it advantageous that off target is 100% or 99.9% or 99.5% or 99% or 99% or 98.5% or 98% or 97.5% or 97% or 96.5% or 96% or 95.5% or 95% or 94.5% complementarity between the sequence and the guide.

Multiplexing Polynucleotides

Provided herein are engineered polynucleotide sequences that can direct the activity of a CRISPR protein to multiple targets using a single crRNA. The engineered polynucleotide sequences, also referred to as a multiplexing polynucleotides, can include two or more direct repeats interspersed with two or more guide sequences. More specifically, the engineered polynucleotide sequences can include a direct repeat sequence having one or more mutations relative to the corresponding wild type direct repeat sequence. The engineered polynucleotide can be configured, for example, as: 5′ DR1-G1-DR2-G2 3′. In some embodiments, the engineered polynucleotide can be configured to include three, four, five, or more additional direct repeat and guide sequences, for example: 5′ DR1-G1-DR2-G2-DR3-G3 3′, 5″ DR1-G1-DR2-G2-DR3-G3-DR4-G4 3′, or 5′ DR1-G1-DR2-G2-DR3-G3-DR4-G4-DR5-G5 3′.

Regardless of the number of direct repeat sequences, the direct repeat sequences differ from one another. Thus, DR1 can be a wild type sequence and DR2 can include one or more mutations relative to the wild type sequence in accordance with the disclosure provided herein regarding direct repeats for Cas orthologs. The guide sequences can also be the same or different. In some embodiments, the guide sequences can bind to different nucleic acid targets, for example, nucleic acids encoding different polypeptides. The multiplexing polynucleotides can be as described, for example, at [0039]-[0072] in U.S. Application 62/780,748 entitled “CRISPR Cpf1 Direct Repeat Variants” and filed Dec. 17, 2018, incorporated herein in its entirety by reference.

Multiplex design of guide molecules for the detection of coronaviruses and/or other respiratory viruses in a sample to identify the cause of a respiratory infection is envisioned, and design can be according to the methods disclosed herein. Briefly, the design of guide molecules can encompass utilization of training models described herein using a variety of input features, which may include the particular Cas protein used for targeting of the sequences of interest. See U.S. Provisional Application 62/818,702 FIG. 4A, incorporated specifically by reference. Guide molecules can be designed as detailed elsewhere herein. Regarding detection of coronavirus, guide design can be predicated on genome sequences disclosed in Tian et al, “Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody”; doi: 10.1101/2020.01.28.923011, incorporated by reference, which details human monoclonal antibody, CR3022 binding of the 2019-nCoV RBD (KD of 6.3 nM) or Sequences of the 2019-nCoV are available at GISAID accession no. EPI_ISL 402124 and EPI_ISL 402127-402130, and described in doi:10.1101/2020.01.22.914952, or EP_ISL 402119-402121 and EP_ISL 402123-402124; see also GenBank Accession No. MN908947.3. Guide design can target unique viral genomic regions of SARS-CoV-2 or conserved genomic regions across one or more viruses of the coronavirus family.

Guide Modifications

In certain embodiments, guides of the invention comprise non-naturally occurring nucleic acids and/or non-naturally occurring nucleotides and/or nucleotide analogs, and/or chemical modifications. Non-naturally occurring nucleic acids can include, for example, mixtures of naturally and non-naturally occurring nucleotides. Non-naturally occurring nucleotides and/or nucleotide analogs may be modified at the ribose, phosphate, and/or base moiety. In an embodiment of the invention, a guide nucleic acid comprises ribonucleotides and non-ribonucleotides. In one such embodiment, a guide comprises one or more ribonucleotides and one or more deoxyribonucleotides. In an embodiment of the invention, the guide comprises one or more non-naturally occurring nucleotide or nucleotide analog such as a nucleotide with phosphorothioate linkage, boranophosphate linkage, a locked nucleic acid (LNA) nucleotides comprising a methylene bridge between the 2′ and 4′ carbons of the ribose ring, or bridged nucleic acids (BNA). Other examples of modified nucleotides include 2′-O-methyl analogs, 2′-deoxy analogs, 2-thiouridine analogs, N6-methyladenosine analogs, or 2′-fluoro analogs. Further examples of modified bases include, but are not limited to, 2-aminopurine, 5-bromo-uridine, pseudouridine (Ψ), N1-methylpseudouridine (me1Ψ), 5-methoxyuridine(5moU), inosine, 7-methylguanosine. Examples of guide RNA chemical modifications include, without limitation, incorporation of 2′-O-methyl (M), 2′-O-methyl-3′-phosphorothioate (MS), phosphorothioate (PS), S-constrained ethyl(cEt), or 2′-O-methyl-3′-thioPACE (MSP) at one or more terminal nucleotides. Such chemically modified guides can comprise increased stability and increased activity as compared to unmodified guides, though on-target vs. off-target specificity is not predictable. (See, Hendel, 2015, Nat Biotechnol. 33(9):985-9, doi: 10.1038/nbt.3290, published online 29 Jun. 2015; Ragdarm et al., 0215, PNAS, E7110-E7111; Allerson et al., J. Med. Chem. 2005, 48:901-904; Bramsen et al., Front. Genet., 2012, 3:154; Deng et al., PNAS, 2015, 112:11870-11875; Sharma et al., MedChemComm., 2014, 5:1454-1471; Hendel et al., Nat. Biotechnol. (2015) 33(9): 985-989; Li et al., Nature Biomedical Engineering, 2017, 1, 0066 DOI:10.1038/s41551-017-0066). In some embodiments, the 5′ and/or 3′ end of a guide RNA is modified by a variety of functional moieties including fluorescent dyes, polyethylene glycol, cholesterol, proteins, or detection tags. (See Kelly et al., 2016, J. Biotech. 233:74-83). In certain embodiments, a guide comprises ribonucleotides in a region that binds to a target DNA and one or more deoxyribonucleotides and/or nucleotide analogs in a region that binds to Cas9, Cpf1, or C2c1. In an embodiment of the invention, deoxyribonucleotides and/or nucleotide analogs are incorporated in engineered guide structures, such as, without limitation, 5′ and/or 3′ end, stem-loop regions, and the seed region. In certain embodiments, the modification is not in the 5′-handle of the stem-loop regions. Chemical modification in the 5′-handle of the stem-loop region of a guide may abolish its function (see Li, et al., Nature Biomedical Engineering, 2017, 1:0066). In certain embodiments, at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, or 75 nucleotides of a guide is chemically modified. In some embodiments, 3-5 nucleotides at either the 3′ or the 5′ end of a guide is chemically modified. In some embodiments, only minor modifications are introduced in the seed region, such as 2′-F modifications. In some embodiments, 2′-F modification is introduced at the 3′ end of a guide. In certain embodiments, three to five nucleotides at the 5′ and/or the 3′ end of the guide are chemically modified with 2′-O-methyl (M), 2′-O-methyl-3′-phosphorothioate (MS), S-constrained ethyl(cEt), or 2′-O-methyl-3′-thioPACE (MSP). Such modification can enhance genome editing efficiency (see Hendel et al., Nat. Biotechnol. (2015) 33(9): 985-989). In certain embodiments, all of the phosphodiester bonds of a guide are substituted with phosphorothioates (PS) for enhancing levels of gene disruption. In certain embodiments, more than five nucleotides at the 5′ and/or the 3′ end of the guide are chemically modified with 2′-O-Me, 2′-F or S-constrained ethyl(cEt). Such chemically modified guide can mediate enhanced levels of gene disruption (see Ragdarm et al., 0215, PNAS, E7110-E7111). In an embodiment of the invention, a guide is modified to comprise a chemical moiety at its 3′ and/or 5′ end. Such moieties include, but are not limited to amine, azide, alkyne, thio, dibenzocyclooctyne (DBCO), or Rhodamine. In certain embodiment, the chemical moiety is conjugated to the guide by a linker, such as an alkyl chain. In certain embodiments, the chemical moiety of the modified guide can be used to attach the guide to another molecule, such as DNA, RNA, protein, or nanoparticles. Such chemically modified guide can be used to identify or enrich cells generically edited by a CRISPR system (see Lee et al., eLife, 2017, 6:e25312, DOI:10.7554).

In certain embodiments, the CRISPR system as provided herein can make use of a crRNA or analogous polynucleotide comprising a guide sequence, wherein the polynucleotide is an RNA, a DNA or a mixture of RNA and DNA, and/or wherein the polynucleotide comprises one or more nucleotide analogs. The sequence can comprise any structure, including but not limited to a structure of a native crRNA, such as a bulge, a hairpin or a stem loop structure. In certain embodiments, the polynucleotide comprising the guide sequence forms a duplex with a second polynucleotide sequence which can be an RNA or a DNA sequence.

In certain embodiments, use is made of chemically modified guide RNAs. Examples of guide RNA chemical modifications include, without limitation, incorporation of 2′-O-methyl (M), 2′-O-methyl 3′phosphorothioate (MS), or 2′-O-methyl 3′thioPACE (MSP) at one or more terminal nucleotides. Such chemically modified guide RNAs can comprise increased stability and increased activity as compared to unmodified guide RNAs, though on-target vs. off-target specificity is not predictable. (See, Hendel, 2015, Nat Biotechnol. 33(9):985-9, doi: 10.1038/nbt.3290, published online 29 Jun. 2015). Chemically modified guide RNAs further include, without limitation, RNAs with phosphorothioate linkages and locked nucleic acid (LNA) nucleotides comprising a methylene bridge between the 2′ and 4′ carbons of the ribose ring.

In some embodiments, a guide sequence is about or more than about 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 75, or more nucleotides in length. In some embodiments, a guide sequence is less than about 75, 50, 45, 40, 35, 30, 25, 20, 15, 12, or fewer nucleotides in length. Preferably the guide sequence is 10 to 30 nucleotides long. The ability of a guide sequence to direct sequence-specific binding of a CRISPR complex to a target sequence may be assessed by any suitable assay. For example, the components of a CRISPR system sufficient to form a CRISPR complex, including the guide sequence to be tested, may be provided to a host cell having the corresponding target sequence, such as by transfection with vectors encoding the components of the CRISPR sequence, followed by an assessment of preferential cleavage within the target sequence, such as by Surveyor assay. Similarly, cleavage of a target RNA may be evaluated in a test tube by providing the target sequence, components of a CRISPR complex, including the guide sequence to be tested and a control guide sequence different from the test guide sequence, and comparing binding or rate of cleavage at the target sequence between the test and control guide sequence reactions. Other assays are possible, and will occur to those skilled in the art.

In some embodiments, the modification to the guide is a chemical modification, an insertion, a deletion or a split. In some embodiments, the chemical modification includes, but is not limited to, incorporation of 2′-O-methyl (M) analogs, 2′-deoxy analogs, 2-thiouridine analogs, N6-methyladenosine analogs, 2′-fluoro analogs, 2-aminopurine, 5-bromo-uridine, pseudouridine (Ψ), N1-methylpseudouridine (me1Ψ), 5-methoxyuridine(5moU), inosine, 7-methylguanosine, 2′-O-methyl-3′-phosphorothioate (MS), S-constrained ethyl(cEt), phosphorothioate (PS), or 2′-O-methyl-3′-thioPACE (MSP). In some embodiments, the guide comprises one or more of phosphorothioate modifications. In certain embodiments, at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 25 nucleotides of the guide are chemically modified. In certain embodiments, one or more nucleotides in the seed region are chemically modified. In certain embodiments, one or more nucleotides in the 3′-terminus are chemically modified. In certain embodiments, none of the nucleotides in the 5′-handle is chemically modified. In some embodiments, the chemical modification in the seed region is a minor modification, such as incorporation of a 2′-fluoro analog. In a specific embodiment, one nucleotide of the seed region is replaced with a 2′-fluoro analog. In some embodiments, 5 or 10 nucleotides in the 3′-terminus are chemically modified. Such chemical modifications at the 3′-terminus of the Cpf1 CrRNA improve gene cutting efficiency (see Li, et al., Nature Biomedical Engineering, 2017, 1:0066). In a specific embodiment, 5 nucleotides in the 3′-terminus are replaced with 2′-fluoro analogues. In a specific embodiment, 10 nucleotides in the 3′-terminus are replaced with 2′-fluoro analogues. In a specific embodiment, 5 nucleotides in the 3′-terminus are replaced with 2′-O-methyl (M) analogs.

In some embodiments, the loop of the 5′-handle of the guide is modified. In some embodiments, the loop of the 5′-handle of the guide is modified to have a deletion, an insertion, a split, or chemical modifications. In certain embodiments, the loop comprises 3, 4, or 5 nucleotides. In certain embodiments, the loop comprises the sequence of UCUU, UUUU, UAUU, or UGUU.

A guide sequence, and hence a nucleic acid-targeting guide RNA may be selected to target any target nucleic acid sequence. In the context of formation of a CRISPR complex, “target sequence” refers to a sequence to which a guide sequence is designed to have complementarity, where hybridization between a target sequence and a guide sequence promotes the formation of a CRISPR complex. A target sequence may comprise RNA polynucleotides. The term “target RNA” refers to a RNA polynucleotide being or comprising the target sequence. In other words, the target RNA may be a RNA polynucleotide or a part of a RNA polynucleotide to which a part of the gRNA, i.e. the guide sequence, is designed to have complementarity and to which the effector function mediated by the complex comprising CRISPR effector protein and a gRNA is to be directed. In some embodiments, a target sequence is located in the nucleus or cytoplasm of a cell. The target sequence may be DNA. The target sequence may be any RNA sequence. In some embodiments, the target sequence may be a sequence within a RNA molecule selected from the group consisting of messenger RNA (mRNA), pre-mRNA, ribosomal RNA (rRNA), transfer RNA (tRNA), micro-RNA (miRNA), small interfering RNA (siRNA), small nuclear RNA (snRNA), small nuclear RNA (snoRNA), double stranded RNA (dsRNA), non coding RNA (ncRNA), long non-coding RNA (lncRNA), and small cytoplasmic RNA (scRNA). In some preferred embodiments, the target sequence may be a sequence within a RNA molecule selected from the group consisting of mRNA, pre-mRNA, and rRNA. In some preferred embodiments, the target sequence may be a sequence within a RNA molecule selected from the group consisting of ncRNA, and lncRNA. In some more preferred embodiments, the target sequence may be a sequence within an mRNA molecule or a pre-mRNA molecule.

In certain embodiments, the spacer length of the guide RNA is less than 28 nucleotides. In certain embodiments, the spacer length of the guide RNA is at least 18 nucleotides and less than 28 nucleotides. In certain embodiments, the spacer length of the guide RNA is between 19 and 28 nucleotides. In certain embodiments, the spacer length of the guide RNA is between 19 and 25 nucleotides. In certain embodiments, the spacer length of the guide RNA is 20 nucleotides. In certain embodiments, the spacer length of the guide RNA is 23 nucleotides. In certain embodiments, the spacer length of the guide RNA is 25 nucleotides.

In certain embodiments, modulations of cleavage efficiency can be exploited by introduction of mismatches, e.g. 1 or more mismatches, such as 1 or 2 mismatches between spacer sequence and target sequence, including the position of the mismatch along the spacer/target. The more central (i.e. not 3′ or 5′) for instance a double mismatch is, the more cleavage efficiency is affected. Accordingly, by choosing mismatch position along the spacer, cleavage efficiency can be modulated. By means of example, if less than 100% cleavage of targets is desired (e.g. in a cell population), 1 or more, such as preferably 2 mismatches between spacer and target sequence may be introduced in the spacer sequences. The more central along the spacer of the mismatch position, the lower the cleavage percentage.

In certain example embodiments, the cleavage efficiency may be exploited to design single guides that can distinguish two or more targets that vary by a single nucleotide, such as a single nucleotide polymorphism (SNP), variation, or (point) mutation. The CRISPR effector may have reduced sensitivity to SNPs (or other single nucleotide variations) and continue to cleave SNP targets with a certain level of efficiency. Thus, for two targets, or a set of targets, a guide RNA may be designed with a nucleotide sequence that is complementary to one of the targets i.e. the on-target SNP. The guide RNA is further designed to have a synthetic mismatch. As used herein a “synthetic mismatch” refers to a non-naturally occurring mismatch that is introduced upstream or downstream of the naturally occurring SNP, such as at most 5 nucleotides upstream or downstream, for instance 4, 3, 2, or 1 nucleotide upstream or downstream, preferably at most 3 nucleotides upstream or downstream, more preferably at most 2 nucleotides upstream or downstream, most preferably 1 nucleotide upstream or downstream (i.e. adjacent the SNP). When the CRISPR effector binds to the on-target SNP, only a single mismatch will be formed with the synthetic mismatch and the CRISPR effector will continue to be activated and a detectable signal produced. When the guide RNA hybridizes to an off-target SNP, two mismatches will be formed, the mismatch from the SNP and the synthetic mismatch, and no detectable signal generated. Thus, the systems disclosed herein may be designed to distinguish SNPs within a population. For, example the systems may be used to distinguish pathogenic strains that differ by a single SNP or detect certain disease specific SNPs, such as but not limited to, disease associated SNPs, such as without limitation cancer associated SNPs.

In certain embodiments, the guide RNA is designed such that the SNP is located on position 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 of the spacer sequence (starting at the 5′ end). In certain embodiments, the guide RNA is designed such that the SNP is located on position 1, 2, 3, 4, 5, 6, 7, 8, or 9 of the spacer sequence (starting at the 5′ end). In certain embodiments, the guide RNA is designed such that the SNP is located on position 2, 3, 4, 5, 6, or 7 of the spacer sequence (starting at the 5′ end). In certain embodiments, the guide RNA is designed such that the SNP is located on position 3, 4, 5, or 6 of the spacer sequence (starting at the 5′ end). In certain embodiments, the guide RNA is designed such that the SNP is located on position 3 of the spacer sequence (starting at the 5′ end).

In certain embodiments, the guide RNA is designed such that the mismatch (e.g. the synthetic mismatch, i.e. an additional mutation besides a SNP) is located on position 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 of the spacer sequence (starting at the 5′ end). In certain embodiments, the guide RNA is designed such that the mismatch is located on position 1, 2, 3, 4, 5, 6, 7, 8, or 9 of the spacer sequence (starting at the 5′ end). In certain embodiments, the guide RNA is designed such that the mismatch is located on position 4, 5, 6, or 7 of the spacer sequence (starting at the 5′ end. In certain embodiments, the guide RNA is designed such that the mismatch is located at position 3, 4, 5, or 6 of the spacer, preferably position 3. In certain embodiments, the guide RNA is designed such that the mismatch is located on position 5 of the spacer sequence (starting at the 5′ end).

In certain embodiments, said mismatch is 1, 2, 3, 4, or 5 nucleotides upstream or downstream, preferably 2 nucleotides, preferably downstream of said SNP or other single nucleotide variation in said guide RNA.

In certain embodiments, the guide RNA is designed such that the mismatch is located 2 nucleotides upstream of the SNP (i.e. one intervening nucleotide).

In certain embodiments, the guide RNA is designed such that the mismatch is located 2 nucleotides downstream of the SNP (i.e. one intervening nucleotide).

In certain embodiments, the guide RNA is designed such that the mismatch is located on position 5 of the spacer sequence (starting at the 5′ end) and the SNP is located on position 3 of the spacer sequence (starting at the 5′ end).

In certain embodiments, the guide RNA comprises a spacer which is truncated relative to a wild type spacer. In certain embodiments, the guide RNA comprises a spacer which comprises less than 28 nucleotides, preferably between and including 20 to 27 nucleotides.

In certain embodiments, the guide RNA comprises a spacer which consists of 20-25 nucleotides or 20-23 nucleotides, such as preferably 20 or 23 nucleotides.

In certain embodiments, the one or more guide RNAs are designed to detect a single nucleotide polymorphism in a target RNA or DNA, or a splice variant of an RNA transcript.

In certain embodiments, the one or more guide RNAs may be designed to bind to one or more target molecules that are diagnostic for a disease state. In some embodiments, the disease may be cancer. In some embodiments, the disease state may be an autoimmune disease. In some embodiments, the disease state may be an infection. In some embodiments, the infection may be caused by a virus, a bacterium, a fungus, a protozoa, or a parasite. In specific embodiments, the infection is a viral infection. In specific embodiments, the viral infection is caused by a DNA virus.

The embodiments described herein comprehend inducing one or more nucleotide modifications in a eukaryotic cell (in vitro, i.e. in an isolated eukaryotic cell) as herein discussed comprising delivering to cell a vector as herein discussed. The mutation(s) can include the introduction, deletion, or substitution of one or more nucleotides at each target sequence of cell(s) via the guide(s) RNA(s). The mutations can include the introduction, deletion, or substitution of 1-75 nucleotides at each target sequence of said cell(s) via the guide(s) RNA(s). The mutations can include the introduction, deletion, or substitution of 1, 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, or 75 nucleotides at each target sequence of said cell(s) via the guide(s) RNA(s). The mutations can include the introduction, deletion, or substitution of 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, or 75 nucleotides at each target sequence of said cell(s) via the guide(s) RNA(s). The mutations include the introduction, deletion, or substitution of 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, or 75 nucleotides at each target sequence of said cell(s) via the guide(s) RNA(s). The mutations can include the introduction, deletion, or substitution of 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, or 75 nucleotides at each target sequence of said cell(s) via the guide(s) RNA(s). The mutations can include the introduction, deletion, or substitution of 40, 45, 50, 75, 100, 200, 300, 400 or 500 nucleotides at each target sequence of said cell(s) via the guide(s) RNA(s).

Typically, in the context of an endogenous CRISPR system, formation of a CRISPR complex (comprising a guide sequence hybridized to a target sequence and complexed with one or more Cas proteins) results in cleavage in or near (e.g. within 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 50, or more base pairs from) the target sequence, but may depend on for instance secondary structure, in particular in the case of RNA targets.

Methods for Designing Highly Active Guides

A method for designing highly active guide molecules, e.g., guide RNAs, for use in the detection systems may comprise the steps of designing putative guide RNAs tiled across a target molecule of interest; creating a training model based on results of incubating guide RNAs with a Cas13 protein and the target molecule; predicting highly active guide RNAs for the target molecule, wherein the predicting comprises optimizing the nucleotide at each base position in the guide RNA based on the training model; and validating the predicted highly active guide RNAs by incubating the guide RNAs with the Cas13 protein and the target molecule. The method can be as described in U.S. Provisional Application Nos. 62/818,702 amd 62/890,555 (Attorney Reference BI-10504, Docket BROD-3980) incorporated by reference in their entirety. Guide RNAs generate by the design methods can be used with the systems for detecting coronavirus as described elsewhere herein.

In some embodiments, the invention provides a method for designing guide RNAs for use in the detection systems described herein. The method may comprise designing putative guide RNAs tiled across a target molecule of interest, such as a coronavirus, viruses that cause respiratory illness, including coronavirus, including 2019-nCov (Covid-19). The method may further comprise creating a training model based on results of incubating guide RNAs with a Cas13 protein and the target molecule. The method may further comprise predicting highly active guide RNAs for the target molecule. Predicting may comprise optimizing the nucleotide at each base position in the guide RNA based on the training model. The method may further comprise validating the predicted highly active guide RNAs by incubating the guide RNAs with the Cas13 protein and the target molecule.

In certain instances, the optimized guide for the target molecule is generated by pooling a set of guides, the guides produced by tiling guides across the target molecule; incubating the set of guides with a Cas polypeptide and the target molecule and measuring cleavage activity of each guide in the set; creating a training model based on the cleavage activity of the set of guides in the incubating step. Steps of predicting highly active guides for the target molecule and identifying the optimized guides by incubating the predicted highly active guides with the Cas polypeptide and the target molecule and selecting optimized guides may also be utilized in generating optimized guides. In embodiments, the training model comprises one or more input features selected from guide sequence, flanking target sequence, normalized positions of the guide in the target and guide GC content. In certain instances, the guide sequence and/or flanking sequence input comprises one hit encoding mono-nucleotide and/or dinucleotide In an embodiments, the training model comprises applying logistic regression model on the activity of the guides across the one or more input features.

In an aspect, the predicting highly active guides for the target molecule comprises selecting guides with an increase in activity of a guide relative to the median activity, or selecting guides with highest guide activity. In certain instances, the increase in activity is measured by an increase in fluorescence. Guides may be selected based on a particular cutoff, in certain instances based on activity relative to a median or above a particular cutoff-, for instance, are selected with a 1.5, 2, 2.5 or 3-fold activity relative to median, or are in the top quartile or quintile for each target tested.

The optimized guides may be generated for a Cas13 ortholog, in some instances, the optimized guide is generated for an LwaCas13a or a Cca13b ortholog.

In some embodiments, the invention provides a method for designing guide RNAs for use in the detection systems described herein. The method may comprise designing putative guide RNAs tiled across a target molecule of interest. The method may further comprise creating a training model based on results of incubating guide RNAs with a Cas13 protein and the target molecule. The method may further comprise predicting highly active guide RNAs for the target molecule. Predicting may comprise optimizing the nucleotide at each base position in the guide RNA based on the training model. The method may further comprise validating the predicted highly active guide RNAs by incubating the guide RNAs with the Cas13 protein and the target molecule.

Guides may be screened for on-target and off-target effects. When using LAMP amplification, the products of LAMP can help identify those guides with more minimal off-target effects relative to on-target products.

The design of putative guide RNAs for target molecules of interest is described elsewhere herein.

The creation of training models is known in the art. Machine learning can be generalized as the ability of a learning machine to perform accurately on new, unseen examples/tasks after having experienced a learning data set. Machine learning may include the following concepts and methods. Supervised learning concepts may include AODE; Artificial neural network, such as Backpropagation, Autoencoders, Hopfield networks, Boltzmann machines, Restricted Boltzmann Machines, and Spiking neural networks; Bayesian statistics, such as Bayesian network and Bayesian knowledge base; Case-based reasoning; Gaussian process regression; Gene expression programming; Group method of data handling (GMDH); Inductive logic programming; Instance-based learning; Lazy learning; Learning Automata; Learning Vector Quantization; Logistic Model Tree; Minimum message length (decision trees, decision graphs, etc.), such as Nearest Neighbor Algorithm and Analogical modeling; Probably approximately correct learning (PAC) learning; Ripple down rules, a knowledge acquisition methodology; Symbolic machine learning algorithms; Support vector machines; Random Forests; Ensembles of classifiers, such as Bootstrap aggregating (bagging) and Boosting (meta-algorithm); Ordinal classification; Information fuzzy networks (IFN); Conditional Random Field; ANOVA; Linear classifiers, such as Fisher's linear discriminant, Linear regression, Logistic regression, Multinomial logistic regression, Naive Bayes classifier, Perceptron, Support vector machines; Quadratic classifiers; k-nearest neighbor; Boosting; Decision trees, such as C4.5, Random forests, ID3, CART, SLIQ, SPRINT; Bayesian networks, such as Naive Bayes; and Hidden Markov models. Unsupervised learning concepts may include; Expectation-maximization algorithm; Vector Quantization; Generative topographic map; Information bottleneck method; Artificial neural network, such as Self-organizing map; Association rule learning, such as, Apriori algorithm, Eclat algorithm, and FP-growth algorithm; Hierarchical clustering, such as Single-linkage clustering and Conceptual clustering; Cluster analysis, such as, K-means algorithm, Fuzzy clustering, DBSCAN, and OPTICS algorithm; and Outlier Detection, such as Local Outlier Factor. Semi-supervised learning concepts may include; Generative models; Low-density separation; Graph-based methods; and Co-training. Reinforcement learning concepts may include; Temporal difference learning; Q-learning; Learning Automata; and SARSA. Deep learning concepts may include; Deep belief networks; Deep Boltzmann machines; Deep Convolutional neural networks; Deep Recurrent neural networks; and Hierarchical temporal memory.

The methods as disclosed herein designing putative guide RNAs may comprise design based on one or more variables, including guide sequence, flanking target sequence, guide position and guide GC content as input features. In certain embodiments, the length of the flanking target region can be considered a freeparameter and can be further selected during cross-validation. Additionally, mono-nucleotide and/or dinucleotide based identities across a guide length and flanking sequence in the target, varying one or more of flanking sequence length, normalized positions of the guide in the target, and GC content of the guide, or a combination thereof.

In embodiments, the training model for the guide design of highly active guides is Cas protein specific. In embodiments, the Cas protein is a Cas13a, Cas13b, a Cas12a and/or a Cas12b protein. In certain embodiments, the protein is LwaCas13a or CcaCas13b. Selection for the best guides can be dependent on each enzyme. In particular embodiments, where majority of guides have activity above background on a per-target basis, selection of guides may be based on 1.5 fold, 2, 2.5, 3 or more fold activity over the median activity. In other instances, the best performing guides may be at or near background fluorescence. In this instance, the guide selection may be based on a top percentile, e.g. quartile or quintile, of performing guides.

Codon optimization is described elsewhere herein. In specific embodiments, the nucleotide at each base position in the guide RNA may be optimized based on the training model, thus allowing for prediction of highly active guide RNAs for the target molecule.

The predicted highly active guide RNAs may then be validated or verified by incubating the guide RNAs with a Cas effector protein, such as Cas13 protein and the target molecule(s) for coronavirus, for example coronavirus sequence that is immunostimulatory to a host immune system, or a target sequence unique to the 2019-nCov, as described elsewhere herein.

In certain embodiments, optimization comprises validation of best performing models for a particular Cas polypeptide across multiple guides may comprise comparing the predicted score of each guide versus actual collateral activity upon target recognition. In embodiments, kinetic data of the best and worst predicted guides are evaluated. In embodiments, lateral flow performance of the predicted guides is evaluated for a target sequence.

In an aspect, the guide sequence is selected from SEQ ID NOS: 40,500-61,643. Guide sequences can also be selected from Table 5 or Table 10 or Table 16.

Detection Construct

The systems and methods described herein comprise a detection construct. As used herein, a “detection construct” refers to a molecule that can be cleaved or otherwise deactivated by an activated CRISPR system effector protein described herein. The term “detection construct” may also be referred to in the alternative as a “masking construct.” Depending on the nuclease activity of the CRISPR effector protein, the masking construct may be a RNA-based masking construct or a DNA-based masking construct. The Nucleic Acid-based masking constructs comprises a nucleic acid element that is cleavable by a CRISPR effector protein. Cleavage of the nucleic acid element releases agents or produces conformational changes that allow a detectable signal to be produced. Example constructs demonstrating how the nucleic acid element may be used to prevent or mask generation of detectable signal are described below and embodiments of the invention comprise variants of the same. Prior to cleavage, or when the masking construct is in an ‘active’ state, the masking construct blocks the generation or detection of a positive detectable signal. In certain embodiments, detection constructs are designed for cutting motifs of particular Cas proteins. See, International Publication WO 2019/126577, incorporated herein by reference in its entirety, and specifically paragraphs [00314]-[00356], Table 25, and Examples 8-10, for teaching of design of detection constructs for Cas proteins with preferred cutting motifs. For example, when AapCas12b is used, a reporter designed with A and T bases can be utilized because of preferred cleavage specificity. In an aspect, a reporter comprising sequence TTTTTTT is utilized with AapCas12b systems. In embodiments, the reporter comprises a AAAAA sequence or a TTTTT sequence. In an aspect, the reporter is selected from WCV328, WCV329, WCV333. The reporter can be selected from WCV0333/5HEX/TTTTTTT/3IABkFQ/homopolymer hex probe, WCV0328/5HEX/AAAAA/3IABkFQ/homopolymer hex probe, and WCV0329/5HEX/TTTTT/3IABkFQ/homopolymer hex probe.

It will be understood that in certain example embodiments a minimal background signal may be produced in the presence of an active masking construct. A positive detectable signal may be any signal that can be detected using optical, fluorescent, chemiluminescent, electrochemical or other detection methods known in the art. The term “positive detectable signal” is used to differentiate from other detectable signals that may be detectable in the presence of the masking construct. For example, in certain embodiments a first signal may be detected when the masking agent is present or when a CRISPR system has not been activated (i.e. a negative detectable signal), which then converts to a second signal (e.g. the positive detectable signal) upon detection of the target molecules and cleavage or deactivation of the masking agent, or upon activation of the CRISPR effector protein. The positive detectable signal, then, is a signal detected upon activation of the CRISPR effector protein, and may be, in a colorimetric or fluorescent assay, a decrease in fluorescence or color relative to a control or an increase in fluorescence or color relative to a control, depending on the configuration of the lateral flow substrate, and as described further herein.

In certain example embodiments, the masking construct may comprise a HCR initiator sequence and a cutting motif, or a cleavable structural element, such as a loop or hairpin, that prevents the initiator from initiating the HCR reaction. The cutting motif may be preferentially cut by one of the activated CRISPR effector proteins. Upon cleavage of the cutting motif or structure element by an activated CRISPR effector protein, the initiator is then released to trigger the HCR reaction, detection thereof indicating the presence of one or more targets in the sample. In certain example embodiments, the masking construct comprises a hairpin with a RNA loop. When an activated CRISPR effector protein cuts the RNA loop, the initiator can be released to trigger the HCR reaction.

In certain example embodiments, the masking construct may suppress generation of a gene product. The gene product may be encoded by a reporter construct that is added to the sample. The masking construct may be an interfering RNA involved in a RNA interference pathway, such as a short hairpin RNA (shRNA) or small interfering RNA (siRNA). The masking construct may also comprise microRNA (miRNA). While present, the masking construct suppresses expression of the gene product. The gene product may be a fluorescent protein or other RNA transcript or proteins that would otherwise be detectable by a labeled probe, aptamer, or antibody but for the presence of the masking construct. Upon activation of the effector protein the masking construct is cleaved or otherwise silenced allowing for expression and detection of the gene product as the positive detectable signal. In preferred embodiments, the masking constructs comprise two or more detectable signals, for example, fluorescent signals, that can be read on different channels of a fluorimeter.

In specific embodiments, the masking construct comprises a silencing RNA that suppresses generation of a gene product encoded by a reporting construct, wherein the gene product generates the detectable positive signal when expressed.

In certain example embodiments, the masking construct may sequester one or more reagents needed to generate a detectable positive signal such that release of the one or more reagents from the masking construct results in generation of the detectable positive signal. The one or more reagents may combine to produce a colorimetric signal, a chemiluminescent signal, a fluorescent signal, or any other detectable signal and may comprise any reagents known to be suitable for such purposes. In certain example embodiments, the one or more reagents are sequestered by RNA aptamers that bind the one or more reagents. The one or more reagents are released when the effector protein is activated upon detection of a target molecule and the RNA or DNA aptamers are degraded.

In certain example embodiments, the masking construct may be immobilized on a solid substrate in an individual discrete volume (defined further below) and sequesters a single reagent. For example, the reagent may be a bead comprising a dye. When sequestered by the immobilized reagent, the individual beads are too diffuse to generate a detectable signal, but upon release from the masking construct are able to generate a detectable signal, for example by aggregation or simple increase in solution concentration. In certain example embodiments, the immobilized masking agent is a RNA- or DNA-based aptamer that can be cleaved by the activated effector protein upon detection of a target molecule.

In certain other example embodiments, the masking construct binds to an immobilized reagent in solution thereby blocking the ability of the reagent to bind to a separate labeled binding partner that is free in solution. Thus, upon application of a washing step to a sample, the labeled binding partner can be washed out of the sample in the absence of a target molecule. However, if the effector protein is activated, the masking construct is cleaved to a degree sufficient to interfere with the ability of the masking construct to bind the reagent thereby allowing the labeled binding partner to bind to the immobilized reagent. Thus, the labeled binding partner remains after the wash step indicating the presence of the target molecule in the sample. In certain aspects, the masking construct that binds the immobilized reagent is a DNA or RNA aptamer. The immobilized reagent may be a protein and the labeled binding partner may be a labeled antibody. Alternatively, the immobilized reagent may be streptavidin and the labeled binding partner may be labeled biotin. The label on the binding partner used in the above embodiments may be any detectable label known in the art. In addition, other known binding partners may be used in accordance with the overall design described herein.

In certain example embodiments, the masking construct may comprise a ribozyme. Ribozymes are RNA molecules having catalytic properties. Ribozymes, both naturally and engineered, comprise or consist of RNA that may be targeted by the effector proteins disclosed herein. The ribozyme may be selected or engineered to catalyze a reaction that either generates a negative detectable signal or prevents generation of a positive control signal. Upon deactivation of the ribozyme by the activated effector protein the reaction generating a negative control signal, or preventing generation of a positive detectable signal, is removed thereby allowing a positive detectable signal to be generated. In one example embodiment, the ribozyme may catalyze a colorimetric reaction causing a solution to appear as a first color. When the ribozyme is deactivated the solution then turns to a second color, the second color being the detectable positive signal. An example of how ribozymes can be used to catalyze a colorimetric reaction are described in Zhao et al. “Signal amplification of glucosamine phosphate based on ribozyme glmS,” Biosens Bioelectron. 2014; 16:337-42, and provide an example of how such a system could be modified to work in the context of the embodiments disclosed herein. Alternatively, ribozymes, when present can generate cleavage products of, for example, RNA transcripts. Thus, detection of a positive detectable signal may comprise detection of non-cleaved RNA transcripts that are only generated in the absence of the ribozyme.

In some embodiments, the masking construct may be a ribozyme that generates a negative detectable signal, and wherein a positive detectable signal is generated when the ribozyme is deactivated.

In certain example embodiments, the one or more reagents is a protein, such as an enzyme, capable of facilitating generation of a detectable signal, such as a colorimetric, chemiluminescent, or fluorescent signal, that is inhibited or sequestered such that the protein cannot generate the detectable signal by the binding of one or more DNA or RNA aptamers to the protein. Upon activation of the effector proteins disclosed herein, the DNA or RNA aptamers are cleaved or degraded to an extent that they no longer inhibit the protein's ability to generate the detectable signal. In certain example embodiments, the aptamer is a thrombin inhibitor aptamer. In certain example embodiments the thrombin inhibitor aptamer has a sequence of GGGAACAAAGCUGAAGUACUUACCC (SEQ ID NO: 62012). When this aptamer is cleaved, thrombin will become active and will cleave a peptide colorimetric or fluorescent substrate. In certain example embodiments, the colorimetric substrate is para-nitroanilide (pNA) covalently linked to the peptide substrate for thrombin. Upon cleavage by thrombin, pNA is released and becomes yellow in color and easily visible to the eye. In certain example embodiments, the fluorescent substrate is 7-amino-4-methylcoumarin a blue fluorophore that can be detected using a fluorescence detector. Inhibitory aptamers may also be used for horseradish peroxidase (HRP), beta-galactosidase, or calf alkaline phosphatase (CAP) and within the general principals laid out above.

In certain embodiments, RNAse or DNAse activity is detected colorimetrically via cleavage of enzyme-inhibiting aptamers. One potential mode of converting DNAse or RNAse activity into a colorimetric signal is to couple the cleavage of a DNA or RNA aptamer with the re-activation of an enzyme that is capable of producing a colorimetric output. In the absence of RNA or DNA cleavage, the intact aptamer will bind to the enzyme target and inhibit its activity. The advantage of this readout system is that the enzyme provides an additional amplification step: once liberated from an aptamer via collateral activity (e.g. Cpf1 collateral activity), the colorimetric enzyme will continue to produce colorimetric product, leading to a multiplication of signal.

In certain embodiments, an existing aptamer that inhibits an enzyme with a colorimetric readout is used. Several aptamer/enzyme pairs with colorimetric readouts exist, such as thrombin, protein C, neutrophil elastase, and subtilisin. These proteases have colorimetric substrates based upon pNA and are commercially available. In certain embodiments, a novel aptamer targeting a common colorimetric enzyme is used. Common and robust enzymes, such as beta-galactosidase, horseradish peroxidase, or calf intestinal alkaline phosphatase, could be targeted by engineered aptamers designed by selection strategies such as SELEX. Such strategies allow for quick selection of aptamers with nanomolar binding efficiencies and could be used for the development of additional enzyme/aptamer pairs for colorimetric readout.

In certain embodiments, the masking construct may be a DNA or RNA aptamer and/or may comprise a DNA or RNA-tethered inhibitor.

In certain embodiments, the masking construct may comprise a DNA or RNA oligonucleotide to which a detectable ligand and a masking component are attached.

In certain embodiments, RNAse or DNase activity is detected colorimetrically via cleavage of RNA-tethered inhibitors. Many common colorimetric enzymes have competitive, reversible inhibitors: for example, beta-galactosidase can be inhibited by galactose. Many of these inhibitors are weak, but their effect can be increased by increases in local concentration. By linking local concentration of inhibitors to DNase RNAse activity, colorimetric enzyme and inhibitor pairs can be engineered into DNase and RNAse sensors. The colorimetric DNase or RNAse sensor based upon small-molecule inhibitors involves three components: the colorimetric enzyme, the inhibitor, and a bridging RNA or DNA that is covalently linked to both the inhibitor and enzyme, tethering the inhibitor to the enzyme. In the uncleaved configuration, the enzyme is inhibited by the increased local concentration of the small molecule; when the DNA or RNA is cleaved (e.g. by Cas13 or Cas12 collateral cleavage), the inhibitor will be released and the colorimetric enzyme will be activated.

In certain embodiments, the aptamer or DNA- or RNA-tethered inhibitor may sequester an enzyme, wherein the enzyme generates a detectable signal upon release from the aptamer or DNA or RNA tethered inhibitor by acting upon a substrate. In some embodiments, the aptamer may be an inhibitor aptamer that inhibits an enzyme and prevents the enzyme from catalyzing generation of a detectable signal from a substance. In some embodiments, the DNA- or RNA-tethered inhibitor may inhibit an enzyme and may prevent the enzyme from catalyzing generation of a detectable signal from a substrate.

In certain embodiments, RNAse activity is detected colorimetrically via formation and/or activation of G-quadruplexes. G quadruplexes in DNA can complex with heme (iron (III)-protoporphyrin IX) to form a DNAzyme with peroxidase activity. When supplied with a peroxidase substrate (e.g. ABTS: (2,2′-Azinobis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt)), the G-quadruplex-heme complex in the presence of hydrogen peroxide causes oxidation of the substrate, which then forms a green color in solution. An example G-quadruplex forming DNA sequence is: GGGTAGGGCGGGTTGGGA (SEQ ID NO: 62013). By hybridizing an additional DNA or RNA sequence, referred to herein as a “staple,” to this DNA aptamer, formation of the G-quadraplex structure will be limited. Upon collateral activation, the staple will be cleaved allowing the G quadraplex to form and heme to bind. This strategy is particularly appealing because color formation is enzymatic, meaning there is additional amplification beyond collateral activation.

In certain embodiments, the masking construct may comprise an RNA oligonucleotide designed to bind a G-quadruplex forming sequence, wherein a G-quadruplex structure is formed by the G-quadruplex forming sequence upon cleavage of the masking construct, and wherein the G-quadruplex structure generates a detectable positive signal.

In certain example embodiments, the masking construct may be immobilized on a solid substrate in an individual discrete volume (defined further below) and sequesters a single reagent. For example, the reagent may be a bead comprising a dye. When sequestered by the immobilized reagent, the individual beads are too diffuse to generate a detectable signal, but upon release from the masking construct are able to generate a detectable signal, for example by aggregation or simple increase in solution concentration. In certain example embodiments, the immobilized masking agent is a DNA- or RNA-based aptamer that can be cleaved by the activated effector protein upon detection of a target molecule.

In one example embodiment, the masking construct comprises a detection agent that changes color depending on whether the detection agent is aggregated or dispersed in solution. For example, certain nanoparticles, such as colloidal gold, undergo a visible purple to red color shift as they move from aggregates to dispersed particles. Accordingly, in certain example embodiments, such detection agents may be held in aggregate by one or more bridge molecules. At least a portion of the bridge molecule comprises RNA or DNA. Upon activation of the effector proteins disclosed herein, the RNA or DNA portion of the bridge molecule is cleaved allowing the detection agent to disperse and resulting in the corresponding change in color. In certain example embodiments, the detection agent is a colloidal metal. The colloidal metal material may include water-insoluble metal particles or metallic compounds dispersed in a liquid, a hydrosol, or a metal sol. The colloidal metal may be selected from the metals in groups IA, IB, IIB and IIIB of the periodic table, as well as the transition metals, especially those of group VIII. Preferred metals include gold, silver, aluminum, ruthenium, zinc, iron, nickel and calcium. Other suitable metals also include the following in all of their various oxidation states: lithium, sodium, magnesium, potassium, scandium, titanium, vanadium, chromium, manganese, cobalt, copper, gallium, strontium, niobium, molybdenum, palladium, indium, tin, tungsten, rhenium, platinum, and gadolinium. The metals are preferably provided in ionic form, derived from an appropriate metal compound, for example the A13+, Ru3+, Zn2+, Fe3+, Ni2+ and Ca2+ ions.

When the RNA or DNA bridge is cut by the activated CRISPR effector, the aforementioned color shift is observed. In certain example embodiments the particles are colloidal metals. In certain other example embodiments, the colloidal metal is a colloidal gold. In certain example embodiments, the colloidal nanoparticles are 15 nm gold nanoparticles (AuNPs). Due to the unique surface properties of colloidal gold nanoparticles, maximal absorbance is observed at 520 nm when fully dispersed in solution and appear red in color to the naked eye. Upon aggregation of AuNPs, they exhibit a red-shift in maximal absorbance and appear darker in color, eventually precipitating from solution as a dark purple aggregate. In certain example embodiments the nanoparticles are modified to include DNA linkers extending from the surface of the nanoparticle. Individual particles are linked together by single-stranded RNA (ssRNA) or single-stranded DNA bridges that hybridize on each end to at least a portion of the DNA linkers. Thus, the nanoparticles will form a web of linked particles and aggregate, appearing as a dark precipitate. Upon activation of the CRISPR effectors disclosed herein, the ssRNA or ssDNA bridge will be cleaved, releasing the AU NPS from the linked mesh and producing a visible red color. Example DNA linkers and bridge sequences are listed below. Thiol linkers on the end of the DNA linkers may be used for surface conjugation to the AuNPS. Other forms of conjugation may be used. In certain example embodiments, two populations of AuNPs may be generated, one for each DNA linker. This will help facilitate proper binding of the ssRNA bridge with proper orientation. In certain example embodiments, a first DNA linker is conjugated by the 3′ end while a second DNA linker is conjugated by the 5′ end.

In certain other example embodiments, the masking construct may comprise an RNA or DNA oligonucleotide to which are attached a detectable label and a masking agent of that detectable label. An example of such a detectable label/masking agent pair is a fluorophore and a quencher of the fluorophore. Quenching of the fluorophore can occur as a result of the formation of a non-fluorescent complex between the fluorophore and another fluorophore or non-fluorescent molecule. This mechanism is known as ground-state complex formation, static quenching, or contact quenching. Accordingly, the RNA or DNA oligonucleotide may be designed so that the fluorophore and quencher are in sufficient proximity for contact quenching to occur. Fluorophores and their cognate quenchers are known in the art and can be selected for this purpose by one having ordinary skill in the art. The particular fluorophore/quencher pair is not critical in the context of this invention, only that selection of the fluorophore/quencher pairs ensures masking of the fluorophore. Upon activation of the effector proteins disclosed herein, the RNA or DNA oligonucleotide is cleaved thereby severing the proximity between the fluorophore and quencher needed to maintain the contact quenching effect. Accordingly, detection of the fluorophore may be used to determine the presence of a target molecule in a sample.

In certain other example embodiments, the masking construct may comprise one or more RNA oligonucleotides to which are attached one or more metal nanoparticles, such as gold nanoparticles. In some embodiments, the masking construct comprises a plurality of metal nanoparticles crosslinked by a plurality of RNA or DNA oligonucleotides forming a closed loop. In one embodiment, the masking construct comprises three gold nanoparticles crosslinked by three RNA or DNA oligonucleotides forming a closed loop. In some embodiments, the cleavage of the RNA or DNA oligonucleotides by the CRISPR effector protein leads to a detectable signal produced by the metal nanoparticles.

In certain other example embodiments, the masking construct may comprise one or more RNA or DNA oligonucleotides to which are attached one or more quantum dots. In some embodiments, the cleavage of the RNA or DNA oligonucleotides by the CRISPR effector protein leads to a detectable signal produced by the quantum dots.

In one example embodiment, the masking construct may comprise a quantum dot. The quantum dot may have multiple linker molecules attached to the surface. At least a portion of the linker molecule comprises RNA or DNA. The linker molecule is attached to the quantum dot at one end and to one or more quenchers along the length or at terminal ends of the linker such that the quenchers are maintained in sufficient proximity for quenching of the quantum dot to occur. The linker may be branched. As above, the quantum dot/quencher pair is not critical, only that selection of the quantum dot/quencher pair ensures masking of the fluorophore. Quantum dots and their cognate quenchers are known in the art and can be selected for this purpose by one having ordinary skill in the art. Upon activation of the effector proteins disclosed herein, the RNA or DNA portion of the linker molecule is cleaved thereby eliminating the proximity between the quantum dot and one or more quenchers needed to maintain the quenching effect. In certain example embodiments the quantum dot is streptavidin conjugated. RNA or DNA are attached via biotin linkers and recruit quenching molecules with the sequences/5Biosg/UCUCGUACGUUC/3IAbRQSp/(SEQ ID NO: 62014) or /5Biosg/UCUCGUACGUUCUCUCGUACGUUC/3IAbRQSp/(SEQ ID NO: 62015) where /5Biosg/ is a biotin tag and/31AbRQSp/ is an Iowa black quencher (Iowa Black FQ). Upon cleavage, by the activated effectors disclosed herein the quantum dot will fluoresce visibly.

In specific embodiments, the detectable ligand may be a fluorophore and the masking component may be a quencher molecule.

In a similar fashion, fluorescence energy transfer (FRET) may be used to generate a detectable positive signal. FRET is a non-radiative process by which a photon from an energetically excited fluorophore (i.e. “donor fluorophore”) raises the energy state of an electron in another molecule (i.e. “the acceptor”) to higher vibrational levels of the excited singlet state. The donor fluorophore returns to the ground state without emitting a fluoresce characteristic of that fluorophore. The acceptor can be another fluorophore or non-fluorescent molecule. If the acceptor is a fluorophore, the transferred energy is emitted as fluorescence characteristic of that fluorophore. If the acceptor is a non-fluorescent molecule the absorbed energy is loss as heat. Thus, in the context of the embodiments disclosed herein, the fluorophore/quencher pair is replaced with a donor fluorophore/acceptor pair attached to the oligonucleotide molecule. When intact, the masking construct generates a first signal (negative detectable signal) as detected by the fluorescence or heat emitted from the acceptor. Upon activation of the effector proteins disclosed herein the RNA oligonucleotide is cleaved and FRET is disrupted such that fluorescence of the donor fluorophore is now detected (positive detectable signal).

In certain example embodiments, the masking construct comprises the use of intercalating dyes which change their absorbance in response to cleavage of long RNAs or DNAs to short nucleotides. Several such dyes exist. For example, pyronine-Y will complex with RNA and form a complex that has an absorbance at 572 nm. Cleavage of the RNA results in loss of absorbance and a color change. Methylene blue may be used in a similar fashion, with changes in absorbance at 688 nm upon RNA cleavage. Accordingly, in certain example embodiments the masking construct comprises a RNA and intercalating dye complex that changes absorbance upon the cleavage of RNA by the effector proteins disclosed herein.

In certain example embodiments, the masking construct may comprise an initiator for an HCR reaction. See e.g. Dirks and Pierce. PNAS 101, 15275-15728 (2004). HCR reactions utilize the potential energy in two hairpin species. When a single-stranded initiator having a portion of complementary to a corresponding region on one of the hairpins is released into the previously stable mixture, it opens a hairpin of one speces. This process, in turn, exposes a single-stranded region that opens a hairpin of the other species. This process, in turn, exposes a single stranded region identical to the original initiator. The resulting chain reaction may lead to the formation of a nicked double helix that grows until the hairpin supply is exhausted. Detection of the resulting products may be done on a gel or colorimetrically. Example colorimetric detection methods include, for example, those disclosed in Lu et al. “Ultra-sensitive colorimetric assay system based on the hybridization chain reaction-triggered enzyme cascade amplification ACS Appl Mater Interfaces, 2017, 9(1):167-175, Wang et al. “An enzyme-free colorimetric assay using hybridization chain reaction amplification and split aptamers” Analyst 2015, 150, 7657-7662, and Song et al. “Non-covalent fluorescent labeling of hairpin DNA probe coupled with hybridization chain reaction for sensitive DNA detection.” Applied Spectroscopy, 70(4): 686-694 (2016).

In certain example embodiments, the masking construct suppresses generation of a detectable positive signal until cleaved, or modified by an activated CRISPR effector protein. In some embodiments, the masking construct may suppress generation of a detectable positive signal by masking the detectable positive signal, or generating a detectable negative signal instead.

Devices for Detection Assays

In certain embodiments, the detection assay can be provided on a cartridge or chip. In an aspect, the cartridge can comprise one or more ampoules and one or more wells that are communicatively coupled, allowing for the transfer, exchange or movement of reagents and sample with or without the use of beads through the chambers of the cartridge and facilitating detection assays utilizing systems/devices for facilitating the detection assay on the cartridge.

Cartridge

The cartridge, also referred to herein as a chip, according to the present invention comprises a series of components of ampoules and chambers that are communicatively coupled with one or more other components on the cartridge. The coupling is typically a fluidic communication, for example, via channels. The cartridge may comprise a membrane that seals one or more of the chambers and/or ampoules. In an aspect, the membrane allows for storage of reagents, buffers and other solid or fluid components which cover and seal the cartridge. The membrane can be configured to be punctured, pierced or otherwise released from sealing or covering one or more components of the cartridge by a means for releasing reagents.

As noted above, certain embodiments enable the use of nucleic acid binding beads to concentrate target nucleic acid but that do not require elution of the isolated nucleic acid. Thus, in certain example embodiments, the cartridge may further comprise an activatable magnet, such as an electro-magnet. A means for activating the magnet may be located on the device, or the means for supplying the magnet or activating the magnet on the cartridge may be provided by a second device, such as those disclosed in further detail below.

An exemplary cartridge is depicted in FIG. 30A-30B. This embodiment is by way of example only, and it should be understood that other configurations of individual components on the cartridge are also envisioned without departing from the overall scope and function of the invention. The cartridge (10) can comprise two or more ampoules (80,90). A first chamber for receiving a sample (30) is also provided and can be communicatively connected to an ampoule (90) and a second chamber (40). The second chamber (40) may be a lysis chamber. The lysis chamber can in turn be communicatively connected to a channel (100). The channel (100) may be a metering channel that is communicatively coupled to an ampoule (90) and a third chamber (60). The third chamber (60) may be an amplification chamber. Hyrdophobic vents can be disposed on the cartridge (50, 70). FIG. 30B shows the cartridge body (15) with a membrane cover or laminate film (12).

The overall size of the device may be between 10, 15, 20, 25, 30, 35, 40, 45, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100 mm in width, and 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, or 200 mm. The sizing of ampoules, chambers, and channels can be selected to be in line with the reaction volumes discussed herein and to fit within the general size parameters of the overall cartridge.

Ampoules

The ampoules, also referred to as blisters, allow for storage and release of reagents throughout the cartridge. Ampoules can include liquid or solid reagents, for example, lysis reagents in one ampoule and reaction reagents in another ampoule. The reagents can be as described elsewhere herein, and can be adapted for the use in the cartridge. The ampoule may be sealed by a film that allows for the bursting, puncture or other release of the contents of the ampoules. See, e.g. Becker, H. & Gartner, C. Microfluidics-enabled diagnostic systems: markets, challenges, and examples. In Microchip Diagnostics: Methods and Protocols (eds Taly, V. et al.) (Springer, New York, 2017); Czurratis et al., doi: 10.1088/0960-1317/25/4/045002. Considerations for ampoules can include as discussed in, for example, Smith, S., et al., Blister pouches for effective reagent storage on microfluidic chips for blood cell counting. Microfluid Nanofluid 20, 163 (2016). DOI:10.1007/s10404-016-1830-2. In an aspect, the seal is a frangible seal formed of a composite-layer film that is assembled to the cartride main body. While referred to herein as an ampoule, the ampoule may comprise a cavity on a chip which comprises a sealed film that is opened by the release means.

Chambers

The chambers on the chip may located and sized for fluidic communication via channels or other communication means with ampoules and/or other chambers on the chip, see, e.g. FIG. 30A. A chamber for receiving a sample can be provided. The sample can be injected, placed in a receptacle into the chamber for receiving a sample, or otherwise transferred to the chamber. A lysis chamber may comprise, for example, capture beads, that may be used for concentration and/or extraction of the desired target material from the sample. Alternatively, the beads may be comprised in an ampoule comprising lysis reagents that are in fluidic communication with the lysis chamber. An amplification chamber may also be provided with, for example, one or more lyophilized components of the system in the amplification chamber and/or communicatively connected to an ampoule comprising one or more components of the amplification reaction.

When the cartridge comprises a magnet, it may be configured near one or more of the chambers. In an aspect, the magnet is near the lysis well, and may be configured such that the device has a means for activating the magnet. Embodiments comprising a magnet in the cartridge may be utilized with methodologies using magnetic beads for extraction of particular target molecules.

System for Detection Assays

A system configured for use with the cartridge and to perform an assay, also referred to as a sample analysis apparatus, detection system or detection device, is configured system to receive the cartridge and conduct an assay comprising isothermal amplification of nucleic acids and detection of target nucleic acids on the cartridge. The system may comprise: a body; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge or other closure means; a cartridge accommodating unit included in the detection system and configured to accommodate the cartridge. The system may further comprise one or more means for releasing reagents for extractions, amplification and/or detection; one or more heating means for extractions, amplification and/or detection, a means for mixing reagents for extraction, amplification, and/or detections, and/or a menas for reading the results of the assay. The device may further comprise a user interface for programming the device and/or readout of the results of the assay.

Means for Release of Reagents

The system may comprise means for releasing reagents for extraction, amplification and/or detection. Release of reagents can be performed by a crushing, puncturing, applying heat or pressure until burst, cutting, or other means for the opening of the ampoule and release of contents. e.g. Becker, H. & Gartner, C. Microfluidics-enabled diagnostic systems: markets, challenges, and examples. In Microchip Diagnostics: Methods and Protocols (eds Taly, V. et al.) (Springer, New York, 2017); Czurratis et al., doi: 10.1088/0960-1317/25/4/045002. Mechanical actuators

Heating Means

The heating means or heating element can be provided, for example, by electrical or chemical elements. One or more heating means can be utilized, or circuits providing regulation of temperature to one or more locations within the detection device can be utilized. In one preferred embodiment the device is configured to comprise a heating means for heating the lysis (extraction) chamber and at the amplification chamber of the cartridge. In an aspect, the heating element is disposed under the extraction well. The system can be designed with one or more heating means for extraction, amplification and/or detection.

Mixing Means

A means for mixing reagents for extraction, amplification and/or detection can be provided. A means for mixing reagents may comprise a means for mixing one or more fluids, or a fluid with a solid or lyophilized reaction mixture can also be provided. Means for mixing that disturb the laminar flow can be provided. In an aspect, the mixing means is a passive mixer, in another aspect, the mixing means is an active mixer. See, e.g. Nam-Trung Nguyen and Zhigang Wu 2005 J. Micromech. Microeng. 15 R1, doi: 10.1088/0960-1317/15/2/R01 for discussion of mixing approaches. In an aspect, the active mixer can be based on external sources such as pressure, temperature, hydrodynamics (with electrical or magnetic forces), dielectrophoresis, electrokinetics, or acoustics. Examples of passive mixing means can be provided by use of geometric approaches, such as a curved path or channel, see, e.g. U.S. Pat. No. 7,160,025, or an expansion/contraction of a channel cross section or diameter. When the cartridge is utilized with beads, channels and wells are configured and sized for the flow of beads.

Means for Reading the Results of the Assay

A means for reading the results of the assay can be provided in the system. The means for reading the results of the assay will depend in part on the type of detectable signal generated by the assay. In particular embodiments, the assay generates a detectable fluorescent or color readout. In these instances, the means for reading the results of the assay will be an optic means, for example a single channel or multi-channel optical means such as a fluorimeter, colorimeter or other spectroscopic sensor.

A combination of means for reading the results of the assay can be utilized, and may include readings such as turbidity, temperature, magnetic, radio, or electrical properties and or optical properties, including scattering, polarization effects, etc.

The system may further comprise a user interface for programming the device and/or readout of the results of the assay. The user interface may comprise an LED screen. The system can be further configured for a USB port that can allow for docking of four or more devices.

In an aspect, the system comprises a means for activating a magnet that is disposed within or on the cartridge.

Lateral Flow Devices

In certain embodiments, the detection assay can be provided on a lateral flow device, as described in International Publication WO 2019/071051, incorporated herein by reference. The lateral flow device can be adapted to detect one or more coronaviruses and/or other viruses in combination of the coronavirus. The lateral flow device may comprise a flexible substrate, such as a paper substrate or a flexible polymer-based substrate, which can include freeze-dried reagents for detection assays with a visual readout of the assay results. See, WO 2019/071051 at [0145]-[0151] and Example 2, specifically incorporated herein by reference. In an aspect, lyophilized reagents can include preferred excipients that aid in rate of reaction, specificity, or other variables. The excipients may comprise trehalose, histidine, and/or glycine. In certain embodiments, the coronavirus assay can be utilized with isothermal amplification reagents, allowing amplification without complex instrumentation that may be unavailable in the field, as described in WO 2019/071051. Accordingly, the assay can be adapted for field diagnostics, including use of visual readout on a lateral flow device, rapid, sensitive detection and can be deployed for early and direct detection. Colorimetric detection can be utilized and may be particularly suited for field deployable applications, as described in International Application PCT/US2019/015726, published as WO2019/148206. In particular, colorimetric detection can be as described in WO2019/148206 at FIGS. 102, 105, 107-111 and [00306]-[00324], incorporated herein by reference.

In one embodiment, the invention provides a lateral flow device comprising a substrate comprising a first end and a second end. The first end may comprise a sample loading portion, a first region comprising a detectable ligand, two or more CRISPR effector systems, two or more detection constructs, and one or more first capture regions, each comprising a first binding agent. The substrate may also comprise two or more second capture regions between the first region of the first end and the second end, each second capture region comprising a different binding agent. Each of the two or more CRISPR effector systems may comprise a CRISPR effector protein and one or more guide sequences, each guide sequence configured to bind one or more target molecules.

The embodiments disclosed herein are directed to lateral flow detection devices that comprise SHERLOCK systems.

The device may comprise a lateral flow substrate for detecting a SHERLOCK reaction. Substrates suitable for use in lateral flow assays are known in the art. These may include, but are not necessarily limited to membranes or pads made of cellulose and/or glass fiber, polyesters, nitrocellulose, or absorbent pads (J Saudi Chem Soc 19(6):689-705; 2015), and other embodiments further described herein. The SHERLOCK system, i.e. one or more CRISPR systems and corresponding reporter constructs are added to the lateral flow substrate at a defined reagent portion of the lateral flow substrate, typically on one end of the lateral flow substrate. Reporting constructs used within the context of the present invention can comprise a first molecule and a second molecule linked by an RNA or DNA linker. The lateral flow substrate further comprises a sample portion. The sample portion may be equivalent to, continuous with, or adjacent to the reagent portion. In an aspect, the lateral flow substrate can be contained within a further device (see, e.g. FIG. 21 ). In an aspect, the lateral flow substrate can be utilized for visual readout of a detectable signal in one-pot reactions, e.g. wherein steps of extracting, amplifying and detecting are performed in an individual discrete volume.

Lateral Flow Substrate

In certain example embodiments, a lateral flow device comprises a lateral flow substrate on which detection can be performed. Substrates suitable for use in lateral flow assays are known in the art. These may include, but are not necessarily limited to, membranes or pads made of cellulose and/or glass fiber, polyesters, nitrocellulose, or absorbent pads (J Saudi Chem Soc 19(6):689-705; 2015).

Lateral support substrates comprise a first and second end, and one or more capture regions that each comprise binding agents. The first end may comprise a sample loading portion, a first region comprising a detectable ligand, two or more CRISPR effector systems, two or more detection constructs, and one or more first capture regions, each comprising a first binding agent. The substrate may also comprise two or more second capture regions between the first region of the first end and the second end, each second capture region comprising a different binding agent. Each of the two or more CRISPR effector systems may comprise a CRISPR effector protein and one or more guide sequences, each guide sequence configured to bind one or more target molecules. The lateral flow substrates may be configured to detect a SHERLOCK reaction.

Lateral support substrates may be located within a housing (see for example, “Rapid Lateral Flow Test Strips” Merck Millipore 2013). The housing may comprise at least one opening for loading samples and a second single opening or separate openings that allow for reading of detectable signal generated at the first and second capture regions.

The embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA. Accordingly, the lateral substrate comprising one or more of the elements of the system, including detectable ligands, CRISPR effector systems, detection constructs and binding agents may be freeze-dried to the lateral flow substrate and packaged as a ready to use device. Alternatively, all or a portion of the elements of the system may be added to the reagent portion of the lateral flow substrate at the time of using the device.

First End and Second End of the Substrate

The substrate of the lateral flow device comprises a first and second end. The SHERLOCK system, i.e. one or more CRISPR systems and corresponding reporter constructs are added to the lateral flow substrate at a defined reagent portion of the lateral flow substrate, typically on a first end of the lateral flow substrate. Reporting constructs used within the context of the present invention comprise a first molecule and a second molecule linked by an RNA or DNA linker. The lateral flow substrate further comprises a sample portion. The sample portion may be equivalent to, continuous with, or adjacent to the reagent portion.

In certain example embodiments, the first end comprises a first region. The first region comprises a detectable ligand, two or more CRISPR effector systems, two or more detection constructs, and one or more first capture regions, each comprising a first binding agent.

Capture Regions

The lateral flow substrate can comprise one or more capture regions. In embodiments the first end of the lateral flow substrate comprises one or more first capture regions, with two or more second capture regions between the first region of the first end of the substrate and the second end of the substrate. The capture regions may be provided as a capture line, typically a horizontal line running across the device, but other configurations are possible. The first capture region is proximate to and on the same end of the lateral flow substrate as the sample loading portion.

Binding Agents

Specific binding-integrating molecules comprise any members of binding pairs that can be used in the present invention. Such binding pairs are known to those skilled in the art and include, but are not limited to, antibody-antigen pairs, enzyme-substrate pairs, receptor-ligand pairs, and streptavidin-biotin. In addition to such known binding pairs, novel binding pairs may be specifically designed. A characteristic of binding pairs is the binding between the two members of the binding pair.

A first binding agent that specifically binds the first molecule of the reporter construct is fixed or otherwise immobilized to the first capture region. The second capture region is located towards the opposite end of the lateral flow substrate from the first capture region. A second binding agent is fixed or otherwise immobilized at the second capture region. The second binding agent specifically binds the second molecule of the reporter construct, or the second binding agent may bind a detectable ligand. For example, the detectable ligand may be a particle, such as a colloidal particle, that when it aggregates can be detected visually, and generates a detectable positive signal. The particle may be modified with an antibody that specifically binds the second molecule on the reporter construct. If the reporter construct is not cleaved it will facilitate accumulation of the detectable ligand at the first binding region. If the reporter construct is cleaved the detectable ligand is released to flow to the second binding region. In such an embodiment, the second binding region comprises a second binding agent capable of specifically or non-specifically binding the detectable ligand on the antibody of the detectable ligand. Binding agents can be, for example, antibodies, that recognize a particular affinity tag. Such binding agents can further contain, for example, detectable labels, such as isotope labels and/or nucleic acid barcodes. A barcode is a short sequence of nucleotides (for example, DNA, RNA, or combinations thereof) that is used as an identifier. A nucleic acid barcode may have a length of 4-100 nucleotides and be either single or double-stranded. Methods for identifying cells with barcodes are known in the art. Accordingly, guide RNAs of the CRISPR effector systems described herein may be used to detect the barcode.

Detectable Ligands

The first region is loaded with a detectable ligand, such as those disclosed herein, for example a gold nanoparticle. The detectable ligand may be a particle, such as a colloidal particle, that when it aggregates can be detected visually. The particle may be modified with an antibody that specifically binds the second molecule on the reporter construct. If the reporter construct is not cleaved it will facilitate accumulation of the detectable ligand at the first binding region. If the reporter construct is cleaved the detectable ligand is released to flow to the second binding region. In such an embodiment, the second binding agent is an agent capable of specifically or non-specifically binding the detectable ligand on the antibody on the detectable ligand. Examples of suitable binding agents for such an embodiment include, but are not limited to, protein A and protein G. In some examples, the detectable ligand is a gold nanoparticle, which may be modified with a first antibody, such as an anti-FITC antibody.

Lateral Flow Detection Constructs

The first region also comprises a detection construct. In one example embodiment, a RNA detection construct and a CRISPR effector system (a CRISPR effector protein and one or more guide sequences configured to bind to one or more target sequences) as disclosed herein. In one example embodiment, and for purposes of further illustration, the RNA construct may comprise a FAM molecule on a first end of the detection construction and a biotin on a second end of the detection construct. Upstream of the flow of solution from the first end of the lateral flow substrate is a first test band. The test band may comprise a biotin ligand. Accordingly, when the RNA detection construct is present it its initial state, i.e. in the absence of target, the FAM molecule on the first end will bind the anti-FITC antibody on the gold nanoparticle, and the biotin on the second end of the RNA construct will bind the biotin ligand allowing for the detectable ligand to accumulate at the first test, generating a detectable signal. Generation of a detectable signal at the first band indicates the absence of the target ligand. In the presence of target, the CRISPR effector complex forms and the CRISPR effector protein is activated resulting in cleavage of the RND detection construct. In the absence of intact RNA detection construct the colloidal gold will flow past the second strip. The lateral flow device may comprise a second band, upstream of the first band. The second band may comprise a molecule capable of binding the antibody-labeled colloidal gold molecule, for example an anti-rabbit antibody capable of binding a rabbit anti-FITC antibody on the colloidal gold. Therefore, in the presence of one or more targets, the detectable ligand will accumulate at the second band, indicating the presence of the one or more targets in the sample.

In some embodiments, the first end of the lateral flow device comprises two detection constructs and each of the two detection constructs comprises an RNA or DNA oligonucleotide, comprising a first molecule on a first end and a second molecule on a second end. The first molecule and the second molecule may be linked by an RNA or DNA linker.

In some embodiments, the first molecule on the first end of the first detection construct may be FAM and the second molecule on the second end of the first detection construct may be biotin, or vice versa. In some embodiments, the first molecule on the first end of the second detection construct may be FAM and the second molecule on the second end of the second detection construct may be Digoxigenin (DIG), or vice versa.

In some embodiments, the first end may comprise three detection constructs, wherein each of the three detection constructs comprises an RNA or DNA oligonucleotide, comprising a first molecule on a first end and a second molecule on a second end. In specific embodiments, the first and second molecules on the detection constructs comprise Tye 665 and Alexa 488; Tye 665 and FAM, and Tye 665 and Digoxigenin (DIG), respectively.

In some embodiments, the first end of the lateral flow device comprises two or more CRISPR effector systems, also referred to as a CRISPR-Cas or CRISPR system. In some embodiments, such a CRISPR effector system may include a CRISPR effector protein and one or more guide sequences configured to bind to one or more target sequences.

Samples

When utilizing the detection systems with a lateral flow substrate, samples to be screened are loaded at the sample loading portion of the lateral flow substrate. The samples must be liquid samples or samples dissolved in an appropriate solvent, usually aqueous. The liquid sample reconstitutes the SHERLOCK reagents such that a SHERLOCK reaction can occur. The liquid sample begins to flow from the sample portion of the substrate towards the first and second capture regions.

A sample for use with the invention may be a biological or environmental sample, such as a surface sample, a fluid sample, or a food sample (fresh fruits or vegetables, meats). Food samples may include a beverage sample, a paper surface, a fabric surface, a metal surface, a wood surface, a plastic surface, a soil sample, a freshwater sample, a wastewater sample, a saline water sample, exposure to atmospheric air or other gas sample, or a combination thereof. For example, household/commercial/industrial surfaces made of any materials including, but not limited to, metal, wood, plastic, rubber, or the like, may be swabbed and tested for contaminants. Soil samples may be tested for the presence of pathogenic bacteria or parasites, or other microbes, both for environmental purposes and/or for human, animal, or plant disease testing. Water samples such as freshwater samples, wastewater samples, or saline water samples can be evaluated for cleanliness and safety, and/or potability, to detect the presence of, for example, Cryptosporidium parvum, Giardia lamblia, or other microbial contamination. In further embodiments, a biological sample may be obtained from a source including, but not limited to, a tissue sample, saliva, blood, plasma, sera, stool, urine, sputum, mucous, lymph, synovial fluid, spinal fluid, cerebrospinal fluid, ascites, pleural effusion, seroma, pus, bile, aqueous or vitreous humor, transudate, exudate, or swab of skin or a mucosal membrane surface. In some particular embodiments, an environmental sample or biological samples may be crude samples and/or the one or more target molecules may not be purified or amplified from the sample prior to application of the method. Identification of microbes may be useful and/or needed for any number of applications, and thus any type of sample from any source deemed appropriate by one of skill in the art may be used in accordance with the invention.

In particular embodiments, the methods and systems can be utilized for direct detection from patient samples. In an aspect, the methods and systems can further allow for direct detection from patient samples with a visual readout to further facilitate field-deployability. In an aspect, a field depoloyable version can include, for example the lateral flow devices and systems as described herein, and/or colorimetric detection. The methods and systems can be utilized to distinguish multiple viral species and strains and identify clinically relevant mutations, important with viral outbreaks such as the coronavirus outbreak in Wuhan (2019-nCoV). In an aspect, the sample is from a nasophyringeal swab or a saliva sample. See., e.g. FIG. 40 , see also, Wyllie et al., “Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs,” DOI: 10.1101/2020.04.16.20067835.

Methods for Detecting and/or Quantifying Target Nucleic Acids

In some embodiments, the invention provides methods for detecting target nucleic acids in a sample. Such methods may comprise contacting a sample with the first end of a lateral flow device as described herein. The first end of the lateral flow device may comprise a sample loading portion, wherein the sample flows from the sample loading portion of the substrate towards the first and second capture regions and generates a detectable signal.

A positive detectable signal may be any signal that can be detected using optical, fluorescent, chemiluminescent, electrochemical or other detection methods known in the art, as described elsewhere herein.

In some embodiments, the lateral flow device may be capable of detecting two different target nucleic acid sequences. In some embodiments, this detection of two different target nucleic acid sequences may occur simultaneously.

In some embodiments, the absence of target nucleic acid sequences in a sample elicits a detectable fluorescent signal at each capture region. In such instances, the absence of any target nucleic acid sequences in a sample may cause a detectable signal to appear at the first and second capture regions.

In some embodiments, the lateral flow device as described herein is capable of detecting three different target nucleic acid sequences. In specific embodiments, when the target nucleic acid sequences are absent from the sample, a fluorescent signal may be generated at each of the three capture regions. In such exemplary embodiments, a fluorescent signal may be absent at the capture region for the corresponding target nucleic acid sequence when the sample contains one or more target nucleic acid sequences.

Samples to be screened are loaded at the sample loading portion of the lateral flow substrate. The samples must be liquid samples or samples dissolved in an appropriate solvent, usually aqueous. The liquid sample reconstitutes the system reagents such that a SHERLOCK reaction can occur. Intact reporter construct is bound at the first capture region by binding between the first binding agent and the first molecule. Likewise, the detection agent will begin to collect at the first binding region by binding to the second molecule on the intact reporter construct. If target molecule(s) are present in the sample, the CRISPR effector protein collateral effect is activated. As activated CRISPR effector protein comes into contact with the bound reporter construct, the reporter constructs are cleaved, releasing the second molecule to flow further down the lateral flow substrate towards the second binding region. The released second molecule is then captured at the second capture region by binding to the second binding agent, where additional detection agent may also accumulate by binding to the second molecule. Accordingly, if the target molecule(s) is not present in the sample, a detectable signal will appear at the first capture region, and if the target molecule(s) is present in the sample, a detectable signal will appear at the location of the second capture region.

In some embodiments, the invention provides a method for quantifying target nucleic acids in samples comprising distributing a sample or set of samples into one or more individual discrete volumes comprising two or more CRISPR systems as described herein. The method may comprise using HDA to amplify one or more target molecules in the sample or set of samples, as described herein. The method may further comprise incubating the sample or set of samples under conditions sufficient to allow binding of the guide RNAs to one or more target molecules. The method may further comprise activating the CRISPR effector protein via binding of the guide RNAs to the one or more target molecules. Activating the CRISPR effector protein may result in modification of the detection construct such that a detectable positive signal is generated. The method may further comprise detecting the one or more detectable positive signals, wherein detection indicates the presence of one or more target molecules in the sample. The method may further comprise comparing the intensity of the one or more signals to a control to quantify the nucleic acid in the sample. The steps of amplifying, incubating, activating, and detecting may all be performed in the same individual discrete volume.

An “individual discrete volume” is a discrete volume or discrete space, such as a container, receptacle, or other defined volume or space that can be defined by properties that prevent and/or inhibit migration of nucleic acids and reagents necessary to carry out the methods disclosed herein, for example a volume or space defined by physical properties such as walls, for example the walls of a well, tube, or a surface of a droplet, which may be impermeable or semipermeable, or as defined by other means such as chemical, diffusion rate limited, electro-magnetic, or light illumination, or any combination thereof. By “diffusion rate limited” (for example diffusion defined volumes) is meant spaces that are only accessible to certain molecules or reactions because diffusion constraints effectively defining a space or volume as would be the case for two parallel laminar streams where diffusion will limit the migration of a target molecule from one stream to the other. By “chemical” defined volume or space is meant spaces where only certain target molecules can exist because of their chemical or molecular properties, such as size, where for example gel beads may exclude certain species from entering the beads but not others, such as by surface charge, matrix size or other physical property of the bead that can allow selection of species that may enter the interior of the bead. By “electro-magnetically” defined volume or space is meant spaces where the electro-magnetic properties of the target molecules or their supports such as charge or magnetic properties can be used to define certain regions in a space such as capturing magnetic particles within a magnetic field or directly on magnets. By “optically” defined volume is meant any region of space that may be defined by illuminating it with visible, ultraviolet, infrared, or other wavelengths of light such that only target molecules within the defined space or volume may be labeled. One advantage to the used of non-walled, or semipermeable is that some reagents, such as buffers, chemical activators, or other agents maybe passed in Applicants' through the discrete volume, while other material, such as target molecules, maybe maintained in the discrete volume or space. Typically, a discrete volume will include a fluid medium, (for example, an aqueous solution, an oil, a buffer, and/or a media capable of supporting cell growth) suitable for labeling of the target molecule with the indexable nucleic acid identifier under conditions that permit labeling. Exemplary discrete volumes or spaces useful in the disclosed methods include droplets (for example, microfluidic droplets and/or emulsion droplets), hydrogel beads or other polymer structures (for example poly-ethylene glycol di-acrylate beads or agarose beads), tissue slides (for example, fixed formalin paraffin embedded tissue slides with particular regions, volumes, or spaces defined by chemical, optical, or physical means), microscope slides with regions defined by depositing reagents in ordered arrays or random patterns, tubes (such as, centrifuge tubes, microcentrifuge tubes, test tubes, cuvettes, conical tubes, and the like), bottles (such as glass bottles, plastic bottles, ceramic bottles, Erlenmeyer flasks, scintillation vials and the like), wells (such as wells in a plate), plates, pipettes, or pipette tips among others. In certain example embodiments, the individual discrete volumes are the wells of a microplate. In certain example embodiments, the microplate is a 96 well, a 384 well, or a 1536 well microplate.

Incubating the sample at either the amplification step or the extraction steps as described herein can be performed using heat sources known in the art. Advantageously, the heat source can be readily commercially available heating sources that do not require complicated instrumentation. The heating sources can be included in a device that allows for the one-pot reaction detailed herein. Exemplary heating systems can include heating blocks, incubators, and/or water baths with temperatures maintained by commercially available sous-vide cookers. In this way, sample diagnostics can be performed without the requirement of expensive and proprietary equipment found primarily in diagnostic laboratory and hospital settings.

In certain example embodiments, paper-based microfluidics may be used for transfer of samples or reagents. For example, paper strips having wax barrier printed at a defined distance from the end of a paper dipstick may be used to define a volume of reagent or sample to be transferred. For example, a wax barrier may be printed across a paper dipstick to define a microliter volume such that when the dipstick is transferred into a volume of a reagent or sample only a microliter of said reagent or sample is absorbed onto the dipstick. The dipstick may be place in a second reagent mix, where the reagent or sample will diffuse into the reaction mixture. Such components allow for preparation and use of the assay without specialized equipment such as pipettors.

Optical means may be used to assess the presence and level of a given target molecule. In certain embodiments, an optical sensor detects unmasking of a fluorescent masking agent. In certain embodiments, the device of the present invention may include handheld portable devices for diagnostic reading of an assay (see e.g., Vashist et al., Commercial Smartphone-Based Devices and Smart Applications for Personalized Healthcare Monitoring and Management, Diagnostics 2014, 4(3), 104-128; mReader from Mobile Assay; and Holomic Rapid Diagnostic Test Reader). As provided in Example 10, Applicants have developed an application for mobile devices that aid a user in interpreting lateral flow results (FIGS. 63C and 65A-65B).

As noted herein, certain embodiments allow detection via colorimetric change which has certain attendant benefits when embodiments are utilized in POC situations and or in resource poor environments where access to more complex detection equipment to readout the signal may be limited. However, portable embodiments disclosed herein may also be coupled with hand-held spectrophotometers that enable detection of signals outside the visible range. An example of a hand-held spectrophotometer device that may be used in combination with the present invention is described in Das et al. “Ultra-portable, wireless smartphone spectrophotometer for rapid, non-destructive testing of fruit ripeness.” Nature Scientific Reports. 2016, 6:32504, DOI: 10.1038/srep32504. Finally, in certain embodiments utilizing quantum dot-based masking constructs, use of a hand-held UV light, or other suitable device, may be successfully used to detect a signal owing to the near complete quantum yield provided by quantum dots.

Amplifying Target Molecules

The step of amplifying one or more target molecules can comprise amplification systems known in the art. In some embodiments, amplification is isothermal. In certain example embodiments, target RNAs and/or DNAs may be amplified prior to activating the CRISPR effector protein. Any suitable RNA or DNA amplification technique may be used. In certain embodiments, the amplifying step may take less than about 1 hour, 50 minutes, 40 minutes, 30 minutes, 25 minutes, 20 minutes or 15 minutes, which may depend on the sample, starting concentrations and nature of amplification used.

In certain embodiments, the amplifying of the target molecules and the detection of the target molecules can be performed in a single reaction, for example, a ‘one-pot’ method. Guidance for use of a single-pot approach can be as described in Gootenberg, et al., Science 2018 Apr. 27:360 (6387) 439-444 (using Cas13, Cas12a and Csm6 generally, detecting multiple targets in a single reaction, and specifically performing DNA extraction in a sample and using as input for direct detection at Figure S33); and Ding et al., “All-in-One Dual CRISPR-Cas12a (AIOD-CRISPR) Assay: A Case for Rapid, Ultrasensitive and Visual Detection of Novel Coronavirus SARS-CoV-2 and HIV Virus,” doi:10.1101/2020.03.19.998724, biorxiv preprint (utilizing a pair of crRNAs with dual CRISPR-Cas12a detection for a one-pot approach to target-specific nucleic acid detection); and International Patent Application PCT/US2020/022795, filed Mar. 13, 2020, incorporated herein by reference in its entirety.

In certain example embodiments, the RNA or DNA amplification is an isothermal amplification. In certain example embodiments, the isothermal amplification may be nucleic-acid sequenced-based amplification (NASBA), recombinase polymerase amplification (RPA), loop-mediated isothermal amplification (LAMP), strand displacement amplification (SDA), helicase-dependent amplification (HDA), or nicking enzyme amplification reaction (NEAR). In certain example embodiments, non-isothermal amplification methods may be used which include, but are not limited to, PCR, multiple displacement amplification (MDA), rolling circle amplification (RCA), ligase chain reaction (LCR), or ramification amplification method (RAM).

The amplifying of target molecules can be optimized by methods as detailed herein. In an aspect, the design optimizes the primers used in the amplification, In particular aspects, the isothermal amplification is used alone. In another aspect, the iotheraml amplification is used with CRISPR-Cas systems. In either approach, design considerations can follow a rational design for optimization of the reactions. Optimization of the methods as disclosed herein can include first screening primers to identify one or more sets of primers that work well for a particular target, Cas protein and/or reaction. Once the primers have been screened, titration of magnesium concentration can be performed to identify an optimal magnesium concentration for higher signal to noise readout. Once an optimum magnesium concentration is identified, additional additives are screened at around 20-25% of the reaction, and once additives are identified, these additives, such as those additives identified in FIG. 17 , can be evaluated and varied in concentration to identify optimal reaction kinetics for specific reaction parameters. In an example, varying additives with specific primers, target, Cas protein (when CRISPR system is used), temperature, and other additive concentrations within the reaction can be identified. Optimization can be made with the goal of reducing the number of steps and buffer exchanges that have to occur in the reaction, simplifying the reaction and reducing the risks of contamination at transfer steps. In an aspect, addition of inhibitors, such as proteinase K can be considered so that buffer exchanges can be reduced. Similarly, optimizing the salt levels as well as the type of salt utilized can further facilitate and optimize the one-pot detections disclosed herein. In an aspect, potassium chloride can be utilized rather than sodium choloride when such amplification approaches are used with bead concentration in a lysis step. In certain example embodiments, taurine is provided at a final concentration of about 20 mM to about 100 mM.

Loop-Mediated Isothermal Amplification

In certain example embodiments, a loop-mediated isothermal amplification (LAMP) reaction may be used to target nucleic acids, which encompasses both LAMP and RT-LAMP reactions. LAMP can be performed with a four-primer system for isothermal nucleic acid amplification in conjunction with a polymerase. Notomi et al., Nucleic Acids Res. 2000, 28, 12, Nagamine et al., Molecular and Cellular Probes (2002) 16, 223-229, doi: 10.1006/mcpr.2002.0415. When performing LAMP with a 4-primer system, two loop-forming inner primers, denoted as FIP and BIP, are provided with two outer primers, F3 and B3. The inner primers each contain two distinct sequences, one for priming in the first stage of the amplification and the other sequence for self-priming in subsequent amplification states. The two outer primers initiate strand displacement of nucleic acid strands initiated from the FIP and BIP primers, thereby generating formation of loops and strand displacement nucleic acid synthesis utilizing the provided polymerase. LAMP can be conducted with two to six primers, ranging from only the two loop-forming primers, up to at least the addition of 2 additional primers, LF and LB along with the two outer primers and two inner primers. LAMP technologies advantageously have high specificity and can work at a variety of pH and temperature. In a preferred aspect, the LAMP is an isothermal reaction at between about 45° C. to 75° C., 55 to 70° C. or 60° C. to 65° C. Colorimetric LAMP (Y. Zhang et al., doi:10.1101/2020.92.26.20028373), RT-LAMP (Lamb et al., doi: 10.1101/2020.02.19.20025155; and Yang et al., doi:10.1101/2020.03.02.20030130) have been developed for detection of COVID-19, and are incorporated herein by reference in their entirety.

In certain embodiments, the LAMP reagents may include Bst 2.0+RTx or Bst 3.0 from New England Biolabs. In certain embodiments, the LAMP reagents may comprise colorimetric or fluorescent detection. Detection of LAMP products can be accomplished using colorimetric tools, such as hydroxy napthol blue (see, e.g. Goto, M., et al., Colorimetric detection of loop-mediated isothermal amplification reaction by using hydroxy naphthol blue. Biotechniques, 2009. 46 (3): p. 167-72.) leuco triphenylmethane dyes (see, e.g. Miyamoto, S., et al., Method for colorimetric detection of double-stranded nucleic acid using leuco triphenylmethane dyes. Anal Biochem, 2015. 473: p. 28-33) and pH-sensitive dyes (see, e.g. Tanner, N. A., Y. Zhang, and T. C. Evans, Jr., Visual detection of isothermal nucleic acid amplification using pH-sensitive dyes. Biotechniques, 2015. 58 (2): p. 59-68); as well as fluorescent detection (see, e.g. Yu et al., Clinical Chemistry, hvaa102, doi:10.1093/clinchem/hvaa102 12 May 2020), including use of quenching probes (see, e.g. Shirato et al., J Virol Methods. 2018 August; 258:41-48. doi: 10.1016/j.jviromet.2018.05.006).

In an aspect, the primer sets for LAMP are designed to amplify one or more target sequences, generating amplicons that comprise the one or more target sequences. Optionally, the primers can comprise barcodes that can be designed as described elsewhere herein. Incubating to a temperature sufficient for LAMP amplification, e.g. 50° C.−72° C., more preferably 55° C. to 65° C., using a polymerase and, optionally a reverse transcriptase (in the event RT-LAMP is utilized). Preferably the enzymes utilized in the LAMP reaction are heat-stabilized. LAMP primer sites have been designed, see, e.g. Park et al., “Development of Reverse Transcription Loop-Mediated Isothermal Amplification Assays Targeting SARS-CoV-2” J. of Mol. Diag. (2020). Optionally, a control template is further provided with the sample, which may differ from the target sequence but share primer binding sites. In an exemplary embodiment, visual read out of the detection results can be accomplished using commercially-available lateral flow substrate, e.g. a commercially available paper substrate. In certain embodiments, the LAMP control can comprise ACTB Set 1, and may be optionally be provided in a multiplexed format with the primer set of the target sequence at about 15% to about 50% of the total primer amount, preferably about 20% of the total primer amount.

In certain embodiments, the LAMP primer can be selected from SEQ ID NOS: 1-40499, or Table 1A. In certain embodiments, the primers are designed to target one or more of the targets in Table 1B, for example, Chlamydia trachomatis D/UW-3/CX chromosome, Hepatitis A virus, Hepatitis B virus (strain ayw) genome, Hepatitis C virus (isolate H77) genotype 1, complete cds, Hepatitis C virus genotype 1, Hepatitis C virus genotype 2, Hepatitis C virus genotype 3, genome, Hepatitis C virus genotype 4, genome, Hepatitis C virus genotype 5, genome, Hepatitis C virus genotype 6, Hepatitis C virus genotype 7, Hepatitis delta virus, Hepatitis E virus, Hepatitis E virus rat/R63/DEU/2009, Hepatitis GB virus A, Hepatitis GB virus B, Human adenovirus 54, Human adenovirus A, Human betaherpesvirus 6A, variant A DNA, complete virion genome, isolate U1102, Human coronavirus 229E, Human coronavirus HKU1, Human Coronavirus NL63, Human coronavirus OC43 strain ATCC VR-759, Human gammaherpesvirus 4, Human genital-associated circular DNA virus-1 isolate 349, Human herpesvirus 1 strain 17, Human herpesvirus 2 strain HG52, Human herpesvirus 3, Human herpesvirus 4, Human herpesvirus 5 strain Merlin, Human herpesvirus 6B, Human herpesvirus 7, Human herpesvirus 8 strain GK18, Human immunodeficiency virus 1, Human immunodeficiency virus 2, Human papillomavirus 54, Human papillomavirus 116, Human papillomavirus—1, Human papillomavirus—2, Human papillomavirus—18, Human papillomavirus—61, Human papillomavirus isolate SE379, Human papillomavirus KCS, Human papillomavirus type 4, Human papillomavirus type 6b, Human papillomavirus type 7 genomic DNA, Human papillomavirus type 9, Human papillomavirus type 10 genomic DNA, Human papillomavirus type 16, Human papillomavirus type 26, Human papillomavirus type 30 genomic DNA, Human papillomavirus type 32, Human papillomavirus type 34, Human papillomavirus type 41, Human papillomavirus type 48, Human papillomavirus type 49, Human papillomavirus type 50, Human papillomavirus type 53, Human papillomavirus type 60, Human papillomavirus type 63, Human papillomavirus type 71 DNA, Human papillomavirus type 85 isolate 114B, Human papillomavirus type 88, Human papillomavirus type 90, Human papillomavirus type 92, Human papillomavirus type 96, Human papillomavirus type 101, Human papillomavirus type 103, Human papillomavirus type 108, Human papillomavirus type 109, Human papillomavirus type 112, Human papillomavirus type 121, Human papillomavirus type 126, Human papillomavirus type 128, Human papillomavirus type 129, Human papillomavirus type 131, Human papillomavirus type 132, Human papillomavirus type 134, Human papillomavirus type 135, Human papillomavirus type 136, Human papillomavirus type 137, Human papillomavirus type 140, Human papillomavirus type 144, Human papillomavirus type 154 isolate PV77, Human papillomavirus type 156 isolate GC01, Human papillomavirus type 161 isolate KCl, Human papillomavirus type 163 isolate KC3, Human papillomavirus type 166 isolate KC9, Human papillomavirus type 167 isolate KC10, Human papillomavirus type 172, Human papillomavirus type 175 isolate SE87, Human, apillomavirus type 178, Human papillomavirus type 179 isolate SIBX16, Human papillomavirus type 184 isolate SIBX17, Human papillomavirus type 187 isolate ACS447, Human papillomavirus type 201 isolate HPV201, Human papillomavirus type 204 isolate A342, Human papillomoavirus type 5, Human parainfluenza virus 1, Human parainfluenza virus 3, Human rhinovirus 1 strain ATCC VR-1559, Human rhinovirus 3, Human rhinovirus 14, Human rhinovirus 89, Human rhinovirus C, Human rhinovirus NAT001 polyprotein gene, complete cds, Human T-lymphotropic virus 1, Influenza A virus (A/California/07/2009(H1N1)) segment 1 polymerase PB2 (PB2) gene, complete cds, Influenza A virus (A/California/07/2009(H1N1)) segment 2 polymerase PB1 (PB1) gene, complete cds; and nonfunctional PB1-F2 protein (PB1-F2) gene, Influenza A virus (A/California/07/2009(H1N1)) segment 3 polymerase PA (PA) gene, complete cds, Influenza A virus (A/California/07/2009(H1N1)) segment 4 hemagglutinin (HA) gene, complete cds, Influenza A virus (A/California/07/2009(H1N1)) segment 5 nucleocapsid protein (NP) gene, complete cds, Influenza A virus (A/California/07/2009(H1N1)) segment 6 neuraminidase (NA) gene, complete cds, Influenza A virus (A/California/07/2009(H1N1)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes, complete cds, Influenza A virus (A/California/07/2009(H1N1)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes, complete cds, Influenza A virus (A/Goose/Guangdong/1/96(H5N1)) neuraminidase (NA) gene, complete cds, Influenza A virus (A/Goose/Guangdong/1/96(H5N1)) nucleocapsid protein (NP) gene, complete cds, Influenza A virus (A/Goose/Guangdong/1/96(H5N1)) polymerase (PB2) gene, complete cds, Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) hemagglutinin (HA) gene, complete cds, Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) polymerase (PA) and PA-X protein (PA-X) genes, complete cds, Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) polymerase (PB1) and PB1-F2 protein (PB1-F2) genes, complete cds, Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) segment 7, Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) segment 8, Influenza A virus (A/Hong Kong/1073/99(H9N2)) segment 5, Influenza A virus (A/Hong Kong/1073/99(H9N2)) segment 7, Influenza A virus (A/Hong Kong/1073/99(H9N2)) segment 8, Influenza A virus (A/Korea/426/1968(H2N2)) segment 1, Influenza A virus (A/Korea/426/1968(H2N2)) segment 2, Influenza A virus (A/Korea/426/1968(H2N2)) segment 3, Influenza A virus (A/Korea/426/1968(H2N2)) segment 4, Influenza A virus (A/Korea/426/1968(H2N2)) segment 5, Influenza A virus (A/Korea/426/1968(H2N2)) segment 6, Influenza A virus (A/Korea/426/1968(H2N2)) segment 7, Influenza A virus (A/Korea/426/1968(H2N2)) segment 8, Influenza A virus (A/New York/392/2004(H3N2)) segment 1, Influenza A virus (A/New York/392/2004(H3N2)) segment 2, Influenza A virus (A/New York/392/2004(H3N2)) segment 3, Influenza A virus (A/New York/392/2004(H3N2)) segment 4, Influenza A virus (A/New York/392/2004(H3N2)) segment 5, Influenza A virus (A/New York/392/2004(H3N2)) segment 6, Influenza A virus (A/New York/392/2004(H3N2)) segment 7, Influenza A virus (A/New York/392/2004(H3N2)) segment 8, Influenza A virus (A/Puerto Rico/8/1934(H1N1)) segment 1, Influenza A virus (A/Puerto Rico/8/1934(H1N1)) segment 2, Influenza A virus (A/Puerto Rico/8/1934(H1N1)) segment 3, Influenza A virus (A/Puerto Rico/8/1934(H1N1)) segment 4, Influenza A virus (A/Puerto Rico/8/1934(H1N1)) segment 5, Influenza A virus (A/Puerto Rico/8/1934(H1N1)) segment 6, Influenza A virus (A/Puerto Rico/8/1934(H1N1)) segment 7, Influenza A virus (A/Puerto Rico/8/1934(H1N1)) segment 8, Influenza A virus (A/Shanghai/02/2013(H7N9)) segment 1 polymerase PB2 (PB2) gene, complete cds, Influenza A virus (A/Shanghai/02/2013(H7N9)) segment 2 polymerase PB1 (PB1) and PB1-F2 protein (PB1-F2) genes, complete cds, Influenza A virus (A/Shanghai/02/2013(H7N9)) segment 3 polymerase PA (PA) and PA-X protein (PA-X) genes, complete cds, Influenza A virus (A/Shanghai/02/2013(H7N9)) segment 4 hemagglutinin (HA) gene, complete cds, Influenza A virus (A/Shanghai/02/2013(H7N9)) segment 5 nucleocapsid protein (NP) gene, complete cds, Influenza A virus (A/Shanghai/02/2013(H7N9)) segment 6 neuraminidase (NA) gene, complete cds, Influenza A virus (A/Shanghai/02/2013(H7N9)) segment 7 matrix protein 2 (M2) and matrix protein 1 (M1) genes, complete cds, Influenza A virus (A/Shanghai/02/2013(H7N9)) segment 8 nuclear export protein (NEP) and nonstructural protein 1 (NS1) genes, complete cds, Influenza A virus ha gene for Hemagglutinin, genomic RNA, strain A/Hong Kong/1073/99(H9N2), Influenza A virus na gene for neuraminidase, genomic RNA, strain A/Hong Kong/1073/99(H9N2), Influenza A virus pa gene for polymerase PA, genomic RNA, strain A/Hong Kong/1073/99(H9N2), Influenza A virus pb1 gene for polymerase Pb1, genomic RNA, strain A/Hong Kong/1073/99(H9N2), Influenza A virus pb2 gene for polymerase Pb2, genomic RNA, strain A/Hong Kong/1073/99(H9N2), Influenza B virus (B/Lee/1940) segment 2, Influenza B virus (B/Lee/1940) segment 3, Influenza B virus (B/Lee/1940) segment 4, Influenza B virus (B/Lee/1940) segment 5, Influenza B virus (B/Lee/1940) segment 6, Influenza B virus (B/Lee/1940) segment 7, Influenza B virus (B/Lee/1940) segment 8, Influenza B virus RNA 1, Influenza C virus (C/Ann Arbor/1/50) HEF gene for hemagglutinin-esterase-fusion, complete cds, Influenza C virus (C/Ann Arbor/1/50) M1, CM2 genes for matrix protein, CM2 protein, complete cds, Influenza C virus (C/Ann Arbor/1/50) P3 gene for polymerase 3, complete cds, Influenza C virus (C/Ann Arbor/1/50) PB1 gene for polymerase 1, complete cds, Influenza C virus (C/Ann Arbor/1/50) PB2 gene for polymerase 2, complete cds, Influenza C virus (C/Ann Arbor/1/50) segment 5, Influenza C virus (C/Ann Arbor/1/50) segment 7, Neisseria gonorrhoeae strain WHO F chromosome 1, Respiratory syncytial virus, SARS coronavirus, or Streptococcus pyogenes strain NCTC8198 chromosome 1.

NASBA

In certain example embodiments, the RNA or DNA amplification is NASBA, which is initiated with reverse transcription of target RNA by a sequence-specific reverse primer to create a RNA/DNA duplex. RNase H is then used to degrade the RNA template, allowing a forward primer containing a promoter, such as the T7 promoter, to bind and initiate elongation of the complementary strand, generating a double-stranded DNA product. The RNA polymerase promoter-mediated transcription of the DNA template then creates copies of the target RNA sequence. Importantly, each of the new target RNAs can be detected by the guide RNAs thus further enhancing the sensitivity of the assay. Binding of the target RNAs by the guide RNAs then leads to activation of the CRISPR effector protein and the methods proceed as outlined above. The NASBA reaction has the additional advantage of being able to proceed under moderate isothermal conditions, for example at approximately 41° C., making it suitable for systems and devices deployed for early and direct detection in the field and far from clinical laboratories.

RPA

In certain other example embodiments, a recombinase polymerase amplification (RPA) reaction may be used to amplify the target nucleic acids. RPA reactions employ recombinases which are capable of pairing sequence-specific primers with homologous sequence in duplex DNA. If target DNA is present, DNA amplification is initiated and no other sample manipulation such as thermal cycling or chemical melting is required. The entire RPA amplification system is stable as a dried formulation and can be transported safely without refrigeration. RPA reactions may also be carried out at isothermal temperatures with an optimum reaction temperature of 37-42o C. The sequence specific primers are designed to amplify a sequence comprising the target nucleic acid sequence to be detected. In certain example embodiments, a RNA polymerase promoter, such as a T7 promoter, is added to one of the primers. This results in an amplified double-stranded DNA product comprising the target sequence and a RNA polymerase promoter. After, or during, the RPA reaction, a RNA polymerase is added that will produce RNA from the double-stranded DNA templates. The amplified target RNA can then in turn be detected by the CRISPR effector system. In this way target DNA can be detected using the embodiments disclosed herein. RPA reactions can also be used to amplify target RNA. The target RNA is first converted to cDNA using a reverse transcriptase, followed by second strand DNA synthesis, at which point the RPA reaction proceeds as outlined above.

Transposase Based Amplification

Embodiments disclosed herein provide systems and methods for isothermal amplification of target nucleic acid sequences by contacting oligonucleotides containing the target nucleic acid sequence with a transposon complex. The oligonucleotides may be single stranded or double stranded RNA, DNA, or RNA/DNA hybrid oligonucleotides. The transposon complex comprises a transposase and a transposon sequence comprising one or more RNA polymerase promoters. The transposase facilitates insertion of the one or more RNA polymerase promoters into the oligonucleotide. A RNA polymerase promoter can then transcribe the target nucleic acid sequence from the inserted one or more RNA polymerase promoters. One advantage of this system is that there is no need to heat or melt double-stranded DNA templates, since RNA polymerase polymerases require a double-stranded template. Such isothermal amplification is fast and simple, obviating the need for complicated and expensive instrumentation for denaturation and cooling. In certain example embodiment the RNA polymerase promoter is a native of modified T7 RNA promoter.

The term “transposon”, as used herein, refers to a nucleic acid segment, which is recognized by a transposase or an integrase enzyme and which is an essential component of a functional nucleic acid-protein complex (i.e. a transposome) capable of transposition. The term “transposase” as used herein refers to an enzyme, which is a component of a functional nucleic acid-protein complex capable of transposition and which is mediating transposition. The term “transposase” also refers to integrases from retrotransposons or of retroviral origin. Transposon complexes form between a transposase enzyme and a fragment of double stranded DNA that contains a specific binding sequence for the enzyme, termed “transposon end”. The sequence of the transposon binding site can be modified with other bases, at certain positions, without affecting the ability for transposon complex to form a stable structure that can efficiently transpose into target DNA.

In embodiments provided herein, the transposon complex may comprise a transposase and a transposon sequence comprising one or more RNA polymerase promoters. The term “promoter” refers to a region of DNA involved in binding the RNA polymerase to initiate transcription. In specific embodiments, the RNA polymerase promoter may be a T7 RNA polymerase promoter. The T7 RNA promoter may be inserted into the double-stranded polynucleotide using the transposase. In some embodiments, insertion of the T7 RNA polymerase promoter into the oligonucleotide may be random.

The frequency of transposition is very low for most transposons, which use complex mechanisms to limit activity. Tn5 transposase, for example, utilizes a DNA binding sequence that is suboptimal and the C-terminus of the transposase interferes with DNA binding. Mechanisms involved in Tn5 transposition have been carefully characterized by Reznikoff and colleagues. Tn5 transposes by a cut-and-paste mechanism. The transposon has two pairs of 19 bp elements that are utilized by the transposase: outside elements (OE) and inside elements (IE). One transposase monomer binds to each of the two elements that are utilized. After a monomer is bound to each end of the transposon, the two monomers dimerize, forming a synapse. Vectors with donor backbones of at least 200 bp, but less than 1000 bp, are most functional for transposition in bacteria. Transposon cleavage occurs by trans catalysis and only when monomers bound to each DNA end are in a synaptic complex. Tn5 transposes with a relaxed target site selection and can therefore insert into target DNA with little to no target sequence specificity.

The natural downregulation of Tn5 transposition can be overcome by selection of a hyperactive transposase and by optimizing the transposase-binding elements [Yorket al. 1998]. A mosaic element (ME), made by modification of three bases of the wild type OE, led to a 50-fold increase in transposition events in bacteria as well as cell-free systems. The combined effect of the optimized ME and hyperactive mutant transposase is estimated to result in a 100-fold increase in transposition activity. Goryshin et al showed that preformed Tn5 transposition complexes could be functionally introduced into bacterial or yeast by electroporation [Goryshin et al. 2000]. Linearization of the DNA, to have inverted repeats precisely positioned at both ends of the transposon, allowed Goryshin and coworkers to bypass the cutting step of transposition thus enhancing transposition efficiency.

In some embodiments, the transposase may be used to tagment the oligonucleotide sequence comprising the target sequence. The term “tagmentation” refers to a step in the Assay for Transposase Accessible Chromatin using sequencing (ATAC-seq) as described. (See, Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., Greenleaf, W. J., Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nature methods 2013; 10 (12): 1213-1218). Specifically, a hyperactive Tn5 transposase loaded in vitro with adapters for high-throughput DNA sequencing, can simultaneously fragment and tag a genome with sequencing adapters. In one embodiment the adapters are compatible with the methods described herein.

In some embodiments, the transposase may be a Tn5 transposase. In some embodiments, the transposase may be a variant of a Tn5 transposase, or an engineered transposase. Transposases may be engineered using any method known in the art. The engineered transposase may be optimized to function at a temperature ranging from 30° C. to 45° C., 35° C. to 40° C. or any temperature in between. The engineered transposase may be optimized to release from the oligonucleotide at a faster rate compared to a wild type transposase.

In some embodiments, the transposase may be a Tn5 transposase, a Mu transposase, or a Tn7 transposase. Transposition efficiency in vitro may vary depending on the transposon system used. Generally, Tn5 and Mu transposases effect higher levels of transposition efficiency. In some embodiments, insertion may be random. In some embodiments, insertion may occur in GC rich regions of the target sequence.

In some embodiments, the transposon sequence may comprise two 19 base pair Mosaic End (ME) Tn5 transposase recognition sequences. Tn5 transposases will generally transpose any DNA sequence contained between such short 19 base pair ME Tn5 transposase recognition sequences.

In some embodiments, use of a transposase allows for separation of a double-stranded polynucleotide in the absence of heat or melting. Embodiments can be as described in PCT/US2019/039195, entitled CRISPR/Cas and Transposase Based Amplification Compositions, Systems and Methods, incorporated herein by reference.

Nickase Dependent Amplification

In an embodiment of the invention may comprise nickase-based amplification. The nicking enzyme may be a CRISPR protein. Accordingly, the introduction of nicks into dsDNA can be programmable and sequence-specific. In an embodiment of the invention, two guides can be designed to target opposite strands of a dsDNA target. According to the invention, the nickase can be Cpf1, C2c1, Cas9 or any ortholog or CRISPR protein that cleaves or is engineered to cleave a single strand of a DNA duplex. The nicked strands may then be extended by a polymerase. In an embodiment, the locations of the nicks are selected such that extension of the strands by a polymerase is towards the central portion of the target duplex DNA between the nick sites. In certain embodiments, primers are included in the reaction capable of hybridizing to the extended strands followed by further polymerase extension of the primers to regenerate two dsDNA pieces: a first dsDNA that includes the first strand Cpf1 guide site or both the first and second strand Cpf1 guide sites, and a second dsDNA that includes the second strand Cpf1 guide site or both the first and second strand Cprf guide sites. These pieces continue to be nicked and extended in a cyclic reaction that exponentially amplifies the region of the target between nicking sites.

The amplification can be isothermal and selected for temperature. In one embodiment, the amplification proceeds rapidly at 37 degrees. In other embodiments, the temperature of the isothermal amplification may be chosen by selecting a polymerase (e.g. Bsu, Bst, Phi29, klenow fragment etc.) operable at a different temperature.

Thus, whereas nicking isothermal amplification techniques use nicking enyzmes with fixed sequence preference (e.g. in nicking enzyme amplification reaction or NEAR), which requires denaturing of the original dsDNA target to allow annealing and extension of primers that add the nicking substrate to the ends of the target, use of a CRISPR nickase wherein the nicking sites can be programed via guide RNAs means that no denaturing step is necessary, enabling the entire reaction to be truly isothermal. This also simplifies the reaction because these primers that add the nicking substrate are different than the primers that are used later in the reaction, meaning that NEAR requires two primer sets (i.e. 4 primers) while Cpf1 nicking amplification only requires one primer set (i.e. two primers). This makes nicking Cpf1 amplification much simpler and easier to operate without complicated instrumentation to perform the denaturation and then cooling to the isothermal temperature.

In an aspect, the isothermal amplification reagents may be utilized with a thermostable CRISPR-Cas protein. The combination of thermostable protein and isothermal amplification reagents may be utilized to further improve reaction times for detection and diagnostics.

Accordingly, in certain example embodiments the systems disclosed herein may include amplification reagents. Different components or reagents useful for amplification of nucleic acids are described herein. For example, an amplification reagent as described herein may include a buffer, such as a Tris buffer. A Tris buffer may be used at any concentration appropriate for the desired application or use, for example including, but not limited to, a concentration of 1 mM, 2 mM, 3 mM, 4 mM, 5 mM, 6 mM, 7 mM, 8 mM, 9 mM, 10 mM, 11 mM, 12 mM, 13 mM, 14 mM, 15 mM, 25 mM, 50 mM, 75 mM, 1 M, or the like. One of skill in the art will be able to determine an appropriate concentration of a buffer such as Tris for use with the present invention.

A salt, such as magnesium chloride (MgCl2), potassium chloride (KCl), or sodium chloride (NaCl), may be included in an amplification reaction, such as PCR, in order to improve the amplification of nucleic acid fragments. Although the salt concentration will depend on the particular reaction and application, in some embodiments, nucleic acid fragments of a particular size may produce optimum results at particular salt concentrations. Larger products may require altered salt concentrations, typically lower salt, in order to produce desired results, while amplification of smaller products may produce better results at higher salt concentrations. One of skill in the art will understand that the presence and/or concentration of a salt, along with alteration of salt concentrations, may alter the stringency of a biological or chemical reaction, and therefore any salt may be used that provides the appropriate conditions for a reaction of the present invention and as described herein. In certain preferred embodiments, when polynucleotide extraction beads such as magnetic beads are utilized, a Plant QuickExtract solution can be used in combination with a KCl buffer in optimized detection methods according to the present disclosure. Such a combination of beads and polynucleotide solutions in the one pot reactions provides methods for detecting without a separate extraction (extraction-free) step. The reagents and examples detailed herein further allow for the use of polynucleotide binding beads without additional step such as rinsing, with further efficencies in the reactions and sample processing, and permitting reduced operator time and laboratory resources.

Other components of a biological or chemical reaction may include a cell lysis component in order to break open or lyse a cell for analysis of the materials therein. A cell lysis component may include, but is not limited to, a detergent, a salt as described above, such as NaCl, KCl, ammonium sulfate [(NH4)2SO4], or others. Detergents that may be appropriate for the invention may include Triton X-100, sodium dodecyl sulfate (SDS), CHAPS (3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate), ethyl trimethyl ammonium bromide, nonyl phenoxypolyethoxylethanol (NP-40). Concentrations of detergents may depend on the particular application, and may be specific to the reaction in some cases. Amplification reactions may include dNTPs and nucleic acid primers used at any concentration appropriate for the invention, such as including, but not limited to, a concentration of 100 nM, 150 nM, 200 nM, 250 nM, 300 nM, 350 nM, 400 nM, 450 nM, 500 nM, 550 nM, 600 nM, 650 nM, 700 nM, 750 nM, 800 nM, 850 nM, 900 nM, 950 nM, 1 mM, 2 mM, 3 mM, 4 mM, 5 mM, 6 mM, 7 mM, 8 mM, 9 mM, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM, 60 mM, 70 mM, 80 mM, 90 mM, 100 mM, 150 mM, 200 mM, 250 mM, 300 mM, 350 mM, 400 mM, 450 mM, 500 mM, or the like. Likewise, a polymerase useful in accordance with the invention may be any specific or general polymerase known in the art and useful or the invention, including Taq polymerase, Q5 polymerase, or the like.

In some embodiments, amplification reagents as described herein may be appropriate for use in hot-start amplification. Hot start amplification may be beneficial in some embodiments to reduce or eliminate dimerization of adaptor molecules or oligos, or to otherwise prevent unwanted amplification products or artifacts and obtain optimum amplification of the desired product. Many components described herein for use in amplification may also be used in hot-start amplification. In some embodiments, reagents or components appropriate for use with hot-start amplification may be used in place of one or more of the composition components as appropriate. For example, a polymerase or other reagent may be used that exhibits a desired activity at a particular temperature or other reaction condition. In some embodiments, reagents may be used that are designed or optimized for use in hot-start amplification, for example, a polymerase may be activated after transposition or after reaching a particular temperature. Such polymerases may be antibody-based or aptamer-based. Polymerases as described herein are known in the art. Examples of such reagents may include, but are not limited to, hot-start polymerases, hot-start dNTPs, and photo-caged dNTPs. Such reagents are known and available in the art. One of skill in the art will be able to determine the optimum temperatures as appropriate for individual reagents.

Amplification of nucleic acids may be performed using specific thermal cycle machinery or equipment, and may be performed in single reactions or in bulk, such that any desired number of reactions may be performed simultaneously. In some embodiments, amplification may be performed using microfluidic or robotic devices, or may be performed using manual alteration in temperatures to achieve the desired amplification. In some embodiments, optimization may be performed to obtain the optimum reactions conditions for the particular application or materials. One of skill in the art will understand and be able to optimize reaction conditions to obtain sufficient amplification.

In certain embodiments, detection of DNA with the methods or systems of the invention requires transcription of the (amplified) DNA into RNA prior to detection.

It will be evident that detection methods of the invention can involve nucleic acid amplification and detection procedures in various combinations. The nucleic acid to be detected can be any naturally occurring or synthetic nucleic acid, including but not limited to DNA and RNA, which may be amplified by any suitable method to provide an intermediate product that can be detected. Detection of the intermediate product can be by any suitable method including but not limited to binding and activation of a CRISPR protein which produces a detectable signal moiety by direct or collateral activity.

Helicase-Dependent Amplification

In helicase-dependent amplification, a helicase enzyme is used to unwind a double stranded nucleic acid to generate templates for primer hybridization and subsequent primer-extension. This process utilizes two oligonucleotide primers, each hybridizing to the 3′-end of either the sense strand containing the target sequence or the anti-sense strand containing the reverse-complementary target sequence. The HDA reaction is a general method for helicase-dependent nucleic acid amplification.

In combining this method with a CRISPR-SHERLOCK system, the target nucleic acid may be amplified by opening R-loops of the target nucleic acid using first and second CRISPR/Cas complexes. The first and second strand of the target nucleic acid may thus be unwound using a helicase, allowing primers and polymerase to bind and extend the DNA under isothermal conditions.

The term “helicase” refers here to any enzyme capable of unwinding a double stranded nucleic acid enzymatically. For example, helicases are enzymes that are found in all organisms and in all processes that involve nucleic acid such as replication, recombination, repair, transcription, translation and RNA splicing. (Kornberg and Baker, DNA Replication, W. H. Freeman and Company (2nd ed. (1992)), especially chapter 11). Any helicase that translocates along DNA or RNA in a 5′ to 3′ direction or in the opposite 3′ to 5′ direction may be used in present embodiments of the invention. This includes helicases obtained from prokaryotes, viruses, archaea, and eukaryotes or recombinant forms of naturally occurring enzymes as well as analogues or derivatives having the specified activity. Examples of naturally occurring DNA helicases, described by Kornberg and Baker in chapter 11 of their book, DNA Replication, W. H. Freeman and Company (2^(nd) ed. (1992)), include E. coli helicase I, II, III, & IV, Rep, DnaB, PriA, PcrA, T4 Gp4lhelicase, T4 Dda helicase, T7 Gp4 helicases, SV40 Large T antigen, yeast RAD. Additional helicases that may be useful in HDA include RecQ helicase (Harmon and Kowalczykowski, J. Biol. Chem. 276:232-243 (2001)), thermostable UvrD helicases from T. tengcongensis (disclosed in this invention, Example XII) and T. thermophilus (Collins and McCarthy, Extremophiles. 7:35-41. (2003)), thermostable DnaB helicase from T. aquaticus (Kaplan and Steitz, J. Biol. Chem. 274:6889-6897 (1999)), and MCM helicase from archaeal and eukaryotic organisms ((Grainge et al., Nucleic Acids Res. 31:4888-4898 (2003)).

A traditional definition of a helicase is an enzyme that catalyzes the reaction of separating/unzipping/unwinding the helical structure of nucleic acid duplexes (DNA, RNA or hybrids) into single-stranded components, using nucleoside triphosphate (NTP) hydrolysis as the energy source (such as ATP). However, it should be noted that not all helicases fit this definition anymore. A more general definition is that they are motor proteins that move along the single-stranded or double stranded nucleic acids (usually in a certain direction, 3′ to 5′ or 5 to 3, or both), i.e. translocases, that can or cannot unwind the duplexed nucleic acid encountered. In addition, some helicases simply bind and “melt” the duplexed nucleic acid structure without an apparent translocase activity.

Helicases exist in all living organisms and function in all aspects of nucleic acid metabolism. Helicases are classified based on the amino acid sequences, directionality, oligomerization state and nucleic-acid type and structure preferences. The most common classification method was developed based on the presence of certain amino acid sequences, called motifs. According to this classification helicases are divided into 6 super families: SF1, SF2, SF3, SF4, SF5 and SF6. SF1 and SF2 helicases do not form a ring structure around the nucleic acid, whereas SF3 to SF6 do. Superfamily classification is not dependent on the classical taxonomy.

DNA helicases are responsible for catalyzing the unwinding of double-stranded DNA (dsDNA) molecules to their respective single-stranded nucleic acid (ssDNA) forms. Although structural and biochemical studies have shown how various helicases can translocate on ssDNA directionally, consuming one ATP per nucleotide, the mechanism of nucleic acid unwinding and how the unwinding activity is regulated remains unclear and controversial (T. M. Lohman, E. J. Tomko, C. G. Wu, “Non-hexameric DNA helicases and translocases: mechanisms and regulation,” Nat Rev Mol Cell Biol 9:391-401 (2008)). Since helicases can potentially unwind all nucleic acids encountered, understanding how their unwinding activities are regulated can lead to harnessing helicase functions for biotechnology applications.

The term “HDA” refers to Helicase Dependent Amplification, which is an in vitro method for amplifying nucleic acids by using a helicase preparation for unwinding a double stranded nucleic acid to generate templates for primer hybridization and subsequent primer-extension. This process utilizes two oligonucleotide primers, each hybridizing to the 3′-end of either the sense strand containing the target sequence or the anti-sense strand containing the reverse-complementary target sequence. The HDA reaction is a general method for helicase-dependent nucleic acid amplification.

The invention comprises use of any suitable helicase known in the art. These include, but are not necessarily limited to, UvrD helicase, CRISPR-Cas3 helicase, E. coli helicase I, E. coli helicase II, E. coli helicase III, E. coli helicase IV, Rep helicase, DnaB helicase, PriA helicase, PcrA helicase, T4 Gp41 helicase, T4 Dda helicase, SV40 Large T antigen, yeast RAD helicase, RecD helicase, RecQ helicase, thermostable T. tengcongensis UvrD helicase, thermostable T. thermophilus UvrD helicase, thermostable T. aquaticus DnaB helicase, Dda helicase, papilloma virus E1 helicase, archaeal MCM helicase, eukaryotic MCM helicase, and T7 Gp4 helicase.

In particularly preferred embodiments, the helicase comprises a super mutation. In particular embodiments, although the E. coli mutation has been described, the mutations were generated by sequence alignment (e.g. D409A/D410A for TteUvrd) and result in thermophilic enzymes working at lower temperatures like 37° C., which is advantageous for amplification methods and systems described herein. In some embodiments, the super mutations is an aspartate to alanine mutation, with position based on sequence alignment. In some embodiments, the super mutant helicase is selected from WP_003870487.1 Thermoanaerobacter ethanolicus 403/404, WP_049660019.1 Bacillus sp. FJAT-27231 407/408, WP_034654680.1 Bacillus megaterium 415/416, WP_095390358.1 Bacillus simplex 407/408, and WP_055343022.1 Paeniclostridium sordellii 402/403.

Incubating

Methods of detection and/or extraction using the systems disclosed herein can comprise incubating the sample or set of samples under conditions sufficient to allow binding of the guide RNAs to one or more target molecules. Exstraction can comprise incubating the sample under conditions sufficient to allow release of viral RNA present in the sample, which may comprise incubating at 22° C. to 60° C. for 30 to 70 minutes or at 90° C.-100° C. for about 10 minutes.

In certain example embodiments, the incubation time of the amplifying and detecting in the present invention may be shortened. The assay may be performed in a period of time required for an enzymatic reaction to occur. One skilled in the art can perform biochemical reactions in 5 minutes (e.g., 5 minute ligation). Incubating may occur at one or more temperatures over timeframes between about 10 minutes and 90 minutes, preferably less than 90 minutes, 75 minutes, 60 minutes, 45 minutes, 30 minutes, 25 minutes, 20 minutes, 15 minutes, or 10 minutes depending on sample, reagents and components of the system. In some embodiments, incubating for the amplification is performed at one or more temperatures between about 20° C. and 80° C., in some embodiments, about 37° C. In some embodiments, incubating for the amplification is performed at one or more temperatures between about 55° C. and 65° C., between about 59° C. and 61° C., in some embodiments, about 60° C.

Activating

In certain example embodiment, activating of the Cas protein occurs via binding of the CRISPR-Cas complex via the guide molecule to the one or more target molecules, wherein activating the CRISPR effector protein results in modification of the detection construct such that a detectable positive signal is generated.

Detecting a Signal

Detecting may comprise visual observance of a positive signal relative to a control. Detecting may comprise a loss of signal or presence of signal at one or more capture regions, for example colorimetric detection, or fluorescent detection. In certain example embodiments, further modifications may be introduced that further amplify the detectable positive signal. For example, activated CRISPR effector protein collateral activation may be used to generate a secondary target or additional guide sequence, or both. In one example embodiment, the reaction solution would contain a secondary target that is spiked in at high concentration. The secondary target may be distinct from the primary target (i.e. the target for which the assay is designed to detect) and in certain instances may be common across all reaction volumes. A secondary guide sequence for the secondary target may be protected, e.g. by a secondary structural feature such as a hairpin with an RNA loop, and unable to bind the second target or the CRISPR effector protein. Cleavage of the protecting group by an activated CRISPR effector protein (i.e. after activation by formation of complex with the primary target(s) in solution) and formation of a complex with free CRISPR effector protein in solution and activation from the spiked in secondary target. In certain other example embodiments, a similar concept is used with free guide sequence to a secondary target and protected secondary target. Cleavage of a protecting group off the secondary target would allow additional CRISPR effector protein, guide sequence, secondary target sequence to form. In yet another example embodiment, activation of CRISPR effector protein by the primary target(s) may be used to cleave a protected or circularized primer, which would then be released to perform an isothermal amplification reaction, such as those disclosed herein, on a template for either secondary guide sequence, secondary target, or both. Subsequent transcription of this amplified template would produce more secondary guide sequence and/or secondary target sequence, followed by additional CRISPR effector protein collateral activation.

Quantifying

In particular methods, comparing the intensity of the one or more signals to a control is performed to quantify the nucleic acid in the sample. The term “control” refers to any reference standard suitable to provide a comparison to the expression products in the test sample. In one embodiment, the control comprises obtaining a “control sample” from which expression product levels are detected and compared to the expression product levels from the test sample. Such a control sample may comprise any suitable sample, including but not limited to a sample from a control patient (can be stored sample or previous sample measurement) with a known outcome; normal tissue, fluid, or cells isolated from a subject, such as a normal patient or the patient having a condition of interest.

The intensity of a signal is “significantly” higher or lower than the normal intensity if the signal is greater or less, respectively, than the normal or control level by an amount greater than the standard error of the assay employed to assess amount, and preferably at least 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 300%, 350%, 400%, 500%, 600%, 700%, 800%, 900%, 1000% or than that amount. Alternatively, the signal can be considered “significantly” higher or lower than the normal and/or control signal if the amount is at least about two, and preferably at least about 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 100%, 105%, 110%, 115%, 120%, 125%, 130%, 135%, 140%, 145%, 150%, 155%, 160%, 165%, 170%, 175%, 180%, 185%, 190%, 195%, two times, three times, four times, five times, or more, or any range in between, such as 5%-100%, higher or lower, respectively, than the normal and/or control signal. Such significant modulation values can be applied to any metric described herein, such as altered level of expression, altered activity, changes in biomarker inhibition, changes in test agent binding, and the like.

In some embodiments, the detectable positive signal may be a loss of fluorescent signal or colorimetric relative to a control, as described herein. In some embodiments, the detectable positive signal may be detected on a lateral flow device, as described herein.

Applications of Detection Methods

Systems and methods can be designed for the detection and diagnosis of microbes, including bacterial, fungi and viral microbes. In an aspect, the systems may comprise multiplex detection of multiple variants of viral infections, including coronavirus, different viruses which may be related coronaviruses or respiratory viruses, or a combination thereof. In embodiments, assays can be performed for a variety of viruses and viral infections, including acute respiratory infections using the disclosure detailed herein. The systems can comprise two or more CRISPR Cas systems to multiplex, as described elsewhere herein, to detect a plurality of respiratory infections or viral infections, including coronavirus. The coronavirus is a positive-sense single stranded RNA family of viruses, infecting a variety of animals and humans. SARS-CoV is one type of coronavirus infection, as well as MERS-CoV Detection of one or more coronaviruses are envisioned, including the 2019-nCoV detected in Wuhan City. Sequences of the 2019-nCoV are available at GISAID accession no. EPI_ISL_402124 and EPI_ISL_402127-402130, and described in DOI: 10.1101/2020.01.22.914952. Further deposits of the SARS-CoV-2 deposited in the GISAID platform include EP_ISL_402119-402121 and EP_ISL 402123-402124; see also GenBank Accession No. MN908947.3.

Target molecule detection can comprise two or more detection systems utilizing RNA targeting Cas effector proteins; DNA targeting Cas effector proteins, or a combination thereof. The RNA-targeting effector proteins may be a Cas13 protein, such as Cas13a, Cas13b, or Cas13c, including one of the thermostable Cas13a proteins described herein. The DNA-targeting effector protein may be a Type V protein, e.g. Cas12 protein such as Cpf1 and C2c1. The Cas protein may preferably be thermostable, such as BrCas12b or Aap Cas12b. Multiplexing systems can be designed such that different Cas proteins with different sequence specificities or other motif cutting preferences can be used, including, in certain embodiments, at least one Cas. thermostable protein described herein. See International Publication WO 2019/126577. Type VI and Type V Cas proteins are known to possess different cutting motif preferences. See Gootenberg et al. “Multiplexed and portable nucleic acid detection platform with Cas13b, Cas12a, and Csm6.” Science. Apr. 27, 2018, 360:439-444; International Publication WO 2019/051318. Thus, embodiments disclosed herein may further comprise multiplex embodiments comprising two or more Type VI Cas proteins with different cutting preferences, or one or more Type VI Cas proteins and one or more Type V Cas proteins.

Multiplex approaches and selection of Cas effector proteins can be as described in International Publication WO 2019/126577 at [0415]-[0416] and Examples 1-10, incorporated herein by reference. In certain example embodiments, the coronavirus assay comprises a Type VI Cas protein disclosed herein and guide molecule comprising a guide sequence configured to directed binding of the CRISPR-Cas complex to a target molecule and a labeled detection molecule (“RNA-based masking construct”). A multiplex embodiment can be designed to track one or more variants of coronavirus or one or more variants of coronavirus, including SARS-CoV-2, in combination with other viruses, for example, Human respiratory syncytial virus, Middle East respiratory syndrome (MERS) coronavirus, Severe acute respiratory syndrome-related (SARS) coronavirus, and influenza. In embodiments, assays can be done in multiplex to detect multiple variants of coronavirus, different viruses which may be related coronaviruses or respiratory viruses, or a combination thereof. In an aspect, each assay can take place in an individual discrete volume. An “individual discrete volume” is a discrete volume or discrete space, such as a container, receptacle, or other defined volume or space that can be defined by properties that prevent and/or inhibit migration of nucleic acids and reagents necessary to carry out the methods disclosed herein, for example a volume or space defined by physical properties such as walls, for example the walls of a well, tube, or a surface of a droplet, which may be impermeable or semipermeable, or as defined by other means such as chemical, diffusion rate limited, electro-magnetic, or light illumination, or any combination thereof. By “diffusion rate limited” (for example diffusion defined volumes) is meant spaces that are only accessible to certain molecules or reactions because diffusion constraints effectively defining a space or volume as would be the case for two parallel laminar streams where diffusion will limit the migration of a target molecule from one stream to the other. By “chemical” defined volume or space is meant spaces where only certain target molecules can exist because of their chemical or molecular properties, such as size, where for example gel beads may exclude certain species from entering the beads but not others, such as by surface charge, matrix size or other physical property of the bead that can allow selection of species that may enter the interior of the bead. By “electro-magnetically” defined volume or space is meant spaces where the electro-magnetic properties of the target molecules or their supports such as charge or magnetic properties can be used to define certain regions in a space such as capturing magnetic particles within a magnetic field or directly on magnets. By “optically” defined volume is meant any region of space that may be defined by illuminating it with visible, ultraviolet, infrared, or other wavelengths of light such that only target molecules within the defined space or volume may be labeled. One advantage to the used of non-walled, or semipermeable is that some reagents, such as buffers, chemical activators, or other agents maybe passed in Applicants' through the discrete volume, while other material, such as target molecules, maybe maintained in the discrete volume or space. Typically, a discrete volume will include a fluid medium, (for example, an aqueous solution, an oil, a buffer, and/or a media capable of supporting cell growth) suitable for labeling of the target molecule with the indexable nucleic acid identifier under conditions that permit labeling. Exemplary discrete volumes or spaces useful in the disclosed methods include droplets (for example, microfluidic droplets and/or emulsion droplets), hydrogel beads or other polymer structures (for example poly-ethylene glycol di-acrylate beads or agarose beads), tissue slides (for example, fixed formalin paraffin embedded tissue slides with particular regions, volumes, or spaces defined by chemical, optical, or physical means), microscope slides with regions defined by depositing reagents in ordered arrays or random patterns, tubes (such as, centrifuge tubes, microcentrifuge tubes, test tubes, cuvettes, conical tubes, and the like), bottles (such as glass bottles, plastic bottles, ceramic bottles, Erlenmeyer flasks, scintillation vials and the like), wells (such as wells in a plate), plates, pipettes, or pipette tips among others. In certain example embodiments, the individual discrete volumes are the wells of a microplate. In certain example embodiments, the microplate is a 96 well, a 384 well, or a 1536 well microplate.

In certain example embodiments, the systems, devices, and methods, disclosed herein are directed to detecting the presence of one or more microbial agents in a sample, such as a biological sample obtained from a subject. In certain example embodiments, the microbe may be a bacterium, a fungus, a yeast, a protozoan, a parasite, or a virus. Accordingly, the methods disclosed herein can be adapted for use in other methods (or in combination) with other methods that require quick identification of microbe species, monitoring the presence of microbial proteins (antigens), antibodies, antibody genes, detection of certain phenotypes (e.g. bacterial resistance), monitoring of disease progression and/or outbreak, and antibiotic screening. Because of the rapid and sensitive diagnostic capabilities of the embodiments disclosed here, detection of microbe species type, down to a single nucleotide difference, and the ability to be deployed as a POC device, the embodiments disclosed herein may be used as guide therapeutic regimens, such as a selection of the appropriate antibiotic or antiviral. The embodiments disclosed herein may also be used to screen environmental samples (air, water, surfaces, food etc.) for the presence of microbial contamination.

Disclosed is a method to identify microbial species, such as bacterial, viral, fungal, yeast, or parasitic species, or the like. Particular embodiments disclosed herein describe methods and systems that will identify and distinguish microbial species within a single sample, or across multiple samples, allowing for recognition of many different microbes. The present methods allow the detection of pathogens and distinguishing between two or more species of one or more organisms, e.g., bacteria, viruses, yeast, protozoa, and fungi or a combination thereof, in a biological or environmental sample, by detecting the presence of a target nucleic acid sequence in the sample. A positive signal obtained from the sample indicates the presence of the microbe. Multiple microbes can be identified simultaneously using the methods and systems of the invention, by employing the use of more than one effector protein, wherein each effector protein targets a specific microbial target sequence. In this way, a multi-level analysis can be performed for a particular subject in which any number of microbes can be detected at once, for example, a subject with unknown respiratory infection, having symptoms of coronavirus, or an individual at risk or having been exposed to coronavirus. In some embodiments, simultaneous detection of multiple microbes may be performed using a set of probes that can identify one or more microbial species.

Microbe Detection

In some embodiments, a method for detecting microbes in samples is provided comprising distributing a sample or set of samples into one or more individual discrete volumes, the individual discrete volumes comprising a CRISPR system as described herein; incubating the sample or set of samples under conditions sufficient to allow binding of the one or more guide RNAs to one or more microbe-specific targets; activating the CRISPR effector protein via binding of the one or more guide RNAs to the one or more target molecules, wherein activating the CRISPR effector protein results in modification of the RNA-based masking construct such that a detectable positive signal is generated; and detecting the detectable positive signal, wherein detection of the detectable positive signal indicates a presence of one or more target molecules in the sample. The one or more target molecules may be mRNA, gDNA (coding or non-coding), trRNA, or rRNA comprising a target nucleotide tide sequence that may be used to distinguish two or more microbial species/strains from one another. The guide RNAs may be designed to detect target sequences. The embodiments disclosed herein may also utilize certain steps to improve hybridization between guide RNA and target RNA sequences. Methods for enhancing ribonucleic acid hybridization are disclosed in WO 2015/085194, entitled “Enhanced Methods of Ribonucleic Acid Hybridization” which is incorporated herein by reference. The microbe-specific target may be RNA or DNA or a protein. If DNA method may further comprise the use of DNA primers that introduce a RNA polymerase promoter as described herein. If the target is a protein then the method will utilize aptamers and steps specific to protein detection described herein.

Detection of Single Nucleotide Variants

In some embodiments, one or more identified target sequences may be detected using guide RNAs that are specific for and bind to the target sequence as described herein. The systems and methods of the present invention can distinguish even between single nucleotide polymorphisms present among different microbial species and therefore, use of multiple guide RNAs in accordance with the invention may further expand on or improve the number of target sequences that may be used to distinguish between species. For example, in some embodiments, the one or more guide RNAs may distinguish between microbes at the species, genus, family, order, class, phylum, kingdom, or phenotype, or a combination thereof.

Detection Based on rRNA Sequences

In certain example embodiments, the devices, systems, and methods disclosed herein may be used to distinguish multiple microbial species in a sample. In certain example embodiments, identification may be based on ribosomal RNA sequences, including the 16S, 23S, and 5S subunits. Methods for identifying relevant rRNA sequences are disclosed in U.S. Patent Application Publication No. 2017/0029872. In certain example embodiments, a set of guide RNA may designed to distinguish each species by a variable region that is unique to each species or strain. Guide RNAs may also be designed to target RNA genes that distinguish microbes at the genus, family, order, class, phylum, kingdom levels, or a combination thereof. In certain example embodiments where amplification is used, a set of amplification primers may be designed to flanking constant regions of the ribosomal RNA sequence and a guide RNA designed to distinguish each species by a variable internal region. In certain example embodiments, the primers and guide RNAs may be designed to conserved and variable regions in the 16S subunit respectfully. Other genes or genomic regions that uniquely variable across species or a subset of species such as the RecA gene family, RNA polymerase β subunit, may be used as well. Other suitable phylogenetic markers, and methods for identifying the same, are discussed for example in Wu et al. arXiv:1307.8690 [q-bio.GN].

In certain example embodiments, a method or diagnostic is designed to screen microbes across multiple phylogenetic and/or phenotypic levels at the same time. For example, the method or diagnostic may comprise the use of multiple CRISPR systems with different guide RNAs. A first set of guide RNAs may distinguish, for example, between mycobacteria, gram positive, and gram-negative bacteria. These general classes can be even further subdivided. For example, guide RNAs could be designed and used in the method or diagnostic that distinguish enteric and non-enteric within gram negative bacteria. A second set of guide RNA can be designed to distinguish microbes at the genus or species level. Thus, a matrix may be produced identifying all mycobacteria, gram positive, gram negative (further divided into enteric and non-enteric) with each genus of species of bacteria identified in a given sample that fall within one of those classes. The foregoing is for example purposes only. Other means for classifying other microbe types are also contemplated and would follow the general structure described above.

Screening for Drug Resistance

In certain example embodiments, the devices, systems and methods disclosed herein may be used to screen for microbial genes of interest, for example antibiotic and/or antiviral resistance genes. Guide RNAs may be designed to distinguish between known genes of interest. Samples, including clinical samples, may then be screened using the embodiments disclosed herein for detection of such genes. The ability to screen for drug resistance at POC would have tremendous benefit in selecting an appropriate treatment regime. In certain example embodiments, the antibiotic resistance genes are carbapenemases including KPC, NDM1, CTX-M15, OXA-48. Other antibiotic resistance genes are known and may be found for example in the Comprehensive Antibiotic Resistance Database (Jia et al. “CARD 2017: expansion and model-centric curation of the Comprehensive Antibiotic Resistance Database.” Nucleic Acids Research, 45, D566-573).

Ribavirin is an effective antiviral that hits a number of RNA viruses. Several clinically important viruses have evolved ribavirin resistance including Foot and Mouth Disease Virus doi:10.1128/JVI.03594-13; polio virus (Pfeifer and Kirkegaard. PNAS, 100(12):7289-7294, 2003); and hepatitis C virus (Pfeiffer and Kirkegaard, J. Virol. 79(4):2346-2355, 2005). A number of other persistent RNA viruses, such as hepatitis and HIV, have evolved resistance to existing antiviral drugs: hepatitis B virus (lamivudine, tenofovir, entecavir) doi:10/1002/hep22900; hepatitis C virus (telaprevir, BILN2061, ITMN-191, SCh6, boceprevir, AG-021541, ACH-806) doi:10.1002/hep.22549; and HIV (many drug resistance mutations) hivb.standford.edu. The embodiments disclosed herein may be used to detect such variants among others.

Aside from drug resistance, there are a number of clinically relevant mutations that could be detected with the embodiments disclosed herein, such as persistent versus acute infection in LCMV (doi:10.1073/pnas.1019304108), and increased infectivity of Ebola (Diehl et al. Cell. 2016, 167(4):1088-1098.

As described herein elsewhere, closely related microbial species (e.g. having only a single nucleotide difference in a given target sequence) may be distinguished by introduction of a synthetic mismatch in the gRNA.

Monitoring Microbe Outbreaks

In some embodiments, a CRISPR system or methods of use thereof as described herein may be used to determine the evolution of a pathogen outbreak. The method may comprise detecting one or more target sequences from a plurality of samples from one or more subjects, wherein the target sequence is a sequence from a microbe causing the outbreaks. Such a method may further comprise determining a pattern of pathogen transmission, or a mechanism involved in a disease outbreak caused by a pathogen.

The pattern of pathogen transmission may comprise continued new transmissions from the natural reservoir of the pathogen or subject-to-subject transmissions (e.g. human-to-human transmission) following a single transmission from the natural reservoir or a mixture of both. In one embodiment, the pathogen transmission may be bacterial or viral transmission, in such case, the target sequence is preferably a microbial genome or fragments thereof. In one embodiment, the pattern of the pathogen transmission is the early pattern of the pathogen transmission, i.e. at the beginning of the pathogen outbreak. Determining the pattern of the pathogen transmission at the beginning of the outbreak increases likelihood of stopping the outbreak at the earliest possible time thereby reducing the possibility of local and international dissemination.

Determining the pattern of the pathogen transmission may comprise detecting a pathogen sequence according to the methods described herein. Determining the pattern of the pathogen transmission may further comprise detecting shared intra-host variations of the pathogen sequence between the subjects and determining whether the shared intra-host variations show temporal patterns. Patterns in observed intrahost and interhost variation provide important insight about transmission and epidemiology (Gire, et al., 2014).

Detection of shared intra-host variations between the subjects that show temporal patterns is an indication of transmission links between subject (in particular between humans) because it can be explained by subject infection from multiple sources (superinfection), sample contamination recurring mutations (with or without balancing selection to reinforce mutations), or co-transmission of slightly divergent viruses that arose by mutation earlier in the transmission chain (Park, et al., Cell 161(7):1516-1526, 2015). Detection of shared intra-host variations between subjects may comprise detection of intra-host variants located at common single nucleotide polymorphism (SNP) positions. Positive detection of intra-host variants located at common (SNP) positions is indicative of superinfection and contamination as primary explanations for the intra-host variants. Superinfection and contamination can be parted on the basis of SNP frequency appearing as inter-host variants (Park, et al., 2015). Otherwise superinfection and contamination can be ruled out. In this latter case, detection of shared intra-host variations between subjects may further comprise assessing the frequencies of synonymous and nonsynonymous variants and comparing the frequency of synonymous and nonsynonymous variants to one another. A nonsynonymous mutation is a mutation that alters the amino acid of the protein, likely resulting in a biological change in the microbe that is subject to natural selection. Synonymous substitution does not alter an amino acid sequence. Equal frequency of synonymous and nonsynonymous variants is indicative of the intra-host variants evolving neutrally. If frequencies of synonymous and nonsynonymous variants are divergent, the intra-host variants are likely to be maintained by balancing selection. If frequencies of synonymous and nonsynonymous variants are low, this is indicative of recurrent mutation. If frequencies of synonymous and nonsynonymous variants are high, this is indicative of co-transmission (Park, et al., 2015).

Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. Andersen et al. generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples (Andersen, et al., Cell Volume 162, Issue 4, p 738-750, 13 Aug. 2015). Andersen et al. show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. Andersen et al. elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. The method may further comprise phylogenetically comparing a first pathogen sequence to a second pathogen sequence, and determining whether there is a phylogenetic link between the first and second pathogen sequences. The second pathogen sequence may be an earlier reference sequence. If there is a phylogenetic link, the method may further comprise rooting the phylogeny of the first pathogen sequence to the second pathogen sequence. Thus, it is possible to construct the lineage of the first pathogen sequence. (Park, et al., 2015).

The method may further comprise determining whether the mutations are deleterious or adaptive. Deleterious mutations are indicative of transmission-impaired viruses and dead-end infections, thus normally only present in an individual subject. Mutations unique to one individual subject are those that occur on the external branches of the phylogenetic tree, whereas internal branch mutations are those present in multiple samples (i.e. in multiple subjects). Higher rate of nonsynonymous substitution is a characteristic of external branches of the phylogenetic tree (Park, et al., 2015).

In internal branches of the phylogenetic tree, selection has had more opportunity to filter out deleterious mutants. Internal branches, by definition, have produced multiple descendent lineages and are thus less likely to include mutations with fitness costs. Thus, lower rate of nonsynonymous substitution is indicative of internal branches (Park, et al., 2015).

Synonymous mutations, which likely have less impact on fitness, occurred at more comparable frequencies on internal and external branches (Park, et al., 2015).

By analyzing the sequenced target sequence, such as viral genomes, it is possible to discover the mechanisms responsible for the severity of the epidemic episode such as during the 2014 Ebola outbreak. For example, Gire et al. made a phylogenetic comparison of the genomes of the 2014 outbreak to all 20 genomes from earlier outbreaks suggests that the 2014 West African virus likely spread from central Africa within the past decade. Rooting the phylogeny using divergence from other ebolavirus genomes was problematic (6, 13). However, rooting the tree on the oldest outbreak revealed a strong correlation between sample date and root-to-tip distance, with a substitution rate of 8×10-4 per site per year (13). This suggests that the lineages of the three most recent outbreaks all diverged from a common ancestor at roughly the same time, around 2004, which supports the hypothesis that each outbreak represents an independent zoonotic event from the same genetically diverse viral population in its natural reservoir. They also found out that the 2014 EBOV outbreak might be caused by a single transmission from the natural reservoir, followed by human-to-human transmission during the outbreak. Their results also suggested that the epidemic episode in Sierra Leon might stem from the introduction of two genetically distinct viruses from Guinea around the same time (Gire, et al., 2014).

It has been also possible to determine how the Lassa virus spread out from its origin point, in particular thanks to human-to-human transmission and even retrace the history of this spread 400 years back (Andersen, et al., Cell 162(4):738-50, 2015).

In relation to the work needed during the 2013-2015 EBOV outbreak and the difficulties encountered by the medical staff at the site of the outbreak, and more generally, the method of the invention makes it possible to carry out sequencing using fewer selected probes such that sequencing can be accelerated, thus shortening the time needed from sample taking to results procurement. Further, kits and systems can be designed to be usable on the field so that diagnostics of a patient can be readily performed without need to send or ship samples to another part of the country or the world.

In any method described above, sequencing the target sequence or fragment thereof may be used any of the sequencing processes described above. Further, sequencing the target sequence or fragment thereof may be a near-real-time sequencing. Sequencing the target sequence or fragment thereof may be carried out according to previously described methods (Experimental Procedures: Matranga et al., 2014; and Gire, et al., 2014). Sequencing the target sequence or fragment thereof may comprise parallel sequencing of a plurality of target sequences. Sequencing the target sequence or fragment thereof may comprise Illumina sequencing.

Analyzing the target sequence or fragment thereof that hybridizes to one or more of the selected probes may be an identifying analysis, wherein hybridization of a selected probe to the target sequence or a fragment thereof indicates the presence of the target sequence within the sample.

Currently, primary diagnostics are based on the symptoms a patient has. However, various diseases may share identical symptoms so that diagnostics rely much on statistics. For example, malaria triggers flu-like symptoms: headache, fever, shivering, joint pain, vomiting, hemolytic anemia, jaundice, hemoglobin in the urine, retinal damage, and convulsions. These symptoms are also common for septicemia, gastroenteritis, and viral diseases. Amongst the latter, Ebola hemorrhagic fever has the following symptoms fever, sore throat, muscular pain, headaches, vomiting, diarrhea, rash, decreased function of the liver and kidneys, internal and external hemorrhage.

When a patient is presented to a medical unit, for example in tropical Africa, basic diagnostics will conclude to malaria because statistically, malaria is the most probable disease within that region of Africa. The patient is consequently treated for malaria although the patient might not actually have contracted the disease and the patient ends up not being correctly treated. This lack of correct treatment can be life-threatening especially when the disease the patient contracted presents a rapid evolution. It might be too late before the medical staff realizes that the treatment given to the patient is ineffective and comes to the correct diagnostics and administers the adequate treatment to the patient.

The method of the invention provides a solution to this situation. Indeed, because the number of guide RNAs can be dramatically reduced, this makes it possible to provide on a single chip selected probes divided into groups, each group being specific to one disease, such that a plurality of diseases, e.g. viral infection, can be diagnosed at the same time. Thanks to the invention, more than 3 diseases can be diagnosed on a single chip, preferably more than 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 diseases at the same time, preferably the diseases that most commonly occur within the population of a given geographical area. Since each group of selected probes is specific to one of the diagnosed diseases, a more accurate diagnosis can be performed, thus diminishing the risk of administering the wrong treatment to the patient.

In other cases, a disease such as a viral infection may occur without any symptoms, or had caused symptoms but they faded out before the patient is presented to the medical staff. In such cases, either the patient does not seek any medical assistance or the diagnostics is complicated due to the absence of symptoms on the day of the presentation.

The present invention may also be used in concert with other methods of diagnosing disease, identifying pathogens and optimizing treatment based upon detection of nucleic acids, such as mRNA in crude, non-purified samples.

The method of the invention also provides a powerful tool to address this situation. Indeed, since a plurality of groups of selected guide RNAs, each group being specific to one of the most common diseases that occur within the population of the given area, are comprised within a single diagnostic, the medical staff only need to contact a biological sample taken from the patient with the chip. Reading the chip reveals the diseases the patient has contracted.

In some cases, the patient is presented to the medical staff for diagnostics of particular symptoms. The method of the invention makes it possible not only to identify which disease causes these symptoms but at the same time determine whether the patient suffers from another disease he was not aware of.

This information might be of utmost importance when searching for the mechanisms of an outbreak. Indeed, groups of patients with identical viruses also show temporal patterns suggesting a subject-to-subject transmission links.

Example Microbes

The embodiment disclosed herein may be used to detect a number of different microbes. The term microbe as used herein includes bacteria, fungus, protozoa, parasites and viruses.

Bacteria

The following provides an example list of the types of microbes that might be detected using the embodiments disclosed herein. In certain example embodiments, the microbe is a bacterium. Examples of bacteria that can be detected in accordance with the disclosed methods include without limitation any one or more of (or any combination of) Acinetobacter baumanii, Actinobacillus sp., Actinomycetes, Actinomyces sp. (such as Actinomyces israelii and Actinomyces naeslundii), Aeromonas sp. (such as Aeromonas hydrophila, Aeromonas veronii biovar sobria (Aeromonas sobria), and Aeromonas caviae), Anaplasma phagocytophilum, Anaplasma marginate Alcaligenes xylosoxidans, Acinetobacter baumanii, Actinobacillus actinomycetemcomitans, Bacillus sp. (such as Bacillus anthracis, Bacillus cereus, Bacillus subtilis, Bacillus thuringiensis, and Bacillus stearothermophilus), Bacteroides sp. (such as Bacteroides Bartonella sp. (such as Bartonella bacilliformis and Bartonella henselae, Bifidobacterium sp., Bordetella sp. (such as Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica), Borrelia sp. (such as Borrelia recurrentis, and Borrelia burgdorferi), Brucella sp. (such as Brucella abortus, Brucella canis, Brucella melintensis and Brucella suis), Burkholderia sp. (such as Burkholderia pseudomallei and Burkholderia cepacia), Campylobacter sp. (such as Campylobacter jejuni, Campylobacter coli, Campylobacter lari and Campylobacter fetus), Capnocytophaga sp., Cardiobacterium hominis, Chlamydia trachomatis, Chlamydophila pneumoniae, Chlamydophila psittaci, Citrobacter sp. Coxiella burnetii, Corynebacterium sp. (such as, Corynebacterium diphtheriae, Corynebacterium jeikeum and Corynebacterium), Clostridium sp. (such as Clostridium perfringens, Clostridium difficile, Clostridium botulinum and Clostridium tetani), Eikenella corrodens, Enterobacter sp. (such as Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae and Escherichia coli, including opportunistic Escherichia coli, such as enterotoxigenic E. coli, enteroinvasive E. coli, enteropathogenic E. coli, enterohemorrhagic E. coli, enteroaggregative E. coli and uropathogenic E. coli) Enterococcus sp. (such as Enterococcus faecalis and Enterococcus faecium) Ehrlichia sp. (such as Ehrlichia chafeensia and Ehrlichia canis), Epidermophyton floccosum, Erysipelothrix rhusiopathiae, Eubacterium sp., Francisella tularensis, Fusobacterium nucleatum, Gardnerella vaginalis, Gemella morbillorum, Haemophilus sp. (such as Haemophilus influenzae, Haemophilus ducreyi, Haemophilus aegyptius, Haemophilus parainfluenzae, Haemophilus haemolyticus and Haemophilus parahaemolyticus, Helicobacter sp. (such as Helicobacter pylori, Helicobacter cinaedi and Helicobacter fennelliae), Kingella kingii, Klebsiella sp. (such as Klebsiella pneumoniae, Klebsiella granulomatis and Klebsiella oxytoca), Lactobacillus sp., Listeria monocytogenes, Leptospira interrogans, Legionella pneumophila, Leptospira interrogans, Peptostreptococcus sp., Mannheimia hemolytica, Microsporum canis, Moraxella catarrhalis, Morganella sp., Mobiluncus sp., Micrococcus sp., Mycobacterium sp. (such as Mycobacterium leprae, Mycobacterium tuberculosis, Mycobacterium paratuberculosis, Mycobacterium intracellulare, Mycobacterium avium, Mycobacterium bovis, and Mycobacterium marinum), Mycoplasm sp. (such as Mycoplasma pneumoniae, Mycoplasma hominis, and Mycoplasma genitalium), Nocardia sp. (such as Nocardia asteroides, Nocardia cyriacigeorgica and Nocardia brasiliensis), Neisseria sp. (such as Neisseria gonorrhoeae and Neisseria meningitidis), Pasteurella multocida, Pityrosporum orbiculare (Malassezia furfur), Plesiomonas shigelloides. Prevotella sp., Porphyromonas sp., Prevotella melaninogenica, Proteus sp. (such as Proteus vulgaris and Proteus mirabilis), Providencia sp. (such as Providencia alcalifaciens, Providencia rettgeri and Providencia stuartii), Pseudomonas aeruginosa, Propionibacterium acnes, Rhodococcus equi, Rickettsia sp. (such as Rickettsia rickettsii, Rickettsia akari and Rickettsia prowazekii, Orientia tsutsugamushi (formerly: Rickettsia tsutsugamushi) and Rickettsia typhi), Rhodococcus sp., Serratia marcescens, Stenotrophomonas maltophilia, Salmonella sp. (such as Salmonella enterica, Salmonella typhi, Salmonella paratyphi, Salmonella enteritidis, Salmonella cholerasuis and Salmonella typhimurium), Serratia sp. (such as Serratia marcesans and Serratia liquifaciens), Shigella sp. (such as Shigella dysenteriae, Shigella flexneri, Shigella boydii and Shigella sonnei), Staphylococcus sp. (such as Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hemolyticus, Staphylococcus saprophyticus), Streptococcus sp. (such as Streptococcus pneumoniae (for example chloramphenicol-resistant serotype 4 Streptococcus pneumoniae, spectinomycin-resistant serotype 6B Streptococcus pneumoniae, streptomycin-resistant serotype 9V Streptococcus pneumoniae, erythromycin-resistant serotype 14 Streptococcus pneumoniae, optochin-resistant serotype 14 Streptococcus pneumoniae, rifampicin-resistant serotype 18C Streptococcus pneumoniae, tetracycline-resistant serotype 19F Streptococcus pneumoniae, penicillin-resistant serotype 19F Streptococcus pneumoniae, and trimethoprim-resistant serotype 23F Streptococcus pneumoniae, chloramphenicol-resistant serotype 4 Streptococcus pneumoniae, spectinomycin-resistant serotype 6B Streptococcus pneumoniae, streptomycin-resistant serotype 9V Streptococcus pneumoniae, optochin-resistant serotype 14 Streptococcus pneumoniae, rifampicin-resistant serotype 18C Streptococcus pneumoniae, penicillin-resistant serotype 19F Streptococcus pneumoniae, or trimethoprim-resistant serotype 23F Streptococcus pneumoniae), Streptococcus agalactiae, Streptococcus mutans, Streptococcus pyogenes, Group A streptococci, Streptococcus pyogenes, Group B streptococci, Streptococcus agalactiae, Group C streptococci, Streptococcus anginosus, Streptococcus equismilis, Group D streptococci, Streptococcus bovis, Group F streptococci, and Streptococcus anginosus Group G streptococci), Spirillum minus, Streptobacillus moniliformi, Treponema sp. (such as Treponema carateum, Treponema petenue, Treponema pallidum and Treponema endemicum, Trichophyton rubrum, T mentagrophytes, Tropheryma whippelii, Ureaplasma urealyticum, Veillonella sp., Vibrio sp. (such as Vibrio cholerae, Vibrio parahemolyticus, Vibrio vulnificus, Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio alginolyticus, Vibrio mimicus, Vibrio hollisae, Vibrio fluvialis, Vibrio metchnikovii, Vibrio damsela and Vibrio furnisii), Yersinia sp. (such as Yersinia enterocolitica, Yersinia pestis, and Yersinia pseudotuberculosis) and Xanthomonas maltophilia among others.

Fungi

In certain example embodiments, the microbe is a fungus or a fungal species. Examples of fungi that can be detected in accordance with the disclosed methods include without limitation any one or more of (or any combination of), Aspergillus, Blastomyces, Candidiasis, Coccidiodomycosis, Cryptococcus neoformans, Cryptococcus gatti, sp. Histoplasma sp. (such as Histoplasma capsulatum), Pneumocystis sp. (such as Pneumocystis jirovecii), Stachybotrys (such as Stachybotrys chartarum), Mucroymcosis, Sporothrix, fungal eye infections ringworm, Exserohilum, Cladosporium.

In certain example embodiments, the fungus is a yeast. Examples of yeast that can be detected in accordance with disclosed methods include without limitation one or more of (or any combination of), Aspergillus species (such as Aspergillus fumigatus, Aspergillus flavus and Aspergillus clavatus), Cryptococcus sp. (such as Cryptococcus neoformans, Cryptococcus gattii, Cryptococcus laurentii and Cryptococcus albidus), a Geotrichum species, a Saccharomyces species, a Hansenula species, a Candida species (such as Candida albicans), a Kluyveromyces species, a Debaryomyces species, a Pichia species, or combination thereof. In certain example embodiments, the fungi is a mold. Example molds include, but are not limited to, a Penicillium species, a Cladosporium species, a Byssochlamys species, or a combination thereof.

Protozoa

In certain example embodiments, the microbe is a protozoa. Examples of protozoa that can be detected in accordance with the disclosed methods and devices include without limitation any one or more of (or any combination of), Euglenozoa, Heterolobosea, Diplomonadida, Amoebozoa, Blastocystic, and Apicomplexa. Example Euglenoza include, but are not limited to, Trypanosoma cruzi (Chagas disease), T. brucei gambiense, T. brucei rhodesiense, Leishmania braziliensis, L. infantum, L. mexicana, L. major, L. tropica, and L. donovani. Example Heterolobosea include, but are not limited to, Naegleria fowleri. Example Diplomonadids include, but are not limited to, Giardia intestinalis (G. lamblia, G. duodenalis). Example Amoebozoa include, but are not limited to, Acanthamoeba castellanii, Balamuthia madrillaris, Entamoeba histolytica. Example Blastocysts include, but are not limited to, Blastocystic hominis. Example Apicomplexa include, but are not limited to, Babesia microti, Cryptosporidium parvum, Cyclospora cayetanensis, Plasmodium falciparum, P. vivax, P. ovale, P. malariae, and Toxoplasma gondii.

Parasites

In certain example embodiments, the microbe is a parasite. Examples of parasites that can be detected in accordance with disclosed methods include without limitation one or more of (or any combination of), an Onchocerca species and a Plasmodium species.

Viruses

In certain example embodiments, the systems, devices, and methods, disclosed herein are directed to detecting viruses in a sample. The embodiments disclosed herein may be used to detect viral infection (e.g. of a subject or plant), or determination of a viral strain, including viral strains that differ by a single nucleotide polymorphism. The virus may be a DNA virus, a RNA virus, or a retrovirus. Non-limiting example of viruses useful with the present invention include, but are not limited to Ebola, measles, SARS, Chikungunya, hepatitis, Marburg, yellow fever, MERS, Dengue, Lassa, influenza, rhabdovirus or HIV. A hepatitis virus may include hepatitis A, hepatitis B, or hepatitis C. An influenza virus may include, for example, influenza A or influenza B. An HIV may include HIV 1 or HIV 2. In certain example embodiments, the viral sequence may be a human respiratory syncytial virus, Sudan ebola virus, Bundibugyo virus, Tai Forest ebola virus, Reston ebola virus, Achimota, Aedes flavivirus, Aguacate virus, Akabane virus, Alethinophid reptarenavirus, Allpahuayo mammarenavirus, Amapari mmarenavirus, Andes virus, Apoi virus, Aravan virus, Aroa virus, Arumwot virus, Atlantic salmon paramyxovirus, Australian bat lyssavirus, Avian bornavirus, Avian metapneumovirus, Avian paramyxoviruses, penguin or Falkland Islandsvirus, BK polyomavirus, Bagaza virus, Banna virus, Bat herpesvirus, Bat sapovirus, Bear Canon mammarenavirus, Beilong virus, Betacoronavirus, Betapapillomavirus 1-6, Bhanja virus, Bokeloh bat lyssavirus, Borna disease virus, Bourbon virus, Bovine hepacivirus, Bovine parainfluenza virus 3, Bovine respiratory syncytial virus, Brazoran virus, Bunyamwera virus, Caliciviridae virus. California encephalitis virus, Candiru virus, Canine distemper virus, Canine pneumovirus, Cedar virus, Cell fusing agent virus, Cetacean morbillivirus, Chandipura virus, Chaoyang virus, Chapare mammarenavirus, Chikungunya virus, Colobus monkey papillomavirus, Colorado tick fever virus, Cowpox virus, Crimean-Congo hemorrhagic fever virus, Culex flavivirus, Cupixi mammarenavirus, Dengue virus, Dobrava-Belgrade virus, Donggang virus, Dugbe virus, Duvenhage virus, Eastern equine encephalitis virus, Entebbe bat virus, Enterovirus A-D, European bat lyssavirus 1-2, Eyach virus, Feline morbillivirus, Fer-de-Lance paramyxovirus, Fitzroy River virus, Flaviviridae virus, Flexal mammarenavirus, GB virus C, Gairo virus, Gemycircularvirus, Goose paramyxovirus SF02, Great Island virus, Guanarito mammarenavirus, Hantaan virus, Hantavirus Z10, Heartland virus, Hendra virus, Hepatitis A/B/C/E, Hepatitis delta virus, Human bocavirus, Human coronavirus, Human endogenous retrovirus K, Human enteric coronavirus, Human genital-associated circular DNA virus-1, Human herpesvirus 1-8, Human immunodeficiency virus 1/2, Human mastadenovirus A-G, Human papillomavirus, Human parainfluenza virus 1-4, Human paraechovirus, Human picornavirus, Human smacovirus, Ikoma lyssavirus, Ilheus virus, Influenza A-C, Ippy mammarenavirus, Irkut virus, J-virus, JC polyomavirus, Japanese encephalitis virus, Junin mammarenavirus, KI polyomavirus, Kadipiro virus, Kamiti River virus, Kedougou virus, Khuj and virus, Kokobera virus, Kyasanur forest disease virus, Lagos bat virus, Langat virus, Lassa mammarenavirus, Latino mammarenavirus, Leopards Hill virus, Liao ning virus, Ljungan virus, Lloviu virus, Louping ill virus, Lujo mammarenavirus, Luna mammarenavirus, Lunk virus, Lymphocytic choriomeningitis mammarenavirus, Lyssavirus Ozernoe, MS512\.225 virus, Machupo mammarenavirus, Mamastrovirus 1, Manzanilla virus, Mapuera virus, Marburg virus, Mayaro virus, Measles virus, Menangle virus, Mercadeo virus, Merkel cell polyomavirus, Middle East respiratory syndrome coronavirus, Mobala mammarenavirus, Modoc virus, Moijang virus, Mokolo virus, Monkeypox virus, Montana myotis leukoenchalitis virus, Mopeia lassa virus reassortant 29, Mopeia mammarenavirus, Morogoro virus, Mossman virus, Mumps virus, Murine pneumonia virus, Murray Valley encephalitis virus, Nariva virus, Newcastle disease virus, Nipah virus, Norwalk virus, Norway rat hepacivirus, Ntaya virus, O'nyong-nyong virus, Oliveros mammarenavirus, Omsk hemorrhagic fever virus, Oropouche virus, Parainfluenza virus 5, Parana mammarenavirus, Parramatta River virus, Peste-des-petits-ruminants virus, Pichande mammarenavirus, Picornaviridae virus, Pirital mammarenavirus, Piscihepevirus A, Porcine parainfluenza virus 1, porcine rubulavirus, Powassan virus, Primate T-lymphotropic virus 1-2, Primate erythroparvovirus 1, Punta Toro virus, Puumala virus, Quang Binh virus, Rabies virus, Razdan virus, Reptile bornavirus 1, Rhinovirus A-B, Rift Valley fever virus, Rinderpest virus, Rio Bravo virus, Rodent Torque Teno virus, Rodent hepacivirus, Ross River virus, Rotavirus A-I, Royal Farm virus, Rubella virus, Sabia mammarenavirus, Salem virus, Sandfly fever Naples virus, Sandfly fever Sicilian virus, Sapporo virus, Sathuperi virus, Seal anellovirus, Semliki Forest virus, Sendai virus, Seoul virus, Sepik virus, Severe acute respiratory syndrome-related coronavirus, Severe fever with thrombocytopenia syndrome virus, Shamonda virus, Shimoni bat virus, Shuni virus, Simbu virus, Simian torque teno virus, Simian virus 40-41, Sin Nombre virus, Sindbis virus, Small anellovirus, Sosuga virus, Spanish goat encephalitis virus, Spondweni virus, St. Louis encephalitis virus, Sunshine virus, TTV-like mini virus, Tacaribe mammarenavirus, Taila virus, Tamana bat virus, Tamiami mammarenavirus, Tembusu virus, Thogoto virus, Thottapalayam virus, Tick-borne encephalitis virus, Tioman virus, Togaviridae virus, Torque teno canis virus, Torque teno douroucouli virus, Torque teno felis virus, Torque teno midi virus, Torque teno sus virus, Torque teno tamarin virus, Torque teno virus, Torque teno zalophus virus, Tuhoko virus, Tula virus, Tupaia paramyxovirus, Usutu virus, Uukuniemi virus, Vaccinia virus, Variola virus, Venezuelan equine encephalitis virus, Vesicular stomatitis Indiana virus, WU Polyomavirus, Wesselsbron virus, West Caucasian bat virus, West Nile virus, Western equine encephalitis virus, Whitewater Arroyo mammarenavirus, Yellow fever virus, Yokose virus, Yug Bogdanovac virus, Zaire ebolavirus, Zika virus, or Zygosaccharomyces bailii virus Z viral sequence. Examples of RNA viruses that may be detected include one or more of (or any combination of) Coronaviridae virus, a Picornaviridae virus, a Caliciviridae virus, a Flaviviridae virus, a Togaviridae virus, a Bornaviridae, a Filoviridae, a Paramyxoviridae, a Pneumoviridae, a Rhabdoviridae, an Arenaviridae, a Bunyaviridae, an Orthomyxoviridae, or a Deltavirus. In certain example embodiments, the virus is Coronavirus, SARS, Poliovirus, Rhinovirus, Hepatitis A, Norwalk virus, Yellow fever virus, West Nile virus, Hepatitis C virus, Dengue fever virus, Zika virus, Rubella virus, Ross River virus, Sindbis virus, Chikungunya virus, Borna disease virus, Ebola virus, Marburg virus, Measles virus, Mumps virus, Nipah virus, Hendra virus, Newcastle disease virus, Human respiratory syncytial virus, Rabies virus, Lassa virus, Hantavirus, Crimean-Congo hemorrhagic fever virus, Influenza, or Hepatitis D virus.

In certain example embodiments, the virus may be a plant virus selected from the group comprising Tobacco mosaic virus (TMV), Tomato spotted wilt virus (TSWV), Cucumber mosaic virus (CMV), Potato virus Y (PVY), the RT virus Cauliflower mosaic virus (CaMV), Plum pox virus (PPV), Brome mosaic virus (BMV), Potato virus X (PVX), Citrus tristeza virus (CTV), Barley yellow dwarf virus (BYDV), Potato leafroll virus (PLRV), Tomato bushy stunt virus (TBSV), rice tungro spherical virus (RTSV), rice yellow mottle virus (RYMV), rice hoj a blanca virus (RHBV), maize rayado fino virus (MRFV), maize dwarf mosaic virus (MDMV), sugarcane mosaic virus (SCMV), Sweet potato feathery mottle virus (SPFMV), sweet potato sunken vein closterovirus (SPSVV), Grapevine fanleaf virus (GFLV), Grapevine virus A (GVA), Grapevine virus B (GVB), Grapevine fleck virus (GFkV), Grapevine leafroll-associated virus-1, -2, and -3, (GLRaV-1, -2, and -3), Arabis mosaic virus (ArMV), or Rupestris stem pitting-associated virus (RSPaV). In a preferred embodiment, the target RNA molecule is part of said pathogen or transcribed from a DNA molecule of said pathogen. For example, the target sequence may be comprised in the genome of an RNA virus. It is further preferred that CRISPR effector protein hydrolyzes said target RNA molecule of said pathogen in said plant if said pathogen infects or has infected said plant. It is thus preferred that the CRISPR system is capable of cleaving the target RNA molecule from the plant pathogen both when the CRISPR system (or parts needed for its completion) is applied therapeutically, i.e. after infection has occurred or prophylactically, i.e. before infection has occurred.

In certain example embodiments, the virus may be a retrovirus. Example retroviruses that may be detected using the embodiments disclosed herein include one or more of or any combination of viruses of the Genus Alpharetrovirus, Betaretrovirus, Gammaretrovirus, Deltaretrovirus, Epsilonretrovirus, Lentivirus, Spumavirus, or the Family Metaviridae, Pseudoviridae, and Retroviridae (including HIV), Hepadnaviridae (including Hepatitis B virus), and Caulimoviridae (including Cauliflower mosaic virus).

In certain example embodiments, the virus is a DNA virus. Example DNA viruses that may be detected using the embodiments disclosed herein include one or more of (or any combination of) viruses from the Family Myoviridae, Podoviridae, Siphoviridae, Alloherpesviridae, Herpesviridae (including human herpes virus, and Varicella Zorter virus), Malocoherpesviridae, Lipothrixviridae, Rudiviridae, Adenoviridae, Ampullaviridae, Ascoviridae, Asfarviridae (including African swine fever virus), Baculoviridae, Cicaudaviridae, Clavaviridae, Corticoviridae, Fuselloviridae, Globuloviridae, Guttaviridae, Hytrosaviridae, Iridoviridae, Maseilleviridae, Mimiviridae, Nudiviridae, Nimaviridae, Pandoraviridae, Papillomaviridae, Phycodnaviridae, Plasmaviridae, Polydnaviruses, Polyomaviridae (including Simian virus 40, JC virus, BK virus), Poxviridae (including Cowpox and smallpox), Sphaerolipoviridae, Tectiviridae, Turriviridae, Dinodnavirus, Salterprovirus, Rhizidovirus, among others. In some embodiments, a method of diagnosing a species-specific bacterial infection in a subject suspected of having a bacterial infection is described as obtaining a sample comprising bacterial ribosomal ribonucleic acid from the subject; contacting the sample with one or more of the probes described, and detecting hybridization between the bacterial ribosomal ribonucleic acid sequence present in the sample and the probe, wherein the detection of hybridization indicates that the subject is infected with Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Acinetobacter baumannii, Candida albicans, Enterobacter cloacae, Enterococcus faecalis, Enterococcus faecium, Proteus mirabilis, Staphylococcus agalactiae, or Staphylococcus maltophilia or a combination thereof.

Coronavirus

Systems and methods of the presently disclosed invention are designed to detect coronavirus, in an aspect, the target sequence is the 2019-nCoV, also referred to herein as SARS-CoV-2, which causes COVID-19. The coronavirus is a positive-sense single stranded RNA family of viruses, infecting a variety of animals and humans. SARS-CoV is one type of coronavirus infection, as well as MERS-CoV. Detection of one or more coronaviruses are envisioned, including the SARS-CoV-2 detected in Wuhan City. Sequences of the sARS-CoV-2 are available at GISAID accession no. EPI_ISL_402124 and EPI_ISL_402127-402130, and described in DOI: 10.1101/2020.01.22.914952. Further deposits of the SARS-CoV2 are deposited in the GISAID platform include EP_ISL_402119-402121 and EP_ISL_402123-402124; see also GenBank Accession No. MN908947.3. In an aspect, one may use known SARS and SARS-related coronaviruses or other viruses from one or more hosts to generate a non-redundant alignment. Related viruses can be found, for example in bats.

In certain embodiments, the systems are designed to comprise at least one highly active guide polynucleotide which is designed according to the methods disclosed herein. In a preferred embodiment, the guide polynucleotide binds to at least one target sequence that is a unique coronavirus genomic sequence, thereby identifying the presence of coronavirus to the exclusion of other viruses. The systems and methods can be designed to detect a plurality of respiratory infections or viral infections, including coronavirus.

In an aspect the at least one guide polynucleotide binds to a coronavirus sequence encoding a polypeptide that is immunostimulatory to a host immune system. Immunostiumulatory polypeptides have the ability to enhance, stimulate, or increase response of the immune system, typically by inducing the activation or activity of a components of the immune system (e.g. an immune cell). In embodiments, the immunostimulatory polypeptide contributes to immune-mediated disease in the host. In an aspect, the host is a mammal, for example, a human, a bat, or a pangolin, that may be infected by a coronavirus. Cyranoski, D. Did pangolins spread the China coronavirus to people? Nature, 7 Feb. 2020. In certain embodiments, the guide polynucleotide can be designed to detect SARS-CoV-2 or a variant thereof in meat, live anmials and humans so that testing can be performed, for example at markets and other public places where sources of contamination can arise.

Gene targets may comprise ORF lab, N protein, RNA-dependent RNA polymerase (RdRP), E protein, ORF1b-nsp14, Spike glycoprotein (S), or pancorona targets. Molecular assays have been under development and can be used as a starting point to develop guide molecules for the methods and systems described herein. See, “Diagnostic detection of 2019-nCoV by real-time RT-PCR” Charitê, Berlin Germany (17 Jan. 2020)’ Detection of 2019 novel coronavirus (2019-nCoV) in suspected human cases by RT-PCR— Hong Kong University (23 Jan. 2020); PCR and sequencing protocol for 2019-nCoV—Department of Medical Sciences, Ministry of Public Health, Thailand (updated 28 Jan. 2020); PCR and sequencing protocols for 2019-nCoV-National Institute of Infectious Diseases Japan (24 Jan. 2020); US CDC panel primer and probes— U.S. CDC, USAV— U.S. CDC, USA (28 Jan. 2020); China CDC Primers and probes for detection 2019-nCoV (24 Jan. 2020), incorporated in their entirety by reference. Further, the guide molecule design may exploit differences or similarities with SARS-CoV. Researchers have recently identified simialrities and fifrferences between 2019-nCoV and SARS-CoV. “Coronavirus Genome Annotation Reveals Amino Acid Differences with Other SARS Viruses,” genomeweb, Feb. 10, 2020. For example, guide molecules based on the 8a protein, which was present in SARS-CoV but absent in SARS-CoV-2, can be utilized to differentiate between the viruses. Similarly, the 8b and 3b proteins have different lengths in SARS-CoV and sARS-CoV-2 and can be utilized to design guide molecules to detect non-overlapping proteins of nucleotides encoding in the two viruses. Wu et al., Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China, Cell Host & Microbe (2020), DOI: 10.1016/j.chom.2020.02.001, incorporated herein by reference, including all supplemental information, in particular Table 51. Mutations may also be detected, with guide and/or primers designed specifically to detect, for example, changes in the SARS-CoV-2 virus. In an embodiment, the guide or primer can be designed to detect the D614G mutation in the SARS-CoV-2 spike protein. See, Korber et al., Cell 182, 812-827 (2020); doi: 10.1016/j.cell.2020.06.043. Other mutations in the spike protein can be designed utilizing the COVID-19 viral genome analysis pipeline available at cov.lanl.gov. Further resources to design primers and guides to detect coronavirus or coronavirus mutations can be found at Starr, et al., “Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints in Folding and ACE2 Binding,” Cell, 182, 1-16 (2020); doi: 10.1016/j.cell.2020.08.012.

In an aspect, the systems and methods of detection can be used to identify and/or distinguish SARS-CoV-2 variants. Exemplary variants include a variant identified in the United Kingdom, referred to as 201/501Y.V1, VOC 202012/01, or B.1.1.7. Similarly, a variant identified in South Africa known as 20H/501Y.V2 or B.1.351. Another exemplary variant identified in Brazil, known as P.1, may be detected by the systems and methods described herein. In an aspect, the variants can be identified based on unique mutations associated therewith. In an exemplary embodiment, sequences with at least one, two, three, four or more SNPs of the sequences can be identified. In an aspect, mutations or deletions associated with a particular SARS-CoV-2 lineage can be identified. See, e.g. virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563, identifying non-synonymous mutations and deletions inferred to occur in B1.1.7 lineage. In an aspect, the mutation is in the ORF lab, spike, Orf8, or N gene.

The systems and methods of detection can be used to identify single nucleotide variants, detection based on rRNA sequences, screening for drug resistance, monitoring microbe outbreaks, genetic perturbations, and screening of environmental samples, as described in PCT/US2018/054472 filed Oct. 22, 2018, at [0183]-[0327], incorporated herein by reference.

In certain example embodiments, the systems, devices, and methods disclosed herein may be used for biomarker detection. For example, the systems, devices and method disclosed herein may be used for SNP detection and/or genotyping. The systems, devices and methods disclosed herein may be also used for the detection of any disease state or disorder characterized by aberrant gene expression. Aberrant gene expression includes aberration in the gene expressed, location of expression and level of expression. Multiple transcripts or protein markers related to cardiovascular, immune disorders, and cancer among other diseases may be detected. In certain example embodiments, the embodiments disclosed herein may be used for cell free DNA detection of diseases that involve lysis. In certain example embodiments, the embodiments could be utilized for faster and more portable detection for pre-natal testing of cell-free DNA. The embodiments disclosed herein may be used for screening panels of different SNPs associated with, among others, different coronaviruses, evolving SARS-CoV2, and other related respiratory viral infections. As described herein elsewhere, closely related genotypes/alleles or biomarkers (e.g. having only a single nucleotide difference in a given target sequence) may be distinguished by introduction of a synthetic mismatch in the gRNA.

In an aspect, the invention relates to a method for detecting target nucleic acids in samples, comprising:

distributing a sample or set of samples into one or more individual discrete volumes, the individual discrete volumes comprising a CRISPR system according to the invention as described herein;

incubating the sample or set of samples under conditions sufficient to allow binding of the one or more guide RNAs to one or more target molecules;

activating the CRISPR effector protein via binding of the one or more guide RNAs to the one or more target molecules, wherein activating the CRISPR effector protein results in modification of the RNA-based masking construct such that a detectable positive signal is generated; and

detecting the detectable positive signal, wherein detection of the detectable positive signal indicates a presence of one or more target molecules in the sample.

The sensitivity of the assays described herein are well suited for detection of target nucleic acids in a wide variety of biological sample types, including sample types in which the target nucleic acid is dilute or for which sample material is limited. Methods for field deployable and rapid diagnostic assays can be optimized for the type of sample material utilized. See, e.g. Myhrvold et al., 2018. Biomarker screening may be carried out on a number of sample types including, but not limited to, saliva, urine, blood, feces, sputum, and cerebrospinal fluid. The embodiments disclosed herein may also be used to detect up- and/or down-regulation of genes. For example, a sample may be serially diluted such that only over-expressed genes remain above the detection limit threshold of the assay.

In certain embodiments, the present invention provides steps of obtaining a sample of biological fluid (e.g., urine, blood plasma or serum, sputum, cerebral spinal fluid), and extracting the DNA or RNA. The mutant nucleotide sequence to be detected, may be a fraction of a larger molecule or can be present initially as a discrete molecule.

In certain embodiments, DNA is isolated from plasma/serum of a cancer patient. For comparison, DNA samples isolated from neoplastic tissue and a second sample may be isolated from non-neoplastic tissue from the same patient (control), for example, lymphocytes. The non-neoplastic tissue can be of the same type as the neoplastic tissue or from a different organ source. In certain embodiments, blood samples are collected and plasma immediately separated from the blood cells by centrifugation. Serum may be filtered and stored frozen until DNA/RNA extraction.

In an aspect, sample preparation can comprise methods as disclosed herein to circumvent other RNA extraction methods and can be used with standard amplification techniques such as RT-PCR as well as the CRISPR-Cas detection methods disclosed herein. In an aspect, the method may comprise a one-step extraction-free RNA preparation method that can be used with samples tested for coronavirus, which may be, in an aspect, a RT-qPCR testing method, a lateral flow detection method or other CRISPR-Cas detection method disclosed herein. Advantageously, the RNA extraction method can be utilized directly with other testing protocols. In an aspect, the method comprises use of a nasopharyngeal swab, nasal saline lavage, or other nasal sample (e.g., anterior nasal swab) with Quick Extract™ DNA Extraction Solution (QE09050), Lucigen, or QuickExtract Plant DNA Extraction Solution, Lucigen. In an embodiment, the solution allows for isolation of polynucleotides without the requirement of further extraction prior to further processing. In an aspect, the sample is diluted 2:1, 1:1 or 1:2 sample:DNA extraction solution. The sample:extraction mix is incubated at about 90° C. to about 98° C., preferably about 95° C. In another aspect, incubation is performed at between about 20° C. to about 90° C., about 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89 or 90° C. The incubation period can be about 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30 minutes, preferably about 4 to 6 minutes, or about 5 minutes. Incubation time and temperature may vary depending on sample size and quality, and incubation time may increase if using lower temperature. Current CDC Real-Time RT-PCR Diagnostic Panel are as described at fda.gov/media/134922/download, “CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel.” In certain embodiments, the DNA extraction solution can remain with the sample subsequent to incubation and be utilized in the next steps fo detection methods. In an aspect, the detection method is an RT-qPCR reaction and the extraction solution is kept at a concentration of less than 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3% of the reaction mixture, where the reaction mixture comprises the detection reaction reagents, sample and extraction solution.

In certain embodiments, a bead is utilized with particular embodiments of the invention and may be included with the extraction solution. The bead may be used to capture, concentrate or otherwise enrich for particular material. The bead may be magnetic, and may be provided to capture nucleic acid material. In another aspect, the bead is a silica bead. Beads may be utilized in an extraction step of the methods disclosed herein. Beads can be optionally used with the methods described herein, including with the one-pot methods that allow for concentration of viral nucleic acids from large volume samples, such as saliva or swab samples to allow for a single one-pot reaction method. Concentration of desired target molecules can be increased by about 10-fold, 50-fold, 100-fold, 200-fold, 500-fold, 800-fold, 1000-fold, 1500-fold, 2000-fold, 2500-fold, 3000-fold, or more.

Magnetic beads in a PEG and salt solution are preferred in an aspect, and in embodiments bind to viral RNA and/or DNA which allows for concentration and lysis concurrently. Silica beads can be used in another aspect. Capture moieties such as oligonucleotide functionalized beads are envisioned for use. The beads may be using with the extraction reagents, allowed to incubate with a sample and the lysis/extraction buffer, thereby concentrating target molecules on the beads. Extraction can be performed as described elsewhere herein, at 22° C.-60° C., with subsequent isothermal amplification and/or CRISPR detection performed under conditions as described elsewhere herein. When used with a cartridge device detailed elsewhere herein, a magnet can be activated and the beads collected, with optional flushing of the extraction buffer and one or more washes performed. Advantageously, the beads can be used in the one-pot methods and systems without additional washings of the beads, allowing for a more efficient process without increased risks of contamination in multi-step processes. Beads can be utilized with the isothermal amplifications detailed herein, and the beads can flow into an amplification chamber of the cartridge or be maintained in the pot for the amplification step. Upon heating, nucleic acid can be released off the beads.

In certain example embodiments, target nucleic acids are detected directly from a crude or unprocessed sample, such as blood, serum, saliva, cebrospinal fluid, sputum, or urine. In certain example embodiments, the target nucleic acid is cell free DNA.

EXAMPLES Example 1— Coronavirus Assay Development

Systems and methods can be designed for the detection and diagnosis of viruses and viral infections, including Covid-2019, optionally with acute respiratory infections using the disclosure detailed herein. The systems can comprise two or more CRISPR Cas systems to multiplex, for example, detection of Covid-2019, and other coronaviruses such as SARS-CoV and MERS-CoV. Sequences of the 2019-nCoV are available at GISAID accession no. EPI_ISL_402124 and EPI_ISL_402127-402130, and described in DOI: 10.1101/2020.01.22.914952. Further deposits of the Wuhan coronavirus deposited in the GISAID platform include EP_ISL_402119-402121 and EP_ISL_402123-402124; see also GenBank Accession No. MN908947, and guide design can be predicated on genome sequences disclosed therein and in Tian et al, “Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody”; doi: 10.1101/2020.01.28.923011, incorporated by reference, which details human monoclonal antibody, CR3022 binding of the 2019-nCoV RBD (KD of 6.3 nM). Guide design can target unique viral genomic regions of the 2019-nCoV or conserved genomic regions across one or more viruses of the coronavirus family. Gene targets may comprise ORF lab, N protein, RNA-dependent RNA polymerase (RdRP), E protein, ORF1b-nsp14, Spike glycoprotein (S), or pancorona targets, including guide molecules based on the 8a protein, which was present in SARS-CoV but absent in 2019-nCoV, utilized to differentiate between the viruses. Similarly, the 8b and 3b proteins have different lengths in SARS-CoV and 2019-nCoV and can be utilized to design guide molecules to detect non-overlapping proteins of nucleotides encoding in the two viruses. Wu et al., Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China, Cell Host & Microbe (2020), DOI: 10.1016/j.chom.2020.02.001, incorporated herein by reference, including all supplemental information, in particular Table 51. Molecular assays have been under development and can be used as a starting point to develop guide molecules for the methods and systems described herein.

Detection of respiratory viruses such as coronavirus may include a thermostable CRISPR-Cas protein as described herein, which may be a Cas13a ortholog. As described elsewhere herein, one or more Cas13a orthologs may be utilized in a multiplex design, including the thermostable Cas13a orthologs described herein, where such thermostability confers further rapidity to the diagnostic and detections platforms and methods disclosed herein.

Coronavirus detection can comprise two or more detection systems utilizing RNA targeting Cas effector proteins; DNA targeting Cas effector proteins, or a combination thereof. The RNA-targeting effector proteins may be a Cas13 protein, such as Cas13a, Cas13b, or Cas13c, including one of the thermostable Cas13a proteins described herein. The DNA-targeting effector protein may be a Type V protein, e.g. Cas12 protein such as Cpf1 and C2c1. Multiplexing systems can be designed such that different Cas proteins with different sequence specificities or other motif cutting preferences can be used, including, in certain embodiments, at least one Cas13a thermostable protein described herein. See International Publication WO 2019/126577. Type VI and Type V Cas proteins are known to possess different cutting motif preferences. See Gootenberg et al. “Multiplexed and portable nucleic acid detection platform with Cas13b, Cas12a, and Csm6.” Science. Apr. 27, 2018, 360:439-444; International Publication WO 2019/051318. Thus, embodiments disclosed herein may further comprise multiplex embodiments comprising two or more Type VI Cas proteins with different cutting preferences, or one or more Type VI Cas proteins and one or more Type V case proteins.

In certain example embodiments, the coronavirus assay comprises a Type VI Cas protein disclosed herein and guide molecule comprising a guide sequence configured to direct binding of the CRISPR-Cas complex to a target molecule and a labeled detection molecule (“RNA-based masking construct”). A multiplex embodiment can be designed to track one or more variants of coronavirus or one or more variants of coronavirus, including the 2019-nCoV, in combination with other viruses, for example, Human respiratory syncytial virus, Middle East respiratory syndrome (MERS) coronavirus, Severe acute respiratory syndrome-related (SARS) coronavirus, and influenza.

In certain embodiments, the detection assay can be provided on a lateral flow device, as described herein. The lateral flow device may comprise a flexible substrate, such as a paper substrate or a flexible polymer-based substrate, which can include freeze-dried reagents for detection assays with a visual readout of the assay results. See, WO 2019/071051 at [0145]-[0151] and Example 2, specifically incorporated herein by reference. Accordingly, the assay can be adapted for field diagnostics, including use of visual readout on a lateral flow device, rapid, sensitive detection and can be deployed for early and direct detection.

Example 2— Lateral Flow Cornavirus Detection

Detection of coronavirus targets was performed using RPA amplification for 25 minutes followed by a 30 minute Cas 13 reaction using the following primers and guides:

TABLE 3 S gene GAAATTAATACGACTCACTATAGGGAGGTT RPA TCAAACTTTACTTGCTTTACATAGA Forward (SEQ ID NO: 62016) S gene TCCTAGGTTGAAGATAACCCACATAATAAG  RPA (SEQ ID NO: 62017) Reverse Sgene GAUUUAGACUACCCCAAAAACGAAGGGGAC LwCas13a UAAAACGCAGCACCAGCUGUCCAACCUGAA crRNA GAAG (SEQ ID NO: 62018) Orflab GAAATTAATACGACTCACTATAGGGCGAAG RPA TTGTAGGAGACATTATACTTAAACC Forward (SEQ ID NO: 62019) Orflab TAGTAAGACTAGAATTGTCTACATAAGCAGC RPA (SEQ ID NO: 62020) Reverse Orflab GAUUUAGACUACCCCAAAAACGAAGGGGACU LwCas13a AAAACCCAACCUCUUCUGUAAUUUUUAAACU crRNA AU (SEQ ID NO: 62021)

Results are provided in FIG. 1 , with S gene detection shown on the left and Orflab on the right, and FIG. 2B. The assay has been further validated by fluorescence in FIG. 2A.

Example 3. RNA Preparation for COVID-19 Detection

One of the major bottlenecks for COVID-19 diagnosis is the limited availability of RNA extraction kits for preparing virus RNA from patient samples and the low-throughput nature of the extraction procedure. Here, Applicants describe a one-step extraction-free RNA preparation method that can be carried out in 5 minutes and the reaction can be used directly with the CDC COVID-19 RT-qPCR testing protocol, thus increasing throughput, and alleviating supply chain issues.

Materials and Reagents

Quick Extract™ DNA Extraction Solution (QE09050), Lucigen

Protocol

Step 1. Dilute nasopharyngeal swab stored in Viral Transport Medium or Human Specimen Control (HSC) 1:1 with Quick Extract™ DNA Extraction Solution. For example, in a fresh PCR tube, mix 20 ul of swab sample with 20 ul of Quick Extract.

Step 2. Incubate swab-Quick Extract mix at 95° C. for 5 minutes. Allow reaction to cool on ice before proceeding.

Step 3. Use reaction from step (2) for qRT-PCR. Make sure the amount from step (2) does not exceed 10% of the total qRT-PCR reaction volume. For example, if a RT-qPCR reaction has a total volume of 50 ul, do not use more than 5 ul of the reaction mix from step (2).

Assay Development and Preliminary Validation

Applicants evaluated a number of buffer compositions to identify one that achieved efficient lysis of enveloped virus while preserving the activity of the CDC recommended RT-qPCR reaction (TaqPath™ 1-Step RT-qPCR Master Mix). Of all of the buffers tested, Quick Extract™ DNA Extraction Solution provided satisfactory results.

To confirm that the presence of QE does not interfere with RT-qPCR activity, comparison of RT-qPCR reactions using synthetic SARS-CoV-2 gene fragment (Twist Synthetic SARS-CoV-2 RNA Control 1, SKU:102019) dissolved in either ddH₂O or in a 50:50 ddH₂O:Quick Extract mixture was performed. Each RT-qPCR reaction was set up with a total volume of 10 ul (1 ul of RNA sample, 0.5 ul of CDC probe N1, 2.5 ul of TaqPath RT-qPCR master mix, and 6 ul of ddH₂O). From these reactions, Applicants found that Quick Extract at a final concentration of 5% did not negatively affect the RT-qPCR reaction (FIG. 1A).

Preliminary validation of the Quick Extract RNA preparation procedure was conducted on coronavirus positive nasopharyngeal swabs where it was found that RNA samples prepared using Quick Extract supported similarly sensitive detection of coronavirus as QIAmp Viral RNA Miniprep for all 4 swab samples (FIG. 1B). To simulate low viral load, coronavirus positive swabs were diluted 1:10 in pooled nasopharyngeal swabs from 5 unique, healthy donors (Lee Biosolutions, SKU:991-31-NC-5) prior to purification or Quick Extract treatment. For the QIAmp Viral RNA Miniprep conditions, 100 ul of diluted swab sample was used for extraction and was eluted using 100 ul of ddH₂O. 1 ul of the elution was used in a 10 ul RT-qPCR reaction. For the Quick Extract conditions, 1 ul of Quick Extract preparation was used for each 10 ul RT-qPCR reaction.

Example 4. Development of a One Pot RT-LAMP Cas12b SHERLOCK Reaction

Applicants developed a research protocol for a SHERLOCK-based COVID-19 coronavirus detection. The basic protocol is outlined in FIG. 16 . A nasopharyngeal swab or saliva sample is collected from a patient. The sample is added to a tube containing SHERLOCK reagents. The tube is heated for 60 minutes at 60° C. A SHERLOCK detection lateral flow strip is then dipped into the reaction in the tube and the strip is then analyzed for results. Table 4 shows final reaction parameters for reagents in the tube.

The lateral flow strip is inserted directly into this reaction as shown in FIG. 16 .

TABLE 4 Final Reaction Parameters Initial Final Amount Concentration Concentration (μL) Isothermal 10X 1X 5 amplification buffer dNTPs 10 mM 1.4 mM 7 MgSO4 100 mM 8 mM 4 Bst 2.0 8000 units/mL 320 units/mL 2 WS RTx 15,000 units/mL 300 units/mL 1 Aap Cas12b 2 mg/mL or 500 nM 1.625 15.4 μM Aac Cas12b 360 ng/μL or 500 nM 2.5 crRNA 10 μM WCV332 100 μM 125 nM 0.0625 Taurine 500 mM 50 nM 5 LAMP primer pool 10X 1X 5 Sample 5 H2O 11.8125 Total 50

The different reaction additives that were used to optimize the assay is shown in FIG. 17 . FIG. 18 shows results obtained for assessing limit of detection by lateral flow assay at 60° C. for 60 minutes. The limit of detection was 100 molecules per reaction.

Results obtained by SHERLOCK assay were compared to results obtained by qRT-PCR, as shown in FIG. 19 . The assay can also be performed using a sous vide cooker, as illustrated in FIG. 20, 41 .

Example 5. Exemplary Use of Device in Diagnostic Methods

One exemplary device that can be utilized at point of care, in home environments, and/or for distribution as a take home device is shown in FIG. 21 . The device can advantageously be disposable and can offer rapid instrument-free visualization of the nucleic acid amplification products of the methods disclosed herein. In an exemplary embodiment, the disposable device is compatible with nucleic acid amplification technologies, including LAMP. The device comprises an ampule which can contain the lateral flow buffer for the lateral flow readout of the amplification result. A sample can be loaded into a container which may comprise the reagents for the SHERLOCK reaction, including amplification reagents and CRISPR-Cas protein and guide molecules, which may optionally be stored in the container as lyophilized reagents. (See FIG. 21 at step 1). The device can further comprise a container for the contents of the SHERLOCK reaction, including LAMP amplification reagents and CRISPR-Cas protein and guide molecules. The device can also be configured to comprise the lateral flow strip, such that after the reaction is conducted, a lateral flow readout is provided in the device utilizing an instrument-free method for the visualization of the reaction products without cross-contamination.

Example 6. Point-of-Care Testing for COVID-19 Using SHERLOCK Diagnostics

Rapid point-of-care (POC) tests capable of being run in any low-resource setting, including at home, are needed to adequately combat the COVID-19 pandemic and re-open society. Applicants previously described a protocol for using the CRISPR-based SHERLOCK (Specific High Sensitivity Enzymatic Reporter UnLOCKing) technique (Gootenberg et al., 2017, 2018) for the detection of SARS-CoV-2. SHERLOCK achieves sensitive detection of SARS-CoV-2 through two consecutive reactions: (1) amplification of the virus RNA using an isothermal amplification reaction, and (2) detection of the resulting amplicon using CRISPR-mediated collateral reporter unlocking. Additional CRISPR-based tests have also been recently developed (Broughton et al., 2020; Ding et al., 2020; Guo et al., 2020; Lucia et al., 2020), but these all rely on two separate reaction steps, which requires liquid handling and opening of tubes. These steps add complexity and can lead to contamination, prohibiting their use outside laboratory environments and precluding use by lay individuals. Other POC tests for COVID-19 have been authorized by the U.S. Food and Drug Administration (FDA), including the Abbott ID NOW and Cepheid Genexpert, but these require complex and expensive instrumentation, limiting use to complex labs and hospitals by trained professionals. Some isothermal pre-amplification methods, such as Loop-mediated Isothermal Amplification (LAMP), have been developed as POC tests (Zhang et al., 2020), but these rely on amplification that can be nonspecific.

Currently, the only tests readily available for at-home or low-resource settings are serology paper-based tests (Whitman et al., 2020). However, these are not adequate for diagnosing live infection as antibodies take 1-2 weeks to become detectable in blood and only signify previous exposure. Therefore, Applicants sought to create a POC COVID-19 nucleic acid test that can be run in any setting. Through a series of optimizations, Applicants developed a streamlined, 1-hour SHERLOCK based test that requires no sample extraction and can be performed at one temperature in a single reaction with minimal fluid handling and visual colorimetric readout (FIG. 16 ).

The one-pot SHERLOCK SARS-CoV-2 detection protocol works in the following three steps, without requiring separate virus RNA extraction:

Step (1) 5 mins at 95° C. lysis of virus-containing patient sample using QuickExtract to release virus RNA; Step (2) l hr at 60° C. detection of virus RNA using one-step SHERLOCK reaction; Step (3) 2 mins at visual read out of the detection room temp result by eye using a commercially-available paper dipstick.

In order to integrate the isothermal amplification step with the CRISPR-mediated detection step, Applicants sought to establish a common reaction condition capable of supporting both steps. Due to the supply chain constraints for the commercially-available recombinase polymerase amplification (RPA) reagents and difficulties in producing a rapid one-pot RPA test for sensitive RNA detection, Applicants chose loop-mediated isothermal amplification (LAMP) reaction for amplifying the virus RNA. The requisite enzymes for LAMP are more readily available from a number of commercial suppliers and the LAMP buffers are simpler and more amenable to systematic optimization with Cas enzymes.

To determine the optimal combination of LAMP primers and guides, Applicants designed 29 sets of LAMP primers targeting different regions of the SARS-CoV-2 genome and identified the best primer set for amplifying gene N (FIG. 25A). As LAMP operates at a higher temperature than RPA (55-65° C. compared to 42° C.), a one-pot reaction demands a Cas enzyme with collateral activity that is thermostable. Of the various Cas proteins Applicants explored, Cas12b from Alicyclobacillus acidiphilus (AapCas12b) (Teng et al., 2018) maintained sufficient activity in the same temperature range as LAMP (FIG. 25B). However, because the AapCas12b locus did not contain a CRISPR array, the published single guide RNA (sgRNA) for AapCas12b used a direct repeat (DR) sequence from Alicyclobacillus macrosporangiidus Cas12b, which could impede activity. To remedy this, Applicants searched for alternative orthologs with similar protein sequences to AapCas12b and found that Alicyclobacillus acidoterrestris Cas12b (AacCas12b) shared a 95% sequence homology (Shmakov et al., 2015). Additionally, the AacCas12b tracrRNA and predicted AapCas12b tracrRNA are 97% identical. Given the high degree of similarity between AapCas12b and AacCas12b protein and tracrRNA, Applicants surmised that the sgRNA for AacCas12b should closely match the cognate AapCas12b DR-tracrRNA hybrid. Indeed, reactions combining AapCas12b enzyme with AacCas12b sgRNA produced more robust and specific nuclease activity compared to the published AapCas12b sgRNA (FIG. 25C).

For the best LAMP amplicon, Applicants tested 18 sgRNAs to identify the optimal combination of primers and guide sequence (FIG. 25D). Using this combination in a one pot reaction, Applicants found that AapCas12b generated faster and higher collateral activity than AacCas12b protein (FIG. 25E). Applicants further optimized one-pot reaction components by screening 94 additives to improve thermal stability, finding that addition of taurine significantly improved reaction kinetics (FIG. 25F).

Applicants profiled the optimized reaction with a lateral flow readout and an RNA extraction-free input using SARS-CoV-2 genome standards spiked into nasopharyngeal (NP) swab to determine limit of detection (LOD), ideal incubation temperature, readout time, and robustness. Applicants found that the LOD of the reaction was 100 copies of SARS-CoV-2 (FIG. 18 ). This LOD was reliable and reproducible over 30 replicates (FIG. 6 ). At twice the LOD, the ideal incubation parameters were 60° C. for at least 50 minutes (FIG. 26A, 26B). The reaction components could be formulated as a mastermix and maintained functionality after 6 freeze-thaw cycles (FIG. 26C). The assay exhibited no cross-reactivity with the SARS or MERS coronavirus genomes (FIG. 26D). The reaction could be performed using either a standard heat block or via a water bath maintained by a commercially-available low-cost (under $40 USD) sous-vide cooker (FIG. 20 ).

Finally, Applicants evaluated the one-pot SHERLOCK detection on 12 positive and 5 negative patient NP swabs. Applicants' assay correctly identified 35/36 positive patient replicates and 15/15 negative patient replicates, resulting in a sensitivity of 97% and specificity of 100% (FIGS. 19 and 27, 42A). To further simplify the assay workflow, Applicants tested whether lysis using QuickExtract at room temperature (22° C.) or the one-pot incubation temperature (60° C.) for 10 mins would be sufficient for detection. As QuickExtract contains Proteinase K that inhibits SHERLOCK without heat inactivation at 95° C., Applicants added Proteinase K Inhibitor to the SHERLOCK reaction. In both cases, Applicants could identify 33/36 positive patient replicates (FIGS. 28A, 28B). Comparison of RT-qPCR Ct values between the lysis methods suggested that both lysis methods are viable alternatives for streamlining the assay workflow, though with a slight decrease (0.2/0.4 Ct at 60° C. and 0.4/0.7 Ct for 22° C. for CDC N1/N2) in sensitivity (FIG. 29 ).

Materials and Methods

Design of LAMP and SHERLOCK reactions. Applicants designed LAMP amplification primers and SHERLOCK AapCas12b guide RNAs to target the N gene of SARS-CoV-2. The N gene is known to be present at higher copy numbers than other segments of the SARS-CoV-2 genome, which helps to increase the detection sensitivity. Below are the LAMP primer sequences and SHERLOCK AapCas12b guide RNAs:

TABLE 5 LAMP Primers and Cas Guide F3: 5'-GCTGCTGAGGCTTCTAAG-3' (SEQ ID NO: 62022) B3: 5'-GCGTCAATATGCTTATTCAGC-3' (SEQ ID NO: 62023) FIP: 5'-GCGGCCAATGTTTGTAATCAG TAGACGTGGTCCAGAACAA-3' (SEQ ID NO: 62024) BIP: 5'-TCAGCGTTCTTCGGAATGTCGC TGTGTAGGTCAACCACG-3' (SEQ ID NO: 62025) Loop 5'-CCTTGTCTGATTAGTTCCTGGT-3' Forward: (SEQ ID NO: 62026) Loop 5'- TGGCATGGAAGTCACACC -3' Reverse: (SEQ ID NO: 62027) AapCas12 5'- b Guide GUCUAGAGGACAGAAUUUUUCAACGG RNA GUGUGCCAAUGGCCACUUUCCAGGUG targeting GCAAAGCCCGUUGAGCUUCUCAAAUC UGAGAAGUGGCAC CGAAGAACGCUG AAGCGCUG -3' (SEQ ID NO: 62028) (The spacer matching N gene is underlined.) SARS- GCAAAGCCCGUUGAGCUUCUCAAAUCU  CoV-2 N GAGAAGUGGCACCGAAGAACGCUGAAG gene: CGCUG (SEQ ID NO: 62029)

AapCas12b Protein Sequence:

(SEQ ID NO: 62030) MAVKSMKVKLRLDNMPEIRAGLWKLHTEVNAGVRYY TEWLSLLRQENLYRRSPNGDGEQECYKTAEECKAE LLERLRARQVENGHCGPAGSDDELLQLARQLYELL VPQAIGAKGDAQQIARKFLSPLADKDAVGGLGIAK AGNKPRWVRMREAGEPGWEEEKAKAEARKSTDRTA DVLRALADFGLKPLMRVYTDSDMSSVQWKPLRKGQ AVRTWDRDMFQQAIERMMSWESWNQRVGEAYAKLV EQKSRFEQKNFVGQEHLVQLVNQLQQDMKEASHGL ESKEQTAHYLTGRALRGSDKVFEKWEKLDPDAPFD LYDTEIKNVQRRNTRRFGSHDLFAKLAEPKYQALW REDASFLTRYAVYNSIVRKLNHAKMFATFTLPDAT AHPIWTRFDKLGGNLHQYTFLFNEFGEGRHAIRFQ KLLTVEDGVAKEVDDVTVPISMSAQLDDLLPRDPH ELVALYFQDYGAEQHLAGEFGGAKIQYRRDQLNHL HARRGARDVYLNLSVRVQSQSEARGERRPPYAAVF RLVGDNHRAFVHFDKLSDYLAEHPDDGKLGSEGLL SGLRVMSVDLGLRTSASISVFRVARKDELKPNSEG RVPFCFPIEGNENLVAVHERSQLLKLPGETESKDL RAIREERQRTLRQLRTQLAYLRLLVRCGSEDVGRR ERSWAKLIEQPMDANQMTPDWREAFEDELQKLKSL YGICGDREWTEAVYESVRRVWRHMGKQVRDWRKDV RSGERPKIRGYQKDVVGGNSIEQIEYLERQYKFLK SWSFFGKVSGQVIRAEKGSRFAITLREHIDHAKED RLKKLADRIIMEALGYVYALDDERGKGKWVAKYPP CQLILLEELSEYQFNNDRPPSENNQLMQWSHRGVF QELLNQAQVHDLLVGTMYAAFSSRFDARTGAPGIR CRRVPARCAREQNPEPFPWWLNKFVAEHKLDGCPL RADDLIPTGEGEFFVSPFSAEEGDFHQIHADLNAA QNLQRRLWSDFDISQIRLRCDWGEVDGEPVLIPRT TGKRTADSYGNKVFYTKTGVTYYERERGKKRRKVF AQEELSEEEAELLVEADEAREKSVVLMRDPSGIIN RGDWTRQKEFWSMVNQRIEGYLVKQIRSRVRLQES ACENTGDI*

Specimen and nucleic acid extraction. Two types of patient samples have been tested for compatibility with one-pot SHERLOCK. All samples should be collected and processed according to the appropriate biosafety procedure.

a. RNA extracted from patient samples: The patient sample should be collected according to the appropriate biosafety procedures. Please reference the 2020 CDC COVID-19 test protocol for details on specimen collection and subsequent nucleic acid extraction. The input for this protocol, beginning with Step (1), can be the same extracted nucleic acid as used in qRT-PCR assays.

b. Nasopharyngeal (NP) swabs: NP swabs dissolved in viral transport media (VTM) or TE can be directly used.

Reagents.

For Step (1)—lysis of viral sample:

-   -   QuickExtract DNA Extraction Solution (QE09050), Lucigen. Once         thawed, aliquot and store at −20° C. to avoid >3 freeze-thaw         cycles.

For Step (2)—one-pot SHERLOCK detection reaction:

-   -   Bst 2.0 WarmStart® DNA Polymerase (M0538L), New England BioLabs     -   WarmStart® RTx Reverse Transcriptase (M0380L), New England         BioLabs     -   10X Isothermal Amplification Buffer (B0374S), New England         BioLabs, supplied with M0538L and M0380L     -   100 mM MgSO4 (B1003S), New England BioLabs, supplied with M0538L         and M0380L     -   10 mM Deoxynucleotide (dNTP) Solution Mix (N0447L), New England         BioLabs     -   Taurine (86329-100G), Millipore Sigma     -   AapCas12b protein purified according to Kellner et al., Nature         Protocols 2019, stored as 10 μL aliquots at 2 mg/mL.     -   Guide RNA for detecting N gene can be ordered from Synthego     -   Reporter DNA for lateral flow read out (Lateral Flow Reporter:         /56-FAM/TTTTTTT/3Bio/), can be ordered from IDT     -   (Optional) Proteinase K Inhibitor (539470-10MG), Millipore         Sigma. Resuspend 10 mg of Proteinase K Inhibitor with 150 μL of         DMSO to make the stock solution. Dilute stock solution 1:100         with ddH2O to make working aliquots. Store both stock and         working solutions at −20° C.     -   10X LAMP Primer Mix:

TABLE 6 LAMP Primer Mix. LAMP Primer (100 μM) Amount (μL) F3 2 B3 2 FIP 16 BIP 16 Loop F 4 Loop B 4 ddH₂O 56 Total 100

A Sherlock mastermix can be prepared as follows:

TABLE 7 Initial Final Amount concentration concentration (uL) Isothermal 10 X 1 X 5 amplification buffer dNTPs  10 mM 1.4 mM 7 MgSO₄ 100 mM   8 mM 4 WS Bst 2.0 8000 units/mL 320 units/mL 2 WS RTx 15,000 300 units/mL 1 units/mL Aap Cas12b 2 mg/mL or 500 nM 1.625 15.4 uM Aac Cas12b 360 ng/uL or 500 nM 2.5 crRNA  10 uM Lateral Flow 100 uM 125 nM 0.0625 Reporter Taurine 500 mM  50 mM 5 LAMP 10 X 1 X 5 primer mix ddH₂O 11.8125 Total 45

If lysing samples at 22° C. or 60° C. instead of 95° C., replace 2 uL of ddH2O with 2 uL of Proteinase K Inhibitor working solution.

For Step (3) reading out using lateral flow dipstick:

-   -   HybriDetect Dipstick (MGHD 1), Milenia Biotec GmbH Positive         control sequences     -   SARS-CoV-2 RNA control (102019), Twist Bioscience

Equipment.

-   -   95° C. heat block or water bath     -   60° C. heat block or water bath     -   Alternative: a sous vide immersion cooker capable of supporting         the temperature range of 55° C. to 95° C. can also be used         (example).

One-Step SHERLOCK Protocol for SARS-CoV-2 Detection

***IMPORTANT NOTE: To prevent sample contamination from confounding detection result, two different work areas should be used for performing Steps (1)/(2) and (3). Steps (1)/(2) should be performed in a pre-amplification area and is especially sensitive to contamination. Amplified samples should not be opened in the work area for Steps (1)/(2). A separate area for post-amplification reactions should be used for performing Step (3) of the protocol. After incubation, reactions from Step (2) should be thoroughly spun down after incubation before opening in the post-amplification area to carry out Step (3).

Step (1)— Lysis of patients sample. *PERFORMED IN THE PRE-AMPLIFICATION AREA*

NP swab sample should be lysed using the QuickExtract lysis buffer.

Mix 10 μL of NP swab sample with 10 μL of Quick Extract in an eppendorf tube.

Incubate the sample-QuickExtract mixture at 95° C. for 5 minutes (or at room temperature or 60° C. for 10 mins) and proceed to Step (2).

Step (2)— One pot SHERLOCK detection. *PERFORMED IN THE PRE-AMPLIFICATION AREA*

For each sample, set up one reaction as follows. In addition, a positive control can be set up using the SARS-CoV-2 control RNA. A negative control with Isothermal Amplification Buffer, MgSO4, dNTPs, Lateral Flow Reporter, and sample should also be set up to control for DNAse contamination that may produce false positive results.

TABLE 8 Reagent Amount (μL) Sherlock mastermix 45 Lysed sample  5 Total 50

Mix thoroughly and incubate each reaction at 60° C. for 1 hour. Spin down the reaction in a centrifuge at maximum speed. Transfer the reaction tubes to the post-amplification area before proceeding to Step (3).

Step (3)— Visual readout of detection result via lateral flow strip. *PERFORMED IN THE POST-AMPLIFICATION AREA*

Before opening each tube, spin down each reaction tube in a centrifuge at maximum speed to prevent aerosol contamination. Place a HybriDetect Dipstick into each reaction tube and wait for the reaction to flow through the dipstick.

Positive control samples should show the top line and a faint bottom line. Negative control samples should show the bottom line.

For each test sample, check to see the top line appears, indicating positive SARS-CoV-2 detection.

Additional Information

A detailed general protocol for setting up SHERLOCK-based detection can be found in the following reference: SHERLOCK: nucleic acid detection with CRISPR nucleases. Kellner M J, Koob J G, Gootenberg J S, Abudayyeh 00, and Zhang F. Nature Protocols. 2019 October; 14(10):2986-3012. doi: 10.1038/s41596-019-0210-2.

CONCLUSIONS

Applicants' one-pot SHERLOCK detection method is capable of rapid, point-of-care diagnosis of COVID-19. With 97% sensitivity and 100% specificity on patient samples, Applicants were able to detect presence of SARS-CoV-2 down to 100 molecules of viral genome per reaction in a simplified format that any user could perform in a non-laboratory setting. Because of the rapid speed and lack of instrumentation, it is envisioned that this protocol could be used in low resource clinics, workplaces, and even at home. While Applicants tested on nasopharyngeal swabs, saliva samples have similar viral loads and would be a simpler alternative sample source. Future versions of the protocol could benefit from an all-in-one integrated device that could heat the reaction and transfer the reaction to a paper strip to reduce amplicon spread and streamline the workflow.

TABLE 9 Methods Comparison. SHERLOCKv2, CDC RT- SARS- LAMP/AapCas1 SHERLOCKv1, SARS-Cov2 Cov2 2b RPA-Cas13 DETECTR qRT-PCR Reference This study (Zhang et al. (Broughton (CDC) 2020) et al., 2020) Target N gene N gene and S E gene and N N gene gene gene LoD 100 copies 50-500 copies 50 copies 5-15 copies (per 50 ul reaction) Assay reaction 60 min 55 min 40 min 120 min time Assay 70 min 90 min 75 min 4 h sample- to-result time (including RNA (including RNA (including RNA extraction) extraction) extraction) Assay Visual Visual Visual Fluorescent results Laboratory None Centrifuges, Centrifuges, Centrifuges, instru- water baths water baths qPCR mentation machine required Sample None Yes Yes Yes extraction required Liquid transfer 1 3 3 1 steps

REFERENCES

Broughton, J. P., Deng, X., Yu, G., Fasching, C. L., Servellita, V., Singh, J., Miao, X., Streithorst, J. A., Granados, A., Sotomayor-Gonzalez, A., et al. (2020). CRISPR-Cas12-based detection of SARS-CoV-2. Nat. Biotechnol.

Ding, X., Yin, K., Li, Z., and Liu, C. (2020). All-in-One Dual CRISPR-Cas12a (AIOD-CRISPR) Assay: A Case for Rapid, Ultrasensitive and Visual Detection of Novel Coronavirus SARS-CoV-2 and HIV virus.

Gootenberg, J. S., Abudayyeh, O. O., Lee, J. W., Essletzbichler, P., Dy, A. J., Joung, J., Verdine, V., Donghia, N., Daringer, N. M., Freije, C. A., et al. (2017). Nucleic acid detection with CRISPR-Cas13a/C2c2. Science 356, 438-442.

Gootenberg, J. S., Abudayyeh, O. O., Kellner, M. J., Joung, J., Collins, J. J., and Zhang, F. (2018). Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6. Science 360, 439-444.

Guo, L., Sun, X., Wang, X., Liang, C., Jiang, H., Gao, Q., Dai, M., Qu, B., Fang, S., Mao, Y., et al. (2020). SARS-CoV-2 detection with CRISPR diagnostics.

Lucia, C., Federico, P.-B., and Alejandra, G. C. (2020). An ultrasensitive, rapid, and portable coronavirus SARS-CoV-2 sequence detection method based on CRISPR-Cas12.

Shmakov, S., Abudayyeh, O. O., Makarova, K. S., Wolf, Y. I., Gootenberg, J. S., Semenova, E., Minakhin, L., Joung, J., Konermann, S., Severinov, K., et al. (2015). Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems. Mol. Cell 60, 385-397.

Teng, F., Cui, T., Feng, G., Guo, L., Xu, K., Gao, Q., Li, T., Li, J., Zhou, Q., and Li, W. (2018). Repurposing CRISPR-Cas12b for mammalian genome engineering. Cell Discov 4, 63.

Whitman, J. D., Hiatt, J., Mowery, C. T., Shy, B. R., Yu, R., Yamamoto, T. N., Rathore, U., Goldgof, G. M., Whitty, C., Woo, J. M., et al. (2020). Test performance evaluation of SARS-CoV-2 serological assays. medRxiv 2020.04.25.20074856.

Zhang, Y., Odiwuor, N., Xiong, J., Sun, L., Nyaruaba, R. O., Wei, H., and Tanner, N. A. (2020). Rapid Molecular Detection of SARS-CoV-2 (COVID-19) Virus RNA Using Colorimetric LAMP. medRxiv 2020.02.26.20028373.

Example 7— Optimization and Enhancement of Detection Methods

Rather than a multi-step process for the extraction and washing when using beads as is explained in previous prior art methods, the present disclosure improves upon the methods:

A bead and lysis buffer mix is added to the sample, for about 5 to 10 minutes. At this time, the virus is lysed and bound to the beads.

Sample with beads is placed upon magxit, after separation, supernatant is aspirated and reaction buffer mix is added and sample can be subjected in pPCR. Thus, lysis and bead preparation steps are merged rather than multi-steps, and elimination of washes and elution steps are eliminated, with elution merged with the addition of reaction buffer mix.

The bead mix can include potassium chloride, with the typical amount of potassium chloride being reduced or eliminated from the reaction buffer mix. Additionally, the lysis buffer according to methods as provided herein can comprise proteinase K. Without the typical wash steps utilized after lysis, proteinase K carries over from the lysis step in the current methods, and proteinase K inhibitor is added to the reaction buffer mix.

Beads can be optionally used with the methods described herein, including with the one-pot methods that allow for concentration of viral nucleic acids from large volume samples, such as saliva or swab samples to allow for a single one-pot reaction method.

An exemplary method of making the beads are as follows:

Reagents

500 mL 5M NaCl

1M Tris-HCl, pH 8.0

500 mM EDTA, pH 8.0

Dry Poly-Ethylene Glycol 8000, PEG-8000 (Fisher, P/N BP233-1)

Carboxy-Modified Sera-Mag Speed Beads (Fisher, P/N 09-981-124)

Protocol

Vortex the Sera-Mag speedbeads bottle for 1 minutes.

Add 0.1% (w/v) of your intended production amount, which is 10 mL of the Sera-Mag Speedbeads solution to a 50 mL conical tube.

Using a 50 mL magnetic separator, pellet the magnetic beads.

Aspirate the supernatant and discard.

The beads contain residual azide. Wash them twice with 10 mL of DI water, resuspending the pellet each time by vortexing for 30 seconds.

Pellet the beads for the last time.

Prepare the bead buffer by mixing orderly the following in a 500 mL reagent bottle.

Component Volume 5M NaCl 100 mL 1M Tris-HCl  5 mL 500 mM EDTA  1 mL PEG-8000  90 g

Invert mix 10 times and fill with DI water until it reaches the 500 mL mark.

Filter using a vacuum filtration unit according to the manufacturer's instructions and store filtered buffer in container of filtration unit until needed.

Remove the final wash fluid on the beads and add 10 mL of the sterile bead buffer to the beads.

Vortex for 30 seconds to resuspend the beads.

Add the bead slurry to the 500 mL bottle containing the remainder of the sterile buffer.

Twirl the bottle to homogenize the beads with the buffer.

The beads can now be aliquoted and stored at −20° C.

Optimization of reagents For ease of reference, optimization is described using LAMP amplification, but the design paradigm is applicable to any other isothermal amplification approach detailed herein. Further optimization of the methods as disclosed herein can include first screening primers to identify one or more sets of primers that work well for a particular target, Cas protein and/or reaction. Once the primers have been screened, titration of Magnesium concentration can be performed to identify an optimal magnesium concentration for higher signal to noise. Once an optimum magnesium concentration is identified, additional additives are screened at around 20-25% of the reaction, and once additives are identified, these additives, such as those components identified in FIG. 17 , can be evaluated and varied in concentration to identify optimal reaction kinetics for specific reaction parameters, for example, specific primers, target, Cas protein, temperature, and other additive concentrations within the reaction. As described herein, a change form NaCl to KCl allows for the bead and lysis buffer mix to and reduce carryover and optimize reactions, allowing for merger of bead preparation, and washing/elution steps. Additionally, optimization of salt types and concentrations may further aid one-pot reactions.

Example 8— BrCas12b

Further investigations utilizing BrCas12b were performed. While BrCas12b had been previously identified (see, Tian et al., In. J. Biol Marcomol. 2020 Mar. 15, 147:376-384; doi:10.1016/jbiomac.2020.01.079), it was unclear whether the protein would demonstrate sufficient collateral activity and, moreover, whether it would perform in the instant diagnostic application. In particular, it was unclear whether BrCas12b could be utilized at higher temperatures using the LAMP protocls disclosed herein and achieve collateral detection.

As shown in FIG. 46 , BrCas12b is active with the crRNA design disclosed herein and described tracrRNA design. BrCas12b performs well in the 60-70C degree, as exhibited by the measured temperature gradient at 15, 30, 60 and 120 minutes (FIG. 47 ). When using preincubation of 30 minutes at 60C, BrCas12b is shown to more stable than AapCas12b, as pre-incubation of AapCas12b causes denaturation whereas BrCas12b is still active (FIG. 48 ). BrCas12b can achieve rapid detection in less than 20 minutes down to 200 aM for multiple LAMP primer sets specific to N or S gene of coronavirus (FIG. 49 ). Reporter choice for BrCas12b is important, as less signal is achieved with the WCV329 reporter, sequence shown in Table 10. N set 6 LAMP primers utilized in this Example are as shown in Table 5. Optimization of reporter can also be included in the reagent and additive optimization detailed elsewhere herein.

TABLE 10 Plasmid, Guide and Primer Sequences pCV0001 His6- MAVKSIKVKLRLDDMPEIRAGLWKLHKEVNAGVRYYTEWLSLLRQENLYRRSPNG TwinStrep- DGEQECDKTAEECKAELLERLRARQVENGHRGPAGSDDELLQLARQLYELLVPQA SUMO- IGAKGDAQQIARKFLSPLADKDAVGGLGIAKAGNKPRWVRMREAGEPGWEEEKE AacC2c1 KAETRKSADRTADVLRALADFGLKPLMRVYTDSEMSSVEWKPLRKGQAVRTWDR (originally DMFQQAIERMMSWESWNQRVGQEYAKLVEQKNRFEQKNFVGQEHLVHLVNQ pR0280) LQQDMKEASPGLESKEQTAHYVTGRALRGSDKVFEKWGKLAPDAPFDLYDAEIK NVQRRNTRRFGSHDLFAKLAEPEYQALWREDASFLTRYAVYNSILRKLNHAKMFA TFTLPDATAHPIWTRFDKLGGNLHQYTFLFNEFGERRHAIRFHKLLKVENGVAREV DDVTVPISMSEQLDNLLPRDPNEPIALYFRDYGAEQHFTGEFGGAKIQCRRDQLA HMHRRRGARDVYLNVSVRVQSQSEARGERRPPYAAVFRLVGDNHRAFVHFDKLS DYLAEHPDDGKLGSEGLLSGLRVMSVDLGLRTSASISVFRVARKDELKPNSKGRVP FFFPIKGNDNLVAVHERSQLLKLPGETESKDLRAIREERQRTLRQLRTQLAYLRLL VRCGSEDVGRRERSWAKLIEQPVDAANHMTPDWREAFENELQKLKSLHGICSDKEW MDAVYESVRRVWRHMGKQVRDWRKDVRSGERPKIRGYAKDVVGGNSIEQIEYLER QYKFLKSWSFFGKVSGQVIRAEKGSRFAITLREHIDHAKEDRLKKLADRIIMEAL GYVYALDERGKGKWVAKYPPCQLILLEELSEYQFNNDRPPSENNQLMQWSHRGV FQELINQAQVHDLLVGTMYAAFSSRFDARTGAPGIRCRRVPARCTQEHNPEPFP WWLNKFVVEHTLDACPLRADDLIPTGEGEIFVSPFSAEEGDFHQIHADLNAAQNL QQRLWSDFDISQIRLRCDWGEVDGELVLIPRLTGKRTADSYSNKVFYTNTGVTYYE RERGKKRRKVFAQEKLSEEEAELLVEADEAREKSVVLMRDPSGIINRGNWTRQKEF WSMVNQRIEGYLVKQIRSRVPLQDSACENTGDI* (SEQ ID NO: 62031) pCV0002 MAVKSMKVKLRLDNMPEIRAGLWKLHTEVNAGVRYYTEWLSLLRQENLYRRSPN His6- GDGEQECYKTAEECKAELLERLRARQVENGHCGPAGSDDELLQLARQLYELLVPQ TwinStrep- AIGAKGDAQQIARKFLSPLADKDAVGGLGIAKAGNKPRWVRMREAGEPGWEEE SUMO- KAKAEARKSTDRTADVLRALADFGLKPLMRVYTDSDMSSVQWKPLRKGQAVRT AapCas12b WDRDMFQQAIERMMSWESWNQRVGEAYAKLVEQKSRFEQKNFVGQEHLVQL VNQLQQDMKEASHGLESKEQTAHYLTGRALRGSDKVFEKWEKLDPDAPFDLYDT EIKNVQRRNTRRFGSHDLFAKLAEPKYQALWREDASFLTRYAVYNSIVRKLNHAK MFATFTLPDATAHPIWTRFDKLGGNLHQYTFLFNEFGEGRHAIRFQKLLTVEDGV AKEVDDVTVPISMSAQLDDLLPRDPHELVALYFQDYGAEQHLAGEFGGAKIQYRR DQLNHLHARRGARDVYLNLSVRVQSQSEARGERRPPYAAVFRLVGDNHRAFVHFDK LSDYLAEHPDDGKLGSEGLLSGLRVMSVDLGLRTSASISVFRVARKDELKPNSEG RVPFCFPIEGNENLVAVHERSQLLKLPGETESKDLRAIREERQRTLRQLRTQLAYL RLLVRCGSEDVGRRERSWAKLIEQPMDANQMTPDWREAFEDELQKLKSLYGICGDR EWTEAVYESVRRVWRHMGKQVRDWRKDVRSGERPKIRGYQKDVVGGNSIEQIEYL ERQYKFLKSWSFFGKVSGQVIRAEKGSRFAITLREHIDHAKEDRLKKLADRIIME ALGYVYALDDERGKGKWVAKYPPCQLILLEELSEYQFNNDRPPSENNQLMQWSHR GVFQELLNQAQVHDLLVGTMYAAFSSRFDARTGAPGIRCRRVPARCAREQNPEP FPWWLNKFVAEHKLDGCPLRADDLIPTGEGEFFVSPFSAEEGDFHQIHADLNAAQ NLQRRLWSDFDISQIRLRCDWGEVDGEPVLIPRTTGKRTADSYGNKVFYTKTGVTY YERERGKKRRKVFAQEELSEEEAELLVEADEAREKSVVLMRDPSGIINRGDWTRQK EFWSMVNQRIEGYLVKQIRSRVRLQESACENTGDI* (SEQ ID NO: 62032) pCV0003 His6- MPVRSFKVKLVTRSGDAEHMLQLRRGLWKTHEIVNQGIAYYMNKLALMRQEPY TwinStrep- AGKSREVVRLELLHSLRAQQKRNNWTGDAGTDDEILNLSRRLYELLVPSAIGEKGD SUMO- AQMLSRKFLSPLVDPNSEGGKGTAKSGRKPRWMKMREEGHPDWEAEREKDRA BrCas12b, KKAADPTASILNDLEAFGLRPLFPLFTDEQKGIQWLPKQKRQFVRTFDRDMFQQA extra C-term LERMLSWESWNRRVAEEYQKLQAQRDELYAKYLADGGAWLEALQSFEKQREVEL extension AEESFAAKSEYLITRRQIRGWKQVYEKWSQLPEHAAQEQFWQVVADVQTSLPGA FGDPKVYQFLSQPEHHHIWRGYPNRLFHYSDYNGVRKKLQRARHDATFTLPDPVE HPLWIRFDARGGNIHDYEISQNGKQYQVTFSRLLWPENETWVERENVTVAIGAS QQLKRQIRLDGYADKKQKVRYRDYSSGIELTGVLGGAKIQFDRRHLRKASNRLADG ETGPVYLNVVVDIEPFLAMRNGRLQTPIGQVLQVNTKDWPKVTGYKPAELISWIQ NSPLAVGTGVNTIEAGMRVMSVDLGQRSAAAVSIFEVMRQKPAEQETKLFYPIAV TGLYAVHRRSLLLRLPGEKISDEIEQQRKIRAHARSLVRYQIRLLADVLRLHTRGTAE QRRAKLDELLATLQTKQELDQKLWQTELEKLFDYIHEPAERWQQALVAAHRTLEP VIGQAVRHWRKSLRIDRKGLAGMSMWNIEELEETRKLLIAWSKHSRVPGEPNRLD KEETFAPQQLQHIQNVKDDRLKQMANLLVMTALGYKYDEAEKQWKEAYPACQ MILFEDLSRYRFALDRPRRENNRLMKWAHRSIPRLVYLQGELFGIQVGDVYSAYTS RFHAKTGAPGIRCHALKEEDLQPNSYVVKQLIKDGFIREDQTGSLKPGQIVPWSGG ELFVTLADRSGSRLAVIHADINAAQNLQKRFWQQNTEIFRVPCKVTTSGLIPAYDK MKKLFGKGYFAKINQTDTSEVYVWEHSAKMKGKTTPADPAEEGVFDESLTDEME ELEDSQEGYKTLFRDPSGFFWSSDRWLPQKEFWFWVKRRIEKKLREQLQAAALEA RKEAELAAATAEQ*(SEQ ID NO: 62033) pCV0004 His6- MPVRSFKVKLVTRSGDAEHMLQLRRGLWKTHEIVNQGIAYYMNKLALMRQEPY TwinStrep- AGKSREWRLELLHSLRAQQKRNNWTGDAGTDDEILNLSRRLYELLVPSAIGEKGD SUMO- AQMLSRKFLSPLVDPNSEGGKGTAKSGRKPRWMKMREEGHPDWEAEREKDRA BrCas12b, KKAADPTASILNDLEAFGLRPLFPLFTDEQKGIQWLPKQKRQFVRTFDRDMFQQA extra C-term LERMLSWESWNRRVAEEYQKLQAQRDELYAKYLADGGAWLEALQSFEKQREVEL extension AEESFAAKSEYLITRRQIRGWKQVYEKWSQLPEHAAQEQFWQVVADVQTSLPGA FGDPKVYQFLSQPEHHHIWRGYPNRLFHYSDYNGVRKKLQRARHDATFTLPDPVE HPLWIRFDARGGNIHDYEISQNGKQYQVTFSRLLWPENETWVERENVTVAIGAS QQLKRQIRLDGYADKKQKVRYRDYSSGIELTGVLGGAKIQFDRRHLRKASNRLADG ETGPVYLNVVVDIEPFLAMRNGRLQTPIGQVLQVNTKDWPKVTGYKPAELISWIQ NSPLAVGTGVNTIEAGMRVMSVDLGQRSAAAVSIFEVMRQKPAEQETKLFYPIAV TGLYAVHRRSLLLRLPGEKISDEIEQQRKIRAHARSLVRYQIRLLADVLRLHTRGT AEQRRAKLDELLATLQTKQELDQKLWQTELEKLFDYIHEPAERWQQALVAAHRTL EPVIGQAVRHWRKSLRIDRKGLAGMSMWNIEELEETRKLLIAWSKHSRVPGEPNR LDKEETFAPQQLQHIQNVKDDRLKQMANLLVMTALGYKYDEAEKQWKEAYPACQ MILFEDLSRYRFALDRPRRENNRLMKWAHRSIPRLVYLQGELFGIQVGDVYSAYTS RFHAKTGAPGIRCHALKEEDLQPNSYVVKQLIKDGFIREDQTGSLKPGQIVPWSGG ELFVTLADRSGSRLAVIHADINAAQNLQKRFWQQNTEIFRVPCKVTTSGLIPAYDK MKKLFGKGYFAKINQTDTSEVYVWEHSAKMKGKTTPADPAEEGVFDESLTDEME ELEDSQEGYKTLFRDPSGFFWSSDRWLPQKEFWFWVKRRIEKKLREQLQ* (SEQ ID NO: 62034) WCV0328 /5HEX/AAAAA/3IABkFQ/ /5HEX/AAAAA/ 3IABkFQ/ homopolymer hex probe WCV0329 /5HEX/TTTTT/3IABkFQ/ /5HEX/TTTTT/ 3IABkFQ/ homopolymer hex probe N set 6 guide 3 gttagtggaaatgtagatggttagcacgccgcaaattgcacaatttgcccccagcgc (SEQ ID NO: BrCas12b 62035) N set 6 guide 3 GUCUAGAGGACAGAAUUUUUCAACGGGUGUGCCAAUGGCCACUUUCCAGG AapCas12b UGGCAAAGCCCGUUGAGCUUCUCAAAUCUGAGAAGUGGCACCGAAGAACG CUGAAGCGCUG (SEQ ID NO: 62036) OA N set 20 TAGTGGAAATGTAGATGGTTAGCACGCCGCAAATTGCACAATTTG (SEQ ID guide 2 NO: 62037) BrCas12b JJ S Set 19 TAGTGGAAATGTAGATGGTTAGCACCTGACACTACTGATGCTGTC (SEQ ID guide 7 NO: 62038) BrCas12b N set 6 guide Gcgctgggggcaaattgtgcaatttgcggcgtgctaaccatctacatttccactaacccctatagtgagt template 3 cgtattaatttc (SEQ ID NO: 62039) BrCas12b N set 6 guide cagcgcttcagcgttcttoggtgccacttctcagatttgagaagctcaacgggctttgccacctggaaa template 3 gtggccattggcacacccgttgaaaaattctgtcctctagacccctatagtgagtcgtattaatttc AapCas12b (SEQ ID NO: 62040) OA N set 20 caaattgtgcaatttgcggcgtgctaaccatctacatttccactaccctatagtgagtcgtattaatttc guide template (SEQ ID NO: 62041) 2 BrCas12b JJ S Set 19 gacagcatcagtagtgtcaggtgctaaccatctacatttccactaccctatagtgagtcgtattaatttc guide template (SEQ ID NO: 62042) 7 BrCas12b OA N set 20 mix of N set 20 primers as provided below LAMP primer set OA N set 20 AACAAACCCAAGGAAATTTTGG (SEQ ID NO: 62043) F3 OA N set 20 TATTCAGCAAAATGACTTGATCT (SEQ ID NO: 62044) B3 OA N set 20 CATTCCGAAGAACGCTGAAGCACTAATCAGACAAGGAACTGA (SEQ ID NO: FIP(F1c + F2) 62045) OA N set 20 CGCATTGGCATGGAAGTCACATCCAATTTGATGGCACCTG (SEQ ID NO: BIP(B1c + B2) 62046) OA N set 20 CAATTTGCGGCCAATGTTTGT (SEQ ID NO: 62047) LoopF JJ S Set 19 mix of S set 19 primers as provided below LAMP primer set JJ S Set 19 F3 TTCAATGGTTTAACAGGCAC (SEQ ID NO: 62048) JJ S Set 19 B3 CCAAGTAGGAGTAAGTTGATCT (SEQ ID NO: 62049) JJ S Set 19 TCAGTAGTGTCAGCAATGTCTAGGTGTTCTTACTGAGTCTAAC (SEQ ID NO: FIP(F1c + F2) 62050) JJ S Set 19 CAGACACTTGAGTTCTTGACAGGTTAGAAGTATTTGTTCCTGG (SEQ ID NO: BIP(B1c + B2) 62051) JJ S Set 19 CCAAATTGTTGGAAAGGCAG (SEQ ID NO: 62052) LoopF JJ S Set 19 TGGTGGTGTCAGTGTTATAAC (SEQ ID NO: 62053) LoopB

Example 9— LAMP-OSD

The present example explores the use of OSD with LAMP amplification. The OSD probe comprises two complementary probes, which utilizes a fluor and quencher strand. The fluor strand comprises a sequence specific target-binding probe such that separation of the fluorophore and quencher induces a change in fluorescence intensity. Advantageously, the OSD probes can distinguish SNPs in LAMP amplicons.

TABLE 11 N set 6 probe designs ID Sequence Probe set WCV0606 /56-FAM/CCCAAGGAAATTTTGGGG N6-F1 ACCAGGAACTAATCAGA/3InvdT/ (SEQ ID NO: 62054) WCV0607 CCTGGTCCCCAAAATTTCCTTGGG/ N6-Q1 3IABkFQ/ (SEQ ID NO: 62055) WCV0608 /56-FAM/TCTGATTAGTTCCTGGT N6-F2 CCCCAAAATTTCCTTGGG/3InvdT/ (SEQ ID NO: 62056) WCV0609 TTTGGGGACCAGGAACTAATCAGA/ N6-Q2 3IABkFQ/ (SEQ ID NO: 62057) WCV0610 /56-FAM/CAGTTCCCGAAGGTGT N6-F3 GACTTCCATGCCAATGCGC/ 3InvdT/ (SEQ ID NO: 62058) WCVO611 TGGAAGTCACACCTTCGGGAACTG/ N6-Q3 3IABkFQ/ (SEQ ID NO: 62059) WCV0612 /56-FAM/GTGCGCATTGGCATGG N6-F4 AAGTCACACCTTCGGGAAC /3InvdT/ (SEQ ID NO: 62060) WCV0613 TGTGACTTCCATGCCAATGCGCAC N6-Q4 /3IABkFQ/ (SEQ ID NO: 62061)

Use of OSD probe design was explored with COVID-19 LAMP specific probes. Several probe sets were explored in the LAMP-OSD detection assay at 21 minutes. As showing in FIG. 51 , probe set 4 works best. Next, finding the best concentration for probe set 4 in the LAMP-OSD assays at 21 minutes and 28 minutes (FIG. 52 ). The 150 nM probe set 4 shows fastest and most sensitive detection with high signal to noise. Interestingly, the 75 nM probe set seems to achieve 10-fold higher sensitivity down to 10 copies per reaction (FIG. 52 ).

Example 10

Integrating isothermal amplification with CRISPR-mediated detection required developing an optimal common reaction chemistry supporting both steps, as has been described in the previous examples. In summary, to amplify viral RNA, reverse transcription was chosen followed by Loop-mediated isothermal amplification (RT-LAMP)⁴ because LAMP reagents are widely available and use defined buffers amenable to Cas enzymes. LAMP operates at 55-65° C., requiring a thermostable Cas enzyme, such as Cas12b from Alicyclobacillus acidiphilus (AapCas12b)⁵. Different LAMP primer sets and AapCas12b guide RNAs (a guide RNA helps AapCas12b recognize and cut target DNA) were systematically evaluated to identify the best combination to target gene N, encoding the SARS-CoV-2 nucleocapsid protein, in a one-pot reaction (FIG. 17, 25E, 54A-56B). This assay is referred to herein in STOPCovid.v1. As expected, STOPCovid.v1 detection produced signal only when the target is present, whereas LAMP alone can produce nonspecific signal (FIG. 56B). STOPCovid.v1 is compatible with lateral flow and fluorescence readouts and can detect an internal control using fluorescence readout (FIGS. 57A-59H).

To simplify RNA extraction and boost sensitivity, Applicants adapted a magnetic bead purification method (FIG. 62A-62E). The magnetic beads could concentrate SARS-CoV-2 RNA genomes from the entire nasopharyngeal or anterior nasal swab into one STOPCovid reaction. Applicants optimized the workflow by combining the lysis and magnetic bead—binding steps and eliminating the ethanol wash and elution steps to reduce sample extraction to 15 minutes with minimal hands-on time. This streamlined workflow is referred to herein as STOPCovid.v2 (FIG. 53A).

Applicants compared STOPCovid.v2 to the standard CDC workflow (RNA extraction followed by RT—qPCR) using SARS-CoV-2 virus-like particles (FIG. 63C). Concentration of substrate by magnetic beads in STOPCovid.v2 allowed detection of viral RNA from the entire sample obtained by swab: a 600-fold higher input (in terms of quantity of viral RNA) than is afforded by the CDC workflow. As a result, STOPCovid.v2 could reliably detect 30-fold lower viral load than the CDC RT-qPCR workflow (100 copies per sample, or 33 copies per mL, compared to 1,000 copies per mL). Analysis of two independent nasopharyngeal swab sample dilution series revealed that STOPCovid.v2 has a limit of detection comparable to an RT-qPCR Ct value of 40.3 (FIG. 63D, 63E).

Blinded testing by an external laboratory at the University of Washington using 202 SARS-CoV-2 positive and 200 negative manufactured patient nasopharyngeal swab samples showed that the sensitivity and specificity of STOPCovid.v2 were 93.1% and 98.5%, respectively (FIG. 53B, 53C, FIG. 64A, and Table 12).

RT-qPCR STOPCovid.v2 Pos. Neg. Total Predictive value Pos. 188 3 191 PPV = 98.4% Neg. 14 197 211 NPV = 93.4% Total 202 200 Sensitivity Specificity 93.1% 98.5% Swabs were prepared according to the FDA's recommendation for simulating fresh swabs for regulatory applications.) STOPCovid.v2 false-negative samples had RT-qPCR Ct values greater than 37. Positive samples were detected in 15 to 45 mins. Finally, STOPCovid.v2 was validated using fresh, dry anterior nasal swabs (FIGS. 64B-64E) and correctly identified 5 positive samples (Ct values ranging from 19 to 36). Provided in this example is a detailed protocol for STOPCovid.v2.

The simplified format of STOPCovid. V2 is suited to deployment in low-complexity clinical laboratories or low-cost diagnostic development, and its high sensitivity may afford some leeway in sample collection.

Here Applicants describe in more detail the rationale and results that contributed to the development of STOPCovid. Applicants first simplified the viral RNA extraction method. Most clinical labs currently perform an RNA extraction step using commercial RNA extraction kits, which requires multiple fluid handling steps and relies on reagents that have been difficult to obtain steady supplies of. To eliminate this step, Applicants tested various viral lysis buffers for extraction of lentiviral RNA and added the lysate directly into RT-qPCR reactions (FIG. 54A, 54B). Applicants found that addition of DNA QuickExtract to COVID-19 positive patient nasopharyngeal (NP) swab viral transport media (VTM) followed by heating at 95° C. for 5 mins was comparable to the standard QIAmp Viral RNA Miniprep extraction (FIG. 54C).

Integrating the isothermal amplification step with the CRISPR-mediated detection step required developing an optimal common reaction chemistry capable of supporting both steps (FIG. 54D). To amplify the viral RNA, reverse transcription was chosen followed by Loop-mediated isothermal amplification (RT-LAMP)¹⁶. While Recombinase polymerase amplification was the focus²² in the past^(1,2,5), LAMP reagents are readily available from multiple commercial suppliers, are easily multiplexed²³, and rely on defined buffers that are amenable to optimization with Cas enzymes. Applicants designed 29 sets of LAMP primers targeting different regions of the SARS-CoV-2 genome and identified 6 primer sets targeting genes ORF lab, S, and N that were capable of SARS-CoV-2 RNA detection (FIG. 54E).

LAMP operates at 55-65° C., requiring a thermostable Cas enzyme for a one-pot chemistry, such as Cas12b from Alicyclobacillus acidiphilus (AapCas12b)¹⁷. The AapCas12b locus does not contain an identifiable CRISPR array, but it can function up to 65° C. with a single guide RNA (sgRNA) based on the direct repeat from Alicyclobacillus macrosporangiidus Cas12b (AmCas12b)¹⁷ (FIG. 55A). Replacing the AmCas12b sgRNA with an sgRNA from Alicyclobacillus acidoterrestris Cas12b (AacCas12b) (Shmakov et al., 2015), which is highly similar to AapCas12b, produced more robust and specific nuclease activity, possibly due to the stronger hairpin formed near the 3′ end of the sgRNA (FIG. 55B, 55C).

Applicants next systematically evaluated all possible spacers targeting the top LAMP amplicons to identify the ideal combination of primers and guide sequence (FIG. 55D). For the top 4 combinations of LAMP primer set and guide, Applicants titrated the concentration of magnesium in a one-pot reaction to find the best combination of buffer, primer set, and guide, yielding an assay targeting gene N (FIG. 55E). For this assay, it was found that all 6 LAMP primers and spacer targeting regions were perfectly conserved in at least 99.5% of >31,000 sequenced human SARS-CoV-2 genomes²⁴.

Using these conditions, both AapCas12b and AacCas12b were tested in a one-pot reaction. Applicants found that AapCas12b generated faster (34 min to half maximum signal compared to 39 min) and stronger collateral activity (1.6 times maximum signal) than AacCas12b in the one-pot reaction (FIG. 25E). Applicants note that although AacCas12b has been reported to work with LAMP in one-pot assays at 55° C.²⁵, it did not provide adequate activity in the assay at 60° C., a temperature more optimally suited for LAMP, possibly because it is unstable at higher temperatures. Applicants further optimized the AapCas12b one-pot reaction by screening 94 additives to improve thermal stability (FIG. 17 ), finding that addition of taurine improved reaction kinetics (FIG. 56A, 17 ). Applicants termed this optimized one-pot assay STOP and its application for SARS-CoV-2 detection STOPCovid. As expected, STOPCovid detection produces signal only when the target is present, whereas LAMP alone (either as a stand-alone reaction or in the STOPCovid mastermix) can produce nonspecific signal (FIG. 56B), highlighting the additional specificity provided by CRISPR detection.

Applicants used STOPCovid.v1 with a lateral flow readout and SARS-CoV-2 genome standards spiked into pooled healthy saliva or NP swab VTM to determine the sensitivity, robustness, ideal incubation temperature, and readout time of the assay. Applicants found that the STOPCovid.v1 chemistry can detect 100 copies of SARS-CoV-2 per reaction and reproducibly detect 200 copies over 30 replicates (FIG. 57A, 57B). STOPCovid.v1 detection was stochastic below 100 copies per reaction and produced variable signal levels between replicates, potentially resulting from variability in the timing of LAMP (FIG. 57A, 57B). The ideal incubation parameters were 60° C. for at least 50 minutes for lateral flow, though longer incubation times do not affect the results (FIG. 26A, 26B). The reaction components could be formulated as a mastermix, which maintained functionality after 6 freeze-thaw cycles (FIG. 26C). The assay exhibited no cross-reactivity with the SARS-CoV or MERS-CoV genomes (FIG. 26D) and could be performed using either a standard heat block or via a water bath maintained by a commercially-available, low-cost (under $40 USD), sous-vide cooker (FIG. 41 ).

In addition to lateral flow readout, STOPCovid.v1 is also compatible with fluorescence readout, which allows for simultaneous detection of an internal control using orthogonal fluorescent dyes. By introducing LAMP primer sets targeting an abundant control gene into the STOPCovid reaction, LAMP amplification signal detected by SYTO 9 nucleic acid stain before 28 minutes indicates specific amplification of human sample, while Cas12b collateral cleavage of a HEX reporter probe indicates presence of SARS-CoV-2. Applicants screened 114 LAMP primers sets targeting ACTB and GAPDH to identify 19 LAMP primer sets that could be multiplexed with the N LAMP primer set at 50% or 20% of the total primer set concentration (FIG. 58 ). The best control LAMP primer set, ACTB Set 1, could be multiplexed with the N gene LAMP primer set at 20% of the total primer amount (FIG. 58 ). Using SARS-CoV-2 genome standards spiked into pooled healthy saliva or NP swabs, Applicants determined the multiplex reaction is sensitive down to 200 copies of SARS-CoV-2 genome per reaction (FIG. 59A-59D). This assay detected 30/30 replicates at 300 genomic copies and 27/30 replicates at 200 genomic copies (FIG. 59E, 59F). Similar to lateral flow, the fluorescent multiplexed assay was most robust at 60° C. (FIG. 59G, 59H).

Applicants then evaluated STOPCovid.v1 with lateral flow readout on 43 SARS-CoV-2 RNA positive (Ct values ranging from 17 to 38) and 15 negative patient NP swab VTM samples. STOPCovid.v1 had a sensitivity of 84% and specificity of 100% for detecting 2 out of 3 replicates for the 43 positive samples (FIG. 35A, C). Samples that tested false negative with STOPCovid.v1 had RT-qPCR Ct values above 32 (FIG. 35A, 60A-60B). Parallel work from the Virology Lab at the University of Washington on 19 positive and 7 negative patient samples showed that STOPCovid.v1 had a sensitivity of 84% and specificity of 100% (FIG. 60C). Patient sample dilution series revealed that STOPCovid.v1 sensitivity comparable to RT-qPCR Ct value of 30.8 (FIG. 60D). In addition, Applicants found that lysis at a lower temperature (60° C. or 22° C.) is a viable alternative for streamlining the STOPCovid.v1 assay workflow, albeit with a slight decrease in sensitivity (increased Ct value of 0.8/0.2 at 60° C. and 1.1/0.9 for 22° C. for CDC N1/N2 probe sets) (FIG. 61A-61C). Together, these results demonstrate the feasibility of detecting SARS-CoV-2 without RNA extraction in a one-pot reaction, but based on the distribution of Ct values for 2,105 SARS-CoV-2 positive patients (FIG. 61D), STOPCovid.v1 would only capture 60.5% of RT-qPCR-positive patients.

Applicants therefore sought to boost sensitivity by increasing sample input via sample concentration. In the initial attempt to simplify viral RNA extraction, Applicants only used 2.5 μL of the 3 mL NP swab VTM (0.083% of the total NP swab sample). Applicants reasoned that capturing all of the viral RNA from an NP or anterior nasal (AN) swab would increase sample input by 1,200-fold and dramatically increase sensitivity. Applicants tested sample concentration using two magnetic bead formulations, laboratory-developed²⁶ and commercial (Beckman SPRIselect), prior to STOPCovid detection. Applicants found that both formulations could efficiently capture viral RNA (SARS-CoV-2 genomic standards spiked into DNA QuickExtract lysis buffer with human background RNA) into one 50 μL STOPCovid reaction using the standard magnetic bead purification method (FIG. 62A). In addition, Applicants determined Applicants could elute the sample from the beads by directly adding STOPCovid mastermix to the magnetic beads without a separate water elution step (FIG. 62A). As the laboratory-developed magnetic beads are significantly cheaper ($0.20 USD/reaction compared to $6.13 USD/reaction) and easier to modify than the commercial version, Applicants moved forward with the laboratory-developed magnetic beads. Applicants found that introducing the bead concentration step increased sensitivity, enabling detection of as little as 100 viral copies per sample compared to 5,000 copies per sample without this step (FIG. 62B).

To streamline the magnetic bead concentration workflow, Applicants eliminated the ethanol wash step and combined the lysis and magnetic bead binding steps by optimizing the salt concentration of the one-pot reaction and testing alternative QuickExtract formulations (FIG. 62C-62E). Using SARS-CoV-2 virus-like particles (SARS-CoV-2 RNA targets in a noninfectious viral coat), Applicants found that Plant QuickExtract combined with magnetic bead binding in a KCl buffer produced the best results in lieu of any washing steps, further simplifying extraction to a total of 15 minutes with minimal hands on time (FIG. 62E). Applicants refer to this streamlined workflow as STOPCovid.v2 (FIG. 53A-53C).

Applicants further optimized the STOPCovid.v2 chemistry by titrating Cas12b and sgRNA concentrations. While characterizing STOPCovid.v2, Applicants noticed that STOPCovid.v2 occasionally produced false positive results. Applicants hypothesized that this was due to partial overlap between the sgRNA and LAMP BIP primer that contributed to sporadic Cas12b collateral activity. Applicants therefore titrated Cas12b and sgRNA concentrations and found that the optimal concentration of Cas12b and sgRNA for reducing the proportion of false positive results while retaining true positive signal was 31.3 nM (FIG. 63A). Applicants verified that this concentration of Cas12b and sgRNA maintained the same sensitivity (FIG. 63B).

Applicants compared STOPCovid.v2 to the standard CDC workflow that uses QIAmp Viral RNA Miniprep extraction followed by RT-qPCR (FIG. 63C). Starting with different concentrations of SARS-CoV-2 virus-like particles, Applicants performed a direct comparison of the two assay workflows. Applicants confirmed that the CDC SARS-CoV-2 RT-qPCR protocol could reliably detect down to 1,000 copies per mL of VTM, the reported limit of detection (LOD) of the assay (fda.gov/media/134922/download). By contrast, STOPCovid.v2 was able to reliably detect viral loads as low as 100 copies per sample (equivalent to 33 copies per mL VTM) for the fluorescence readout and 250 copies (equivalent to 83 copies per mL VTM) for the lateral flow readout. Applicants typically detect positive signal in less than 45 minutes by fluorescence read out and 80 minutes by lateral flow. Introduction of the magnetic bead concentration step in STOPCovid.v2 allowed for detecting viral RNA from the entire swab sample, or 600-fold higher input, than the CDC RT-qPCR workflow. As a result, STOPCovid.v2 could reliably detect 30-fold lower viral load than the CDC RT-qPCR workflow (100 copies per sample, or 33 copies per mL, compared to 1,000 copies per mL). These results suggest that though the STOPCovid.v2 reaction is 20 times less sensitive than the RT-qPCR reaction itself (detects 100 copies per reaction compared to 5 copies per reaction), adding an initial sample concentration in the STOPCovid.v2 workflow resulted in higher overall sensitivity.

Applicants evaluated the performance of the optimized STOPCovid.v2 chemistry on SARS-CoV-2 positive patient samples. Patient NP swab sample dilution series revealed that STOPCovid.v2 had a limit of detection comparable to an RT-qPCR Ct value of 40.3, which could in theory capture 99.7% of SARS-CoV-2 positive patients (FIG. 61D and FIG. 63D, 63E). Blinded testing by an external laboratory at the University of Washington on 202 SARS-CoV-2 positive and 200 negative patient NP swab VTM samples showed that the sensitivity and specificity of STOPCovid.v2 were 93.1% and 98.5% respectively (FIG. 53B, 53C, FIG. 64A, and Table 12). STOPCovid.v2 false negative samples had RT-qPCR Ct values that were greater than 37. Positive samples were detected in 15-45 mins. Finally, Applicants validated STOPCovid.v2 using dry AN swabs. Applicants confirmed that STOPCovid.v2 could detect SARS-CoV-2 virus-like particles spiked into SARS-CoV-2 negative dry AN swabs (FIG. 64B, 64C). STOPCovid.v2 correctly identified 5 SARS-CoV-2 positive patient AN swabs (Ct values ranging from 19 to 36) (FIG. 64D, 64E).

To aid users of STOPCovid, Applicants have developed a mobile phone application to help the user interpret lateral flow results (FIGS. 63C and 65A-65B). Note that lateral flow testing requires opening post-amplification tubes, and users should consider separate pre- and post-amplification workspaces to reduce chances of cross contamination between samples and false positives.

Methods RT-qPCR Reactions

RT-qPCR reactions were performed using the TaqPath 1-Step RT-qPCR Master Mix (ThermoFisher A15300) using TaqMan probes and primer sets (Table 14) and measured on a Roche LightCycler 480. RT-qPCR quantification was performed using the second derivative maximum method from the LightCycler software.

Viral Nucleic Acid Extraction

To compare crude lysis methods with standard RNA extraction methods, viral samples were purified using the QIAamp Viral RNA Mini Kit (Qiagen 52906), using 100 μL sample input and 100 μL elution volume.

Lentiviral Lysis and Quantification

To evaluate crude lysis methods, red fluorescent protein sequence packaged into lentivirus as described previously²⁹ was directly used for downstream quantification or diluted 1:1 in candidate lysis buffers and boiled at 95° C. for 5 minutes. Lysis efficiency was determined using 2 μL of crude sample as input into a 20 μL RT-qPCR reaction, performed as described above.

Mock Clinical Sample Preparation

Nasopharyngeal (NP) swabs from healthy donors (Lee Biosolutions 991-31-NC) were dipped in 2 mL E-MEM (VWR 10128-214) to dislodge material from the swab. NP swabs from 5 patients were pooled to simulate SARS-CoV-2-negative NP swab matrix. Saliva from 5 healthy donors (Lee Bisolution 991-05-S) was pooled together to simulate SARS-CoV-2 negative saliva matrix. Clinical matrices were heated at 95° C. for 5 minutes with an equal volume of QuickExtract DNA Extraction Solution (Lucigen QE09050), followed by the addition of SARS-CoV-2 genomic standards (Twist Biosciences 102019) at indicated concentrations to create mock clinical samples for downstream detection.

Loop-Mediated Isothermal Amplification (LAMP)

LAMP primer sets (Table 15) were designed using LAMP Designer 1.16 (Premier Biosoft) or GLAPD³⁰. LAMP reactions were performed using final concentrations of 1.6 uM FIP/BIP primers, 0.2 uM F3/B3 primers, and 0.4 uM LoopF/B primers. LAMP primer sets were screened using the WarmStart Lamp Kit (New England Biolabs E1700) with 1X fluorescent LAMP dye and 25 ng of background human RNA in 20 μL reactions. RNA targets for LAMP primer screening (Table 15) were transcribed using HiScribe T7 Quick High Yield RNA Synthesis Kit (New England Biolabs E2050). Optimizations of LAMP primer sets selected for further evaluation were performed using 1X Isothermal Amplification Buffer (20 mM Tris-HCl, 50 mM KCl, 10 mM (NH4)2504, 2 mM MgSO4, 0.1% Tween 20, pH 8.8) (New England Biolabs B0537), 1.4 mM dNTPs (New England Biolabs N0447), 6.4 units of Bst2.0 WarmStart DNA Polymerase (New England Biolabs M0538), 6 units of WarmStart RTx Reverse Transcriptase (New England Biolabs M0380), variable concentrations of added MgSO4 (New England Biolabs B1003) and 1X fluorescent LAMP dye in 20 μL reactions containing 10% mock NP clinical sample with SARS-CoV-2 genomic standards. LAMP reactions were performed at 60° C. (unless otherwise indicated) for 1-2 hrs on a qPCR machine (Roche LightCycler 480 or BioRad CFX) with fluorescent measurements every 2 minutes. Cas12b Protein Purification

AacCas12b and AapCas12b orthologs were expressed and purified with a modified protocol³¹. Briefly, AacCas12b (human codon optimized) bacterial expression vector was transformed into BL21-CodonPlus (DE3)-RIPL Competent Cells (Agilent 230280), and AapCas12b bacterial expression vector was transformed into BL21(DE3) Competent E. coli (NEB C2527). Protein sequences for AacCas12b and AapCas12b are provided elsewhere herein. A 12.5 mL starter culture was grown in Terrific Broth media (TB) supplemented with 100 μg/ml ampicillin for 12 h, which was used to inoculate 12 L of TB for growth at 37° C. and 150 rpm until an OD600 of 0.4. After cells were cooled down to 16° C., protein expression was induced by supplementation with IPTG (Goldbio I2481C) to a final concentration of 0.5 mM. The cells were incubated at 16° C. for 16 h for protein expression, and then harvested by centrifugation for 20 min at 4° C. at 4000 rpm (Beckman Coulter Avanti J-E, rotor JLA9.100). Cell pellet was stored at −80° C. for later purification. All subsequent steps were performed at 4° C. Cell pellet was resuspended in 600 mL of lysis buffer (20 mM Tris-HCl, 500 mM NaCl, 1 mM DTT, pH 8.0) supplemented with complete ULTRA Tablets (Millipore sigma 6538282001), 1 mg/mL lysozyme (Sigma L6876), and 250 units/L benzonase (Sigma E1014). Cells were disrupted by the LM20 Microfluidizer system at 18,000 PSI. Lysate was cleared by centrifugation for 30 min at 4° C. at 9500 rpm (Beckman Coulter Avanti J-E, rotor JLA-10.500). The cleared lysate was applied to 5 mL of packed Strep-Tactin Sepharose (IBA 2-1201-010) and incubated with rotation for 1 h, followed by washing of the protein-bound resin in 150 mL of lysis buffer. The resin was resuspended in 15 mL of lysis buffer supplemented with 1.2 mg of Ulp1 SUMO protease, and incubated at 4° C. for 16 h with rotation. The suspension was applied to a column for elution and separation from resin by gravity flow. The resin was washed with 15 mL of lysis buffer, and this additional eluate was combined with the first 15 mL of eluate. The combined 30 mL of eluate was diluted with 30 mL of cation exchange buffer A (20 mM Tris-HCl, 5% glycerol, 1 mM DTT, pH 7.5) to lower the salt concentration for cation exchange chromatography. The resulting 60 mL protein solution was loaded onto a 5 mL HiTrap SP HP cation exchange column (GE Healthcare) via FPLC (AKTA PURE, GE Healthcare) and eluted over a 250 mM to 2 M NaCl salt gradient made by cation exchange buffer A and B (20 mM Tris-HCl, 2 M NaCl, 5% glycerol, 1 mM DTT, pH 7.5). The resulting fractions were tested for presence of the protein by NuPAGE (Invitrogen) and eStain L1 Protein Staining System (GenScript). The fractions containing the protein were pooled and concentrated by an Amicon Ultra-15 Centrifugal Filter Units (50KDa NMWL, Millipore UFC905024) to 1 mL. The concentrated protein was loaded onto a gel filtration column (Superdex 200 Increase 10/300 GL, GE Healthcare) equilibrated with Cas12 protein storage buffer (50 mM Tris-HCl, 600 mM NaCl, 2.5% glycerol, 2 mM DTT, pH 7.5) via FPLC. The resulting fractions from gel filtration were analyzed and the fractions containing the protein were pooled, snap frozen as 2 mg/mL aliquots, and stored at −80° C.

Cas12b Collateral Detection

Cas12b detection reactions were performed using 1X Isothermal Amplification Buffer, 8 mM MgSO₄, 250 nM Cas12b protein, 250 nM sgRNA, 250 nM fluorescent reporter (/5HEX/TTTTT/3IABkFQ/) and 1 μL of completed LAMP reaction in 10 μL reactions. Cas12b detection reactions were performed at 60° C. (unless otherwise indicated) for 1-2 hrs on a qPCR machine (Roche LightCycler 480 or BioRad) with fluorescent measurements every 2 minutes.

One Pot LAMP-Cas12b Fluorescent Reactions

One-pot LAMP-Cas12b reactions were performed using 1X Isothermal Amplification Buffer, 1.4 mM dNTPs, 6.4 units of Bst2.0 WarmStart DNA Polymerase, 6 units of WarmStart RTx Reverse Transcriptase, 250 nM Cas12b protein, 250 nM sgRNA, 200 nM fluorescent reporter, 1.6 uM FIP/BIP primers, 0.2 uM F3/B3 primers, 0.4 uM LoopF/B primers and variable concentrations of MgSO4 in 20 μL reactions. Where indicated, mock clinical sample with SARS-CoV-2 genomic standard was added at 10% of the final reaction volume to simulate crude input from sample lysis. One-pot reactions were performed at 60° C. (unless otherwise indicated) for 1-2 hrs on a qPCR machine (BioRad) with fluorescent measurements every 2 minutes.

Conservation Analysis of STOPCovid Targeting Sites

Human SARS-CoV-2 nucleotide sequences were downloaded from Gisaid database²⁴ on May 30th 2020. Completed genomes (sequence length >29,000 nt and less than 5% of ambiguous nucleotides) were aligned using mafft³² to obtain a global alignment of 31,614 sequences. For each target, Applicantsextracted a sub alignment embedding the region of the target from the genome alignment and removed sequences with ambiguous nucleotides. Then, Applicantsdetermined the number of sequences that either perfectly matched the target or had substitutions and indels.

Additive Screening

Additives from the Hampton Research Solubility and Stability Screen (Hampton Research HR2-072) were added at 20% of the final reaction volume of one-pot LAMP-Cas12b fluorescent detection reactions unless otherwise indicated.

STOPCovid Reactions

STOPCovid reactions were one-pot LAMP Cas12b reactions described above, using N Set 2 LAMP primers, N set 2 AacCas12b sgRNA 11, and 50 mM taurine. When performing lateral flow reactions, the fluorescent reporter was substituted for a lateral flow collateral reporter (/56-FAM/TTTTTTT/3Bio/). Unless otherwise indicated, STOPCovid lateral flow reactions were incubated at 60° C. for one hour. After incubation, a HybriDetect Dipstick (Milenia Biotec GmbH MGHD 1) was added to the reaction and the liquid was allowed to flow to the top of the strip for subsequent detection. The final concentration of the lateral flow collateral reporter was titrated (125-200 nM) on each lot of HybriDetect Dipsticks to achieve maximal signal-to-noise ratio. Sous-Vide cooker (Amazon B07H9N9PMQ) was used where indicated. To maximize sensitivity and specificity, the final Aap Cas12b and sgRNA concentration was titrated to 31.3 nM. This concentration was used for validating STOPCovid.v2 on patient NP and anterior nasal (AN) samples.

STOPCovid Multiplexed Control Reactions

Multiplexed reactions were performed as described for fluorescent STOPCovid reactions, with indicated ratios of N set 2 LAMP primers to control LAMP primers and the addition of 250 nM SYTO-9 Fluorescent Nucleic Acid Stain (ThermoFisher S34854). Total LAMP Primer concentration was consistent between single target and multiplexed STOPCovid reactions.

SARS-CoV-2 Clinical Sample Collection

Nasopharyngeal swabs were collected in PBS, viral transport medium (ThermoFisher Scientific), or universal transport media (Becton Dickinson) and submitted to the Virology Laboratory at the University of Washington. SARS-CoV-2 was detected by a laboratory-developed RT-qPCR test using CDC distributed N1 and N2 gene primer/probe sets or tests from Hologic (Panther Fusion) and Roche (cobas). The Panther Fusion SARS-CoV-2 assay (Hologic) amplifies and detects two regions of ORF lab. The cobas SARS-CoV-2 assay on the 6800 platform (Roche Diagnostics) qualitatively detects two viral targets: ORF lab and E-gene. The averages of the observed Ct values in each test were used to determine the overall Ct value of the SARS-CoV-2 positive samples. Previous studies have shown that the average Ct values between each assay are comparable³³. After analysis, samples were stored at −80° C. until further analysis. Samples from the University of Washington were shipped to the Broad Institute for evaluating STOPCovid.v1 performance.

Estimation of LOD Using Patient Samples

Clinical samples that tested positive for SARS-CoV-2 from the cobas SARS-CoV-2 assay were stored at 4° C. and used within 12 h to determine the LOD. A five-fold serial dilution of SARS-CoV-2 positive patient NP swab samples in UTM (Becton Dickinson) were generated. For STOPCovid.v1, samples were lysed with an equal volume of DNA QuickExtract for 5 mins at 95° C. 5 μL of lysates were used for the STOPCovid.v1 lateral flow reaction and incubated at 60° C. for one hour, following the signal readout using a HybridDetect Dipstick (Milenia). Ct 3.3 was added between the 5-fold dilutions of samples. To estimate the LOD of the STOPCovid.v2 fluorescent reaction of the total NP swab sample, three replicates of five-fold serial dilution of SARS-CoV-2 positive patient NP swab samples in UTM were generated. 50 μL of diluents were transferred to the extraction buffer (260 μL of laboratory-developed KCl magnetic beads, 40 μL of 10X QuickExtract Plant DNA Extraction Solution, and 50 μL water) using foam swabs (Puritan 25-1506). Nucleic acids bound to magnetic beads were subjected to a STOPCovid.v2 reaction at 60° C. on an ABI 7500 qPCR machine (Thermo Fisher) with measurements every 1 min for 45 min. Since 50 μL of the NP swab sample in UTM, out of 3 mL total, were used, Ct 5.9 was added to the observed average Ct value of the original sample, and Ct 3.3 was added between the 5-fold dilutions of samples. To project the proportion of SARS-CoV-2 positive patients that an assay with the estimated LOD could capture, the average Ct values obtained from the dilution series were compared to the larger 2,105 patient Ct values obtained from the cobas RT-qPCR assay.

To evaluate the performance of STOPCovid.v2, a blinded test of 202 SARS-CoV-2 positive samples and 200 negative samples was performed. Similar to the dilution series, as only 50 μL of the NP swab sample in 3 mL of UTM was used instead of the entire swab, Ct 5.9 was added to the observed Ct value of the original sample, and only samples with Ct values lower than 34 were used. 50 μL of randomized and blinded NP swab samples in UTM were transferred to 50 μL of water and 300 μL of extraction buffer. STOPCovid.v2 reaction was performed as described above and fluorescent measurements were taken every 2 min during a 44 min period in an ABI 7500 qPCR machine (Thermo Fisher). Fluorescence threshold for classifying samples as positive or negative was set to approximately 10% of the average steady state fluorescence signal, or 100,000 RFU on the ABI 7500 qPCR machine.

Laboratory-Developed Magnetic Bead Preparation

Laboratory-developed magnetic beads for RNA concentration were prepared as previously described²⁶. Briefly, 10 mL of Sera-Mag SpeedBeads Carboxyl Magnetic Beads Hydrophobic (GE Healthcare 65152105050250) were washed with ddH₂O and resuspended in 500 mL of bead binding buffer (10 mM Tris-HCl pH 8.0, 1M NaCl, 18% PEG-8000, and 1 mM EDTA). Where indicated, 1M NaCl was replaced with 1M KCl.

Bead Extraction and Concentration

400 μL of laboratory-developed or commercial (SPRISelect, Beckman Coulter B23317) magnetic beads were mixed with 200 μL of heat-inactivated (95° C. for 5 minutes). QuickExtract DNA Extraction Solution spiked with indicated quantity of SARS-CoV-2 genomic standard and 1.25 μg of background human RNA. This mixture was allowed to bind for 5 minutes at room temperature, before transfer onto a magnetic plate (Alpaqua A001219). Beads were washed with 1 mL of 70% ethanol, and allowed to dry for 5 minutes. 50 μL of STOPCovid mastermix was directly added to the beads and the reaction mixture was incubated at 60° C. for 1-2 hrs. Where indicated, the washing and drying steps outlined above were skipped and a modified STOPCovid mastermix was used. Specifically, a modified 1X Isothermal Amplification Buffer containing no KCl (20 mM Tris-HCl, 10 mM (NH4)2504, 2 mM MgSO4, 0.1% Tween 20, pH 8.8) was used in place of the buffer described above.

Combination of Lysis and Magnetic Bead Binding

To evaluate the ability to perform efficient viral lysis and nucleic acid binding in parallel, 100 μL of mock SARS-CoV-2 virus (SARS-CoV-2 RNA targets in a noninfectious viral coat) from AccuPlex SARS-CoV-2 Verification Panel (SeraCare 0505-0132) with 125 ng/μL background human RNA were either added to 100 μL of lysis buffer alone or 100 of lysis buffer combined with 400 μL of laboratory-developed KCl magnetic beads. Concentrations of lysis buffers, QuickExtract DNA Extraction Solution and QuickExtract Plant DNA Extraction Solution (Lucigen QEP70750), indicated the final working concentration. Samples containing no magnetic beads were incubated at the indicated temperature for 5 minutes, followed by the addition of 400 μL of laboratory-developed KCl magnetic beads. Samples containing combined bead/lysis mixtures were incubated at room temperature for 10 minutes. All samples were subsequently treated with the bead extraction and concentration steps described above with no wash step.

Comparison of STOPCovid.v2 to CDC RT-qPCR assays

To create mock samples simulating the addition of swabs, different amounts of mock SARS-CoV-2 virus from the AccuPlex SARS-CoV-2 Verification Panel were diluted in PBS containing 25 ng/μL background human RNA. 50 μL of mock sample was either added to extraction buffer (400 μL of laboratory-developed KCl magnetic beads, 60 μL of 10X QuickExtract Plant DNA Extraction Solution, and 90 μL of PBS) for detection with STOPCovid.v2 or to 1 mL E-MEM media for subsequent nucleic acid extraction and RT-qPCR. STOPCovid.v2 fluorescent reactions were incubated at 60° C. on a qPCR machine with measurement every 2 minutes. STOPCovid.v2 lateral flow reactions were allowed to proceed at 60° C. for 80 minutes before addition of a detection strip. RT-qPCR reactions were performed according to CDC recommendations available at fda.gov/media/134922/download, using the N1 primer and probe set.

Evaluation of STOPCovid.v2 Using Dry Anterior Nasal Swabs

SARS-CoV-2 negative patient dry AN swabs (Lee Biosolutions 991-31-NC) were dipped into extraction buffer (260 μL of laboratory-developed KCl magnetic beads, 40 μL of 10X QuickExtract Plant DNA Extraction Solution, and 100 μL water) for detection with STOPCovid.v2. For simulating SARS-CoV-2 positive AN swabs, water in the extraction buffer was replaced with mock SARS-CoV-2 virus from the AccuPlex SARS-CoV-2 Verification Panel. SARS-CoV-2 positive patient dry AN swabs were collected from SARS-CoV-2 positive patients at Brigham and Women's Hospital. SARS-CoV-2 positive patients were identified using NP swabs and the Panther Fusion (Hologic) assay. Dry AN swabs were collected within 48 hours of the NP swab RT-qPCR test. To collect the AN swabs, a flocked AN swab (Miraclean Technology 93050) was inserted approximately 1 inch into the left nostril of the patient. Once in place, the swab was rotated 3 times and then kept in place for 15 seconds to absorb nasal secretions. The same procedure was repeated with the right nostril using the same swab. Dry AN swabs were stored at 4° C. and tested using STOPCovid.v2 within 24 hours as described above for negative AN swabs. Fluorescence threshold for classifying samples as positive or negative was set to approximately 10% of the average steady state fluorescence signal, or 500 RFU on the Biorad CFX96 qPCR machine.

Lateral Flow Band Quantification

Acquired images were converted to 8-bit grayscale using photoshop and then imported into ImageLab software (BioRad Image Lab Software 6.0.1). Images were inverted and lanes were manually adjusted to fit the lateral flow strips. Bands were picked automatically and the background was adjusted manually to allow band comparison. Width of bands and background adjustment was kept constant between all bands in the same image. The band intensity ratio is calculated as the intensity of the top (test) band divided by the bottom (control) band.

Mobile Phone Application

For classifying STOPCovid lateral flow strip results, the mobile application used >50 images containing >500 lateral flow strips that have been manually annotated as positive or negative to set the appropriate threshold for the band intensity ratio. As the lateral flow strip typically has a faint background for the top (test) band, this threshold was determined to be 0.14. To use the STOPCovid mobile phone application for interpreting lateral flow trip results, download the Expo application for iOS (apple.co/2c6HMtp) or Android (bit.ly/2bZq5ew). Launch the Expo application, tap “Sign in to your account”, and sign in with the STOPCovid team's Expo credentials. Please contact the STOPCovid team through the STOPCovid website (stopcovid.science/) for credentials. Open STOPCovid from the Expo application.

STOPCovid.v2 Reagents and Protocol

Sequences LAMP Primers (IDT): F3: (SEQ ID NO: 62062) 5′-GCTGCTGAGGCTTCTAAG-3′ B3: (SEQ ID NO: 62063) 5′-GCGTCAATATGCTTATTCAGC-3′ FIP: (SEQ ID NO: 62064) 5′-GCGGCCAATGTTTGTAATCAGTAGACGTGGTCCAGAACAA-3′ BIP: (SEQ ID NO: 62065) 5′-TCAGCGTTCTTCGGAATGTCGCTGTGTAGGTCAACCACG-3′ LoopF: (SEQ ID NO: 62066) 5′-CCTTGTCTGATTAGTTCCTGGT-3′ (SEQ ID NO: 62067) LoopB: 5′-TGGCATGGAAGTCACACC-3′ AapCas12b Guide RNA (Synthego): (SEQ ID NO: 62068) 5′-GUCUAGAGGACAGAAUUUUUCAACGGGUGUGCCAAU GGCCACUUUCCAGGUGGCAAAGCCCGUUGAGCUUCUCAA AUCUGAGAAGUGGCAC CGAAGAACGCUGAAGCGCUG -3′ (The spacer targeting N gene is underlined.) AapCas12b Protein Sequence: (SEQ ID NO: 62069) MAVKSMKVKLRLDNMPEIRAGLWKLHTEVNAGVRYY TEWLSLLRQENLYRRSPNGDGEQECYKTAEECKAE LLERLRARQVENGHCGPAGSDDELLQLARQLYELL VPQAIGAKGDAQQIARKFLSPLADKDAVGGLGIAK AGNKPRWVRMREAGEPGWEEEKAKAEARKSTDRTA DVLRALADFGLKPLMRVYTDSDMSSVQWKPLRKGQ AVRTWDRDMFQQAIERMMSWESWNQRVGEAYAKLV EQKSRFEQKNFVGQEHLVQLVNQLQQDMKEASHGL ESKEQTAHYLTGRALRGSDKVFEKWEKLDPDAPFD LYDTEIKNVQRRNTRRFGSHDLFAKLAEPKYQALW REDASFLTRYAVYNSIVRKLNHAKMFATFTLPDAT AHPIWTRFDKLGGNLHQYTFLFNEFGEGRHAIRFQ KLLTVEDGVAKEVDDVTVPISMSAQLDDLLPRDPH ELVALYFQDYGAEQHLAGEFGGAKIQYRRDQLNHL HARRGARDVYLNLSVRVQSQSEARGERRPPYAAVF RLVGDNHRAFVHFDKLSDYLAEHPDDGKLGSEGLL SGLRVMSVDLGLRTSASISVFRVARKDELKPNSEG RVPFCFPIEGNENLVAVHERSQLLKLPGETESKDL RAIREERQRTLRQLRTQLAYLRLLVRCGSEDVGRR ERSWAKLIEQPMDANQMTPDWREAFEDELQKLKSL YGICGDREWTEAVYESVRRVWRHMGKQVRDWRKDV RSGERPKIRGYQKDVVGGNSIEQIEYLERQYKFLK SWSFFGKVSGQVIRAEKGSRFAITLREHIDHAKED RLKKLADRIIMEALGYVYALDDERGKGKWVAKYPP CQLILLEELSEYQFNNDRPPSENNQLMQWSHRGVF QELLNQAQVHDLLVGTMYAAFSSRFDARTGAPGIR CRRVPARCAREQNPEPFPWWLNKFVAEHKLDGCPL RADDLIPTGEGEFFVSPFSAEEGDFHQIHADLNAA QNLQRRLWSDFDISQIRLRCDWGEVDGEPVLIPRT TGKRTADSYGNKVFYTKTGVTYYERERGKKRRKVF AQEELSEEEAELLVEADEAREKSVVLMRDPSGIIN RGDWTRQKEFWSMVNQRIEGYLVKQIRSRVRLQES ACENTGDI* Reporter DNA (IDT): Fluorescence: 5′-/5HEX/TTTTT/3IABkFQ/-3′ Lateral flow: 5′-/56-FAM/TTTTTTT/3Bio/-3′

Patient Samples

Patient nasopharyngeal (NP) and anterior nasal (AN) swab samples should be collected and processed according to the appropriate biosafety procedure. The 2020 CDC COVID-19 test protocol was utilized for specimen collection, which is available at cdc.gov/coronavirus/2019-nCoV/lab/guidelines-clinical-specimens. Swabs that do not soak up excessive volumes (>80 μL) of extraction buffer, such as flocked swabs, should be used. Reagents

Extraction Buffer:

Sera-Mag SpeedBeads Carboxyl Magnetic Beads (VWR 65152105050250)

-   -   Poly(ethylene glycol) 8,000 (Millipore Sigma 89510)     -   3 M Potassium chloride solution (Millipore Sigma 60135)     -   1 M Tris-HCl, pH 8.0 (Thermo Fisher Scientific AM9855G)     -   UltraPure 0.5 M EDTA, pH 8.0 (Thermo Fisher Scientific 15575020)     -   UltraPure DNAse/RNAse-Free Distilled Water (Thermo Fisher         Scientific 10977015)     -   10× concentrated QuickExtract Plant DNA Extraction Solution         (Lucigen, custom order). Once thawed, aliquot and store at         −20° C. to avoid >3 freeze-thaw cycles.

STOPCovid.v2 Reaction:

-   -   1 M Tris-HCl, pH 8.0 (Thermo Fisher Scientific AM9855G)     -   2 M Ammonium sulfate solution (Millipore Sigma 76399)     -   1 M Magnesium sulfate solution (Millipore Sigma M3409)     -   Tween 20 (Millipore Sigma P9416)     -   Bst 2.0 WarmStart DNA Polymerase (New England BioLabs M0538L)     -   WarmStart RTx Reverse Transcriptase (New England BioLabs M0380L)     -   100 mM Magnesium sulfate, supplied with M0538L and M0380L     -   AapCas12b protein (New England BioLabs, custom order) or         purified as described previously¹     -   10 mM Deoxynucleotide (dNTP) Solution Mix (New England BioLabs         N0447L)     -   Taurine (Millipore Sigma 86329)     -   Proteinase K Inhibitor (Millipore Sigma 539470)     -   Dimethyl sulfoxide (Millipore Sigma D2650)     -   UltraPure DNAse/RNAse-Free Distilled Water (Thermo Fisher         Scientific 10977015)     -   (Optional) AccuPlex SARS-CoV-2 Reference Material Kit v2         (SeraCare 0505-0133)     -   (Optional) HybriDetect Dipstick (Milenia Biotec GmbH MGHD 1)

Equipment

-   -   60° C. heat block, water bath, or sous-vide immersion cooker     -   Magnetic separator     -   (Optional) qPCR machine for fluorescence readout

Reagent Setup

Laboratory-developed magnetic beads:

1. Vortex the Sera-Mag SpeedBeads Carboxyl Magnetic Beads for 1 min. Add 10 mL to a 50 mL conical tube.

2. Using a 50 mL magnetic separator, pellet the magnetic beads.

3. Aspirate the supernatant and discard.

4. Wash beads twice with 10 mL of ddH₂O, resuspending the pellet each time by vortexing for 30 s.

5. Pellet the beads for the last time.

6. Prepare the bead buffer by mixing the following in a 500 mL reagent bottle.

TABLE 13A Component Amount 3M KCl 167 mL 1M Tris-HCl  5 mL 0.5M EDTA  1 mL PEG-8000  90 g

7. Fill with ddH₂O to 500 mL and invert 10 times to mix.

8. Filter through a vacuum filtration unit according to the manufacturer's instructions.

9. Remove the final wash fluid on the beads and add 10 mL of bead buffer.

10. Vortex for 30 s to resuspend the beads and transfer to the 500 mL bottle containing the bead buffer.

11. Invert to homogenize the beads with the buffer.

12. Beads can be aliquoted and stored at 4° C. for 1 month or −20° C. for up to 1 year.

Extraction Buffer:

1. Prepare the extraction buffer by mixing the following in a 50 mL conical tube.

TABLE 13B Component Amount (mL) Magnetic beads 26 10x QuickExtract Plant 4 ddH₂O 10 Total 40

2. Aliquot for storage at −20° C. for up to 1 year. Avoid more than 1 additional freeze-thaw cycle.

10×LAMP Primer Pool:

1. Resuspend LAMP primers with ddH₂O to 100 μM.

2. Prepare the 10×LAMP primer pool by mixing the following in a 1.5 mL tube.

TABLE 13C Component Amount (μL) F3 primer 20 B3 primer 20 FIP primer 160 BIP primer 160 LoopF primer 40 LoopB primer 40 ddH₂O 560 Total 1000

3. Aliquot for storage at −20° C. for up to 1 year.

10×STOPCovid.v2 reaction buffer:

1. Prepare the 10×STOPCovid.v2 reaction buffer by mixing the following in a 15 mL conical tube.

TABLE 13D Initial Final Amount Component concentration concentration (mL) Tris-HCl 1M  0.2M 2 (NH₄)₂SO₄ 2M  0.1M 0.5 Mg₂SO₄ 1M 0.02M 0.2 Tween 20 100% 0.1% 0.01 ddH₂O 7.29 Total 10

2. Adjust the pH of the solution to 8.8. The pH should be very close to 8.8 before adjusting. 3. Aliquot for storage at −20° C. for up to 1 year.

500 mM Taurine:

1. Resuspend 6.258 g of Taurine in 100 mL of ddH₂O. Heating at 37° C. may be required for resuspension.

2. Aliquot for storage at room temperature for up to 1 year. 10× Proteinase K Inhibitor:

1. Resuspend 10 mg of Proteinase K Inhibitor with 150 μL of DMSO to make the stock solution.

2. Dilute stock solution 1:100 with ddH₂O to make working aliquots. Store both stock and working solutions at −20° C. for up to 1 year.

STOPCovid.v2 Reaction:

1. Prepare the STOPCovid.v2 reaction by mixing the following for one reaction. Scale up volume as needed for additional reactions.

TABLE 13E Initial Final Amount Component concentration concentration (μL) STOPCovid.v2 10x 1x 5 reaction buffer dNTPs 10 mM 1.4 mM 7 Mg₂SO₄ 100 mM 8 mM 4 Bst 2.0 DNA Polymerase 8,000 units/mL 320 units/mL 2 RTx Reverse Transcriptase 15,000 units/mL 300 units/ml 1 LAMP primer pool 10x 1x 5 AapCas12b protein 2 mg/mL or 31.25 nM 0.102 15.4 μM AapCas12b sgRNA 100 μM 31.25 nM 0.156 Reporter DNA 100 μM 250 nM 0.125 (fluorescence)* Taurine 500 mM 50 mM 5 Proteinase K Inhibitor 10x 1x 5 ddH₂O 15.617 Total 50 *If performing lateral flow readout, use the lateral flow reporter instead of thefluorescence reporter, at a final concentration of 125-500 nM titrated for best signal-to-noise on each lot of Milenia HybriDetect Dipstick.

2. Aliquot and store at −20° C. for up to 1 year.

Protocol

1. Thaw extraction buffer and STOPCovid.v2 reaction at room temperature. Keep STOPCovid.v2 reaction on ice after thawing. Allow extraction buffer to equilibrate to room temperature before proceeding.

2. Vortex extraction buffer for 15s.

3. Dip dry NP or AN swab in 400 μL of extraction buffer in a 1.5 mL tube. Swirl swab against the side of the tube to dislodge material.

4. Vortex or pipette to mix. Incubate at room temperature for 10 mins.

5. Place sample and extraction buffer mix on magnet. Wait 5 mins or until solution is clear.

6. Aspirate the supernatant. Make sure to remove all of the supernatant.

7. Add 50 μL of STOPCovid reaction. Remove tube from magnet and spin down beads using a microcentrifuge.

8. Vortex or pipette to mix.

9. Pellet the beads at 5,000×g for 1 min. Lower speeds or a plate spinner may work as well.

10. Depending on the readout method: Fluorescence readout:

-   -   a. Run the reaction at 60° C. for 45 mins     -   b. Read out the fluorescence using the VIC/HEX channel on a qPCR         machine.

Lateral flow readout:

-   -   a. Run the reaction at 60° C. for 80 mins.     -   b. To prevent sample contamination, transfer sample to a         different work area. Place a HybriDetect Dipstick into each         reaction and wait for the reaction to flow through the dipstick.         Generally, 2 mins is enough time to develop a positive band at         the limit of detection.

TABLE 14 Name Sequence CDC N1 F GACCCCAAAATCAGCGAAAT (SEQ ID NO: 62070) CDC N1 R TCTGGTTACTGCCAGTTGAATCTG (SEQ ID NO: 62071) CDC N1 FAM-ACCCCGCATTACGTTTGGTGGACC-BHQ1 Probe (SEQ ID NO: 62072) CDC N2 F TTACAAACATTGGCCGCAAA (SEQ ID NO: 62073) CDC N2 R GCGCGACATTCCGAAGAA (SEQ ID NO: 62074) CDC N2 FAM-ACAATTTGCCCCCAGCGCTTCAG-BHQ1 Probe (SEQ ID NO: 62075) RFP F ACTTGATGTTGACGTTGTAGG (SEQ ID NO: 62076) RFP R AGTTCATCTACAAGGTGAAGCT (SEQ ID NO: 62077) RFP Probe FAM-CCCCGTAATGCAGAAGAAGA-BHQ1 (SEQ ID NO: 62078)

TABLE 15 Name Sequence ORF1ab Set 1 CGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTG target RNA GGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGA GATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTG ACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTG TCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAA TGCCCGTAATGGTGTTCTTATTAC (SEQ ID NO: 62079) ORF1ab Set 2 AATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGT target RNA CTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATG CGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTG CACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTA AGAGTGATGGAACTGGTACTATCTATACA (SEQ ID NO: 62080) S Set 1 target AGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACT RNA; S Set 2 TTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATA target RNA TGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCA CAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATG AAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCA CTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATT TGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACA GAATGTTCTCTATGAGAACC (SEQ ID NO: 62081) N Set 1 target CCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGA RNA; Zhang et TGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGG al target RNA TGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTA CTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAA CAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATA CACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTG CAATCGTGCTA (SEQ ID NO: 62082) N Set 2 target TAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACG RNA TACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACG TGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAA TCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAAT TTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCAT GGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCAT CAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTT GCTGAATAAGCATATTGACGCATACAAAACA (SEQ ID NO: 62083) Broughten et al TGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAA target RNA AGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAAC AAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGA ACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGC GCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACA CCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGAT GACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAG CATATTGACGCATACAAAACA (SEQ ID NO: 62084) ORF1ab Set 1 AACCAGTACCAGAGGTGAA (SEQ ID NO: 62085) F3 ORF1ab Set 1 CACCATTACGGGCATTTCTA (SEQ ID NO: 62086) B3 ORF1ab Set 1 TGTGCTGGAGCATCTCTTTTGTTTTGGGTGTGGACATTGC (SEQ ID FIP NO: 62087) ORF1ab Set 1 AGCCAAGAAACCAACTGAAACGCTACTTGACCATCAACTCTACC BIP (SEQ ID NO: 62088) ORF1ab Set 1 GTCCCAGATCACAGTATTAGCA (SEQ ID NO: 62089) LoopF ORF1ab Set 1 TGTGCACCACTCACTGTC (SEQ ID NO: 62090) LoopB ORF1ab Set 2 TAATGAGCTTAGTCCTGTTGC (SEQ ID NO: 62091) F3 ORF1ab Set 2 GTACCAGTTCCATCACTCTTAG (SEQ ID NO: 62092) B3 ORF1ab Set 2 AGCTAACGCATTGTCATCAGTGACGACAGATGTCTTGTGC (SEQ ID FIP NO: 62093) ORF1ab Set 2 AACACAACAAAGGGAGGTAGGTTCTAGCCCATTTCAAATCCTG BIP (SEQ ID NO: 62094) ORF1ab Set 2 CAAGCAGTTTGTGTAGTACCG (SEQ ID NO: 62095) LoopF ORF1ab Set 2 TTGTACTTGCACTGTTATCCGA (SEQ ID NO: 62096) LoopB S Set 1 F3 AAACCAAGCAAGAGGTCATT (SEQ ID NO: 62097) S Set 1 B3 GTATTTGTAATGCAGCACCTG (SEQ ID NO: 62098) S Set 1 FIP TGCACAAATGAGGTCTCTAGCACAGATGCTGGCTTCATCAA (SEQ ID NO: 62099) S Set 1 BIP TTGCCACCTTTGCTCACAGATTCCAACCAGAAGTGATTGTAC (SEQ ID NO: 62100) S Set 1 LoopF CAATATCACCAAGGCAATCACC (SEQ ID NO: 62101) S Set 1 LoopB TGATTGCTCAATACACTTCTGC (SEQ ID NO: 62102) S Set 2 F3 CAGATGCTGGCTTCATCAA (SEQ ID NO: 62103) S Set 2 B3 GAGAACATTCTGTGTAACTCCA (SEQ ID NO: 62104) S Set 2 FIP TGGCAAAACAGTAAGGCCGTTAATGGTGATTGCCTTGGTG (SEQ ID NO; 62105) S Set 2 BIP TTCTGCACTGTTAGCGGGTACGTATTTGTAATGCAGCACCTG (SEQ ID NO: 62106) S Set 2 LoopF AAATGAGGTCTCTAGCAGCAAT (SEQ ID NO: 62107) S Set 2 LoopB AATCACTTCTGGTTGGACCTT (SEQ ID NO: 62108) N Set 1 F3 CAAGGCGTTCCAATTAACAC (SEQ ID NO: 62109) N Set 1 B3 GCAGCATTGTTAGCAGGA (SEQ ID NO: 62110) N Set 1FIP ACCGTCACCACCACGAATTCCAATAGCAGTCCAGATGACC (SEQ ID NO: 62111) N Set 1 BIP CTAGGAACTGGGCCAGAAGCACCCATATGATGCCGTCT (SEQ ID NO: 62112) N Set 1 LoopF GCTCTTCGGTAGTAGCCAATT (SEQ ID NO: 62113) N Set 1 LoopB GACTTCCCTATGGTGCTAACAA (SEQ ID NO: 62114) N Set 2 F3 GCTGCTGAGGCTTCTAAG (SEQ ID NO: 62115) N Set 2 B3 GCGTCAATATGCTTATTCAGC (SEQ ID NO: 62116) N Set 2 FIP GCGGCCAATGTTTGTAATCAGTAGACGTGGTCCAGAACAA (SEQ ID NO: 62117) N Set 2 BIP TCAGCGTTCTTCGGAATGTCGCTGTGTAGGTCAACCACG (SEQ ID NO: 62118) N Set 2 LoopF CCTTGTCTGATTAGTTCCTGGT (SEQ ID NO: 62119) N Set 2 LoopB TGGCATGGAAGTCACACC (SEQ ID NO: 62120) ACTB Set 1 AAGATGAGATTGGCATGGC (SEQ ID NO: 62121) F3 ACTB Set 1 GCAAGGGACTTCCTGTAAC (SEQ ID NO: 62122) B3 ACTB Set 1 CTCCAACCGACTGCTGTCTTTGGCTTGACTCAGGATTT (SEQ ID FIP NO: 62123) ACTB Set 1 CCCAAAGTTCACAATGTGGCCGCATCTCATATTTGGAATGAC (SEQ BIP ID NO: 62124) ACTB Set 1 ACCTTCACCGTTCCAGTT (SEQ ID NO: 62125) LoopF ACTB Set 1 GGACTTTGATTGCACATTGTTG (SEQ ID NO: 62126) LoopB ACTB Set 2 ACTCTTCCAGCCTTCCTT (SEQ ID NO: 62127) F3 ACTB Set 2 GATCCACACGGAGTACTTG (SEQ ID NO: 62128) B3 ACTB Set 2 TGTGTTGGCGTACAGGTCAACTACCTTCAACTCCATCATG (SEQ ID FIP NO: 62129) ACTB Set 2 CACCATGTACCCTGGCATTGATCTTGATCTTCATTGTGCTG (SEQ BIP ID NO: 62130) ACTB Set 2 GGATGTCCACGTCACACT (SEQ ID NO: 62131) LoopF ACTB Set 2 GACAGGATGCAGAAGGAGA (SEQ ID NO: 62132) LoopB ACTB Set 3 GGCCGTCTTCCCCTCCAT (SEQ ID NO: 62133) F3 ACTB Set 3 CGCAGCTCATTGTAGAAGGT (SEQ ID NO: 62134) B3 ACTB Set 3 TTGCTCTGGGCCTCGTCGCAGGCACCAGGGCGTGA (SEQ ID NO: FIP 62135) ACTB Set 3 TGAAGTACCCCATCGAGCACGGGTGGTGCCAGATTTTCTCCA BIP (SEQ ID NO: 62136) ACTB Set 3 CCTTCTGACCCATGCCCACCA (SEQ ID NO: 62137) LoopF ACTB Set 3 CATCGTCACCAACTGGGACGAC (SEQ ID NO: 62138) LoopB ACTB Set 4 GCACCAGGGCGTGATG (SEQ ID NO: 62139) F3 ACTB Set 4 TCAGCAGCACGGGGTG (SEQ ID NO: 62140) B3 ACTB Set 4 GAGGATGCCTCTCTTGCTCTGGGTGGGCATGGGTCAGAAG (SEQ FIP ID NO: 62141) ACTB Set 4 AGTACCCCATCGAGCACGGCACGCAGCTCATTGTAGAAGGT (SEQ BIP ID NO: 62142) ACTB Set 4 CCTCGTCGCCCACATAGGAATC (SEQ ID NO: 62143) LoopF ACTB Set 4 TCGTCACCAACTGGGACGACA (SEQ ID NO: 62144) LoopB ACTB Set 5 TACGTTGCTATCCAGGCTGT (SEQ ID NO: 62145) F3 ACTB Set 5 AGTCAGGTCCCGGCCA (SEQ ID NO: 62146) B3 ACTB Set 5 TGACCCCGTCACCGGAGTCCGCTATCCCTGTACGCCTCT (SEQ ID FIP NO: 62147) ACTB Set 5 CCCACACTGTGCCCATCTACGCAGGTCCAGACGCAGGAT (SEQ ID BIP NO: 62148) ACTB Set 5 CGATGCCAGTGGTACGGCC (SEQ ID NO: 62149) LoopF ACTB Set 5 GGGGTATGCCCTCCCCCAT (SEQ ID NO: 62150) LoopB ACTB Set 6 GCTATCCCTGTACGCCTCT (SEQ ID NO: 62151) F3 ACTB Set 6 CGGTGAGGATCTTCATGAGG (SEQ ID NO: 62152) B3 ACTB Set 6 AGATGGGCACAGTGTGGGTGGGCCGTACCACTGGCA (SEQ ID NO: FIP 62153) ACTB Set 6 GGGGTATGCCCTCCCCCATTCAGTCAGGTCCCGGC (SEQ ID NO: BIP 62154) ACTB Set 6 CGTCACCGGAGTCCATCACGA (SEQ ID NO: 62155) LoopF ACTB Set 6 GCCATCCTGCGTCTGGACC (SEQ ID NO: 62156) LoopB ACTB Set 7 GGGAAATCGTGCGTGACA (SEQ ID NO: 62157) F3 ACTB Set 7 GGCTGGAAGAGTGCCTCA (SEQ ID NO: 62158) B3 ACTB Set 7 GGAAGCAGCCGTGGCCATCAAGGAGAAGCTGTGCTACGT (SEQ ID FIP NO: 62159) ACTB Set 7 TCCTCCCTGGAGAAGAGCTACGCCGCTCATTGCCAATGGT (SEQ ID BIP NO: 62160) ACTB Set 7 TTGCTCGAAGTCCAGGGCG (SEQ ID NO: 62161) LoopF ACTB Set 7 NULL LoopB ACTB Set 8 AAGGAGAAGCTGTGCTACGT (SEQ ID NO: 62162) F3 ACTB Set 8 TGCCCAGGAAGGAAGGC (SEQ ID NO: 62163) B3 ACTB Set 8 CGTAGCTCTTCTCCAGGGAGGAGCCCTGGACTTCGAGCA (SEQ ID FIP NO: 62164) ACTB Set 8 CCTGACGGCCAGGTCATCACCTGGAAGAGTGCCTCAGGG (SEQ ID BIP NO: 62165) ACTB Set 8 AGCAGCCGTGGCCATCTC (SEQ ID NO: 62166) LoopF ACTB Set 8 ATTGGCAATGAGCGGTTCCGC (SEQ ID NO: 62167) LoopB ACTB Set 9 GGCATCCACGAAACTACCTT (SEQ ID NO: 62168) F3 ACTB Set 9 ACTTGCGCTCAGGAGGAG (SEQ ID NO: 62169) B3 ACTB Set 9 CCGCCAGACAGCACTGTGTTTCATGAAGTGTGACGTGGAC (SEQ FIP ID NO: 62170) ACTB Set 9 CACCACCATGTACCCTGGCATTTCATTGTGCTGGGTGCC (SEQ ID BIP NO: 62171) ACTB Set 9 GGCGTACAGGTCTTTGCGGAT (SEQ ID NO: 62172) LoopF ACTB Set 9 TGCCGACAGGATGCAGAAGG (SEQ ID NO: 62173) LoopB ACTB Set 10 ATGCAGAAGGAGATCACTGC (SEQ ID NO: 62174) F3 ACTB Set 10 TTTGCGGTGGACGATGGA (SEQ ID NO: 62175) B3 ACTB Set 10 CACACGGAGTACTTGCGCTCACTGGCACCCAGCACAATG (SEQ ID FIP NO: 62176) ACTB Set 10 CTCCATCCTGGCCTCGCTGTCGTCATACTCCTGCTTGCTG (SEQ ID BIP NO: 62177) ACTB Set 10 NULL LoopF ACTB Set 10 CCACCTTCCAGCAGATGTGGAT (SEQ ID NO: 62178) LoopB GAPDH Set 1 AAAGGGTCATCATCTCTGC (SEQ ID NO: 62179) F3 GAPDH Set 1 ATGATGTTCTGGAGAGCC (SEQ ID NO: 62180) B3 GAPDH Set 1 GCTAAGCAGTTGGTGGTGGAACCATGAGAAGTATGACAAC (SEQ FIP ID NO: 62181) GAPDH Set 1 GGTATCGTGGAAGGACTCATCCATCCACAGTCTTCTGG (SEQ ID BIP NO: 62182) GAPDH Set 1 TTGCTGATGATCTTGAGGC (SEQ ID NO: 62183) LoopF GAPDH Set 1 CAGTCCATGCCATCACTG (SEQ ID NO: 62184) LoopB GAPDH Set 2 ATGAGAAGTATGACAACAGCC (SEQ ID NO: 62185) F3 GAPDH Set 2 GATGATGTTCTGGAGAGCC (SEQ ID NO: 62186) B3 GAPDH Set 2 TGTCATGGATGACCTTGGCAGATCATCAGCAATGCCTC (SEQ ID FIP NO: 62187) GAPDH Set 2 GGTATCGTGGAAGGACTCATGGCCATCCACAGTCTTCTG (SEQ ID BIP NO: 62188) GAPDH Set 2 GCTAAGCAGTTGGTGGTG (SEQ ID NO: 62189) LoopF GAPDH Set 2 ACAGTCCATGCCATCACT (SEQ ID NO: 62190) LoopB GAPDH Set 3 GTGAAGGTCGGAGTCAAC (SEQ ID NO: 62191) F3 GAPDH Set 3 CTCCATGGTGGTGAAGAC (SEQ ID NO: 62192) B3 GAPDH Set 3 GGGTGGAATCATATTGGAACATAGTGGATATTGTTGCCATCA FIP (SEQ ID NO: 62193) GAPDH Set 3 CACCGTCAAGGCTGAGAAATCTCGCTCCTGGAAGAT (SEQ ID NO: BIP 62194 GAPDH Set 3 ACCATGTAGTTGAGGTCAATG (SEQ ID NO: 62195) LoopF GAPDH Set 3 GGAAGCTTGTCATCAATGGA (SEQ ID NO: 62196) LoopB GAPDH Set 4 ACCATGAGAAGTATGACAACAG (SEQ ID NO: 62197) F3 GAPDH Set 4 GATGATGTTCTGGAGAGCC (SEQ ID NO: 62198) B3 GAPDH Set 4 TGTCATGGATGACCTTGGCCTCAAGATCATCAGCAATGC (SEQ ID FIP NO: 62199) GAPDH Set 4 GGTATCGTGGAAGGACTCATGGCCATCCACAGTCTTCTG (SEQ ID BIP NO: 62200) GAPDH Set 4 GCTAAGCAGTTGGTGGTG (SEQ ID NO: 62201) LoopF GAPDH Set 4 ACAGTCCATGCCATCACT (SEQ ID NO: 62202) LoopB GAPDH Set 5 GTGAAGGTCGGAGTCAAC (SEQ ID NO: 62203) F3 GAPDH Set 5 GACTCCACGACGTACTCA (SEQ ID NO: 62204) B3 GAPDH Set 5 TGGGTGGAATCATATTGGAACAGGATATTGTTGCCATCAATGAC FIP (SEQ ID NO: 62205) GAPDH Set 5 ACCGTCAAGGCTGAGAACGATCTCGCTCCTGGAAGA (SEQ ID NO: BIP 62206) GAPDH Set 5 AACCATGTAGTTGAGGTCAATG (SEQ ID NO: 62207) LoopF GAPDH Set 5 GGAAGCTTGTCATCAATGGAA (SEQ ID NO: 62208) LoopB GAPDH Set 6 TGGTATCGTGGAAGGACTCA (SEQ ID NO: 62209) F3 GAPDH Set 6 CGTTCAGCTCAGGGATGAC (SEQ ID NO: 62210) B3 GAPDH Set 6 ACGCCACAGTTTCCCGGAGGTGACCACAGTCCATGCCA (SEQ ID FIP NO: 62211) GAPDH Set 6 CGCGGGGCTCTCCAGAACACTTGCCCACAGCCTTGG (SEQ ID NO: BIP 62212) GAPDH Set 6 ACAGTCTTCTGGGTGGCAGTGA (SEQ ID NO: 62213) LoopF GAPDH Set 6 CATCCCTGCCTCTACTGGCGC (SEQ ID NO: 62214) LoopB GAPDH Set 7 TCGTGGAAGGACTCATGACC SEQ ID NO: 62215) F3 GAPDH Set 7 CGTTCAGCTCAGGGATGAC (SEQ ID NO: 62216) B3 GAPDH Set 7 ACGCCACAGTTTCCCGGAGGACAGTCCATGCCATCACTGC (SEQ FIP ID NO: 62217) GAPDH Set 7 CGCGGGGCTCTCCAGAACACTTGCCCACAGCCTTGG (SEQ ID NO: BIP 62218) GAPDH Set 7 GCCATCCACAGTCTTCTGGGTG (SEQ ID NO: 62219) LoopF GAPDH Set 7 CATCCCTGCCTCTACTGGCGC (SEQ ID NO: 62220) LoopB GAPDH Set 8 GACCACAGTCCATGCCATC (SEQ ID NO: 62221) F3 GAPDH Set 8 GGCCATGCCAGTGAGCT (SEQ ID NO: 62222) B3 GAPDH Set 8 TGTTCTGGAGAGCCCCGCGACTGCCACCCAGAAGACT (SEQ ID FIP NO: 62223) GAPDH Set 8 CATCCCTGCCTCTACTGGCGCTCCCGTTCAGCTCAGGGAT (SEQ ID BIP NO: 62224) GAPDH Set 8 ACGCCACAGTTTCCCGGAGG (SEQ ID NO: 62225) LoopF GAPDH Set 8 TGCCAAGGCTGTGGGCAA (SEQ ID NO: 62226) LoopB GAPDH Set 9 GCGCTGCCAAGGCTGT (SEQ ID NO: 62227) F3 GAPDH Set 9 CCCAGGATGCCCTTGAGG (SEQ ID NO: 62228) B3 GAPDH Set 9 GTGGGGACACGGAAGGCCAGGGCAAGGTCATCCCTGA (SEQ ID FIP NO: 62229) GAPDH Set 9 TGCCAACGTGTCAGTGGTGGACTGCTTCACCACCTTCTTGA (SEQ BIP ID NO: 62230) GAPDH Set 9 CCAGTGAGCTTCCCGTTCAGC (SEQ ID NO: 62231) LoopF GAPDH Set 9 TGCCGTCTAGAAAAACCTGCCA (SEQ ID NO: 62232) LoopB

TABLE 16 Name sgRNA Sequence ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTAGTCCCAGATCACAGTATT Guide 1 (SEQ ID NO: 62233) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTAGTCCCAGATCACAGTAT Guide 2 (SEQ ID NO: 62234) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTGTAGTCCCAGATCACAGTA Guide 3 (SEQ ID NO: 62235) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCTGCTAATACTGTGATCTGG Guide 4 (SEQ ID NO: 62236) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGCTATGTCAGTCATAGAACA Guide 5 (SEQ ID NO: 62237) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTTGGCTATGTCAGTCATAGA Guide 6 (SEQ ID NO: 62238) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCTTGGCTATGTCAGTCATAG Guide 7 (SEQ ID NO: 62239) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTTTCTTGGCTATGTCAGTC Guide 8 (SEQ ID NO: 62240) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTGTTTGTTCTATGACTGAC Guide 9 (SEQ ID NO: 62241) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACAGTTGGTTTCTTGGCTATGT Guide 10 (SEQ ID NO: 62242) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCAGTTGGTTTCTTGGCTATG Guide 11 (SEQ ID NO: 62243) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTTCTATGACTGACATAGCC Guide 12 (SEQ ID NO: 62244) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTTCTATGACTGACATAGCCA Guide 13 (SEQ ID NO: 62245) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTATGACTGACATAGCCAAGA Guide 14 (SEQ ID NO: 62246) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTGCACCACTCACTGTCTTT Guide 15 (SEQ ID NO: 62247) ORF1ab GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Set 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTGCACCACTCACTGTCTTTT Guide 16 (SEQ ID NO: 62248) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTGCACAAATGAGGTCTCTAG (SEQ ID NO: 62249) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 2 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCCTTGGTGATATTGCTGCTA (SEQ ID NO: 62250) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 3 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTGCACAAATGAGGTCTCTA (SEQ ID NO: 62251) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 4 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTGTGCACAAATGAGGTCTCT (SEQ ID NO: 62252) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 5 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACAACTTTTGTGCACAAATGAG (SEQ ID NO: 62253) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 6 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTGCACAAAAGTTTAACGGC (SEQ ID NO: 62254) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 7 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTGCACAAAAGTTTAACGGCC (SEQ ID NO: 62255) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 8 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACAACGGCCTTACTGTTTTGCC (SEQ ID NO: 62256) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 9 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACACGGCCTTACTG TTTTGCCA (SEQ ID NO: 62257) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 10 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCTG TTTTGCCACCTTTGCTC (SEQ ID NO: 62258) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 11 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTGCCACCTTTGCTCACAGAT (SEQ ID NO: 62259) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 12 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGCCACCTTTGCTCACAGATG (SEQ ID NO: 62260) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 13 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCCACCTTTGCTCACAGATGA (SEQ ID NO: 62261) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 14 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGCTCACAGATGAAATGATTG (SEQ ID NO: 62262) S Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 15 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCTCACAGATGAAATGATTGC (SEQ ID NO: 62263) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTCTGGTAGCTCTTCGGTAG (SEQ ID NO: 62264) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 2 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCCGTCACCACCACGAATTCG (SEQ ID NO: 62265) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 3 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACACCGTCACCACCACGAATTC (SEQ ID NO: 62266) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 4 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTACCGTCACCACCACGAATT (SEQ ID NO: 62267) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 5 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACATTTTACCGTCACCACCACG (SEQ ID NO: 62268) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 6 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCATTTTACCGTCACCACCAC (SEQ ID NO: 62269) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 7 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGACTGAGATCTTTCATTT IA (SEQ ID NO: 62270) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 8 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTGGTGGTGACGGTAAAATG (SEQ ID NO: 62271) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 9 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCTAGGTAGTAGAAATACCAT (SEQ ID NO: 62272) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 10 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTGGCCCAGTTCCTAGGTAGT (SEQ ID NO: 62273) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 11 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCTACTACCTAGGAACTGGGC (SEQ ID NO: 62274) N Set 1 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 12 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTACTACCTAGGAACTGGGCC (SEQ ID NO: 62275) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 1 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCTGGTCCCCAAAATTTCCTT (SEQ ID NO: 62276) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 2 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTTCCTGGTCCCCAAAATTT (SEQ ID NO: 62277) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 3 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTCTGATTAGTTCCTGGTCCC (SEQ ID NO: 62278) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 4 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCTTGTCTGATTAGTTCCTGG (SEQ ID NO: 62279) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 5 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTAATCAGTTCCTTGTCTGAT (SEQ ID NO: 62280) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 6 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGTAATCAGTTCCTTGTCTGA (SEQ ID NO: 62281) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 7 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCGGCCAATGTTTGTAATCAG (SEQ ID NO: 62282) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 8 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGCGGCCAATGTTTGTAATCA (SEQ ID NO: 62283) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 9 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTGCAATTTGCGGCCAATGTT (SEQ ID NO: 62284) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 10 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGCCGCAAATTGCACAATTTG (SEQ ID NO: 62285) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 11 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCGAAGAACGCTGAAGCGCTG (SEQ ID NO: 62286) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 12 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCACAATTTGCCCCCAGCGCT (SEQ ID NO: 62287) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 13 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGCCCCCAGCGCTTCAGCGTT (SEQ ID NO: 62288) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 14 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACCCCCCAGCGCTTCAGCGTTC (SEQ ID NO: 62289) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 15 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACAGCGTTCTTCGGAATGTCGC (SEQ ID NO: 62290) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 16 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACTTCGGAATGTCGCGCATTGG (SEQ ID NO: 62291) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 17 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGGAATGTCGCGCATTGGCAT (SEQ ID NO: 62292) N Set 2 GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCAA Guide 18 AGCCCGTTGAGCTTCTCAAATCTGAGAAGTGGCACGCATGGAAGTCACACCTTCG (SEQ ID NO: 62292)

Various modifications and variations of the described methods, pharmaceutical compositions, and kits of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific embodiments, it will be understood that it is capable of further modifications and that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention that are obvious to those skilled in the art are intended to be within the scope of the invention. This application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure come within known customary practice within the art to which the invention pertains and may be applied to the essential features hereinbefore set forth. 

1. A composition for detecting the presence of a target polynucleotide in a sample, comprising isothermal amplification reagents for amplifying the target polynucleotide, and an extraction-free solution for isolating polynucleotides from a cell or virus particle.
 2. The composition of claim 1, wherein the isothermal amplification reagents are LAMP reagents comprising F3, B3, FIP, BIP, Loop Forward and Loop Reverse primers.
 3. The composition of claim 2, further comprising oligonucleotide strand displacement (OSD) probes.
 4. The compositions of claim 3, wherein the OSD probes are selected from Table
 11. 5. The composition of claim 4 wherein the OSD probes are provided at a concentration of 50 nM to 175 nM, preferably 75 nM to 150 nM.
 6. The composition of claim 1, wherein the target polynucleotide is a viral polynucleotide or bacterial polynucleotide.
 7. The composition of claim 6, wherein the viral polynucleotide is an influenza, adenovirus, respiratory syncytial virus, papillomavirus, herpesvirus, human immunodeficiency virus, hepatits, rhinovirus.
 8. The composition of claim 7, wherein the LAMP primers are selected from SEQ ID NOs: 1-40,499 and 61,983-61,988, or Table
 15. 9. The composition of claim 6, wherein the viral polynucleotide is a coronavirus polynucleotide.
 10. The composition of claim 9, wherein the coronavirus polynucleotide is SARS-Cov-2.
 11. The composition of claim 10, wherein the F3 primer is selected from Table 5 or Table
 10. 12. The composition of claim 1, wherein the bacterial polynucleotide is Neisseria gonnorrhoea or Streptococcus pyogenes.
 13. The composition of claim 1, further comprising one or more additives, wherein the additive is L-proline, L-histidine, b-alanine, L-serine, urea, acetamide, 4-aminobutyric acid, polyethylene glycol, polypropylene glycol, polyvinylpyrrolidone K, 6-O-a-D-maltosyl-b-cyclodextrin, (2-hydroxypropyl)-b-cyclodextrin, a-cyclodextrin, b-cyclodextrin, methyl-b-cyclodextrin, glycine, proline, taurine, or a combination thereof.
 14. The composition of claim 13, wherein the additive is glycine, taurine, and/or proline.
 15. The composition of claim 13, further comprising polynucleotide bind beads for the capture of nucleic acids in a sample.
 16. A method of detecting a target nucleic acid in a sample comprising: distributing a sample or set of samples into one or more individual discrete volumes each individual discrete volume comprising a composition according to claim 1; incubating the sample or set of samples at conditions sufficient to allow extraction of target polynucleotides from the sample, incubating the sample at an isothermal temperature to generate amplicons of target polynucleotides, wherein isolation of polynucleotides is not required between the extraction or amplification step; and detecting the one or more amplicons, thereby indicated the presence of one or more target polynucleotides in the sample.
 17. The method of claim 16, wherein the amplification reagents comprise LAMP primers and the isothermal incubation temperature is between 55° C. and 65° C.
 18. The method of claim 16, wherein detection of target polynucleotides occurs in one hour or less.
 19. A composition for detecting the presence of a target polynucleotide in a sample, comprising: an extraction-free polynucleotide isolation solution; one or more Cas proteins possessing collateral activity; at least one guide polynucleotide comprising a sequence capable of binding a target polynucleotide and designed to form a complex with the one or more Cas proteins; isothermal amplification reagents; and a detection construct comprising a polynucleotide component, wherein the Cas protein exhibits collateral nuclease activity and cleaves the polynucleotide component of the detection construct once activated by the target sequence;
 20. The composition of claim 19, wherein the one or more Cas proteins is a Type V Cas, a Type VI Cas, or a combination thereof.
 21. The composition of claim 19, wherein the one or more Cas proteins is thermostable exhibiting nuclease activity at temperature of at least 50° C.
 22. The composition of claim 19, wherein the Cas is a Cas12b.
 23. The composition of claim 22, wherein the Cas12b is selected from Table 2A or Table 2B.
 24. (canceled)
 25. (canceled)
 26. (canceled)
 27. (canceled)
 28. The composition of claim 19, wherein the guide polynucleotide is designed to bind to a target nucleic acid of a microbe.
 29. The composition of claim 28, wherein the microbe is selected from human papillomavirus, hepatitis, adenovirus, coronavirus, herpesvirus, human immunodeficiency virus, influenza virus, rhinovirus, Neisseria gonorrhoeae, Respiratory syncytial virus, coronavirus, or Streptococcus pyogenes.
 30. The composition of claim 19, wherein the isothermal amplification reagents are LAMP amplification reagents.
 31. (canceled)
 32. (canceled)
 33. The composition of claim 29, wherein the guide polynucleotide comprises a spacer specific for the N gene or S gene of SARS-CoV-2.
 34. The composition of claim 19, further comprising one or more additives to increase reaction specificity or kinetics.
 35. The composition of claim 19, further comprising polynucleotide binding beads.
 36. A method for detecting coronavirus in a sample, the method comprising: distributing a sample or set of samples into individual discrete volumes, each individual discrete volume comprising a composition of claim 19; incubating the sample or set of samples at conditions sufficient to allow lysis of a cell or virus via reagents of the extraction-free solution; amplifying the target polynucleotides using isothermal amplification, wherein isolation of target polynucleotides between the incubating and amplifying steps is not required; and detecting amplified target polynucleotides by binding of the CRISPR-Cas complex to the target polynucleotides, wherein binding of the target polynucleotides activates cleavage of the detection construct thereby generating a detectable signal.
 37. The method of claim 36, wherein the extraction-free solution is mixed with a sample at a concentration of about 1:2 to 2:1 sample:extraction solution.
 38. The method of claim 36, wherein the incubating step is performed at a temperature of about 20° C. to 60° C. for about 60 minutes, or 95° C. for about 5 to 10 minutes.
 39. The method of claim 36, wherein the amplifying and detecting steps are performed at about 55° C. to about 65° C., about 59° C. to 61° C. or about 60° C. for 50 to 70 minutes.
 40. The method of claim 39, wherein the target polynucleotide is detected in one hour or less.
 41. The method of claim 36, wherein the steps of extracting, amplifying incubating, activating and detecting are all performed in the same individual discrete volume. 42.-59. (canceled) 